AKAGAWA kimio 赤川公朗

… Alternative Names

赤川公朗アカガワキミオ

AKAGAWA Kimio 赤川公朗

赤川公郎アカガワキミオ

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Researcher Number	80129303
Other IDs
External Links
Affiliation (Current)	2025: 杏林大学, 医学部, 名誉教授
Affiliation (based on the past Project Information) *help	2012 – 2014: 杏林大学, 医学部, 教授 2007 – 2009: Kyorin University, 医学部, 教授 1999 – 2000: 杏林大学, 医学部, 教授 1993 – 1997: 杏林大学, 医学部, 教授 1989 – 1991: 岡崎国立共同研究機構, 生理学研究所, 助教授 1988: 埼玉医科大学, 生理学, 講師
Review Section/Research Field	Principal Investigator Neurophysiology and muscle physiology / Neuroscience in general / Neurophysiology and muscle physiology / Neurochemistry/Neuropharmacology Except Principal Investigator 神経・脳内生理学 / Obstetrics and gynecology / 小児外科
Keywords	Principal Investigator HPC-1 / 開口放出 / syntaxin1A / syntaxin1B / 遺伝子ノックアウトマウス / シンタキシン1B / シンタキシン1A / シナプス伝達 / カイニン酸 / 最初期遺伝子 … More / 海馬 / 神経可塑性 / Light response / Layer formation / Reaggregate culture / Rat retina / 層構造 / パッチクランプ法 / アマクリン細胞 / 光応答 / 層構築 / 再凝集培養 / ラット網膜 / REGULATED SECRETION / NEURITE SPROUTING / EXOCYTOSIS / SYNTAXIN 1A / 長期増強 / 制御性分泌 / 神経発芽 / ノックアウトマウス / 神経成長因子 / シンタキシン１B / haploid / 自閉性障害 / 遅い神経伝達物質放出過程 / 速い神経伝達物質放出過程 / シンタキシン１Ｂ / シンタキシン１A / BDNF / グリア細胞 / 機能分化 / 神経伝達 / 疾患モデル / 自閉症 / シンタキシン1 / 運動障害 / 痙攣発作 / 致死 / 遅い神経伝達 / 速い神経伝達 / 行動異常 / シナプス伝達制御因子 / シナプス機能分化 / 疾患モデル動物 / ノックアウトマウス自閉性障害 / LTP / 培養 / 遅発性神経細胞死 / 脱抑制 / GABA / 2デオキシグルコ-ス / 黒質 / 線条体 … More Except Principal Investigator シンタキシン / HPC-1 / vesicle-associated membrane protein (VAMP) / syntaxin / exocytosis / testis / spermatozoa / oocytes / VAMP / 開口放出 / 精巣 / 精子 / 卵子 / exocytosis-related protein / Hirschsprung's disease / HPC-1 antigen / 無神経節部腸管 / HPC-1蛋白 / 無神経節腸管 / ヒルシュスプルング病 / 培養神経細胞 / 海馬 / 脊髄後根神経節 / アンチセンスオリゴヌクレオチド / パッチクランプ法 / Caチャネル / 出芽 / シナプトファイシン / ホールセル・クランプ法 / 神経突起末端部 / 単離培養系 / 脊髄後根神経節細胞 / アンチセンスDNA Less

Functional difference between syntaxin1 isoforms in synaptic transmissionPrincipal Investigator
- Principal Investigator
  
  AKAGAWA kimio
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Kyorin University
Analysis of syntaxin 1 gene knockout mice as an animal model for autistic disorderPrincipal Investigator
- Principal Investigator
  
  AKAGAWA Kimio
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kyorin University
Expression and role of exocytotic SNARE proteins on oocyte cortical reaction
- Principal Investigator
  
  KUJI Naoaki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  KEIO UNIVERSITY
神経可塑性に関わる神経特異蛋白質HPC-1の研究Principal Investigator
- Principal Investigator
  
  赤川公朗
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyorin University
STUDY OF A NEURON-SPECIFIC PROTEIN,HPC-1, WHICH REGULATES NEURONAL SPROUTING.Principal Investigator
- Principal Investigator
  
  AKAGAWA Kimio
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  KYORIN UNIVERSITY
Immunohistochemical studies of abnormal extrinsic nerve fibers in Hirschsprung's disease
- Principal Investigator
  
  NIRASAWA Yuji
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  小児外科
- Research Institution
  Kyorin University
神経突起末端部における神経細胞膜蛋白質HPC-1の機能に関する生理学的研究
- Principal Investigator
  
  山口和彦
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  神経・脳内生理学
- Research Institution
  Kyorin University
シナプス前膜蛋白質に対するアンチセンスDNA等を用いた神経伝達物質放出機構の解析
- Principal Investigator
  
  YAMAGUCHI Kazuhiko
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  神経・脳内生理学
- Research Institution
  Kyorin University
組織培養法による経シナプス性黒質神経細胞死の機序・防御の研究Principal Investigator
- Principal Investigator
  
  赤川公朗
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Okazaki National Research Institutes
Studies of Neuronal Properties in the Reaggregate Cultures of Rat RetinanePrincipal Investigator
- Principal Investigator
  
  AKAGAWA Kimio
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Okazaki National Research Institutes
  Saitama Medical University

All 2015 2014 2013 2009 2008 Other

All Journal Article Presentation Book

[Book] 基礎医学(クルズス診療科(4))2008
- Author(s)
  赤川公朗(編, 共著)
- Total Pages
  352
- Publisher
  星和書店
- Data Source
  KAKENHI-PROJECT-19300133
[Journal Article] ER stress response in NG108-15 cells involves upregulation of syntaxin 5 expression and reduced amyloid beta peptide secretion.2015
- Author(s)
  K.Suga, A.Saitoh, and K.Akagawa
- Journal Title
  
  Ｅｘｐｅｒｉｍｅｎｔａｌ　ｃｅｌｌ　ｒｅｓｅａｒｃｈ
  
  Volume: 332 Pages: 11-23
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24300142
[Journal Article] Presynaptic inhibitory actions of pregabalin on excitatory transmission in superficial dorsal horn of mouse spinal cord: further characterization of presynaptic mechanisms2014
- Author(s)
  Matsuzawa R, Fujiwara T, Nemoto K, Fukushima T, Yamaguchi S, Akagawa K, Hori Y
- Journal Title
  
  Neuroscience Letters
  
  Volume: 558 Pages: 186-191
- DOI
  10.1016/j.neulet.2013.11.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500468, KAKENHI-PROJECT-24300142
[Journal Article] Syntaxin 1B, but Not Syntaxin 1A, is Necessary for the Regulation of Synaptic Vesicle Exocytosis and of the Readily Releasable Pool at Central Synapses2014
- Author(s)
  T.Mishima, T.fujiwara, M.Sanada, T.Kofuji ,M.Kanai &K.Akagawa
- Journal Title
  
  PLoS ONE.
  
  Volume: 9 Issue: 2 Pages: e90004-e90004
- DOI
  10.1371/journal.pone.0090004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24300142, KAKENHI-PROJECT-24500462
[Journal Article] The syntaxin 5 isoforms Syx5 and Syx5L have distinct effects on the processing of s-amyloid precursor protein.2009
- Author(s)
  K. Suga, A. Saito, T. Tomiyama, H. Mori, K. Akagawa
- Journal Title
  
  J. Biochem Vol.146
  
  Pages: 905-915
- Data Source
  KAKENHI-PROJECT-19300133
[Journal Article] Calcium loading capacity and Ca2+ buffering capacity of mitochondria after oxygen-glucose deprivation in hippocampal neurons.2009
- Author(s)
  K. Tanaka, T. Iijima, T. Mishima, K. Akagawa
- Journal Title
  
  Neurochem. Res Vol.34
  
  Pages: 221-226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300133
[Journal Article] Morphological changes in mitochomdria in an ischemic preconditioned model.2008
- Author(s)
  T. Iijima, K. Tanaka, S. Matsubara, T. Mishima, K. Akagawa
- Journal Title
  
  Neurosci. Lett vol.448
  
  Pages: 268-272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300133
[Journal Article] Transient silencing of synaptic transmitter release from specific neuronal types by recombinant tetanus toxin light chain fused to antibody variable region2008
- Author(s)
  T. Kobayashi, N. Kai, K. Kobayashi, T. Fujiwara, K. Akagawa, M. Onda, K. Kobayashi
- Journal Title
  
  J. Neurosci. Methods vol.175
  
  Pages: 125-132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300133
[Journal Article] HPC-1/syntaxin 1A gene knockout mice show abnormal behavior possibly related to a disruption in 5-HTergic systems.
- Author(s)
  T. Fujiwara, M. Sanada, T. Kofuji, T. Yoshikawa, K. Akagawa
- Journal Title
  
  Eur. J. Neurosci (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300133
[Presentation] STX1A, STX1B欠損マウスにおける行動異常の比較2013
- Author(s)
  藤原智徳、小藤剛史、三嶋竜也、赤川公朗
- Organizer
  日本神経科学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24300142
[Presentation] 神経細胞の生存に対するHPC-1/シンタキシン１Ａとシンタキシン１Ｂの異なる役割2013
- Author(s)
  小藤剛史、藤原智徳、真田ますみ、三嶋竜也、赤川公朗
- Organizer
  日本神経科学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24300142
[Presentation] 神経細胞における小胞体ストレスはＡｂ分泌の抑制とsyntaxin5を含むER-Golgi SNAREの発現量の上昇を引き起こす2013
- Author(s)
  須賀圭、斎藤綾子、赤川公朗
- Organizer
  日本神経化学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24300142
[Presentation] 広汎性発達障害とsyntaxin1A遺伝子との関連性の検討
- Author(s)
  小藤剛史、林優子、田丸政男、赤川公朗
- Organizer
  日本小児神経学会
- Place of Presentation
  浜松
- Year and Date
  2014-05-29 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-24300142
[Presentation] syntaxin1A遺伝子のＰＫＡを介した転写制御機構
- Author(s)
  中山高宏、赤川公朗
- Organizer
  日本生化学大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24300142
[Presentation] Upregulation of ER-Goligi SNARE syntaxin5 by ER stress and its relation with beta APP processing
- Author(s)
  K.Suga, A.Saito, T.Mishima & K.Akagawa
- Organizer
  日本神経化学会大会
- Place of Presentation
  奈良
- Year and Date
  2014-09-29 – 2014-10-01
- Data Source
  KAKENHI-PROJECT-24300142
[Presentation] 自閉症スペクトラム障害とHPC-1/syntaxinA遺伝子発現異常の関連性の検討
- Author(s)
  小藤剛史、林優子、藤原智徳、真田ますみ、田丸政男、赤川公朗
- Organizer
  日本神経化学会大会
- Place of Presentation
  奈良
- Year and Date
  2014-09-29 – 2014-10-01
- Data Source
  KAKENHI-PROJECT-24300142

1. FUJIWARA Tomonori (90255399)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
2. MISHIMA Tatsuya (40317095)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
3. YAMAGUCHI Kazuhiko (00191221)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. SAITOU Ayako (80424109)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. FUJINO Ichiro (30265764)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. SUGA Kei (30306675)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
7. KOFUJI Takefumi (40365200)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
8. SANADA Masumi (70424108)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
9. NAKAYAMA Takahiro (90342823)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. OSANAI Makoto (90286419)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NIRASAWA Yuji (60129591)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ITO Yasuo (80110881)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KUJI Naoaki (80169987)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YOSHIMURA Yasunori (10129736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TANAKA Hiroaki (40266565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SHIRAO Tomoaki (20171043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 九島洋一 (30255400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 田中裕之 (90271270)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 吉村和法 (20158497)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 鈴木勝 (40095378)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 植村慶一 (90049792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 田中早苗

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 堀雄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

AKAGAWA kimio 赤川 公朗

赤川 公朗 アカガワ キミオ

AKAGAWA Kimio 赤川 公朗

赤川 公郎 アカガワ キミオ

Research Projects

Research Products

Co-Researchers

Functional difference between syntaxin1 isoforms in synaptic transmissionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of syntaxin 1 gene knockout mice as an animal model for autistic disorderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Expression and role of exocytotic SNARE proteins on oocyte cortical reaction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

神経可塑性に関わる神経特異蛋白質HPC-1の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

STUDY OF A NEURON-SPECIFIC PROTEIN,HPC-1, WHICH REGULATES NEURONAL SPROUTING.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Immunohistochemical studies of abnormal extrinsic nerve fibers in Hirschsprung's disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

神経突起末端部における神経細胞膜蛋白質HPC-1の機能に関する生理学的研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

シナプス前膜蛋白質に対するアンチセンスDNA等を用いた神経伝達物質放出機構の解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

組織培養法による経シナプス性黒質神経細胞死の機序・防御の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Studies of Neuronal Properties in the Reaggregate Cultures of Rat RetinanePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 基礎医学(クルズス診療科(4))2008

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] ER stress response in NG108-15 cells involves upregulation of syntaxin 5 expression and reduced amyloid beta peptide secretion.2015

Author(s)

Journal Title

Data Source

[Journal Article] Presynaptic inhibitory actions of pregabalin on excitatory transmission in superficial dorsal horn of mouse spinal cord: further characterization of presynaptic mechanisms2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Syntaxin 1B, but Not Syntaxin 1A, is Necessary for the Regulation of Synaptic Vesicle Exocytosis and of the Readily Releasable Pool at Central Synapses2014

AKAGAWA kimio 赤川公朗

赤川公朗アカガワキミオ

AKAGAWA Kimio 赤川公朗

赤川公郎アカガワキミオ