HARADA shigeharu 原田繁春

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HARADA Shigeharu 原田繁春

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Researcher Number	80156504
Other IDs
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Affiliation (based on the past Project Information) *help	2016 – 2017: 京都工芸繊維大学, 工芸科学研究科, 教授 2015: 京都工芸繊維大学, 大学院工芸科学研究科, 教授 2011 – 2014: 京都工芸繊維大学, 工芸科学研究科, 教授 2006 – 2008: 京都工芸繊維大学, 工芸科学研究科, 教授 2003 – 2005: 京都工芸繊維大学, 繊維学部, 教授 … More 1997 – 2002: 東京大学, 大学院・薬学系研究科, 助教授 1999: Graduate School of Pharmaceutical Sciences, University of Tokyo, Associate Professor, 大学院・薬学部研究科, 助教授 1994 – 1997: Univ.of Tokyo, Dept.of Pharmaceutical Technochemistry, 薬学部, 助教授 1991 – 1993: 大阪大学, 工学部, 講師 1991 – 1992: 大阪大学, 工学部, 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Structural biochemistry / Physical pharmacy / Biophysics / 医薬分子機能学 Except Principal Investigator 寄生虫学(含医用動物学) / Functional biochemistry / Parasitology (including sanitary zoology) / Tumor biology / Bioorganic chemistry … More / 工業物理化学 / 結晶学 / Parasitology (including Sanitary zoology) / Biological Sciences Less
Keywords	Principal Investigator X線結晶構造解析 / ラウエ法 / 金属プロテアーゼ / 構造生物学 / Streptomyces caespitosus / 酵素反応機構 / ミトコンドリア電子伝達系 / 蛋白質 / 生体分子 / 結晶化 … More / 膜蛋白質 / 複合体II / 膜蛋白質の可溶化 / 電子伝達 / 膜蛋白質の結晶化 / コハク酸ユビキノン酸化還元酵素複合体 / シンクロトロン放射光 / 亜鉛プロテアーゼ / フローセル / 構造・機能相関 / 放射光 / X-ray structure analysis / elpntrnn transfpr system / fiat-mate rpduntacp / キノール酸化酵素 / 寄生虫蛋白質 / フマル酸還元酵素 / activation of water / hydrgogen bond / nucleophic attack / enzymatic reaction / structural biology / N-acetylmuramidase / zinc protease / dynamical structure / カルシウム結合蛋白質 / 時間分割構造解析 / 白色X線 / 水の活性化 / 水素結合 / 求核攻撃 / N-アセチルムラミダーゼ / 動的構造解析 / X-ray crystal structure analysis / metalloprotease / protease / Streptomayces caespitosus / プロテアーゼ / 酸素 / スナップショット構造 / 時分割X線解析 / タンパク質 / PLP酵素 / 超分子複合体 / 酵素 / 生物物理 / 電子伝達系 / 界面活性剤 / 触媒機構 / X線解析 / シンクロトロン放射法 / pHジャンプ法 / 反応機構 / 時間分析構造解析 / X線構造解析 … More Except Principal Investigator 複合体II / ミトコンドリア / 低酸素適応 / 呼吸鎖 / 結晶構造解析 / 結晶化 / 銅蛋白質 / 結晶構造 / RuBisCo / NADH-フマル酸還元系 / Ascaris suum / ロドキノン / フマル酸還元酵素 / 回虫 / 金属酵素 / 金属蛋白質 / 薬剤標的分子 / フラボプロテイン / 酵素の触媒機構 / ユビキノン / 基質結合部位 / 阻害剤 / 共結晶 / X線結晶構造解析 / ユビキノン結合部位 / NADH dehydrogenase / シアン耐酸化酵素 / 生合成 / アスコフラノン / トリパノソーマ / シアン耐性酸化酵素 / ケミカルバイオロジー / 新規薬剤標的 / ピリミジン生合成経路 / フマル酸呼吸 / 癌微小環境 / biosynthesis of ubiquinone / adaptation to low oxygen tension / crystal structure analysis / parasite / NADH-fumarate reductase / complex II / mitochondria / HIF-1 / NADH-フアル酸還元系 / ユビキノン生合成 / 結晶解析 / 寄生虫 / expression in E.coli / curculin dimer / expression in yeast / miraculin cDNA / マビンリンcDNA / クルクリンcDNA / 大腸菌における発現 / クルクリン二量体 / 酵母における発現 / ミラクリンcDNA / reflection-intensity-measurement / phosphoenolpyrubicacidcarboxylase (PEPC) / 2.0 A resolution / spinach / CO_2-fixation enzymes / X-ray structure analysis / リブロースビスリン酸カルボキシラーゼ / 二酸化炭素固定 / 反射強度測定 / ホスホエノールピルビン酸カルボキシラーゼ(PEPC) / 2.0A分解能 / ホウレンソウ / 二酸化炭素固定化酵素 / X線構造解析 / molecular replacement / crystal structure / cellobiohydrolase / beta-galactosidase / malto-pentaose(G5) forming amylase / malto-tetraose(G4) forming amylase / lysozyme / alpha-amylase / ガラクトシダ-ゼ / リポアミドデヒドロゲナ-ゼ / マルトペンタノ-ス生成酵素 / リゾチ-ム / キシラナ-ゼ / アミラ-ゼインヒビタ- / アミラ-ゼ / セルラーゼ / アミラーゼインヒビター / 分子置換法 / セロビオヒドロラーゼ / ガラクトシダーゼ / G5アミラーゼ / G4アミラーゼ / リゾチーム / αアミラーゼ / 酸素適応 / 立体構造解析 / 複合体I / コハク酸脱水酵素 / 薬剤開発 / マラリア / 電子伝達 / ブルー銅蛋白質 / シュードアズリン / アズリン / 構造解析ラボシステム / ヘム蛋白質 Less

Study on the reaction mechanism of type II NADH dehydrogenase by structural and biochemical analyses of the enzyme-inhibitor interaction.
- Principal Investigator
  
  Yamashita Tetsuo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kagawa University
Pyrimidine biosynthesis and energy metabolism in cancer microenvironment
- Principal Investigator
  
  INAOKA KEN DANIEL
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  The University of Tokyo
Chemical biology of cyanide-insensitive Trypanosome alternative oxidase.
- Principal Investigator
  
  KITA Kiyoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Parasitology (including sanitary zoology)
- Research Institution
  Nagasaki University
  The University of Tokyo
Structural characterization of reaction pathway in a PLP-enzyme, methionine gamma-lyase: crystallographic snapshots of key intermediatesPrincipal Investigator
- Principal Investigator
  
  HARADA shigeharu
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto Institute of Technology
ウシ心筋ミトコンドリア電子伝達系に存在する膜蛋白質会合体の構造研究Principal Investigator
- Principal Investigator
  
  原田繁春
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto Institute of Technology
Studies on the structure and function relationship offumarate redudase from adut Ascais suumPrincipal Investigator
- Principal Investigator
  
  HARADA Shigeharu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto Institute of Technology
低酸素適応における寄生虫ミトコンドリア特異的呼吸酵素群の生理機能
- Principal Investigator
  
  北潔
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Parasitology (including Sanitary zoology)
- Research Institution
  The University of Tokyo
膜結合性コハク酸ユビキノン酸化還元酵素複合体のX線結晶解析Principal Investigator
- Principal Investigator
  
  原田繁春
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto Institute of Technology
膜結合性コハク酸ユビキノン酸化還元酵素複合体のX線構造解析Principal Investigator
- Principal Investigator
  
  原田繁春
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
マラリア原虫ミトコンドリア特異的呼吸酵素群の分子構築と生理機能
- Principal Investigator
  
  KITA Kiyoshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
低酸素適応における回虫ミトコンドリア特異的呼吸酵素群の生理機能
- Principal Investigator
  
  北潔
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  寄生虫学(含医用動物学)
- Research Institution
  The University of Tokyo
Physiological function of respiratory enzymes specific for parasite mitochondria in the adaptation to low oxygen tension
- Principal Investigator
  
  KITA Kiyoshi
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  寄生虫学(含医用動物学)
- Research Institution
  The University of Tokyo
大腸菌の膜結合性コハク酸ユビキノン酸化還元酵素複合体のX線構造解析Principal Investigator
- Principal Investigator
  
  原田繁春
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Time-resolved X-ray Crystal Structure Analysis of ProteinPrincipal Investigator
- Principal Investigator
  
  HARADA Shigeharu
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokyo
放射光を利用した時間分割ラウエ法による酵素反応過程追跡実験法とトリガーの開発Principal Investigator
- Principal Investigator
  
  原田繁春
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
結晶構造をもとにした金属プロテアーゼ中の亜鉛による基質の活性化に関する研究Principal Investigator
- Principal Investigator
  
  原田繁春
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
ELUCIDATION OF ACTIVE CENTER AND STEREO CHEMICAL STRUCTURE OF SWEET AND SWEET-INDUCED PROTEINS BY GENE TECHNIQUE AND X'RAY ANALYSIS
- Principal Investigator
  
  KURIHARA Yoshie
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  YOKOHAMA NATIONAL UNIVERSITY
放射光を利用した時間分割ラウエ法による酵素反応過程追跡実験法とトリガーの開発Principal Investigator
- Principal Investigator
  
  原田繁春
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Zn-金属プロテアーゼの立体構造と構造・機能相関に関する研究Principal Investigator
- Principal Investigator
  
  原田繁春
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokyo
放射光を利用した時間分割ラウエ法による酵素反応過程追跡実験法とトリガーの開発Principal Investigator
- Principal Investigator
  
  原田繁春
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
生体系金属活性種の構造化学的研究
- Principal Investigator
  
  甲斐泰
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
放射光を利用した時間分割ラウエ法による酵素反応過程追跡実験法とトリガーの開発Principal Investigator
- Principal Investigator
  
  原田繁春
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Study on the structure-function correlation of CO_2-fixation enzymes toward the industrial application
- Principal Investigator
  
  KAI Yasushi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  工業物理化学
- Research Institution
  Osaka University
Study of Substrate-recognition Mechanism of Zn-metalloproteasePrincipal Investigator
- Principal Investigator
  
  HARADA Shigeharu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  University of Tokyo
  Osaka University
生体系金属活性種の構造化学的研究
- Principal Investigator
  
  甲斐泰
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
生体系金属活性種の構造化学的研究
- Principal Investigator
  
  KAI Yasushi
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
The structure and function of the enzymes concerned with glycolysis
- Principal Investigator
  
  YAMANE Takashi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  結晶学
- Research Institution
  Nagoya University

All 2018 2017 2016 2015 2014 2013 2011 2008 2006 2003 Other

All Journal Article Presentation Book

[Book] Kala Azar in South Asia2017
- Author(s)
  Nozomu Nihashi, Daniel Ken Inaoka, Chiaki Tsuge, Emmanuel Oluwadare Balogun, Yasutaka Osada, Yasuyuki Goto, Yoshitsugu Matsumoto, Takeshi Nara, Tatsushi Mogi, Shigeharu Harada, Kita Kiyoshi
- Total Pages
  309
- Publisher
  Springer International Publishing
- Data Source
  KAKENHI-PROJECT-26253025
[Book] Cytochrome Complexes:Evolution, Structures, Energy Transduction, and Signaling2016
- Author(s)
  Luke Young, Benjamin May, Tomoo Shiba, Shigeharu Harada, Daniel Ken Inaoka, Kiyoshi Kita, Anthony L. Moore
- Total Pages
  739
- Publisher
  Springer Netherlands
- Data Source
  KAKENHI-PROJECT-26253025
[Journal Article] Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors2018
- Author(s)
  Yamashita Tetsuo, Inaoka Daniel Ken, Shiba Tomoo, Oohashi Takumi, Iwata So, Yagi Takao, Kosaka Hiroaki, Miyoshi Hideto, Harada Shigeharu, Kita Kiyoshi, Hirano Katsuya
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 2427-2427
- DOI
  10.1038/s41598-018-20775-6
- NAID
  120006532084
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17F17420, KAKENHI-PROJECT-15K07005
[Journal Article] Design and Synthesis of Potent Substrate-based Inhibitors of the Trypanosoma cruzi Dihydroorotate Dehydrogenase2017
- Author(s)
  D. K. Inaoka, M. Iida, S. Hashimoto, T. Tabuchi,T. Kuranaga, E. O. Balogun, T. Honma, A. Tanaka, S. Harada, T. Nara, K. Kita, M. Inoue
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 25 Issue: 4 Pages: 1465-1470
- DOI
  10.1016/j.bmc.2017.01.009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01130, KAKENHI-PROJECT-26253003, KAKENHI-PROJECT-26253025, KAKENHI-PROJECT-15J12403, KAKENHI-PROJECT-16K15268
[Journal Article] Conjugates of 2,4-Dihydroxybenzoate and Salicylhydroxamate and Lipocations Display Potent Antiparasite Effects by Efficiently Targeting the Trypanosoma brucei and Trypanosoma congolense Mitochondrion.2017
- Author(s)
  Francisco Jose Fueyo Gonzalez, Godwin U. Ebiloma, Carolina Izquierdo Garcia, Victor Bruggeman, Jose Maria Sanchez Villamanan, Anne Donachie, Emmanuel Oluwadare Balogun, Daniel Ken Inaoka, Tomoo Shiba, Shigeharu Harada, Kiyoshi Kita, Harry P. de Koning, Christophe Dardonville
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 60(4) Issue: 4 Pages: 1509-1522
- DOI
  10.1021/acs.jmedchem.6b01740
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253025, KAKENHI-PROJECT-26440027
[Journal Article] The Open Form Inducer Approach for Structure-Based Drug Design2016
- Author(s)
  D. K. Inaoka, M. Iida, T. Tabuchi, T. Honma, N. Lee, S. Hashimoto, S. Matsuoka, T. Kuranaga, K. Sato, T. Shiba, K. Sakamoto, E. O. Balogun, S. Suzuki, T. Nara, J. R. Rocha, C. A. Montanari, A. Tanaka, M. Inoue, K. Kita, S. Harada
- Journal Title
  
  PLoS ONE
  
  Volume: 11 Issue: 11 Pages: e0167078-e0167078
- DOI
  10.1371/journal.pone.0167078
- NAID
  120006987593
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01130, KAKENHI-PROJECT-26253003, KAKENHI-PROJECT-26253025, KAKENHI-PROJECT-15J12403, KAKENHI-PROJECT-26304041, KAKENHI-PROJECT-26460504, KAKENHI-PROJECT-16K15268
[Journal Article] Pharmacophore Modeling for Anti-Chagas Drug Design Using the Fragment Molecular Orbital Method2015
- Author(s)
  Ryunosuke Yoshino, Nobuaki Yasuo, Daniel Ken Inaoka, Yohsuke Hagiwara, Kazuki Ohno, Masaya Orita, Masayuki Inoue, Tomoo Shiba, Shigeharu Harada, Teruki Honma, Emmanuel Oluwadare Balogun, Josmar Rodrigues Da Rocha, Carlos Alberto Montanari, Kiyoshi Kita, Masakazu Sekijima
- Journal Title
  
  PLoS One
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26870119
[Journal Article] 2.Pharmacophore Modeling for Anti-Chagas Drug Design Using the Fragment Molecular Orbital Method2015
- Author(s)
  Yoshino R, Yasuo N, Inaoka DK, Hagiwara Y, Ohno K, Orita M, Inoue M, Shiba T, Harada S, Honma T, Balogun EO, da Rocha JR, Montanari CA, Kita K, Sekijima M
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 5 Pages: 1-15
- DOI
  10.1371/journal.pone.0125829
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440027, KAKENHI-PROJECT-24240044, KAKENHI-PROJECT-26253003, KAKENHI-PROJECT-26253025, KAKENHI-PROJECT-15H02776, KAKENHI-PROJECT-26870119
[Journal Article] 1.Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria2015
- Author(s)
  Inaoka DK, Shiba T, Sato D, Balogun EO, Sasaki T, Nagahama M, Oda M, Matsuoka S, Ohmori J, Honma T, Inoue M, Kita K, Harada S
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 16 Issue: 7 Pages: 15287-15308
- DOI
  10.3390/ijms160715287
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440027, KAKENHI-PROJECT-26253003, KAKENHI-PROJECT-26870119
[Journal Article] Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria2015
- Author(s)
  Daniel Ken Inaoka, Tomoo Shiba, Dan Sato, Emmanuel Oluwadare Balogun, Tsuyoshi Sasaki, Madoka Nagahama, Masatsugu Oda, Shigeru Matsuoka, Junko Ohmori, Teruki Honma, Masayuki Inoue, Shigeharu Harada, and Kiyoshi Kita
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26870119
[Journal Article] Molecular basis for the reverse reaction of African human trypanosomes glycerol kinase2014
- Author(s)
  Emmanuel Oluwadare Balogun, Daniel Ken Inaoka, Tomoo Shiba, Yasutoshi Kido, Chiaki Tsuge, Takeshi Nara, Takashi Aoki, Teruki Honma, Akiko Tanaka, Masayuki Inoue, Shigeru Matsuoka, Paul A.M. Michels, Kiyoshi Kita, Shigeharu Harada
- Journal Title
  
  Molecular Microbiology
  
  Volume: 94 Issue: 6 Pages: 1315-1329
- DOI
  10.1111/mmi.12831
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370050, KAKENHI-PROJECT-24390102, KAKENHI-PROJECT-25670205, KAKENHI-PROJECT-26253003, KAKENHI-PROJECT-26440027
[Journal Article] Anemia amelioration by lactose infusion during trypanosomiasis could be associated with erythrocytes membrane de-galactosylation2014
- Author(s)
  Balogun, EO., Balogun, JAB., Yusuf, S., Inuwa, HM., Ndams, IS., Sheridan, P., Inaoka, DK., Shiba, T., Harada, S., Kita, K., Esievo, KAN., Nok AJ.
- Journal Title
  
  Veterinary Parasitology
  
  Volume: 199 Issue: 3-4 Pages: 259-263
- DOI
  10.1016/j.vetpar.2013.10.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12F02102, KAKENHI-PROJECT-23370050
[Journal Article] Probing the ubiquinol-binding site of recombinant Sauromatum guttatum alternative oxidase expressed in E. coli membranes through site-directed mutagenesis2014
- Author(s)
  Luke Young, Benjamin May, Alice Pendlebury-Watt, Julia Shearman, Catherine Elliott, Mary S. Albury, Tomoo Shiba, Daniel Ken Inaoka, Shigeharu Harada, Kiyoshi Kita, Anthony L. Moore
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Bioenergetics
  
  Volume: 1837 Issue: 7 Pages: 1219-1225
- DOI
  10.1016/j.bbabio.2014.01.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370050, KAKENHI-PROJECT-26440027
[Journal Article] Identification and Characterization of Sialidase-Like Activity in the Developmental Stages of Amblyomma Variegatum2013
- Author(s)
  Audu J. Natala, Emmanuel 0. Balogun, Joshua A. B. Balogun, Hajiya M. Inuwa, Andrew J. Nok, Tomoo Shiba, Shigeharu Harada,Kiyoshi Kita, Rowland l. S. Agbede, King A. N. Esievo
- Journal Title
  
  Journal of Medical Entomology
  
  Volume: 50 (1) Issue: 1 Pages: 85-93
- DOI
  10.1603/me12152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12F02102, KAKENHI-PROJECT-23370050, KAKENHI-PROJECT-23570131
[Journal Article] Structure of the trypanosome cyanide-insensitive alternative oxidase2013
- Author(s)
  Tomoo Shiba, Yasutoshi Kido, Kimitoshi Sakamoto, Daniel Ken Inaoka, Chiaki Tsuge, Ryoko Tatsumi,Gen Takahashi, Emmanuel Oluwadare Balogun, Takeshi Nara, Takashi Aoki, Teruki Honma, Akiko Tanaka, Masayuki Inoue, Shigeru Matsuoka, Hiroyuki Saimoto, Anthony L. Moore, Shigeharu Harada, Kiyoshi Kita
- Journal Title
  
  Proc. Nat1. Acad. Sci. USA
  
  Volume: 110 (12) Issue: 12 Pages: 4580-4585
- DOI
  10.1073/pnas.1218386110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12F02102, KAKENHI-PROJECT-22310158, KAKENHI-PROJECT-23370050, KAKENHI-PROJECT-23402046, KAKENHI-PROJECT-24390102, KAKENHI-PROJECT-25670205
[Journal Article] The alternative oxidases: simple oxidoreductase proteins with complex functions2013
- Author(s)
  Luke Young, Tomoo Shiba, Shigeharu Harada, Kiyoshi Kita, Mary S. Albury, Anthony L. Moore
- Journal Title
  
  Biochem. Soc. Trans.
  
  Volume: 41 Issue: 5 Pages: 1305-1311
- DOI
  10.1042/bst20130073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370050, KAKENHI-PROJECT-23570131
[Journal Article] Diversity of parasite complex II2013
- Author(s)
  Shigeharu Harada, Daniel Ken Inaoka, Junko Ohmori, Kiyoshi Kita
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Bioenergetics
  
  Volume: 1827 Issue: 5 Pages: 658-667
- DOI
  10.1016/j.bbabio.2013.01.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370050
[Journal Article] Unraveling the Heater: New Insights into the Structure of the Alternative Oxidase2013
- Author(s)
  Anthony L. Moore, Tomoo Shiba, Luke Young, Shigeharu Harada, Kiyoshi Kita, Kikukatsu Ito
- Journal Title
  
  Annual Review of Plant Biology
  
  Volume: 64 Issue: 1 Pages: 637-663
- DOI
  10.1146/annurev-arplant-042811-105432
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370050, KAKENHI-PROJECT-23570131, KAKENHI-PROJECT-24380182
[Journal Article] A Drosophila model for the screening of bioavailable NADPH oxidase inhibitors and antioxidants2011
- Author(s)
  Nguyen Thi Tu Anh, Maiko Nishitani, Shigeharu Harada, Masamitsu Yamaguchi, Kaeko
- Journal Title
  
  Mol Cell Biochem.
  
  Volume: 352 Pages: 91-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370050
[Journal Article] A Conserved Lysine Residue in the Crenarchaea-Specific Loop is Important for the Crenarchaeal Splicing Endonuclease Activity2011
- Author(s)
  Maho Okuda, Tomoo Shiba, Daniel-Ken Inaoka, Kiyoshi Kita, Genji Kurisu, Shigeru Mineki, Shigeharu Harada, Yoh-ichi Watanabe, Shigeo Yoshinari
- Journal Title
  
  J.Mol.Biol.
  
  Volume: 405 Pages: 92-104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370050
[Journal Article] Essential Role of Duox in Stabilization of Drosophila Wing2011
- Author(s)
  Nguyen Thi Tu Anh, Maiko Nishitani, Shigeharu Harada, Masamitsu Yamaguchi, Kaeko Kamei
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 286 Pages: 33244-33251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370050
[Journal Article] Inhibition assay of b-hematin formation initiated by lecithin for screening new antimalarial drugs2006
- Author(s)
  Dai Thi Xuan Trang, Nguyen Tien Huy, Dinh Thanh Uyen, Motohiro Sasai, Takeshi Shiono, Shigeharu Harada, Kaeko Kamei
- Journal Title
  
  Analytical Biochemistry 349
  
  Pages: 292-296
- Data Source
  KAKENHI-PROJECT-18370042
[Journal Article] Simple Colorimetric Inhibition Assay of Heme Crystallization for High-Throughput Screening of Antimalarial Compounds2006
- Author(s)
  Nguyen Tien Huy, Dinh Thanh Uyen, Atsushi Maeda, Dai Thi Xuan Trang, Tatso Oida, Shigeharu Harada, Kaeko Kamei
- Journal Title
  
  Antimicrobial Agents and Chemotherapy, Jpn. 51
  
  Pages: 350-353
- Data Source
  KAKENHI-PROJECT-18370042
[Journal Article] A simple and rapid colorimetric method to measure hemozoin crystal growth in vitro2006
- Author(s)
  Nguyen Tien Huy, Dinh Thanh Uyen, Motohiro Sasai, Dai Thi Xuan Trang, Takeshi Shiono, Shigeharu Harada, kaeko Kamei
- Journal Title
  
  Analytical Biochemistry 354
  
  Pages: 305-307
- Data Source
  KAKENHI-PROJECT-18370042
[Journal Article] Serine proteinase inhibitor from wax gourd (Benincasa hisida Thunb Cogn.) seeds2006
- Author(s)
  Panida Atiwetin, Shigeharu Harada, Kaeko Kamei
- Journal Title
  
  Biosci. Biotechnol. Biochem. 70
  
  Pages: 743-745
- Data Source
  KAKENHI-PROJECT-18370042
[Journal Article] Direct evidence for two distinct forms of the flavoprotein subunit of human mitochondrial complex II (succinate-ubiquinone reductase).2003
- Author(s)
  Tomitsuka, E., Hirawake, H., Goto, Y., Taniwaki, M., Harada, S., Kita, K.
- Journal Title
  
  J. Biochem. 134
  
  Pages: 191-195
- NAID
  10012056682
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13854011
[Presentation] 競合および混合阻害剤との共結晶構造解析により明らかとなった出芽酵母由来Type II NADH脱水素酵素のユビキノン結合部位2018
- Author(s)
  山下哲生，稲岡健ダニエル，志波智生，大橋匠，岩田想，矢木隆雄，三芳秀，原田繁春，北潔，平野勝也
- Organizer
  日本農芸化学会中四国支部第51回講演会
- Data Source
  KAKENHI-PROJECT-15K07005
[Presentation] 結晶構造から見たフルトラニルおよびその誘導体化合物の回虫成虫複合体Ⅱに対する特異性2015
- Author(s)
  米愛加, 長濱まどか, 梅本亮, 山本京史, 佐藤暖, 志波智生, 稲岡ダニエル健, 福田智美, 織田雅次, 北潔, 原田繁春
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26870119
[Presentation] 低酸素環境下で生息する回虫成虫複合体Ⅱの構造・機能相関と特異的阻害剤の開発2015
- Author(s)
  原田繁春、稲岡　ダニエル健、北潔
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26870119
[Presentation] 寄生線虫類のミトコンドリア酸呼吸と宿主内微小環境適応。2015
- Author(s)
  稲岡ダニエル健, Ferdoush Zannatul, 大森淳子, 福田智美, 福本晋也, 福本真一郎, 志波智生, 原田繁春 , 北潔
- Organizer
  第２３回分子寄生虫学ワークショップ／第１３回分子寄生虫・マラリア研究フォーラム合同大会
- Place of Presentation
  帯広畜産大学
- Year and Date
  2015-08-30
- Data Source
  KAKENHI-PROJECT-26870119
[Presentation] 原虫ミトコンドリオンの酢酸代謝2015
- Author(s)
  稲岡ダニエル健、Emmanuel O. Balogun、鈴木重雄、志波智生、原田繁春、Frederic Bringaud、北潔
- Organizer
  YoungMito 2015
- Place of Presentation
  千葉・ホテルシーサイド一宮オーツカ
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PROJECT-26870119
[Presentation] 線虫類のフマル酸呼吸と宿主内微小環境適応2015
- Author(s)
  Daniel Ken Inaoka , Zannatul Ferdoush, Ohmori Junko, Fukuda Tomomi, Shinya Fukumoto, Shinichiro Fukumoto, Shiba Tomoo, Harada Shigeharu and Kiyoshi Kita
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26870119
[Presentation] 出芽酵母由来Type II NADH dehydrogenase (NDH-2)のユビキノン競合阻害剤との高分解能複合体構造解析2015
- Author(s)
  大橋拓未、稲岡ダニエル健、山下哲生、志波智生、岩田想、原田繁春、北潔
- Organizer
  日本生体エネルギー研究会　第41回討論会
- Place of Presentation
  東京大学医学部1号館講堂
- Year and Date
  2015-12-23
- Data Source
  KAKENHI-PROJECT-15K07005
[Presentation] 寄生虫の低酸素エネルギー代謝経路を標的にした構造生命科学による創薬2014
- Author(s)
  原田繁春、北潔
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-16
- Data Source
  KAKENHI-PROJECT-26253025
[Presentation] 赤痢アメーバ由来メチオニンγ-リアーゼの構造生物学的研究2014
- Author(s)
  坂井菜摘、近藤輝、岡知宏、唐木剛、村野祥子、野崎智義、佐藤暖、原田繁春、志波智生
- Organizer
  第８７回日本生化学会大会
- Place of Presentation
  京都市
- Year and Date
  2014-10-16
- Data Source
  KAKENHI-PROJECT-23370050
[Presentation] 赤痢アメーバ由来メチオニンγリアーゼ２の結晶構造解析2014
- Author(s)
  近藤輝、酒井菜摘、岡知宏、村、唐木剛、野崎智義、佐藤暖、志波智生、原田繁春
- Organizer
  第１４回日本蛋白質科学会年会
- Place of Presentation
  横浜市
- Year and Date
  2014-06-26
- Data Source
  KAKENHI-PROJECT-23370050
[Presentation] Pseudomonas putida由来メチオニンγリアーゼの結晶構造解析2014
- Author(s)
  湯之戸俊介、古谷和大、福本充樹、工藤大蔵、志波智生、佐藤暖、田村隆、原田繁春、稲垣賢二
- Organizer
  第１４回日本蛋白質科学会年会
- Place of Presentation
  横浜市
- Year and Date
  2014-06-25
- Data Source
  KAKENHI-PROJECT-23370050
[Presentation] Pseudomonas putida由来メチオニンγ-リアーゼの結晶構造解析2014
- Author(s)
  湯之戸俊介、安田江里、古谷和大、福本充樹、工藤大蔵、志波智生、佐藤暖、田村隆、原田繁春、稲垣賢二
- Organizer
  第８７回日本生化学会大会
- Place of Presentation
  京都市
- Year and Date
  2014-10-16
- Data Source
  KAKENHI-PROJECT-23370050
[Presentation] 高度好熱菌Sulfolobus tokodai由来シスタチオニン合成酵素の結晶構造2014
- Author(s)
  川村あやか、花田尚子、山田哲也、田村隆、佐藤暖、志波智生、稲垣賢二、原田繁春
- Organizer
  第８７回日本生化学会大会
- Place of Presentation
  京都市
- Year and Date
  2014-10-16
- Data Source
  KAKENHI-PROJECT-23370050
[Presentation] 好熱好酸性アーキアSulfolobus tokodaii由来シスタチオニン合成酵素のX線結晶構造解析2013
- Author(s)
  清水あやか、花田尚子、山田哲也、田村隆、志波智生、稲垣賢二、原田繁春
- Organizer
  第１３回日本蛋白質科学会年会
- Place of Presentation
  鳥取
- Data Source
  KAKENHI-PROJECT-23370050
[Presentation] 赤痢アメーバ由来メチオニンγ -リアーゼの精製と結晶構造解析2013
- Author(s)
  酒井菜摘、岡知宏、村野祥子、唐木剛、野崎智義、佐藤暖、志波智生、原田繁春
- Organizer
  第１３回日本蛋白質科学会年会
- Place of Presentation
  鳥取
- Data Source
  KAKENHI-PROJECT-23370050
[Presentation] Pseudomonas putida由来メチオニン γ-リアーゼの結晶構造解析2013
- Author(s)
  古谷和大、湯之戸俊介、福本充樹、工藤大蔵、志波智生、佐藤暖、田村隆、原田繁春、稲垣賢二
- Organizer
  第８６回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23370050
[Presentation] 赤痢アメーバ由来メチオニンγ-リアーゼの結晶学的構造解析2013
- Author(s)
  酒井菜摘、岡知宏、唐木剛、村野祥子、近藤輝、佐藤暖、野崎智義、原田繁春、志波智生
- Organizer
  第８６回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23370050
[Presentation] 好熱好酸性アーキアSulfolobus tokodaii由来シスタチオニン γ‐シンターゼの構造解析2013
- Author(s)
  清水あやか花田尚子、山田哲也、田村隆、佐藤暖、志波智生、稲垣賢二、原田繁春
- Organizer
  第８６回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23370050
[Presentation] クルーズトリパノソーマ由来アスパラギン酸トランスカルバモイラーゼと阻害剤複合体のX線結晶解析2011
- Author(s)
  藤田康介、的場一晃、奈良武司、青木孝、幸瞳、本間光貴、田仲昭子、松高祥子、松岡茂、井上将行、志波智生、稲岡ダニエル健、北潔、原田繁春
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都(国立京都国際会館)
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-23370050
[Presentation] Structural analysis of glycerol kinase from human African trypanosomes for anti-trypanosomal drug design2011
- Author(s)
  Balogun Emmanuel O.、稲岡ダニエル健、志波智生、城戸康年、奈良武司、青木孝、本間光貴、田仲昭子、井上将行、松岡茂、Michels Paul AM.、原田繁春、北潔
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都(国立京都国際会館)
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-23370050
[Presentation] 寄生虫ミトコンドリア呼吸鎖膜タンパク質の立体構造と論理的阻害剤設計2011
- Author(s)
  原田繁春、稲岡ダニエル、松岡茂、志波智生、坂元君年、奈良武司、青木孝、井上将行、本間光貴、田仲昭子、北潔
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都(国立京都国際会館)
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-23370050
[Presentation] Structure based design and development of inhibitors with high specificity and inhibitory activity against mitochondrial rhodoquinol-fumarate reductase from the parasitic nematode Ascaris suum2011
- Author(s)
  S.Harada
- Organizer
  IUMS : International Congress of Bacteriology and Applied Microbiology (BAM), and the International Congress of Mycology
- Place of Presentation
  札幌(札幌コンベンションセンター)(招待講演)
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PROJECT-23370050
[Presentation] Pseudomonas putida由来L-メチオニンγ-リアーゼの活性中心残基の機能解析2011
- Author(s)
  山田哲也、福本充樹、工藤大蔵、原田繁春、田村隆、稲垣賢二
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都(国立京都国際会館)
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-23370050
[Presentation] 赤痢アメーバメチオニンγ-リアーゼ1の結晶中で捉えたα,γ-脱離反応機構2011
- Author(s)
  岡知宏、佐藤暖、村野祥子、唐木剛、中沢隆、野崎智義、原田繁春
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都(国立京都国際会館)
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-23370050
[Presentation] クルーズトリパノソーマ由来アスパラギン酸トランスカルバモイラーゼと阻害剤との複合体構造2011
- Author(s)
  的場一晃、藤田康介、奈良武司、青木孝、幸瞳、本間光貴、田仲昭子、松高祥子、松岡茂、井上将行、志波智生、稲岡ダニエル健、北潔、原田繁春
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  大阪(ホテル阪急エキスポパーク)
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-23370050
[Presentation] トリパノソーマ原虫のミトコンドリアの内膜に局在する「シアン耐性酸化酵素Trypanosome Alternative Oxidase (TAO)」の結晶構造2011
- Author(s)
  志波智生、城戸康年、稲岡ダニエル健、坂元君年、奈良武司、青木孝、本間光貴、田仲昭子、井上将行、松岡茂、斎本博之、ムーア・アンソニー、原田繁春、北潔
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都(国立京都国際会館)
- Year and Date
  2011-09-21
- Data Source
  KAKENHI-PROJECT-23370050
[Presentation] トキソプラズマ原虫の活性型ヌクレオシド三リン酸加水分解酵素の構造2011
- Author(s)
  濱崎遥香、的場一晃、志波智生、竹内勤、浅井隆志、原田繁春
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都(国立京都国際会館)
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-23370050
[Presentation] トリパノソーマクルージのジヒドロオロト酸脱水素酵素に対する選択的阻害剤の設計2011
- Author(s)
  稲岡ダニエル健、飯田舞子、田淵俊行、松岡茂、志波智生、坂元君年、鈴木重雄、奈良武司、青木孝、井上将行、本間光貴、田仲昭子、原田繁春、北潔
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都(国立京都国際会館)
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-23370050
[Presentation] トキソプラズマ原虫由来NTPaseの活性型変異体の構造2011
- Author(s)
  濱崎遥香、的場一晃、志波智生、竹内勤、浅井隆志、原田繁春
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  大阪(ホテル阪急エキスポパーク)
- Year and Date
  2011-06-08
- Data Source
  KAKENHI-PROJECT-23370050
[Presentation] 赤痢アメーバメチオニンγ-リアーゼ1の結晶中で捉えたα,γ-脱離反応進行に伴うスナップショット構造2011
- Author(s)
  岡知宏、佐藤暖、村野祥子、唐木剛、中沢隆、野崎智義、原田繁春
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  大阪(ホテル阪急エキスポパーク)
- Year and Date
  2011-06-08
- Data Source
  KAKENHI-PROJECT-23370050
[Presentation] Crystallization and X-ray structure analysis of Complex II from adult Ascaris suum mitochondria2008
- Author(s)
  原田繁春
- Organizer
  XXI Congress of the International Union of Crystallographi
- Place of Presentation
  大阪
- Year and Date
  2008-08-28
- Data Source
  KAKENHI-PROJECT-19036010
[Presentation] 核酸およびレドックス調節パスウェイを標的とする抗トリパノソーマ薬の開発-回虫およびブタミトコンドリア呼吸鎖複合体IIをモデル蛋白質とした特異的阻害剤の開発-2008
- Author(s)
  原田繁春
- Organizer
  第7回分子寄生虫・マラリア研究フォーラム
- Place of Presentation
  松山
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-19036010
[Presentation] ブタおよび回虫成虫ミトコンドリア複合体IIに対する阻害剤の結合様式2008
- Author(s)
  原田繁春
- Organizer
  第8回日本蛋白質科学会年会
- Place of Presentation
  東京
- Year and Date
  2008-06-11
- Data Source
  KAKENHI-PROJECT-19036010
[Presentation] Dissociation constant (Kd) of Trypanosoma brucei alternative oxidase inhibitors and their trypanocidal activity
- Author(s)
  Daniel Ken Inaoka, Tomoo Shiba, Tsuge Chiaki, Chou Rihe, Gen Takahashi, Satoshi Ueda, Yasutoshi Kido, Emmanuel Oluwadare Balogun, Kimitoshi Sakamoto, Takeshi Nara, Teruki Honma, Akiko Tanaka, Masayuki Inoue, Hiroyuki Saimoto, Anthony Moore, Shigeharu Harada, Kiyoshi Kita
- Organizer
  第84回日本寄生虫学会大会
- Place of Presentation
  杏林大学三鷹キャンパス
- Year and Date
  2015-03-21 – 2015-03-22
- Data Source
  KAKENHI-PROJECT-26870119
[Presentation] Chemical validation of 12-subunits respiratory Complex II from Trypanosomatid as drug target
- Author(s)
  Daniel Ken Inaoka, Nozomu Nihashi, Chiaki Tsuge, Takeshi Nara, Shigeharu Harada, Kiyoshi Kita
- Organizer
  13th International Congress of Parasitology
- Place of Presentation
  Camino Real Hotel, Mexico City
- Year and Date
  2014-08-10 – 2014-08-15
- Data Source
  KAKENHI-PROJECT-26870119
[Presentation] トリパノソーマ科原虫ミトコンドリアのATP合成における酢酸代謝の役割。
- Author(s)
  稲岡ダニエル健、鈴木重雄、Emmanuel O. Balogun、原田繁春、Frédéric Bringaud、北潔
- Organizer
  日本生体エネルギー研究会、第４０回討論会
- Place of Presentation
  愛媛大学　南加記念ホール
- Year and Date
  2014-12-11 – 2014-12-13
- Data Source
  KAKENHI-PROJECT-26870119
[Presentation] Crystal structures of Pseudomonas putida L-methionine γ-lyase and its C116H mutant enzyme complexed with substrate: Insights into the substrate recognition mechanism
- Author(s)
  Eri Yasuda, Mitsuki Fukumoto, Kazuo Furutani, Syunsuke Yunoto, Takashi Tamura, Tomoo Shiba, Dan Sato, Shigeharu Harada and Kenji Inagaki
- Organizer
  The Fourth International Conference on Cofactors
- Place of Presentation
  イタリアパルマ市
- Year and Date
  2014-08-25 – 2014-08-28
- Data Source
  KAKENHI-PROJECT-23370050
[Presentation] Pyrimidine de novo biosynthesis under tumor microenvironment
- Author(s)
  Daniel Ken Inaoka, Yukiko Hirota, Takahiro Sasagawa, Eriko Tomitsuka, Chika Sakai, Hiroyuki Saimoto, Shigeharu Harada, Kiyoshi Kita
- Organizer
  第37回日本分子生物学会年会（ワークショップ）
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Invited
- Data Source
  KAKENHI-PROJECT-26870119
[Presentation] ヒトミトコンドリアDHODHを標的とした分子創薬
- Author(s)
  Daniel Ken Inaoka、Hiroyuki Saimoto 、Shigeharu Harada 、Kiyoshi Kita
- Organizer
  第二回　YoungMito
- Place of Presentation
  大阪府箕面・みのお山荘「風の杜」
- Year and Date
  2014-05-22 – 2014-05-23
- Data Source
  KAKENHI-PROJECT-26870119
[Presentation] Characterization of Eimeria tenella sporozoite mitochondria
- Author(s)
  稲岡ダニエル健、松林　誠、小松谷啓介、八田岳士、三好猛晴、磯部　尚、川原史也、山岸潤也、彦坂健児、佐藤暖、志波智生、原田繁春、辻　尚利、北　潔
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26870119
[Presentation] Eimeria tenella スポロゾイトのミトコンドリア精製法の確立と呼吸鎖酵素活性
- Author(s)
  松林　誠、稲岡ダニエル健、小松谷啓介、八田岳士、三好猛晴、磯部　尚、川原史也、山岸潤也、彦坂健児、佐藤暖、志波智生、原田繁春、北　潔、辻　尚利
- Organizer
  第157回日本獣医学会学術集会
- Place of Presentation
  北海道大学高等教育推進機構
- Year and Date
  2014-09-09 – 2014-09-12
- Data Source
  KAKENHI-PROJECT-26870119
[Presentation] Eimeria tenellaスポロゾイト呼吸鎖の生化学的解析
- Author(s)
  稲岡ダニエル健、松林　誠、小松谷啓介、八田岳士、三好猛晴、磯部　尚、川原史也、山岸潤也、彦坂健児、佐藤暖、志波智生、原田繁春、辻　尚利、北　潔
- Organizer
  第22回分子寄生虫学ワークショップ／第12回分子寄生虫・マラリア研究フォーラム合同大会
- Place of Presentation
  帯広畜産大学・原虫病研究センター、PKホール
- Year and Date
  2014-08-31 – 2014-09-03
- Data Source
  KAKENHI-PROJECT-26870119
[Presentation] L-メチオニン γ-リアーゼ基質複合体のX線結晶構造解析と基質認識に関わる残基の機能解析
- Author(s)
  安田江里，古谷和大，佐藤暖，福本充樹，工藤大蔵，志波智生，原田繁春，田村隆，稲垣賢二
- Organizer
  日本ビタミン学会第６６回大会
- Place of Presentation
  姫路市
- Year and Date
  2014-06-13 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-23370050

1. KITA Kiyoshi (90134444)

# of Collaborated Projects: 7 results

# of Collaborated Products: 22 results
2. KAI Yasushi (40029236)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. INAOKA KEN DANIEL (10623803)

# of Collaborated Projects: 3 results

# of Collaborated Products: 20 results
4. MIYOSHI Hideto (20190829)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. AMINO Hisako (10323601)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. WATANABE Yohichi (90323568)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. KAMEI Kaeko (00214544)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. SAIMOTO Hiroyuki (20186977)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
9. YAMANE Takashi (80030055)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MATSUMOTO Osamu (10231599)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. FUKUYAMA Keiichi (80032283)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MATSUURA Yoshiki (90029968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. IIJIMA Shinji (00168056)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. INOUE Tsuyoshi (20263204)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KANEHISA Nobuko (20177538)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KURIHARA Yoshie (90017715)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. OHTANI Hiroyuki (30213763)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. MIZUTANI Ryuta (70272482)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. NOGUCHI Syuji (60237823)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. HONMA Teruki (10466039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
21. Yamashita Tetsuo (80444727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
22. SHIBA Tomoo (80401206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
23. 鳥居本美 (20164072)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. BALOGUN E.O.

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
25. 井上将行

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
26. 林加恵子

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

HARADA shigeharu 原田 繁春

HARADA Shigeharu 原田 繁春

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Structural characterization of reaction pathway in a PLP-enzyme, methionine gamma-lyase: crystallographic snapshots of key intermediatesPrincipal Investigator

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ウシ心筋ミトコンドリア電子伝達系に存在する膜蛋白質会合体の構造研究Principal Investigator

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Studies on the structure and function relationship offumarate redudase from adut Ascais suumPrincipal Investigator

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膜結合性コハク酸ユビキノン酸化還元酵素複合体のX線結晶解析Principal Investigator

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膜結合性コハク酸ユビキノン酸化還元酵素複合体のX線構造解析Principal Investigator

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大腸菌の膜結合性コハク酸ユビキノン酸化還元酵素複合体のX線構造解析Principal Investigator

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Time-resolved X-ray Crystal Structure Analysis of ProteinPrincipal Investigator

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HARADA shigeharu 原田繁春

HARADA Shigeharu 原田繁春