OHNISHI Yoshitaka 大西克尚

Researcher Number	80037473
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2000 – 2005: 和歌山県立医科大学, 医学部, 教授 1997: 和歌山県立医科大学, 医学部, 教授 1995 – 1997: 和歌山県立医科大学, 医学部・眼科, 教授 1989 – 1992: 九州大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator Ophthalmology / Ophthalmology Except Principal Investigator Ophthalmology
Keywords	Principal Investigator transforming growth factor / XPC knockout mouse / トランスフォーミング成長因子 / XPCノックアウトマウス / 直早期遺伝子 / 猿 / 電子顕微鏡 / マクロファ-ジ / 眼内レンズ / cyclopamine … More / Sonic hedgehog / squamous cell carcinoma / gene therapy / Ocular malignant tumor / シクロパミン / ソニックヘッジホッグ / 扁平上皮癌 / 遺伝子治療 / 眼部悪性腫瘍 / activating protein 1 / oncogene / anti-oncogene / ocular tumor / 癌抑制遺伝子 / がん制御遺伝子 / がん遺伝子 / がん抑制遺伝子 / 眼腫瘍 / photosensitizer / hematoporphyrin derivative / photodynamic therapy / bleomycin / eyelid tumor / electroporation / elecrtrochemotherapy / 光感受性物質 / ヘマトポルフィリン誘導体 / 光線力学的療法 / ブレオマイシン / 眼瞼腫瘍 / 電気穿孔器 / 電撃化学療法 / レ-ザ-フレアセルメ-タ- / ポリメチルメタクリレ-ト / 人工水晶体 / マクロファージ / ポリメチルメタクリレート / シリコン / 白内障 / フィブリン / 家兎 / 好中球 / 多核巨細胞 … More Except Principal Investigator Macrophage / Transmission electron microscopy / Collagen fiber / Anterior capsule opacification / Lens epithelial cell / Fibrous opacification / After cataract / Intraocular lens / トレ-サ- / フィブロネクチン / マイクロフィラメント / マクロファ-ジ / 膠原線維 / 前嚢混濁 / 線維性混濁 / フィブリン / 透過型電子顕微鏡 / 後発白内障 / 水晶体上皮細胞 / 血液房水柵 / 多核巨細胞 / マクロファージ / 眼内レンズ Less

Significance of transforming growth factors for ocular malignant tumors and their application in gene therapy.Principal Investigator
- Principal Investigator
  
  OHNISHI Yoshitaka
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Wakayama Medical University
Experimental study on anti-oncogene and oncogene in eye disordersPrincipal Investigator
- Principal Investigator
  
  OHNISHI Yoshitaka
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Wakayama Medical University
Experimental study on multidisciplinary treatment for malignant tumors of the eye.Principal Investigator
- Principal Investigator
  
  OHNISHI Yoshitaka
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Wakayama Medical College
マクロファージを指標とし判定した各種素材眼内レンズの組織適合性に関する実験的研究Principal Investigator
- Principal Investigator
  
  大西克尚
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Kyushu University
CELLULAR REACTION AROUND THE INTRAOCULAR LENSES
- Principal Investigator
  
  ISHIBASHI Tatsuro
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  KYUSHU UNIVERSITY
眼内レンズ挿入眼におけるマクロファ-ジの働きに関する実験的研究Principal Investigator
- Principal Investigator
  
  大西克尚
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Kyushu University

All 2005 2004 2003

All Journal Article

[Journal Article] Transcriptional activation in lens epithelial cells following an ocular blunt trauma.2005
- Author(s)
  Shirai K, Saika S, Okada Y, Miyamoto T, Ueyama T, Ohnishi Y.
- Journal Title
  
  J Catract Refract Surg. 31(6)
  
  Pages: 1226-1230
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] Inhibition of p38MAP kinase suppresses fibrotic reaction of retinal pigment epithelial cells.2005
- Author(s)
  Saika S, Yamanaka O, Ikeda K, Kim-Mitsuyama S, Flanders KC, Yoo J, Roberts AB, Nishikawa-Ishida I, Ohnishi Y, Muragaki Y, Ooshima A.
- Journal Title
  
  Lab Invest. 85(7)
  
  Pages: 838-850
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] 細胞増殖調節機構の解明と治療への応用2005
- Author(s)
  大西克尚等
- Journal Title
  
  日本眼科学会雑誌 109・12
  
  Pages: 865-884
- NAID
  10018628825
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] Growth factor deposition in anterior subcapsular cataract.2005
- Author(s)
  Ishida I, Saika S, Okada Y, Ohnishi Y.
- Journal Title
  
  J Cataract Refract Surg. 31(6)
  
  Pages: 1219-1225
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] 細胞増殖調節機構の解明と治療への応用2005
- Author(s)
  大西克尚, 等
- Journal Title
  
  日本眼科学会雑誌 109・12
  
  Pages: 865-884
- NAID
  10018628825
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] Therapeutic effects of adenoviral gene transfer of bone morphogenic protein-7 on a corneal alkali injury model in mice.2005
- Author(s)
  Saika S, Ikeda K, Yamanaka O, Flanders KC, Nakajima Y, Miyamoto T, Ohnishi Y, Kao WW, Muragaki Y, Ooshima A.
- Journal Title
  
  Lab Invest. 85(4)
  
  Pages: 474-486
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] Investigation of mechanism of cell prolixferation regulation and its clinical application.2005
- Author(s)
  Ohnishi Y, Saika S, Yamanaka O, Okada Y, Shirai K, Miyamoto T, Nishikawa I, Tanaka T, Miyazaki K.
- Journal Title
  
  Nippon Ganka Gakkai Zasshi 109(12)
  
  Pages: 865-884
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] Therapeutic effect of topical administration of SN50, an inhibitor of nuclear factor-kappaB, in treatment of corneal alkali burns in mice.2005
- Author(s)
  Saika S, Miyamoto T, Yamanaka O, Kato T, Ohnishi Y, Flanders KC, Ikeda K, Nakajima Y, Kao WW, Sato M, Muragaki Y, Ooshima A.
- Journal Title
  
  Am J Pathol. 166(5)
  
  Pages: 1393-1403
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] Expression of Smad7 in mouse eyes accelerates healing of corneal tissue after exposure to alkali.2005
- Author(s)
  Saika S, Ikeda K, Yamanaka O, Miyamoto T, Ohnishi Y, Sato M, Muragaki Y, Ooshima A, Nakajima Y, Kao WW, Flanders KC, Roberts AB.
- Journal Title
  
  Am J Pathol. 166(5)
  
  Pages: 1405-1418
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] Smad3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury.2004
- Author(s)
  Saika S, Kono-Saika S, Ohnishi Y, Sato M, Muragaki Y, Ooshima A, Flanders KC, Yoo J, Anzono M, Lu C-Y, Kao WW-Y, Roberts AB.
- Journal Title
  
  Am J Pathol. 164(2)
  
  Pages: 651-663
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] Fibroblast growth factor 2 : Roles of regulation of lens cell proliferation and epithelial-mesenchymal transition in response to injury.2004
- Author(s)
  Tanaka T, Saika S, Ohnishi Y, Ooshima A, McAvoy JW, Liu C-Y, Azhar M, Doetschman T, Kao WW-Y.
- Journal Title
  
  Molecular Vision 10(7)
  
  Pages: 462-467
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] Fibroblast growth factor 2 : roles of regulation of lens cell proliferation and epithelial-mesenchymal transition in response to injury.2004
- Author(s)
  Tanaka T, Saika S, Ooshima A, Ohnishi Y
- Journal Title
  
  Mol Vis 15・10
  
  Pages: 462-467
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] Novel complex GUCY2D mutation in Japanese family with cone-rod dystrophy.2004
- Author(s)
  Ito S, Nakamura M, Nuno Y, Ohnishi Y, Nishida T, Miyake Y.
- Journal Title
  
  Invest Ophthalmol Vis Sci. 45(5)
  
  Pages: 1480-1485
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] Deposition of silicone oil droplets in the residual anterior lens capsule after vitrectomy and lensectomy in rabbits.2004
- Author(s)
  Miyamoto T, Saika S, Yamanaka A, Okada Y, Ohnishi Y
- Journal Title
  
  Br J Ophthalmol 88・5
  
  Pages: 703-707
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] Expression of c-Fos and c-Jun in developing mouse lens.2004
- Author(s)
  Shirai K, Saika S, Okada Y, Senba E, Ohnishi Y
- Journal Title
  
  Ophthalmic Res 36・4
  
  Pages: 226-230
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] Smad3 is required for dedifferentiation of retinal pigment epithelium following retinal detachment in mice.2004
- Author(s)
  Saika S, Kono-Saika S, Tanaka T, Yamanaka O, Sato M, Ohnishi Y
- Journal Title
  
  Lab Invest 84・10
  
  Pages: 1245-1258
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] Expression patterns of beta1-related alpha integrin subunits in murine lens during embryonic development and wound healing.2004
- Author(s)
  Barbour W, Saika S, Miyamoto T, Ohkawa K, Utsunomiya H, Ohnishi Y
- Journal Title
  
  Curr Eye Res 29・1
  
  Pages: 1-10
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] Deposition of silicone oil droplets in the residual anterior lens capsule after vitrectomy and lensectomy in rabbits.2004
- Author(s)
  Miyamoto T, Saika S, Yamanaka A, Okada Y, Ohnishi Y
- Journal Title
  
  Br J Ophthalmol. 88(5)
  
  Pages: 703-707
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] Role of p38 MAP kinase in regulation of cell migration and proliferation in healing corneal epithelium.2004
- Author(s)
  Saika S, Okada Y, Miyamoto T, Yamanaka O, Ohnishi Y, Ooshima A, Liu C-Y, Weng D, Kao WW-Y.
- Journal Title
  
  Invest Ophthalmol Vis Sci. 45(1)
  
  Pages: 100-109
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] Sonic hedgehog expression and role in healing corneal epithelium.2004
- Author(s)
  Saika S, Muragaki Y, Okada Y, Miyamoto T, Ohnishi Y, Ooshima A, Kao WW-Y.
- Journal Title
  
  Invest Ophthalmol Vis Sci. 45(8)
  
  Pages: 2577-2585
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] Expression of cyclooxygenase-2 in corneal cells after photorefractive keratectomy and laser in situ keratomileusis in rabbits.2004
- Author(s)
  Miyamoto T, Saika S, Okada Y, Kawashima Y, Sumioka T, Fujita N, Suzuki Y, Yamanaka A, Ohnishi Y
- Journal Title
  
  J Cataract Refract Surg. 30(12)
  
  Pages: 2612-2617
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] Sonic hedgehog expression and role in healing corneal epithelium.2004
- Author(s)
  Saika S, Muragaki Y, Okada Y, Miyamoto T, Ooshima A, Ohnishi Y
- Journal Title
  
  Invest Ophthalmol Vis Sci 45・8
  
  Pages: 2577-2585
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] AP-1 (c-Fos/c-Jun) is required for corneal epithelial spreading.2003
- Author(s)
  Okada Y, Saika S, Shirai K, Hashizume N, Miyamoto T., Yamanaka O, Ohnishi Y, Miyajima M, Senba E.
- Journal Title
  
  Graefes Arch Clin Exp Ophthalmol. 241(4)
  
  Pages: 330-333
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] Osteopontin : a component of matrix in capsular opacification and subcapsular cataract.2003
- Author(s)
  Saika S, Miyamoto T, Ishida I, Ohnishi Y, Ooshima A.
- Journal Title
  
  Invest Ophthalmol Vis Sci 44(4)
  
  Pages: 1622-1628
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] Transcriptional activation in lens epithelial cells after anterior capsule rubbing in rats : expression of c-Fos.2003
- Author(s)
  Shirai K, Saika S, Okada Y, Senba E, Ohnishi Y.
- Journal Title
  
  J Cataract Refract Surg. 29(8)
  
  Pages: 1601-1604
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] Response of lens epithelial cells to injury : role of lumican in epithelial-mesenchymal transition.2003
- Author(s)
  Saika S, Miyamoto T, Tanaka S, Tanaka T, Ishida I, Ohnishi Y, Ooshima A, Ishiwata T, Asano G, Chikama T-I, Shiraishi A, Liu C-Y, Kao CW-C, Kao WW-Y.
- Journal Title
  
  Invest Ophthalmol Vis Sci 44(5)
  
  Pages: 2094-2102
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] Effects of ineterferon-g on human subconjunctival fibroblasts in the presence of TGFb1 : reversal of TGFb-stimulated collagen production.2003
- Author(s)
  Yamanaka O, Saika S, Okada Y, Ooshima A, Ohnishi Y.
- Journal Title
  
  Graefes Arch Clin Exp Ophthalmol 241(2)
  
  Pages: 116-124
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591873
[Journal Article] Expression of AP-1 (c-fos/c-jun) in developing mouse corneal epithelium.2003
- Author(s)
  Okada Y, Saika S, Shirai K, Ohnishi Y, Senba E.
- Journal Title
  
  Graefes Arch Clin Exp Ophthalmol. 241(4)
  
  Pages: 327-329
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591873

1. ISHIBASHI Tatsuro (30150428)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. OKADA Yuka (50264891)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
3. KAWANO Yoh-ichi (90211185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OHNISHI Yoshitaka 大西 克尚

Research Projects

Research Products

Co-Researchers

Significance of transforming growth factors for ocular malignant tumors and their application in gene therapy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Experimental study on anti-oncogene and oncogene in eye disordersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Experimental study on multidisciplinary treatment for malignant tumors of the eye.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

マクロファージを指標とし判定した各種素材眼内レンズの組織適合性に関する実験的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

CELLULAR REACTION AROUND THE INTRAOCULAR LENSES

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

眼内レンズ挿入眼におけるマクロファ-ジの働きに関する実験的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Transcriptional activation in lens epithelial cells following an ocular blunt trauma.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Inhibition of p38MAP kinase suppresses fibrotic reaction of retinal pigment epithelial cells.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] 細胞増殖調節機構の解明と治療への応用2005

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Growth factor deposition in anterior subcapsular cataract.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] 細胞増殖調節機構の解明と治療への応用2005

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Therapeutic effects of adenoviral gene transfer of bone morphogenic protein-7 on a corneal alkali injury model in mice.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Investigation of mechanism of cell prolixferation regulation and its clinical application.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Therapeutic effect of topical administration of SN50, an inhibitor of nuclear factor-kappaB, in treatment of corneal alkali burns in mice.2005

Author(s)

Journal Title

Description

OHNISHI Yoshitaka 大西克尚