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YAMAGUCHI Tadatoshi  山口 忠敏

ORCIDConnect your ORCID iD *help
Researcher Number 80037598
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2011 – 2013: 崇城大学, 薬学部, 教授
2003 – 2004: 宮崎大学, 医学部, 助教授
1996 – 2001: 宮崎医科大学, 医学部, 助教授
1988 – 1991: Dept. of Hygiene, Miyazaki Medical College. Associate Professor, 医学部, 助教授
1986 – 1987: 宮崎医科大学, 講師
1986: 宮崎医科大学, 医学部, 講師
Review Section/Research Field
Principal Investigator
Hygiene / Neurology / Biological pharmacy
Except Principal Investigator
Hygiene / 広領域 / Environmental pharmacy
Keywords
Principal Investigator
dihydropyrazine / radical / PC12 / apoptosis / cultured cell / diabetes / dihydrodiazepine / DNA strand breakage / TDP Kinase / D-glucosamine … More / carbon-centered radical / DNA strand-breakage / Copper(II) / Schwann cell / Superoxide dismutase / 家族性筋萎縮性側索硬化症 / 増殖抑制蛋白 / 増殖関連蛋白 / 神経成長因子 / 交感神経細胞 / ジヒドロピラジン / シュワン細胞 / copper(II) / Schwann / Copper (II) / schwann cell / carbon-centered radical diabetes / tetra azadecalin / carbonーcentered radical / DNA Strand-breakage / Diabetes / carbom-centered radical / DNA strand-breaKage / dihydropyrazime / carbon-centeral radical / Human erythrocytes / Thiamin diphosphate / Thiamin triphosphate / Freezing-thawing treatment / Duchenne type muscular Dystrophy / Protein-bound TDP / TDP-binding protein / protein-binding TDP / TDP-bound protein / TDPkinase / チアミンミリン酸 / チアミンシリン酸 / チアミン / SH阻害剤 / 金属キレ-ト剤 / 筋ジストロフィ-症 / チアミン三燐酸 / チアミン二燐酸 / TDP kinase / ヒト赤血球 / チアミン二リン酸 / チアミン三リン酸 / 凍結ー融解処理 / Duchenne型筋ジストロフィ- / proteinーbound TDP / TDPーbinding protein / cupric ion / plasmid pBR322 / DNA-strand scission / DNA strand-scission … More
Except Principal Investigator
genetic diagnosis / Genetic disease / Duchenne muscular dystrophy / 白血球DNA / サザンブロットハイブリダイゼイション / RFLP / 遺伝子診断制限酵素断片長多型 / PFG / DMD / パルスフィールドゲル電気泳動 / 遺伝性筋肉疾患 / サザンブロット・ハイブリッド法 / 遺伝子診断 / 遺伝性疾患 / デュシェンヌ型筋ジストロフィー症 / DNA damage / D-glucosamine / Aminosugars / 3ーアミノー3ーデオキシアロース / Dーグルコサミン / DNA切断反応 / DNA / プラスミド / pBR322 / マキサム・ギルバート法 / 活性酸素 / DNA切断 / pBR322プラスミド / D-グルコサミン / アミノ糖 / 遺伝子障害 / 糖化反応中間体 / グルタチオンバランス / 細胞障害性 / ジヒドロピラジン類 / HepG2 細胞 / 細胞障害 / 糖尿病 / 酸化的ストレス / 毒性 / 糖化反応 / ジヒドロピラジン Less
  • Research Projects

    (7 results)
  • Research Products

    (3 results)
  • Co-Researchers

    (15 People)
  •  The involvement of dihydropyrazine-induced gene damage in diabetic complication

    • Principal Investigator
      ISHIDA TAKUMI
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Environmental pharmacy
    • Research Institution
      Sojo University
  •  The analysis of onset of familial amyotrophic lateral sclerosis(FALS) with His46Arg point mutationPrincipal Investigator

    • Principal Investigator
      YAMAGUCHI Tadatoshi, 大井 長和
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      University of Miyazaki
      宮崎医科大学
  •  Basic research in the connection of the cause of development of symptoms of diabetes and its complicationPrincipal Investigator

    • Principal Investigator
      YAMAGUCHI Tadatoshi
    • Project Period (FY)
      1998 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hygiene
    • Research Institution
      Miyazaki Medical College
  •  Dihydropyrazine体による核酸鎖切断作用Principal Investigator

    • Principal Investigator
      山口 忠敏
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Biological pharmacy
    • Research Institution
      宮崎医科大学
  •  The nutritional attempt to investigate progressive muscular dystrophy with Duchenne type in human.Principal Investigator

    • Principal Investigator
      YAMAGUCHI Tadatoshi
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hygiene
    • Research Institution
      Miyazaki Medical College
  •  Genetic Diagnosis of Muscular Dystrophy

    • Principal Investigator
      FUKAMACHI Seijiro
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hygiene
    • Research Institution
      Dept. of Hygiene, Miyazaki Medical College.
  •  Amino sugars and their related compounds having nucleic acid- scissoring activity.

    • Principal Investigator
      WATANABE kenji
    • Project Period (FY)
      1985 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      広領域
    • Research Institution
      Fukuoka University

All 2012

All Journal Article Presentation

  • [Journal Article] Possible involvement of glutathione balance disruption in dihydropyrazine-induced cytotoxicity on human hepatoma HepG2 cells2012

    • Author(s)
      Takumi Ishida, Shinji Takechi and Tadatoshi Yamaguchi
    • Journal Title

      J. Toxicol. Sci

      Volume: 37 Pages: 1065-1069

    • NAID

      10030876809

    • URL

      https://www.jstage.jst.go.jp/browse/jts/37/5/_contents/-char/ja/

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590160
  • [Journal Article] Possible involvement of glutathione balance disruption in dihydropyrazine-induced cytotoxicity on human hepatoma HepG2 cells.2012

    • Author(s)
      Takumi Ishida, Shinji Takechi, and tadatoshi Yamaguchi
    • Journal Title

      Journal of Toxicological Sciences

      Volume: 37 Pages: 1065-1069

    • NAID

      10030876809

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590160
  • [Presentation] 糖化反応中間体dihydropyrazineによるglutathione balanceへの影響2012

    • Author(s)
      石田卓巳, 山口忠敏, 武知進士
    • Organizer
      フォーラム2012:衛生薬学・環境トキシコロジー
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23590160
  • 1.  WATANABE kenji (40078689)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  HAMADA Minoru (90039529)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  NOMURA Hajime (80253839)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  ISHIDA TAKUMI (10301342)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 5.  TAKECHI Shinji (10222100)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 6.  KASHIGE Nobuhiro (80185751)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  KAKITA Yukari (80194679)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  NAKASHIMA Yukihiko (50164174)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  SUMOTO Kunihiro (00078677)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  MIHASHI Kunihide (60078681)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  FUKAMACHI Seijiro (90117458)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  TAKENAKA Hitoshi (10179658)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  松本 茂信 (70073038)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  大井 長和 (80135615)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  林田 みき枝 (50173050)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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