Yoshinaga Masanori 吉永正憲

Researcher Number	70878347
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 助教
Affiliation (based on the past Project Information) *help	2020 – 2025: 京都大学, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (III) / Basic Section 59040:Nutrition science and health science-related / Basic Section 49010:Pathological biochemistry-related / 0802:Biomedical structure and function and related fields
Keywords	Principal Investigator 炎症制御 / RNA修飾 / 赤芽球分化 / 翻訳制御 / 造血制御 / コドンバイアス / 炎症応答 / マクロファージ / 代謝制御 / DNA損傷 / CRISPRスクリーニング / 鉄代謝

コドンバイアス認識を介した自己指向性免疫応答の解明Principal Investigator
- Principal Investigator
  
  吉永正憲
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kyoto University
アミノ酸代謝が司る代謝リプログラミング機構の解明Principal Investigator
- Principal Investigator
  
  吉永正憲
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kyoto University
RNAメチル化修飾破綻による自己指向性免疫応答の解明Principal Investigator
- Principal Investigator
  
  吉永正憲
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kyoto University
Regulation of erythroid differentiation by RNA methylationPrincipal Investigator
- Principal Investigator
  
  Yoshinaga Masanori
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Kyoto University
Posttranscriptional regulation of iron metabolism via RNA methylationPrincipal Investigator
- Principal Investigator
  
  Yoshinaga Masanori
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0802:Biomedical structure and function and related fields
- Research Institution
  Kyoto University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] RNA Metabolism Governs Immune Function and Response2024
- Author(s)
  Yoshinaga Masanori、Takeuchi Osamu
- Journal Title
  
  Advances in experimental medicine and biology
  
  Volume: 1444 Pages: 145-161
- DOI
  10.1007/978-981-99-9781-7_10
- ISBN
  9789819997800, 9789819997817
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15372, KAKENHI-PROJECT-23H00402
[Journal Article] Regulation of inflammatory diseases via the control of mRNA decay2024
- Author(s)
  Yoshinaga Masanori、Takeuchi Osamu
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 44 Issue: 1 Pages: 14-14
- DOI
  10.1186/s41232-024-00326-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15372, KAKENHI-PROJECT-23H00402
[Journal Article] RNA分解酵素Regnase-1を標的とした炎症制御法の開発2023
- Author(s)
  吉永正憲, 竹内理
- Journal Title
  
  医学のあゆみ
  
  Volume: 284 Pages: 152-3
- Data Source
  KAKENHI-PROJECT-21K15372
[Journal Article] RNA修飾が織りなす免疫制御メカニズム2023
- Author(s)
  吉永正憲
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 80 Pages: 434-440
- Data Source
  KAKENHI-PROJECT-21K15372
[Journal Article] The crossroads of RNA methylation and ferroptosis: Implications for disease pathogenesis2023
- Author(s)
  Yoshinaga Masanori
- Journal Title
  
  Clinical and Translational Discovery
  
  Volume: 3 Issue: 6
- DOI
  10.1002/ctd2.244
- Open Access
- Data Source
  KAKENHI-PROJECT-21K15372
[Journal Article] Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages2022
- Author(s)
  Yaku Ai、Inagaki Tadakatsu、Asano Ryotaro、Okazawa Makoto、Mori Hiroyoshi、Sato Ayuko、Hia Fabian、Masaki Takeshi、Manabe Yusuke、Ishibashi Tomohiko、Vandenbon Alexis、Nakatsuka Yoshinari、Akaki Kotaro、Yoshinaga Masanori、Uehata Takuya、Mino Takashi、Morita Satoshi、Ishibashi-Ueda Hatsue、Morinobu Akio et al.
- Journal Title
  
  Circulation
  
  Volume: 146 Issue: 13 Pages: 1006-1022
- DOI
  10.1161/circulationaha.122.059435
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15372, KAKENHI-PROJECT-22K16121, KAKENHI-PROJECT-18H05278
[Journal Article] Cyclin J-CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism2022
- Author(s)
  Chong Yee Kien、Tartey Sarang、Yoshikawa Yuki、Imami Koshi、Li Songling、Yoshinaga Masanori、Hirabayashi Ai、Liu Guohao、Vandenbon Alexis、Hia Fabian、Uehata Takuya、Mino Takashi、Suzuki Yutaka、Noda Takeshi、Ferrandon Dominique、Standley Daron M.、Ishihama Yasushi、Takeuchi Osamu
- Journal Title
  
  Science Signaling
  
  Volume: 15 Issue: 729 Pages: 1-19
- DOI
  10.1126/scisignal.abm5011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H04844, KAKENHI-PUBLICLY-21H05720, KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-20H03241, KAKENHI-PROJECT-20F20115, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-21K15372, KAKENHI-PROJECT-20K22737
[Journal Article] The N6-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity2022
- Author(s)
  Yoshinaga Masanori、Han Kyuho、Morgens David W.、Horii Takuro、Kobayashi Ryosuke、Tsuruyama Tatsuaki、Hia Fabian、Yasukura Shota、Kajiya Asako、Cai Ting、Cruz Pedro H. C.、Vandenbon Alexis、Suzuki Yutaka、Kawahara Yukio、Hatada Izuho、Bassik Michael C.、Takeuchi Osamu
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 1-17
- DOI
  10.1038/s41467-022-34078-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15372, KAKENHI-PROJECT-22K15026, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-18H05278
[Journal Article] Enhancement of Regnase-1 expression with stem loop?targeting antisense oligonucleotides alleviates inflammatory diseases2022
- Author(s)
  Tse Ka Man、Vandenbon Alexis、Cui Xiaotong、Mino Takashi、Uehata Takuya、Yasuda Keiko、Sato Ayuko、Tsujimura Tohru、Hia Fabian、Yoshinaga Masanori、Kinoshita Makoto、Okuno Tatsusada、Takeuchi Osamu
- Journal Title
  
  Science Translational Medicine
  
  Volume: 14 Issue: 644 Pages: 1-14
- DOI
  10.1126/scitranslmed.abo2137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15372, KAKENHI-PROJECT-18H05278
[Journal Article] TANK prevents IFN-dependent fatal diffuse alveolar hemorrhage by suppressing DNA-cGAS aggregation2021
- Author(s)
  Wakabayashi Atsuko、Yoshinaga Masanori、Takeuchi Osamu
- Journal Title
  
  Life Science Alliance
  
  Volume: 5 Issue: 2 Pages: e202101067-e202101067
- DOI
  10.26508/lsa.202101067
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-21K15372, KAKENHI-PROJECT-20K22737
[Journal Article] がん免疫療法における免疫チェックポイント機構とマクロファージのはたらき2020
- Author(s)
  吉永正憲, 竹内理
- Journal Title
  
  Trends in Cancer Immunology
  
  Volume: 3 Pages: 3-5
- Data Source
  KAKENHI-PROJECT-20K22737
[Journal Article] Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by regnase-12020
- Author(s)
  Nakatsuka Yoshinari、Yaku Ai、Handa Tomohiro、Vandenbon Alexis、Hikichi Yuki、Motomura Yasutaka、Sato Ayuko、Yoshinaga Masanori、Tanizawa Kiminobu、Watanabe Kizuku、Hirai Toyohiro、Chin Kazuo、Suzuki Yutaka、Uehata Takuya、Mino Takashi、Tsujimura Tohru、Moro Kazuyo、Takeuchi Osamu
- Journal Title
  
  European Respiratory Journal
  
  Volume: 57 Issue: 3 Pages: 2000018-2000018
- DOI
  10.1183/13993003.00018-2020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-18H05286, KAKENHI-PROJECT-19H03488, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-20K22737, KAKENHI-PROJECT-18K15185
[Presentation] Regulation of hematopoietic cell differentiation and functions by RNA methylation2024
- Author(s)
  吉永正憲
- Organizer
  第101回日本生理学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K15372
[Presentation] The landscape of metabolic reprogramming in macrophages analyzed by genome-wide CRISPR screening2024
- Author(s)
  Shota Yasukura, Masanori Yoshinaga, Michael C Bassik, and Osamu Takeuchi
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K15372
[Presentation] RNAメチル化修飾を介した細胞機能の調節2024
- Author(s)
  吉永正憲
- Organizer
  The 3rd Kansai RNA Club
- Invited
- Data Source
  KAKENHI-PROJECT-21K15372
[Presentation] 転写後調節を介した造血・代謝制御機構2023
- Author(s)
  吉永正憲
- Organizer
  群馬大学生体調節研究所内分泌・代謝学共同研究拠点成果報告会・ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-21K15372
[Presentation] The landscape of metabolic reprogramming in macrophages analyzed by genome-wide CRISPR screening2023
- Author(s)
  Shota Yasukura, Masanori Yoshinaga, Michael C Bassik, and Osamu Takeuchi
- Organizer
  Minisymposium-Kyoto University & National Taiwan University
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15372
[Presentation] Unraveling metabolic reprogramming of macrophages through the lens of evolutionary and forward genetics2023
- Author(s)
  Masanori Yoshinaga
- Organizer
  International Symposium on Emerging RNA Viruses
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15372
[Presentation] The N6-methyladenosine transferase METTL16 enables erythropoiesis through safeguarding genome integrity2023
- Author(s)
  Masanori Yoshinaga, Michael C Bassik, and Osamu Takeuchi
- Organizer
  The 28th Annual Meeting of the RNA Society (RNA2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15372
[Presentation] The landscape of metabolic reprogramming in macrophages analyzed by genome-wide CRISPR screening2023
- Author(s)
  Shota Yasukura, Masanori Yoshinaga, Michael C Bassik, and Osamu Takeuchi
- Organizer
  JSICR/MMCB 2023 Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15372
[Presentation] 転写後調節を介した赤血球造血制御機構の解明2023
- Author(s)
  吉永正憲
- Organizer
  第18回血液学若手研究者勉強会(麒麟塾)
- Invited
- Data Source
  KAKENHI-PROJECT-21K15372
[Presentation] The landscape of metabolic reprogramming in macrophages analyzed by genome-wide CRISPR screening2023
- Author(s)
  Shota Yasukura, Masanori Yoshinaga, Michael C Bassik, and Osamu Takeuchi
- Organizer
  Minisymposium-Kyoto University & Academia Sinica
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15372
[Presentation] The N6-methyladenosine transferase METTL16 enables erythropoiesis through safeguarding genome integrity2022
- Author(s)
  Yoshinaga M, Bassik MC, and Takeuchi O
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K15372
[Presentation] The N6-methyladenosine transferase METTL16 enables erythropoiesis through safeguarding genome integrity2022
- Author(s)
  Yoshinaga M, Kawahara Y, Bassik MC, and Takeuchi O
- Organizer
  第23回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-21K15372
[Presentation] Critical role of N6-methyladenosine modification deposited by METTL16 in hematopoiesis2022
- Author(s)
  Yoshinaga M, Bassik MC, and Takeuchi O
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K15372
[Presentation] Analysis of metabolic reprogramming in macrophage utilizing genome-wide CRISPR screening2022
- Author(s)
  Yasukura S, Yoshinaga M, Bassik MC and Takeuchi O
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K15372
[Presentation] Manipulating the expressions of Regnase-1 by stem-loop-targeting-antisense oligonucleotides to counteract inflammatory diseases2021
- Author(s)
  Ka Man Tse, Xiaotong Cui, Alexis Vandenbon, Takashi Mino, Takuya Uehata, Keiko Yasuda, Ayuko Sato, Tohru Tsujimura, Fabian Hia, Masanori Yoshinaga, Osamu Takeuchi
- Organizer
  第44回日本分子生物学年会
- Data Source
  KAKENHI-PROJECT-20K22737
[Presentation] Manipulating the expressions of Regnase-1 by stem-loop-targeting-antisense oligonucleotides to counteract inflammatory diseases2021
- Author(s)
  Ka Man Tse, Xiaotong Cui, Alexis Vandenbon, Takashi Mino, Takuya Uehata, Keiko Yasuda, Ayuko Sato, Tohru Tsujimura, Fabian Hia, Masanori Yoshinaga, Osamu Takeuchi
- Organizer
  第44回日本分子生物学年会
- Data Source
  KAKENHI-PROJECT-21K15372
[Presentation] Manipulation of Regnase-1 mRNA stability by morpholino-based antisense oligonucleotides alleviates inflammatory responses in pulmonary and autoimmune diseases2021
- Author(s)
  Ka Man Tse, Xiaotong Cui, Alexis Vandenbon, Keiko Yasuda, Takuya Uehata, Ayuko Sato, Tohru Tsujimura, Takashi Mino, Masanori Yoshinaga, Tatsusada Okuno, Yoshinari Nakatsuka, Osamu Takeuchi
- Organizer
  第22回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-20K22737
[Presentation] 赤芽球分化を制御する新規転写後調節機構の解明2021
- Author(s)
  吉永正憲、竹内理
- Organizer
  第44回日本分子生物学年会
- Data Source
  KAKENHI-PROJECT-20K22737
[Presentation] Manipulation of Regnase-1 mRNA stability by antisense oligonucleotides alleviates inflammatory responses in pulmonary and autoimmune diseases2021
- Author(s)
  Ka Man Tse, Xiaotong Cui, Alexis Vandenbon, Keiko Yasuda, Takuya Uehata, Ayuko Sato, Tohru Tsujimura, Masanori Yoshinaga, Tatsusada Okuno, Yoshinari Nakatsuka, Osamu Takeuchi
- Organizer
  KAI International Meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15372
[Presentation] Analysis of metabolic reprogramming in macrophage utilizing genome-wide CRISPR screening2021
- Author(s)
  Shota Yasukura, Masanori Yoshinaga, Michael C Bassik, Osamu Takeuchi
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K15372
[Presentation] 赤芽球分化を制御する新規転写後調節機構の解明2021
- Author(s)
  吉永正憲、竹内理
- Organizer
  第44回日本分子生物学年会
- Data Source
  KAKENHI-PROJECT-21K15372
[Presentation] Manipulation of Regnase-1 mRNA stability by antisense oligonucleotides alleviates inflammatory responses in pulmonary and autoimmune diseases2021
- Author(s)
  Ka Man Tse, Xiaotong Cui, Alexis Vandenbon, Keiko Yasuda, Takuya Uehata, Ayuko Sato, Tohru Tsujimura, Masanori Yoshinaga, Tatsusada Okuno, Yoshinari Nakatsuka, Osamu Takeuchi
- Organizer
  KAI International Meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22737
[Presentation] Analysis of metabolic reprogramming in macrophage utilizing genome-wide CRISPR screening2021
- Author(s)
  Shota Yasukura, Masanori Yoshinaga, Michael C Bassik, Osamu Takeuchi
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K22737
[Presentation] Manipulation of Regnase-1 mRNA stability by morpholino-based antisense oligonucleotides alleviates inflammatory responses in pulmonary and autoimmune diseases2021
- Author(s)
  Ka Man Tse, Xiaotong Cui, Alexis Vandenbon, Keiko Yasuda, Takuya Uehata, Ayuko Sato, Tohru Tsujimura, Takashi Mino, Masanori Yoshinaga, Tatsusada Okuno, Yoshinari Nakatsuka, Osamu Takeuchi
- Organizer
  第22回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-21K15372
[Presentation] Identification of novel regulators of erythroid differentiation via genome-wide CRISPR screen2020
- Author(s)
  吉永正憲, 竹内理
- Organizer
  第１回医薬系研究交流サロン
- Data Source
  KAKENHI-PROJECT-20K22737

1. 今見考志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 竹内理

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 三野享史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 植畑拓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yoshinaga Masanori 吉永 正憲

Research Projects

Research Products

Co-Researchers

コドンバイアス認識を介した自己指向性免疫応答の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アミノ酸代謝が司る代謝リプログラミング機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

RNAメチル化修飾破綻による自己指向性免疫応答の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of erythroid differentiation by RNA methylationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Posttranscriptional regulation of iron metabolism via RNA methylationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] RNA Metabolism Governs Immune Function and Response2024

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Regulation of inflammatory diseases via the control of mRNA decay2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RNA分解酵素Regnase-1を標的とした炎症制御法の開発2023

Author(s)

Journal Title

Data Source

[Journal Article] RNA修飾が織りなす免疫制御メカニズム2023

Author(s)

Journal Title

Data Source

[Journal Article] The crossroads of RNA methylation and ferroptosis: Implications for disease pathogenesis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cyclin J-CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The N6-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhancement of Regnase-1 expression with stem loop?targeting antisense oligonucleotides alleviates inflammatory diseases2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TANK prevents IFN-dependent fatal diffuse alveolar hemorrhage by suppressing DNA-cGAS aggregation2021

Author(s)

Yoshinaga Masanori 吉永正憲