ONO Toshio 小野俊雄

… Alternative Names

小野俊雄オノトシオ

Less

Researcher Number	80050607
External Links
Affiliation (based on the past Project Information) *help	2012: 長崎大学, 大学院・医歯薬学総合研究科, 研究員 2011: 長崎大学, 大学院・医歯薬学総合研究科, 助教 2009: 長崎大学, 医歯薬学総合研究科, 助教 2006: Graduate School of Biomedical Sciences, Graduate School of Biomedical Sciences, Assistant Professor, 大学院医歯薬学総合研究科, 助手 2002 – 2004: 長崎大学, 大学院・医歯薬学総合研究科, 助手 … More 2002: Graduate School of Biomedical Sciences Instructor, 大学院・医歯薬学総合研究科, 教授 2001: 長崎大学, 歯学部, 助手 1999: Nagasaki University, School nof Dentistry, Instructor, 歯学部, 助手 1993 – 1995: 長崎大学, 歯学部, 助手 1989: 長崎大学, 歯学部, 教務職員 1987: 長崎大学, 歯学部, 教務職員 Less
Review Section/Research Field	Except Principal Investigator Functional basic dentistry / Functional basic dentistry / Biological Sciences / Morphological basic dentistry
Keywords	Except Principal Investigator HSP90 / 分子シャペロン / molecular chaperone / コラーゲン / HtpG / ドメイン構造 / HSP47 / 石灰化 / プロテアーゼ / セリンプロテアーゼ … More / 黄色ブドウ球菌 / ジペプチジルペプチダーゼ / 歯周病 / ストレス / oral bacteria / protease inhibitor / protease / 抗菌活性 / MPI / 自然免疫系 / 口腔細菌 / プロテアーゼインヒビター / stress / periodontitis / P. gingivalis / P.gingivalis / scar / domain structure / collagen / Hsp9Q / ペプチド結合 / 分子シャロペン / 瘢痕 / dimer / oligomer / systemic lupus erythematosus (SLE) / domain / stress protein / アイメフォーム / 骨芽細胞 / 自己抗体 / ダイマー / オリゴマー / 全身性エリテマトーデス / ドメイン / ストレスタンパク質 / Plasma polymerized film repica method / Tendon / Bone / Biomineralization / Helical filament model / Collagen / Calcification / コラーゲン繊維 / プラズマ膜 / 原子間力顕微鏡 / 石灰化機構 / プラズマ重合膜レプリカ法 / 腱 / 骨 / バイオミネラリゼーション / らせんフィラメントモデル / 陽イオン交換ゲル / 石灰化前質 / イオン透過 / プロテオグリカン / 酵素 / ブドウ球菌 / 活性化 / 病原因子 / リコンビナントタンパク質 / プロセシング / コアグラーゼポジティブ / グルタミン酸特異的プロテアーゼ / リコンビナント体 / グルタミン酸特異的 / ETA / DPP11 / DPP7 / 表皮剥脱毒素 / 熱傷様皮膚症候群 / Porphyromonas gingivalis / Staphylococcus aureus / とびひ / ブドウ球菌性熱傷様皮膚症候群 / 自己重合 / クライアント / エピトープ / 蛋白質 / 分子認識 / 生体分子 / HfpG / 構造モデル / 線維形成 / コラ-ゲン Less

Study on the Glu-specific protease superfamily mediating dissociation of cell-cell adhesion
- Principal Investigator
  
  NEMOTO Yuko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Nagasaki University
Therapeutic Establishment for Gingival Hyperplasia and Scar Formation by Use of Collagen-Digestible Proteases
- Principal Investigator
  
  NEMOTO Takayuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Nagasaki University
Analysis of the effects of mucous protease inhibitor on periodontopathic bacteria and their proteases
- Principal Investigator
  
  NEMOTO Yuko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Nagasaki University
  Iwate Medical University
原核生物HSP90分子シャペロンの機能は真核生物と同じか?
- Principal Investigator
  
  根本孝幸
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
原核生物および真核生物HSP90分子シャペロン共通の作用メカニズム
- Principal Investigator
  
  NEMOTO Takayuki
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
FUNCTIONAL ANALYSIS OF HEAT SHOCK PROTEIN HtpG FROM PF gingivalis WHICH CAUSES PERIODONTITIS
- Principal Investigator
  
  KOBAYAKAWA Takeshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Nagasaki University
Collagen processing and molecular chaperones : molecular anatomy based on the domain structures
- Principal Investigator
  
  NEMOTO Takayuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Nagasaki University
Domain structure, expressional regulation and autoimmunity of HSP90
- Principal Investigator
  
  NEMOTO Takayuki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Nagasaki University
  Iwate Medical University
Molecular level studies on biomineralization
- Principal Investigator
  
  KATSURA Nobuhiko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Nagasaki University
コラ-ゲンの階層的線維形成因子の研究
- Principal Investigator
  
  KATSURA Nobuhiko
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Institution
  Nagasaki University
石灰化前質のカルシウムおよびリン酸イオンの透過性に関する基礎的研究
- Principal Investigator
  
  桂暢彦
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Nagasaki University

All 2013 2012 2011 2010 2009 2005

All Journal Article Presentation

[Journal Article] Discrimination based on Gly and Arg/Ser at Position 673 between Dipeptidyl-peptidase (DPP) 7 and DPP11, Widely Distributed DPPs in Pathogenic and Environmental Gram-Negative Bacteria2013
- Author(s)
  Rouf, S.M.A., Ohara-Nemoto, Y., Hoshino, T., Fujiwara, T., Ono, T., Nemoto, T.K.
- Journal Title
  
  Biochimie
  
  Volume: 95 Issue: 4 Pages: 824-831
- DOI
  10.1016/j.biochi.2012.11.019
- NAID
  120006985514
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592070, KAKENHI-PROJECT-24592809
[Journal Article] Asp-and Glu-specific novel dipeptidyl peptidase 11 of Porphyromonas gingivalis that ensures utilization of proteinaceous energy sources2011
- Author(s)
  Ohara-Nemoto Y, Shimoyama Y, Kimura Y, Kon A, Haraga H, Ono T, and Nemoto TK
- Journal Title
  
  J. Biol. Chem
  
  Volume: 286 Pages: 38115-38127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592367
[Journal Article] Amino acid residues modulating the activities of staphylococcal glutamyl endopeptidases.2010
- Author(s)
  Ono Toshio
- Journal Title
  
  Biol.Chem.
  
  Volume: 391 Pages: 1221-1262
- NAID
  120006984895
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592367
[Journal Article] Amino acid residues modulating the activities of staphylococcal glutamyl endopeptidases.2010
- Author(s)
  Ono Toshio
- Journal Title
  
  Biological Chemistry
  
  Volume: 391 Pages: 1221-1262
- NAID
  120006984895
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592070
[Journal Article] Amino acid residues modulating the activities of staphylococcal glutamyl endopeptidases2010
- Author(s)
  Ono, T., Ohara-Nemoto, Y., Shimoyama, Y., Okawara, H., Kobayakawa, T., Baba, T., Kimura, S., Nemoto, T.K.
- Journal Title
  
  Biol Chem
  
  Volume: 391 Issue: 10 Pages: 1221-1232
- DOI
  10.1515/bc.2010.116
- NAID
  120006984895
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592070
[Journal Article] Amino acid residues modulating the activities of staphylococcal glutamyl endopeptidases2010
- Author(s)
  Ono T, Ohara-Nemoto Y, Shimoyama Y, Okawara H, Kobayakawa T, Baba TT, Kimura S, and Nemoto TK
- Journal Title
  
  Biol. Chem
  
  Volume: 391 Pages: 1221-1232
- NAID
  120006984895
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592367
[Journal Article] Determination of three amino acids that caused the alteration of proteolytic activities of staphylococcal glutamyl endopeptidases.2009
- Author(s)
  Nemoto TK, Ono T, Shimoyama Y, Kimura S, Ohara-Nemoto Y
- Journal Title
  
  Biol.Chem. 390
  
  Pages: 277-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592367
[Journal Article] Determination of three amino acids that caused the alteration of proteolytic activities of staphylococcal glutamyl endopeptidases2009
- Author(s)
  Nemoto TK, Ono T, Shimoyama Y, Kimura S, Ohara-Nemoto Y
- Journal Title
  
  Biol Chem
  
  Volume: 390(3) Pages: 277-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592367
[Journal Article] Two forms of apatite deposited during mineralization of the hen tendon2005
- Author(s)
  Ono T., Nernoto T.K.
- Journal Title
  
  Matrix Biology (in press)
- Data Source
  KAKENHI-PROJECT-15032243
[Presentation] Substrate specificity of four dipeptidyl peptidases from Porphyromonas gingivalis and the dipeptide repertoire produced by the bacterium2012
- Author(s)
  柳瀬絵美，ラオフアブドユー，小野俊夫，根本優子，根本孝幸
- Organizer
  第54回歯科基礎医学学術大会
- Place of Presentation
  郡山市
- Data Source
  KAKENHI-PROJECT-22592070
[Presentation] Expression and Characterization of Dipeptidyl- Peptidases of Porphyromonas gingivalis2012
- Author(s)
  Rouf, S.M.A., Ohara-Nemoto, Y, Yanase, A., Ono, T., Nemoto, T.K
- Organizer
  1st International Conference on Porphyromonas gingivalis and Related Bacterial Species
- Place of Presentation
  Nagasaki, Japan
- Year and Date
  2012-08-27
- Data Source
  KAKENHI-PROJECT-22592070
[Presentation] DPP 7と新規Asp/ Glu特異的DPP11を含むS46ペプチダーゼファミリーの再分類2012
- Author(s)
  シャークラオフ, 根本優子, 小野俊雄, 星野倫範, 藤原卓, 根本孝幸
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-21592367
[Presentation] Porphyromonas属菌が産生するAsp/Glu特異的新規ジペプチジルペプチダーゼ(DPP)11の同定と基質特異性の検討2012
- Author(s)
  根本孝幸, SMAラオフ, 小野俊雄,下山佑,木村重信,根本優子
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎市
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-22592070
[Presentation] Expression and Characterization of Dipeptidyl-Peptidases of Porphyromonas gingivalis2012
- Author(s)
  Rouf, Shakh M. A., Ohara-Nemoto, Y., Yanase, A., Ono T., and Nemoto, T. K.
- Organizer
  1st International Conference on Porphyromonas gingivalis and Related Bacterial Species
- Place of Presentation
  Nagasaki, Japan
- Data Source
  KAKENHI-PROJECT-22592070
[Presentation] Classification and essential amino acid residues of the dipeptidyl peptidase 7/11 family in the Cytophaga- Flavobacterium-Bacteroides group2012
- Author(s)
  Ohara-Nemoto, Y., Rouf, S.M.A., Hoshino, T., Fujiwara, T., Shimoyama, Y., Kimura, S., Ono, T., Nemoto, T.K.
- Organizer
  112th General Meeting of ASM
- Place of Presentation
  San Francisco, USA
- Year and Date
  2012-06-18
- Data Source
  KAKENHI-PROJECT-22592070
[Presentation] Classification and essential amino acid residues of the dipeptidyl peptidase 7/11 family in the Cytophaga-Flavobacterium-Bacteroides group2012
- Author(s)
  Ohara-Nemoto, Y., Abdur-Rouf, S. M., Hoshino, T., Fujiwara, T., Shimoyama, Y., Kimura, S., Ono, T., and Nemoto, T. K.
- Organizer
  112th General Meeting of American Society for Microbiology
- Place of Presentation
  San Francisco, CA, USA
- Data Source
  KAKENHI-PROJECT-22592070
[Presentation] Classification of the S46 (DPP7/DPP11) family members and identification of a subtype of DPP112012
- Author(s)
  根本孝幸，ラオフアブドユー，小野俊夫，下山佑，木村重信，根本優子
- Organizer
  第54回歯科基礎医学学術大会
- Place of Presentation
  郡山市
- Data Source
  KAKENHI-PROJECT-22592070
[Presentation] Porphyromonas属新規Asp/ Glu特異的ジペプチジルペプチダーゼの同定2012
- Author(s)
  根本孝幸, シャークラオフ, 小野俊雄, 下山佑, 木村重信, 根本優子
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-21592367
[Presentation] Porphyromonas gingivalis DPP11の酵素活性とAsp/ Glu特異性を規定するArg^<670>2011
- Author(s)
  根本孝幸, 小野俊雄, 下山佑, 木村重信, 根本優子
- Organizer
  第53回歯科基礎医学学術大会
- Place of Presentation
  岐阜
- Year and Date
  2011-10-01
- Data Source
  KAKENHI-PROJECT-21592367
[Presentation] Biochemical characterization of DPP11 : Importance of arginine670 for the enzymatic activity specific for the P1-position acidic residue2011
- Author(s)
  Nemoto TK, Ono T, Rouf SMA, Shimoyama Y, Kimura S, Tetsuo F, Ohara-Nemoto Y
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館京都
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-21592367
[Presentation] Porphyromonas gingivalis DPP11の酵素活性とAsp/Glu特異性を規定するArg6702011
- Author(s)
  根本孝幸, 小野俊雄, 下山佑, 木村重信, 根本優子
- Organizer
  第53回歯科基礎医学学術大会
- Place of Presentation
  長良川国際会議場岐阜
- Year and Date
  2011-10-01
- Data Source
  KAKENHI-PROJECT-21592367
[Presentation] Auto-catalytic propeptide processing facilitates the final hetero-catalytic maturation of glutamyl endopeptidase GluV82011
- Author(s)
  Ohara-Nemoto Y, Rouf SMA, Shimoyama Y, Kimura S, Ono T, Nemoto TK
- Organizer
  111th General Meeting of American Society for Microbiology
- Place of Presentation
  New Orleans, Louisiana, USA
- Year and Date
  2011-05-24
- Data Source
  KAKENHI-PROJECT-21592367
[Presentation] Auto-catalytic propeptide processing facilitates the final hetero-catalytic maturation of glutamyl endopeptidase GluV82011
- Author(s)
  Ohara-Nemoto, Y, Rouf, S.M.A, Shimoyama, Y., Kimura, S., Ono, T., Nemoto, T.K.
- Organizer
  111th General Meeting of AmericanSociety for Microbiology
- Place of Presentation
  New Orleans, USA
- Year and Date
  2011-05-24
- Data Source
  KAKENHI-PROJECT-22592070
[Presentation] Autocatalytic propeptide processing facilitates the final hetero-catalytic maturation of glutamyl endopeptidase GluV82011
- Author(s)
  Ohara-Nemoto Y, Rouf SMA, Shimoyama Y, Kimura S, Ono T, and Nemoto TK
- Organizer
  111th General Meeting of American Society for Microbiology
- Place of Presentation
  New Orleans, Louisiana, USA
- Year and Date
  2011-05-24
- Data Source
  KAKENHI-PROJECT-21592367
[Presentation] Biochemical characterization of DPP11 : Importance of arginine^<670> for the enzymatic activity specific for the P1-position acidic residue.2011
- Author(s)
  Nemoto TK, Ono T, Rouf SMA, Shimoyama Y, Kimura S, Tetsuo F, and Ohara-Nemoto Y
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-21592367
[Presentation] Autocatalytic processing of prosequence prior to maturation of Staphylococcal glutamyl endopeptidases2010
- Author(s)
  Shakh M. A. Rouf, 根本優子, 小野俊雄, 下山佑, 木村重信, 根本孝幸
- Organizer
  第33回日本分子生物学会年会第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21592367
[Presentation] 新規V8プロテアーゼファミリー遺伝子のクローニングと8プロテアーゼ活性に重要なN末バリンと185-195領域の同定2010
- Author(s)
  根本孝幸, 小野俊雄, 下山佑, 木村重信, 大河原久実, 根本優子
- Organizer
  第52回歯科基礎医学学術大会
- Place of Presentation
  松戸
- Data Source
  KAKENHI-PROJECT-21592367
[Presentation] Staphylococcus属Glu-プロテアーゼの発現と酵素活性を決定する3アミノ酸の同定.2009
- Author(s)
  根本孝幸, 小野俊雄, 根本優子
- Organizer
  第51回歯科基礎医学学術大会
- Place of Presentation
  新潟
- Year and Date
  2009-09-11
- Data Source
  KAKENHI-PROJECT-21592367
[Presentation] Staphylococcus属Glu-プロテアーゼの発現と酵素活性を決定する3アミノ酸の同定2009
- Author(s)
  根本孝幸, 小野俊雄, 根本優子
- Organizer
  第51回歯科基礎医学学術大会
- Place of Presentation
  第51回歯科基礎医学学術大会
- Year and Date
  2009-09-11
- Data Source
  KAKENHI-PROJECT-21592367
[Presentation] Three amino acid residues define the proteolytic activities of Staphylococcal Glu-specific proteases2009
- Author(s)
  Ohara-Nemoto Y, Ono T, Shimoyama Y, 6 Kimura S, Nemoto TK
- Organizer
  109th General Meeting of American Society for Microbiology
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-21592367

1. KOBAYAKAWA Takeshi (10153587)

# of Collaborated Projects: 9 results

# of Collaborated Products: 2 results
2. NEMOTO Takayuki (90164665)

# of Collaborated Projects: 7 results

# of Collaborated Products: 27 results
3. BABA Tomomi (60189727)

# of Collaborated Projects: 7 results

# of Collaborated Products: 2 results
4. TANAKA Kiichiro (50001954)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. KATSURA Nobuhiko (30013840)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. NAKAYAMA Koji (80150473)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. NEMOTO Yuko (10164667)

# of Collaborated Projects: 3 results

# of Collaborated Products: 27 results
8. KIMURA Shigenobu (10177917)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
9. SHIMOYAMA Yu (90453331)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
10. 田中理 (80207076)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 宮川勇 (50136165)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 永井雅純 (00217960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ONO Toshio 小野 俊雄

小野 俊雄 オノ トシオ

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Discrimination based on Gly and Arg/Ser at Position 673 between Dipeptidyl-peptidase (DPP) 7 and DPP11, Widely Distributed DPPs in Pathogenic and Environmental Gram-Negative Bacteria2013

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Asp-and Glu-specific novel dipeptidyl peptidase 11 of Porphyromonas gingivalis that ensures utilization of proteinaceous energy sources2011

Author(s)

Journal Title

Data Source

[Journal Article] Amino acid residues modulating the activities of staphylococcal glutamyl endopeptidases.2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Amino acid residues modulating the activities of staphylococcal glutamyl endopeptidases.2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Amino acid residues modulating the activities of staphylococcal glutamyl endopeptidases2010

ONO Toshio 小野俊雄

小野俊雄オノトシオ