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FUJIWARA KENJI  藤原 研司

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FUJIWARA Kenji  藤原 研司

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Researcher Number 80101088
Other IDs
External Links
Affiliation (Current) 2022: 独立行政法人労働者健康安全機構横浜労災病院(臨床病態研究センター), 臨床病態研究センター, 名誉院長
Affiliation (based on the past Project Information) *help 1994 – 2004: 埼玉医科大学, 医学部, 教授
1998: Saitama Medical School, Faculty of Medicine, Professor and Chairman, 医学部, 教授
1995: Saitama medical school : professor, 附属病院, 教授
1992 – 1993: 東京大学, 医学部(病), 講師
1990: University of Tokyo, Faculty of Medicine, Lecturer., 医学部・附属病院, 講師 … More
1987 – 1989: 東京大学, 医学部(病), 講師
1988: 東京大学, 医学部, 講師
1986: Tokyo University, Faculty of Medicine,, 医学部, 講師
1986: University of Tokyo, Faculty of Medicine, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Gastroenterology
Except Principal Investigator
Gastroenterology
Keywords
Principal Investigator
劇症肝炎 / 肝再生 / Osteopontin / 肝細胞膜 / liver regeneration / クッパー細胞 / 類洞内皮細胞 / 肝移植 / 肝類洞内皮細胞 / VEGF … More / SNP / Cytokine / 血管内凝固 / マクロファ-ジ / オルニシン脱炭酸酵素 / 内皮細胞 / 培養肝細胞 / ポリアミン代謝 / オルニシン脱炭酵素 / 分子生物学 / 肝再生促進因子 / fulminant hepatitis / intravascular coagulation / macrophage / ornithine decarboxylase / plasma membrane / cultured hepatocyte / polyamine / 肝細胞増殖因子 / プトレスシン / TGFβ / Hepatocyte plasma membrane / Hepatocyte growth factor / Putrescine / TGFbeta / 急性肝不全 / 肝類洞内凝固 / primary graft nonfunction / トロンボモジュリン / 組織因子 / 肝マクロファージ / fulminant hepatitie / acute liver failure / sinusoidal fibrin doposition / Kupffer cells / sinusoidal endothetial cells / 微小循環障害 / 星細胞 / オステオポチン / トランスジェニックマウス / 肝星細胞 / angiopoiein / Tie受容体 / osteopontin / Angiopoietin / TIE受容体 / 肝移植後肝不全 / pericyte / 微小循環 / ヘパリン / プロテオグリカン / Liver transplantation / Microcirculatory disturbance / Sinusoidal endothelial cell / Kupffer cell / Stellate cell / Transgenic mouse / Th1免疫応答 / C型慢性肝炎 / 自己免疫性肝炎 / インターフェロン / 肝炎活動性 / オステオポンチン / サイトカイン / Th1 immune reaction / Chronic hepatitis C / Auto immune hepatitis / Interferon / Hepatitis activity / 線維肝 / コラゲン / マクロファージ / 超酸化物イオン / アラビアゴム / Hepatic fibrosis / Collagen / Macrophage / Superoxide … More
Except Principal Investigator
VEGF / COX-2 / 肝再生 / 肝細胞 / 肝類洞内皮細胞 / TFPI / 肝星細胞 / PCPE / PDGF / KDR / flk-1 / Liver Regeneration / TNF / NFκB / マクロファージ / プロスタグランジン / PPAR / prostaglandin / 上皮成長因子 / 肝細胞膜 / 細胞増殖 / 肝細胞増殖 / 蛋白 / hepatocytes / plasma membrane / cell growth / 肝移植 / 肝不全 / トロンボモジュリン / 類洞内皮細胞 / Liver transplantation / Liver failure / Sinusoidal endothelial cell / Thrombomodulin / RNA結合蛋白 / 平滑筋αアクチン / コラゲン / bFGF / TGFβ / Hepatic Stellate Cell / RNA-binding Protein / Smooth Muscle α Actin / 劇症肝炎 / flt-1 / fet-1 / Fulminant Hepatic Failure / Sinusoidal Endothelial Cells / ft-1 / アポトーシス / IAP(inhibitor of apoptosis) / D-galactosamine / エンドトキシン / 肝壊死 / apoptosis / IAP (inhibitor of apoptosis protein) / hepatocyte / macrophage / 大腸癌 / 大腸腺腫 / 受容体 / 血管内皮増殖因子 / PPARγ / colon cancer / CIX-2 / 胃過形成性ポリープ / 胃腺腫 / ヘリコバクター・ピロリ / cDNAマイクロアレイ / 血管新生 / 癌化 / 胃癌 / gastric hyperplastic polyp / gastric adenoma / Helicobacter pylori / cDNA microarray / angiogenesis / carcinogenesis / 急性肝不全 / グルカゴン・インスリン療法 / 血漿交換 / 抗トロンビン【III】 / オルニチンデカルボキシラーゼ / プロスタグランヂン誘導体 / 肝障害 / 交換輸血 / 血管内凝固 / アンチトロンビン【III】 / インスリン・グルカゴン療法 / Acute liver failure / Liver regeneration / Cytoprotection / Exchange transfusion / Glucagon / Insulin / Ornithine decarboxylase / 増殖因子 / 血小板 / イムノアッセイ / Epidermal Growth Factor / Growth Factor / Platelet Less
  • Research Projects

    (15 results)
  • Research Products

    (8 results)
  • Co-Researchers

    (16 People)
  •  Genetic Polymorphisms in Promoter Regions of Osteopontin Gene as Host Factors to Determine Th1 Immune Reactions against Hepatitis Virus.Principal Investigator

    • Principal Investigator
      FUJIWARA Kenji
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Saitama Medical School
  •  Role of COX-2 in the development of gastric tumor by Helicobacter Pylori

    • Principal Investigator
      ARAI Shin
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Saitama Medical School
  •  Roles of cell surface membrane and nuclear prostaglandin receptors in growth factor production during colon carcinogenesis

    • Principal Investigator
      OTA Shinichi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Saitama Medical School
  •  Study on Strategies for Non-Heart Beating LiverPrincipal Investigator

    • Principal Investigator
      FUJIWARA Kenji
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Saitama Medical School
  •  Mechanisms of Development of Massive Necrosis and Regeneration after Liver Injury Regulated by Activated Sinusoidal Macrophages

    • Principal Investigator
      NAGOSHI Sumiko
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Saitama Medical School
  •  The Mechanisms of Hepatic Stellate Cell Activation : Possible Contribution of Type I Procollagen C-Proteinase Enhancer Protein.

    • Principal Investigator
      MATSUI Atsushi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Saitama Medical School
  •  The Mechanisms of Impaired Liver Regeneration in Fulminant Hepatic Failure : The Significance of Sinusoidal Endothelial Cell Proliferation.

    • Principal Investigator
      MOCHIDA Satoshi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Saitama Medical School
  •  Anticoagulant Targeting the Hepatic Sinusoids for Liver Injury Following Orthotopic Liver Transplantation

    • Principal Investigator
      MOCHIDA Satoshi
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Saitama Medical School
  •  New devices in anticoagulant therapy for massive hepatic necrosis through sinusoidal fibrin depositionPrincipal Investigator

    • Principal Investigator
      FUJIWARA Kenji
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Saitama Medical School
  •  purification of growth stimulatory factor in rat liver plasma membrane

    • Principal Investigator
      HIRATA Keiichi
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Tokyo
  •  Purification of hepatocyte comitogenic factor in plasma membrane and its action site (s) in hepatocyte proliferation.Principal Investigator

    • Principal Investigator
      FUJIWARA Kenji
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Tokyo
  •  Factors Associated with Insufficient Liver Regeneration in Fulminant Hepatic FailurePrincipal Investigator

    • Principal Investigator
      FUJIWARA Kenji
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Tokyo
  •  Platelet Epidermal Growth Factor and Liver Regeneration

    • Principal Investigator
      IKEDA Hitoshi, 岡 裕爾
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Tokyo
  •  ROLE OF SUPEROXIDE FROM MACROPHAGES IN HEPATIC FIBROSISPrincipal Investigator

    • Principal Investigator
      FUJIWARA Kenji
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Tokyo
  •  TREATMENT OF ACUTE LIVER FAILURE BY STIMULATION OF LIVER REGENERATION AND CYTOPROTECTION

    • Principal Investigator
      OKA Hiroshi
    • Project Period (FY)
      1984 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo University

All 2004 2003 Other

All Journal Article Patent

  • [Journal Article] Plasma Osteopontin Levels in Patients with Fulminant Hepatitis2004

    • Author(s)
      Matsui A, Mochida S, Ohno A, Nagoshi S, Hirose T, Fujiwara K
    • Journal Title

      Hepatology Res 22

      Pages: 202-206

    • NAID

      10018024812

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370191
  • [Journal Article] Genetic Polymorphisms in Promoter Region of Osteopontin Gene May be a Marker Reflecting Hepatitis Activity in Chronic Hepatitis C Patients2004

    • Author(s)
      Mochida S, Hashimoto M, Matsui A, Naito M, Inao M, Nagoshi S, Egashira T, Mishiro S, Fujiwara K
    • Journal Title

      Biochem Biophys Res Commun 313

      Pages: 1079-1085

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370191
  • [Journal Article] Transgenic Mice Expressing Osteopontin in Hepatocytes as a Model of Autoimmune Hepatitis2004

    • Author(s)
      Mochida S, Yamamoto T, Mimura S, Matsui A, Ohno A, Koh H, Saitoh E, Nagoshi S, Fujiwara K
    • Journal Title

      Biochem Biophys Res Commun 317

      Pages: 114-120

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370191
  • [Journal Article] Extrahepatic manifestation in Transgenic Mice of Osteopontin in Hepatocytes : A Clue to Advent of Pathological State in Various Organs of Chronic Hepatitis C Patients

    • Author(s)
      Saitoh E, Matsui A, Inao M, Mimura S, Koh H, Ohno A, Nagoshi S, Kayano H, Yoshimoto T, Mochida S, Fujiwara K
    • Journal Title

      Hepatol Res (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370191
  • [Journal Article] SNPs in the Promoter Region of Osteopontin Gene as a Marker Predicting the Efficacy of Interferon-Based Therapies in Chronic Hepatitis C

    • Author(s)
      Naito M, Matsui A, Inao M, Nagoshi S, Nagano M, Ito N, Egashira T, Hashimoto M, Mishiro S, Mochida S, Fujiwara K
    • Journal Title

      J Gastroenterol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370191
  • [Journal Article] Increased Cytoprotective Function in the Liver of Transgenic Mice Expressing Osteopontin in Hepatocytes

    • Author(s)
      Koh H, Matsui A, Mimura S, Inao M, Saitoh E, Ohno A, Nagoshi S, Yoshimoto T, Mochida S, Fujiwara K
    • Journal Title

      Hepatol Res (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370191
  • [Patent] 感染による病変の程度を予測するためのデータを収集する方法2003

    • Inventor(s)
      持田 智, 藤原 研司, 三代 俊治, 他
    • Industrial Property Rights Holder
      株式会社東芝
    • Filing Date
      2003-09-24
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370191
  • [Patent] 感染による病変の程度を予測するためのデータを収集する方法2003

    • Inventor(s)
      持田 智, 藤原 研司, 三代 俊治, 他
    • Industrial Property Rights Holder
      株式会社東芝
    • Filing Date
      2003-09-24
    • Data Source
      KAKENHI-PROJECT-14370191
  • 1.  MOCHIDA Satoshi (20219968)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 6 results
  • 2.  NAGOSHI Sumiko (50306271)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 6 results
  • 3.  INAO Mie (70286037)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 4 results
  • 4.  MATSUI Atsushi (40260484)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 6 results
  • 5.  OGATA Itsuo (80169169)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  TOMIYA Tomoaki (90227637)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  HIRATA Keiichi (50199064)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  OTA Shinichi (30185269)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  ARAI Shin (20306294)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  OKA Yuji (20160658)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  OHTA Yasuhiko (60124666)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  IKEDA Hitoshi (80202422)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  YAMANOBE Fumio (90286097)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  OKA Hiroshi (10010258)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  佐藤 譲
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  SATO Yuzuru
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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