Tsutsumi Naotaka 堤尚孝

… Alternative Names

堤尚孝ツツミナオタカ

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Researcher Number	70963495
Other IDs	https://orcid.org/0000-0002-3617-7145
Affiliation (Current)	2024: 東京科学大学, 総合研究院, 特任准教授
Affiliation (based on the past Project Information) *help	2024: 東京医科歯科大学, 高等研究院, 特任准教授 2024: 岡山大学, 医歯薬学域, 助教 2022: 岡山大学, 医歯薬学域, 助教
Review Section/Research Field	Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Basic Section 43020:Structural biochemistry-related / 0701:Biology at molecular to cellular levels, and related fields Except Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
Keywords	Principal Investigator クライオ電子顕微鏡 / 膜タンパク質 / 可溶性タンパク質 / タンパク質工学 / 難発現性タンパク質 / 難生産性タンパク質 / アレスチン / Gタンパク質 / ケモカイン / クラスA GPCR … More / 構造生物学 / GPCR / TAS2R / 苦味 / 受容体 / クライオEM … More Except Principal Investigator ハロゲンイオン / 味覚受容体 / クライオ電子顕微鏡 / バイスシグナリング / グレリン受容体 / Gタンパク質共役受容体 Less

Structural study of the initial transducer engagement by GPCRPrincipal Investigator
- Principal Investigator
  
  堤尚孝
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Okayama University
Analysis of molecular functions and physiological roles of halogen-ion sensing by T1r taste receptors
- Principal Investigator
  
  山下敦子
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Okayama University
Establishing protein engineering approaches for production of difficult-to-express proteinsPrincipal Investigator
- Principal Investigator
  
  堤尚孝
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Tokyo Medical and Dental University
Structure-function analysis of human bitter taste receptorsPrincipal Investigator
- Principal Investigator
  
  堤尚孝
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0701:Biology at molecular to cellular levels, and related fields
- Research Institution
  Okayama University
グレリン受容体のシグナル伝達選択機構の構造基盤
- Principal Investigator
  
  浅田秀基
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Kyoto University

All 2023 2022

All Journal Article Presentation Book

[Book] 実験医学2022年9月号2022
- Author(s)
  堤尚孝
- Total Pages
  4
- Publisher
  羊土社
- ISBN
  9784758125598
- Data Source
  KAKENHI-PROJECT-22K20632
[Journal Article] Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination2023
- Author(s)
  Tsutsumi Naotaka、Hwang Sunhee、Waghray Deepa、Hansen Simon、Jude Kevin M.、Wang Nan、Miao Yi、Glassman Caleb R.、Caveney Nathanael A.、Janda Claudia Y.、Hannoush Rami N.、Garcia K. Christopher
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 11
- DOI
  10.1073/pnas.2218238120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K20632
[Journal Article] Structural basis of Janus kinase trans-activation2023
- Author(s)
  Caveney Nathanael A.、Saxton Robert A.、Waghray Deepa、Glassman Caleb R.、Tsutsumi Naotaka、Hubbard Stevan R.、Garcia K. Christopher
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 3 Pages: 112201-112201
- DOI
  10.1016/j.celrep.2023.112201
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K20632
[Journal Article] Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses2022
- Author(s)
  Rosenkilde Mette M.、Tsutsumi Naotaka、Knerr Julius M.、Kildedal Dagmar F.、Garcia K. Christopher
- Journal Title
  
  Annual Review of Virology
  
  Volume: 9 Issue: 1 Pages: 329-351
- DOI
  10.1146/annurev-virology-100220-113942
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K20632
[Journal Article] Structure of the IL-27 quaternary receptor signaling complex2022
- Author(s)
  Caveney Nathanael A、Glassman Caleb R、Jude Kevin M、Tsutsumi Naotaka、Garcia K Christopher
- Journal Title
  
  eLife
  
  Volume: 11
- DOI
  10.7554/elife.78463
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K20632
[Journal Article] Organizing structural principles of the IL-17 ligand-receptor axis2022
- Author(s)
  Wilson Steven C.、Caveney Nathanael A.、Yen Michelle、Pollmann Christoph、Xiang Xinyu、Jude Kevin M.、Hafer Maximillian、Tsutsumi Naotaka、Piehler Jacob、Garcia K. Christopher
- Journal Title
  
  Nature
  
  Volume: 609 Issue: 7927 Pages: 622-629
- DOI
  10.1038/s41586-022-05116-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K20632
[Journal Article] Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation2022
- Author(s)
  Glassman Caleb R.、Tsutsumi Naotaka、Saxton Robert A.、Lupardus Patrick J.、Jude Kevin M.、Garcia K. Christopher
- Journal Title
  
  Science
  
  Volume: 376 Issue: 6589 Pages: 163-169
- DOI
  10.1126/science.abn8933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K20632
[Presentation] サイトカインと腫瘍性変異によるヤヌスキナーゼの活性化機構2023
- Author(s)
  堤尚孝
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K20632
[Presentation] Structural mechanism of Janus kinase activation2022
- Author(s)
  Naotaka Tsutsumi
- Organizer
  第20回蛋白研リトリート
- Invited
- Data Source
  KAKENHI-PROJECT-22K20632

1. 椎村祐樹 (40551297)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 浅田秀基 (20399041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 山下敦子 (10321738)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Tsutsumi Naotaka 堤 尚孝

堤 尚孝 ツツミ ナオタカ

Research Projects

Research Products

Co-Researchers

Structural study of the initial transducer engagement by GPCRPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of molecular functions and physiological roles of halogen-ion sensing by T1r taste receptors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishing protein engineering approaches for production of difficult-to-express proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structure-function analysis of human bitter taste receptorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

グレリン受容体のシグナル伝達選択機構の構造基盤

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 実験医学2022年9月号2022

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural basis of Janus kinase trans-activation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure of the IL-27 quaternary receptor signaling complex2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Organizing structural principles of the IL-17 ligand-receptor axis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] サイトカインと腫瘍性変異によるヤヌスキナーゼの活性化機構2023

Author(s)

Organizer

Data Source

[Presentation] Structural mechanism of Janus kinase activation2022

Author(s)

Organizer

Data Source

Tsutsumi Naotaka 堤尚孝

堤尚孝ツツミナオタカ