YAMAMOTO Yukio 山本行男

Researcher Number	80124501
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2008: Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 主任研究員 2008: Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 主任研究員 2007: 東京都臨床医学総合研究所, 主任研究員 2007: Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, Senior Researcher 2005 – 2006: Tokyo Metropolitan Organization for Medical Research, Tokyo Metropolitan Institute of Medical Science, Chief Researcher, 東京都臨床医学総合研究所, 主任研究員 … More 2002 – 2004: 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 主任研究員 2003: Tokyo Metropolitan Organization of Medical Science, Tokyo Metropolitan Institute of Medical Science, Researcher, 東京都臨床医学総合研究所, 主任研究員 1999: 東京都・臨床医学研究所, 主任研究員 1999: The Tokyo Metropolitan Institute of Medical Science, Chief Researcher, 主任研究員 1999: Tokyo Metropolitan Institute of Medical Science Researcher, 東京都臨床医学総合研究所, 研究員 1998: 東京都臨床医学総合研究所, 化学療法部, 主任研究員 1998: 財団法人東京都臨床医学総合研究所, 化学療法研究部門, 研究員 1996: THE TOKYO METROPOLITAN INSTITUTE OF MEDICAL SIENCE,CANCER THERAPEUTICS,SCIENTIST, 化学療法研究部門, 研究員 1995: 財団法人東京都臨床医学総合研究所, 化学療法研究部門, 研究員 1990: Researcher, Tumor Biology Section, The Tokyo Metropolitan Institute of Medical S, 腫瘍細胞研究部門, 研究員 1989: (財)東京都臨床医学総合研究所, 腫瘍細胞, 研究員 Less
Review Section/Research Field	Principal Investigator 応用薬理学・医療系薬学 / Anesthesiology/Resuscitation studies Except Principal Investigator Laboratory medicine / Anesthesiology/Resuscitation studies / 応用薬理学・医療系薬学 / 応用生物化学・栄養化学 / Applied pharmacology
Keywords	Principal Investigator spinorphin / 内因性物質 / Spinorphin / 関節炎 / Disease-associated protein / Proteomics / Cerebrospinal fluid / Rheumatoid Arthritis / 病態関連蛋白質 / 質量分析 … More / dipeptidyl peptidase III / proteomics / dipeptidyI peptidase III / EIA / Endogenous peptide / Dipeptidyl peptidase III / Pan / 酵素免疫測定法 / 炎症制御 / 疼痛制御 / スパイノルフィン / dipeptidyl peptidase / inflammation / an endogenous factor / sipnorphin / 生体防御機構 / 免疫抗体法 / 疼痛制御物質 / プロテオーム / 免疫沈降 / 蛋白質変成 / L-PGDS / 脊髄液 … More Except Principal Investigator Leuhistin / Spinorphin / bradykinin / Ni-NTA / dipeptydylaminopeptidase / aminopeptidase / enkephalin / spinorphin / Aminopeptidase N / Anti-inflammatory / Enkephalin / cDNA / Bip / GRP78 / 2D-electrophoresis / proteome / malignamcy / phosphotyroisine-containing proteins / glioma / 二次元電気泳道 / 二次元電気泳動 / プロテオーム / 病態 / チロシンリン酸化たんぱく質 / グリオーマ / substance P receptor / substance P / PMN / substanceP receptor / substanceP / 炎症制御機構 / 好中球機能 / Enkephalin調節因子 / AmincpeptidaseN / Oligosaccharyltransferase / Glycosyltransferase / Glycosylation / Cell growth / Mutant / Oligosaccharideーlipid / 粗面小胞体 / トリチウム自殺法 / 温度感受性変異株 / クロ-ニング / リピド中間体 / 細胞増殖 / アスパラギン結合型糖鎖 / 変異株 / 糖転移酵素 / オリゴ糖転移酵素 / オリゴ糖ーリピド / 疼痛制御 / インヒビター / リウマチ / スパイノルヒン Less

Proteomic analysis of pain-regulated and amyloid components in cerebrospinal fluid of patients with rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Yukio
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Analysis of phosphotyroisine-containing proteins related to the malignancy in gliomas by proteomic differential display
- Principal Investigator
  
  YAMAOKA Kazuko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Studies in a new pain control of spinorphin, an endogenous peptide, in rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Yukio
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
新しい脊髄由来疼痛制御物質スパイノルフィンの生体における役割
- Principal Investigator
  
  HAZATO Tadahiko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Studies in~a new pain control by spinorphin, an endogenous factor : Changes in level of spinorphin and dipeptidyl peptidase III in cerebrospinal fluid from patients with painPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Yukio
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo Metropolitan Organization of Medical Science
Study on the function of endogenous opioid and substance P at inflammation and pain
- Principal Investigator
  
  NISHIMURA Kinya
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Juntendo University
Studies in anti-inflammatory effect of spinorphin, an endogenous factorPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Yukio
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo Metropolitan Organization of Medical Science
A study on function mechanism of a novel endogenous
- Principal Investigator
  
  HAZATO Tadahiko
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  THE TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE
Molecular Cloning of Human cDNA Encoding a Mannosyltransferase Activity Involved in the Synthesis of the Lipid Intermediate.
- Principal Investigator
  
  NISHIKAWA Yoshihisa
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用生物化学・栄養化学
- Research Institution
  The Tokyo Metropolitan Institute of Medical Science

All 2008 2007 2006 2005 2004

All Journal Article Presentation

[Journal Article] Involvement of sperm protease in the binding of sperm to the vitelline envelope in Xenopus laevis.2008
- Author(s)
  Kubo, H., Kotani, M., Yamamoto, Y., Hazato, T.
- Journal Title
  
  Zool. Sci. 25
  
  Pages: 80-87
- NAID
  40015869847
- Data Source
  KAKENHI-PROJECT-19591828
[Journal Article] 脊髄由来プロテアーゼ阻害物質spinorphinの疼痛時における動態2008
- Author(s)
  林健児、山本行男、伊藤雄策、岡崎敦、羽里忠彦
- Journal Title
  
  ペインクリニック 29
  
  Pages: 207-210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591828
[Journal Article] Involvement of sperm protease in the binding of sperm to the vitelline envelope in Xenopus laevis2008
- Author(s)
  Hideo Kubo, Masaharu Kotani, Yukio Yamamoto, Tadahiko Hazato
- Journal Title
  
  Zool. Sci. 25
  
  Pages: 80-87
- NAID
  40015869847
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591828
[Journal Article] 脊髄由来のプロテアーゼ阻害物質spinorphinの疼痛時における動態2008
- Author(s)
  林健児、山本行男、伊藤雄策、岡崎敦、羽里忠彦
- Journal Title
  
  ペインクリニック 29
  
  Pages: 207-210
- Data Source
  KAKENHI-PROJECT-19591828
[Journal Article] 周術期尿中アミノペプチダーゼMの動態2007
- Author(s)
  鈴木恵子、山本行男、羽里忠彦
- Journal Title
  
  ペインクリニック 28
  
  Pages: 1615-1619
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591828
[Journal Article] 周術期アミノペプチダーゼMの動態2007
- Author(s)
  鈴木恵子、山本行男、羽里忠彦、稲田英一、宮崎東洋
- Journal Title
  
  ペインクリニック 28
  
  Pages: 1615-1619
- Data Source
  KAKENHI-PROJECT-19591828
[Journal Article] Two-dimensional electrophoretic analysis of disease-associated proteins in human cerebrospinal fluid from patients with rheumatoid arthritis.2005
- Author(s)
  Yamamoto, Y. et al.
- Journal Title
  
  J. Electrophoresis 49(1)
  
  Pages: 23-27
- NAID
  10015570338
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591577
[Journal Article] 新しい疼痛抑制物質spinorphinの疾病時における動態-関節リウマチ患者の脳脊髄液において-2005
- Author(s)
  田井重行, 小原京子, 遠田正治, 山本行男, 羽里忠彦
- Journal Title
  
  ペインクリニック第25巻
  
  Pages: 1656-1660
- Data Source
  KAKENHI-PROJECT-16591577
[Journal Article] Levels of spinorphin in cerebrospinal fluid derived from patients with increase with decreasing dipeptidyl peptidase III.2005
- Author(s)
  Yamamoto, Y.et al.
- Journal Title
  
  Pain Research 20(1)
  
  Pages: 27-34
- Data Source
  KAKENHI-PROJECT-16591577
[Journal Article] Levels of spinorphin in cerebrospinal fluid derived from patients with pain increases with decreasing dipeptidyl peptidase III.2005
- Author(s)
  Yamamoto, Y. et al.
- Journal Title
  
  Pain Research 20(1)
  
  Pages: 27-34
- NAID
  10015444541
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591577
[Journal Article] Levels of spinorphin in cerebrospinal fluid derived from patients with pain increase with decreasing dipeptidyl peptidase III.2005
- Author(s)
  Yamamoto, Y. et al.
- Journal Title
  
  Pain Research 20(1)
  
  Pages: 27-34
- NAID
  10015444541
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591577
[Journal Article] Two-dimensional electrophoretic analysis of disease-associated proteins in human cerebrospinal fluid from patients with rheumatoid arthritis.2005
- Author(s)
  Yamamoto, Y.et al.
- Journal Title
  
  J.Electrophoresis 49(1)
  
  Pages: 23-27
- NAID
  10015570338
- Data Source
  KAKENHI-PROJECT-16591577
[Journal Article] Bovine lactoferrin inhibits tumor-induced angiogenesis.2004
- Author(s)
  Yamamoto, Y. et al.
- Journal Title
  
  Int.J.Cancer 111
  
  Pages: 111-116
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591577
[Presentation] 疼痛患者の脊髄液におけるL-PGDSとその代謝産物の動態に関する検討2008
- Author(s)
  中村里依太、木村光兵、佐藤洋、鈴木尚生子、佐藤和恵、山本行男
- Organizer
  日本麻酔科学会第55回学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19591828
[Presentation] 大腸癌における尿プロテオーム解析による病態マーカーの探索:第二報2008
- Author(s)
  山本行男, 平松恭子, 高橋慶一, 山岡和子, 秋田朗子
- Organizer
  日本ヒトプロテオーム機構第6回大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19591828
[Presentation] Changes in levels of prostaglandin D_2 metabolite in cerebrospinal fluids of rheumatoid patients2008
- Author(s)
  Yamamoto, Y., Akita, Y., Shimamura, M., Sato, H., Fukasaku, S., Aritake, K.
- Organizer
  7^<th> Annual World Congress Human Proteome Organization (HUPO) 2008
- Place of Presentation
  Amsterdam(Netherland)
- Data Source
  KAKENHI-PROJECT-19591828
[Presentation] グリオーマの分子病態マーカーの探索2008
- Author(s)
  山岡和子、三島一彦、松谷雅生、西川亮、山本行男、廣井隆親
- Organizer
  日本ヒトプロテオーム機構第6回大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19591828
[Presentation] 神経ブロックによる疼痛管理における直腸がん患者の脊髄液プロテオーム解析2008
- Author(s)
  山本行男、佐藤洋、久保英夫、芦野洋美、木村光兵
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19591828
[Presentation] 大腸癌における尿プロテオーム解析2008
- Author(s)
  山本行男
- Organizer
  日本ヒトプロテオーム機構
- Place of Presentation
  東京
- Year and Date
  2008-07-30
- Data Source
  KAKENHI-PROJECT-18590546
[Presentation] Changes in levels of prostaglandin D2 metabolite in cerebrospinal fluids of rheumatoid patients.2008
- Author(s)
  Yamamoto, Y., Akita, Y., Shimamura, M., Sato, H., Fukasaku, S., Aritake, K.
- Organizer
  7^<th> Annual World Congress Human Proteome Organization (HUPO)2008
- Place of Presentation
  Amsterdam (Netherland)
- Data Source
  KAKENHI-PROJECT-19591828
[Presentation] Changes in levels of prostaglandin D_2 metabolite in cerebrospinal fluidsor rheumatoid patients.2008
- Author(s)
  Yamamoto, Y
- Organizer
  7th Annual World Congress
- Place of Presentation
  Amsterdam
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590546
[Presentation] Changes in levels of prostaglandin D_2 metabolite in cerebrospinal fluidsof rheumatoid patients.2008
- Author(s)
  Yukio Yamamoto
- Organizer
  7th Annual World Congress
- Place of Presentation
  Amsterdam
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590546
[Presentation] 大腸癌における尿プロテオーム解析による病態マーカーの探索 : 第二報2008
- Author(s)
  山本行男、平松恭子、高橋慶一、山岡和子、秋田朗子
- Organizer
  日本ヒトプロテオーム機構第6回大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19591828
[Presentation] カルパインの阻害による血管腔形成の制御2008
- Author(s)
  芦野洋美、鈴木直子、小野富男、山本行男、島村眞里子
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19591828
[Presentation] ラット下垂体由来GH 細胞においてTRH 刺激で活性化されたPKCεはケラチン8のSer8とSer23をリン酸化する2007
- Author(s)
  秋田朗子、大海忍、福田宏之、川崎博史、山本行男、大野茂男、平野久、小野功貴、米川博通
- Organizer
  第30回日本分子生物学会年会第80回日本生化学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19591828
[Presentation] L-carnosine, an endogenous bioactive dipeptide inhibits angiogenesis and tumor metastasis.2007
- Author(s)
  Shimamura, M., Ashino, H., Shimizu, M., Yamamoto, Y., Minamikawa-Tachino, R., Takahashi, S.
- Organizer
  The 66^<th> Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-19591828
[Presentation] ジペプチドL-carnosineによる血管新生の阻害と抗腫瘍作用2007
- Author(s)
  島村眞里子, 芦野洋美, 飯郷正明, 山本行男
- Organizer
  第15回日本血管生物医学会学術大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19591828
[Presentation] 脊髄液における疹痛関連物質の動態解析2007
- Author(s)
  東賢志、佐藤洋、木村光兵、秋田朗子、山本行男
- Organizer
  日本痳酔科学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19591828
[Presentation] 変形性関節症および関節リウマチ患者の脊髄液におけるPGE_2、およびPGD_2、の動態.2007
- Author(s)
  山本行男、佐藤洋、岡崎敦、林健児、西村欣也、久保英夫、島村真里子、秋田朗子
- Organizer
  第80回日本生化学大会第30回日本分子生物学会大会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19591828
[Presentation] ヒトグリオーマの悪性化に関与するチロシンリン酸化蛋白質の検索2007
- Author(s)
  山岡和子、三島一彦、西川亮、松谷雅生、秋田朗子、山本行男、廣井隆親
- Organizer
  日本ヒトプロテオーム機構第5回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591828
[Presentation] 変形性関節症および関節リウマチ患者の脊髄液におけるPGE_2およびPGD_2の動態2007
- Author(s)
  山本行男、佐藤洋、岡崎敦、林健児、西村欣也、久保英夫、島村眞里子、秋田朗子
- Organizer
  第30回日本分子生物学会年会第80回日本生化学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19591828
[Presentation] 脊髄液における疼痛関連物質の動態解析2007
- Author(s)
  東賢志、佐藤洋、木村光兵、秋田朗子、山本行男
- Organizer
  日本麻酔科学会第54回学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19591828
[Presentation] 大腸癌における尿プロテオーム解析(第一報)解析条件の基礎的検討2007
- Author(s)
  山本行男、高橋慶一、佐藤功栄、平松恭子、山岡和子、島村真里子、久保英夫、秋田朗子
- Organizer
  日本ヒトプロテオーム機構第5回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591828
[Presentation] 大腸癌における尿プロテオーム解析: (第一報)解析条件の基礎的検討2007
- Author(s)
  山本行男
- Organizer
  日本ヒトプロテオーム機構
- Place of Presentation
  横浜
- Year and Date
  2007-07-30
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590546
[Presentation] 脊髄液における疼痛関連物質の動態解析2006
- Author(s)
  山本行男
- Organizer
  日本ヒトプロテオーム機構
- Place of Presentation
  東京
- Year and Date
  2006-07-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590546
[Presentation] Proteomic analysis of disease-associated proteins in cerebrospinal fluid from patients with rheumatoid arthritis.2006
- Author(s)
  Yamamoto, Y
- Organizer
  20^<th> IUBMB international congress of bioc hemistry and molecular biology and 11^<th> FAOBMB congress.
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590546
[Presentation] Proteomic analysis of disease-associated proteins in cerebrospinal fluid from patients with rheumatoid arthriris.2006
- Author(s)
  Yamamoto, Y.
- Organizer
  20th IUBMB international congress of biochemistry and molecular biology and 11th FAOBMB congress.
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590546

1. HAZATO Tadahiko (60109949)

# of Collaborated Projects: 6 results

# of Collaborated Products: 1 results
2. NISHIMURA Kinya (80164581)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
3. AKITA Yoshiko (40124432)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
4. YAMAOKA Kazuko (00124438)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. KUGIMIYA Toyoki (90010537)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TAKAHASHI Keiichi (60443115)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. KUBO Hideo (50178034)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
8. NISHIKAWA Yoshihisa (20109953)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MISHIMA Kazuhiko (00282640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YAMAMOTO Yukio 山本 行男

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Proteomic analysis of pain-regulated and amyloid components in cerebrospinal fluid of patients with rheumatoid arthritisPrincipal Investigator

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Analysis of phosphotyroisine-containing proteins related to the malignancy in gliomas by proteomic differential display

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Studies in a new pain control of spinorphin, an endogenous peptide, in rheumatoid arthritisPrincipal Investigator

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新しい脊髄由来疼痛制御物質スパイノルフィンの生体における役割

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Studies in~a new pain control by spinorphin, an endogenous factor : Changes in level of spinorphin and dipeptidyl peptidase III in cerebrospinal fluid from patients with painPrincipal Investigator

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Study on the function of endogenous opioid and substance P at inflammation and pain

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Studies in anti-inflammatory effect of spinorphin, an endogenous factorPrincipal Investigator

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A study on function mechanism of a novel endogenous

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Molecular Cloning of Human cDNA Encoding a Mannosyltransferase Activity Involved in the Synthesis of the Lipid Intermediate.

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[Journal Article] Involvement of sperm protease in the binding of sperm to the vitelline envelope in Xenopus laevis.2008

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[Journal Article] 脊髄由来プロテアーゼ阻害物質spinorphinの疼痛時における動態2008

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[Journal Article] Involvement of sperm protease in the binding of sperm to the vitelline envelope in Xenopus laevis2008

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[Journal Article] 脊髄由来のプロテアーゼ阻害物質spinorphinの疼痛時における動態2008

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[Journal Article] 周術期尿中アミノペプチダーゼMの動態2007

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YAMAMOTO Yukio 山本行男