Takakura Yuki 高倉勇気

Researcher Number	70963007
Other IDs
Affiliation (Current)	2025: 千葉大学, 大学院薬学研究院, 特任研究員
Affiliation (based on the past Project Information) *help	2022 – 2024: 千葉大学, 大学院薬学研究院, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / 0801:Pharmaceutical sciences and related fields
Keywords	Principal Investigator ミトコンドリア / オートファジー / 胸腺 / がん免疫 / 自己免疫疾患 / T細胞 / 胸腺上皮細胞 / 上皮細胞 / 自己免疫

T細胞分化を司る胸腺オートファジー誘導分子の機能解析と新規がん免疫強化法への展開Principal Investigator
- Principal Investigator
  
  高倉勇気
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Chiba University
C15ORF48 is the inducing factor of thymic autophagy that regulates autoimmunity.Principal Investigator
- Principal Investigator
  
  Takakura Yuki
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0801:Pharmaceutical sciences and related fields
- Research Institution
  Chiba University

All 2024 2023 2022

All Journal Article Presentation

[Journal Article] Mitochondrial protein C15ORF48 is a stress-independent inducer of autophagy that regulates oxidative stress and autoimmunity2024
- Author(s)
  Takakura Y、Machida M、Terada N、Katsumi Y、Kawamura S、Horie K、Miyauchi M、Ishikawa T、Akiyama N、Seki T、Miyao 、Hayama Mio、Endo R、Ishii H、Maruyama Y、Hagiwara N、Kobayashi T J.、Yamaguchi N、Takano H、Akiyama T、Yamaguchi N
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1 Pages: 953-953
- DOI
  10.1038/s41467-024-45206-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06385, KAKENHI-PROJECT-20K07332, KAKENHI-PROJECT-21K06543, KAKENHI-PROJECT-21K08121, KAKENHI-PROJECT-22K20706
[Journal Article] <scp>T‐cell receptor</scp> repertoire analysis of <scp>CD4</scp>‐positive T cells from blood and an affected organ in an autoimmune mouse model2023
- Author(s)
  Ishikawa Tatsuya、Horie Kenta、Takakura Yuki、Ohki Houko、Maruyama Yuya、Hayama Mio、Miyauchi Maki、Miyao Takahisa、Hagiwara Naho、Kobayashi Tetsuya J.、Akiyama Nobuko、Akiyama Taishin
- Journal Title
  
  Genes to Cells
  
  Volume: 28 Issue: 12 Pages: 929-941
- DOI
  10.1111/gtc.13079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K19391, KAKENHI-PROJECT-23K06385, KAKENHI-PROJECT-20K07332, KAKENHI-PROJECT-22K20706
[Journal Article] VGLL3 confers slow-twitch muscle differentiation via PGC-1α expression in C2C12 myocytes2023
- Author(s)
  Takakura Yuki、Suzuki Takayuki、Hirai Naoto、Araki Takuro、Ohishi Mai、Sato Hiromi、Yamaguchi Naoto、Takano Hiroyuki、Yamaguchi Noritaka
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 669 Pages: 30-37
- DOI
  10.1016/j.bbrc.2023.05.073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06543, KAKENHI-PROJECT-21K08121, KAKENHI-PROJECT-22K20706
[Journal Article] Integrative analysis of scRNA-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator2022
- Author(s)
  Miyao T、Miyauchi M、Kelly S T、T Tommy W、Ishikawa T、Oh E、Hirai S、Horie K、Takakura Y、Ohki H、Hayama M、Maruyama Y、Seki T、Ishii H、Yabukami H、Yoshida M、Inoue A、Sakaue-Sawano A、Miyawaki A、Muratani M、Minoda A、Akiyama N、Akiyama T
- Journal Title
  
  eLife
  
  Volume: 11 Pages: 73998-73998
- DOI
  10.7554/elife.73998
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07332, KAKENHI-PROJECT-21K19391, KAKENHI-PROJECT-22K20706, KAKENHI-PLANNED-19H05754, KAKENHI-PROJECT-20H03441
[Journal Article] VGLL3 increases the dependency of cancer cells on de novo nucleotide synthesis through GART expression2022
- Author(s)
  Kawamura T., Takehora Y., Hori N., Takakura Y., Yamaguchi, N., Takano, H., and Yamaguchi, N.
- Journal Title
  
  J. Cell. Biochem.
  
  Volume: - Issue: 6 Pages: 1064-1076
- DOI
  10.1002/jcb.30251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22482, KAKENHI-PROJECT-21K06543, KAKENHI-PROJECT-21K08121, KAKENHI-PROJECT-22K20706, KAKENHI-PROJECT-22KJ0459
[Journal Article] Vestigial-like family member 3 stimulates cell motility by inducing High mobility group AT-hook 2 expression in cancer cells.2022
- Author(s)
  Hori, N., Takakura, Y., Sugino, A., Iwasawa, S., Nomizo, K., Yamaguchi, N., Takano, H., and Yamaguchi, N.
- Journal Title
  
  J. Cell. Mol. Med.
  
  Volume: - Issue: 9 Pages: 2686-2697
- DOI
  10.1111/jcmm.17279
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22482, KAKENHI-PROJECT-21K06543, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-21K08121, KAKENHI-PROJECT-22K20706, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-22KJ0459
[Presentation] 中枢性免疫寛容を抑制する胸腺オートファジー誘導機構の解析2024
- Author(s)
  高倉勇気, 秋山伸子, 高野博之, 秋山泰身, 山口憲孝
- Organizer
  第144回日本薬学会年会 (横浜, 2024.3.31）
- Data Source
  KAKENHI-PROJECT-22K20706
[Presentation] LPA刺激による脂肪細胞分化への影響の解析2023
- Author(s)
  吉田卓眞, 南須原杏律, 高倉勇気, 石川千夏, 高野博之, 山口憲孝
- Organizer
  第67回日本薬学会関東支部大会（東京, 2023.9.16）
- Data Source
  KAKENHI-PROJECT-22K20706
[Presentation] ミトコンドリアタンパク質C15ORF48によるMitophagyの抑制2023
- Author(s)
  河村星香, 高倉勇気, 勝見優香, 高野博之, 山口憲孝
- Organizer
  第67回日本薬学会関東支部大会（東京, 2023.9.16）
- Data Source
  KAKENHI-PROJECT-22K20706
[Presentation] 新規NF-κB標的遺伝子による飢餓非依存的オートファジーの誘導メカニズムと機能解明2023
- Author(s)
  高倉勇気 , 高野博之 , 山口憲孝
- Organizer
  第143年回日本薬学会
- Data Source
  KAKENHI-PROJECT-22K20706
[Presentation] 転写共役因子VGLL3によるPGC-1α発現を介した筋線維型変化の解析2023
- Author(s)
  大石まい, 高倉勇気, 高野博之, 山口憲孝
- Organizer
  第67回日本薬学会関東支部大会（東京, 2023.9.16）
- Data Source
  KAKENHI-PROJECT-22K20706
[Presentation] Stress-independent autophagy driven by a mitochondrial small protein in thymus regulates self-tolerance.2023
- Author(s)
  Yuki Takakura , Moeka Machida , Natsumi Terada , Yuka Katsumi , Hiroyuki Takano , Nobuko Akiyama , Taishin Akiyama , Noritaka Yamaguchi
- Organizer
  The 9th Global Network Forum on Infection and Immunity.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20706
[Presentation] 胸腺上皮細胞の恒常的なオートファジー誘導因子の同定2023
- Author(s)
  高倉勇気, 秋山伸子, 高野博之, 秋山泰身, 山口憲孝
- Organizer
  2023年度日本生化学会関東支部例会 (山梨, 2023.6.10）
- Data Source
  KAKENHI-PROJECT-22K20706
[Presentation] NF-κB依存的オートファジー誘導因子による細胞増殖2022
- Author(s)
  高倉勇気 , 高野博之 , 山口憲孝
- Organizer
  日本生化学会関東支部大会(千葉)
- Data Source
  KAKENHI-PROJECT-22K20706

1. YAMAGUCHI Noritaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
2. 秋山伸子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 秋山泰身

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 高野博之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takakura Yuki 高倉 勇気

Research Projects

Research Products

Co-Researchers

T細胞分化を司る胸腺オートファジー誘導分子の機能解析と新規がん免疫強化法への展開Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

C15ORF48 is the inducing factor of thymic autophagy that regulates autoimmunity.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Mitochondrial protein C15ORF48 is a stress-independent inducer of autophagy that regulates oxidative stress and autoimmunity2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] <scp>T‐cell receptor</scp> repertoire analysis of <scp>CD4</scp>‐positive T cells from blood and an affected organ in an autoimmune mouse model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] VGLL3 confers slow-twitch muscle differentiation via PGC-1α expression in C2C12 myocytes2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Integrative analysis of scRNA-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] VGLL3 increases the dependency of cancer cells on de novo nucleotide synthesis through GART expression2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Vestigial-like family member 3 stimulates cell motility by inducing High mobility group AT-hook 2 expression in cancer cells.2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] 中枢性免疫寛容を抑制する胸腺オートファジー誘導機構の解析2024

Author(s)

Organizer

Data Source

[Presentation] LPA刺激による脂肪細胞分化への影響の解析2023

Author(s)

Organizer

Data Source

[Presentation] ミトコンドリアタンパク質C15ORF48によるMitophagyの抑制2023

Author(s)

Organizer

Data Source

[Presentation] 新規NF-κB標的遺伝子による飢餓非依存的オートファジーの誘導メカニズムと機能解明2023

Author(s)

Organizer

Data Source

[Presentation] 転写共役因子VGLL3によるPGC-1α発現を介した筋線維型変化の解析2023

Author(s)

Organizer

Data Source

[Presentation] Stress-independent autophagy driven by a mitochondrial small protein in thymus regulates self-tolerance.2023

Author(s)

Organizer

Data Source

[Presentation] 胸腺上皮細胞の恒常的なオートファジー誘導因子の同定2023

Author(s)

Organizer

Data Source

[Presentation] NF-κB依存的オートファジー誘導因子による細胞増殖2022

Author(s)

Organizer

Data Source

Takakura Yuki 高倉勇気