OKUDA Seiya 奥田誠也

Researcher Number	80158823
Affiliation (based on the past Project Information) *help	2010 – 2012: 久留米大学, 医学部, 教授 2007 – 2008: Kurume University, 医学部, 教授 2001 – 2004: KURUME UNIVERSITY SCHOOL OF MEDICINE, PROFESSOR, 医学部, 教授 1996 – 1999: 久留米大学, 医学部, 教授 1995: KYUSHU UNIVERSITY,FACULTY OF MEDICINE,THE SECOND DEPARTMENT OF INTERNAL MEDICINE,ASSOCIATE PROFESSOR, 医学部, 助教授 1994: Kyushuu University.Internal Medicine.Assistant Professor, 医学部, 講師 1993: 九州大学, 医学部, 教授
Review Section/Research Field	Principal Investigator Kidney internal medicine / Kidney internal medicine Except Principal Investigator Kidney internal medicine / General anatomy (including Histology/Embryology)
Keywords	Principal Investigator TGF-β / matrix / Glomerulosclerosis / Growth factor / マトリックス / 増殖因子 / Renal fibrosis / Soluble receptor / 遺伝子導入 / アデノウイルス … More / TGF-βレセプター / LTBP / 糸球体硬化 / 糸球体腎炎 / TGF-β活性化 / TGF-β局在 / ADMA / DDAH / 内皮機能障害 / CKD / 慢性腎臓病 / TGF-β acctivation / endothelial cell / tubulointerstitial fibrosis / CD34 positive cell / glomerulosclerosis / vasculogenesis / angiogenesis / renal regeneration / 分化誘導 / 内皮前駆細胞 / 線維化 / 硬化 / 再構築 / 腎組織 / 臍帯血 / 尿細管間質障害 / CD34陽性細胞 / 血管新生 / 内皮細胞 / 腎組織再構築 / TGF-β activation / TGF-beta acctivation / TGF-beta localization / TGF-beta / 糸球体疾患 / 基質 / 腎線維化 / 可溶性レセプター / TGF-b acctivation / TGF-b localization / Interstitial fibrosis / TGF-b binding protein / TGF-b / 尿細管細胞 / PCR / 間質線維化 / TGF-β結合蛋白 / 脂肪細胞 / 微量アルブミン尿 / 心腎連関 / 内皮障害 / インスリン抵抗性 / メタボリック症候群 / NO / 心血管病 / ADMA DDAH / 蛋白尿 / 一酸化窒素 … More Except Principal Investigator Smad / TGF-β / Transporter / Hormone / Basement Membrane / Nephron / Glomerulus / Cloning / Nephrology / Molecular biology / Smad binding element / CAPD / Adenovirus-vector / peritoneal fibrosis / Growth factor / 遺伝子導入 / 線維化 / 細胞外マトリックス / Smad結合領域 / アデノウイルスベクター / 腹膜硬化症 / 腹膜透析 / 増殖因子 / Basement membrane / cloning / Transportor / 3次元構造解析 / 超微構造観察 / BFI / FIB/SEM tomography / compartmentalization / 線維芽細胞 / 間葉細胞 / ミトコンドリア / 三次元再構築 / 超微細構造 / FIB/SEM / 電子顕微鏡 Less

ptimization of FIB/SEM techniques ? the novel ultrastructureeanalysis by combination of serial thin ablation and block surface material contrastobservation - for biomedical mesoscale three dimentional structural analysis.
- Principal Investigator
  
  NAKAMURA Kei-ichiro
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Kurume University
Missing link between metabolic syndrome and chronic kidney disease.?Role of asymmetric dimethylarginine-Principal Investigator
- Principal Investigator
  
  OKUDA Seiya
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kurume University
ADMA metabolism and microvascular damage in chronic renal diseasesPrincipal Investigator
- Principal Investigator
  
  OKUDA Seiya
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kurume University
ROLE OF AND REGULATION OF GROWTH FACTOR TGF-β IN GLOMERULAR LESIONSPrincipal Investigator
- Principal Investigator
  
  OKUDA Seiya
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  KURUME UNIVERSITY
REGULATION OF TGF_ACTIVITY FOR ATTENUATION OF GLOMERULAR LESIONSPrincipal Investigator
- Principal Investigator
  
  OKUDA Seiya
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  KURUME UNIVERSITY
REGULATION OF TGF-β AND ITS SIGNAL MOLECULE, SMAD FOR ATTENUATION OF PERITONEAL FIBROSIS.
- Principal Investigator
  
  KOHNO Keisuke
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kurume University
REGULATION OF TGF-β ACTIVITY FOR ATTENUATION OF GLOMERULAR LESIONSPrincipal Investigator
- Principal Investigator
  
  OKUDA Seiya
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  KURUME UNIVERSITY
REGULATION OF TGF-beta ACTIVITY FOR ATTENUATION OF GLOMERULAR LESIONSPrincipal Investigator
- Principal Investigator
  
  OKUDA Seiya
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  KURUME UNIVERSITY
THE PERSISTENT ACTIVATION MECHANISM OF TGF-b IN PROGRESSIVE GLOMERULAR DISEASESPrincipal Investigator
- Principal Investigator
  
  OKUDA Seiya
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  KYUSHU UNIVERSITY
Molecular Biology of the Kidney-Molecular Analysis of Structure and Function Relationship
- Principal Investigator
  
  MARUMO Fumiaki
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokyo Medical and Dental University

All 2013 2012 2011 2010 2009 2008 2007 2004 2003 2002 2001 2000 Other

All Journal Article Presentation Book

[Book] Cell Growth Processes : New research2008
- Author(s)
  Ueda S, Okuda S
- Publisher
  Nova publisher
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Role of asymmetric dimethylargine in cardiorenal syndrome2013
- Author(s)
  Ueda S, Okuda S, et al.
- Journal Title
  
  Current Pharmaceutical Design
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590903
[Journal Article] Involvement of advanced glycation end product–induced asymmetric dimethylarginine generation in endothelial dysfunction2013
- Author(s)
  Ando R, Okuda S, et al.
- Journal Title
  
  Diabetes & Vascular Disease Research
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590903
[Journal Article] Inhibition of eNOS phosphorylation mediates endothelial dysfunction in renal failure: new effect of asymmetric dimethylarginine.2012
- Author(s)
  Kajimoto H, Kai H, Aoki H, Yasuoka S, Anegawa T, Aoki Y, Ueda S, Okuda S, Imaizumi T
- Journal Title
  
  Kidney Int.
  
  Volume: 81(8) Pages: 762-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590903
[Journal Article] Pravastatininhibits advanced glycation end products(AGEs)‐induced proximal tubular cellapoptosis and injury by reducing receptorfor AGEs (RAGE) level.2012
- Author(s)
  Ishibashi Y, Yamagishi S, Matsui T,Ohta K, Tanoue Ryuichiro, Takeuchi M, UedaS, Nakamura K, Okuda S.
- Journal Title
  
  Metabolism
  
  Volume: 61 Pages: 1067-1072
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659104
[Journal Article] Proteinuria elevates asymmetric dimethylarginine levels via protein arginine methyltransferase-1 overexpressionin a rat model of nephrotic syndrome.2012
- Author(s)
  Kaida Y, Ueda S, Yamagishi S, Nakayama Y, Ando R, Iwatani R, Fukami K, Okuda S.
- Journal Title
  
  Life Sci.
  
  Volume: 91(9-10) Pages: 301-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590903
[Journal Article] Proteinuria elevates asymmetric dimethylarginine levels via protein arginine methyltransferase-1 overexpression in a rat model of nephrotic syndrome.2012
- Author(s)
  Kaida Y, Okuda S, et al.
- Journal Title
  
  Life Sci.
  
  Volume: 91 Issue: 9-10 Pages: 301-305
- DOI
  10.1016/j.lfs.2012.06.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590903, KAKENHI-PROJECT-22590904, KAKENHI-PROJECT-23591210, KAKENHI-PROJECT-24790866
[Journal Article] A new vasculitis activity score for predicting death in MPO-ANCA associated vasculitis patients2012
- Author(s)
  Seiya Okuda
- Journal Title
  
  Am J Nephrrol
  
  Volume: 35 Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590903
[Journal Article] Pravastatin inhibits advanced glycation end products (AGEs)‐induced proximal tubular cell apoptosis and injury by reducing receptor for AGEs (RAGE) level2012
- Author(s)
  Ishibashi Y, Yamagishi S, Matsui T, Ohta K, Tanoue Ryuichiro, Takeuchi M, Ueda S, Nakamura K, Okuda S.
- Journal Title
  
  Metabolism
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659104
[Journal Article] Inhibition of eNOS Phosphorylation Mediates Endothelial Dysfunction in Renal Failure : New Effect of Asymmetric Dimethylarginine2012
- Author(s)
  Kajimoto H, Kai H, Imaizumi T(他6人9番目)
- Journal Title
  
  Kidney International
  
  Volume: 81 Issue: 8 Pages: 762-768
- DOI
  10.1038/ki.2011.476
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390249, KAKENHI-PROJECT-22590565, KAKENHI-PROJECT-22590903, KAKENHI-PROJECT-22791042, KAKENHI-PROJECT-23591210, KAKENHI-PROJECT-24390334, KAKENHI-PROJECT-24659640
[Journal Article] Association of ADMA with severity of kidney injury and deckine in kidney function in IgA nephropathy2011
- Author(s)
  Seiya Okuda
- Journal Title
  
  Am J Nephrol
  
  Volume: 33 Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590903
[Journal Article] Tissue level of AGEsis an independent determinant of high sensitive Creactive proteinlevel in HD patients2011
- Author(s)
  Seiay Okuda
- Journal Title
  
  Nephrology
  
  Volume: 18 Pages: 299-302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590903
[Journal Article] Association of asymmetric dimethylarginine with severity ofkidney injury and decline in kidney function in IgA nephropathy.2011
- Author(s)
  Fujimi-Hayashida A, Ueda S, Yamagishi S, Kaida Y, Ando R, Nakayama Y, Fukami K, Okuda S.
- Journal Title
  
  Am J Nephrol.
  
  Volume: 33(1) Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590903
[Journal Article] Association of ADMA with severity of Kidney Injury and Decline in Kidney function in IgA nephropathy2010
- Author(s)
  Seiya Okuda
- Journal Title
  
  American Journal of Nephrology
  
  Volume: 33 Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590903
[Journal Article] New pathways to renal damage : role of ADMA in retarding renal disease progression2010
- Author(s)
  Seiya Okuda
- Journal Title
  
  Journal of Nephrology
  
  Volume: 23 Pages: 377-386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590903
[Journal Article] Interstitial Foxp3-positive T cells may predict renal survival in patients with MPO-ANCA-associated glomerulonephritis2010
- Author(s)
  Seiya Okuda
- Journal Title
  
  Clinical and Experimental Pharmacology and Physiology
  
  Volume: 37 Pages: 879-889
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590903
[Journal Article] New pathways to renal damage: role of ADMA in retarding renal disease progression.2010
- Author(s)
  Ueda S, Yamagishi S, Okuda S.
- Journal Title
  
  J Nephrol.
  
  Volume: 23(4) Pages: 377-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590903
[Journal Article] Involvement of asymmetric dimethylarginine (ADMA) in glomerular capillary loss and sclerosis in a ratmodel of chronic kidney disease (CKD).2009
- Author(s)
  Ueda S, Yamagishi S, Matsumoto Y, Kaida Y, Fujimi-Hayashida A, Koike K, Tanaka H, Fukami K, Okuda S.
- Journal Title
  
  Life Sci.
  
  Volume: 84(23-24) Pages: 853-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590903
[Journal Article]2009
- Author(s)
  Shibata R, Ueda S, Yamagishi S, Kaida Y, Matsumoto Y, Fukami K, Hayashida A, Matsuoka H, Kato S, Kimoto M, Okuda S.
- Journal Title
  
  Nephrol Dial Transplant.
  
  Volume: 24(4) Pages: 1162-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590903
[Journal Article] Administration of pigment epithelium-derived factor (PEDF) reduces proteinuria by suppressing decreased nephrin and increased VEGF expression in the glomeruli of adriamycin-injected rats.2009
- Author(s)
  Fujimura T, Yamagishi S, Ueda S, Fukami K, Shibata R, Matsumoto Y, Kaida Y, Hyayashida A, Koike K, Matsui T, Nakamura K, Okuda S.
- Journal Title
  
  Nephrol Dial Transplant. 24
  
  Pages: 1397-1406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Clinical utility of acarbose, alpha-glucosidase inhibitor on cardiometabolic disorders.2009
- Author(s)
  Yamagishi S, Matsui T, Ueda S, Fukami K, Okuda S.
- Journal Title
  
  Curr Drug Metab. 10
  
  Pages: 159-163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Involvement of asymmetric dimethylarginine (ADMA) in tubulointerstitial ischemia in early phase of diabetic nephropathy.2009
- Author(s)
  Shibata R, Ueda S, Yamagishi S, Kaida Y, Matsumoto Y, Fukami K, Hayashida A, Matsuoka H, Kato S, Kimoto M, Okuda S.
- Journal Title
  
  Nephrol Dial Transplant. 24
  
  Pages: 1162-1169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Involvement of ADMA in tubulointerstitial ischemia in early phase of diabetic nephropathy2009
- Author(s)
  Shibata R, Okuda S
- Journal Title
  
  Nephrol Dial Transplant 24
  
  Pages: 1162-1169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Aqueous humor levels of asymmetric dimethylarginine (ADMA) are positively associated with monocyte chemoattractant protein-1 (MCP-1) in patients with uveitis.2008
- Author(s)
  Yoshida Y, Yamagishi S, Ueda S, Okuda S, Yamakawa R.
- Journal Title
  
  Br J Ophthalmol. 92(1)
  
  Pages: 93-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Role of advanced glycation end products (AGEs) and oxidative stress in diabetic retinopathy.2008
- Author(s)
  Yamagishi S, Ueda S, Matsui T, Nakamura K, Okuda S.
- Journal Title
  
  Curr Pharm Des. 14
  
  Pages: 962-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Pleiotropic effects of atorvastatin of vascular injury in diabetes.2008
- Author(s)
  Yamagishi S, Nakamura K, Matsui T, Ueda S, Fukami K, Okuda S.
- Journal Title
  
  BDL Cholesterol: Targets, Control and Therapy.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Olmesartan blocks advanced glycation end products (AGEs)-induced angiogenesis in vitro by suppressing receptor for AGEs (RAGE) expression2008
- Author(s)
  Yamagishi S, Matsui T, Nakamura K, Inoue H, Takeuchi M, Ueda S, Fukami K, Okuda S, Imaizumi T.
- Journal Title
  
  Microvasc Res 75
  
  Pages: 130-134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Circulating MMP-2 is an independent correlate of proteinuria in patients with chronic kidney disease2008
- Author(s)
  Nagano M, Okuda S
- Journal Title
  
  Am J Nephrol 29
  
  Pages: 109-115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Asymmetric dimethylarginine (ADMA) in diabetic vascular complications2008
- Author(s)
  Yamagishi S, Okuda S
- Journal Title
  
  Curr Pharm Des 14
  
  Pages: 2613-2618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Agents that block advanced glycation end product (AGE)-RAGE (receptor for AGEs)-oxidative stress system: a novel therapeutic strategy for diabetic vascular complications.2008
- Author(s)
  Yamagishi S, Nakamura K, Matsui T, Ueda S, Fukami K, Okuda S.
- Journal Title
  
  Expert Opin Investig Drugs. 17
  
  Pages: 983-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Implication of asymmetric dimethylarginine (ADMA) in endothelial cell growth process in atherosclerosis.2008
- Author(s)
  Ueda S, Yamagishi S, Fukami K, Hayashida A, Kaida Y, Takamiya Y, Okuda S.
- Journal Title
  
  Cell Growth Processes: New Research. (Nova publishers) Chapter IV
  
  Pages: 123-137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Role of AGEs in diabetic nephropathy.2008
- Author(s)
  Fukami K, Yamagishi S, Ueda S, Okuda S.
- Journal Title
  
  Current Pharm Design 14
  
  Pages: 946-952
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Circulating Matrix Metalloproteinase-2 is an independent correlate of proteinuria in patients with chronic kidney disease.2008
- Author(s)
  Nagano M, Fukami K, Yamagishi SI, Ueda S, Kaida Y, Matsumoto T, Yoshimura J, Hazama T, Takamiya Y, Kusumoto T, Gohara S, Tanaka H, Adachi H, Okuda S.
- Journal Title
  
  Am J Nephrol. 29
  
  Pages: 109-115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Role of Asymmetric Dimethylarginine (ADMA) in Diabetic Vascular Complications.2008
- Author(s)
  Yamagishi S, Ueda S, Nakamura K, Matsui T, and Okuda S.
- Journal Title
  
  Curr Pharm Des 14
  
  Pages: 2613-2618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Aqueous humor levels of asymmetric dimethylarginine (ADMA) are correlated with pigment epithelium-derived factor (PEDF) in patients with uveitis.2007
- Author(s)
  Yoshida Y, Yamagishi S, Ueda S, Yoshimura K, Okuda S, Yamakawa R.
- Journal Title
  
  J Int Med Res 35
  
  Pages: 892-895
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] A possible involvement of crosstalk between advanced glycation end products (AGEs) and asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor in accelerated atherosclerosis in diabetes2007
- Author(s)
  Yamagishi S, Ueda S, Okuda S.
- Journal Title
  
  Med Hypotheses 69
  
  Pages: 922-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Olmesartan blocks advanced glycation end product (AGE)-evoked inflammatory reactions in endothelial cells by suppressing reactive oxygen species generation.2007
- Author(s)
  Yamagishi S, Matsui T, Nakamura K, Inoue H, Takeuchi M, Ueda S, Okuda S, Imaizumi T.
- Journal Title
  
  Ophthalmic Res 40
  
  Pages: 10-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Food-derived advanced glycation end products (AGEs): A novel therapeutic target for various disorders.2007
- Author(s)
  Yamagishi S, Ueda S, Okuda S.
- Journal Title
  
  Current Pharmaceutical Design 13
  
  Pages: 2832-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Role of asymmetric dimethylarginine (ADMA) in chronic kidney disease2007
- Author(s)
  Ueda S, Yamagishi S, Matsumoto Y, Okuda S.
- Journal Title
  
  Current Enzyme Inhibition 3
  
  Pages: 284-290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Molecular mechanisms of diabetic nephropathy and its therapeutic intervention.2007
- Author(s)
  Yamagishi S, Fukami K, Ueda S, Okuda S.
- Journal Title
  
  Current Drug Targets 8
  
  Pages: 952-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Pitavastatin inhibits lysophosphatidic acid-induced proliferation and monocyte chemoattractant protein-1 expression in aortic smooth muscle cells by suppressing Rac-1-mediated reactive oxygen species generation.2007
- Author(s)
  Kaneyuki U, Ueda S, Yamagishi SI, Kato S, Fujimura T, Shibata R, Hayashida A, Yoshimura J, Kojiro M, Oshima K, Okuda S.
- Journal Title
  
  Vascul Pharmacol. 46
  
  Pages: 286-292
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Dimethylarginine dimethylaminohydrolase prevents progression of renal dysfunction by inhibiting loss of peritubular capillaries and tubulointerstitial fibrosis in a rat model of chronic kidney disease.2007
- Author(s)
  Matsumoto Y, Ueda S, Yamagishi S, Matsuguma K, Shibata R, Fukami K, Matsuoka H, Imaizumi T, Okuda S.
- Journal Title
  
  J Am Soc Nephrol. 18
  
  Pages: 1525-1533
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Increased levels of IgG antibodies against peptides of the prostate stem cell antigen in the plasma of pancreatic cancer patients.2007
- Author(s)
  Tanaka M, Komatsu N, Terakawa N, Yanagimoto Y, Oka M, Sasada T, Mine T, Gouhara S, Shichijo S, Okuda S, Itoh K.
- Journal Title
  
  Oncol Rep. 18
  
  Pages: 161-166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Asymmetric dimethylarginine (ADMA) and endothelial dysfunction in patients with chronic kidney disease.2007
- Author(s)
  Ueda S, Yamagishi S, Takamiya Y, Kaida Y, Okuda S.
- Journal Title
  
  Research Advances in Nephrology. 1
  
  Pages: 1-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Asymmetric dimethylarginine (ADMA) may be a missing link between cardiovascular disease (CVD) and chronic kidney disease (CKD).2007
- Author(s)
  Ueda S, Yamagishi S, Kaida Y, Okuda S.
- Journal Title
  
  Nephrology 12
  
  Pages: 582-590
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Asymmetric dimethylarginine (ADMA) is a novel emerging risk factor for cardiovascular disease and development of renal injury in chronic kidney disease.2007
- Author(s)
  Ueda S, Yamagishi S, Matsumoto Y, Fukami K, Okuda S.
- Journal Title
  
  Clin Exp Nephrol 11
  
  Pages: 115-121
- NAID
  10024140370
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Adult-onset acute tubulointerstitial nephritis and uveitis with fanconi syndrome. Case report and review of the literature.2007
- Author(s)
  Koike K, Iida S, Usui M, Matsumoto Y, Fukami K, Ueda S, Tamaki K, Kato S, Okuda S.
- Journal Title
  
  Clin Nephrol. 67
  
  Pages: 255-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Nodular Glomerulosclerosis in patients without any manifestation of diabetes mellitus.2007
- Author(s)
  Sanai T, Okuda S, Yoshimitsu T, Oochi N, Kumagai H, Katafuchi R, Harada A, Chihara J, Abe T, Nakamoto M, Hirakata H, Onoyama K, Iida M.
- Journal Title
  
  NEPHROLOGY 12
  
  Pages: 69-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Dimethylarginine dimethylaminohydrolase prevents progression of renal dysfunction by inhibiting loss of peritubular capillaries and tubulointers titial fibrosis in a rat model of chronic kidney disease2007
- Author(s)
  Okuda S, et. al.
- Journal Title
  
  J Am Soc Nephrol 18
  
  Pages: 1525-1533
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Novel therapeutic targets for diabetic nephropathy.2007
- Author(s)
  Fukami K, Yamagishi S, Ueda S, Okuda S.
- Journal Title
  
  Endocr Metab Immune Disord Drug Targets 7
  
  Pages: 83-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Pigment epithelium-derived factor prevents advanced glycation end products-elicited endothelial nitric oxide synthase reduction through its ant-oxidative properties.2007
- Author(s)
  Yamagishi S, Ueda S, Matsui T, Nakamura K, Imaizumi T, Takeuchi M, Okuda S.
- Journal Title
  
  Protein Pept Lett 14
  
  Pages: 832-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Mesangiolytic glomerulopathy after radiotherapy and chemotherapy of gastric lymphoma.2007
- Author(s)
  Yoshimura J, Kato S, Tamaki K, Kohno K, Kaneyuki U, Maeda M, Saikusa-Itoh Y, Hayashida A, Iida S, Suefuji H, Okuda S.
- Journal Title
  
  Intern Med. 46(22)
  
  Pages: 1861-1865
- NAID
  130000075926
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] AGEs activate mesangial TGF-b-Smad signaling via an anguiotensin II type I receptor interaction.2004
- Author(s)
  Fukami K, Ueda S, Yamagishi S, Kato S, Inagami Y, Takeuchi M, Motomiya Y, Bucala R, Iida Y, Tamaki K, Imaizumi T, Cooper ME, Okuda S
- Journal Title
  
  Kidney Int 66
  
  Pages: 2137-2147
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590869
[Journal Article] AGEs activate mesangial TGF-b-Smad signaling via an angiotensin II-type I receptor interaction.2004
- Author(s)
  Okuda.S
- Journal Title
  
  Kidney Int 66
  
  Pages: 2137-2147
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590869
[Journal Article] Role of TGF-b in the progression of renal fibrosis.2003
- Author(s)
  Okuda.S
- Journal Title
  
  Contrin Nephrol 139
  
  Pages: 44-65
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590869
[Journal Article] Regulation of cytokine-induced nitiric oxide synthesis by asymmetric dimethylarginine Role of dimethylarginine dimethylaminohydrolase.2003
- Author(s)
  Ueda S, Kato S, Matsuoka H, Kimoto M, Okuda S, Morimatsu M, Imaizumi T
- Journal Title
  
  Circulation Research 92
  
  Pages: 226-233
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590869
[Journal Article] Role of TGF-b in the progression of renal flbrosis.2003
- Author(s)
  Tamaki K, Okuda S
- Journal Title
  
  Contrin Nephrol 139
  
  Pages: 44-65
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590869
[Journal Article] Risk factors for renal glomerular and vascular changes in an autpsy-based population survey : The Hisayama study.2003
- Author(s)
  Okuda.S
- Journal Title
  
  Kidney Int 63
  
  Pages: 1508-1515
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590869
[Journal Article] Smad protein and TGF-b signaling in vascular smooth muscle cells.2003
- Author(s)
  Ikedo H, Tamaki K, Ueda S, Kato S, Hujii M, TenDuke P, Okuda S
- Journal Title
  
  Int J Mol Med 11
  
  Pages: 645-650
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590869
[Journal Article] Regulation of cytokine-induced nitiric oxide synthesis by asymmetric dimethylarginine Role of dimethylarginine dimethylaminohydrolase.2003
- Author(s)
  Okuda.S
- Journal Title
  
  Circulation Research 92
  
  Pages: 226-233
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590869
[Journal Article] Smad protein and TGF-b signaling in vascular smooth muscle cells.2003
- Author(s)
  Okuda.S
- Journal Title
  
  Int J Mol Med 11
  
  Pages: 645-650
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590869
[Journal Article] Risk factors for renal glomerular and vascular changes in an autpsy-based population survey : The Hisayama study2003
- Author(s)
  Kubo M, Kiyohara Y, Kato I, Tanizaki Y, Katafuchi R, Hirakata H, Okuda S, Tsuneyoshi M, Sueishi K, Fujishima M, Iida M
- Journal Title
  
  Kidney Int 63
  
  Pages: 1508-1515
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590869
[Journal Article] Different effects of 22-oxacalcitrol and calcitriol on the course of experimental chronic renal failure.2002
- Author(s)
  Sanai T, Tokumoto M, Hirano T, Okuda S
- Journal Title
  
  J Lab Clin Med 140
  
  Pages: 242-249
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590869
[Journal Article] Steroid therapy and urinary transforming growth factor-b1 in IgA nephropathy2001
- Author(s)
  Haramaki R, Tamaki K, Fujisawa M, Ikedo H, Haramaki N, Okuda S
- Journal Title
  
  Am J kidney Dis 38
  
  Pages: 1191-1198
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590869
[Journal Article] Steroid therapy and urinary transforming growth factor-b1 in IgA nephropathy2001
- Author(s)
  Okuda.S
- Journal Title
  
  Am J kidney Dis 38
  
  Pages: 1191-1198
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590869
[Journal Article] Caveolae integration of growth factor receptor in mesangial cells and caveolin expression in mesangial proliferative glomerulonephritis.2001
- Author(s)
  Tamai O, Oka N, Kikuchi T, Koda Y, Soejima M, Wada Y, Fujisawa M, Tamaki K, Kawachi H, Shimizu F, Kimura H, Imaizumi T, Okuda S
- Journal Title
  
  Kidney Int 59
  
  Pages: 471-480
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590869
[Journal Article] Ectopic expression of Smad7 inhibits transformationn growth favtor-b responses in vascular smooth muscle cells.2001
- Author(s)
  Kato S, Ueda S, Tamaki K, Fujii M, Miyazono K, PTen Duke, Morimatsu M, Okuda S
- Journal Title
  
  Life Sciences 69
  
  Pages: 2641-2652
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590869
[Journal Article] Depressor effect by exercise training is associated with amelioration of hyperinsulinemia and sympathetic overactivity.2000
- Author(s)
  Kohno K, Matsuoka H, Takenaka K, Miyake Y, Okuda, Nomura G, Imaizumi T
- Journal Title
  
  Internal Medicine 39
  
  Pages: 1013-1019
- NAID
  10006997493
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590869
[Journal Article] Locally-activated renin-angiotensin system associated with TGF-b1 as a major factor for renal injury induced by chronic inhibition of nitric oxide synthase in rats.2000
- Author(s)
  Kashiwagi M, Shinozaki M, Hirakata H, Tamaki K, T Hirano, Tokumota M, Goto H, Okuda S, Fujishima M
- Journal Title
  
  J Am Soc Nephrol 11
  
  Pages: 616-624
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590869
[Journal Article] Role of lipoprotein (a) and TGF-b in atherosclerosis of hemodialysis patients.2000
- Author(s)
  Fujisawa M, Haramaki R, Miyazaki H, Imaizumi T, Okuda S
- Journal Title
  
  J Am Soc Nephrol 11
  
  Pages: 1889-1895
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590869
[Journal Article] Involvement of asymmetric dimethylarginine (ADMA) in glomerular capillary loss and sclerosis in a rat model of chronic kidney disease (CKD)
- Author(s)
  Ueda S, Yamagishi S, Matsumoto Y, Kaida Y, Fujimi-Hayashida A, Koike K, Tanaka H, Fukami K, Okuda S.
- Journal Title
  
  Life Sciences in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590971
[Journal Article] Role of asymmetric dimetylarginine in cardiorenal syndrome.
- Author(s)
  Ueda S, Yamagishi S, Yokoro M, Okuda S.
- Journal Title
  
  Current Pharmaceutical Design
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590903
[Journal Article] Involvement of advanced glycation end product?induced asymmetric dimethylarginine generation in endothelial dysfunction.
- Author(s)
  Ando R, Ueda S, Yamagishi S, Miyazaki H, Kaida Y, Kaifu K, Yokoro M, Nakayama Y, Obara N, Fukami K, Takeuchi M, Okuda S.
- Journal Title
  
  Diabetes & Vascular Disease Research.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590903
[Presentation] MetSにおけるインスリン抵抗性発症についての検討-血管内皮障害因子ADMAの役割の解明-2013
- Author(s)
  岩谷龍治、奥田誠也
- Organizer
  第86回日本内分泌学会学術総会
- Place of Presentation
  仙台
- Year and Date
  2013-04-26
- Data Source
  KAKENHI-PROJECT-22590903
[Presentation] Involvement of DDAH-ADMA Axis in accelerated renal injury in acute ischemia-reperfusion injury2010
- Author(s)
  Seiya Okuda
- Organizer
  American Society of Nephrology
- Place of Presentation
  Denver
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-22590903
[Presentation] Involvement of DDAH-ADMA axis in accelerated renal injury in acute ischemia-reperfusion injury.2010
- Author(s)
  Okuda S, et al.
- Organizer
  American society of nephrology.
- Place of Presentation
  Denver
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-22590903
[Presentation] Possible involvement od albuminuria-alicied ADMA accumulation in accelerated atherosclerosis in CKD2008
- Author(s)
  Kaida Y, Okuda S
- Organizer
  4^<th> International symposium on ADMA
- Place of Presentation
  Bregenz
- Year and Date
  2008-08-29
- Data Source
  KAKENHI-PROJECT-19590971
[Presentation] ADMA in chronic kidney disease2007
- Author(s)
  Okuda, et. al.
- Organizer
  Europian Congress of Dialysis, Transplantation and Nephrology
- Place of Presentation
  バルセロナ
- Year and Date
  2007-07-22
- Data Source
  KAKENHI-PROJECT-19590971

1. TAMAKI Kiyoshi (10312141)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. UEDA Seiji (80322593)

# of Collaborated Projects: 2 results

# of Collaborated Products: 37 results
3. NAKAMURA Kei-ichiro (20172398)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. OHTA Keisuke (00258401)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. HIGASI Ryuhei (70569516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TOGO Akinobu (80569517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YANO Hirohisa (40220206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. WATANABE Hiroshi (90295080)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KUSUKAWA Jingo (30258412)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KIYOKAWA Kensuke (10195399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NISI Akinori (50228144)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. USHIJIMA Kazuo (60136752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. YAMAKI Kouichi (00166597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NAGAT Kensei (50140687)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MARUMO Fumiaki (00050443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SAKAI Osamu (40056560)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. KOIDE Hikaru (80052968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KUROKAWA Kiyoshi (30167390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. ARAKAWA Masaaki (80069012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. TAMAI Osamu (40279170)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. KOHNO Keisuke (70258416)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. KAJIMOTO Hidemi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 甲斐久史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 今泉勉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OKUDA Seiya 奥田 誠也

Research Projects

Research Products

Co-Researchers

ptimization of FIB/SEM techniques ? the novel ultrastructureeanalysis by combination of serial thin ablation and block surface material contrastobservation - for biomedical mesoscale three dimentional structural analysis.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Missing link between metabolic syndrome and chronic kidney disease.?Role of asymmetric dimethylarginine-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ADMA metabolism and microvascular damage in chronic renal diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ROLE OF AND REGULATION OF GROWTH FACTOR TGF-β IN GLOMERULAR LESIONSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

REGULATION OF TGF_ACTIVITY FOR ATTENUATION OF GLOMERULAR LESIONSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

REGULATION OF TGF-β AND ITS SIGNAL MOLECULE, SMAD FOR ATTENUATION OF PERITONEAL FIBROSIS.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

REGULATION OF TGF-β ACTIVITY FOR ATTENUATION OF GLOMERULAR LESIONSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

REGULATION OF TGF-beta ACTIVITY FOR ATTENUATION OF GLOMERULAR LESIONSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

THE PERSISTENT ACTIVATION MECHANISM OF TGF-b IN PROGRESSIVE GLOMERULAR DISEASESPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular Biology of the Kidney-Molecular Analysis of Structure and Function Relationship

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Cell Growth Processes : New research2008

Author(s)

Publisher

Data Source

[Journal Article] Role of asymmetric dimethylargine in cardiorenal syndrome2013

Author(s)

Journal Title

Data Source

[Journal Article] Involvement of advanced glycation end product–induced asymmetric dimethylarginine generation in endothelial dysfunction2013

Author(s)

Journal Title

Data Source

[Journal Article] Inhibition of eNOS phosphorylation mediates endothelial dysfunction in renal failure: new effect of asymmetric dimethylarginine.2012

Author(s)

Journal Title

Data Source

OKUDA Seiya 奥田誠也