OBATA Masanori 小幡雅則

Researcher Number	80158831
Affiliation (based on the past Project Information) *help	2010 – 2011: 山口大学, 大学院・医学系研究科, 講師 2007 – 2008: 山口大学, 大学院・医学系研究科, 講師 2006: Yamaguchi University, Graduate School of Medicine・Bio-Signal Analysis, Associate Professor, 大学院医学系研究科, 講師 2003 – 2005: 山口大学, 医学部, 講師
Review Section/Research Field	Except Principal Investigator Hematology / Hematology / Biological Sciences
Keywords	Except Principal Investigator IL-6 / CD45 / 骨髄腫 / PI 3-kinase / Lyn / PI3-kinase / Galectin-1 / CD45RA / lipid rafts / myeloma … More / 骨髄腫細胞 / 脂質ラフト / PKM2 / 解糖系 / Akt / NF-kB / 未熟型骨髄腫細胞 / signal transduction / CD45R0 / myeloma cells / CD-45 / シグナル伝達 / CD45RO / signal-transducing molecules / IL-6誘導遺伝子 / マイクロアレイ / 質量分析 / 刺激伝達分子 / CD45 isoform / immature myeloma cells / 細胞膜分子動態 / ラフト / CD19 / フォスファターゼ / CD45アイソフォーム / Fox01 / FoxO1 / PPAR / DHEA / 良性M蛋白血症 Less

The Role of the Lyn-PI 3-kinase signaling pathways and PKM2 in the myeloma cell proliferation
- Principal Investigator
  
  ISHIKAWA Hideaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Senri Kinran University
  Yamaguchi University
Analysis of the CD45-Lyn-mediated signaling pathways in theIL-6-induced myeloma cell proliferation
- Principal Investigator
  
  ISHIKAWA Hideaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Yamaguchi University
Analysis of the IL-6-mediated intracellular signaling molecules in myeloma cell growth
- Principal Investigator
  
  ISHIKAWA Hideaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Yamaguchi University
The mechanism of translocation of CD45R0 to lipid rafts in IL-6-induced proliferation of human myeloma cells
- Principal Investigator
  
  KAWANO Michio, 津山尚宏
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Yamaguchi University
前癌病変BMGから骨髄腫への進展に関わるホルモンDHEAの動態とその機能解析
- Principal Investigator
  
  KAWANO Michio
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yamaguchi University
Regulatory mechanism of membrane coreceptors in the proliferation of human myeloma cells
- Principal Investigator
  
  KAWANO Michio
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Yamaguchi University

All 2011 2010 2008

All Journal Article Presentation

[Journal Article] A novel signaling pathway associated with Lyn,PI3-kinase and Akt supports the proliferation of myeloma cells2010
- Author(s)
  Mohd S. Iqbal, Naohiro Tsuyama , Masanori Obata and Hideaki Ishikawa
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: Vol. 392, No. 3 Issue: 3 Pages: 415-420
- DOI
  10.1016/j.bbrc.2010.01.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591039
[Journal Article] 骨髄腫細胞の増殖機構2008
- Author(s)
  石川秀明、小幡雅則
- Journal Title
  
  血液・腫瘍科 57
  
  Pages: 148-150
- Data Source
  KAKENHI-PROJECT-19591115
[Presentation] IL-6-induced phosphorylation of FoxO1 as a target of the PI-3-kinase-Akt pathway in myeloma cells(骨髄腫細胞における IL-6 刺激後 PI3-kinase-Akt 刺激伝達系標的分子 FoxO1 のリン酸化)2011
- Author(s)
  石川秀明、小幡雅則
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-16
- Data Source
  KAKENHI-PROJECT-22591039
[Presentation] Lyn-PI 3-kinase-Akt 刺激伝達系による骨髄腫細胞の増殖機構2010
- Author(s)
  石川秀明、Mohd S. Iqbal、津山尚宏、小幡雅則
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22591039
[Presentation] The IL-6-mediated signaling pathway associated with Lyn,PI 3-kinase and Akt supports the proliferation of human myeloma cells2010
- Author(s)
  Hideaki Ishikawa, Mohd S. Iqbal, Naohiro Tsuyama and Masanori Obata
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-22591039
[Presentation] The Lyn,PI 3-kinase and Akt signaling pathway supports the proliferation of humanmyeloma cells(Lyn-PI3 kinase-Akt 刺激伝達系はヒト骨髄腫細胞の増殖を促進する)2010
- Author(s)
  石川秀明、Mohd S. Iqbal,、津山尚宏、小幡雅則
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-22591039

1. ISHIKAWA Hideaki (40294623)

# of Collaborated Projects: 6 results

# of Collaborated Products: 6 results
2. KAWANO Michio (40161343)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. TSUYAMA Naohiro (10335747)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. MIZUKAMI Yoichi (80274158)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. 石田禎夫 (20305220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OBATA Masanori 小幡 雅則

Research Projects

Research Products

Co-Researchers

The Role of the Lyn-PI 3-kinase signaling pathways and PKM2 in the myeloma cell proliferation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the CD45-Lyn-mediated signaling pathways in theIL-6-induced myeloma cell proliferation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the IL-6-mediated intracellular signaling molecules in myeloma cell growth

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanism of translocation of CD45R0 to lipid rafts in IL-6-induced proliferation of human myeloma cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

前癌病変BMGから骨髄腫への進展に関わるホルモンDHEAの動態とその機能解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulatory mechanism of membrane coreceptors in the proliferation of human myeloma cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A novel signaling pathway associated with Lyn,PI3-kinase and Akt supports the proliferation of myeloma cells2010

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 骨髄腫細胞の増殖機構2008

Author(s)

Journal Title

Data Source

[Presentation] IL-6-induced phosphorylation of FoxO1 as a target of the PI-3-kinase-Akt pathway in myeloma cells(骨髄腫細胞における IL-6 刺激後 PI3-kinase-Akt 刺激伝達系標的分子 FoxO1 の リン酸化)2011

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Lyn-PI 3-kinase-Akt 刺激伝達系によ る骨髄腫細胞の増殖機構2010

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] The IL-6-mediated signaling pathway associated with Lyn,PI 3-kinase and Akt supports the proliferation of human myeloma cells2010

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] The Lyn,PI 3-kinase and Akt signaling pathway supports the proliferation of humanmyeloma cells(Lyn-PI3 kinase-Akt 刺激伝達系はヒト骨髄腫細胞の増殖を促進する)2010

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

OBATA Masanori 小幡雅則

[Presentation] IL-6-induced phosphorylation of FoxO1 as a target of the PI-3-kinase-Akt pathway in myeloma cells(骨髄腫細胞における IL-6 刺激後 PI3-kinase-Akt 刺激伝達系標的分子 FoxO1 のリン酸化)2011

[Presentation] Lyn-PI 3-kinase-Akt 刺激伝達系による骨髄腫細胞の増殖機構2010