TOMOSUGI Naohisa 友杉直久

… Alternative Names

TOMOSUGU Naohisa 友杉直久

友杉直久トモズギナオヒサ

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Researcher Number	80155580
Other IDs	https://orcid.org/0000-0001-5253-5590
Affiliation (Current)	2025: 金沢医科大学, 総合医学研究所, 教授
Affiliation (based on the past Project Information) *help	2017: 金沢医科大学, 総合医学研究所, 教授 2015: 金沢医科大学, 医学部, 教授 2015: 金沢医科大学, 総合医学研究所, 教授 2012 – 2013: 金沢医科大学, 総合医学研究所, 教授 2007 – 2011: 金沢医科大学, 付置研究所, 教授 … More 2010: 金沢医科大学, 医学部, 教授 2008: 金沢医科大学, 総合医学研究所, 教授 1999 – 2000: 金沢医科大学, 医学部, 助教授 1995: 金沢医科大学, 医学部, 講師 1993: 金沢大学, 医療技術短期大学部, 助教授 Less
Review Section/Research Field	Principal Investigator Kidney internal medicine / Kidney internal medicine Except Principal Investigator Hematology / 膠原病・アレルギー・感染症内科学 / Gastroenterology / General medical chemistry / Embryonic/Neonatal medicine
Keywords	Principal Investigator メサンギウム細胞 / renal interstitial injury / renal transplantation / acid stress / ischemic reperfusion / glomerulonephritis / macrophage migration inhibitory factor (MIF) / gene transfer / recombinant adenovirus / MIF … More / アデノウイルス / 腎間質障害 / 腎移植 / 酸化ストレス / 虚血再灌流 / 糸球体腎炎 / マクロファージ遊走阻止因子(MIF) / 遺伝子導入 / 組換えアデノウイルス / 骨髄造血由来因子 / 骨髄造血機能 / ヘプシジン-25 / メタロプロテイナーゼ-2 / 膜型メタロプロテイナーゼ / 増殖因子 / サイトカイン / in situ hybridization / 細胞外基質 / メタロプロティナーゼ … More Except Principal Investigator ヘプシジン / 鉄代謝 / 血液内科学 / フェリチン / EMT / 膵臓癌 / 鉄芽球性貧血 / ヘモクロマトーシス / GDF15 / エリスロフェロン / 無効造血 / 赤血球造血 / 血液内科 / トシリズマブ / TNFα / BMP / tocilizumab / TNFa / リウマチ / TNF-a / フェロポルチン / 関節リウマチ / IL-6 / 炎症性貧血 / RBM8A（Y14) / アポトーシス / M期 / RBM8A(Y14) / PhosTagゲル / リン酸化 / 中心体 / Y14 / Th2免疫応答 / IL-4 / 転写因子IRF-1 / アレルギー / 炎症学 / DNAマイクロアレイ / 獲得免疫 / 自然免疫 / 自己免疫性膵炎 / ミクリッツ病 / IgG4関連疾患 / IgG4 / 膠原病学 / GSK3β / 膵臓癌治療薬 / 化学療法誘導性EMT / GSK３β / 膵臓がん / ドラッグリポジショニング / 化学療法 / 鉄過剰症 / GVHD / 造血幹細胞移植 / 母乳 / 発生学 / 中枢神経 / 未熟児 / 新生児医療 / 遺伝子解析 / 遊走能 / 転移・浸潤 / GEMCITABINE / 塩酸ゲムシタビン Less

Crosstalk between erythropoiesis and iron homeostasis
- Principal Investigator
  
  KAWABATA Hiroshi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kanazawa Medical University
  Kyoto University
Analysis of novel centrosome regulation in human NSC
- Principal Investigator
  
  ISHIGAKI Yasuhito
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kanazawa Medical University
The elucidation and clinical application of the hepcidin-ferroportin regulation mechanism in inflammatory anemia
- Principal Investigator
  
  Nakazawa Soken
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
A novel function of Interferon regulatory factor-1
- Principal Investigator
  
  ASANO Yoshihiro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Institute of Physical and Chemical Research
  Kanazawa Medical University
Development of the pancreatic cancer therapy by identification of EMT inducer by chemotherapy
- Principal Investigator
  
  SHIMASAKI Takeo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa Medical University
Analysis of pathogenesis of IgG4-related disease
- Principal Investigator
  
  UMEHARA Hisanori
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kanazawa Medical University
Regulatory mechanisms of hepcidin, the central regulator of body iron homeostasis
- Principal Investigator
  
  KAWABATA Hiroshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kyoto University
The exhaustive analysis of signal transducing molecules contributing to neonatal brain development in breast milk
- Principal Investigator
  
  SIMAMURA Eriko
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Kanazawa Medical University
Regulation of hepcidin expression in renal failure-participation of erythropoiesis related factor-Principal Investigator
- Principal Investigator
  
  TOMOSUGI Naohisa
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kanazawa Medical University
Impaired Iron Metabolism in Anemia of Chronic Disease
- Principal Investigator
  
  KAWABATA Hiroshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kyoto University
塩酸ゲムシタビンによる膵がん細胞のEMT誘導の検証と分子細胞機構の解明
- Principal Investigator
  
  SHIMASAKI Takeo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa Medical University
The research on the control of glomerulonephritis by the MIF gene transfer using the recombinant adenovirus vectorPrincipal Investigator
- Principal Investigator
  
  TOMOSUGI Naohisa
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kanazawa Medical University
メサンギウム細胞における膜型メタロプロテイナーゼの発現-糸球体におけるメタロプロテイナーゼ-2の活性化機序-Principal Investigator
- Principal Investigator
  
  友杉直久
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kanazawa Medical University
メタロプロティナーゼによる糸球体メサンギウム基質の代謝調節機構Principal Investigator
- Principal Investigator
  
  友杉直久
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kanazawa University

All 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] High pretransplant hepcidin levels are associated with poor overall survival and delayed platelet engraftment after allogeneic hematopoietic stem cell transplantation.2017
- Author(s)
  Sakamoto S, Kawabata H, Kanda J, Uchiyama T, Mizumoto C, Kitano T, Kondo T, Hishizawa M, Tomosugi N, Takaori-Kondo A
- Journal Title
  
  Cancer Med
  
  Volume: 6 Issue: 1 Pages: 120-128
- DOI
  10.1002/cam4.974
- NAID
  120005997797
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461400
[Journal Article] Nonsense-mediated mRNA decay factor Upf2 exists in both the nucleoplasm and the cytoplasm.2016
- Author(s)
  Tatsuno T, Nakamura Y, Ma S, Tomosugi N, Ishigaki Y
- Journal Title
  
  Molecular Medicine Reports
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460376
[Journal Article] A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression2015
- Author(s)
  Kawabata H, Uchiyama T, Sakamoto S, Kanda J, Oishi S, Fujii N, Tomosugi N, Kadowaki N, Takaori-Kondo A
- Journal Title
  
  Experimental Hematology
  
  Volume: in press Issue: 5 Pages: 404-413.e5
- DOI
  10.1016/j.exphem.2015.01.005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461400
[Journal Article] Phosphorylation status of human RNA-binding protein 8A in cells and its inhibitory regulation by Magoh2014
- Author(s)
  Y.Ishigaki, Y.Nakamura, T.Tatsuno, S.Ma, N.Tomosugi
- Journal Title
  
  Exp. Biol. Med. (Maywood)
  
  Volume: 240 Issue: 4 Pages: 438-445
- DOI
  10.1177/1535370214556945
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460376
[Journal Article] RNA binding protein RBM8A (Y14) and MAGOH localize to centrosome in human A549.2014
- Author(s)
  Ishigaki Y, Nakamura Y, Tatsuno T, Hashimoto M, Iwabuchi K, Tomosugi N.
- Journal Title
  
  Histochem Cell Biol
  
  Volume: 141 Issue: 1 Pages: 101-109
- DOI
  10.1007/s00418-013-1135-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310041, KAKENHI-PROJECT-23510067, KAKENHI-PROJECT-24651056, KAKENHI-PROJECT-25460376
[Journal Article] Depletion of RNA-binding protein RBM8A (Y14) causes cell cycle deficiency and apoptosis in human cells.2013
- Author(s)
  Ishigaki Y, Nakamura Y, Tatsuno T, Hashimoto M, Shimasaki T, Iwabuchi K, Tomosugi N.
- Journal Title
  
  Exp Biol Med
  
  Volume: 238 Issue: 8 Pages: 889-897
- DOI
  10.1177/1535370213494646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310041, KAKENHI-PROJECT-23510067, KAKENHI-PROJECT-24651056, KAKENHI-PROJECT-25460376
[Journal Article] Comparative evaluation of the effects of treatment with tocilizumab and TNF-α inhibitors on serum hepcidin, anemia response and disease activity in rheumatoid arthritis patients2013
- Author(s)
  Soken-Nakazawa J Song, Mitsuhiro Iwahashi, Naohisa Tomosugi, Kazuko Uno, Jiro Yamana, Seizou Yamana,Tomoyasu Isobe, Hiroki Ito, Hiroshi Kawabata, Kazuyuki Yoshizaki
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 15 Issue: 5 Pages: 1-10
- DOI
  10.1186/ar4323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460784, KAKENHI-PROJECT-25461452
[Journal Article] Acidic milieu augments the expression of hepcidin, the central regulator of iron homeostasis2012
- Author(s)
  Mizumoto C, Kawabata H, Uchiyama T, Sakamoto S, Kanda J, Tomosugi N, Takaori-Kondo A
- Journal Title
  
  Int J Hematol
  
  Volume: 96 Issue: 6 Pages: 701-709
- DOI
  10.1007/s12185-012-1223-6
- NAID
  10031144608
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591033
[Journal Article] A case of congenital dyserythropoietic anemia type 1 in a japanese adult with a cdan1 gene mutation and an inappropriately low serum hepcidin-25 level.2012
- Author(s)
  Kawabata H, Doisaki S, Okamoto A, Uchiyama T, Sakamoto S, Hama A, Hosoda K, Fujikura J, Kanno H, Fujii H, Tomosugi N, Nakao K, Kojima S, Takaori-Kondo A
- Journal Title
  
  Intern Med
  
  Volume: 51 Pages: 917-920
- NAID
  130002061879
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591033
[Journal Article] A case of congenital dyserythropoietic anemia type 1 in a japanese adult with a cdan1 gene mutation and an inappropriately low serum hepcidin-25 level2012
- Author(s)
  Kawabata H, Doisaki S, Okamoto A, Uchiyama T, Sakamoto S, Hama A, Hosoda K, Fujikura J, Kanno H, Fujii H, Tomosugi N, Nakao K, Kojima S, Takaori-Kondo A
- Journal Title
  
  Intern Med
  
  Volume: 51 Pages: 917-920
- NAID
  130002061879
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591033
[Journal Article] Glycogen synthase kinase 3βinhibition sensitizes pancreatic cancer cells to gemcitabine2012
- Author(s)
  Shimasaki T, Ishigaki Y, Nakamura Y, Takata T, Nakaya N, Nakajima H, Sato I, Zhao X, Kitano A, Kawakami K, Tanaka T, Takegami T, Tomosugi N, Minamoto T, Motoo Y.
- Journal Title
  
  J Gastroenterol
  
  Volume: 47(3) Pages: 321-33
- NAID
  10030560208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591016
[Journal Article] Downregulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman's disease (MCD)2010
- Author(s)
  Song S, N., J., Tomosugi N, Kawabata H, Ishikawa T, Nishikawa, T, Yoshizaki K.
- Journal Title
  
  Blood
  
  Volume: 116 Pages: 3627-3634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591033
[Journal Article] 鉄過剰症その病態と治療ヘプシジン測定2010
- Author(s)
  友杉直久
- Journal Title
  
  日本医師会雑誌
  
  Volume: 139 Pages: 290-290
- Data Source
  KAKENHI-PROJECT-20590966
[Journal Article] 鉄代謝の臨床鉄欠乏と鉄過剰診断と治療の進歩-ヘプシジンの発見とその後の発展-2010
- Author(s)
  友杉直久
- Journal Title
  
  日本内科学会雑誌
  
  Volume: 99 Pages: 1180-1187
- Data Source
  KAKENHI-PROJECT-20590966
[Journal Article] Tocilizumab, a humanized anti-interleukin-6 receptor antibody, improved anemia in monkey arthritis by suppressing IL-6-induced hepcidin production.2010
- Author(s)
  Hashizume M, Uchiyama Y, Horai N, Tomosugi N, Mihara M.
- Journal Title
  
  Rheumatol Int. 30
  
  Pages: 917-923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590966
[Journal Article] Downregulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman's disease (MCD).2010
- Author(s)
  Song SN, Tomosugi N, Kawabata H, Ishikawa T, Nishikawa T, Yoshizaki K.
- Journal Title
  
  Blood. 116(18)
  
  Pages: 3627-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590966
[Journal Article] Downregulation of hepcidin resulting from long-term treatment with an anti-il-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric castleman's disease (mcd)2010
- Author(s)
  Song S, N., J., Tomosugi N, Kawabata H, Ishikawa T, Nishikawa T, Yoshizaki K
- Journal Title
  
  Blood
  
  Volume: 116 Issue: 18 Pages: 3627-3634
- DOI
  10.1182/blood-2010-03-271791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591033
[Journal Article] Biological effects of mutant ceruloplasmin on hepcidin-mediated internalization of ferroportin.2010
- Author(s)
  Kono S, Yoshida K, Tomosugi N, Terada T, Hamaya Y, Kanaoka S, Miyajima H.
- Journal Title
  
  Biochim Biophys Acta. 1802(11)
  
  Pages: 968-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590966
[Journal Article] Measurement of serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders.2010
- Author(s)
  Kaneko Y, Miyajima H, Piperno A, Tomosugi N, Hayashi H, Morotomi N, Tsuchida KI, Ikeda T, Ishikawa A, Ota Y, Wakusawa S, Yoshioka K, Kono S, Pelucchi S, Hattori A, Tatsumi Y, Okada T, Yamagishi M.
- Journal Title
  
  J Gastroenterol. 45(11)
  
  Pages: 1163-71
- NAID
  10027699891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590966
[Journal Article] Patients with chronic hepatitis C may be more sensitive to iron hepatotoxicity than patients with HFE-hemochromatosis.2010
- Author(s)
  Hayashi H, Piperno A, Tomosugi N, Hayashi K, Kimura F, Wakusawa S, Yano M, Tatsumi Y, Hattori A, Pelucchi S, Katano Y, Goto H.
- Journal Title
  
  Intern Med. 49(22)
  
  Pages: 2371-7
- NAID
  130000413363
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590966
[Journal Article] Increased Hepcidin Production Impairs Iron Metabolism after Pancreatoduodenectomy.2010
- Author(s)
  Kosuge T, Sawada T, Shimoda M, Kita J, Tomosugi N, Kubota K.
- Journal Title
  
  World J Surg. 34(10)
  
  Pages: 2452-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590966
[Journal Article] Oncostatin M and leukemia inhibitory factor increase hepcidin expression in hepatoma cell lines.2009
- Author(s)
  Kanda J, Uchiyama T, Tomosugi N, Higuchi M, Uchiyama T, Kawabata H.
- Journal Title
  
  Int J Hematol. 90
  
  Pages: 545-552
- NAID
  10026109746
- Data Source
  KAKENHI-PROJECT-20590966
[Journal Article] Results of the first international round robin for the quantification of urinary and plasma hepcidin assays : need for standardization.2009
- Author(s)
  Kroot JJ, Kemna EH, Bansal SS, Busbridge M, Campostrini N, Girelli D, Hider RC, Koliaraki V, Mamalaki A, Olbina G, Tomosugi N, Tselepis C, Ward DG, Ganz T, Hendriks JC, Swinkels DW.
- Journal Title
  
  Haematologica. 94
  
  Pages: 1748-1752
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590966
[Journal Article] Serum hepcidin level and erythropoietic activity after haematopoietic stem cell transplantation2008
- Author(s)
  Kanda J, Mizumoto C, Kawabata H, Tsuchida H, Tomosugi N, Matsuo K and Uchiyama T.
- Journal Title
  
  Haematologica 93
  
  Pages: 1550-4
- Data Source
  KAKENHI-PROJECT-19591107
[Journal Article] Serum hepcidin level and erythropoietic activity after hematopoietic stem cell transplantation.2008
- Author(s)
  Kanda J, Mizumoto C, Kawabata H, Tsuchida H, Tomosugi N, Matsuo K, Uchiyama T.
- Journal Title
  
  Haematologica. 93(10)
  
  Pages: 1550-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590966
[Journal Article] Patients with chronic hepatitis C achieving a sustained virological response to peginterferon and ribavirin therapy recover from impaired hepcidin secretion.2008
- Author(s)
  Fujita N, Sugimoto R, Motonishi S, Tomosugi N, Tanaka H, Takeo M, Iwasa M, Kobayashi Y, Hayashi H, Kaito M, Takei Y.
- Journal Title
  
  J Hepatol. 49(5)
  
  Pages: 702-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590966
[Journal Article] Serum hepcidin level and erythropoietic activity after haematopoietic stem cell transplantation2008
- Author(s)
  Kanda J. Mizumoto C, Kawabata H, Tsuchida H, Tomosugi N, Matsuo K, Uchiyama T
- Journal Title
  
  Haematologica 93
  
  Pages: 1550-1554
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591107
[Journal Article] Anti-interleukin 6 receptor antibody tocilizumab reduces the level of serum hepcidin in patients with multicentric Castleman's disease.2007
- Author(s)
  Kawabata H, Tomosugi N, Kanda J, Tanaka Y, Yoshizaki K and UchiyamaT.
- Journal Title
  
  HAEMATOLOGICA 92
  
  Pages: 857-858
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591107
[Journal Article] Anti-interleukin 6 receptor antibody tocilizumab reduces the level of serum hepcidin in patients with multicentric Castleman's disease2007
- Author(s)
  Kawabata H, Tomosugi N, Kanda J, Tanaka Y, Yoshizaki K and Uchiyama T.
- Journal Title
  
  Haematologica 92
  
  Pages: 857-8
- Data Source
  KAKENHI-PROJECT-19591107
[Journal Article] Clinical Significance of Serum Hepcidin Levels on Early Infectious Complications in Allogeneic Hematopoietic Stem Cell Transplantation
- Author(s)
  Kanda J, Mizumoto C, Kawabata H, Ichinohe T, Tsuchida H, Tomosugi N, Matsuo K, Yamashita K, Kondo T, Ishikawa T and Uchiyama T.
- Journal Title
  
  Biol Blood Marrow Transplant (in press)
- NAID
  120001462496
- Data Source
  KAKENHI-PROJECT-19591107
[Presentation] Phase I clinical trial of the combination therapy using gemcitabine and GSK3beta inhibiting drugs for gemcitabine-resistant advanced pancreatic cancer patients2014
- Author(s)
  Shimasaki T, Tomosugi N, Minamoto T, et al.
- Organizer
  DDW 2014
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-23591016
[Presentation] GSK3βを標的治療とした既存医薬品による膵がんの新規治療2013
- Author(s)
  島崎猛夫,石垣靖人,源利成,友杉直久他
- Organizer
  第44回日本膵臓学会大会
- Place of Presentation
  仙台国際センター
- Data Source
  KAKENHI-PROJECT-23591016
[Presentation] 細胞内mRNA-タンパク質構造の可視化2013
- Author(s)
  石垣靖人, 中村有香, 辰野貴則, 島田ひろき, 八田稔久, 桑畑　進, 中川秀昭, 竹上　勉, 友杉直久
- Organizer
  日本顕微鏡学会　第69回学術講演会
- Place of Presentation
  大阪府吹田市　ホテル阪急エキスポパーク
- Data Source
  KAKENHI-PROJECT-25460376
[Presentation] GSK3βis an emerging therapeutic target in pancreatic cancer : its implication for cancer cell migration and invasion2013
- Author(s)
  Shimasaki T, Ishigaki Y, Tomosugi N, Minamoto T, et al.
- Organizer
  DDW 2013
- Place of Presentation
  Orland, FL, USA
- Data Source
  KAKENHI-PROJECT-23591016
[Presentation] 中心体局在因子RBM8Aのリン酸化制御の解析2013
- Author(s)
  石垣靖人, 中村有香, 辰野貴則, 馬　少幅, 中川秀昭, 竹上　勉, 友杉直久
- Organizer
  第65回日本細胞生物学会大会
- Place of Presentation
  愛知県名古屋市　ウインクあいち
- Data Source
  KAKENHI-PROJECT-25460376
[Presentation] 血液疾患における GDF15 と鉄代謝異常(シンポジウム講演)2012
- Author(s)
  内山達樹, 川端浩, 友杉直久, 高折晃史
- Organizer
  第36回日本鉄バイオサイエンス学会学術集会
- Place of Presentation
  京王プラザホテル札幌・札幌市
- Year and Date
  2012-09-02
- Data Source
  KAKENHI-PROJECT-22591033
[Presentation] GSK3β標的治療を併用した膵癌の新規治療戦略と分子基盤2012
- Author(s)
  島崎猛夫,石垣靖人,源利成,友杉直久他
- Organizer
  第20回JDDW
- Place of Presentation
  神戸国際展示場・ポートピアホテル・神戸こうくさい会議場
- Data Source
  KAKENHI-PROJECT-23591016
[Presentation] 膵癌の新規治療標的としてのglycogen synthase kinase (GSK) 3β:がん浸潤に対する作用2012
- Author(s)
  島崎猛夫,石垣靖人,源利成,友杉直久他
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PROJECT-23591016
[Presentation] GSK3β標的治療と化学療法を併用する膵がんの新規治療戦略と分子基盤2012
- Author(s)
  島崎猛夫,石垣靖人,源利成,友杉直久他
- Organizer
  第43回日本膵臓学会大会
- Place of Presentation
  ホテルメトロポリタン山形
- Data Source
  KAKENHI-PROJECT-23591016
[Presentation] 種々の血液疾患における血清GDF15値(Serum levels of GDF15 in various hematological disorders)2011
- Author(s)
  Uchiyama Tatsuki, Kawabata Hiroshi, Kanda Junya, Tomosugi Naohisa, Sakamoto Soichiro, Mizumoto Chisaki, Takaori-Kondo Akifumi
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋国際会議場・名古屋市・愛知県
- Data Source
  KAKENHI-PROJECT-22591033
[Presentation] Impact of pre-transplant hepcidin-25 in patients undergoing allo-SCT for hematologic malignancies造血器腫瘍に対する同種造血幹細胞移植における移植前ヘプシジン値の影響2011
- Author(s)
  Soichiro Sakamoto, Hiroshi Kawabata, Junya Kanda, Tatsuki Uchiyama, Chisaki Mizumoto, Tadakazu Kondo, Kouhei Yamashita, Tatsuo Ichinohe, Takayuki Ishikawa, Norimitsu Kadowaki, Naohisa Tomosugi, Akifumi Takaori-Kondo
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋国際会議場・名古屋市・愛知県
- Data Source
  KAKENHI-PROJECT-22591033
[Presentation] 種々の血液疾患における血清 GDF15 値(Serum levels of GDF15 in various hematological disorders)2011
- Author(s)
  Uchiyama Tatsuki, Kawabata Hiroshi, Kanda Junya, Tomosugi Naohisa, Sakamoto Soichiro, Mizumoto Chisaki, Takaori-Kondo Akifumi
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋国際会議場・名古屋市・愛知県
- Data Source
  KAKENHI-PROJECT-22591033
[Presentation] Impact of pre-transplant hepcidin-25 in patients undergoing allo-SCT for hematologic malignancies(造血器腫瘍に対する同種造血幹細胞移植における移植前ヘプシジン値の影響)2011
- Author(s)
  Soichiro Sakamoto, Hiroshi Kawabata, Junya Kanda, Tatsuki Uchiyama, Chisaki Mizumoto, Tadakazu Kondo, Kouhei Yamashita, Tatsuo Ichinohe, Takayuki Ishikawa, Norimitsu Kadowaki, Naohisa Tomosugiand Akifumi Takaori-Kondo
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋国際会議場・名古屋市・愛知県
- Data Source
  KAKENHI-PROJECT-22591033
[Presentation] キャッスルマン病と炎症性貧血2011
- Author(s)
  川端浩, 諫田淳也, 上田恭典, 友杉直久, 高折晃史
- Organizer
  第35回日本鉄バイオサイエンス学会学術集会
- Place of Presentation
  徳島文理大学・徳島市・徳島県
- Data Source
  KAKENHI-PROJECT-22591033
[Presentation] PROGNOSTIC IMPACT OF PRE-TRANSPLANT SERUM HEPCIDIN LEVELS ON CLINICAL OUTCOMES AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION2011
- Author(s)
  Soichiro Sakamoto, Hiroshi Kawabata, Junya Kanda, Tatsuki Uchiyama, Chisaki Mizumoto, Tadakazu Kondo, Kouhei Yamashita, Tatsuo Ichinohe, Takayuki Ishikawa, Norimitsu Kadowaki, Naohisa Tomosugi and Akifumi Takaori-Kondo
- Organizer
  16th Congress of the European Hematology Association
- Place of Presentation
  Excel, London, United Kingdom
- Data Source
  KAKENHI-PROJECT-22591033
[Presentation] キャッスルマン病と炎症性貧血2011
- Author(s)
  川端浩, 諫田淳也, 上田恭典, 友杉直久, 高折晃史
- Organizer
  第35回日本鉄バイオサイエンス学会学術集会
- Place of Presentation
  徳島文理大学・徳島市
- Data Source
  KAKENHI-PROJECT-22591033
[Presentation] 腎性貧血ガイドライン達成を目指す貧血管理ヘプシジン-25による新しい観点2010
- Author(s)
  友杉直久
- Organizer
  第55回日本透析医学会学術集会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-20590966
[Presentation] ラット初乳中の蛋白,ペプチド成分のプロファイリング2010
- Author(s)
  島田ひろき, 島村英理子, 内芝舞実, 東伸明, 増田浩子, 高田尊信, 土田秀行, 石垣靖人, 友杉直久, 八田稔久
- Organizer
  第50回日本先天異常学会学術集会
- Place of Presentation
  淡路島
- Year and Date
  2010-07-08
- Data Source
  KAKENHI-PROJECT-21791045
[Presentation] 腎性貧血ガイドライン達成を目指す貧血管理ヘプシジン-25による新しい観点2010
- Author(s)
  友杉直久
- Organizer
  第54回日本透析医学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-20590966
[Presentation] 保存期CKD患者における腎性貧血に与える血清インドキシル硫酸の影響の横断的検討2010
- Author(s)
  勝二達也,友杉直久,植畑拓也,川端裕彰,新畑覚也,坂口悠介,下村明弘,鈴木朗,金子哲也,椿原美治
- Organizer
  第53回日本腎臓学会学術総会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-20590966
[Presentation] 透析患者における貧血発症メカニズムと病態ヘプシジン-25と骨髄造血機能2009
- Author(s)
  友杉直久
- Organizer
  第54回日本透析医学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590966
[Presentation] TfR2-related hereditary hemochro-matosis in Japan.2009
- Author(s)
  Mizumoto C, Kanda J, Kawabata H, Uchiyama T, Kojima K, Hayashi T, Hirata M, Nakao K, Tsuchida K, Kawanaka M, Yamada G, Tomosugi N, Tatsumi Y, Hattori A, Hayashi H.
- Organizer
  2009 International Biolron Society
- Place of Presentation
  Porto, Portugal
- Data Source
  KAKENHI-PROJECT-20590966
[Presentation] Hepcidin-22 produced in urinary space2009
- Author(s)
  Tomosugi N
- Organizer
  The 10th International Symposium on Sjogren's Syndrome
- Place of Presentation
  ブレスト(フランス)
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20590966
[Presentation] Cause of Iron Overload-Hepcidin2009
- Author(s)
  Kawabata H and Tomosugi N.
- Organizer
  5th General Assembly of Asian Hematology Association-2009
- Place of Presentation
  Kobe, (Symposium)
- Year and Date
  2009-02-19
- Data Source
  KAKENHI-PROJECT-19591107
[Presentation] Elevation of serum hepcidin 25 levels is well correlated with the progression of renal anemia in the peritoneal dialysis patients.2009
- Author(s)
  Okubo K, Higuchi M, Kamijo Y, Nagasawa M, Tamura K, Tomosugi N
- Organizer
  ASN Renal Week 2009
- Place of Presentation
  San Diego, CA
- Data Source
  KAKENHI-PROJECT-20590966
[Presentation] Cause of Iron Overload-Hepcidin2009
- Author(s)
  Kawabata H, Tomosugi N
- Organizer
  5th General Assembly of Asian Hematology Association-2009
- Place of Presentation
  神戸
- Year and Date
  2009-02-13
- Data Source
  KAKENHI-PROJECT-19591107
[Presentation] Hepcidin-22 produced in urinary space2009
- Author(s)
  Tomosugi N
- Organizer
  The 8th HUPO World Congress
- Place of Presentation
  トロント(カナダ)
- Year and Date
  2009-09-28
- Data Source
  KAKENHI-PROJECT-20590966
[Presentation] シンポジウム12 透析患者における貧血-発症メカニズムと病態-ヘプシジン-25と骨髄造血機能2009
- Author(s)
  友杉直久
- Organizer
  第54回日本透析医学会学術集会
- Place of Presentation
  横浜(パシフィコ横浜)
- Year and Date
  2009-06-07
- Data Source
  KAKENHI-PROJECT-20590966
[Presentation] 造血幹細胞移植における血清ヘプシジン値と造血能2008
- Author(s)
  諫田淳也、水本智咲、川端浩、内山卓、土田秀行、友杉直久、松尾恵太郎
- Organizer
  第32回日本鉄バイオサイエンス学会学術集会
- Place of Presentation
  ホテルアラスカ(青森市)
- Data Source
  KAKENHI-PROJECT-19591107
[Presentation] 保存期腎不全患者におけるヘプシジンの検討2008
- Author(s)
  植畑拓也、友杉直久,坂口悠介,下村明弘,井上和則,金子哲也,勝二達也,岡田倫之,椿原美治
- Organizer
  第51回日本腎臓学会学術総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-20590966
[Presentation] Identification and quantification of tear proteins in Sjogren's syndrome.2008
- Author(s)
  Tomosugi N, H.Tuchida, M.Higuchi, H.Sasaki, K.Kitagawa.
- Organizer
  HUP02008 7th World Congeress
- Place of Presentation
  Amsterdam, NL
- Data Source
  KAKENHI-PROJECT-20590966
[Presentation] Clinical Significance of Serum Hepcidin-25 Levels on Early Treatment-Related Complications after Hematopoietic Stem Cell Transplantation2008
- Author(s)
  Junya Kanda, Chisaki Mizumoto, Hiroshi Kawabata, Tatsuo Ichinohe, Hideyuki Tsuchida, Tomosugi N, Keitaro Matsuo, Tadakazu Kondo, Takayuki Ishikawa, Takashi Uchiyama.
- Organizer
  50^<th> ASH Annual Meeting
- Place of Presentation
  San Francisco, CA
- Data Source
  KAKENHI-PROJECT-20590966
[Presentation] Results of the First International Round Robin for the Quantification of Urinary and Plasma Hepcidin : Need for Standardization2008
- Author(s)
  Joyce JC Kroot, Erwin HJM Kemna, Sukhvinder Bansal, Mark Busbridge, Vatascia Campostrini, Domenico Girelli, Robert C Hider, Vasiliki Koliaraki, Avgi Mamalaki, Gordana Olbina, Naohisa Tomosugi, Chris Tselepis, Douglas G Ward, Tomas Ganz, Jan CM Hendriks, Dorine W. Swinkels.
- Organizer
  50^<th> ASH Annual Meeting
- Place of Presentation
  San Francisco, CA
- Data Source
  KAKENHI-PROJECT-20590966
[Presentation] Clinical significance of serum hepcidin-25 levels on early treatment related complications after hematopoietic stem cell transplantation2008
- Author(s)
  Kanda J, Mizumoto C, Kawabata H, Ichinohe T, Tsuchida H, Tomosugi N, Matsuo K, Kondo T, Ishikawa T, Uchiyama T
- Organizer
  50th American Society of Hematology Annual Meeting and Exposition
- Place of Presentation
  米国・サンフランシスコ
- Year and Date
  2008-12-07
- Data Source
  KAKENHI-PROJECT-19591107
[Presentation] 造血幹細胞移植における血清ヘプシジン値と造血能2008
- Author(s)
  諌田淳也, 水本智咲, 川端浩, 内山卓, 土田秀行, 友杉直久, 松尾恵太郎
- Organizer
  第32回日本鉄バイオサイエンス学会学術集会
- Place of Presentation
  青森市
- Year and Date
  2008-09-14
- Data Source
  KAKENHI-PROJECT-19591107
[Presentation] Clinical significance of serum hepcidin-25 levels on early treatment-related complications after hematopoietic stem cell transplantation2008
- Author(s)
  Kanda J, Mizumoto C, Kawabata H, Ichinohe T, Tsuchida H, Tomosugi N, Matsuo K, Kondol T, Ishikawa T and Uchiyama T.
- Organizer
  50th American Society of Hematology Annual Meeting and Exposition
- Place of Presentation
  San Francisco, CA (Poster)
- Data Source
  KAKENHI-PROJECT-19591107
[Presentation] C型慢性肝炎にみられる鉄過剰状態へのhepcidinの関与2008
- Author(s)
  藤田尚己,杉本龍亮,本西哲,田中淳一朗,別府徹也,浦和尚史,田中秀明,山本憲彦,小林由直,岩佐元雄,白木克哉,友杉直久,林久男,竹井謙之
- Organizer
  第94回日本消化器病学会総会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-20590966
[Presentation] Serum Level of Hepcidin and Erythropoietic Activity after Hematopoietic Stem Cell Transplantation.2007
- Author(s)
  Kanda J, Mizumoto C, Kawabata H, Tsuchida H, Tomosugi N, Uchiyama T
- Organizer
  49th Annual Meeting of the American Society of Hematology
- Place of Presentation
  Atranta, Georgia, USA
- Year and Date
  2007-12-10
- Data Source
  KAKENHI-PROJECT-19591107
[Presentation] ANTI-INTERLEUKIN 6 RECEPTOR ANTIBODY TOCILIZUMAB REDUCES THE LEVELS OF SERUM HEPCIDIN IN PATIENTS WITH MULTICENTRICCASTLEMAN'S DISEASE2007
- Author(s)
  Kawabata H, Tomosugi N, Kanda J, Tanaka Y, Kadowaki N, Ichinohe T, Ishikawa T and Uchiyama T.
- Organizer
  International BioIron Society Meeting 2007
- Place of Presentation
  Kyoto Japan, (Oral presentation)
- Year and Date
  2007-04-04
- Data Source
  KAKENHI-PROJECT-19591107
[Presentation] Serum Level of Hepcidin and Erythropoietic Activity after Hematopoietic Stem Cell Transplantation2007
- Author(s)
  Kanda J, Mizumoto C, Kawabata H, Tsuchida H, Tomosugi N, Uchiyama T.
- Organizer
  49th Annual Meeting of the American Society of Hematology
- Place of Presentation
  Atranta, Georgia, USA, (Poster)
- Data Source
  KAKENHI-PROJECT-19591107
[Presentation] THE SERUM LEVEL OF HEPCIDIN AFTER STEM CELL TRANSPLANTATION2007
- Author(s)
  Kanda J, Mizumoto C, Kawabata H, Tomosugi N and Uchiyama T.
- Organizer
  International BioIron Society Meeting 2007
- Place of Presentation
  Kyoto Japan, (Poster)
- Year and Date
  2007-04-04
- Data Source
  KAKENHI-PROJECT-19591107
[Presentation] Monitoring Of Serum Hepcidin-25 In Multicentric Castleman s Disease Patients Treated With Tocilizumab, An Anti-Interleukin-6 Receptor Antibody2007
- Author(s)
  Kawabata H, Tomosugi N, Kanda J, Mizumoto C, Tanaka Y, Ichinohe T, Kadowaki N, Ishikawa T, Yoshizaki K and Uchiyama T.
- Organizer
  49th Annual Meeting of the American Society of Hematology
- Place of Presentation
  Atranta, Georgia, USA
- Year and Date
  2007-12-10
- Data Source
  KAKENHI-PROJECT-19591107
[Presentation] Monitoring Of Serum Hepcidin-25 In Multicentric Castleman s Disease Patients Treated With Tocilizumab, An Anti-Interleukin-6 Receptor Antibody2007
- Author(s)
  Kawabata H, Tomosugi N, Kanda J, Mizumoto C, Tanaka Y, Ichinohe T, IKadowaki N, Ishikawa T, Yoshizaki K, Uchiyama T.
- Organizer
  49th Annual Meeting of the American Society of Hematology
- Place of Presentation
  Atranta, Georgia, USA, (Poster)
- Data Source
  KAKENHI-PROJECT-19591107
[Presentation] Role of RNA binding protein in cell cycle progression and centrosome maturation in human tumor cells
- Author(s)
  石垣靖人, 中村有香, 辰野貴則, 橋本光正, 島崎猛夫, 岩淵邦芳, 友杉直久
- Organizer
  19th World Congress on Advances in Oncology & 17th International Symposium of Molecular Medicine
- Place of Presentation
  アテネ（ギリシャ）
- Year and Date
  2014-10-09 – 2014-10-11
- Data Source
  KAKENHI-PROJECT-25460376
[Presentation] 血液疾患におけるGDF15と鉄代謝異常（シンポジウム講演）
- Author(s)
  内山達樹, 川端浩, 友杉直久, 高折晃史
- Organizer
  第３６回日本鉄バイオサイエンス学会学術集会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-22591033

1. ISHIGAKI Yasuhito (20232275)

# of Collaborated Projects: 5 results

# of Collaborated Products: 14 results
2. KAWABATA Hiroshi (10329401)

# of Collaborated Projects: 4 results

# of Collaborated Products: 33 results
3. MORI Kiyoshi (60343232)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. MINAMOTO Toshinari (50239323)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
5. SHIMASAKI Takeo (50377420)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
6. MOTOO Yoshiharu (80210095)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. SIMAMURA Eriko (00267741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. HATTA Toshihisa (20238025)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. UMEHARA Hisanori (70247881)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TAKEGAMI Tsutomu (10113490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. FUKUSHIMA Toshihiro (60251998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MASAKI Yasufumi (40238895)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KAWANAMI Takafumi (20350762)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. FUJITA Yoshimasa (70450880)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. SAWAKI Toshioki (90534694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SAKAI Tomoyuki (90566902)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. ASANO Yoshihiro (70114353)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. MARUYAMA Saho (10301326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. NAKAMURA Yuka (00565632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
20. Nakazawa Soken (00535958)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. Yoshizaki Kazuyuki (90144485)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. Uno Kazuko (50211082)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. Ito Hiroki (60590635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. TANIGAWA Miki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. MASUDA Taro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. OISHI Shinya

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
27. SAKAMATO Soichoro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. UCHIYAMA Tatsuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
29. IWABUCHI Kuniyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
30. 橋本光正

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

TOMOSUGI Naohisa 友杉 直久

TOMOSUGU Naohisa 友杉 直久

友杉 直久 トモズギ ナオヒサ

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Regulation of hepcidin expression in renal failure-participation of erythropoiesis related factor-Principal Investigator

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The research on the control of glomerulonephritis by the MIF gene transfer using the recombinant adenovirus vectorPrincipal Investigator

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メサンギウム細胞における膜型メタロプロテイナーゼの発現-糸球体におけるメタロプロテイナーゼ-2の活性化機序-Principal Investigator

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メタロプロティナーゼによる糸球体メサンギウム基質の代謝調節機構Principal Investigator

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Research Field

Research Institution

TOMOSUGI Naohisa 友杉直久

TOMOSUGU Naohisa 友杉直久

友杉直久トモズギナオヒサ