TAKAHASHI Hakuo 高橋伯夫

Researcher Number	80094431
External Links
Affiliation (based on the past Project Information) *help	1993 – 2011: 関西医科大学, 医学部, 教授 1990 – 1991: 京都府立医科大学, 医学部, 助教授 1987: Second Department of Internal Medicine, Kyoto Prefectural University of Medicine, 医学部, 助手 1986: 京府医大, 医学部, 助手
Review Section/Research Field	Principal Investigator Laboratory medicine / Circulatory organs internal medicine / 内分泌・代謝学 / Laboratory medicine Except Principal Investigator Laboratory medicine / Laboratory medicine / Anesthesiology/Resuscitation studies
Keywords	Principal Investigator 高血圧 / 内因性ジギタリス / ウアバイン / 食塩 / 培養細胞 / 視床下部 / 副腎 / ELISA / 構造解析 / ENDOGENOUS DIGITALIS … More / 神経系 / OUABAIN / CENTRAL NERVOUS SYSTEM / HYPERTENSION / SODIUM / 内因性ジギタリス様物質 / ジギタリス / 電解質代謝 / angiotensin II / sodium salt / hypothalamus / digitalis-like substance / Hypertension / 交感神経活動 / アンジオテンシン11 / 食塩(ナトリウム) / mass spectrometry / liquid chromatography / sodium loading / telocinobufagin / marinobufagenin / endogenous digitalis / 液体クロマトグララフィー / 慢性腎不全 / 質量分析 / 液体クロマトグラフィー / 食塩負荷 / テロシノブファギン / マリノブファゲニン / MASS SPECTROMETRY / PROGESTERONE / NEURONAL TISSUE / ADRENAL MEDULLA / CULTURED CELLS / プロゲステロン / 副腎髄質 / CELL CULTURE / DIGITALIS BINDING PROTEIN / BLOOD PRESSURE / SODIUM BALANCE / 細胞培養 / ウアバイン結合タンパク / 内因性ウアバイン / 内因性ジキタリス / 成長因子 / ADRENAL / HYPOTHALAMUS / DIGITALIS GYLCOSIDE / IMMUNOHISTOCHEMISTRY / INSULIN RESISTANCE / ENDOGENOUS DIGITALIS-LIKE SUBSTANCE / 脈管作動性物質 / ジギタリス様物質 / ナトリウム利尿ホルモン / 免疫組織化学 / 中枢神経系 / インスリン抵抗性 / アンジオテンシンII / ナトリウム塩 / アルドステロン / バイオマーカー / 脳・神経 / 凝固・分子マーカー / ヘリコバクターピロリ / 高感度CRP / 炎症 / 一酸化窒素(NO) / 虚血性心疾患 / 動脈硬化症 / クラミジアニューモニエ … More Except Principal Investigator 内因性ジギタリス / cardenolides / bufadienolide / endogenous digitalis-like factor / マリノブフォトキシン / カルデノライド / 腎臓 / 質量分析 / ブファディエノライド / MS / LC / HPLC / IgA isotype anticardiolipin antibodies / 血清一酸化窒素 / 深部静脈血栓症 / 閉塞性動脈硬化症 / 抗リン脂質抗体症候群 / IgA型抗リン脂質抗体 / cardiotonic steroid / esterase / angiotensin / renin / marinobufotoxin / 腎尿細管 / ショック / 組織カリクレイン / コレステロールエステラーゼ / 強心ステロイド / エステラーゼ / アンギオテンシン / レニン / poisoning analysis / kidney / liquid chromatography / mass spectrometry / telocinobufagin / ブファジエノライド / 副腎髄質 / 副腎皮質 / テロシノブフォトキシン / モノクローナル抗体 / ELISA / 血圧 / マリノブファギン / ブファリン / 内因性ジギタリス様物質 / 薬毒物分析 / 液体クロマトグラフィー / テロシノブファギン / poisoning / N-acetyl-p-benzoquinone imine / N-acetylcysteine / acetaminophen / AKBR / 肝ミトコンドリア / LCMS / Nアセチルベンゾキノンイミン / 中毒 / Nアセチルベンゾキンイミン / Nアセチルシステイン / アセトアミノフェン / Atrial fibrilation / Angina pectoris / Myocardial infarction / Antiphospholipid antibodies syndrome / 血清-酸化窒素 / 血液凝固線溶系検査 / 急性心筋梗塞 / 血漿フィブリノゲン量 / 血小板数 / 心房細動 / 狭心症 / 心筋梗塞 / Thrombosis / Antiphospholipid syndrom (APS) / SLE / Serum nitric oxide / 動脈系血栓症 / 下肢静脈血栓症 / ループスアンチコアグラント / 凝固線溶系検査 / 下垂体 / 臨床検査 / 腎障害 / 視床下部 / アルドステロン / 血管内皮細胞 / 血小板 / 動脈硬化症 / 5HT_2受容体 / セロトニン(5HT) Less

Protective effects of endogenous digitalislike factor on the injury of kidney by aldosterone
- Principal Investigator
  
  KOMIYAMA Yutaka
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kansai Medical University
Studies on the role of endogenous digitalis in electrolytes and blood pressure regulationPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Hakuo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kansai Medical University
Clinical Chemistry of Newly-found Esterase for Endogenous Digitalis-like Factor
- Principal Investigator
  
  KOMIYAMA Yutaka
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kansai Medical University
Clinical Chemistry of Newly-found Endogenous Bufalin Isomer in Saliva
- Principal Investigator
  
  KOMIYAMA Yutaka
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kansai Medical University
Structural analysis of endogenous digitalis and studies on the role of it in electrolytes and blood pressure control. In particular, studies on a novel substance, marinobufagenin with double hydrogen.Principal Investigator
- Principal Investigator
  
  TAKAHASHI Hakuo
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kansai Medical University
Research on the movement of antidotes and toxic metabolites in the patients with acetaminophen poisoning
- Principal Investigator
  
  KIRIDOSHI Masaya
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kansai Medical University
冠動脈疾患の危険因子としての抗クラミジアニューモニエ抗体価の臨床的意義に関する研究-内皮細胞由来血管作動性物質と凝固系分子マーカーからの基礎的検討-Principal Investigator
- Principal Investigator
  
  高橋伯夫
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Kansai Medical University
IDENTIFICATION OF ENDOGENOUS DIGITALIS AND THE ROLE IN WATER-ELETROLYTES BALANCES AND BLOOD PRESSURE REGULATIONPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Hakuo
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Laboratory medicine
- Research Institution
  KANSAI MEDICAL UNIVERSITY
動脈硬化症の病態に占めるセロトニン(5HT)_2受容体の役割の解明
- Principal Investigator
  
  津田信幸
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Kansai Medical University
STUDIES ON IDENTIFICATION OF ENDOGENOUS DIGITALISLIKE FACTOR,AND THE ROLE IN WATER-ELECTROLYTES BALANCE AND BLOOD PRESSURE REGULATIONPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Hakuo
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  KANSAI MEDICAL UNIVERSITY
The Correlation between IgA Isotype Anticardiolipin Antibodies and Thrombotic Events.
- Principal Investigator
  
  EGAWA Hiroshi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kansai Medical University
Measurement of IgA Isotype Anticardiolipin Antibodies and Its Clinical Significance.
- Principal Investigator
  
  EGAWA Hiroshi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kansai Medical University
SODIUM-INDUCED HYPERTENSION AND THE ENDOGENOUS DIGITALISLIKE FACTOR OF THE HYPOTHALAMIC ORIGINPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Hakuo
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  KANSAI MEDICAL UNIVERSITY
FUNDAMENTAL STUDIES ON THE HYPOTHALAMIC DIGITALIS-LIKE SUBSTANCEPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Hakuo
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO PREFECTURAL UNIVERSITY OF MEDICINE
STUDIES ON THE BRAIN MECHANISM OF HYPERTENSION:THE ROLE OF THE HYPOTHALAMIC, ENDOGENOUS DIGITALIS-LIKE SUBSTANCEPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Hakuo
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyoto Prefectural University of Medicine

All 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 Other

All Journal Article Presentation Book

[Book] 内分泌性高血圧診療マニュアル(内因性ジギタリス)2010
- Author(s)
  高橋伯夫(分担執筆)
- Total Pages
  188
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-20590589
[Book] 「早朝高血圧の治療」虚血性心疾患を伴った場合2003
- Author(s)
  高橋伯夫
- Publisher
  総合医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572191
[Journal Article] The central mechanism of hypertension of every cause-Highlights on sodium ion, epithelial sodium channel, renin-angiotensinaldosterone, oxidative stress and endogenous digitalis in the brain-2011
- Author(s)
  Takahashi H, Yoshika M, Komiyama Y, Nishimura M
- Journal Title
  
  Hypertension Research (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590589
[Journal Article] Ca^<2+> Entry Mode of Na^+/Ca^<2+> Exchanger as A New Therapeutic Target for Heart Failure with Preserved Ejection Fraction.2011
- Author(s)
  Kamimura D, Ohtani T, Sakata Y, Mano T, Takeda Y, Tamaki S, Omori Y, Tsukamoto Y, Furutani K, Komiyama Y, Yoshika M, Takahashi H, Matsuda T, Baba A, Umemura S, Miwa T, Komuro I, Yamamoto K
- Journal Title
  
  Eur Heart J. (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590589
[Journal Article] An ouabain-like factor is secreted from immortalized hypothalamic cells, and the release is regulated by aldosterone.2011
- Author(s)
  Yoshika M, Komiyama Y, Takahashi H
- Journal Title
  
  Neurochemistry International (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590589
[Journal Article] 内因性ジギタリス2011
- Author(s)
  吉賀正亨、小宮山豊、高橋伯夫
- Journal Title
  
  検査と技術
  
  Volume: 39 Pages: 561-564
- Data Source
  KAKENHI-PROJECT-21590643
[Journal Article] Isolation of marinobufagenin from the supernatant of cultured PC12 cells2011
- Author(s)
  Yoshika M, Komiyama Y, Takahashi H.
- Journal Title
  
  Clinical and Experimental Pharmacology and Physiology
  
  Volume: 38 Pages: 334-337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590589
[Journal Article] Evidence for a novel digitalis-like factor, telocinobufotoxin, in human plasma.2011
- Author(s)
  Yoshika M, Komiyama Y, Konishi M, Akizawa T, Takahashi H
- Journal Title
  
  Submitted for publication
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590589
[Journal Article] An ouabain-like factor is secreted from immortalized hypothalamic cells in an aldosterone-dependent manner2011
- Author(s)
  Yoshika M, Komiyama Y, Takahashi H, et al
- Journal Title
  
  Neurochem Int
  
  Volume: 59 Pages: 104-108
- Data Source
  KAKENHI-PROJECT-21590643
[Journal Article] Isolation of marinobufotoxin from the supernatant of cultured PC12 cells.2011
- Author(s)
  Yoshika M, Komiyama Y, Takahashi H
- Journal Title
  
  Clin Exp Pharmacol Physiol. 38
  
  Pages: 334-337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590589
[Journal Article] Ca2+entry mode of Na+/Ca2+exchanger as a new therapeutic target for heart failure with preserved ejection fraction2011
- Author(s)
  Kamimura D, Komiyama Y, Yoshika M, Takahashi H, et al
- Journal Title
  
  Eur Heart J Epub
  
  Pages: 1-9
- Data Source
  KAKENHI-PROJECT-21590643
[Journal Article] Isolation of marinobufotoxin from the supernatant of cultured PC12 cells2011
- Author(s)
  Yoshika M, Komiyama Y, Takahashi H, et al
- Journal Title
  
  Clin Exp Pharmacol Physiol
  
  Volume: 38 Pages: 334-337
- Data Source
  KAKENHI-PROJECT-21590643
[Journal Article] The central mechanism underlying hypertension : a review of the roles of sodium ions, epithelial sodium channels, the renin-angiotensin-aldosterone system, oxidative stress and endogenous digitalis in the brain2011
- Author(s)
  Takahashi H, Komiyama Y、Yoshika M, et al
- Journal Title
  
  Hypertens Res
  
  Volume: 34 Pages: 1147-60
- NAID
  10030276766
- Data Source
  KAKENHI-PROJECT-21590643
[Journal Article] 自然発症高血圧ラットにおける内因性ジギタリス様物質、マリノブフォトキシンの動態血圧調節におけるレニン・アンジオテンシン系の関与について2009
- Author(s)
  吉賀正亨、小宮山豊、高橋伯夫
- Journal Title
  
  心臓
  
  Volume: 41 Pages: 401-404
- NAID
  130003376910
- Data Source
  KAKENHI-PROJECT-21590643
[Journal Article] 血管作動性物質-生合成、分泌、生理作用-内因性ジギタリス2009
- Author(s)
  高橋伯夫
- Journal Title
  
  日本臨床増刊号(第4版上) 67巻、Suppl 6号
  
  Pages: 272-277
- Data Source
  KAKENHI-PROJECT-20590589
[Journal Article] 自然発症高血圧ラットにおける内因性ジギタリス様物質、マリノブフォトキシンの動態血圧調節におけるレニン・アンジオテンシン系の関与について2009
- Author(s)
  吉賀正亨, 小宮山豊, 高橋伯夫
- Journal Title
  
  心臓 41
  
  Pages: 401-404
- NAID
  130003376910
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590643
[Journal Article] The present situation and problem of the analytic instruments of clinical toxicology laboratory in hospital. The experience of three laboratory in west Japan.2009
- Author(s)
  Komiyama Y, Hara K, Takahashi H, Tsuda N, Ishibe T, Maruyama K, Hosaka N, Yahiro M, Hideshima R, Manago J
- Journal Title
  
  Chudoku Kenkyu 22
  
  Pages: 12-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Journal Article] 西日本3施設における薬毒物分析機器稼働の現状と課題集団中毒に対する危機管理体制2009
- Author(s)
  小宮山豊, 原克子, 高橋伯夫, 津田紀子, 石部琢也, 丸山克之, 穂坂直美, 八尋美保子, 秀島里沙, 眞名子順一
- Journal Title
  
  中毒研究 22
  
  Pages: 12-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Journal Article] 循環生理活性物質の最新知見血管作動性物質-生合成, 分泌, 生理作用-内因性ジギタリス様物質2009
- Author(s)
  高橋伯夫
- Journal Title
  
  日本臨床 67(増刊6)
  
  Pages: 272-277
- Data Source
  KAKENHI-PROJECT-20590589
[Journal Article] 腎不全とホルモン1. 慢性腎臓病(CKD)の増悪・進展に関与するホルモン内因性ジギタリス様物質.2008
- Author(s)
  高橋伯夫
- Journal Title
  
  ホルモンと臨床 56
  
  Pages: 387-395
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Journal Article] 高血圧性心不全-病態と診断・治療の現状高血圧性心不全と交感神経系2008
- Author(s)
  高橋伯夫
- Journal Title
  
  血圧 15-2
  
  Pages: 140-143
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Journal Article] Hypertension-induced heart failure and sympathetic nerve system2008
- Author(s)
  Hakuo Takahashi
- Journal Title
  
  Ketsuatsu 15
  
  Pages: 140-143
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Journal Article] Endogenous Digitalis Like Factor2008
- Author(s)
  Hakuo Takahashi
- Journal Title
  
  Horumon to Rinsho 56
  
  Pages: 387-395
- NAID
  40016104216
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Journal Article] Novel digitalis-like factor, marinobufotoxin, isolated from cultured Y-1 cells, and its hypertensive effect in rats.2007
- Author(s)
  Yoshika M, Komiyama Y, Konishi M, Akizawa T, Kobayashi T, Date M, Kobatake S, Masuda M, Masaki H, Takahashi H
- Journal Title
  
  Hypertension 49
  
  Pages: 209-214
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590543
[Journal Article] 心不全の病態と臨床検査」新ガイドラインが認める最も優れた検体検査脳性ナトリウム利尿ホルモン、BNP2007
- Author(s)
  高橋伯夫
- Journal Title
  
  臨床病理 55
  
  Pages: 10088-1096
- NAID
  10021234611
- Data Source
  KAKENHI-PROJECT-18590543
[Journal Article] Novel digitalis-like factor, marinobufotoxin, isolated from cultured Y-l cells, and its hypertensive effect in rats.2007
- Author(s)
  Yoshika M, Komiyama Y, Konishi M, Akizawa T, Kobayashi T, Date M, Kobatake S, Masuda M, Masaki H, Takahashi H
- Journal Title
  
  Hypertension 49
  
  Pages: 209-214
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Journal Article] 【腎臓から心血管障害を考える】臨床検査(バイオマーカー)からみた心腎相関2007
- Author(s)
  高橋伯夫
- Journal Title
  
  分子心血管病 8
  
  Pages: 461-468
- Data Source
  KAKENHI-PROJECT-18590543
[Journal Article] 【高血圧最新の研究動向】基礎編血圧調節因子循環生理性物質ジギタリス様物質2006
- Author(s)
  高橋伯夫, 小宮山豊
- Journal Title
  
  日本臨床 64・増刊5
  
  Pages: 177-181
- Data Source
  KAKENHI-PROJECT-18590543
[Journal Article] 特集【体液調節とホルモン】体液調節の基礎 Na利尿ホルモン内因性ジギタリス2006
- Author(s)
  高橋伯夫, 小宮山豊
- Journal Title
  
  ホルモンと臨床 54・5
  
  Pages: 417-423
- Data Source
  KAKENHI-PROJECT-18590543
[Journal Article] A novel endogenous digitalis, telocinobufagin, exhibits elevated plasma levels in patients with terminal renal failure.2005
- Author(s)
  Komiyama Y, Dong XH, Nishimura N, Masaki H, Yoshika M, Masuda M, Takahashi H
- Journal Title
  
  Clin Biochem. 38(1)
  
  Pages: 36-45
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572191
[Journal Article] A novel endogenous digitalis, telocinobufagin, exhibits elevated plasma levels in patients with terminal renal failure.2005
- Author(s)
  Komiyama Y, Dong XH, Nishimura N, Masaki H, Yoshika M, Masuda M, Takahashi H
- Journal Title
  
  Clin Biochem 38
  
  Pages: 36-45
- Data Source
  KAKENHI-PROJECT-16590467
[Journal Article] シリーズ最新医学講座 -臨床現場における薬毒物検査の実際 -第7回「確認分析法(臨床現場におけるGC/MSの活用)」2005
- Author(s)
  原克子, 小宮山豊, 山本透, 高橋伯夫
- Journal Title
  
  臨床検査 49
  
  Pages: 1027-1035
- Data Source
  KAKENHI-PROJECT-16590467
[Journal Article] High-performance liquid chromatographic method with column-switching and post-column reaction for determination of serotonin levels in platelet-poor plasma.2004
- Author(s)
  Hirowatari Y, Hara K, Kamihata H, Iwasaka T, Takahashi H
- Journal Title
  
  Clin Biochem (2004) 37
  
  Pages: 191-197
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572191
[Journal Article] Nanomoler level of ouabain increases intracellular calcium to produce nitric oxide in rat aortic endothelial cells2004
- Author(s)
  Dong, Takahashi et al.
- Journal Title
  
  Clinical and Experimental Pharmacology and Physiology 31
  
  Pages: 276-283
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572191
[Journal Article] The ratio of plasma to Whole-blood serotonin may be a novel marker of atherosclerotic cardiovascular disease.2004
- Author(s)
  Hara K, Hirowatari Y, Yoshika M, Komiyama Y, Tsuka Y, Takahashi H
- Journal Title
  
  J Lab Clin Med (2004)
  
  Pages: 31-37
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572191
[Journal Article] Haemoglobin level influences plasma brain natriuretic peptide concentration.2004
- Author(s)
  Tsuji H, Nishino N, Kimura Y, Yamada K, Nukui M, Yamamoto S, Iwasaka T, Takahashi H.
- Journal Title
  
  Acta Cardiol. 59(5)
  
  Pages: 527-531
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572191
[Journal Article] Haemoglobin level influences plasma brain natriuretic peptide concentration.2004
- Author(s)
  Tsuji, Takahashi, et al.
- Journal Title
  
  Acta Cardiology 59
  
  Pages: 527-531
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572191
[Journal Article] Nanomolar level of ouabain increases intracellular calcium to produce nitric oxide in rat aortic endothelial cells.2004
- Author(s)
  Dong XH, komiyama Y, Nishimura N, Masuda M, Takahashi T
- Journal Title
  
  Clin and Exp Pharmacol and Physiol (2004) 31(5-6)
  
  Pages: 276-283
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572191
[Journal Article] Possible involvement of TNF-a in left ventricular remodeling in hemodialysis patients.2003
- Author(s)
  Nishimura, Takahashi, et al.
- Journal Title
  
  Journal of Nephrology 16
  
  Pages: 641-649
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572191
[Journal Article] Different remodeling against left ventricular overload between diabetic and non-diabetic haemodialysis patients.2003
- Author(s)
  Nishimura, Takahashi, et al.
- Journal Title
  
  Clinical and Experimental Pharmacology and Physiology 30
  
  Pages: 786-792
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572191
[Journal Article] Increase of soluble Fc gamma RIIIa derived from macrophages in plasma from patients with atherosclerosis2002
- Author(s)
  Masuda M, Takahashi H.
- Journal Title
  
  Rinsho Byori. 50(5)
  
  Pages: 502-505
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572191
[Journal Article] 自然発症高血圧ラットにおける内因性ジギタリス様物質, マリノブッォトキシンの動態 -血圧調節におけるレニン-アンジオテンシン系の関与について-
- Author(s)
  吉賀正亨, 小宮山豊, 高橋伯夫
- Journal Title
  
  心臓 (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590543
[Journal Article] An endogenous digitalis-like factor, marinobufotoxin, in spontaneously hypertension rats-involvement of reninangiotensin system in blood pressure regulation-
- Author(s)
  Masamichi Yoshika, Yutaka Komiyama, Hakuo Takahashi
- Journal Title
  
  Shinzo (in printing)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Presentation] 新規内因性ジギタリスであるtelocinobufotoxinの昇圧作用の検討2011
- Author(s)
  吉賀正亨、高橋伯夫、小宮山豊
- Organizer
  第15回日本心血管内分泌代謝学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター、吹田
- Year and Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-21590643
[Presentation] 高血圧発症機序における内因性ジギタリスの臨床検査医学的研究2011
- Author(s)
  吉賀正亨、高橋伯夫、小宮山豊
- Organizer
  第58回日本臨床検査医学会学術集会
- Place of Presentation
  岡山コンベンションセンター、岡山
- Year and Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-21590643
[Presentation] 高血圧発症機序における内因性ジギタリスの臨床検査医学的研究2011
- Author(s)
  吉賀正亨、小宮山豊、高橋伯夫
- Organizer
  第58回日本臨床検査医学会学術集会
- Place of Presentation
  岡山・岡山コンベンションセンター
- Year and Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-21590643
[Presentation] 副腎細胞を用いたアンジオテンシン2受容体拮抗薬の内因性ジギタリス分泌に関する検討2011
- Author(s)
  吉賀正亨、小宮山豊、高橋伯夫
- Organizer
  第51回日本臨床化学会年次学術集会
- Place of Presentation
  札幌・札幌医科大学
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-21590643
[Presentation] 副腎細胞を用いたアンジオテンシン2受容体拮抗薬の内因性ジギタリス分泌に関する検討2011
- Author(s)
  吉賀正亨、高橋伯夫、小宮山豊
- Organizer
  第51回日本臨床化学会年次学術集会
- Place of Presentation
  札幌医科大学、札幌
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-21590643
[Presentation] 新規内因性ジギタリスであるtelocinobufotoxinの昇圧作用の検討2011
- Author(s)
  吉賀正亨、小宮山豊、高橋伯夫
- Organizer
  第15回日本心血管内分泌代謝学会学術集会
- Place of Presentation
  吹田・千里ライフサイエンスセンター
- Year and Date
  2011-11-23
- Data Source
  KAKENHI-PROJECT-21590643
[Presentation] A mineralocorticoid receptor blocker, eplerenone decreases plasma levels of marinobufagenin-like immunoreactivity in rats2010
- Author(s)
  Yoshika M, Komiyama Y, Yokoi T, Masuda M, Masaki H, Takahashi H.
- Organizer
  International Symposium on Cardiovascular Endocrinology and Metabolism
- Place of Presentation
  奈良市, 新公会堂
- Year and Date
  2010-03-31
- Data Source
  KAKENHI-PROJECT-20590589
[Presentation] 中枢神経系における内因性ジギタリス様物質であるouabain分泌に関する検討2010
- Author(s)
  吉賀正亨、小宮山豊、高橋伯夫
- Organizer
  第33回日本高血圧学会総会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2010-10-16
- Data Source
  KAKENHI-PROJECT-20590589
[Presentation] 高血圧発症機序における内因性ジキリタスの臨床検査学的研究2010
- Author(s)
  吉賀正亨,小宮山豊,高橋伯夫
- Organizer
  第57回日本臨床検査医学会学術集会
- Place of Presentation
  京王プラザホテル(東京)
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-20590589
[Presentation] 内因性ジギタリス研究の現状と将来2010
- Author(s)
  高橋伯夫
- Organizer
  第33回日本高血圧学会総会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2010-10-15
- Data Source
  KAKENHI-PROJECT-20590589
[Presentation] 高血圧発症機序における新規内因性ジギタリスの臨床検査学的研究2010
- Author(s)
  吉賀正亨、高橋伯夫、小宮山豊
- Organizer
  第57回日本臨床検査医学会学術集会
- Place of Presentation
  京下プラザホテル、東京
- Year and Date
  2010-09-11
- Data Source
  KAKENHI-PROJECT-21590643
[Presentation] 中枢神経系における内因性ジギタリス様物質であるouabain分泌に関する検討2010
- Author(s)
  吉賀正亨,小宮山豊,高橋伯夫
- Organizer
  第33回日本高血圧学会総会
- Place of Presentation
  福岡国際会議場(福岡市)
- Year and Date
  2010-10-16
- Data Source
  KAKENHI-PROJECT-20590589
[Presentation] A mineralocorticoid receptor blocker, eplerenone decreases plasma levels of marinobufagenin-like immunoreactivity in rats.2010
- Author(s)
  Yoshika M, Komiyama Y, Yokoi T, Masuda M, Masaki H, Takahashi H
- Organizer
  International Symposium on Cardiovascular Endocrinology and Metabolism CVEM
- Place of Presentation
  奈良市新公会堂(奈良市)
- Year and Date
  2010-03-31
- Data Source
  KAKENHI-PROJECT-20590589
[Presentation] 高血圧発症機序における新規内因性ジギタリスの臨床検査学的研究2010
- Author(s)
  吉賀正亨、高橋伯夫、小宮山豊
- Organizer
  第57回日本臨床検査医学会学術集会
- Place of Presentation
  京王プラザホテル、東京
- Year and Date
  2010-09-11
- Data Source
  KAKENHI-PROJECT-21590643
[Presentation] A mineralocorticoid receptor blocker, eplerenone decreases plasma levels of marinobufagenin-like immunereactivity in rat2010
- Author(s)
  Yoshika M, Komiyama Y, Takahashi H, et al
- Organizer
  International Symposium on Cardiovascular Endocrinology and Metabolism
- Place of Presentation
  奈良県新公会堂、奈良
- Year and Date
  2010-04-01
- Data Source
  KAKENHI-PROJECT-21590643
[Presentation] Evidence for marinobufagenin-like immunoreactivity in the central nervous system.2010
- Author(s)
  Yoshika M, Komiyama Y, Takahashi H
- Organizer
  The 6th International Congress of Pathophysiology
- Place of Presentation
  International Conference Hall, Montreal, Canada
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-20590589
[Presentation] 内因性ジギタリス研究の現状と将来2010
- Author(s)
  高橋伯夫
- Organizer
  第33回日本高血圧学会総会
- Place of Presentation
  福岡国際会議場(福岡市)
- Year and Date
  2010-10-15
- Data Source
  KAKENHI-PROJECT-20590589
[Presentation] 高速液体クロマトグラフィーを用いた内因性ジギタリス様物質マリノブフォトキシンの分泌機構の検討2009
- Author(s)
  吉賀正亨, 小宮山豊, 高橋伯夫
- Organizer
  第45回高血圧関連疾患モデル学会学術総会
- Place of Presentation
  東京東京ステーションコンファレンス
- Year and Date
  2009-09-04
- Data Source
  KAKENHI-PROJECT-21590643
[Presentation] 高速液体クロマトグラフィーを用いた内因性ジギタリス様物質マリノブフォトキシンの存在様式の検討2009
- Author(s)
  吉賀正亨,小宮山豊,高橋伯夫
- Organizer
  第45回高血圧関連疾患モデル学会学術総会
- Place of Presentation
  東京ステーションコンファランス(東京都)
- Year and Date
  2009-09-04
- Data Source
  KAKENHI-PROJECT-20590589
[Presentation] Pathophysiological roles of endogenous digitalis, marinobufotoxin, in spontaneous hypertension in rats2009
- Author(s)
  吉賀正亨, 小宮山豊, 高橋伯夫
- Organizer
  第73回日本循環器学会総会・学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2009-03-20
- Data Source
  KAKENHI-PROJECT-20590589
[Presentation] 高速液体クロマトグラフィーを用いた内因性ジギタリス様物質マリノブフォトキシンの分泌機構の検討2009
- Author(s)
  吉賀正亨, 小宮山豊, 高橋伯夫
- Organizer
  第45回高血圧関連疾患モデル学会学術総会
- Place of Presentation
  東京ステーションコンファレンス、東京
- Year and Date
  2009-09-04
- Data Source
  KAKENHI-PROJECT-21590643
[Presentation] 副腎髄質における内因性ジギタリス様物質であるマリノブフォトキシンとアンジオテンシンについての検討2008
- Author(s)
  吉賀正亨, 小宮山豊, 高橋伯夫
- Organizer
  第31回日本高血圧学会総会
- Place of Presentation
  札幌
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Presentation] The Effect of Endogenous Digital is, Marinobufotoxin, in Sodium Metabolism2008
- Author(s)
  Yoshika, Y Komiyama, H Takahashi
- Organizer
  The 14^<th> International Symposium for SHR rat
- Place of Presentation
  Puraha
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Presentation] 副腎髄質における内因性ジギタリス様物質であるマリノブフォトキシンとアンギオテンシンについての検討2008
- Author(s)
  吉賀正亨, 小宮山豊, 高橋伯夫
- Organizer
  第31回日本高血圧学会総会
- Place of Presentation
  札幌国際会議場
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-20590589
[Presentation] Evidence of an Endogenous Digitalis, Marinobufotoxin, in the Sodium Metabolism2008
- Author(s)
  Yoshika M, Komiyama Y, Takahashi H
- Organizer
  13th International SHR Symposium
- Place of Presentation
  プラハ市(チェコ共和国)
- Year and Date
  2008-06-19
- Data Source
  KAKENHI-PROJECT-20590589
[Presentation] 副腎髄質における内因性ジギタリス様物質であるマリノブフォトキシンとアンギオテンシンについての検討2008
- Author(s)
  吉賀正亨,小宮山豊,高橋伯夫
- Organizer
  第31回日本高血圧学会総会
- Place of Presentation
  札幌国際会議場(札幌市)
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-20590589
[Presentation] 高血圧・食塩代謝におけるマリノブフォトキシンの役割の検討-高血圧自然発症ラットにナトリウム負荷とアンジオテンシン2受容体遮断薬を用いて-2008
- Author(s)
  吉賀正亨, 小宮山豊, 高橋伯夫
- Organizer
  第12回日本心血管内分泌代謝学会
- Place of Presentation
  熊本国際交流センター
- Year and Date
  2008-11-28
- Data Source
  KAKENHI-PROJECT-20590589
[Presentation] The effect of endo- genous digitalis, marinobufotoxin and angiotensin in rat adrenal gland2008
- Author(s)
  M Yoshika, Y Komiyama, H Takahashi
- Organizer
  The 31^<st> Japanese congress for hyper- tension
- Place of Presentation
  Sapporo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Presentation] The present situation and problem of the analytic instruments of clinical toxicology laboratory in hospital. The experience of three laboratory in west Japan.2008
- Author(s)
  Komiyama Y, Hara K, Takahashi H, Tsuda N, Ishibe T, Maruyama K, Hosaka N, Yahiro M, Hideshima R, Manago J
- Organizer
  The 30^<th> Japanese congress for clinical toxicology
- Place of Presentation
  Wakayama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Presentation] The Effect of Endogenous Digitalis, Marinobufotoxin, in Sodium Metabolism2008
- Author(s)
  M Yoshika, Y Komiyama, H Takahashi
- Organizer
  The 14^<th> International Symposium for SHR rat
- Place of Presentation
  Puraha, Czech Republic
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Presentation] 西日本3施設における薬毒物分析機器稼働の現状と課題2008
- Author(s)
  小宮山豊, 原克子, 高橋伯夫, 津田紀子, 丸山克之, 坂田育弘, 穂坂直美, 八尋美保子, 秀島里沙, 眞名子順一
- Organizer
  第30回日本中毒学会シンポジウム
- Place of Presentation
  和歌山
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Presentation] 食塩負荷ラットにおける新規内因性ジギタリス様物質であるマリノブフォトキシンの動態2007
- Author(s)
  吉賀正亨, 小宮山豊, 高橋伯夫
- Organizer
  第30回日本高血圧学会総会
- Place of Presentation
  那覇
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Presentation] The secretion of endo- genous digitalis, marinobufotoxin, in cultured cell, GH3, from hypothalamus2007
- Author(s)
  M Yoshika, Y Komiyama, H Takahashi
- Organizer
  The 54^<th> cogress for Japanese society of laboratory medicine
- Place of Presentation
  Osaka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Presentation] The effect of endo- genous digitalis, marinobufotoxin, on therat and cultured cells with salt loading.2007
- Author(s)
  M Yoshika, Y Komiyama, H Takahashi
- Organizer
  The 43rd Japanese conference of hyper- tension and related-model rats
- Place of Presentation
  Osaka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Presentation] 下垂体培養細胞GH3における内因性ジギタリス様物質(マリノブフォトキシン)の分泌動態の検討2007
- Author(s)
  吉賀正亨, 小宮山豊, 高橋伯夫
- Organizer
  第54回日本臨床検査医学会学術集会
- Place of Presentation
  大阪
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Presentation] The effect of endo- genous digitalis, marinobufotoxin, on the salt-loading rat2007
- Author(s)
  M Yoshika, Y Komiyama, H Takahashi
- Organizer
  The 30^<th> Japanese congress for hyper- tension
- Place of Presentation
  Naha
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590543
[Presentation] 内因性ジギタリス様物質であるマリノブッォトキシンの食塩負荷したラットおよび培養細胞における検討2007
- Author(s)
  吉賀正亨, 小宮山豊, 高橋伯夫
- Organizer
  第43回高血圧関連疾患モデル学会
- Place of Presentation
  大阪
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590543

1. KOMIYAMA Yutaka (40140264)

# of Collaborated Projects: 8 results

# of Collaborated Products: 43 results
2. EGAWA Hiroshi (20077663)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. MASUDA Midori (50173753)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. YOSHIKA Masamichi (70434834)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
5. KIRIDOSHI Masaya (10330185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAKATANI Toshio (70188978)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SHINYA Hiroshi (90309229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 津田信幸 (00121955)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 小坂知也 (10298862)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KOBAYASHI Kouji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TAKAHASHI Hakuo 高橋 伯夫

Research Projects

Research Products

Co-Researchers

Protective effects of endogenous digitalislike factor on the injury of kidney by aldosterone

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Studies on the role of endogenous digitalis in electrolytes and blood pressure regulationPrincipal Investigator

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Clinical Chemistry of Newly-found Esterase for Endogenous Digitalis-like Factor

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Clinical Chemistry of Newly-found Endogenous Bufalin Isomer in Saliva

Principal Investigator

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Structural analysis of endogenous digitalis and studies on the role of it in electrolytes and blood pressure control. In particular, studies on a novel substance, marinobufagenin with double hydrogen.Principal Investigator

Principal Investigator

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Research on the movement of antidotes and toxic metabolites in the patients with acetaminophen poisoning

Principal Investigator

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Research Institution

冠動脈疾患の危険因子としての抗クラミジアニューモニエ抗体価の臨床的意義に関する研究-内皮細胞由来血管作動性物質と凝固系分子マーカーからの基礎的検討-Principal Investigator

Principal Investigator

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IDENTIFICATION OF ENDOGENOUS DIGITALIS AND THE ROLE IN WATER-ELETROLYTES BALANCES AND BLOOD PRESSURE REGULATIONPrincipal Investigator

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動脈硬化症の病態に占めるセロトニン(5HT)_2受容体の役割の解明

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STUDIES ON IDENTIFICATION OF ENDOGENOUS DIGITALISLIKE FACTOR,AND THE ROLE IN WATER-ELECTROLYTES BALANCE AND BLOOD PRESSURE REGULATIONPrincipal Investigator

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The Correlation between IgA Isotype Anticardiolipin Antibodies and Thrombotic Events.

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Measurement of IgA Isotype Anticardiolipin Antibodies and Its Clinical Significance.

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SODIUM-INDUCED HYPERTENSION AND THE ENDOGENOUS DIGITALISLIKE FACTOR OF THE HYPOTHALAMIC ORIGINPrincipal Investigator

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TAKAHASHI Hakuo 高橋伯夫