HANAOKA Kazuo 花岡一雄

Researcher Number	80010403
Other IDs
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Affiliation (based on the past Project Information) *help	2006: The University of Tokyo, JR Tokyo General Hospital, Hospital director 2002 – 2005: The University of Tokyo, The University of Tokyo Hospital, Professor, 医学部附属病院, 教授 1996 – 2001: 東京大学, 医学部・附属病院, 教授 1999: 東京大学, 医学部・付属病院, 教授 1998: 東京大学, 医学部附属病院, 教授 … More 1993 – 1995: 東京大学, 医学部(病), 教授 1991: TOKYO UNIVERSITY HOSPITAL,DEPARTMENT OF ANESTHESIOLOGY,PROFESSOR, 医学部, 教授 1990: Univ. of Tokyo Faculty of Med. Assoc. Prof., 医学部・附属病院・分院, 助教授 1990: 東京大学, 医学部・附属病院分院, 助教授 1988 – 1990: 東京大学, 医学部, 助教授 1988 – 1989: 東京大学, 医学部(分), 助教授 1988: 東京大学, 医学部(分) 1987: 東京大学, 医学部(分)講師 Less
Review Section/Research Field	Principal Investigator Anesthesiology/Resuscitation studies / 麻酔学 Except Principal Investigator Anesthesiology/Resuscitation studies / 麻酔学 / Anesthesiology/Resuscitation studies / General surgery / Radiation science
Keywords	Principal Investigator wide dynamic range (WDR) cell / dorsal horn / spinal cord / 後角 / 単一細胞活動 / 脊髄 / extracellar microelectroed measurement / calcium channel blocker / pinching stimulation / vasoactive drugs … More / single-unitactivity / 一酸化窒素 / カルシウム桔抗薬 / 脊髄鎮痛機構 / カルシウムチャネル拮抗薬 / 微小電極誘導法 / Rexed第5層型単一細胞 / クロニジン / ジルチアゼム / 脊髄疼痛制御機構 / 細胞外電位測定 / カルシウムチャンネル遮断薬 / つまみ刺激 / 血管作動薬 / 広域作動性細胞 / extracellular microelectrode measurement / PaCO_2 / pinching stimulus / hyperventilation / single-unit activity / Paco_2 / ペアン鉗子ピンチ法 / 誘発発射 / 自発発射 / Wide dynamic range neuron / 脊髄後角単一細胞 / wide dynamic range / 細胞外微小電極誘導法 / PaCO2 / ピンチ刺戟 / 過換気 / wide dynamic range(WDR)cell' / ブトルファノール / 脊髄後角Reced第5層型単一細胞 / ブトルファノ-ル / ペンタゾシン / フェンタニル / ブプレノルフィン / 麻薬性鎮痛薬 / 拮抗性鎮痛薬 / 微小電極記録法 / 脊髄後角Rexed第5層型単一細胞 … More Except Principal Investigator 脊髄 / 吸入麻酔薬 / MK-801 / U50488H / クロニジン / NMDA receptor / NMDA受容体 / Bispectral Index / Spinal evoked potential / 選択的後根ブロック / 脊髄誘発電位 / 脊髄内視鏡 / halothane / 筋弛緩モニタ- / 薬力学 / 薬物動態学 / 非脱分極性筋弛緩薬 / computer / model / inhalational agents / epidural / diethylether / エーテル / ゼノン / ファ-マコキネティクス / コンピュ-タ / モデル / 硬膜外麻酔 / エ-テル / ハロセン / Morphine Tolerance / Lactoferrin / Mesaconitine / Processed Aconiti Tuber / Sokei-Kakketsu-to / Herbal Medicine / 修治附子末 / 真武湯 / 桂枝加朮附湯 / 圧刺激 / 熱刺激 / 修治ブシ末 / 坐骨神経部分損傷モデル / ラットCCIモデル / モルヒネ耐性 / ラクトフェリン / メサコニチン / 修治附子 / 疎経活血湯 / 漢方薬 / antipruritic effect / analgesia / dexmedetomidine / clonidine / α2アドレナリン受容体作動薬 / 仕痒効果 / 止痒効果 / 鎮痛効果 / デクスメデトミジン / acetylcholine receptor / GABA_A receptor / α_2 receptor / AMPA receptor / Rat / Analgesia / Spinal cord / α_2受容体 / セトロニン受容体 / グルタミン酸受容体 / GABA受容体 / 脊随 / ミダゾラム / セロトニン受容体 / アセチルコリン受容体 / AMPA受容体 / α2受容体 / GABA_A受容体 / ラット / 鎮痛 / Inhalational anesthetics / spinal dorsal horn neuron / Nitric Oxide / L-NAME / 一酸化窒素(NO) / WDR神経細胞 / 吸入麻酔 / 脊髄後角 / 脊髄後角細胞 / 一酸化窒素 / excitatory amino acid receptor / metabotropic receptor / non-NMDA receptor / intrinsic analgesia / spinal cord / hyperventilation / methysergide / フェントラミン / ナロキソン / 興奮性アミノ酸受容体 / metabotropic受容体 / 非NMDA受容体 / 内因性鎮痛機構 / 過換気 / protective effect / resuscitation / adenosine / 低血圧 / 内皮障害 / 冠動脈れん縮 / 心筋保護 / 虚血 / 保護効果 / 蘇生 / アデノシン / Internet / Remote control / Closed-loop control / Vecuronium / Fentanyl / Propofol / Total intravenous anesthesia / 遠隔制御 / コンピュータ・ネットワーク / 自動制御 / フィードバック / 麻酔深度モニター / Bispcctral Index / インターネット / 遠隔操作 / Closed-Loop Control / ベクロニウム / フェンタニル / プロポフォール / 完全静脈麻酔 / Selective root blockade / Spinal endoscopy / 神経根ブロック / regulation / mobile accelerator / IORT / X周波数帯加速管 / 放射線障害防止法 / 電子線 / 移動型電子線照射装置 / 管理区域 / 漏洩線量 / 医療法 / 可動型電子線照射装置 / 術中照射 / Selective dorsal root blockade / Spinal cndoscopy / 選択的神経根ブロック / cell culture / enflurane / sevoflurane / isoflurane / inhalational anesthetics / hepatic carcinoma cells / 死滅度 / イソフルラン / 揮発性麻酔薬暴露 / ラット肝癌細胞 / 細胞培養 / ハロタン / エンフルラン / セボフルラン / インフルシン / 肝癌細胞 / DIGITAL FILTER / SHEINER'S MODEL / MONITOR / SINGLE TWITCH / PLASMA CONCENTRATION / PHARMACODYNAMICS / PHARMACOKINETICS / MUSCLE RELAXANTS / 非線形最小2乗法 / 外挿分布容積 / Sheinerのモデル / ディジタルフィルタ / 単収縮高 / 筋弛緩モニター / 最小2乗法 / オンライン / PC-9801 / テタヌス刺激後増強(PTP) / テタヌス刺激後促通(PTF) / ペクロニウム / パンクロニウム / テタヌス収縮 / 筋弛緩薬 / テタヌス反応 / 四連反応 / 単収縮 / 血中濃度 / コンプライアンス / 抵抗 / CPAP / PSV / SIMV / 患者仕事量 / 呼吸筋 / 機械換気 Less

Effects of alpha 2 adrenoceptors or opioid receptors on spinal analgesiaPrincipal Investigator
- Principal Investigator
  
  SEKIYAMA Hiroshi, 花岡一雄
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  The University of Tokyo
Study on Efficacy and Mechanism of Herbal Medicine in Neuropathic Pain
- Principal Investigator
  
  ARITA Hideko
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  The University of Tokyo
Investigation of the network of analgesic mechanisms in the spinal cord
- Principal Investigator
  
  NISHIYAMA Tomoki
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  The University of Tokyo
The effects of inhalational anesthetics and NO upon activities of spinal dorsal horn neuron
- Principal Investigator
  
  IDE Yasuo, 角田俊信
- Project Period (FY)
  1999 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  The University of Tokyo
SELECTIVE DORSAL ROOT BLOCKADE USING SPINAL ENDOSCOPY AND ELECTRO-PHYSIOLOGY
- Principal Investigator
  
  CHINZEI Mieko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  THE UNIVERSITY OF TOKYO
THE EFFECT OF VASOACTIVE DRUGS UPON THE SPINAL PAIN MODULATIONPrincipal Investigator
- Principal Investigator
  
  HANAOKA Kazuo
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  The University of Tokyo
Development of a remote-controlled, automated total intravenous anesthesia system
- Principal Investigator
  
  YAMAMOTO Hirotoshi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  The University of Tokyo
Protective effects of adenosine Dreconditioning for cardiac arres
- Principal Investigator
  
  KOMATSU Kyoko
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University Tokyo
The Involvement of NMDA receptor in the intrinsic analgesia evoked by hyperventilation
- Principal Investigator
  
  IDE Yasuo
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  The University of Tokyo
Development of a new mobile accelerator for IORT
- Principal Investigator
  
  AOKI Yukimasa, 佐々木康人
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Radiation science
- Research Institution
  University of Tokyo
呼吸筋活動から観た呼吸不全患者に対する機械換気とウィーニングの連続的研究
- Principal Investigator
  
  山田芳嗣
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  The University of Tokyo
The Effects of Hyperventilation upon the Spinal Pain Modulating SystemPrincipal Investigator
- Principal Investigator
  
  HANAOKA Kazuo
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  UNIVERSTY OF TOKYO
The Effects of Inhalational Anesthetics on Cancer Cells-Carcinostatic Effects of Inhalational Anesthetics-
- Principal Investigator
  
  ARITA Hideko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Tokyo
A BASIC STUDY ON THE DEVELOPEMENT OF NEW TECHNIQUE FOR SELECTIVE DORSAL ROOT BLOCKADE USING SPINAL ENDOSCOPY
- Principal Investigator
  
  CHINZEI Mieko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  TOKYO UNIVERSITY
DEVELOPMENT OF A NEW THEORY FOR ESTIMATING PHARMACOKINETIC AND PHARMACODYNAMIC PARAMETERS OF NEUROMUSCULAR BLOCKING AGENTS.
- Principal Investigator
  
  YAJIMA Choku
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  麻酔学
- Research Institution
  TOKYO UNIVERSITY
筋弛緩薬の薬物動態学および薬力学のパラメ-タの新しい推定法の開発
- Principal Investigator
  
  YAJIMA Choku
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  麻酔学
- Research Institution
  The University of Tokyo
Epioural Anesthesthesia Using Inhalational Agents
- Principal Investigator
  
  SUWA Kunio
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  麻酔学
- Research Institution
  The University of Tokyo
各種中枢性拮抗性鎮痛薬と麻薬性鎮痛薬・拮抗性鎮痛薬の鎮痛効果に対する相互作用についてPrincipal Investigator
- Principal Investigator
  
  花岡一雄
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  麻酔学
- Research Institution
  The University of Tokyo

All 2007 2006 2005 2004

All Journal Article

[Journal Article] Effects of Topical Application of Clonidine Cream on Pain Behaviors and Spinal Fos Protein Expression in Rat Models of Neuropathic Pain2007
- Author(s)
  Li C, Sekjyama H, Hayashida M, Takeda K, Sumida T, Sawamura S, Yamada Y, Arita H, Hanaoka K
- Journal Title
  
  Anesthesiology 107(3)
  
  Pages: 486-94
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390470
[Journal Article] Inhibitory effect of processed Aconiti tuber on the development of antinociceptive tolerance to morphine : evaluation with a thermal assay2007
- Author(s)
  Shu H, Hayashida M, Chiba S, Sekiyama H, Kitamura T, Yamada Y, Hanaoka K, Arita H
- Journal Title
  
  J Ethnopharmacol 113(3)
  
  Pages: 560-3
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390470
[Journal Article] Effects of Topical Application of Clonidine Cream on Pain Behaviors and Spinal Fos Protein Expression in Rat Models of Neuropathic Pain2007
- Author(s)
  Li C, Sekiyama H, Hayashida M, Takeda K, Sumida T, Sawamura S, Yamada Y, Arita H, Hanaoka K
- Journal Title
  
  Anesthesiology 107(3)
  
  Pages: 486-94
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390470
[Journal Article] Inhibition of morphine tolerance by processed Aconiti tuber is mediated by kappa-opioid receptors2006
- Author(s)
  Shu H, Arita H, Hayashida M, Chiba S, Sekiyama H, Hanaoka K
- Journal Title
  
  J Ethnopharmacol 27
  
  Pages: 398-405
- Data Source
  KAKENHI-PROJECT-15390470
[Journal Article] Inhibition of morphine tolerance by processed Aconiti tuber is mediated through activation of kappa opioid receptors.2006
- Author(s)
  Shu H, Arita H, Hayashida M, Chiba S, Sekiyama H, Hanaoka K
- Journal Title
  
  Journal of Ethnopharmacology Jan 27(Epub ahead of print)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591618
[Journal Article] Effect of repeated topical application of clonidine cream in a rat model of postoperative pain2006
- Author(s)
  Li C, Sekiyama S, Hayashida M, Sumida T, Arita H, Hanaoka K
- Journal Title
  
  PAIN RESEARCH 21(1)
  
  Pages: 25-32
- NAID
  10017332641
- Data Source
  KAKENHI-PROJECT-15390470
[Journal Article] Effects of deep hypothermic circulatory arrest with retrograde cerebral perfusion on electroencephalographic bispectral index and suppression ratio2006
- Author(s)
  Hayashida M, Sekiyama H, Orii R, Chinzei M, Ogawa M, Arita H, Hanaoka K, Takamoto S.
- Journal Title
  
  Journal of cardiothoracic and vascular anesthesia 21(1)
  
  Pages: 61-7
- Data Source
  KAKENHI-PROJECT-15390470
[Journal Article] Inhibition of morphine tolerance by processed Aconiti tuber is mediated by kappa-opioid receptors2006
- Author(s)
  Shu H, Arita H, Hayashida M, Chiba S, Sekiyama H, Hanaoka K
- Journal Title
  
  J Ethnopharmacol. 106(2)
  
  Pages: 263-71
- Data Source
  KAKENHI-PROJECT-15390470
[Journal Article] Effect of repeated topical application of clonidine cream in a ratmodel of postoperative pain2006
- Author(s)
  Li C, Sekiyama S, Hayashida M, Sumida T, Arita H, Hanaoka K
- Journal Title
  
  PAIN RESEARCH 21(1)
  
  Pages: 25-32
- NAID
  10017332641
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390470
[Journal Article] Effects of processed Aconiti tuber and its ingredient alkaloids on the development of antinociceptive tolerance to morphine.2006
- Author(s)
  Shu H, Arita H, Hayashida M, Sekiyama H, Hanaoka K
- Journal Title
  
  Journal of Ethnopharmacology 103
  
  Pages: 398-405
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591618
[Journal Article] Pain-relieving effects of processed Aconiti tuber in CCI-neuropathic rats.2006
- Author(s)
  Xu H, Arita H, Hayashida M, Zhang L, Sekiyama H, Hanaoka K
- Journal Title
  
  Journal of Ethnopharmacology 103
  
  Pages: 392-397
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591618
[Journal Article] Pain-relieving effects of processed Aconiti tuber in CCI-neuropathic rats2005
- Author(s)
  Xu H, Arita H, Hayashida M, Zhang L, Sekiyama H, Hanaoka K
- Journal Title
  
  J Ethnopharmacol 103(3)
  
  Pages: 392-397
- Data Source
  KAKENHI-PROJECT-15390470
[Journal Article] Rob for cyclooxygenase 2 in the development and maintenance of neuropathic pain and spinal glial activation2005
- Author(s)
  Takeda K, Sawamura S, Tamai H, Sekiyama H, Hanaoka K
- Journal Title
  
  Anesthesiology 103(4)
  
  Pages: 837-44
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390470
[Journal Article] Role for cyclooxygenase 2 in the development and maintenance of neuropathic pain and spinal glial activation2005
- Author(s)
  Takeda K, Sawamura S, Tamai H, Sekiyama H, Hanaoka K
- Journal Title
  
  Anesthesiology 103(4)
  
  Pages: 837-44
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390470
[Journal Article] Effects of processed Aconiti tuber and its ingredient alkaloids on the development of antinociceptive tolerance to morphine2005
- Author(s)
  Shu H, Arita H, Hayashida M, Sekiyama H, Hanaoka K
- Journal Title
  
  J Ethnopharmacol 103(3)
  
  Pages: 398-405
- Data Source
  KAKENHI-PROJECT-15390470
[Journal Article] Efficacy of prophylactic intravenous granisetron in postoperative emesis in adults2004
- Author(s)
  Hanaoka K
- Journal Title
  
  J Anesth. 18・3
  
  Pages: 158-158
- NAID
  10013428985
- Data Source
  KAKENHI-PROJECT-15390470
[Journal Article] The Effect of Methylprednisolone on Neuropathic Pain and Spinal Glial Activation in Rats2004
- Author(s)
  Takeda K, Sawamura S, Sekiyama S, Tamai H, Hanaoka K
- Journal Title
  
  Anesthesiology 100(5)
  
  Pages: 1249-57
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390470

1. TAGAMI Megumi (90107657)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
2. IDE Yasuo (60193463)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
3. SUMIDA Toshinobu (80187806)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
4. SEKIYAMA Hiroshi (40301105)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
5. YAJIMA Choku (20191108)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. CHINZEI Mieko (30165097)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. ABE Yuusuke (90193010)

# of Collaborated Projects: 2 results

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8. CHINZEI Tsuneo (20197643)

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9. YAMAMURA Hideo (60009884)

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10. SUGAI Naosuke (10010563)

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11. ARITA Hideko (10114357)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
12. AOKI Yukimasa (40143474)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. KITAMURA Takayuki (50302609)

# of Collaborated Projects: 2 results

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14. TAMAI Hisayoshi (00272592)

# of Collaborated Projects: 2 results

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15. MABUTI Kunihiko (50192349)

# of Collaborated Projects: 1 results

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16. HIRAOKA Masahiro (70173218)

# of Collaborated Projects: 1 results

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17. NAGAWA Hirokazu (80228064)

# of Collaborated Projects: 1 results

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18. SAITO Hideaki (30134555)

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19. NAKAGAWA Keiichi (80188896)

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20. FUJIMASA Iwao (30010028)

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21. YAMAMOTO Hirotoshi (30292931)

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22. NAGATA Osamu (10260283)

# of Collaborated Projects: 1 results

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23. KOMATSU Kyoko (20261993)

# of Collaborated Projects: 1 results

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24. NISHIYAMA Tomoki (70272581)

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25. SUWA Kunio (50010202)

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26. 山田芳嗣 (30166748)

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27. 長瀬真幸 (70172533)

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28. 佐々木康人 (80081694)

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29. 澤田俊夫 (50143441)

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30. 小林寛伊 (50010244)

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31. 小倉信 (50185568)

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32. 鈴木聡

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33. 川俣和博

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34. 北村享之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HANAOKA Kazuo 花岡 一雄

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Effects of alpha 2 adrenoceptors or opioid receptors on spinal analgesiaPrincipal Investigator

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THE EFFECT OF VASOACTIVE DRUGS UPON THE SPINAL PAIN MODULATIONPrincipal Investigator

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The Effects of Hyperventilation upon the Spinal Pain Modulating SystemPrincipal Investigator

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HANAOKA Kazuo 花岡一雄