SEINO Yoshiki 清野佳紀

… Alternative Names

清野佳紀セイノヨシキ

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Researcher Number	80028620
External Links
Affiliation (Current)	2025: 大阪保健医療大学, 大阪保健医療大学, 名誉教授
Affiliation (based on the past Project Information) *help	2001 – 2002: Okayama University, Graduate School of Medicine and Dentistry, Professor, 大学院・医歯学総合研究科, 教授 1990 – 2000: 岡山大学, 医学部, 教授 1989: 大阪大学, 医学部, 助教授 1987 – 1988: 大阪大学, 医学部, 講師 1986: 阪大, 医学部, 講師
Review Section/Research Field	Principal Investigator Pediatrics / Endocrinology / 内分泌・代謝学 / Kidney internal medicine / Biological Sciences Except Principal Investigator Pediatrics / Metabolomics / 内分泌・代謝学 / Endocrinology / Biomedical engineering/Biological material science / Pathological medical chemistry
Keywords	Principal Investigator 器官培養 / 1,25(OH)_2D_3 / secondary hyperparathyroidism / 遺伝子多型 / ビタミンD受容体 / propeptide of pro-osteocalcin / intact osteocalcin / N-terminal osteocalcin / 骨形成 / ビタミンD … More / 軟骨細胞 / stat-1 / ATDC-5 / PTHrP / 軟骨無形成症 / FGFR3 / 遺伝子変異 / 骨 / receptor / 1α-ハイドロキシラーゼ / 1.25(OH)_2D_3 / クル病 / リセプター / bcl-2 / VPRKO / 変異FGFR3 / IGF-I / 細胞死 / 線維芽細胞成長因子受容体3 / 成長軟骨 / apoptosis / Bcl-2 / IGF-1 / inositol tris phosphate / intracellular calcium / polymorphism / calcium sensing receptor / IP_3 / HEK293 / 強制発現 / カルシウム感受性受容体 / 家族性低カルシウム尿性高カルシウム血症 / 新生児重症副甲状腺機能亢進症 / 副甲状腺ホルモン / 慢性腎不全 / 2次性副甲状腺機能亢進症 / 変異 / 糖尿病性腎症 / 副甲状腺機能亢進症 / イノシトール-3-リン酸 / 細胞内カルシウム / カルシウム感知受容体 / 二次性副甲状腺機能亢進病 / gene polymorphism / vitamin D receptor / 腎性骨異栄養症(ROD) / 2次性副甲状腺機能亢進症(2ﾟHPT) / IGF結合蛋白(IGFBP) / ビタミンD受容体(VDR) / 骨密度 / 二次性副甲状腺機能亢進症 / growth hormone / bone resorption / bone formation / hypopituitaric dwarfism / normal children / プロペプタイド / オステオカルシン / 成長ホルモン / 骨吸収 / 下垂体性小人症 / 正常小児 / propeptide of Pro-osteocalcin / intact Osteocalcin / Osteoporosis / Bone Formation / 1 alpha, 25-(OH)_2D_3-26, 23-lactone / Vitamin D / ビタミンDラクトン体 / 骨粗鬆症 / ピタミンDラクトン体 / cbfa 1 / アロマターゼ / 24,25-dihydroxyvitamin D / ビタミンD受容体ノックアウトマウス / 24,25(OH)2D3 / VDRKO / 1,25dihydroxyvitamin D / cbfa1 / runx2 / 移植 / 骨幹部 / VDRKOマウス / FGFR-3 / Stat-1 / CFK2 / sprouty2 / 変異導入マウス / ATDC5 / shp2 / アデノウィルス / KDEL / stat1 / PLCγ / PTH / トランスジェニックマウス / 低リン血症性ビタミンD抵抗性くる病 / RT-PCR / EBウィルス / PEX / Hyp / リン / P(H)EX遺伝子 / 骨髄移植 / Hypマウス / 家族性低リン血症性ビタミンD抵抗性くる病 … More Except Principal Investigator FGF23 / PTH / PHEX / XLH / Hyp / Hypマウス / 家族性低リン血症性ビタミンD抵抗性くる病 / M-CSF / 破骨細胞 / 軟骨細胞 / 低身長 / 骨芽細胞 / IGFBP-3 / ビタミンD / bone growth / FGFR3 / achondroplasia / Stat1 / 骨成長障害 / STAT1 / FGF receptor 3 / アポトーシス / 骨成長 / 副甲状腺ホルモン / 線維芽細胞増殖因子受容体3型 / 軟骨無形成症 / GSα / McCune-Albright Syndrome / phosphatonin / apoptpsis / 低リン血症性くる病 / Fanconi症候群 / FGFR / 腫瘍性骨軟化症 / cAMP / Gsα / McCune-Albright症候群 / vitamin D / bone marrow transplantation / X-linked hypophosphatemic vitamin D resistant rickets / リン利尿因子 / 家族性低リン血症性ビタミン抵抗性くる病 / Phex / phex / 骨髄移植 / 低リン血症性ビタミンD抵抗性くる病 / cell adhesion / integrin / tyrosine phosphorylation / signal transduction / osteoclast precursors / マクロファージコロニー刺激因子 / 細胞接着因子 / 細胞外マトリックス / 信号伝達系 / 細胞接着 / インテグリン / リン酸化チロシン / シグナル伝達 / 破骨細胞前駆細胞 / 輸入・輸出細動脈 / 糸球体 / CCD生体顕微鏡 / カルシウム拮抗薬 / 輸出入細動脈 / 糸球体病態生理 / 高血圧 / 糖尿病 / 虚血再灌流 / 毛細血管可視化 / 腎糸球体微小血管 / 骨粗鬆症 / 骨系統疾患 / 骨格系 / IGF-1 / 非内分泌性低身長 / 部分的ホルモン分泌不全 / 古典的ホルモン分泌不全 / 成長ホルモン分泌不全 / 成長ホルモン / ビタミンD受容体 / 単クローン抗体 / セコステロール骨格 / Ca^<2+>依存性蛋白キナーゼ / IGFBP-4 / IGF / cDNA / モノクロ-ナル抗体 / 受容体 / 低リンマウス / 低リンクル病 Less

Research on the function of the responsible genes for hypophosphatemic vitamin D resistant rickets and their pathogenetic mechanisms.
- Principal Investigator
  
  TANAKA Hiroyuki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Okayama University
Molecular basis on bone growth disturbance : Novel treatment for achondroplasia
- Principal Investigator
  
  INOUE Masaru
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Okayama University
病態モデル小動物における腎糸球体微小循環可視化法の開発と病態生理学的解析
- Principal Investigator
  
  梶谷文彦
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Okayama University
骨系統疾患における軟骨骨化制御に関する研究-軟骨無形成症の病態解明・治療開発Principal Investigator
- Principal Investigator
  
  田中弘之, 清野佳紀
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Okayama University
ビタミンD代謝物の新しい情報伝達機構に関する研究Principal Investigator
- Principal Investigator
  
  清野佳紀
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Endocrinology
- Research Institution
  Okayama University
Mechanism of Bone Growth : Research on proliferation and apoptosis of growth plate chondrocyte.Principal Investigator
- Principal Investigator
  
  SEINO Yoshiki
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Endocrinology
- Research Institution
  Okayama University
骨格系の制御プログラムと疾患
- Principal Investigator
  
  松本俊夫
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
Interaction of cytokines and cell adhesion molecules during osteoclastogenesis
- Principal Investigator
  
  INOUE Masaru
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  OKAYAMA UNIVERSITY
Studies on the function of responsible gene, PHEX, for X-linked hypophosphatemic vitamin D resistant rickets - Search for novel phosphate regulating systems
- Principal Investigator
  
  TANAKA Hiroyuki
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  OKAYAMA UNIVERSITY
Pathophysiologic mechanisms of the abnormal parathyroid hormone secretionPrincipal Investigator
- Principal Investigator
  
  SEINO Yoshiki
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  OKAYAMA UNIVERSITY
低リン血症性ビタミンD抵抗性くる病の遺伝子の解析と蛋白機能の解析Principal Investigator
- Principal Investigator
  
  清野佳紀
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  内分泌・代謝学
- Research Institution
  Okayama University
The roles of vitamin D and growth factors in the pathogenesis of renal osteodystrophyPrincipal Investigator
- Principal Investigator
  
  SEINO Yoshiki
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Okayama University
ビタミンDの新しい情報受容機構に関する研究
- Principal Investigator
  
  田中弘之
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Okayama University
骨におけるインスリン様成長因子及びその結合蛋白の分泌・作用調節機構に関する研究
- Principal Investigator
  
  久保俊英
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Okayama University
骨におけるIGFおよびその結合蚕白の作用と調節機構に関する研究
- Principal Investigator
  
  TANAKA Hiroyuki
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Okayama University
Serum Propeptide and Intact Molecular Osteocalcin in Normal Children and Children with Growth Hormone(GH) DeficiencyPrincipal Investigator
- Principal Investigator
  
  SEINO Yoshiki
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Okayama University
ビタミンD抵抗性クル病におけるビタミンD受容体のcDNAによる分子生物学的解析
- Principal Investigator
  
  YAMAOKA Kanji
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Osaka University
1alpha, 25 - (OH)_2 D_3 - 26, 23 - lactone stimulates bone formation.Principal Investigator
- Principal Investigator
  
  SEINO Yoshiki
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Okayana University
  Osaka University
Measurement of 1,25(OH)_2D_3 receptors in vitamin D resistant diseases.Principal Investigator
- Principal Investigator
  
  SEINO Yoshiki
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University

All 2005 2004

All Journal Article Book

[Book] 骨の病気と付き合うには -本人と家族のために-2004
- Author(s)
  清野佳紀監修, 山中良孝編
- Total Pages
  237
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-14570747
[Journal Article] An effective case of Growth hormone Treatment on Cartilage-hair hypoplasia.2005
- Author(s)
  D Harada, Y Yamanaka, K Ueda, J Shimizu. M Inoue, Y Seino, H Tanaka
- Journal Title
  
  Bone
- Data Source
  KAKENHI-PROJECT-14370337
[Journal Article] An effective case of growth hormone treatment on cartilage-hair hypoplasia.2005
- Author(s)
  Harada D, Yamanaka Y, Ueda K, Shimizu J, Inoue M, Seino Y, Tanaka H.
- Journal Title
  
  Bone 36(2)
  
  Pages: 317-322
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370337
[Journal Article] Development of novel therapy for achondroplasia : Use of parathyroid hormone.2005
- Author(s)
  Yamanaka Y, Tanaka H, Harada D, Ueda K, Seino Y.
- Journal Title
  
  Clinical Pediatric Endocrinology. (Suppl 23) 14
  
  Pages: 39-44
- NAID
  130004430956
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370337
[Journal Article] An effective case of Growth hormone Treatment on Cartilage-hair hypoplasia.2005
- Author(s)
  D Harada, Y Yamanaka, K Ueda, J Shimizu, M Inoue, Y Seino, H Tanaka.
- Journal Title
  
  Bone
- Data Source
  KAKENHI-PROJECT-12137206
[Journal Article] Direct action of 1,25-dihydroxyvitamin D on bone : VDRKO bone shows excessive bone formation in normal mineral condition2004
- Author(s)
  Hiroyuki Tanaka, Yoshiki Seino
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology 89・343
  
  Pages: 343-345
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570747
[Journal Article] Direct action of 1,25-dihydroxyvitamin D on bone ; VDRKO bone shows excessive bone formation in normal mineral condition.2004
- Author(s)
  Tanaka H.Seino Y.
- Journal Title
  
  J Steroid Biochem Mol Biol 89-90
  
  Pages: 343-345
- Data Source
  KAKENHI-PROJECT-14370337
[Journal Article] Direct action of 1,25-dihydroxyvitamin D on bone ; VDRKO bone shows excessive bone formation in normal mineral condition.2004
- Author(s)
  Tanaka H, Seino Y.
- Journal Title
  
  J Steroid Biochem Mol Biol 89-90
  
  Pages: 343-345
- Data Source
  KAKENHI-PROJECT-12137206
[Journal Article] Direct action of 1,25-dihydroxyvitamin D on bone : VDRKO bone shows excessive bone formation in normal mineral condition2004
- Author(s)
  Hiroyuki Tanaka, Yoshiki Seino
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology 89
  
  Pages: 343-345
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570747
[Journal Article] Direct action of 1, 25-dihydroxyvitamin D on bone: VDRKO bone shows excessive bone formation in normal mineral condition2004
- Author(s)
  Hiroyuki Tanakana, Yoshiki Seino
- Journal Title
  
  The Journal of Steroid Biochemistry and. Molecular Biology 89・343
  
  Pages: 343-345
- Data Source
  KAKENHI-PROJECT-14570747

1. TANAKA Hiroyuki (80231413)

# of Collaborated Projects: 17 results

# of Collaborated Products: 9 results
2. INOUE Masaru (20253023)

# of Collaborated Projects: 13 results

# of Collaborated Products: 3 results
3. KUBO Toshihide (50252961)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. YAMANAKA Yoshitaka (60346442)

# of Collaborated Projects: 5 results

# of Collaborated Products: 5 results
5. KANZAKI Susumu (90224873)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. MORIWAKE Tadashi (40243505)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
7. YAMAOKA Kanji (60144490)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. KUROSE Hirofumi (60192043)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. SATOMURA Kenichi (60178796)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. NINOMIYA Shinsuke (10325110)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 松本俊夫 (20157374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 高岡邦夫 (30112048)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 加藤茂明 (60204468)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 山口朗 (00142430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 中村利孝 (50082235)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 梶谷文彦 (70029114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 清水壽一郎 (80294403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 荒木淳一 (80271055)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 小笠原康夫 (10152365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 毛利聡 (00294413)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 入部玄太郎 (90284885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 小田慈 (50160875)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 石田允 (50112032)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. SHIMA Masaaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 大薗恵一

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SEINO Yoshiki 清野 佳紀

清野 佳紀 セイノ ヨシキ

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骨系統疾患における軟骨骨化制御に関する研究-軟骨無形成症の病態解明・治療開発Principal Investigator

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ビタミンD代謝物の新しい情報伝達機構に関する研究Principal Investigator

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Mechanism of Bone Growth : Research on proliferation and apoptosis of growth plate chondrocyte.Principal Investigator

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Pathophysiologic mechanisms of the abnormal parathyroid hormone secretionPrincipal Investigator

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低リン血症性ビタミンD抵抗性くる病の遺伝子の解析と蛋白機能の解析Principal Investigator

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The roles of vitamin D and growth factors in the pathogenesis of renal osteodystrophyPrincipal Investigator

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SEINO Yoshiki 清野佳紀

清野佳紀セイノヨシキ