MIKAME Yu 三瓶悠

… Alternative Names

三瓶悠ミカメユウ

Less

Researcher Number	70908540
Other IDs
Affiliation (Current)	2025: 東京科学大学, 生命理工学院, 助教
Affiliation (based on the past Project Information) *help	2025: 東京科学大学, 生命理工学院, 助教 2022 – 2023: 長崎大学, 医歯薬学総合研究科(薬学系), 助教
Review Section/Research Field	Principal Investigator Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Basic Section 38040:Bioorganic chemistry-related
Keywords	Principal Investigator ソラレン / 三重鎖形成核酸 / TFO / がん / DNAインターカレーター / DNA二重鎖切断 / ゲノム編集 / 光応答性機能性核酸 / 二架橋体形成 / 標的配列の拡張 … More / 1-位ソラレン導入型三重鎖形成核酸 / 相乗効果 / LNA / 三重鎖構造安定化 / ミスマッチ部位 / ソラレン導入型三重鎖形成核酸（Ps-TFO） Less

光刺激依存的な細胞死誘導を可能とする新規光応答性核酸の開発とがん治療への展開Principal Investigator
- Principal Investigator
  
  三瓶悠
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Institute of Science Tokyo
Development of novel psoralen conjugated triplex forming oligonucleotides and its application to a photo genome editing technologyPrincipal Investigator
- Principal Investigator
  
  三瓶悠
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Nagasaki University

All 2023 2022

All Journal Article Presentation Patent

[Journal Article] Unique Crosslinking Properties of Psoralen‐conjugated Oligonucleotides developed by Novel Psoralen N‐Hydroxysuccinimide Esters2023
- Author(s)
  Nakao Juki、Mikame Yu、Eshima Honoka、Yamamoto Tsuyoshi、Dohno Chikara、Wada Takehiko、Yamayoshi Asako
- Journal Title
  
  ChemBioChem
  
  Volume: - Issue: 15 Pages: 1-9
- DOI
  10.1002/cbic.202200789
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K14839, KAKENHI-PLANNED-20H05874, KAKENHI-PROJECT-22H00593, KAKENHI-PROJECT-21K18992, KAKENHI-PROJECT-23H05465
[Journal Article] Modular Synthesis of Methyl-Substituted Novel Psoralen N-Hydroxysuccinimide Esters and Evaluation of DNA Photocrosslinking Properties of the Corresponding Triplex-Forming Oligonucleotide Conjugates2023
- Author(s)
  Mikame Yu、Maekawa Nagisa、Kimura Soichiro、Yamayoshi Asako、Nakao Juki
- Journal Title
  
  Synlett
  
  Volume: -
- DOI
  10.1055/a-2229-7441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K14839, KAKENHI-PLANNED-20H05874, KAKENHI-PROJECT-22H00593
[Journal Article] 核酸医薬とゲノム編集技術2023
- Author(s)
  三瓶悠、山本剛史、山吉麻子
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 41 Pages: 635-638
- Data Source
  KAKENHI-PROJECT-22K14839
[Journal Article] ゲノムDNAを標的とした光駆動核酸の開発2023
- Author(s)
  中尾樹希、三瓶悠、山吉麻子
- Journal Title
  
  光アライアンス
  
  Volume: 34 Pages: 30-34
- Data Source
  KAKENHI-PROJECT-22K14839
[Journal Article] Development and Crosslinking Properties of Psoralen‐Conjugated Triplex‐Forming Oligonucleotides as Antigene Tools Targeting Genome DNA2023
- Author(s)
  Mikame Yu、Eshima Honoka、Toyama Haruki、Nakao Juki、Matsuo Misaki、Yamamoto Tsuyoshi、Hari Yoshiyuki、Komano Jun A.、Yamayoshi Asako
- Journal Title
  
  ChemMedChem
  
  Volume: 18 Issue: 21
- DOI
  10.1002/cmdc.202300348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K14839, KAKENHI-PLANNED-20H05874, KAKENHI-PROJECT-22H00593
[Journal Article] Recent Advancements in Development and Therapeutic Applications of Genome-Targeting Triplex-Forming Oligonucleotides and Peptide Nucleic Acids2023
- Author(s)
  Mikame Yu、Yamayoshi Asako
- Journal Title
  
  Pharmaceutics
  
  Volume: 15 Issue: 10 Pages: 2515-2515
- DOI
  10.3390/pharmaceutics15102515
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K14839, KAKENHI-PLANNED-20H05874, KAKENHI-PROJECT-22H00593
[Journal Article] Selective Photo-Crosslinking Detection of Methylated Cytosine in DNA Duplex Aided by a Cationic Comb-Type Copolymer2022
- Author(s)
  Kojima Atsuhiro、Nakao Juki、Shimada Naohiko、Yoshida Naoki、Abe Yota、Mikame Yu、Yamamoto Tsuyoshi、Wada Takehiko、Maruyama Atsushi、Yamayoshi Asako
- Journal Title
  
  ACS Biomaterials Science & Engineering
  
  Volume: 8 Issue: 5 Pages: 1799-1805
- DOI
  10.1021/acsbiomaterials.2c00048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H04558, KAKENHI-PLANNED-20H05874, KAKENHI-PROJECT-21H03816, KAKENHI-PROJECT-22K14839, KAKENHI-PROJECT-21K18992
[Journal Article] Synthesis and Evaluation of Oligonucleotide-Containing 2′-<i>O</i>-{[(4,5′,8-Trimethylpsoralen)-4′-ylmethoxy]ethylaminocarb-onyl}adenosine as Photo-crosslinkable Gene Targeting Tools2022
- Author(s)
  Mikame Yu、Sakai Yui、Tahara Ryo、Doi Kinuka、Yamamoto Tsuyoshi、Dohno Chikara、Shibata Takayuki、Yamayoshi Asako
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 70 Issue: 10 Pages: 726-730
- DOI
  10.1248/cpb.c22-00333
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2022-10-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05561, KAKENHI-PROJECT-22K14839, KAKENHI-PLANNED-20H05874, KAKENHI-PROJECT-22H00593
[Patent] 新規ソラレン類化合物2023
- Inventor(s)
  山吉麻子、三瓶悠
- Industrial Property Rights Holder
  山吉麻子、三瓶悠
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-22K14839
[Patent] 新規ソラレン類化合物2022
- Inventor(s)
  山吉麻子、三瓶悠
- Industrial Property Rights Holder
  山吉麻子、三瓶悠
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-22K14839
[Presentation] Triplex stabilizing effect and photo-crosslinking ability of a novel psoralen-conjugated triplex-forming oligonucleotide2023
- Author(s)
  Yu Mikame, Honoka Eshima, Juki Nakao, Tsuyoshi Yamamoto, Yoshiyuki Hari, Dohno Chikara, Wada Takehiko, Asako Yamayoshi
- Organizer
  7th Gratama workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K14839
[Presentation] 光架橋性基として有する新規Psoralen導入型三重鎖形成核酸のDNAへの架橋特性評価2023
- Author(s)
  木村聡一郎、前川なぎさ、中尾樹希、山吉麻子、三瓶悠
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K14839
[Presentation] 新規ソラレン導入三重鎖形成核酸によるヒト乳がん細胞への選択的な細胞死誘導効果2023
- Author(s)
  外山春樹、中尾樹希、堂野主税、和田健彦、山吉麻子、三瓶悠
- Organizer
  日本化学会第104春期年会
- Data Source
  KAKENHI-PROJECT-22K14839
[Presentation] 糖部架橋型核酸を基盤とした新規ソラレン導入型三重鎖形成核酸の開発2023
- Author(s)
  三瓶悠、外山春樹、江島穂乃香、中尾樹希、山本剛史、張功幸、堂野主税、和田健彦、山吉麻子
- Organizer
  日本核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-22K14839
[Presentation] Development of Novel Psoralen-conjugated Triplex-Forming Oligonucleotides for the Selective Death of Human Breast Cancer Cells2023
- Author(s)
  外山春樹、中尾樹希、堂野主税、和田健彦、三瓶悠、山吉麻子
- Organizer
  Supra FIBER International Summit Nucleic Acids (S-FISNA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K14839
[Presentation] Stabilization of DNA Triplex using Novel Psoralen-Introduced Triplex-Forming Oligonucleotides Enable the Induction of Stronger Cell Death of Human Breast Cancer Cells2023
- Author(s)
  Haruki Toyama, Honoka Eshima, Juki Nakao, Yu Mikame and Asako Yamayoshi
- Organizer
  ISNAC 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K14839
[Presentation] 三重鎖形成核酸の標的配列の拡張と三重鎖構造の安定化を可能とする基盤技術の開発2023
- Author(s)
  三瓶悠
- Organizer
  東北大学多元研生命有機・物理化学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-22K14839
[Presentation] 新規ソラレン導入型三重鎖形成核酸の開発と標的ゲノム配列の拡張性評価2023
- Author(s)
  三瓶悠、江島穂乃香、中尾樹希、山本剛史、張功幸、堂野主税、和田健彦、山吉麻子
- Organizer
  日本化学会第103春季年会
- Data Source
  KAKENHI-PROJECT-22K14839
[Presentation] 遺伝子発現の光制御を志向した新規ソラレン導入型三重鎖形成核酸の開発2022
- Author(s)
  三瓶悠、江島穂乃香、中尾樹希、山本剛史、堂野主税、和田健彦、山吉麻子
- Organizer
  第３回超分子薬剤学FGシンポジウム
- Data Source
  KAKENHI-PROJECT-22K14839
[Presentation] Triplex stabilizing effect and photo-crosslinking ability of a novel psoralen-conjugated triplex-forming oligonucleotide2022
- Author(s)
  Yu Mikame, Honoka Eshima, Juki Nakao, Tsuyoshi Yamamoto, Dohno Chikara, Wada Takehiko, Asako Yamayoshi
- Organizer
  ISNAC 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K14839
[Presentation] 1'位ソラレン導入型デオキシリボースを有する三重鎖形成核酸の熱力学的安定性と光架橋能の評価2022
- Author(s)
  三瓶悠、江島穂乃香、中尾樹希、山本剛史、山吉麻子
- Organizer
  日本ケミカルバイオロジー学会第16回年会
- Data Source
  KAKENHI-PROJECT-22K14839
[Presentation] 糖部1'位にソラレンを導入した新たな光架橋性ヌクレオシドの開発と三重鎖形成核酸基盤技術への展開2022
- Author(s)
  三瓶悠、江島穂乃香、中尾樹希、山本剛史、堂野主税、和田健彦、山吉麻子
- Organizer
  日本核酸医薬学会第7回年会
- Data Source
  KAKENHI-PROJECT-22K14839

1. 和田健彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MIKAME Yu 三瓶 悠

三瓶 悠 ミカメ ユウ

Research Projects

Research Products

Co-Researchers

光刺激依存的な細胞死誘導を可能とする新規光応答性核酸の開発とがん治療への展開Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel psoralen conjugated triplex forming oligonucleotides and its application to a photo genome editing technologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Unique Crosslinking Properties of Psoralen‐conjugated Oligonucleotides developed by Novel Psoralen N‐Hydroxysuccinimide Esters2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Modular Synthesis of Methyl-Substituted Novel Psoralen N-Hydroxysuccinimide Esters and Evaluation of DNA Photocrosslinking Properties of the Corresponding Triplex-Forming Oligonucleotide Conjugates2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 核酸医薬とゲノム編集技術2023

Author(s)

Journal Title

Data Source

[Journal Article] ゲノムDNAを標的とした光駆動核酸の開発2023

Author(s)

Journal Title

Data Source

[Journal Article] Development and Crosslinking Properties of Psoralen‐Conjugated Triplex‐Forming Oligonucleotides as Antigene Tools Targeting Genome DNA2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Recent Advancements in Development and Therapeutic Applications of Genome-Targeting Triplex-Forming Oligonucleotides and Peptide Nucleic Acids2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Selective Photo-Crosslinking Detection of Methylated Cytosine in DNA Duplex Aided by a Cationic Comb-Type Copolymer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis and Evaluation of Oligonucleotide-Containing 2′-<i>O</i>-{[(4,5′,8-Trimethylpsoralen)-4′-ylmethoxy]ethylaminocarb-onyl}adenosine as Photo-crosslinkable Gene Targeting Tools2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Patent] 新規ソラレン類化合物2023

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] 新規ソラレン類化合物2022

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Presentation] Triplex stabilizing effect and photo-crosslinking ability of a novel psoralen-conjugated triplex-forming oligonucleotide2023

Author(s)

Organizer

Data Source

[Presentation] 光架橋性基として有する新規Psoralen導入型三重鎖形成核酸のDNAへの架橋特性評価2023

Author(s)

Organizer

Data Source

[Presentation] 新規ソラレン導入三重鎖形成核酸によるヒト乳がん細胞への選択的な細胞死誘導効果2023

Author(s)

MIKAME Yu 三瓶悠

三瓶悠ミカメユウ