Taniguchi Keiko 谷口恵香

Researcher Number	70882942
Other IDs
Affiliation (Current)	2025: 京都府立医科大学, 医学(系)研究科(研究院), 助教
Affiliation (based on the past Project Information) *help	2025: 京都府立医科大学, 医学(系)研究科(研究院), 助教 2020 – 2023: 京都府立医科大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 58020:Hygiene and public health-related: including laboratory approach / 0908:Society medicine, nursing, and related fields Except Principal Investigator Basic Section 58020:Hygiene and public health-related: including laboratory approach / Medium-sized Section 58:Society medicine, nursing, and related fields
Keywords	Principal Investigator がん予防 / GGCT / γ-グルタミルシクロトランスフェラーゼ / スクリーニング / RB / GGCT阻害剤 / γグルタミルシクロトランスフェラーゼ / c-Met Except Principal Investigator RB / 先制医療 … More / p21 / トラメチニブ / 遺伝性乳がん卵巣がん症候群 / 予防 / がん Less

Development of preemptive medicine against hereditary breast and ovarian cancer syndrome
- Principal Investigator
  
  酒井敏行
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Kyoto Prefectural University of Medicine
A screening for GGCT inhibitor aimed to development of a novel "RB-reactivating cocktail" for cancer preventionPrincipal Investigator
- Principal Investigator
  
  谷口恵香
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Kyoto Prefectural University of Medicine
Development of preemptive medicine against RB-mutated malignancies
- Principal Investigator
  
  酒井敏行
- Project Period (FY)
  2022 – 2027
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Kyoto Prefectural University of Medicine
Development of a novel cancer prevention methods targeting GGCT by "RB reactivation screening".Principal Investigator
- Principal Investigator
  
  谷口恵香
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Kyoto Prefectural University of Medicine
Development of a novel cancer prevention methods targeting GGCT by "RB reactivation screening".Principal Investigator
- Principal Investigator
  
  Taniguchi Keiko
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0908:Society medicine, nursing, and related fields
- Research Institution
  Kyoto Prefectural University of Medicine

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Identification of c-Met as a novel target of γ-glutamylcyclotransferase2023
- Author(s)
  Saito Y, Taniguchi K, Ii H, Horinaka M, Kageyama S, Nakata S, Ukimura O, Sakai T
- Journal Title
  
  Sci Rep
  
  Volume: 13 Issue: 1 Pages: 11922-11922
- DOI
  10.1038/s41598-023-39093-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18407, KAKENHI-PROJECT-22K17350, KAKENHI-PROJECT-22K06756, KAKENHI-PROJECT-23K06642, KAKENHI-PROJECT-21K09342, KAKENHI-PROJECT-19H01079
[Journal Article] Development of an activity-based chemiluminogenic probe for γ-glutamylcyclotransferase2023
- Author(s)
  Nohara Y, Taniguchi K, Ii H, Masuda S, Kawakami H, Matsumoto M, Hattori Y, Kageyama S, Sakai T, Nakata S, Yoshiya T
- Journal Title
  
  Org Biomol Chem
  
  Volume: 21 Issue: 29 Pages: 5977-5984
- DOI
  10.1039/d3ob00655g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K18407, KAKENHI-PROJECT-22K17350, KAKENHI-PROJECT-22K06756, KAKENHI-PROJECT-23K06642, KAKENHI-PROJECT-21K09342, KAKENHI-PROJECT-19H01079
[Journal Article] Stat5b inhibition blocks proliferation and tumorigenicity of glioblastoma stem cells derived from a de novo murine brain cancer model2022
- Author(s)
  Moyama Chiami、Fujita Mitsugu、Ando Shota、Taniguchi Keiko、Ii Hiromi、Tanigawa Seisuke、Hashimoto Naoya、Nakata Susumu
- Journal Title
  
  American Journal of Cancer Research
  
  Volume: 12 Pages: 1129-1142
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K23233
[Journal Article] Stat5b inhibition blocks proliferation and tumorigenicity of glioblastoma stem cells derived from a de novo murine brain cancer model2022
- Author(s)
  Moyama C, Fujita M, Ando S, Taniguchi K, Ii H, Tanigawa S, Hashimoto N, Nakata S
- Journal Title
  
  American Journal of Cancer Research
  
  Volume: 12 Pages: 1129-1142
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K17350
[Journal Article] Salicylic acid directly binds to ribosomal protein S3 and suppresses CDK4 expression in colorectal cancer cells2022
- Author(s)
  Imai A, Horinaka M, Aono Y, Iizumi Y, Takakura H, Ono H, Yasuda S, Taniguchi K, Nishimoto E, Ishikawa H, Mutoh M, Sakai T
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 628 Pages: 110-115
- DOI
  10.1016/j.bbrc.2022.08.082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K18407, KAKENHI-PROJECT-22K17350, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-19H03889
[Journal Article] The γ-Glutamylcyclotransferase Inhibitor Pro-GA Induces an Antiproliferative Effect Through the Generation of Mitochondrial Reactive Oxygen Species2022
- Author(s)
  II HIROMI、TANIGUCHI KEIKO、YOSHIYA TAKU、NOHARA YUKIE、KAGEYAMA SUSUMU、KAWAUCHI AKIHIRO、NAKATA SUSUMU
- Journal Title
  
  Anticancer Research
  
  Volume: 42 Issue: 9 Pages: 4311-4317
- DOI
  10.21873/anticanres.15931
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K09342, KAKENHI-PROJECT-22K06756, KAKENHI-PROJECT-22K17350, KAKENHI-PROJECT-20K07623
[Journal Article] Fluorizoline blocks the interaction between prohibitin-2 and γ-glutamylcyclotransferase and induces p21Waf1/Cip1 expression in MCF7 breast cancer cells2021
- Author(s)
  Takagi Hiroko、Moyama Chiami、Taniguchi Keiko、Ando Kota、Matsuda Ryohei、Ando Shota、Ii Hiromi、Kageyama Susumu、Kawauchi Akihiro、Chouha Nora、Dёsaubry Laurent、Nakata Susumu
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 101 Issue: 2 Pages: 78-86
- DOI
  10.1124/molpharm.121.000334
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K23233, KAKENHI-PROJECT-20K07623, KAKENHI-PROJECT-21K09342
[Journal Article] γ-Glutamylcyclotransferase, a novel regulator of HIF-1α expression, triggers aerobic glycolysis2021
- Author(s)
  Taniguchi Keiko、Kageyama Susumu、Moyama Chiami、Ando Shota、Ii Hiromi、Ashihara Eishi、Horinaka Mano、Sakai Toshiyuki、Kubota Shigehisa、Kawauchi Akihiro、Nakata Susumu
- Journal Title
  
  Cancer Gene Therapy
  
  Volume: - Issue: 1 Pages: 37-48
- DOI
  10.1038/s41417-020-00287-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07623, KAKENHI-PROJECT-20K23233, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06398, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-19H03889, KAKENHI-PROJECT-19K22773, KAKENHI-PROJECT-21K09342
[Presentation] GGCTの阻害は、AMPK-STAT3-c-Met経路の抑制を介してがん抑制遺伝子RBを活性化する2024
- Author(s)
  谷口恵香, 齋藤友充子, 飯居宏美, 堀中真野, 影山進, 中田晋, 浮村理, 酒井敏行
- Organizer
  第23回分子予防環境医学研究会大会
- Data Source
  KAKENHI-PROJECT-22K18407
[Presentation] GGCTの阻害はAMPK-STAT3-c-Met経路の抑制を介してがん抑制遺伝子RBを活性化する2024
- Author(s)
  谷口恵香、齋藤友充子、飯居宏美、堀中真野、影山進、中田晋、浮村理、酒井敏行
- Organizer
  第23回分子予防環境医学研究会
- Data Source
  KAKENHI-PROJECT-22K17350
[Presentation] 膠芽腫幹細胞におけるGGCTノッダウンによる増殖抑制効果にはDhh発現の抑制が関与する2024
- Author(s)
  森昌也、嶋田絢子、白木里沙、野瀬梢、谷口恵香、藤田貢、飯居宏美、中田晋
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K17350
[Presentation] 新規がん予防標的GGCTの阻害はc-Met発現低下を介してがん細胞の増殖を抑制する2024
- Author(s)
  谷口恵香、齋藤友充子、飯居宏美、堀中真野、影山進、中田晋、浮村理、酒井敏行
- Organizer
  第94回衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-22K17350
[Presentation] 新規がん予防標的GGCTの阻害はc-Met発現低下を介してがん細胞の増殖を抑制する2024
- Author(s)
  谷口恵香, 齋藤友允子, 飯居宏美, 堀中真野, 影山進, 中田晋, 浮村理, 酒井敏行
- Organizer
  第94回日本衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-22K18407
[Presentation] Identification of c-Met as a novel target of γ-glutamylcyclotrasnferase in a prostate cancer cell line2023
- Author(s)
  齋藤友充子、谷口恵香、飯居宏美、堀中真野、影山進、中田晋、浮村理、酒井敏行
- Organizer
  第110回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-22K17350
[Presentation] Identification of c-Met as a novel target of γ-glutamylcyclotrasnferase in a prostate cancer cell line2023
- Author(s)
  齋藤友充子, 谷口恵香, 飯居宏美, 堀中真野, 影山進, 中田晋, 浮村理, 酒井敏行
- Organizer
  第110回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-22K18407
[Presentation] マウス膠芽腫幹細胞におけるGGCTノックダウンによる細胞増殖抑制に対するDesert hedgehogの関与2023
- Author(s)
  森昌也、嶋田絢子、谷口恵香、茂山千愛美、藤田貢、飯居宏美、中田晋
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K17350
[Presentation] 化学発光団 BDU を用いたがん関連 GGCT プローブ “LISA-103”の開発2023
- Author(s)
  野原由江、谷口恵香、飯居宏美、増田駿、河上紘子、松本正勝、中田晋、酒井敏行、吉矢拓
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K17350
[Presentation] 新規がん予防標的γ-グルタミルシクロトランスフェラーゼの阻害は、c-Met発現低下を介してがん細胞の増殖を抑制する2023
- Author(s)
  齋藤友充子、谷口恵香、飯居宏美、堀中真野、影山進、中田晋、浮村理、酒井敏行
- Organizer
  がん予防学術大会2023金沢 (第30回日本がん予防学会)
- Data Source
  KAKENHI-PROJECT-22K17350
[Presentation] 新規がん予防標的γ-グルタミルシクロトランスフェラーゼの阻害は、c-Met発現低下を介してがん細胞の増殖を抑制する2023
- Author(s)
  齋藤友充子, 谷口恵香, 飯居宏美, 堀中真野, 影山進, 中田晋, 浮村理, 酒井敏行
- Organizer
  がん予防学術大会2023金沢（第30回日本がん予防学会)
- Data Source
  KAKENHI-PROJECT-22K18407
[Presentation] γ-グルタミルシクロトランスフェラーゼ阻害剤pro-GAはMCF7担癌マウスにおいて抗腫瘍効果を示す2022
- Author(s)
  飯居宏美、高木寛子、谷口恵香、茂山千愛美、安藤翔太、吉矢拓、野原由江、増田駿、津田修吾、影山進、中田晋
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K23233
[Presentation] γ－グルタミルシクロトランスフェラーゼの発光基質 LISA-103 の開発2022
- Author(s)
  野原由江、谷口恵香、飯居宏美、増田駿、河上紘子、松本正勝、中田晋、酒井敏行、吉矢拓
- Organizer
  日本ケミカルバイオロジー学会第16回年会
- Data Source
  KAKENHI-PROJECT-22K17350
[Presentation] サリチル酸はヒト大腸がん細胞のRPS3に結合し、CDK4発現抑制と細胞周期のG1期停止を誘導する2022
- Author(s)
  今井綾香, 堀中真野, 青野裕一, 飯泉陽介, 高倉秀樹, 小野寿子, 谷口恵香, 安田周祐, 西幹栄美, 石川秀樹, 武藤倫弘, 酒井敏行
- Organizer
  がん予防学術大会2022
- Data Source
  KAKENHI-PROJECT-22K18407
[Presentation] サリチル酸はヒト大腸がん細胞のRPS3に結合し、CDK4発現抑制と細胞周期のG1期停止を誘導する2022
- Author(s)
  今井綾香、堀中真野、青野裕一、飯泉陽介、髙倉英樹、小野寿子、谷口恵香、安田周祐、西幹栄美、石川秀樹、武藤倫弘、酒井敏行
- Organizer
  がん予防学会学術大会2022
- Data Source
  KAKENHI-PROJECT-22K17350
[Presentation] Chemiluminecence probe LISA-103 for the detection of γ-glutamyl cyclotransferase activity2022
- Author(s)
  野原由江、谷口恵香、飯居宏美、増田駿、河上紘子、松本正勝、中田晋、酒井敏行、吉矢拓
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K17350
[Presentation] 新規がん予防標的GGCTは、がん細胞にHIF-1α発現を誘導して好気的解糖を促進する2022
- Author(s)
  谷口恵香、影山進、茂山千愛美、安藤翔太、飯居宏美、芦原英司、堀中真野、酒井敏行、窪田成寿、河内明宏、中田晋
- Organizer
  がん予防学会学術大会2022
- Data Source
  KAKENHI-PROJECT-22K17350
[Presentation] Fluorizolineによるがん細胞増殖抑制効果にはp21Waf1/Cip1誘導が関与する2022
- Author(s)
  金田裕太、茂山千愛美、吉井陸、安藤孝太、松田凌平、安藤翔太、高木寛子、谷口恵香、飯居宏美、中田晋
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K23233
[Presentation] γ-グルタミルトランスフェラーゼ阻害剤によるMCF7乳がん細胞の増殖抑制効果に対するミトコンドリアROS産生の寄与2022
- Author(s)
  飯居宏美、野瀬梢、茂山千愛美、安藤翔太、谷口恵香、吉矢拓、野原由江、影山進、中田晋
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K17350
[Presentation] 新規がん予防標的GGCTは、がん細胞にHIF-1α発現を誘導して好気的解糖を促進する2022
- Author(s)
  谷口恵香, 影山進, 茂山千愛美, 安藤翔太, 飯居宏美, 芦原英司, 堀中真野, 酒井敏行, 窪田成寿, 河内明宏, 中田晋
- Organizer
  がん予防学術大会2022
- Data Source
  KAKENHI-PROJECT-22K18407
[Presentation] 新規がん予防標的GGCTは、がん細胞にHIF-1α発現を誘導しワールブルク効果を促進する2021
- Author(s)
  谷口恵香, 影山進, 茂山千愛美, 安藤翔太, 飯居宏美, 芦原英司, 堀中真野, 酒井敏行, 窪田成寿, 河内明宏, 中田晋
- Organizer
  第20回分子予防環境医学研究会大会
- Data Source
  KAKENHI-PROJECT-20K23233
[Presentation] 新規γ-グルタミルシクロトランスフェラーゼ酵素活性阻害剤のMCF7乳がん細胞担癌マウスにおける抗腫瘍効果とそのがん細胞増殖抑制機構の解明2021
- Author(s)
  飯居宏美、高木寛子、谷口恵香、吉矢拓、影山進、中田晋
- Organizer
  第71回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-20K23233
[Presentation] FluorizolineのMCF7乳がん細胞増殖抑制効果に対するp21Waf1/Cip1誘導の寄与2021
- Author(s)
  安藤孝太、松田凌平、高木寛子、谷口恵香、飯居宏美、中田晋
- Organizer
  第71回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-20K23233
[Presentation] 新規がん予防標的GGCTは、がん細胞にHIF-1α発現を誘導して好気性解糖を促進する2021
- Author(s)
  谷口恵香, 影山進, 茂山千愛美, 安藤翔太, 飯居宏美, 芦原英司, 堀中真野, 酒井敏行, 河内明宏, 中田晋
- Organizer
  第91回日本衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-20K23233
[Presentation] GGCT阻害により誘導される乳がんまたは造血器腫瘍細胞増殖抑制はN-アセチルシステイン添加により回復する2020
- Author(s)
  飯居宏美, 谷口恵香, 高木寛子, 茂山千愛美, 安藤翔太, 芦原英司, 中田晋
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K23233

1. 酒井敏行 (20186993)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
2. 安田周祐 (10643398)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. 堀中真野 (80512037)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. 小野寿子 (50827326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 飯居宏美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 中田晋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 影山進

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 河内明宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Taniguchi Keiko 谷口 恵香

Research Projects

Research Products

Co-Researchers

Development of preemptive medicine against hereditary breast and ovarian cancer syndrome

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A screening for GGCT inhibitor aimed to development of a novel "RB-reactivating cocktail" for cancer preventionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of preemptive medicine against RB-mutated malignancies

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel cancer prevention methods targeting GGCT by "RB reactivation screening".Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel cancer prevention methods targeting GGCT by "RB reactivation screening".Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Identification of c-Met as a novel target of γ-glutamylcyclotransferase2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of an activity-based chemiluminogenic probe for γ-glutamylcyclotransferase2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stat5b inhibition blocks proliferation and tumorigenicity of glioblastoma stem cells derived from a de novo murine brain cancer model2022

Author(s)

Journal Title

Data Source

[Journal Article] Stat5b inhibition blocks proliferation and tumorigenicity of glioblastoma stem cells derived from a de novo murine brain cancer model2022

Author(s)

Journal Title

Data Source

[Journal Article] Salicylic acid directly binds to ribosomal protein S3 and suppresses CDK4 expression in colorectal cancer cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The γ-Glutamylcyclotransferase Inhibitor Pro-GA Induces an Antiproliferative Effect Through the Generation of Mitochondrial Reactive Oxygen Species2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fluorizoline blocks the interaction between prohibitin-2 and γ-glutamylcyclotransferase and induces p21Waf1/Cip1 expression in MCF7 breast cancer cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] γ-Glutamylcyclotransferase, a novel regulator of HIF-1α expression, triggers aerobic glycolysis2021

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[Presentation] GGCTの阻害は、AMPK-STAT3-c-Met経路の抑制を介してがん抑制遺伝子RBを活性化する2024

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[Presentation] GGCTの阻害はAMPK-STAT3-c-Met経路の抑制を介してがん抑制遺伝子RBを活性化する2024

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Taniguchi Keiko 谷口恵香