Yamazaki Yu 山崎雄

Researcher Number	70866243
Other IDs
Affiliation (Current)	2025: 広島大学, 医系科学研究科(医), 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 広島大学, 医系科学研究科(医), 特定准教授 2022: 広島大学, 医系科学研究科(医), 講師 2021: 広島大学, 病院(医), 講師 2020: 広島大学, 病院(医), 助教
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Basic Section 52010:General internal medicine-related
Keywords	Principal Investigator APOE / アルツハイマー病 / 認知症 / アミロイドβ

APOE2がもつ神経保護作用を利用したアルツハイマー病の病態制御Principal Investigator
- Principal Investigator
  
  山崎雄
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Hiroshima University
肝臓-脳連関に着目した新たな認知症先制治療戦略の探索Principal Investigator
- Principal Investigator
  
  山崎雄
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Hiroshima University
Harnessing brain cortex-derived molecular data to unravel the mechanism underlying the APOE4-associated development of dementiaPrincipal Investigator
- Principal Investigator
  
  Yamazaki Yu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Hiroshima University

All 2023 2022

All Journal Article Presentation

[Journal Article] LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE42023
- Author(s)
  Oue H, Yamazaki Y, Qiao W, Yuanxin C, Ren Y, Kurti A, Shue F, Parsons TM, Perkerson RB, Kawatani K, Wang N, Starling SC, Roy B, Mosneag IE, Aikawa T, Holm ML, Liu CC, Inoue Y, Sullivan PM, Asmann YW, Kim BY, Bu G, Kanekiyo T.
- Journal Title
  
  JCI Insight
  
  Volume: 8 Issue: 7
- DOI
  10.1172/jci.insight.163822
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19710
[Journal Article] Amyloid Beta Is Internalized via Macropinocytosis, an HSPG- and Lipid Raft-Dependent and Rac1-Mediated Process2022
- Author(s)
  Keyoumu Nazere, Tetsuya Takahashi, Naoyuki Hara, Kazuki Muguruma, Masahiro Nakamori, Yu Yamazaki, Hiroyuki, Morino Hirofumi, Maruyama
- Journal Title
  
  Frontiers in Molecular Neuroscience
  
  Volume: - Pages: 804702-804702
- DOI
  10.3389/fnmol.2022.804702
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07974, KAKENHI-PROJECT-21K17512, KAKENHI-PROJECT-20H03578
[Presentation] Transcriptome profiling in AD cases to identify distinct associations with AD-related neuropathology and protein levels in the brain2022
- Author(s)
  Mariet Allen, Zachary Quicksall, Xue Wang, Joseph S Reddy, Jeremiah Bergman, Stephanie R Oatman, Thuy Nguyen, Kimberly G Malphrus, Sarah J Lincoln, Yu Yamazaki, Yuka A Martens, Na Zhao, Michael DeTure, Melissa E Murray, Chia-Chen Liu, Takahisa Kanekiyo, Dennis W Dickson, Guojun Bu, Nilufer Ertekin-Taner
- Organizer
  Alzheimer's Association International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03578
[Presentation] Association of DNA methylation from the temporal cortex and cerebellum with AD-related neuropathology and biochemistry2022
- Author(s)
  Stephanie R Oatman, Mariet Allen, Zachary Quicksall, Joseph S Reddy, Minerva M Carrasquillo, Xue Wang, Chia-Chen Liu, Yu Yamazaki, Thuy Nguyen, Michael G Heckman, Yuka A Martens, Na Zhao, Michael DeTure, Melissa E Murray, Takahisa Kanekiyo, Dennis W Dickson, Guojun Bu, Nilufer Ertekin-Taner
- Organizer
  Alzheimer's Association International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03578

1. 高橋哲也 (00435942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 今野歩 (40509048)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Yamazaki Yu 山崎雄

Research Projects

Research Products

Co-Researchers

APOE2がもつ神経保護作用を利用したアルツハイマー病の病態制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

肝臓-脳連関に着目した新たな認知症先制治療戦略の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Harnessing brain cortex-derived molecular data to unravel the mechanism underlying the APOE4-associated development of dementiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE42023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Amyloid Beta Is Internalized via Macropinocytosis, an HSPG- and Lipid Raft-Dependent and Rac1-Mediated Process2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] Transcriptome profiling in AD cases to identify distinct associations with AD-related neuropathology and protein levels in the brain2022

Author(s)

Organizer

Data Source

[Presentation] Association of DNA methylation from the temporal cortex and cerebellum with AD-related neuropathology and biochemistry2022

Author(s)

Organizer

Data Source

Yamazaki Yu 山崎 雄

Research Projects

Research Products

Co-Researchers

APOE2がもつ神経保護作用を利用したアルツハイマー病の病態制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

肝臓-脳連関に着目した 新たな認知症先制治療戦略 の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Harnessing brain cortex-derived molecular data to unravel the mechanism underlying the APOE4-associated development of dementiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE42023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Amyloid Beta Is Internalized via Macropinocytosis, an HSPG- and Lipid Raft-Dependent and Rac1-Mediated Process2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] Transcriptome profiling in AD cases to identify distinct associations with AD-related neuropathology and protein levels in the brain2022

Author(s)

Organizer

Data Source

[Presentation] Association of DNA methylation from the temporal cortex and cerebellum with AD-related neuropathology and biochemistry2022

Author(s)

Organizer

Data Source

Yamazaki Yu 山崎雄

肝臓-脳連関に着目した新たな認知症先制治療戦略の探索Principal Investigator