INOUE Hideo 井上英夫

… Alternative Names

HIDEO Inoue 井上英夫

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Researcher Number	80088856
Other IDs
Affiliation (based on the past Project Information) *help	2008: Osaka City University, 大学院工学研究科, 教授 2006 – 2008: 大阪市立大学, 大学院・工学研究科, 教授 1999: Osaka City University, Faculty of Engineering, department of Bioapplied Chemistry, 工学部, 教授 1998: 北海道大学, 大学院薬学研究科, 助教授 1990 – 1997: Hokkaido University, Faculty of Pharmaceutical Sciences, Associate Professor, 薬学部, 助教授 1988 – 1989: Faculty of Pharmaceutical Sciences, Hokkaido University, 薬学部, 助手 1986: Faculty of Pharmaceutical Sciences, Instructor, 薬学部, 助手
Review Section/Research Field	Principal Investigator Chemical pharmacy / 医薬分子機能学 / Drug development chemistry Except Principal Investigator Biological pharmacy / Chemical pharmacy / 医薬分子機能学
Keywords	Principal Investigator 過マンガン酸カリウム / 8-オキソグアニン / reaction mechanism / neighboring base damage / KMnOィイD24ィエD2 oxidation / 8-oxoadenine / 8-oxoguanine / DNAs containing damaged bases / 損傷塩基近傍の塩基損傷 / 5-ヒドロキシシトシン … More / 5-ヒドロキシウラシル / 酸化損傷塩基の酸化 / DNA損傷 / KMnO_4酸化 / 反応機構 / 周辺塩基の損傷 / KMnO4酸化 / 8-オキソアデニン / 塩基損傷DNA基質 / ELISA / Dewar isomer / (6-4) photo product / thymine dimer / single-chain antibody / monoclonal antibody / UV-damaged DNA / Dewar型変性体 / ELISA法 / Dewar型異性体 / (6-4)光産物 / チミンダイマー / 一本鎖抗体 / モノクローナル抗体 / 紫外線損傷DNA / Substrate recognition site / Lysyl endopeptidase / Crosslinking / Photoactive oligodeoxynucleotide / Photoaffinity labeling / RNA-DNA hybrid / E. coli RNase H / 大腸菌RNaseH / RNA・DNAハイブリド / 大腸菌RNase H / 基質認識部位 / リシルエンドペプチダ-ゼ / クロスリンキング / 反応性デオキシオリゴヌクレオチド / 光親和性標識 / RNA・DNA ハイブリド / 大陽菌 RNaseH / 塩基配列特異的 / 金属錯触媒 / 塩基配列特異白 / 人工RNA分解酵素 / 分子設計 / 金属錯体触媒 / オリゴヌクレオチド誘導体 / 塩基配列特異的切断 / アンチセンス核酸医薬 / 人工RNA 分解酵素 / 酸化損傷 / 水酸ラジカル / X線照射 / DNA … More Except Principal Investigator チミンダイマー / 合成遺伝子 / 紫外線損傷DNA / T4エンドヌクレアーゼV / T4エンドヌクレア-ゼV / RNA / RNA切断 / ras遺伝子 / メチル化保護法 / ホスホロチオエート / 酵素ー基質複合体 / チミンダイマ- / Chimeric oligonucleotide / 2'-O-Methyloligoribonucleotide / RNA・modified DNA hybrid / RNase H / Sequence-specific cleavage of RNA / Site-specific cleavage of RNA / )f> / 大腸菌tRNA<Met( / 2′-O-メチルオリゴリボヌクレオチド / 大腸菌tRNA<met(＼)f> / キメラオリゴヌクレオチド / 2'-0-メチルオリゴリボヌクレオチド / RNA・修飾DNAハイブリド / 大腸菌RNaseH / RNAの塩基配列特異的切断 / RNAの位置特異的切断 / GDP binding activity / Monoclonal antibodies / Synthetic gene / c-Ha-ras gene / GDP結合蛋白質 / P21 / GTPase活性 / GDP結合活性 / モノクローナル抗体 / C-Ha-ras遺伝子 / Ribonuclease / Nucleoside conformation / Cyclonucleosides / Stereochemistry / Nucleotides / Nucleosides / アデノシンデアミナーゼ / リボヌクレアーゼ / ヌクレオシドのコンフォーメーション / シクロヌクレオシド / ヌクレオシドの立体化学 / ヌクレオチド / ヌクレオシド / Flexible Linker / Single Chain Antibody / PCR Cloning / Thymine Dimer / UV-damaged DNA / フレキシブルリンカー / シングル鎖抗体 / PCRクローニング / NIH3T3 cell / cell transformation / ras gene / Bio-catalysis / RNA enzyme / トランスフォ-メ-ション / NIH3T3細胞 / N1H3T3細胞 / 細胞癌化 / 生体触媒 / RNA酵素 / NMR spectrum / CD spectrum / structure analysis / kinetic parameter / synthetic oligonucleotide / self-cleavage reaction / hammerhead-type ribozyme / リボザイム / オリゴリボヌクレオチド / NMRスペクトル / CDスペクトル / 構造解析 / 酵素活性 / 化学合成オリゴヌクレオチド / 自己切断反応 / ハンマ-ヘッド型リボザイム / 大腸菌トリプトファンプロモーター / T4エンドヌクレアーゼ【V】 / 1本鎖抗体 / バイオセンサー / ファージディスプレイシステム / オリゴヌクレチオド / (6-4)光産物 / オリゴヌクレオチド / メチルホスホネート / 2′-O-メチルRNA-DNA結合体 / 修飾オリゴヌクレオチド / RNaseH / アンチセンスオリゴヌクレオチド / N1H3T3 / DNA修復 / 損傷DNA / 酵素一基質複合体 / フィルターバインディングアッセイ / 2'ーフルオロチミジン / フィルタ-バインディングアッセイ / アベ-シックDNA / DNAエンドヌクレア-ゼ / DNAグリコシダ-ゼ / ホスホロチオエ-ト / ホスホロジチオエ-ト / リン酸ジエステル / オリゴデオキシリボヌクレオチド / DNA切断酵素 / DNA修復酵素 / チミンフォトダイマ- Less

Development of highly active artificial ribonucleases as nucleic acid drugsPrincipal Investigator
- Principal Investigator
  
  INOUE Hideo
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Osaka City University
Studies of neighboring base damage induced by oxidation of synthetic DNAs containing oxidatively damaged basesPrincipal Investigator
- Principal Investigator
  
  INOUE Hideo
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka City University
  Hokkaido University
紫外線損傷塩基を含む化学合成オリゴヌクレオチドを用いたDNA修復機構の研究
- Principal Investigator
  
  森岡弘志
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
DNA中の8-オキソグアニンの酸化による周辺残基の変異Principal Investigator
- Principal Investigator
  
  井上英夫
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
Recognition of DNA by thymine dimers specific antibodiesPrincipal Investigator
- Principal Investigator
  
  INOUE Hideo, 大塚栄子
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  医薬分子機能学
- Research Institution
  Hokkaido University
修飾オリゴヌクレオチドを用いた紫外線損傷DNA修復機構の解析
- Principal Investigator
  
  森岡弘志
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
紫外線誘発DNA損傷による発癌遺伝子活性化に関する研究-化学合成オリゴヌクレオチドを用いた部位特異的導入法によるアプローチ
- Principal Investigator
  
  大塚栄子
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hokkaido University
紫外線損傷塩基を含む化学合成オリゴヌクレオチドと修復酵素との相互作用の解析
- Principal Investigator
  
  森岡弘志
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
RNaseH依存型アンチセンス修飾オリゴヌクレオチドの設計と合成
- Principal Investigator
  
  池原森男
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo University of Science
Photodamage repair of DNA by anti thymine dimer antibody
- Principal Investigator
  
  OHTSUKA Eiko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  HOKKAIDO UNIVERSITY
修飾オリゴヌクレオチドを用いたT4エンドヌクレアーゼVの基質認識機構の解析
- Principal Investigator
  
  森岡弘志
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
チミンダイマ-除去修復機構の合成DNAによる解析
- Principal Investigator
  
  大塚栄子
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hokkaido University
修飾オリゴヌクレオチドを用いたT4エンドヌクレア-ゼVと基質の相互作用の解析
- Principal Investigator
  
  森岡弘志
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
Antisense Activities of Ribozymes in in vivo
- Principal Investigator
  
  OHTSUKA Eiko
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Faculty of Pharmaceutical Sciences Hokkaido University
チミンダイマ-除去修復機構の合成遺伝子による解析
- Principal Investigator
  
  OHTSUKA Eiko
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hokkaido University
T4エンドヌクレア-ゼVの基質認識機構の解析
- Principal Investigator
  
  岩井成憲
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
Elucidation of the Mechanism for the Self-Cleavage Rection of RNA Using Chemically-Synthesized Oligonucleotides
- Principal Investigator
  
  OHTSUKA Eiko
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
Synthesis and Use of Modified Oligonucleotides for the Study on a Substrate Recognition Site of RNase HPrincipal Investigator
- Principal Investigator
  
  INOUE Hideo
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Hokkaido University
Development of site-specific RNA cleaving method using modified DNA splints-RNase H system
- Principal Investigator
  
  OHTSUKA Eiko
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
合成遺伝子を用いるDNA修復酵素の機能の研究
- Principal Investigator
  
  大塚栄子
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hokkaido University
Development of cancer diagnosis using monoclonal antibodies specific for ras gene products
- Principal Investigator
  
  OHTSUKA Eiko
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
Stereochemical Studies of Nucleosides and Nucleotides
- Principal Investigator
  
  TOHRU Ueda
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Hokkaido University

All 2008 2007 2006

All Journal Article Presentation

[Journal Article] Structure-activity relationship of an antisense oligonucleotide-two Cu(II)complex conjugate as an artificial ribonuclease2008
- Author(s)
  Daiki Mukoguchi, Satoshi Sakamoto, Hiroshi Takayama, Masaya Kitamura and Hideo Inoue
- Journal Title
  
  Nucleic Acids Symp. Ser. No. 52
  
  Pages: 377-378
- Data Source
  KAKENHI-PROJECT-18590102
[Journal Article] Development of Site-specific Artificial Ribonucleases2007
- Author(s)
  Hiroshi Takayama, Satoshi Sakamoto, Masaya Kitamura and Hideo Inoue
- Journal Title
  
  Nucleic Acids Symp. Ser. No. 51
  
  Pages: 203-204
- Data Source
  KAKENHI-PROJECT-18590102
[Journal Article] Synthesis and ribonuclease activity of oligonucleotides with N3-terpyridine-Cu(II)-linked thymine residues2006
- Author(s)
  Kazuhiro Hara, Masaya Kitamura and Hideo Inoue
- Journal Title
  
  Nucleic Acids Symp. Ser. No. 50
  
  Pages: 71-72
- Data Source
  KAKENHI-PROJECT-18590102
[Presentation] 人工リボヌクレアーゼとしてのアンチセンスオリゴヌクレオチド-二つのCu(II)錯体コンジュゲートの構造-活性相関2008
- Author(s)
  向口大喜、阪本聡、高山弘、北村昌也、井上英夫(発表者)
- Organizer
  第18回 International Roundtable on Nucleosides, Nucleotides and Nucleic Acids、第35回 International Symposium on Nucleic Acids Chemistry 合同シンポジウム
- Place of Presentation
  京都大学
- Year and Date
  2008-09-11
- Data Source
  KAKENHI-PROJECT-18590102
[Presentation] 金属錯体結合オリゴヌクレオチド系RNA切断剤の構造活性相関2008
- Author(s)
  井上英夫
- Organizer
  Joint Symposium of the 18th Inter- national Roundtable on Nucleosides, Nucleotdes and Nucleic Acids and the 35th International Symposium on Nucle-ic Acids Chemistry
- Place of Presentation
  京都大学百周年時計台記念館
- Year and Date
  2008-09-10
- Data Source
  KAKENHI-PROJECT-18590102
[Presentation] 位置特異的人工リボヌクレアーゼの開発2007
- Author(s)
  高山弘(発表者)、阪本聡、北村昌也、井上英夫
- Organizer
  第5 回International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  東京大学
- Year and Date
  2007-11-21
- Data Source
  KAKENHI-PROJECT-18590102
[Presentation] N3位ターピリジン・Cu(II)錯体結合チミジンを含むオリゴヌクレオチドの合成とリボヌクレアーゼ活性2006
- Author(s)
  原和宏、北村昌也、井上英夫(発表者)
- Organizer
  第33回 Symposium on Nucleic Acids Chemistry
- Place of Presentation
  大阪大学
- Year and Date
  2006-11-21
- Data Source
  KAKENHI-PROJECT-18590102
[Presentation] アンチセンス化合物としての人工リボヌクレアーゼの開発2006
- Author(s)
  高山弘(発表者)、阪本聡、北村昌也、井上英夫
- Organizer
  第16 回アンチセンスシンポジウム
- Place of Presentation
  京都国際会議場
- Year and Date
  2006-11-27
- Data Source
  KAKENHI-PROJECT-18590102

1. OHTSUKA Eiko (80028836)

# of Collaborated Projects: 16 results

# of Collaborated Products: 0 results
2. IWAI Shigenori (10168544)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
3. MORIOKA Hiroshi (20230097)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
4. KAMIYA Hiroyuki (10204629)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
5. KAZUNOBU Miura (70001980)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. NIKAIDO Osamu (60019669)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. MATSUNAGA Tsukasa (60192340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KOMATSU Yasuo (30271670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TOHRU Ueda (00001032)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. AKIRA Matsuda (90157313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. AKIHIKO Nomura (10001041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KIYOMI Tsuchida (60088862)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 池原森男 (10028821)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 実吉峯郎 (20002339)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. STEWART Jon D.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. BENKOVIC Stephen J.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

INOUE Hideo 井上 英夫

HIDEO Inoue 井上 英夫

Research Projects

Research Products

Co-Researchers

Development of highly active artificial ribonucleases as nucleic acid drugsPrincipal Investigator

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Studies of neighboring base damage induced by oxidation of synthetic DNAs containing oxidatively damaged basesPrincipal Investigator

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DNA中の8-オキソグアニンの酸化による周辺残基の変異Principal Investigator

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Recognition of DNA by thymine dimers specific antibodiesPrincipal Investigator

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INOUE Hideo 井上英夫

HIDEO Inoue 井上英夫