KUNIEDA Takehisa 國枝武久

… Alternative Names

国枝武久クニエダタケヒサ

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Researcher Number	80012649
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Affiliation (based on the past Project Information) *help	2011: 崇城大学, 薬学部, 教授 2005: Sojo Univ., Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 2004 – 2005: 崇城大学, 薬学部, 教授 2003: Kumamoto University, Graduate School of Medical and Pharmaceutical Sciences, Professor, 大学院・医学薬学研究部, 教授 1987 – 2002: Faculty of Pharmaceutical Sciences, Kumamoto University, 薬学部, 教授 1986: 熊本大, 薬学部, 教授
Review Section/Research Field	Principal Investigator Chemical pharmacy / 医薬分子機能学 / Drug development chemistry Except Principal Investigator 医薬分子機能学
Keywords	Principal Investigator 不斉補助剤 / 2-オキサゾロン / 2-オキサゾリジノン / 2-Oxazolidinone / 2-Oxazolone / アミノアルコール / 2-Imidazolidinone / 2-イミダゾリジノン / キラル合成子 / スメクチック液晶 … More / 2-アミノアルコール / 液晶 / 不斉配位子 / 2-Imidazolone / 2-イミダゾロン / Chiral auxiliary / Asymmetric synthesis / 等方性 / ネマチック液晶 / 不斉合成 / スタチン / 不斉Diels-Alder反応 / 2-チアゾリン / 水素移動型不斉還元 / 不斉アルキル化 / 2-Amino alcohol / 熱反応 / 光学分割 / 不斉還元 / Asymmetric Diels-Alder reaction / Asymmetric transfer hydrogenation / Asymmetric alkylation / Kinetic resolution / 2-Thiazolidinone / 2-チアゾリジノン / 触媒的光学分割 / Kinetic Resolution / Chiral Ligands / Chiral Auxiliaries / 人工不斉源 / 速度論的光学分割 / Chiral synthesis / 1、2-ジアミン / Chiral Synthesis / Statine / 水酸化グルタミン酸 / リン酸化試薬 / 分子間環化反応 / 立体選択性 / 分子内熱環化反応 / 光延反応 / コレステリック液晶 / ラジカル環化反応 / メソ型環状ジカルボン酸無水物 / 1,4-付加反応 / イミダゾリジノン / オキサゾリジノン / ウラシル光二量化 / Diels-Alder反応 / 反応制御 / 液晶反応場 / Mixed phosphotriester / Beta-Latam / Hydroxy-glutamic acid / Amino alcohol / Chiral synthon / テロメリ化反応 / 生理活性アミノアルコール / 合成試薬 / 混合リン酸トリエステル / β-ラクタム / Catalytic dissymmetrization / 不斉アルキル化反応 / 触媒的不斉化 / ラセミックスイッチ / イミノチオエーテル / 水素移動型不斉還元反応 / 1,2-ジアミン / 屋根付き / 触媒的不均斉化 / 2-Thiazoline / アミノチオール / ジアミン / 2-チアゾロン / 屋根付不斉源 / 水素移動型不還元 / Orientation regulation / Mitsunobu reaction / Intermolecular cycloaddition / Intramolecular cycloaddition / cholesteric phase / Smectic phase / Liquid crystal / 不斉触媒反応 / 不均斉化 / 不斉脱アセチル化 / スメクチック相 / ラジカル付加 / セレノメトキシ化 / ブロモメトキシ化 / 複素五員環化合物 / 不斉機能化 / 熱環化反応 / 分子内環化反応 / コレスレリック液晶 / スメクチック結晶 / 分子配向制御 / Bis(oxazoline) ligand / 不斉モノ脱アシル化 / メソ体 / オキサザボロリジン / ビスオキサゾリン / 不斉反応試薬 / 不斉制御能 / aldol反応 / Michael反応 / Aldol反応 / Asymmetric reduction / Hydroxy amino acid / アルドール反応 / 水酸化アミノ酸 / オキサゾロン / Condensing reagent / 2-Amino alchol / チオリン酸 / 2ーオキサゾリドン / 2ーオキサゾロン / 2ーアミノアルコ-ル / 縮合剤 / 機能性液晶 / 高選択的高効率反応 / 親ジエンコレステック液晶 / ステアリン酸ブチルエステル / 液晶媒体 / β-ラクタム合成試薬 / キラル補助剤 / ヒスチジン / アミノ酸のDNP誘導体 / 高分解能FABーMS / 逆相中圧カラムクロマトグラフィ- / 多孔性合成吸着剤 / 抗カビ抗生物質 / ペプチド抗生物質 / ヒスチジノマイシン / DNA変異 / DNA修飾 / 人工核酸 / 分子内Diels-Alder反応 / 脱離反応 / 熱多分子反応 / ニトロン / [3+2]環化反応 / [4+2]環化反応 / マクロライド / 3連続不斉中心 / 立体選択的制御 / 位置選択的制御 / DielsーAlder反応 / 液晶親ジエン剤 / 液晶ジエノフィル / 光2量化反応 / 合成子 / ベスタチン / ケトピン酸 / 2-アミノアルコ-ル … More Except Principal Investigator synthesic chemistry / drug design / new compounds / drug binding site / cardiac calsium channel / photoaffinity labeling / calcium antagonist / 心筋L型Caチャンネル / 精密合成化学 / 精密合成科学 / ドラッグデザイン / 新規化合物 / 薬物結合部位 / 心筋Caチャンネル / 光アフィニティラベリング / Ca拮抗薬 / 結晶構造 / ピエゾクロミズム / 液晶相反応 / ジオレフィン化合物 / ジアセチレン化合物 / 固相反応 / 立体選択的反応 / 分子性結晶 Less

G:C→A:T変異を誘導する人工核酸ツールの開発Principal Investigator
- Principal Investigator
  
  國枝武久
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Sojo University
Development of highly efficient asymmetric synthesis process directed for "racemic switch" of the racemic medicinesPrincipal Investigator
- Principal Investigator
  
  KUNIEDA Takehisa
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Sojo University
Liquid Crystal Control of uni-to multi-molecular Thermal ReactionsPrincipal Investigator
- Principal Investigator
  
  KUNIEDA Takehisa
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
Highly efficient asymmetric synthesis process directed for optically pure medicinesPrincipal Investigator
- Principal Investigator
  
  KUNIEDA Takehisa
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
液晶反応場による分子認識:新コンセプトに基づく特異的反応制御手法の開拓Principal Investigator
- Principal Investigator
  
  国枝武久
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
液晶反応場による分子認識:新コンセプトに基づく特異的反応制御手法への展開Principal Investigator
- Principal Investigator
  
  國枝武久
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
液晶反応場による分子認識:特異的反応制御と新規方法論への展開Principal Investigator
- Principal Investigator
  
  國枝武久
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
複素環系不斉補助剤を基盤とした精密な不斉制御空間の構築と不斉触媒反応への展開Principal Investigator
- Principal Investigator
  
  KUNIEDA Takehisa
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
液晶反応場による特異的反応制御と新規方法論への展開Principal Investigator
- Principal Investigator
  
  國枝武久
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
Chiral Processes towards Effective Synthesis of Optically Active DrugsPrincipal Investigator
- Principal Investigator
  
  KUNIEDA Takehisa
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
ラジカル環化反応を鍵とする多連続不斉中心構造の効率構築法の開発Principal Investigator
- Principal Investigator
  
  國枝武久
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
液晶反応場による特異的反応制御:新規方法論創出への展開Principal Investigator
- Principal Investigator
  
  國枝武久
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
Drug binding in cardiac calcium channels : Identification and its application to drug development
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
Highly Effective Chirality Controlling Systems.Principal Investigator
- Principal Investigator
  
  KUNIEDA Takehisa
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
Development of Efficient Chiral Synthetic Process of Bioactive Compounds.Principal Investigator
- Principal Investigator
  
  KUNIEDA Takehisa
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
高性能不斉補助剤の開発と応用Principal Investigator
- Principal Investigator
  
  國枝武久
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
高性能不斉補助剤の開発と応用Principal Investigator
- Principal Investigator
  
  國枝武久
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
高性能不斉補助剤の開発と応用Principal Investigator
- Principal Investigator
  
  國枝武久
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
Asymmetric Synthesis and Molecular Design of Peptidic Renin InhibitorsPrincipal Investigator
- Principal Investigator
  
  KUNIEDA Takehisa
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
Development of Novel Chiral Synthons for 2-Amino Alcohols of Biological Interest.Principal Investigator
- Principal Investigator
  
  KUNIEDA Takehisa
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University.
液晶構造に基づく高選択的高効率化学変換反応の設計Principal Investigator
- Principal Investigator
  
  国枝武久
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
複素環骨格の反応特性を利用する生理活性物質合成Principal Investigator
- Principal Investigator
  
  國枝武久
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
液晶を反応の場とする高選択的・高効率化学変換反応Principal Investigator
- Principal Investigator
  
  國枝武久
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
結晶場を利用した立体選択的反応の設計
- Principal Investigator
  
  甲斐泰
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
高い抗カビ活性をもつ新ペプチド抗生物質ヒスチジノマイシンの精製法の改良と構造解析Principal Investigator
- Principal Investigator
  
  金田幸, 國枝武久
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Hiroshima University
  Kumamoto University
液晶を反応の場とする高選択的高効率化学変換反応Principal Investigator
- Principal Investigator
  
  國枝武久
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
多官能性汎用合成素子の開発と生理活性物質合成への応用Principal Investigator
- Principal Investigator
  
  国枝武久
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kumamoto University
Facile Synthesis of Bioactive Amino Alcohols Utilizing 2-Oxazolone HeterocyclePrincipal Investigator
- Principal Investigator
  
  KUNIEDA Takehisa
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University

All 2011 2005 2004

All Journal Article Presentation Book

[Book] Part B, Chapter 5. "Synthesis and Reaction of 2(3H)-Oxazolones and 2(5H)-Oxazolones" in Chemistry of Heterocyclic Compounds(ed. by David C.Palmer)2004
- Author(s)
  Kunieda, T.
- Total Pages
  52
- Publisher
  John Wiley & Sons, Inc., New York
- Data Source
  KAKENHI-PROJECT-16590084
[Book] Part B, Chapter 5. "Synthesis and Reaction of 2(3H)-Oxazolones and 2(5H)-Oxazolones" in Chemistry of Heterocyclic Compounds (ed. by David C. Palmer)2004
- Author(s)
  Kunieda, T.
- Total Pages
  52
- Publisher
  John Wiley & Sons, Inc., New York
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590084
[Journal Article] Synthetic utility of five-membered heterocycles-chiral functionalization and applications2005
- Author(s)
  Kunieda, T.
- Journal Title
  
  Tetrahedron 61
  
  Pages: 8073-8094
- Data Source
  KAKENHI-PROJECT-16590084
[Journal Article] Highly efficient asymmetric transfer hydrogenation of ketones catalyzed by chiral ′roofed′ cis-diamine-Ru(II)complex2005
- Author(s)
  Kunieda, T.
- Journal Title
  
  Tetrahedron Letters 46
  
  Pages: 3645-3648
- NAID
  130006996413
- Data Source
  KAKENHI-PROJECT-16590084
[Journal Article] Sterically Congested "Roofed" 2-Thiazolines as New Chirai Ligands for Copper(II)-Catalyzed Asymmetric Diels-Alder Reactions2005
- Author(s)
  Kunieda, T.
- Journal Title
  
  Tetrahedron Letters 46
  
  Pages: 4019-4022
- Data Source
  KAKENHI-PROJECT-16590084
[Journal Article] Sterically congested "roofed" 2-iminothioethers as new chiral ligands for palladium-catalyzed asymmetric allylic alkylation2005
- Author(s)
  Kunieda, T.
- Journal Title
  
  Heterocycles 66
  
  Pages: 135-141
- Data Source
  KAKENHI-PROJECT-16590084
[Journal Article] Part B, Chapter 5. Synthesis and Reaction of 2(3H)-Oxazolones and 2(5H)-Oxazolones (pp 1-52).2004
- Author(s)
  Kunieda, T., et al.
- Journal Title
  
  Chemistry of Heterocyclic Compounds(ed. by David C.)(Palmer, John Wiley & Sons, Inc.)(New York)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590084
[Journal Article] Catalytic dissymmetrization of meso-2-imidazolidinones : alternative route to chiral synthons for 1,2-diamines2004
- Author(s)
  Kunieda, T.
- Journal Title
  
  Tetrahedron Letters 45
  
  Pages: 9327-9330
- Data Source
  KAKENHI-PROJECT-16590084
[Journal Article] Enantioselective synthesis of (1S,2S)-1,2-di-tert-butyl and (1R,2R)-1,2-di(1-adamantyl)ethylenediamines2004
- Author(s)
  Kunieda, T.
- Journal Title
  
  Tetrahedron Letters 45
  
  Pages: 8073-8077
- Data Source
  KAKENHI-PROJECT-16590084
[Presentation] グアニン6位酸素との架橋反応を目指した人工核酸塩基の開発2011
- Author(s)
  井本修平、千國友子、永次史、寒冰壽朗、國枝武久
- Organizer
  第28回日本薬学会九州支部大会
- Place of Presentation
  福岡
- Year and Date
  2011-12-11
- Data Source
  KAKENHI-PROJECT-23659060

1. ISHIZUKA Tadao (60176203)

# of Collaborated Projects: 19 results

# of Collaborated Products: 0 results
2. MATSUNAGA Hirohumi (10274713)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
3. NAGAMATSU Tomohisa (40155966)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. DALY John W.

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. NAKAYAMA Hitoshi (70088863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KUNIYASU Akihiko (90241348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SAKUMA Yoshiharu (70040318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 甲斐泰 (40029236)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 菅原正 (50124219)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 奥山健二 (30038020)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 岩崎不二子 (10017329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 長谷川正木 (50133103)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 寒水壽朗 (90412733)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 井本修平 (20447189)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 金田幸 (40019675)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 中村昭四郎 (40013304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TAKAMURA Norio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. BCHWARTZ Arnold

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. OHZEKI Masakatsu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. ARITA Masafumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. DALY Johm.W

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. GLOSSMANN Ha

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KUNIEDA Takehisa 國枝 武久

国枝 武久 クニエダ タケヒサ

Research Projects

Research Products

Co-Researchers

G:C→A:T変異を誘導する人工核酸ツールの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of highly efficient asymmetric synthesis process directed for "racemic switch" of the racemic medicinesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Liquid Crystal Control of uni-to multi-molecular Thermal ReactionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Highly efficient asymmetric synthesis process directed for optically pure medicinesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

液晶反応場による分子認識:新コンセプトに基づく特異的反応制御手法の開拓Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

液晶反応場による分子認識:新コンセプトに基づく特異的反応制御手法への展開Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

液晶反応場による分子認識:特異的反応制御と新規方法論への展開Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

複素環系不斉補助剤を基盤とした精密な不斉制御空間の構築と不斉触媒反応への展開Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

液晶反応場による特異的反応制御と新規方法論への展開Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chiral Processes towards Effective Synthesis of Optically Active DrugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ラジカル環化反応を鍵とする多連続不斉中心構造の効率構築法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

液晶反応場による特異的反応制御:新規方法論創出への展開Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Drug binding in cardiac calcium channels : Identification and its application to drug development

Principal Investigator

Project Period (FY)

Research Category

KUNIEDA Takehisa 國枝武久

国枝武久クニエダタケヒサ