Zhu Bo 朱博

Researcher Number	70886605
Other IDs
Affiliation (Current)	2025: 東京科学大学, 総合研究院, 助教
Affiliation (based on the past Project Information) *help	2021 – 2024: 東京工業大学, 科学技術創成研究院, 助教
Review Section/Research Field	Principal Investigator Basic Section 27040:Biofunction and bioprocess engineering-related / Transformative Research Areas, Section (II) Except Principal Investigator Basic Section 58040:Forensics medicine-related / Basic Section 27040:Biofunction and bioprocess engineering-related
Keywords	Principal Investigator mRNA-display / 蛍光 / バイオセンサー / タンパク質 / バイオテクノロジー / NGS / Phage display / SARS-CoV-2 / Quenchbody / Immunosensor … More / phage display / mRNA display / quenchbody / uHTS / biosensor / deep learning / biomolecular display / one-pot detection / bottom-up creation / antibody conjugate … More Except Principal Investigator 法医中毒学 / 抗体ファージライブラリー / 向精神薬 / 免疫学的検出 / 薬毒物スクリーニング / 抗体 / タンパク質工学 / 機械学習 / バイオセンサー Less

機械学習を活用したユニバーサルな基盤構造創出による蛍光免疫センサーの迅速開発
- Principal Investigator
  
  北口哲也
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  Tokyo Institute of Technology
向精神薬と代謝物に対するin silico解析に基づく戦略的抗体獲得と検出法開発
- Principal Investigator
  
  笹尾亜子
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58040:Forensics medicine-related
- Research Institution
  Kumamoto University
Creatation of antiboy-peptide-nucleic acid conjugates with switch function and its application in a high-sensitive homogeneous detection systemPrincipal Investigator
- Principal Investigator
  
  朱博
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Institute of Science Tokyo
Development of a generalizable toolkit for rapidly improving the sensitivity of fluorescent immunosensor proteinsPrincipal Investigator
- Principal Investigator
  
  Zhu Bo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  Tokyo Institute of Technology

All 2023 2022 2021

All Journal Article Presentation

[Journal Article] Recent progress in homogeneous immunosensors based on fluorescence or bioluminescence using antibody engineering2023
- Author(s)
  Rani Abdul Qawee、Zhu Bo、Ueda Hiroshi、Kitaguchi Tetsuya
- Journal Title
  
  Analyst
  
  Volume: 148 Issue: 7 Pages: 1422-1429
- DOI
  10.1039/d2an01913b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K14468
[Journal Article] The Patrol Yeast: A new biosensor armed with antibody-receptor chimera detecting a range of toxic substances associated with food poisoning2023
- Author(s)
  Jiulong Su, Bo Zhu, Akihito Inoue, Hiroyuki Oyama, Izumi Morita, Jinhua Dong, Takanobu Yasuda, Yoshiko Sugita-Konishi, Tetsuya Kitaguchi, Norihiro Kobayashi, Shiro Miyake, Hiroshi Ueda
- Journal Title
  
  Biosensors and Bioelectronics
  
  Volume: 219 Pages: 114793-114793
- DOI
  10.1016/j.bios.2022.114793
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20477, KAKENHI-PROJECT-21K14468, KAKENHI-PROJECT-22KJ1271
[Journal Article] Isolation of a human SARS-CoV-2 neutralizing antibody from a synthetic phage library and its conversion to fluorescent biosensors2022
- Author(s)
  Li Haimei、Zhu Bo、Li Baowei、Chen Limei、Ning Xuerao、Dong Hang、Liang Jingru、Yang Xueying、Dong Jinhua、Ueda Hiroshi
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 15496-15496
- DOI
  10.1038/s41598-022-19699-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14468
[Journal Article] Rapid and sensitive SARS-CoV-2 detection using a homogeneous fluorescent immunosensor Quenchbody with crowding agents2022
- Author(s)
  Zhu Bo、Nosaka Nobuyuki、Kanamaru Shuji、Dong Jinhua、Dai Yancen、Inoue Akihito、Yang Yinghui、Kobayashi Kaori、Kitaguchi Tetsuya、Iwasaki Hiroshi、Koike Ryuji、Wakabayashi Kenji、Ueda Hiroshi
- Journal Title
  
  The Analyst
  
  Volume: 147 Issue: 22 Pages: 4971-4979
- DOI
  10.1039/d2an01051h
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05268, KAKENHI-PROJECT-18K05314, KAKENHI-PROJECT-21K14468, KAKENHI-PROJECT-22H00404, KAKENHI-PROJECT-22KJ1271
[Journal Article] Intra Q-body: an antibody-based fluorogenic probe for intracellular proteins that allows live cell imaging and sorting2022
- Author(s)
  Dai Yancen、Sato Yuko、Zhu Bo、Kitaguchi Tetsuya、Kimura Hiroshi、Ghadessy Farid J.、Ueda Hiroshi
- Journal Title
  
  Chemical Science
  
  Volume: 13 Issue: 33 Pages: 9739-9748
- DOI
  10.1039/d2sc02355e
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06484, KAKENHI-PLANNED-18H05527, KAKENHI-PROJECT-21K14468
[Journal Article] Creating a Thermostable β-Glucuronidase Switch for Homogeneous Immunoassay by Disruption of Conserved Salt Bridges at Diagonal Interfaces2022
- Author(s)
  Zhu Bo、Qian Cheng、Tang Haoxuan、Kitaguchi Tetsuya、Ueda Hiroshi
- Journal Title
  
  Biochemistry
  
  Volume: 62 Issue: 2 Pages: 309-317
- DOI
  10.1021/acs.biochem.2c00165
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K14468
[Journal Article] Evaluation and selection of potent fluorescent immunosensors by combining fluorescent peptide and nanobodies displayed on yeast surface2021
- Author(s)
  Inoue Akihito、Yasuda Takanobu、Zhu Bo、Kitaguchi Tetsuya、Murakami Akikazu、Ueda Hiroshi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 22590-22590
- DOI
  10.1038/s41598-021-02022-7
- NAID
  120007172601
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03851, KAKENHI-PROJECT-22KJ1271, KAKENHI-PROJECT-21K14468
[Presentation] Intra Q-body: an antibody-based fluorogenic probe for intracellular proteins that allows live-cell imaging and sorting2022
- Author(s)
  Dai Yancen, Sato Yuko, Zhu Bo, Kitaguchi Tetsuya, Kimura Hiroshi, Farid J. Ghadessy, Ueda Hiroshi
- Organizer
  Bioanalytical Sensors Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14468
[Presentation] Rapid construction of homogeneous immunosensors for SARS-CoV-2 nucleocapsid and spike proteins using Quenchbody and Quenchprobe technology2022
- Author(s)
  Bo Zhu, Haimei Li, Yancen Dai, Akihito Inoue, Yinghui Yang, Kaori Kobayashi, Tetsuya Kitaguchi, Jinhua Dong, Hiroshi Ueda
- Organizer
  Bioanalytical Sensors Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14468
[Presentation] ３分割ルシフェラーゼを用いた免疫測定法における相互作用の測定と数理モデルの作製2022
- Author(s)
  佐藤里杏人, 安田貴信, 朱博, 北口哲也, 加藤直洋, 上田宏
- Organizer
  化学工学会第88年会
- Data Source
  KAKENHI-PROJECT-21K14468
[Presentation] 蛍光免疫センサーQuenchbodyのシグナル増幅と高速スクリーニング法の探索2022
- Author(s)
  塘知子, 朱博, 北口哲也, 上田宏
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K14468
[Presentation] コルチゾール認識ナノ抗体の蛍光免疫センサー化2022
- Author(s)
  井上暁人, 鈴木大凱, YANG Yinghui, 安田貴信, 朱博, 北口哲也, 上田宏
- Organizer
  第16回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K14468
[Presentation] 酵母細胞表層提示系を用いたナノ抗体由来”nano Q-body”のTrp変異進化2022
- Author(s)
  井上暁人, 安田貴信, 朱博, 北口哲也, 村上明一, 上田宏
- Organizer
  化学工学会第88年会
- Data Source
  KAKENHI-PROJECT-21K14468
[Presentation] Converting antibodies to rapid response SARS-CoV-2 homogeneous immunosensors via Quenchbody technology and crowding agent2022
- Author(s)
  朱博, 野坂宜之, 董金華, 北口哲也, 小池竜司, 若林健二, 上田宏
- Organizer
  化学工学会第53回秋季大会
- Data Source
  KAKENHI-PROJECT-21K14468
[Presentation] Quenchbodyを用いた1分間SARS-CoV-2及び変異株の検出法2021
- Author(s)
  朱博、董金華、寧雪じょう、井上暁人、北口哲也、上田宏
- Organizer
  化学工学会第52回秋季大会
- Data Source
  KAKENHI-PROJECT-21K14468
[Presentation] 蛍光免疫プローブQuenchprobeのダブルラベル化の検討2021
- Author(s)
  小林香央里、朱博、北口哲也、上田宏
- Organizer
  化学工学会第87年会
- Data Source
  KAKENHI-PROJECT-21K14468
[Presentation] 細胞内腫瘍マーカーp53可視化のための免疫蛍光プローブQ-bodyの開発2021
- Author(s)
  Dai Yancen、朱博、佐藤優子、木村宏、Ghadessy Farid J、北口哲也、上田宏
- Organizer
  化学工学会第87年会
- Data Source
  KAKENHI-PROJECT-21K14468
[Presentation] 培養液中の組換えタンパク質が検出可能な蛍光免疫センサの構築2021
- Author(s)
  寧せつじょう、安田貴信、朱博、北口哲也、上田宏
- Organizer
  第15回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K14468
[Presentation] 蛍光免疫センサーCoiled Quenchbodyのがん光線力学療法への応用2021
- Author(s)
  椿凜果、安田貴信、朱博、北口哲也、上田宏
- Organizer
  化学工学会第87年会
- Data Source
  KAKENHI-PROJECT-21K14468

1. 北口哲也 (60432374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 坪井貴司 (80415231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 鈴木団 (40350475)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 笹尾亜子 (80284751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 安田貴信 (90963249)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 笹尾明 (30508487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 上田宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 金丸周司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 佐藤優子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Zhu Bo 朱 博

Research Projects

Research Products

Co-Researchers

機械学習を活用したユニバーサルな基盤構造創出による蛍光免疫センサーの迅速開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

向精神薬と代謝物に対するin silico解析に基づく戦略的抗体獲得と検出法開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Creatation of antiboy-peptide-nucleic acid conjugates with switch function and its application in a high-sensitive homogeneous detection systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a generalizable toolkit for rapidly improving the sensitivity of fluorescent immunosensor proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Recent progress in homogeneous immunosensors based on fluorescence or bioluminescence using antibody engineering2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Patrol Yeast: A new biosensor armed with antibody-receptor chimera detecting a range of toxic substances associated with food poisoning2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Isolation of a human SARS-CoV-2 neutralizing antibody from a synthetic phage library and its conversion to fluorescent biosensors2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rapid and sensitive SARS-CoV-2 detection using a homogeneous fluorescent immunosensor Quenchbody with crowding agents2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intra Q-body: an antibody-based fluorogenic probe for intracellular proteins that allows live cell imaging and sorting2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Creating a Thermostable β-Glucuronidase Switch for Homogeneous Immunoassay by Disruption of Conserved Salt Bridges at Diagonal Interfaces2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation and selection of potent fluorescent immunosensors by combining fluorescent peptide and nanobodies displayed on yeast surface2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] Intra Q-body: an antibody-based fluorogenic probe for intracellular proteins that allows live-cell imaging and sorting2022

Author(s)

Organizer

Data Source

[Presentation] Rapid construction of homogeneous immunosensors for SARS-CoV-2 nucleocapsid and spike proteins using Quenchbody and Quenchprobe technology2022

Author(s)

Organizer

Data Source

[Presentation] ３分割ルシフェラーゼを用いた免疫測定法における相互作用の測定と数理モデルの作製2022

Author(s)

Organizer

Data Source

[Presentation] 蛍光免疫センサーQuenchbodyのシグナル増幅と高速スクリーニング法の探索2022

Author(s)

Organizer

Data Source

Zhu Bo 朱博