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OSADA Hiroyuki  長田 裕之

Researcher Number 80160836
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-3606-4925
External Links
Affiliation (Current) 2023: 静岡県立大学, 薬学部, 特任教授
2023: 国立研究開発法人理化学研究所, 環境資源科学研究センター, ユニットリーダー
Affiliation (based on the past Project Information) *help 2022: 国立研究開発法人理化学研究所, 環境資源科学研究センター, ユニットリーダー
2019 – 2021: 国立研究開発法人理化学研究所, 環境資源科学研究センター, グループディレクター
2015 – 2019: 国立研究開発法人理化学研究所, 環境資源科学研究センター, 副センター長
2016: 理化学研究所, 環境資源科学研究センター ケミカルバイオロジー研究グループ, グループディレクター
2014: 独立行政法人理化学研究所, 環境資源科学研究センター, 副センター長 … More
2014: 独立行政法人理化学研究所, 長田抗生物質研究室, 副センター長
2013: 独立行政法人理化学研究所, 長田抗生物質研究室, 主任研究員
2012 – 2013: 独立行政法人理化学研究所, ケミカルバイオロジー研究領域, 領域長
2012: 独立行政法人理化学研究所, ケミカルバイオロジー研究基盤施設, 施設長
2009: The Institute of Physical and Chemical Research, ケミカルバイオロジー研究基盤施設, 施設長
2007 – 2009: 独立行政法人理化学研究所, 抗生物質研究室, 主任研究員
2004 – 2008: RIKEN, Antibiotics Laboratory, Chief Scientist, Director of Antibiotics Laboratory, 長田抗生物質研究室, 主任研究員
2007: The Institute of Physical and Chemical Research, 長田抗生物質研究室, 主任研究員
2006: 独立行攻法人理化学研究所, 抗生物質研究室, 主任研究員
2005: 独立行政法人理化学研究所, 抗生物質研究室, 主任研究員
2005: 理研, 研究員
2003: 独立行政法人理化学研究所, 抗生物質研究室, 主任研究員
1995 – 2003: 理化学研究所, 抗生物質研究室, 主任研究員
2001: The Institute of Physical and Chemical Research (RIKEN), Chief Investigator, 抗生物質研究室, 主任研究員(研究職)
1997 – 1999: 理化学研究所, 抗生物質, 主任研究員
1996: 理科学研究所, 抗生物質, 主任研究員
1995: 理化学研究所, 主任研究員
1994: 理化学研究所, 抗生物質部, 主任研究員
1992 – 1993: 理化学研究所, 主任研究員
1991: 理化学, 研究所, 研究員
1989 – 1990: 理化学研究所, 研究員 Less
Review Section/Research Field
Principal Investigator
Living organism molecular science / Science and Engineering / Medium-sized Section 38:Agricultural chemistry and related fields / Biological Sciences / Bioproduction chemistry/Bioorganic chemistry / 応用微生物学・応用生物化学 / Bioproduction chemistry/Bioorganic chemistry / Bioorganic chemistry
Except Principal Investigator
Digestive surgery / Biological Sciences / ケミカルバイオロジー / Biomolecular chemistry / Science and Engineering
Keywords
Principal Investigator
ホスファターゼ / VHR / ケミカルバイオロジー / プロテオーム / 細胞周期 / 阻害剤 / cell cycle / RK-682 / 構造活性相関 / プロテオミクス … More / アポトーシス / 生物活性物質 / トリプロスタチン / inhibitor / Curvularia sp. / phoslactomycin / isoavenaciolide / Weel / Cdc2 / 二次代謝産物 / 拮抗阻害 / ホスラクトマイシン / RK-1009 / ホスファトキノン / 癌転移 / 血管新生 / 天然化合物 / フミトレモルジン / 生合成遺伝子 / p38 / リベロマイシン / 2D-DIGE / メチルゲルフィリン / GLO1 / 放線菌 / Epoxyquinol B / 血管内皮細胞 / VEGF / ビオチン / リベロマイシンA / 骨転移 / イエジマライド / V-ATPase / がん細胞 / 破骨細胞 / 金属依存性マトリックス分解酵素 / 化学生物学 / 構造生物学 / バイオプローブ / 蛋白質 / 相互作用 / 受容体 / リガンド / 化合物アレイ / ライブラリー / 低分子化合物 / 結晶構造解析 / 標的分子 / 微生物代謝産物 / フラクションライブラリー / データベース / MPPlot / ChemProteoBase / NPPlot / タキソ-ル / cdc2キナーゼ / アセトフタリジン / 低分子プローブ / 真核細胞 / 微生物産物 / taxol / cdc 2 kinase / tryprostration / acetophthalidin / G1期 / 蛋白質合成阻害 / 新規化合物 / セスキテルペン / トリコテセン / 細胞周期阻害剤 / 微小管 / チューブリン / ピロネチン / ビオチン標識 / チユープリン / サイトカラシン / サイクリン / テルペプチン / ホスミドシン / G1 phase / protein synthesis inhibition / new compound / sesquiterpene / trichotecene / 生合成系 / 脱リン酸化 / Bcl-2 / リン酸化 / 4-isoavenaciolide / Michael付加 / 活性中心 / 分子設計 / テトロン酸 / phosphatase / biosynthesis / apoptosis / dephosphorylation / ユビキチン / エポキシキノール / Wee1 / ubiquitin / epoxytwinol / 生物活性リガンド / 生理活性物質 / 標的同定 / proteome analysis / chemicalbiology / drug target / 植物病原菌 / 共生 / 生物間相互作用 / かび毒 / 植物病害防除 / X線結晶構造解析 / 生合成メカニズム / マイコトキシン / 人工知能 / 抗真菌剤 … More
Except Principal Investigator
ケミカルバイオロジー / リベロマイシン / 多剤耐性克服 / 抗ガン物質 / ustiloxin / 血管新生阻害剤 / PP2A / 磁性体 / 分子標的 / 前立腺がん / 乳がん / 阻害剤 / lavanducyanin / gilvocarcin / leptomycin / 細胞周期特異的阻害剤 / rhizoxin / P-glycoprotein / エトポシド / epiderstatin / ベントシアニン / カプラマイシン誘導体 / ヒストンデアセチラ-ゼ阻害剤 / リゾキシンアシル誘導体 / カンプトテシンアシル誘導体 / 多剤耐性克服機構 / 抗癌抗生物質 / セコスリキサイド / ウスチロキシン / ラジンコ-ル / ギルボカルシンの化学変換 / ホウ素含有化合物 / JS49 / ustiloxin A / reveromycin / radicicol / gilvocarcinの化学変換 / roseophilin / quinolidomicin / malolactomycin / trapoxin / ヒストン脱アセチル化阻害剤 / 抗がん物質 / resorcinin / leptofuranin / アポートシス / curacin A / スピロトリプロスタチン / サイクロトリプロスタチン / di-n-buty1 malate / アデノウイルス癌遺伝子 / チューブリンへの作用 / 抗癌物質 / anguinomycin / arenastatin A / albuside A / 紅花 / UK-1 / acetophthalidin / tryprostatin / cororubicin / menoxymycin / jaspisin / isojaspisin / nostodione A / enamidonin / テロメラーゼ阻害剤 / 海洋生物由来細胞毒物質 / 細胞接着阻害剤 / 神経突起伸長 / アポトーシス誘導物質 / 細胞接着阻害物質 / 細胞周期阻害物質 / 微小管重合 / caspase-3 / DNAポリメラーゼβ阻害物質 / チロシンキナーゼ阻害物質 / 多剤耐性克服物質 / IL-6阻害物質 / TGF-β活性調節物質 / サイトカイン調節物質 / 消化管毒性軽減物質 / 肝細胞癌 / バイスペシフィック抗体 / リベロマイシンA / 動脈基栓療法 / ヘパラナーゼ / VEGF / 血管新生 / がん細胞 / 化学生物学 / アクチン / Hsp60 / Bcl-2 / アポトーシス / 転移 / 血管内皮細胞遊走阻害 / 血管内皮細胞増殖阻害 / がん-間質相互作用 / PP2A阻害剤 / アンドロゲン受容体 / p53 / p21WAF1 / PTHrP(副甲状腺類縁タンパク) / 破骨細胞 / 骨転移 / 間質細胞 / Cuvularol / NK細胞活性化 / 15-deoxyspergualin / 癌増悪化 / 上皮-間質細胞間反応 / がん / STAT3 / NF-κB / 生殖系がん / 阻害剤探索 / 化合物アレイ / 化合物 / スクリーニング / 研究支援 / データベース / 抗がん剤 / 若手支援 / 国際研究者交流 / 遺伝子改変マウス / 病理形態学 / ゲノムコーホート研究 / 次世代分子解析技術 / アカデミア創薬 / ゲノム・エピゲノム解析支援 / 個別化がん予防 / 国際交流 / ATL発症予防 / 分子疫学コーホート研究 / がん化学予防 / ATL発がん機序 / ATL発症リスク / がん分子標的薬剤 / 肝癌 / 超常磁性酸化鉄コロイド / バイスペシフィク抗体 / Hepatocellular carcinoma / ferromagnetic iron-dextran / Bispecific antibody / ゲルダナマイシン / 神経保護作用 / Hsp-90 / 標的同定 / HSP-90 / 2D-DIEG / プロテオーム解析 / 化学コミュニケーション / 分子社会学 / 天然物化学 / 生物活性リガンド / モデル動物作製 / ゲノム編集 / 病理形態解析 / 生理機能解析 / 分子プロファイリング / 分子探索・プロファイリング / 分子探索・ブロファイリング / 行動解析 Less

  • Research Projects

    (30 results)

  • Research Products

    (636 results)

  • Co-Researchers

    (288 People)

  •  人工知能を活用した抗真菌剤の開発研究Principal Investigator

    • Principal Investigator
      長田 裕之
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 38:Agricultural chemistry and related fields
    • Research Institution
      Institute of Physical and Chemical Research

  •  Chemical biology research solves the 3W1H of tenuazonic acidPrincipal Investigator

    • Principal Investigator
      Osada Hiroyuki
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 38:Agricultural chemistry and related fields
    • Research Institution
      Institute of Physical and Chemical Research

  •  プロテオミクスをベースにした化学シグナル解析技術開発Principal Investigator

    • Principal Investigator
      長田 裕之
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Science and Engineering
    • Research Institution
      Institute of Physical and Chemical Research

  •  Frontiers in Chemical Communications

    • Principal Investigator
      Kakeya Hideaki
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Science and Engineering
    • Research Institution
      Kyoto University

  •  Advanced Animal Model Support

    • Principal Investigator
      INOUE Jun-ichiro, 今井 浩三
    • Principal Investigator(Support)
      IMAI Kohzoh
    • Project Period (FY)
      2016 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas ― Platforms for Advanced Technologies and Research Resources
    • Research Institution
      The University of Tokyo

  •  Creation of bioactive compounds by activation and engineering of microbial secondary metabolite biosynthetic genesPrincipal Investigator

    • Principal Investigator
      Osada Hiroyuki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Bioorganic chemistry
    • Research Institution
      Institute of Physical and Chemical Research

  •  Molecular mechanism of neuroprotective activity of geldanamycin

    • Principal Investigator
      NISHIKAWA Toshio
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Biomolecular chemistry
    • Research Institution
      Nagoya University

  •  小分子化合物を用いた生殖系がん細胞におけるＮＦ－κＢとＳＴＡＴ３の機能解析Host Researcher

    • Host Researcher
      長田 裕之
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for JSPS Fellows
    • Research Field
      ケミカルバイオロジー
    • Research Institution
      Institute of Physical and Chemical Research

  •  Construction of the database of microbial products and its application studyPrincipal Investigator

    • Principal Investigator
      OSADA Hiroyuki
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      The Institute of Physical and Chemical Research

  •  Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas

    • Principal Investigator
      IMAI Kohzoh, 中村 祐輔
    • Project Period (FY)
      2010 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Research Institution
      The University of Tokyo

  •  Development of an information-intensive basis for cancer chemotherapy

    • Principal Investigator
      YAMORI Takao
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Japanese Foundation For Cancer Research

  •  Drug discovery research based on the molecular mechanisms of tumor growth and metastasisPrincipal Investigator

    • Principal Investigator
      OSADA Hiroyuki
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research

  •  微生物由来低分子バイオプローブの開発と細胞内情報伝達因子のプロテオーム解析Principal Investigator

    • Principal Investigator
      長田 裕之
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Living organism molecular science
    • Research Institution
      The Institute of Physical and Chemical Research

  •  Chemical proteomics to reveal interaction between chemicals and proteins at angstrom levelPrincipal Investigator

    • Principal Investigator
      OSADA Hiroyuki
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Creative Scientific Research
    • Research Institution
      The Institute of Physical and Chemical Research

  •  Development of small-molecular-bioprobes and proteomic analyses of signal transduction factors.Principal Investigator

    • Principal Investigator
      OSADA Hiroyuki
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Living organism molecular science
    • Research Institution
      RIKEN

  •  がん増殖環境修飾物質の研究Principal Investigator

    • Principal Investigator
      長田 裕之, 石塚 雅章
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research
      Microbial Chemistry Research Foundation

  •  Chemical biology study on protein phosphatases and their specific inhibitors.Principal Investigator

    • Principal Investigator
      OSADA Hiroyuki
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      RIKEN

  •  新規天然制癌物質の探索とその作用機序の解明

    • Principal Investigator
      石塚 雅章
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Microbial Chemistry Research Foundation

  •  New transcatheter arterial embolization therapy for unresectable hepatocellular carcinoma using ferromagnetic iron-dextran reagents combined with anticancer drug and bispecific antibody

    • Principal Investigator
      SUZUKI Masanori
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Tohoku University

  •  デュアルスペシフィックホスファターゼの阻害剤開発と機能探索Principal Investigator

    • Principal Investigator
      長田 裕之
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The Institute of Physical and Chemical Research

  •  デュアルスペシフィックホスファターゼの阻害剤開発と機能探索Principal Investigator

    • Principal Investigator
      長田 裕之
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The Institute of Physical and Chemical Research

  •  肝癌を標的とした抗癌剤・バイスペシフィク抗体磁性複合体の磁界にによる肝内分布制御

    • Principal Investigator
      SUZUKI Masanori
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Tohoku University

  •  Isolation and mechanism study of cell cycle inhibitors from microbial metabolites.Principal Investigator

    • Principal Investigator
      OSADA Hiroyuki
    • Project Period (FY)
      1997 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      RIKEN

  •  Development of bioprobes which regulate mammalian cell cyclePrincipal Investigator

    • Principal Investigator
      OSADA Hiroyuki
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      応用微生物学・応用生物化学
    • Research Institution
      The Institte of Physical and Chemical Research

  •  新規天然抗がん物質の探索

    • Principal Investigator
      瀬戸 治男
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo

  •  新規構造を有する天然物由来抗癌物質に関する研究

    • Principal Investigator
      瀬戸 治男
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo

  •  新規構造を有する天然物由来抗癌物質に関する研究

    • Principal Investigator
      瀬戸 治男
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo

  •  新規構造を有する天然物由来抗癌物質に関する研究

    • Principal Investigator
      瀬戸 治男
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo

  •  天然物由来制癌物質の探索とその化学的誘導に関する研究

    • Principal Investigator
      瀬戸 治男
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo

  •  天然物由来制癌物質の探索とその化学的誘導に関する研究

    • Principal Investigator
      瀬戸 治男
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo

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All Journal Article Presentation Book Patent

  • [Book] 医薬品開発におけるオミクス解析技術-ゲノム・トランスクリプトーム・プロテオーム・メタポローム-「薬剤標的分子同定を目的としたプロテオーム解析の手法」2020
    • Author(s)
      室井誠、小川直子、長田裕之
    • Total Pages
      181
    • Publisher
      情報機構
    • Data Source
      KAKENHI-PROJECT-16H06276

  • [Book] 医薬品開発におけるオミクス解析技術 ～ゲノム・トランスクリプトーム・プロテオーム・メタボローム～2020
    • Author(s)
      鎌田　真由美, 奥野　恭史, 山田　弘, 森田　英利, 田丸　浩, 伊藤　昌可, 林崎　良英, 飯塚　朋代, 小林　巧, 池尾　一穂, 中岡　慎治, 松田　史生, 室井　誠, 小川　直子, 長田　裕之, 三浦　信明, 杉本　昌弘, 中山　泰宗, 三枝　淳, 松本　光晴, 久保田　浩行, 金井　弥栄, 津田　昇, 鈴木　孝昌
    • Total Pages
      181
    • Publisher
      情報機構
    • ISBN
      9784865021844
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Book] ケミカルバイオロジー化合物集 -研究展開のヒント -2018
    • Author(s)
      日本学術振興会ケミカルバイオロジー第189委員会」編 　編集長：長田 裕之
    • Publisher
      株式会社 オーム社
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Book] Bioprobes, 2nd edition2017
    • Author(s)
      Osada H (ed)
    • Total Pages
      384
    • Publisher
      Springer
    • ISBN
      9784431565277
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Book] Bioprobes2017
    • Author(s)
      Osada, Hiroyuki (Ed.)
    • Total Pages
      384
    • Publisher
      Springer Japan
    • ISBN
      9784431565277
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Book] 現代化学　特集：微生物生合成系を活用した化合物ライブラリーの構築（「ケミカルバイオロジー　-小さな分子で生命現象を探る- 」）2016
    • Author(s)
      長田 裕之
    • Total Pages
      80
    • Publisher
      東京化学同人
    • Data Source
      KAKENHI-PROJECT-221S0001

  • [Book] CSJ Current Review 生物活性分子のケミカルバイオロジー　標的同定と作用機構2015
    • Author(s)
      室井 誠, 長田 裕之
    • Total Pages
      200
    • Publisher
      （株）化学同人
    • Data Source
      KAKENHI-PROJECT-221S0001

  • [Book] Methods in Molecular Biology 1263: Chapter 3 "Construction and application of a photo-cross-linked chemical array. " (「Chemical Biology Methods and protocols」)2015
    • Author(s)
      Kondoh Y, Honda K, Osada H
    • Total Pages
      333
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-221S0001

  • [Book] 特集・制がん剤の分子標的スクリーニング成績 「化学療法基盤情報支援班」報告-制がん候補物質のスクリーニング成績・第14報『癌と化学療法オンライン』2013
    • Author(s)
      矢守隆夫, 上原至雅, 深澤秀輔, 吉田稔, 井本正哉, 清宮啓之, 水上民夫, 川田学, 長田裕之, 松浦正明.
    • Publisher
      癌と化学療法社
    • Data Source
      KAKENHI-PROJECT-221S0001

  • [Book] 特集・制がん剤の分子標的スクリーニング成績 「化学療法基盤情報支援班」報告‐制がん候補物質のスクリーニング成績・第15報『癌と化学療法オンライン』2013
    • Author(s)
      矢守隆夫, 上原至雅, 深澤秀輔, 吉田稔, 井本正哉, 清宮啓之, 馬島哲夫, 水上民夫, 川田学, 長田裕之, 旦慎吾, 松浦正明, 掛谷秀昭, 冨田章弘.
    • Publisher
      癌と化学療法社
    • Data Source
      KAKENHI-PROJECT-221S0001

  • [Book] 特集・制がん剤の分子標的スクリーニング成績 化学療法基盤情報支援班報告-制がん候補物質のスクリーニング成績・第14報-2013
    • Author(s)
      矢守隆夫, 上原至雅, 深澤秀輔, 吉田稔, 井本正哉, 清宮啓之, 水上民夫, 川田学, 長田裕之, 松浦正明.
    • Publisher
      癌と化学療法社
    • Data Source
      KAKENHI-PROJECT-221S0001

  • [Book] 次世代がん戦略研究Update がん基盤生物学 -革新的シーズ育成に向けて- （執筆タイトル：リン酸化依存性タンパク質間相互作用阻害物質の探索と抗がん剤への展開）2013
    • Author(s)
      渡邉信元, 長田裕之.
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-221S0001

  • [Book] 特集・制がん剤の分子標的スクリーニング成績 化学療法基盤支援活動報告-制がん候補物質のスクリーニング成績・第15報2013
    • Author(s)
      矢守隆夫, 上原至雅, 深澤秀輔, 吉田稔, 井本正哉, 清宮啓之, 馬島哲夫, 水上民夫, 川田学, 長田裕之, 旦慎吾, 松浦正明, 掛谷秀昭, 冨田章弘
    • Publisher
      癌と化学療法社
    • Data Source
      KAKENHI-PROJECT-221S0001

  • [Book] 特集・制がん剤の分子標的スクリーニング成績「化学療法基盤情報支援班」報告-制がん候補物質のスクリーニング成績・第13報-2010
    • Author(s)
      矢守隆夫、上原至雅、吉田稔、井本正哉、清宮啓之、水上民夫、川田学、長田裕之、松浦正明、深澤秀輔
    • Total Pages
      158
    • Publisher
      癌と化学療法
    • Data Source
      KAKENHI-PROJECT-17012025

  • [Book] 癌と化学療法(特集・制がん剤の分子標的スクリーニング成績「化学療法基盤情報支援班」報告-制がん候補物質のスクリーニング成績・第13報-, 37)2010
    • Author(s)
      矢守隆夫, 上原至雅, 吉田稔, 井本正哉, 清宮啓之, 水上民夫, 川田学, 長田裕之, 松浦正明, 深澤秀輔
    • Data Source
      KAKENHI-PROJECT-17012025

  • [Book] Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications(Hiroyuki Osada 編, Chemical biology based on small molecule-protein interaction)2009
    • Author(s)
      Osada H.
    • Total Pages
      297
    • Publisher
      Wiley
    • Data Source
      KAKENHI-PROJECT-17012025

  • [Book] Protein Targeting with Small Molecules.2009
    • Author(s)
      Osada, H. Ed.
    • Total Pages
      289
    • Publisher
      A John Wiley, Sons, Inc.
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Book] Protein Targeting with Small Molecules2009
    • Author(s)
      長田裕之 Ed.
    • Total Pages
      289
    • Publisher
      A John Wiley & Sons, Inc
    • Data Source
      KAKENHI-PROJECT-17012025

  • [Book] Protein Targeting with Small Molecules2009
    • Author(s)
      Osada, H.Ed.
    • Total Pages
      289
    • Publisher
      A John Wiley & Sons, Inc.
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Book] Protein Targeting with Small Molecules2009
    • Author(s)
      Osada, H.Ed.
    • Total Pages
      289
    • Publisher
      A John Wiley & Sons, Inc.
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Book] がん化学療法の標的細胞周期「がん化学療法・分子標的治療update(西條&西尾編)」2009
    • Author(s)
      渡辺信元、長田裕之
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Book] 化合物アレイを用いた抗がん剤探索系がん分子標的治療研究実践マニュアル2009
    • Author(s)
      清水史郎、宮崎功、本田香織、近藤恭光、長田裕之、金芳堂
    • Publisher
      日本がん分子標的治療学会
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Book] 入門ケミカルバイオロジー2008
    • Author(s)
      長田 裕之, 他
    • Total Pages
      189
    • Publisher
      オーム社
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Book] 入門ケミカルバイオロジー2008
    • Author(s)
      長田裕之
    • Total Pages
      189
    • Publisher
      オーム社
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Book] がんの分子標的治療 第II部 13 「ケミカルゲノミクス」2008
    • Author(s)
      長田 裕之
    • Total Pages
      441
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Book] がんの分子標的治療 第II部 13「ケミカルゲノミクス」2008
    • Author(s)
      長田裕之
    • Total Pages
      441
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Book] 浸潤と転移-1タンパク質分解酵素と糖分解酵素「がんの分子標的治療(鶴尾隆編)」2008
    • Author(s)
      清水史郎、長田裕之
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Book] ケミカルゲノミクス「がんの分子標的治療(鶴尾隆編)」2008
    • Author(s)
      長田裕之
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Book] 入門ケミカルバイオロジー2008
    • Author(s)
      長田裕之, 他
    • Total Pages
      189
    • Publisher
      オーム社
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Book] 特集・制がん剤の分子標的スクリーニング成績 「化学療法基盤情報支援班」報告-制がん候補物質のスクリーニング成績・第12報-.2007
    • Author(s)
      矢守隆夫, 上原至雅, 吉田稔, 井本正哉, 清宮啓之, 水上民夫, 川田学, 長田裕之, 松浦正明.
    • Publisher
      癌と化学療法
    • Data Source
      KAKENHI-PROJECT-17012025

  • [Book] 癌と化学療法(特集・制がん剤の分子標的スクリーニング成績 「化学療法基盤情報支援班」報告-制がん候補物質のスクリーニング成績・第12報-, 34)2007
    • Author(s)
      矢守隆夫, 上原至雅, 吉田稔, 井本正哉, 清宮啓之, 水上民夫, 川田学, 長田裕之, 松浦正明
    • Data Source
      KAKENHI-PROJECT-17012025

  • [Book] 文部科学省科学研究費補助金によるがん研究に係る特定領域研究 II「化学療法基盤情報支援班」報告2007
    • Author(s)
      矢守隆夫, 上原至雅, 吉田稔, 井本正哉, 清宮啓之, 水上民夫, 川田学, 長田裕之, 松浦正明
    • Publisher
      癌と化学療法(印刷中)
    • Data Source
      KAKENHI-PROJECT-17012025

  • [Journal Article] Identification of a small molecule that enhances ferroptosis via inhibition of ferroptosis suppressor protein 1 (FSP1).2022
    • Author(s)
      Yoshioka H, Kawamura T, Muroi M, Kondoh Y, Honda K, Kawatani M, Aono H, Waldmann H, Watanabe N, Osada H.
    • Journal Title

      ACS Chem Biol

      Volume: 17 Pages: 483-491

    • DOI

      10.1021/acschembio.2c00028

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-19K05744, KAKENHI-PROJECT-20K05857, KAKENHI-PROJECT-16H06276

  • [Journal Article] Elucidation of structure-activity relationship of humulanolides and identification of humulanolide analog as a novel HSP90 inhibitor.2022
    • Author(s)
      Saegusa J, Osada Y, Miura K, Sasazawa Y, Ogura A, Takao KI, Simizu S.
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 60 Pages: 128589-128589

    • DOI

      10.1016/j.bmcl.2022.128589

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K15571, KAKENHI-PUBLICLY-20H05340, KAKENHI-PROJECT-21H01943, KAKENHI-PROJECT-21K07425, KAKENHI-PROJECT-16H06276

  • [Journal Article] Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations2021
    • Author(s)
      Kobayashi H, Hatakeyama H, Nishimura H, Yokota M, Suzuki S, Tomabechi Y, Shirouzu M, Osada H, Mimaki M, Goto YI, Yoshida M.
    • Journal Title

      Nature Chemical Biology

      Volume: 17 Pages: 335-343

    • DOI

      10.1038/s41589-020-00676-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-19H05640, KAKENHI-PROJECT-19K16728

  • [Journal Article] Identification of a small-molecule glucose transporter inhibitor, glutipyran, that inhibits cancer cell growth.2021
    • Author(s)
      Kawatani M, Aono H, Hiranuma S, Shimizu T, Muroi M, Ogawa N, Ohishi T, Ohba SI, Kawada M, Nogawa T, Okano A, Hashizume D, Osada H.
    • Journal Title

      ACS Chem Biol

      Volume: 16 Pages: 1576-1586

    • DOI

      10.1021/acschembio.1c00480

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K05744, KAKENHI-PROJECT-20K05857, KAKENHI-PROJECT-20K05858, KAKENHI-PROJECT-16H06276

  • [Journal Article] N-Acetyl-α-hydroxy-β-oxotryptamine, a racemic natural product isolated from Streptomyces sp. 80H647.2021
    • Author(s)
      Lopez Julius Adam V.、Nogawa Toshihiko、Futamura Yushi、Aono Harumi、Hashizume Daisuke、Osada Hiroyuki
    • Journal Title

      J Antibiot

      Volume: ahead of online

    • DOI

      10.1038/s41429-021-00420-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K05858, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18H03945

  • [Journal Article] Proteomics-based target identification of natural products affecting cancer metabolism.2021
    • Author(s)
      Muroi M, Osada H.
    • Journal Title

      J Antibiot

      Volume: 74 Pages: 639-650

    • DOI

      10.1038/s41429-021-00437-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K05857, KAKENHI-PROJECT-16H06276

  • [Journal Article] Dihydropyriculol produced by Pyricularia oryzae inhibits the growth of Streptomyces griseus.2021
    • Author(s)
      Furuyama Yuuki、Motoyama Takayuki、Nogawa Toshihiko、Kamakura Takashi、Osada Hiroyuki
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 85 Pages: 1290-1293

    • DOI

      10.1093/bbb/zbab021

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07742, KAKENHI-PROJECT-20K05820, KAKENHI-PROJECT-20K05858, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18H03945

  • [Journal Article] Reveromycin A, a novel acid-seeking agent, ameliorates bone destruction and tumor growth in multiple myeloma2021
    • Author(s)
      Keiichiro Watanabe、Ariunzaya Bat-Erdene、Hirofumi Tenshin、Qu Cui、Jumpei Teramachi、Masahiro Hiasa、Asuka Oda、Takeshi Harada、Hirokazu Miki、Kimiko Sogabe、Masahiro Oura、Ryohei Sumitani、Yukari Mitsui、Itsuro Endo、Eiji Tanaka、Makoto Kawatani、Hiroyuki Osada、Toshio Matsumoto、Masahiro Abe
    • Journal Title

      Haematologica

      Volume: 106 Pages: 1172-1177

    • DOI

      10.3324/haematol.2019.244418

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08329, KAKENHI-PROJECT-19K05744, KAKENHI-PROJECT-19K22719, KAKENHI-PROJECT-17KK0169, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-17H05104, KAKENHI-PROJECT-20K18784

  • [Journal Article] Does local injection of reveromycin A inhibit tooth movement without causing systemic side effects?2021
    • Author(s)
      Kako S, Tabuchi M, Miyazawa K, Tanaka M, Minamoto C, Asano Y, Kimura F, Aoki Y, Sato T, Kawatani M, Osada H, Maeda H, Goto S.
    • Journal Title

      European Journal of Orthodontics

      Volume: - Pages: 658-664

    • DOI

      10.1093/ejo/cjaa067

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18K09870, KAKENHI-PROJECT-19K05744

  • [Journal Article] Identification of dihydroorotate dehydrogenase inhibitors-indoluidins-that inhibit cancer cell growth.2021
    • Author(s)
      Kawatani M., Aono H., Shimizu T., Ohkura S., Hiranuma S., Muroi M., Ogawa N., Ohishi T., Ohba S., Kawada M., Yamazaki K., Dan S., Osada H.
    • Journal Title

      ACS Chem. Biol.

      Volume: 16 Pages: 2570-2580

    • DOI

      10.1021/acschembio.1c00625

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K05744, KAKENHI-PROJECT-20K05857, KAKENHI-PROJECT-16H06276

  • [Journal Article] Dutomycin induces autophagy and apoptosis by targeting the serine protease Inhibitor SERPINB6.2021
    • Author(s)
      Jang M, Hara S, Kim GH, Kim SM, Son S, Kwon M, Ryoo IJ, Seo H, Kim MJ, Kim ND, Soung NK, Kwon YT, Kim BY, Osada H, Jang JH, Ko SK, Ahn JS.
    • Journal Title

      ACS Chem Biol

      Volume: 16 Pages: 360-370

    • DOI

      10.1021/acschembio.0c00889

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Journal Article] Identification of the kinanthraquinone biosynthetic gene cluster by expression of an atypical response regulator2021
    • Author(s)
      Takao R, Sakai K, Koshino H, Osada H, Takahashi S.
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 85 Pages: 714-721

    • DOI

      10.1093/bbb/zbaa082

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-17H06412, KAKENHI-PUBLICLY-19H04666, KAKENHI-PROJECT-18H03945

  • [Journal Article] A new peptaibol, RK-026A, from the soil fungus Trichoderma sp. RK10-F026 by culture condition-dependent screening.2021
    • Author(s)
      Rawa Mira Syahfriena Amir、Nogawa Toshihiko、Okano Akiko、Futamura Yushi、Nakamura Takemichi、Wahab Habibah A、Osada Hiroyuki
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 85 Pages: 69-76

    • DOI

      10.1093/bbb/zbaa051

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K05858, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18H03945

  • [Journal Article] Controlling the production of phytotoxin pyriculol in Pyricularia oryzae by aldehyde reductase.2021
    • Author(s)
      Furuyama Yuuki、Motoyama Takayuki、Nogawa Toshihiko、Hayashi Toshiaki、Hirota Hiroshi、Kiyota Hiromasa、Kamakura Takashi、Osada Hiroyuki
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 85 Pages: 126-133

    • DOI

      10.1093/bbb/zbaa035

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07742, KAKENHI-PROJECT-20K05820, KAKENHI-PROJECT-20K05858, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18H03945, KAKENHI-PROJECT-19H02958

  • [Journal Article] Discovery of a σ1 receptor antagonist by combination of unbiased cell painting and thermal proteome profiling2021
    • Author(s)
      Wilke J, Kawamura T, Xu H, Brause A, Friese A, Metz M, Schepmann D, Wunsch B, Artacho-Cordon A, Nieto FR, Watanabe N, Osada H, Ziegler S, Waldmann H.
    • Journal Title

      Cell Chemical Biology

      Volume: - Pages: 1-7

    • DOI

      10.1016/j.chembiol.2021.01.009

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412, KAKENHI-PUBLICLY-19H05302

  • [Journal Article] Productivity and bioactivity of enokipodins A-D of Flammulina rossica and Flammulina velutipes.2020
    • Author(s)
      Tabuchi Akiko、Fukushima-Sakuno Emi、Osaki-Oka Kumiko、Futamura Yushi、Motoyama Takayuki、Osada Hiroyuki、Ishikawa Noemia Kazue、Nagasawa Eiji、Tokimoto Keisuke
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 84 Pages: 876-886

    • DOI

      10.1080/09168451.2020.1714421

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07742, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18H03945

  • [Journal Article] Peanut skin extract ameliorates the symptoms of type 2 diabetes mellitus in mice by alleviating inflammation and maintaining gut microbiota homeostasis.2020
    • Author(s)
      Xiang L, Wu Q, Osada H, Yoshida M, Pan W, Qi J
    • Journal Title

      Aging (Albany NY)

      Volume: 12 Pages: 13991-14018

    • DOI

      10.18632/aging.103521

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-19H05640

  • [Journal Article] Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana.2020
    • Author(s)
      Sako Kaori、Futamura Yushi、Shimizu Takeshi、Matsui Akihiro、Hirano Hiroyuki、Kondoh Yasumitsu、Muroi Makoto、Aono Harumi、Tanaka Maho、Honda Kaori、Shimizu Kenshirou、Kawatani Makoto、Nakano Takeshi、Osada Hiroyuki、Noguchi Ko、Seki Motoaki
    • Journal Title

      Sci Rep

      Volume: 10 Pages: 8691-8691

    • DOI

      10.1038/s41598-020-65614-9

    • NAID

      120006876594

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K01970, KAKENHI-PROJECT-19K05744, KAKENHI-PROJECT-20K05857, KAKENHI-PROJECT-18K14441, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-18H02140, KAKENHI-PROJECT-18K05366

  • [Journal Article] Discovery of 3-cinnamamido-N-substituted benzamides as potential antimalarial agents.2020
    • Author(s)
      Liu H, Futamura Y, Wu H, Ishiyama A, Zhang T, Shi T, Zheng Q, Iwatsuki M, Omura S, Zou H, Osada H.
    • Journal Title

      Med Chem

      Volume: -

    • DOI

      10.2174/1573406416666200817160708

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Journal Article] Miclxin, a novel MIC60 inhibitor, induces apoptosis via mitochondrial stress in beta-catenin mutant tumor cells2020
    • Author(s)
      Ikeda H, Muroi M, Kondoh Y, Ishikawa S, Kakeya H, Osada H, Imoto M
    • Journal Title

      ACS Chem. Biol

      Volume: 15 Pages: 2195-2204

    • DOI

      10.1021/acschembio.0c00381

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K05857, KAKENHI-PLANNED-17H06401, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-18H02099, KAKENHI-PROJECT-18K05366, KAKENHI-PROJECT-16H06276

  • [Journal Article] Identification of a small compound targeting PKM2-regulated signaling using 2D gel electrophoresis-based proteome-wide CETSA.2020
    • Author(s)
      Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba SI, Kawada M, Osada H.
    • Journal Title

      Cell Chemical Biology

      Volume: 27 Pages: 1-11

    • DOI

      10.1016/j.chembiol.2019.11.010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08693, KAKENHI-PROJECT-19K05744, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-17K07783, KAKENHI-PROJECT-19K15717, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20K05857

  • [Journal Article] Alteration of tooth movement by reveromycin A in osteoprotegerin-deficient mice.2020
    • Author(s)
      Minamoto C., Miyazawa K., Tabuchi M., Tanaka H., Mizuno M., Yoshizako M., Torii Y., Tamaoka Y., Asano Y., Kawatani M., Osada H., Maeda H., and Goto S.
    • Journal Title

      American Journal of Orthodontics and Dentofacial Orthopedics

      Volume: 157 Pages: 680-689

    • DOI

      10.1016/j.ajodo.2019.04.037

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K05744, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18K09870

  • [Journal Article] Interaction between goniothalamin and peroxisomal multifunctional enzyme type 2 triggering endoplasmic reticulum stress.2020
    • Author(s)
      Sophonnithiparasert T, Aruksakunwong O, Tashiro E, Kondoh Y, Muroi M, Osada H, Imoto M, Watanapokasin R
    • Journal Title

      Heliyon

      Volume: 6

    • DOI

      10.1016/j.heliyon.2020.e05200

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K05732, KAKENHI-PROJECT-20K05857, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-18K05366

  • [Journal Article] CRM646-A, a fungal metabolite, induces nucleus condensation by increasing Ca2+ levels in rat 3Y1 fibroblast cells.2020
    • Author(s)
      Asami Y, Kim SO, Jang JP, Ko SK, Kim BY, Osada H, Jang JH, Ahn JS.
    • Journal Title

      J Microbiol Biotechnol

      Volume: 30 Pages: 31-37

    • DOI

      10.4014/jmb.1908.08043

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Journal Article] Induction of secondary metabolite production by hygromycin B and identification of the 1233A biosynthetic gene cluster with a self-resistance gene.2020
    • Author(s)
      Kato Sho、Motoyama Takayuki、Uramoto Masakazu、Nogawa Toshihiko、Kamakura Takashi、Osada Hiroyuki
    • Journal Title

      J Antibiot

      Volume: － Pages: 475-479

    • DOI

      10.1038/s41429-020-0295-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07742, KAKENHI-PROJECT-18H03945, KAKENHI-PROJECT-17K07784, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-19H02958

  • [Journal Article] Biosynthetic gene cluster identification and biological activity of lucilactaene from Fusarium sp. RK97-94.2020
    • Author(s)
      Kato Sho、Motoyama Takayuki、Futamura Yushi、Uramoto Masakazu、Nogawa Toshihiko、Hayashi Toshiaki、Hirota Hiroshi、Tanaka Akira、Takahashi-Ando Naoko、Kamakura Takashi、Osada Hiroyuki
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 84 Pages: 1303-1307

    • DOI

      10.1080/09168451.2020.1725419

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07742, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18H03945, KAKENHI-PROJECT-17K07784

  • [Journal Article] Unique features of the ketosynthase domain in a non-ribosomal peptide synthetase-polyketide synthase hybrid enzyme, tenuazonic acid synthetase 12020
    • Author(s)
      Yun Choong-Soo、Nishimoto Kazuki、Motoyama Takayuki、Shimizu Takeshi、Hino Tomoya、Dohmae Naoshi、Nagano Shingo、Osada Hiroyuki
    • Journal Title

      J Biol Chem

      Volume: 295 Pages: 11602-11612

    • DOI

      10.1074/jbc.ra120.013105

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07742, KAKENHI-PROJECT-18K05420, KAKENHI-PROJECT-20K05820, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18H03945, KAKENHI-PROJECT-18K06156

  • [Journal Article] Uncovering hidden sesquiterpene biosynthetic pathway through expression boost area-mediated productivity enhancement in basidiomycete.2020
    • Author(s)
      Asai Shihori、Tsunematsu Yuta、Masuya Takahiro、Otaka Junnosuke、Osada Hiroyuki、Watanabe Kenji
    • Journal Title

      J Antibiot

      Volume: 73 Pages: 721-728

    • DOI

      10.1038/s41429-020-0355-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K05866, KAKENHI-PROJECT-20K15457, KAKENHI-PLANNED-16H06449, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18H03945

  • [Journal Article] Heterologous expression of the biosynthetic gene cluster for verticilactam and identification of analogues.2020
    • Author(s)
      Nogawa Toshihiko、Terai Atsutaka、Amagai Keita、Hashimoto Junko、Futamura Yushi、Okano Akiko、Fujie Manabu、Satoh Noriyuki、Ikeda Haruo、Shin-ya Kazuo、Osada Hiroyuki、Takahashi Shunji
    • Journal Title

      J Nat Prod

      Volume: 83 Pages: 3598-3605

    • DOI

      10.1021/acs.jnatprod.0c00755

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K05858, KAKENHI-PLANNED-17H06412, KAKENHI-PUBLICLY-19H04666, KAKENHI-PROJECT-18H03945

  • [Journal Article] Pesticide treatment reduces hydrophobic pollutant contamination in Cucurbita pepo through competitive binding to major latex-like proteins.2020
    • Author(s)
      Fujita K, Kondoh Y, Honda K, Haga Y, Osada H, Matsumura C, Inui H.
    • Journal Title

      Environmental Pollution

      Volume: 266 Pages: 115179-115179

    • DOI

      10.1016/j.envpol.2020.115179

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-18K05366

  • [Journal Article] Identification of a selective RelA inhibitor based on DSE-FRET screening methods.2020
    • Author(s)
      Shiroma Y, Fujita G, Yamamoto T, Takahashi RU, Kumar A, Zhang KYJ, Ito A, Osada H, Yoshida M, Tahara H.
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 21 Pages: 9150-9150

    • DOI

      10.3390/ijms21239150

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-19H05640

  • [Journal Article] ゲノム創薬の潮流2020
    • Author(s)
      長田 裕之
    • Journal Title

      腫瘍内科

      Volume: 25 Pages: 2-8

    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Journal Article] A novel GSK3 inhibitor that promotes self-renewal in mouse embryonic stem cells.2020
    • Author(s)
      Kobayashi H, Nishimura H, Kudo N, Osada H, Yoshida M.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 84 Pages: 2113-2120

    • DOI

      10.1080/09168451.2020.1789445

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-19H05640

  • [Journal Article] Identification of target protein for bio-active small molecule using photo-cross linked beads and MALDI-TOF mass spectrometry.2020
    • Author(s)
      Suvarna Kruthi、Honda Kaori、Muroi Makoto、Kondoh Yasumitsu、Watanabe Nobumoto、Osada Hiroyuki
    • Journal Title

      Bio-protocol

      Volume: 10

    • DOI

      10.21769/bioprotoc.3517

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K05366, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PUBLICLY-19H05302, KAKENHI-PROJECT-17K07783

  • [Journal Article] Measurement of ATPase activity of valosin-containing protein/p97.2020
    • Author(s)
      Suvarna Kruthi、Honda Kaori、Muroi Makoto、Kondoh Yasumitsu、Osada Hiroyuki、Watanabe Nobumoto
    • Journal Title

      Bio-protocol

      Volume: 10

    • DOI

      10.21769/bioprotoc.3516

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K05366, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PUBLICLY-19H05302, KAKENHI-PROJECT-17K07783

  • [Journal Article] β-carboline chemical signals induce reveromycin production through a LuxR family regulator in Streptomyces sp. SN-5932020
    • Author(s)
      Panthee S, Kito N, Hayashi T, Shimizu T, Ishikawa J, Hamamoto H, Osada H, Takahashi S.
    • Journal Title

      Scientific Reports

      Volume: 10 Pages: 10230-10230

    • DOI

      10.1038/s41598-020-66974-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-17H06412, KAKENHI-PUBLICLY-19H04666, KAKENHI-PROJECT-18H03945

  • [Journal Article] Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics.2020
    • Author(s)
      16)Kawamura, T., Futamura, Y., Shang, E., Muroi, M., Janning, P., Ueno, M., Wilke, J., Takeda, S., Kondoh, Y., Ziegler, S., Watanabe, N., Waldmann, H., Osada, H.
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 84 Pages: 2484-2490

    • DOI

      10.1080/09168451.2020.1812375

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K05857, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PUBLICLY-19H05302, KAKENHI-PROJECT-18K05366

  • [Journal Article] An integrated screening system for the selection of exemplary substrates for natural and engineered cytochrome P450s.2019
    • Author(s)
      Kanoh Naoki, Kawamata-Asano Ayano, Suzuki Kana, Takahashi Yusuke, Miyazawa Takeshi, Nakamura Takemichi, Moriya Takashi, Hirano Hiroyuki, Osada Hiroyuki, Iwabuchi Yoshiharu, Takahashi Shunji
    • Journal Title

      Sci Rep

      Volume: 9 Pages: 18023-18023

    • DOI

      10.1038/s41598-019-54473-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08262, KAKENHI-PLANNED-17H06412, KAKENHI-PUBLICLY-19H04666

  • [Journal Article] Comparison of microplate- and bottle-based methods to age yeast for chronological life span assays2019
    • Author(s)
      Kwong MMY, Lee JW, Samian MR, Watanabe N, Osada H, Ong EBB.
    • Journal Title

      Journal of Microbiological Methods

      Volume: 167 Pages: 105743-105743

    • DOI

      10.1016/j.mimet.2019.105743

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412, KAKENHI-PUBLICLY-19H05302

  • [Journal Article] Identification of a chemical modulator of EZH2-mediated silencing by cell-based high-throughput screening assay.2019
    • Author(s)
      Murashima Akihiro、Shinjo Keiko、Katsushima Keisuke、Onuki Tetsuo、Kondoh Yasumitsu、Osada Hiroyuki、Kagaya Noritaka、Shin-ya Kazuo、Kimura Hiroshi、Yoshida Minoru、Murakami Shingo、Kondo Yutaka.
    • Journal Title

      J. Biochem.

      Volume: - Pages: 1-10

    • DOI

      10.1093/jb/mvz007

    • NAID

      40021952184

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H03582, KAKENHI-PROJECT-17K14995, KAKENHI-PROJECT-18K05366, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-26221204

  • [Journal Article] 2-Sulfonylpyrimidines Target the Kinesin HSET via Cysteine Alkylation2019
    • Author(s)
      Forster T, Shang E, Shimizu K, Sanada E, Scholermann B, Huebecker B, Hahne G, Lopez-Alberca MP, Janning P, Watanabe N, Sievers S, Giordanetto F, Shimizu T, Ziegler S, Osada H, Waldmann H.
    • Journal Title

      European Journal of Organic Chemistry

      Volume: 2019 Pages: 5486-5496

    • DOI

      10.1002/ejoc.201900586

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412, KAKENHI-PUBLICLY-19H05302

  • [Journal Article] 3β,23,28-Trihydroxy-12-oleanene 3β-caffeate from Desmodium sambuense-induced neurogenesis in PC12 cells mediated by ER stress and BDNF-TrkB signaling pathways.2019
    • Author(s)
      Cheng L, Muroi M, Cao S, Bian L, Osada H, Xiang L, Qi J
    • Journal Title

      Mol Pharm

      Volume: 16 Pages: 1423-1432

    • DOI

      10.1021/acs.molpharmaceut.8b00939

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07783, KAKENHI-PLANNED-17H06412

  • [Journal Article] Abscisic acid derivatives with different alkyl chain lengths activate distinct abscisic acid receptor subfamilies.2019
    • Author(s)
      Yoshida Kazuko、Kondoh Yasumitsu、Iwahashi Fukumatsu、Nakano Takeshi、Honda Kaori、Nagano Eiki、Osada Hiroyuki
    • Journal Title

      ACS Chem Biol

      Volume: 14 Pages: 1964-1971

    • DOI

      10.1021/acschembio.9b00453

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K05366, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-18H03945

  • [Journal Article] β-carboline biomediators induce reveromycin production in Streptomyces sp. SN-5932019
    • Author(s)
      Panthee S., Takahashi S.*, Hayashi T., Shimizu T, and Osada H.
    • Journal Title

      Scientific Reports

      Volume: 9 Pages: 5802-5802

    • DOI

      10.1038/s41598-019-42268-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-17H05455, KAKENHI-PROJECT-16H04905, KAKENHI-PLANNED-17H06412, KAKENHI-PUBLICLY-19H04666, KAKENHI-PROJECT-18H03945

  • [Journal Article] Stereocomplementary chemoenzymatic Pictet-Spengler reactions for formation of rare azepino-indole frameworks: Discovery of antimalarial compounds.2019
    • Author(s)
      Cai Y, Shao N, Xie H, Futamura Y, Panjikar S, Liu H, Zhu H, Osada H, Zou H.
    • Journal Title

      ACS Catal

      Volume: 9 Pages: 7443-7448

    • DOI

      10.1021/acscatal.9b01628

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Journal Article] Construction of a potato fraction library for the investigation of functional secondary metabolites.2019
    • Author(s)
      Nogawa T, Futamura Y, Okano A, Suto M, Nakamura J, Ishihara K, Osada H.
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 83 Pages: 65-75

    • DOI

      10.1080/09168451.2018.1525273

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07784, KAKENHI-PLANNED-17H06412

  • [Journal Article] Synthesis of All Stereoisomers of RK460 and Evaluation of Their Activity and Selectivity as Abscisic Acid Receptor Antagonists2019
    • Author(s)
      Mikame Yu、Yoshida Kazuko、Hashizume Daisuke、Hirai Go、Nagasawa Kazuo、Osada Hiroyuki、Sodeoka Mikiko
    • Journal Title

      Chemistry European Journal

      Volume: 25 Pages: 3496-3500

    • DOI

      10.1002/chem.201806056

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-18H04417, KAKENHI-PROJECT-18H02097, KAKENHI-PROJECT-16K13094, KAKENHI-PROJECT-18H03945, KAKENHI-PUBLICLY-18H04387, KAKENHI-PROJECT-16K18662

  • [Journal Article] Cucurbitacin B induces neurogenesis in PC12 cells and protects memory in APP/PS1 mice.2019
    • Author(s)
      Li J, Sun K, Muroi M, Gao L, Chang YT, Osada H, Xiang L, Qi J.
    • Journal Title

      J Cell Mol Med

      Volume: 23 Pages: 6283-6294

    • DOI

      10.1111/jcmm.14514

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Journal Article] Mechanism of action of prethioviridamide, an anticancer ribosomally synthesized and post-translationally modified peptide with a polythioamide structure2019
    • Author(s)
      Takase Shohei、Kurokawa Rumi、Kondoh Yasumitsu、Honda Kaori、Suzuki Takehiro、Kawahara Teppei、Ikeda Haruo、Dohmae Naoshi、Osada Hiroyuki、Shin-ya Kazuo、Kushiro Tetsuo、Yoshida Minoru、Matsumoto Ken
    • Journal Title

      ACS Chem Biol

      Volume: 14 Pages: 1819-1828

    • DOI

      10.1021/acschembio.9b00410

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K05366, KAKENHI-PLANNED-16H06447, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-19H05640, KAKENHI-PROJECT-26221204

  • [Journal Article] Discovery and applications of nucleoside antibiotics beyond polyoxin.2019
    • Author(s)
      Osada H.
    • Journal Title

      J Antibiot

      Volume: 72 Pages: 853-854

    • DOI

      10.1038/s41429-019-0237-1

    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Journal Article] Structure and biological activity of Metarhizin C, a stereoisomer of BR-050 from Tolypocladium album RK17-F0007.2019
    • Author(s)
      Nogawa T., Kawatani M., Okano A., Futamura Y., Aono H., Shimizu T., Kato N., Kikuchi H., and Osada H.
    • Journal Title

      The Journal of Antibiotics

      Volume: 72 Pages: 996-1000

    • DOI

      10.1038/s41429-019-0229-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K05744, KAKENHI-PLANNED-17H06412, KAKENHI-PUBLICLY-19H04665, KAKENHI-PROJECT-17H01472, KAKENHI-PROJECT-18H03945, KAKENHI-PROJECT-17K01970, KAKENHI-PROJECT-17K07784

  • [Journal Article] A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell-accelerated fibroblast migration2019
    • Author(s)
      Suvarna K, Honda K, Muroi M, Kondoh Y, Osada H, Watanabe N
    • Journal Title

      Journal of Biological Chemistry

      Volume: 294 Pages: 2988-2996

    • DOI

      10.1074/jbc.ra118.004741

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07783, KAKENHI-PROJECT-18K05366, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-18H03945

  • [Journal Article] Nocardamin glucuronide, a new member of the ferrioxamine siderophores isolated from the ascamycin-producing strain Streptomyces sp. 80H6472019
    • Author(s)
      Lopez JAV, Nogawa T, Futamura Y, Shimizu T, Osada H.
    • Journal Title

      The Journal of Antibiotics

      Volume: 72 Pages: 991-995

    • DOI

      10.1038/s41429-019-0217-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18H03945, KAKENHI-PROJECT-17K07784

  • [Journal Article] Cucurbitacin B induces neurogenesis in PC12 cells and protects memory in APP/PS1 mice.2019
    • Author(s)
      Farooq U, Pan Y, Lin Y, Wang Y, Osada H, Xiang L, Qi J.
    • Journal Title

      J Cell Mol Med

      Volume: 2019 Pages: 5459862-5459862

    • DOI

      10.1155/2019/5459862

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-17K07783

  • [Journal Article] Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments.2019
    • Author(s)
      Simpkins SW, Deshpande R, Nelson J, Li SC, Piotrowski JS, Ward HN, Yashiroda Y, Osada H, Yoshida M, Boone C, Myers CL
    • Journal Title

      Nat. Protoc.

      Volume: 14 Pages: 415-440

    • DOI

      10.1038/s41596-018-0099-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06411, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-26221204

  • [Journal Article] Induction of nectriapyrone biosynthesis in the rice blast fungus Pyricularia oryzae by disturbance of the two-component signal transduction system2019
    • Author(s)
      Motoyama Takayuki、Nogawa Toshihiko、Hayashi Toshiaki、Hirota Hiroshi、Osada Hiroyuki
    • Journal Title

      Chembiochem

      Volume: 20 Pages: 693-700

    • DOI

      10.1002/cbic.201800620

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07742, KAKENHI-PROJECT-17K07784, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18H03945

  • [Journal Article] A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition2019
    • Author(s)
      Subedi A, Muroi M, Futamura Y, Kawamura T, Aono H, Nishi M, Ryo A, Watanabe N, Osada H.
    • Journal Title

      FEBS Letters

      Volume: 593 Pages: 763-776

    • DOI

      10.1002/1873-3468.13361

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K01970, KAKENHI-PROJECT-17K07783, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18H03945, KAKENHI-PROJECT-18K09000, KAKENHI-PUBLICLY-19H05302

  • [Journal Article] Bioenergetic and proteomic profiling to screen small molecule inhibitors that target cancer metabolisms2019
    • Author(s)
      Futamura Y, Muroi M, Aono H, Kawatani M, Hayashida M, Sekine T, Nogawa T, Osada H.
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

      Volume: 1867 Pages: 28-37

    • DOI

      10.1016/j.bbapap.2018.06.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K01970, KAKENHI-PROJECT-17K07783, KAKENHI-PROJECT-17K07784, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18H03945, KAKENHI-PROJECT-16K01941

  • [Journal Article] YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A0012019
    • Author(s)
      Yamamoto K, Futamura Y, Uson-Lopez RA, Aono H, Shimizu T, Osada H.
    • Journal Title

      The Journal of Antibiotics

      Volume: 72 Pages: 986-990

    • DOI

      10.1038/s41429-019-0239-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18H03945, KAKENHI-PROJECT-17K01970

  • [Journal Article] Anti-angiogenesis effects induced by octaminomycins A and B against HUVECs.2018
    • Author(s)
      Jang JP, Han JM, Jung HJ, Osada H, Jang JH, Ahn JS.
    • Journal Title

      J Microbiol Biotechnol

      Volume: 28 Pages: 1332-1338

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Journal Article] Biosynthesis and Structure-Activity Relationship Studies of Okaramines That Target Insect Glutamate-Gated Chloride Channels2018
    • Author(s)
      Kato Naoki、Furutani Shogo、Otaka Junnosuke、Noguchi Akira、Kinugasa Kiyomi、Kai Kenji、Hayashi Hideo、Ihara Makoto、Takahashi Shunji、Matsuda Kazuhiko、Osada Hiroyuki
    • Journal Title

      ACS Chem. Biol.

      Volume: 13 Pages: 561-566

    • DOI

      10.1021/acschembio.7b00878

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-17H05454, KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-17H01472, KAKENHI-PROJECT-16H04905

  • [Journal Article] Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion.2018
    • Author(s)
      Wilke J, Kawamura T, Watanabe N, Osada H, Ziegler S, Waldmann H.
    • Journal Title

      Bioorg Med Chem

      Volume: 26 Pages: 1453-1461

    • DOI

      10.1016/j.bmc.2017.11.009

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445, KAKENHI-PLANNED-17H06412

  • [Journal Article] Wakodecalines A and B, new decaline metabolites isolated from a fungus Pyrenochaetopsis sp. RK10-F058.2018
    • Author(s)
      Nogawa T, Kato N, Shimizu T, Okano A, Futamura Y, Takahahi S, Osada H
    • Journal Title

      J. Antibiot.

      Volume: 71 Pages: 123-128

    • DOI

      10.1038/ja.2017.103

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07784, KAKENHI-PUBLICLY-17H05454, KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-16H04905

  • [Journal Article] Identification and Characterization of Small Molecule Compounds That Modulate Trichothecene Production by Fusarium graminearum2018
    • Author(s)
      Maeda Kazuyuki、Ichikawa Hinayo、Nakajima Yuichi、Motoyama Takayuki、Ohsato Shuichi、Kanamaru Kyoko、Kobayashi Tetsuo、Nishiuchi Takumi、Osada Hiroyuki、Kimura Makoto
    • Journal Title

      ACS Chemical Biology

      Volume: 13 Pages: 1260-1269

    • DOI

      10.1021/acschembio.8b00044

    • NAID

      120006523680

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07742, KAKENHI-PROJECT-18H03945, KAKENHI-PROJECT-16K07623

  • [Journal Article] Functional characterization of recombinant snake venom rhodocytin : rhodocytin mutant blocks CLEC-2/podoplanin-dependent platelet aggregation and lung metastasis.2018
    • Author(s)
      Sasaki T, Shirai T, Tsukiji N, Otake S, Tamura S, Ichikawa J, Osada M, Satoh K, Ozaki Y, Suzuki-Inoue K.
    • Journal Title

      J Thromb Haemost

      Volume: 16 Issue: 5 Pages: 960-972

    • DOI

      10.1111/jth.13987

    • NAID

      130008080766

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K19910, KAKENHI-PROJECT-17K16185, KAKENHI-PROJECT-17H05073, KAKENHI-PROJECT-16H06276

  • [Journal Article] Structures and Synthesis of Hitoyopodins: Bioactive Aromatic Sesquiterpenoids Produced by the Mushroom Coprinopsis cinerea2018
    • Author(s)
      Otaka J, Shimizu T, Futamura Y, Hashizume D, Osada H.
    • Journal Title

      Organic Letters

      Volume: 20 Pages: 6294-6297

    • DOI

      10.1021/acs.orglett.8b02788

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18H03945

  • [Journal Article] Identification of an asexual reproduction inducer of phytopathogenic and toxigenic Fusarium.2018
    • Author(s)
      Jianhua Qi, Lihong Cheng, Yujuan Sun, Yushi Hirata, Naoki Ushida, Zhonghua Ma, Hiroyuki Osada, Toshio Nishikawa, Lan Xiang.
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 57 Pages: 8100-8104

    • DOI

      10.1002/anie.201803329

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06406, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-16H04915

  • [Journal Article] Catenulisporolides, glycosylated triene macrolides from the chemically underexploited actinomycete Catenulispora species.2018
    • Author(s)
      Son S., Hong Y.S., Futamura Y., Jang M., Lee J.K., Heo K.T., Ko S.K., Lee J.S., Takahashi S., Osada H., Jang J.H., Ahn J.S.
    • Journal Title

      Org Lett

      Volume: 20 Pages: 7234-7238

    • DOI

      10.1021/acs.orglett.8b03160

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05455, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-16H04905

  • [Journal Article] Pentaminomycins A and B, hydroxyarginine-containing cyclic pentapeptides from Streptomyces sp. RK88-1441.2018
    • Author(s)
      Jang J.-P., Hwang G.J., Kwon M.C., Ryoo I.-J., Jang M., Takahashi S., Ko S.K., Osada H., Jang J.H., and Ahn J.S.
    • Journal Title

      J Nat Prod

      Volume: 81 Pages: 806-810

    • DOI

      10.1021/acs.jnatprod.7b00882

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05455, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-16H04905

  • [Journal Article] Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions.2018
    • Author(s)
      Simpkins SW, Nelson J, Deshpande R, Li SC, Piotrowski JS, Wilson EH, Gebre AA, Safizadeh H, Okamoto R, Yoshimura M, Costanzo M, Yashiroda Y, Ohya Y, Osada H, Yoshida M, Boone C, Myers CL
    • Journal Title

      PLoS Comput. Biol.

      Volume: 14

    • DOI

      10.1371/journal.pcbi.1006532

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06411, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-26221204

  • [Journal Article] Identification of a small-molecule ligand of β-arrestin1 as an inhibitor of stromal fibroblast cell migration accelerated by cancer cells2018
    • Author(s)
      Suvarna K, Honda K, Kondoh Y, Osada H, Watanabe N.
    • Journal Title

      Cancer Medicine

      Volume: 7 Pages: 883-893

    • DOI

      10.1002/cam4.1339

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-18K05366, KAKENHI-PLANNED-18H05503

  • [Journal Article] Catalytic enantioselective synthesis of a pyrrolizidine-alkaloid-inspired compound collection with antiplasmodial activity.2018
    • Author(s)
      Jia ZJ, Takayama H, Futamura Y, Aono H, Bauer JO, Strohmann C, Antonchick AP, Osada H, Waldmann H.
    • Journal Title

      J Org Chem

      Volume: 83 Pages: 7033-7041

    • DOI

      10.1021/acs.joc.7b03202

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Journal Article] Functional annotation of chemical libraries across diverse biological processes2017
    • Author(s)
      Piotrowski JS, Li SC, Deshpande R.......Shirahige K,......Boone C.
    • Journal Title

      Nat. Chem. Biol.

      Volume: 13 Pages: 1286-1286

    • DOI

      10.1038/nchembio.2436

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-INTERNATIONAL-15K21761, KAKENHI-PLANNED-15H05976, KAKENHI-PLANNED-17H06411, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-26221204, KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-15H04402, KAKENHI-PROJECT-15H04483, KAKENHI-PROJECT-15K07376

  • [Journal Article] Identification of a trichothecene production inhibitor by chemical array and library screening using trichodiene synthase as a target protein2017
    • Author(s)
      3.Maeda K., Nakajima Y., Motoyama T., Kondoh Y., Kawamura T., Kanamaru K., Ohsato S., Nishiuchi T., Yoshida M., Osada H., Kobayashi T., Kimura M.
    • Journal Title

      Pestic. Biochem. Physiol.

      Volume: 138 Pages: 1-7

    • DOI

      10.1016/j.pestbp.2017.03.006

    • NAID

      120006523682

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K07623, KAKENHI-PROJECT-17K07742, KAKENHI-PROJECT-26221204, KAKENHI-PROJECT-15H02445

  • [Journal Article] Allantopyrone a activates Keapl-Nrf2 pathway and protects PC12 cells from oxidative stress-induced cell death.2017
    • Author(s)
      Uesugi S, Muroi M, Kondoh Y, Shiono Y, Osada H, Kimura KI
    • Journal Title

      Journal of Antibiotics

      Volume: 70 Issue: 4 Pages: 429-434

    • DOI

      10.1038/ja.2016.99

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15J04501, KAKENHI-PROJECT-26350976, KAKENHI-PROJECT-17K07783, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-16H04910, KAKENHI-PROJECT-16H06276

  • [Journal Article] Octaminomycins A and B, cyclic octadepsipeptides active against Plasmodium falciparum2017
    • Author(s)
      Jang JP, Nogawa T, Futamura Y, Shimizu T, Hashizume D, Takahashi S, Jang JH, Ahn JS, Osada H
    • Journal Title

      J. Nat. Prod.

      Volume: 80 Pages: 134-140

    • DOI

      10.1021/acs.jnatprod.6b00758

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-26450148, KAKENHI-PROJECT-17K07784, KAKENHI-PROJECT-16H04905

  • [Journal Article] Identification and structure-activity relationship of purine derivatives as novel MTH1 inhibitors2017
    • Author(s)
      Kumar A, Kawamura T, Kawatani M, Osada H, Zhang KY
    • Journal Title

      Chem. Biol. Drug Des.

      Volume: - Pages: 862-869

    • DOI

      10.1111/cbdd.12909

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-15K16563, KAKENHI-PROJECT-16K01941, KAKENHI-PLANNED-17H06412

  • [Journal Article] Phenotypic identification of a novel autophagy inhibitor chemotype targeting lipid kinase VPS34.2017
    • Author(s)
      Robke I., Laraia L, Carnero Corrales MA, Konstantinidis G, Muroi M, Richters A, Winzker M, Engbring T, Tomassi S, Watanabe N, Osada H, Rauh D, Waldmann H, Wu YW, Engel J
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 56 Issue: 28 Pages: 8153-8157

    • DOI

      10.1002/anie.201703738

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07783, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-16H06276

  • [Journal Article] Opantimycin A, a new metabolite isolated from Streptomyces sp. RK88-1355.2017
    • Author(s)
      Nogawa T, Okano A, Lim CL, Futamura Y, Shimizu T, Takahashi S, Ibrahim D, Osada H
    • Journal Title

      J Antibiot

      Volume: 70 Pages: 222-225

    • DOI

      10.1038/ja.2016.113

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Journal Article] Hitoyol A and B, Two Norsesquiterpenoids from the Basidiomycete Coprinopsis cinerea2017
    • Author(s)
      Otaka Junnosuke、Hashizume Daisuke、Masumoto Yui、Muranaka Atsuya、Uchiyama Masanobu、Koshino Hiroyuki、Futamura Yushi、Osada Hiroyuki
    • Journal Title

      Org Lett

      Volume: 19 Pages: 4030-4033

    • DOI

      10.1021/acs.orglett.7b01784

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K07724, KAKENHI-PUBLICLY-17H05430, KAKENHI-PROJECT-17H06173, KAKENHI-PROJECT-15H02445

  • [Journal Article] Structure-activity relationships of terpendole E and its natural derivatives2017
    • Author(s)
      Nagumo Y, Hayashi T, Hirota H, Aono H, Kawatani M, Osada H, Usui T
    • Journal Title

      ChemistrySelect

      Volume: 2 Pages: 1533-1536

    • DOI

      10.1002/slct.201602015

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-26450109, KAKENHI-PROJECT-26430140, KAKENHI-PLANNED-17H06412

  • [Journal Article] Trachyspic acid 19-butyl ester, a new inhibitor of Plk1 polo box domain-dependent recognition from uncharacterized fungus RKGS-F26842017
    • Author(s)
      Nogawa T, Ogita N, Futamura Y, Negishi S, Watanabe N, Osada H
    • Journal Title

      The Journal of Antibiotics

      Volume: 70 Pages: 705-707

    • DOI

      10.1038/ja.2016.167

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-26450148, KAKENHI-PROJECT-17K07784

  • [Journal Article] Regulatory Mechanism of Mycotoxin Tenuazonic Acid Production in Pyricularia oryzae2017
    • Author(s)
      Yun CS, Motoyama T, Osada H
    • Journal Title

      ACS Chem Biol

      Volume: 12 Pages: 2270-2274

    • DOI

      10.1021/acschembio.7b00353

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07742, KAKENHI-PROJECT-15H02445

  • [Journal Article] Development of a terpenoid-production platform in streptomyces reveromyceticus SN-593.2017
    • Author(s)
      Khalid A, Takagi H, Panthee S, Muroi M, Chappell J, Osada H, Takahashi S
    • Journal Title

      ACS Synthctic Biology

      Volume: 6 Issue: 12 Pages: 233-2349

    • DOI

      10.1021/acssynbio.7b00249

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07783, KAKENHI-PUBLICLY-17H05455, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-16H04905, KAKENHI-PROJECT-16H06276

  • [Journal Article] RK-144171, a new benadrostin derivative produced by Streptomyces sp. RK88-14412017
    • Author(s)
      Jang JP, Takahashi S, Futamura Y, Nogawa T, Jang JH, Ahn JS, Osada H
    • Journal Title

      The Journal of Antibiotics

      Volume: 70 Pages: 102-104

    • DOI

      10.1038/ja.2016.65

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-26450148, KAKENHI-PROJECT-17K07784

  • [Journal Article] Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host2017
    • Author(s)
      4.Amagai, K., Ikeda, H., Hashimoto, J., Kozone, I., Izumikawa, M., Kudo, F., Eguchi, T., Nakamura, T., Osada, H., Takahashi, S., Shin-ya
    • Journal Title

      Sci Rep

      Volume: 7 Pages: 3382-3382

    • DOI

      10.1038/s41598-017-03308-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-16H06447, KAKENHI-PLANNED-16H06451, KAKENHI-PUBLICLY-17H05434, KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-16H04905

  • [Journal Article] Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells2017
    • Author(s)
      Shikata Y, Kiga M, Futamura Y, Aono H, Inoue H, Kawada M, Osada H, and Imoto M.
    • Journal Title

      Cancer Science

      Volume: 印刷中 Pages: 772-784

    • DOI

      10.1111/cas.13172

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H03116, KAKENHI-PROJECT-15K06888, KAKENHI-PROJECT-16H06276

  • [Journal Article] Structures and biological activities of azaphilones produced by Penicillium sp. KCB11A109 from a ginseng field2016
    • Author(s)
      Son S, Ko SK, Kim JW, Lee JK, Jang M, Ryoo IJ, Hwang GJ, Kwon MC, Shin KS, Futamura Y, Hong YS, Oh H, Kim BY, Ueki M, Takahashi S, Osada H, Jang JH, Ahn JS.
    • Journal Title

      Phytochemistry

      Volume: 122 Pages: 154-164

    • DOI

      10.1016/j.phytochem.2015.12.008

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Journal Article] An overproduction of astellolides induced by genetic disruption of chromatin remodeling factors in Aspergillus oryzae.2016
    • Author(s)
      Shinohara Y, Kawatani M, Futamura Y, Osada H, Koyama Y
    • Journal Title

      J. Antibiot.

      Volume: 69 Pages: 4-8

    • DOI

      10.1038/ja.2015.73

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-16K01941

  • [Journal Article] New Cyclic Lipopeptides of the Iturin Class Produced by Saltern-Derived Bacillus sp. KCB14S0062016
    • Author(s)
      Son S, Ko SK, Jang M, Kim JW, Kim GS, Lee JK, Jeon ES, Futamura Y, Ryoo IJ, Lee JS, Oh H, Hong YS, Kim BY, Takahashi S, Osada H, Jang JH, Ahn JS.
    • Journal Title

      Mar Drugs

      Volume: 14

    • DOI

      10.3390/md14040072

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Journal Article] Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ.2016
    • Author(s)
      Kondoh Y, Honda K, Hiranuma S, Hayashi T, Shimizu T, Watanabe N, Osada H
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 29881-29881

    • DOI

      10.1038/srep29881

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-26350976

  • [Journal Article] Identification of a novel sesquiterpene biosynthetic machinery involved in astellolide biosynthesis.2016
    • Author(s)
      Shinohara Y, Takahashi S, Osada H, Koyama Y
    • Journal Title

      Sci Rep.

      Volume: 6 Pages: 32865-32865

    • DOI

      10.1038/srep32865

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-16H04905

  • [Journal Article] Proteomic profiling reveals that collismycin A is an iron chelator.2016
    • Author(s)
      Kawatani M, Muroi M, Wada A, Inoue G, Futamura Y, Aono H, Shimizu K, Shimizu T, Igarashi Y, Takahashi-Ando N, Osada H.
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 38385-38385

    • DOI

      10.1038/srep38385

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-16K01941, KAKENHI-PROJECT-16H06276

  • [Journal Article] RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis.2016
    • Author(s)
      Kakeya, H., Kaida, D., Sekiya, H., Nagai, K., Yoshida, M., and Osada, H.
    • Journal Title

      J. Antibiot.

      Volume: 69 Pages: 121-123

    • DOI

      10.1038/ja.2015.94

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26221204, KAKENHI-PROJECT-15H02445

  • [Journal Article] Unantimycin A, a new neoantimycin analogue isolated from a microbial metabolite fraction library.2016
    • Author(s)
      Lim CL., Nogawa T., Okano A., Futamura Y., Kawatani M., Takahashi S. Ibrahim D., Osada H.
    • Journal Title

      J Antibiot

      Volume: AOP Pages: 456-458

    • DOI

      10.1038/ja.2015.124

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26450148, KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-16K01941

  • [Journal Article] High-throughput screening identifies artesunate as selective inhibitor of cancer stemness: Involvement of mitochondrial metabolism.2016
    • Author(s)
      Subedi A, Futamura Y, Nishi M, Ryo A, Watanabe N, Osada H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 477 Pages: 737-742

    • DOI

      10.1016/j.bbrc.2016.06.128

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Journal Article] Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival.2016
    • Author(s)
      Kawamura T, Kawatani M, Muroi M, Kondoh Y, Futamura Y, Aono H, Tanaka M, Honda K, Osada H.
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 26521-26521

    • DOI

      10.1038/srep26521

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-26350976, KAKENHI-PROJECT-15K16563, KAKENHI-PROJECT-16K01941, KAKENHI-PROJECT-16H06276

  • [Journal Article] Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 12016
    • Author(s)
      Ursu A, Illich DJ, Takemoto Y, Porfetye AT, Zhang M, Brockmeyer A, Janning P, Watanabe N, Osada H, Vetter IR, Ziegler S, Schöler HR, Waldmann H
    • Journal Title

      Cell Chem Biol

      Volume: 23 Pages: 494-507

    • DOI

      10.1016/j.chembiol.2016.02.015

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Journal Article] Small molecules that target phosphorylation dependent protein-protein interaction.2016
    • Author(s)
      Watanabe N, Osada H
    • Journal Title

      Bioorg Med. Chem.

      Volume: 印刷中 Pages: 30171-30177

    • DOI

      10.1016/j.bmc.2016.03.023

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-24510320

  • [Journal Article] Stachybotrysin, an osteoclast differentiation inhibitr from the marine-derived fungus Stachybotrys so. KCB13F0132016
    • Author(s)
      Kim JW, Ko SK, Kim HM, Kim GH, Son S, Kim GS, Hwang GJ, Jeon ES, Shin KS, Ryoo IJ, Hong YS, Oh H, Lee KH, Soung NK, Hashizume D, Nogawa T, Takahashi S, Kim BY, Osada H, Jang JH, Ahn JS
    • Journal Title

      Journal of Natural Products

      Volume: 79 Pages: 2703-2708

    • DOI

      10.1021/acs.jnatprod.6b00641

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-26450148

  • [Journal Article] Discovery of novel selenium derivatives as Pin1 inhibitors by high-throughput screening.2016
    • Author(s)
      Subedi A, Shimizu T, Ryo A, Sanada E, Watanabe N, Osada H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 474 Pages: 528-533

    • DOI

      10.1016/j.bbrc.2016.04.124

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Journal Article] Biosynthetic approaches to creating bioactive fungal metabolites: Pathway engineering and activation of secondary metabolism2016
    • Author(s)
      Motoyama T, Osada H
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 26 Pages: 5843-5850

    • DOI

      10.1016/j.bmcl.2016.11.013

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-26450109

  • [Journal Article] dentification of a novel compound that inhibits osteoclastogenesis by suppressing nucleoside transporters.2016
    • Author(s)
      S. Katsuyama, K. Sugino, Y. Sasazawa, Y. Nakano, H. Aono, K. Morishita, M. Kawatani, K. Umezawa, H. Osada and S. Simizu
    • Journal Title

      FEBS Lett

      Volume: 590 Pages: 1152-1162

    • DOI

      10.1002/1873-3468.12146

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26350975, KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-26750373, KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-16J40133, KAKENHI-PROJECT-16K01941

  • [Journal Article] Chemical and biological studies of reveromycin A.2016
    • Author(s)
      Osada H
    • Journal Title

      J Antibiot

      Volume: 69 Pages: 723-730

    • DOI

      10.1038/ja.2016.57

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Journal Article] Integrated profiling methods for identifying the targets of bioactive compounds : MorphoBase and ChemProteoBase.2016
    • Author(s)
      Muroi M, Futamura Y, Osada H.
    • Journal Title

      Nat Prod Rep

      Volume: 33 Pages: 621-625

    • DOI

      10.1039/c5np00106d

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-16H06276

  • [Journal Article] Reveromycin A administration prevents alveolar bone loss in osteoprotegerin knockout mice with periodontal disease.2015
    • Author(s)
      Mizuno M, Miyazawa K, Tabuchi M, Tanaka M, Yoshizako M, Minamoto C, Torii Y, Tamaoka Y, Kawatani M, Osada H, Maeda H, Goto S
    • Journal Title

      Scientific Reports

      Volume: 5 Pages: 16510-16510

    • DOI

      10.1038/srep16510

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-25463207

  • [Journal Article] Percutaneous Carbon Dioxide Treatment using a Gas Mist Generator Enhances the Collateral Blood Flow in the Ischemic Hindlimb2015
    • Author(s)
      Izumi, Y
    • Journal Title

      J Atheroscler Thromb

      Volume: 22 Issue: 1 Pages: 474-480

    • DOI

      10.5551/jat.23770

    • NAID

      130004677973

    • ISSN
      1340-3478, 1880-3873
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23591056, KAKENHI-PROJECT-24390064, KAKENHI-PROJECT-24591066, KAKENHI-PROJECT-24591101, KAKENHI-PROJECT-26340042, KAKENHI-PROJECT-26460344, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-15K15132

  • [Journal Article] Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme2015
    • Author(s)
      Choong-Soo Yun, Takayuki Motoyama & Hiroyuki Osada
    • Journal Title

      Nat Commun

      Volume: 6 Pages: 8758-8758

    • DOI

      10.1038/ncomms9758

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26450109, KAKENHI-PROJECT-15H02445

  • [Journal Article] Haenamindole, an unusual diketopiperazine derivative from a marine-derived Penicillium sp. KCB12F0052015
    • Author(s)
      Kim JW, Ko SK, Son S, Shin KS, Ryoo IJ, Hong YS, Oh H, Hwang BY, Hirota H, Takahashi S, Kim BY, Osada H, Jang JH, Ahn JS
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 25 Pages: 5398-5401

    • DOI

      10.1016/j.bmcl.2015.09.026

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Journal Article] RK-270A-C, New Oxindole Derivatives Isolated from a Microbial Metabolites Fraction Library of Streptomyces sp. RK85-270.2015
    • Author(s)
      Jang JP, Nogawa T, Uramoto M, Okano A, Futamura Y, Shimizu T, Takahashi S, Jang JH, Ahn JS, Osada H.
    • Journal Title

      J Antibiot

      Volume: 68 Pages: 293-295

    • DOI

      10.1038/ja.2014.141

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-24380052, KAKENHI-PROJECT-24619011, KAKENHI-PUBLICLY-25108726, KAKENHI-PROJECT-26450148, KAKENHI-PROJECT-15H02445

  • [Journal Article] Neuritogenic activity of tetradecyl 2, 3-dihydroxybenzoate is mediated through IGF-1 receptor/PI3K/MAPK signaling pathways.2015
    • Author(s)
      Tang R, Gao L, Kawatani M, Chen J, Cao X, Osada H, Xiang L, Qi J
    • Journal Title

      Mol. Pharmacol.

      Volume: 88 Pages: 326-334

    • DOI

      10.1124/mol.115.097758

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-25350981

  • [Journal Article] Identification of matrix metalloproteinase inhibitors by chemical arrays2015
    • Author(s)
      Kawatani M, Fukushima Y, Kondoh Y, Honda K, Sekine T, Yamaguchi Y, Taniguchi N, Osada H
    • Journal Title

      Bioscience Biotechnology and Biochemistry

      Volume: 79 Pages: 1597-1602

    • DOI

      10.1080/09168451.2015.1045829

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26350976, KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-15H04700

  • [Journal Article] Identification of Middle Chain Fatty Acyl-CoA Ligase Responsible for the Biosynthesis of 2-Alkylmalonyl-CoAs for Polyketide Extender Unit2015
    • Author(s)
      Miyazawa T., Takahashi S., Kawata A., Panthee S., Hayashi T., Shimizu T., Nogawa T., Osada H.
    • Journal Title

      J. Biol. Chem.

      Volume: 290 Pages: 26994-27011

    • DOI

      10.1074/jbc.m115.677195

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26450148, KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-24380052

  • [Journal Article] Construction and application of a photo-cross-linked chemical array2015
    • Author(s)
      Kondoh Y, Honda K, Osada H
    • Journal Title

      Methods Mol Biol

      Volume: 1263 Pages: 29-41

    • DOI

      10.1007/978-1-4939-2269-7_3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26350976, KAKENHI-PROJECT-15H02445

  • [Journal Article] A new enzyme involved in the control of the stereochemistry in the decalin formation during equisetin biosynthesis2015
    • Author(s)
      Kato N, Nogawa T, Hirota H, Jang JH, Takahashi S, Ahn JS, Osada H.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 460 Pages: 210-215

    • DOI

      10.1016/j.bbrc.2015.03.011

    • NAID

      130007491120

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-24380052, KAKENHI-PUBLICLY-25108725, KAKENHI-PROJECT-26450148, KAKENHI-PROJECT-15H02445

  • [Journal Article] Inhibition of malaria parasite growth by quinomycin A and its derivatives through DNA-intercalating2015
    • Author(s)
      Hayase H, Watanabe N, Lim CL, Nogawa T, Komatsuya K, Kita K, Osada H.
    • Journal Title

      Biosci., Biotech., Biochem.

      Volume: 79 Pages: 633-5

    • DOI

      10.1080/09168451.2014.987205

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-26450148, KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-15J04920, KAKENHI-PROJECT-24510320

  • [Journal Article] Novel Abscisic Acid Antagonists Identified with Chemical Array Screening.2015
    • Author(s)
      Ito T, Kondoh Y, Yoshida K, Umezawa T, Shimizu T, Shinozaki K, Osada H
    • Journal Title

      Chembiochem

      Volume: 16 Pages: 2471-2478

    • DOI

      10.1002/cbic.201500429

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26350976, KAKENHI-PROJECT-15K13998, KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-15H04383, KAKENHI-PROJECT-24370023

  • [Journal Article] Hsc70 Contributes to Cancer Cell Survival by Preventing Rab1A Degradation under Stress Conditions.2014
    • Author(s)
      Tanaka M, Mun S, Harada A, Ohkawa Y, Inagaki A, Sano S, Takahashi K, Izumi Y, Osada-Oka M, Wanibuchi H, Yamagata M, Yukimura T, Miura K, Shiota M, Iwao H.
    • Journal Title

      PLoS One.

      Volume: 9

    • DOI

      10.1371/journal.pone.0096785

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-13J04024, KAKENHI-PROJECT-24390064, KAKENHI-PROJECT-24501015, KAKENHI-PROJECT-26340042, KAKENHI-PROJECT-26890021, KAKENHI-PROJECT-221S0001

  • [Journal Article] A small molecule that induces reactive oxygen species via cellular glutathione depletion.2014
    • Author(s)
      Kawamura T, Kondoh Y, Muroi M, Kawatani M, Osada H.
    • Journal Title

      Biochemical Journal

      Volume: 463 Pages: 53-63

    • DOI

      10.1042/bj20140669

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-25750397, KAKENHI-PROJECT-26350976

  • [Journal Article] A small compound targeting TACC3 revealed its spatiotemporally different contributions to the spindle assembly in cancer cells2014
    • Author(s)
      Yao R, Kondoh Y, Natsume Y, Yamanaka H, Inoue M, Toki H, Takagi R, Shimizu T, Yamori T, Osada H, Noda T
    • Journal Title

      Oncogene

      Volume: in press Issue: 33 Pages: 1-11

    • DOI

      10.1038/onc.2013.382

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23510287, KAKENHI-PROJECT-25640094, KAKENHI-PROJECT-26350976, KAKENHI-PROJECT-221S0001

  • [Journal Article] Establishment of neutralizing rat monoclonal antibodies for fibroblast growth factor-2.2014
    • Author(s)
      Tanaka M, Yamaguchi M, Shiota M, Kawamoto Y, Takahashi K, Inagaki A, Osada-Oka M, Harada A, Wanibuchi H, Izumi Y, Miura K, Iwao H, Ohkawa Y.
    • Journal Title

      Monoclon Antib Immunodiagn Immunother.

      Volume: 33 Pages: 261-269

    • DOI

      10.1089/mab.2013.0085

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-13J04024, KAKENHI-PROJECT-24390064, KAKENHI-PROJECT-26340042, KAKENHI-PROJECT-26890021, KAKENHI-PROJECT-221S0001

  • [Journal Article] Structure-function analyses of cytochrome P450revI involved in reveromycin A biosynthesis and evaluation of the biological activity of its substrate, reveromycin T.2014
    • Author(s)
      Shunji Takahashi, Shingo Nagano, Toshihiko Nogawa, Naoki Kanoh, Masakazu Uramoto, Makoto Kawatani, Yoshitsugu Shiro, Hiroyuki Osada
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 289 Pages: 32446-32458

    • DOI

      10.1074/jbc.m114.598391

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23102013, KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-24380052, KAKENHI-PUBLICLY-25108726, KAKENHI-PROJECT-25291015, KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-26450148

  • [Journal Article] Xanthohumol suppresses oestrogen-signalling in breast cancer through the specific inhibition of BIG3-PHB2 interactions.2014
    • Author(s)
      Yoshimaru T, Komatsu M, Tashiro E, Imoto M, Osada H, Miyoshi M, Honda J, Sasa M, and Katagiri T
    • Journal Title

      Sci Rep

      Volume: 4 Pages: 7335-7335

    • DOI

      10.1038/srep07355

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23102006, KAKENHI-PUBLICLY-25134712, KAKENHI-PROJECT-25293079, KAKENHI-PROJECT-26350974, KAKENHI-PROJECT-26461948, KAKENHI-PROJECT-26860212, KAKENHI-PROJECT-221S0001

  • [Journal Article] RK-1355A and B, Novel Quinomycin Derivatives Isolated from a Microbial Metabolites Fraction Library Based on NPPlot Screening.2014
    • Author(s)
      Lim CL, Nogawa T, Uramoto M, Okano A, Hongo Y, Nakamura T, Koshino H, Takahashi S, Ibrahim D, Osada H.
    • Journal Title

      The Journal of Antibiotics

      Volume: 67 Pages: 323-329

    • DOI

      10.1038/ja.2013.144

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-24380052, KAKENHI-PROJECT-24619011, KAKENHI-PROJECT-24658088, KAKENHI-PUBLICLY-25108726

  • [Journal Article] Identification of small molecule inhibitors of p27Kip1 ubiquitination by high-throughput screening.2013
    • Author(s)
      Kasahara, K., Goto, H., Izawa, I., Kiyono, T., Watanabe, N., Elowe, S., Nigg, EA., and Inagaki, M.
    • Journal Title

      Cancer Sci.

      Volume: 4 Pages: 1461-1467

    • DOI

      10.1111/cas.12246

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24510320, KAKENHI-PROJECT-221S0001

  • [Journal Article] Isolation of new polyketide metabolites, linearolides A and B, from Streptomyces sp. RK95-74.2013
    • Author(s)
      Ueki M. et al.
    • Journal Title

      J Antibiot (Tokyo)

      Volume: - Pages: 333-337

    • DOI

      10.1038/ja.2013.19

    • NAID

      10031183840

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22681034, KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-25350981

  • [Journal Article] Molecular target identification of a novel fungal metabolite, pyrrolizilactone, by phenotypic profiling systems2013
    • Author(s)
      Futamura Y, Kawatani M, Muroi M, Aono H, Nogawa T, Osada H,
    • Journal Title

      Chembiochem

      Volume: 14 Pages: 2456-2463

    • DOI

      10.1002/cbic.201300499

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-24102536, KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-25750396

  • [Journal Article] Spectomycin B1 as a novel SUMOylation inhibitor that directly binds to SUMO E22013
    • Author(s)
      Hirohama M, Kumar A, Fukuda I, Matsuoka S, Igarashi Y, Saitoh H, Takagi M, Shin-ya K, Honda K, Kondoh Y, Saito T, Nakao Y, Osada H, Zhang KY, Yoshida M, Ito A
    • Journal Title

      ACS Chem Biol.

      Volume: 8 Pages: 2635-2642

    • DOI

      10.1021/cb400630z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23510287, KAKENHI-PROJECT-23510288, KAKENHI-PROJECT-23616004, KAKENHI-PROJECT-221S0001

  • [Journal Article] Pyrrolizilactone, a new pyrrolizidinone metabolite produced by a fungus2013
    • Author(s)
      Nogawa T, Kawatani M, Uramoto M, Okano A, Aono H, Futamura Y, Koshino H, Takahashi S, Osada H.
    • Journal Title

      J. Antibiot.

      Volume: 66 Pages: 621-623

    • DOI

      10.1038/ja.2013.55

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-24380052, KAKENHI-PROJECT-24658088, KAKENHI-PUBLICLY-25108726, KAKENHI-PROJECT-25350981

  • [Journal Article] A Point Mutation in <i>ftmD</i> Blocks the Fumitremorgin Biosynthetic Pathway in <i>Aspergillus fumigatus</i> Strain Af2932013
    • Author(s)
      Kato N, Suzuki H, Okumura H, Takahashi S, Osada H
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 77 Issue: 5 Pages: 1061-1067

    • DOI

      10.1271/bbb.130026

    • NAID

      10031177597

    • ISSN
      0916-8451, 1347-6947
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-24380052, KAKENHI-PROJECT-24658088, KAKENHI-PUBLICLY-25108725, KAKENHI-PUBLICLY-25108726

  • [Journal Article] Systematic isolation of microbial metabolites for natural products depository (NPDepo).2012
    • Author(s)
      Osada H, Nogawa T.
    • Journal Title

      Pure Appl Chem

      Volume: 84(6) Pages: 1407-20

    • DOI

      10.1351/pac-con-11-08-11

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-221S0001

  • [Journal Article] Speculation of small molecule targets by proteomic profiling using two-dimensional fluorescence differential gel electrophoresis2010
    • Author(s)
      Muroi M, Kazami S, Noda K, Kondo H, Takayama H, Kawatani M, Usui T, Osada H.
    • Journal Title

      Chem Biol (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17012025

  • [Journal Article] Functional characterization of TtnD and TtnF unveiling new insights into tautomycetin biosynthesis.2010
    • Author(s)
      Osada, H. (11名中10番目)
    • Journal Title

      J. Am. Chem. Soc. 132

      Pages: 6663-6671

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Cleavable linker for photo-cross-linked small-molecule affinity matrix.2010
    • Author(s)
      Osada, H. (8名中7番目)
    • Journal Title

      Bioconjugate Chem. 21

      Pages: 182-186

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Cleavable linker for photo-cross-linked small-molecule affinity matrix.2010
    • Author(s)
      Kanoh, N. (8名中1番目), Simizu, S. (8名中6番目), Osada, H. (8名中7番目)
    • Journal Title

      Bioconjugate Chem. 21

      Pages: 182-186

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] In vitro reconstruction of tetronate RK-682 biosynthesis.2010
    • Author(s)
      Osada, H. (7名中6番目)
    • Journal Title

      Nature Chem. Biol. 6

      Pages: 99-101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Genome-wide maps of mononucleosomes and dinucleosomes containing hyper-acetylated histones of Aspergillus fumigatus.2010
    • Author(s)
      Osada, H. (6名中6番目)
    • Journal Title

      PLoS One 5

      Pages: 9916-9916

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Biochemical characterization of a novel indole prenyltransferase from Streptomyces sp. SN-593.2010
    • Author(s)
      Takahashi, S. (8名中1番目), Osada, H. (8名中8番目)
    • Journal Title

      J. Bacteriol. 192

      Pages: 2839-2851

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] In vitro reconstruction of tetronate RK-682 biosynthesis.2010
    • Author(s)
      Osada, H. (7名中6番目)
    • Journal Title

      Nat. Chem. Biol. 6

      Pages: 99-101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor.2010
    • Author(s)
      Osada, H. (11名中9番目), Yoshida, M. (11名中11番目)
    • Journal Title

      Biochem. Biophys. Res. Commun. 394

      Pages: 569-573

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Discovery of novel antiviral agents directed against the influenza A virus nucleoprotein using photo-cross-linked chemical arrays.2010
    • Author(s)
      Osada, H. (9名中8番目)
    • Journal Title

      Biochem. Biophys. Res. Commun. 394

      Pages: 721-727

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Polo-like kinase 1 phosphorylates and regulates Bcl-xL during pironetin-induced apoptosis.2009
    • Author(s)
      Simizu, S. (7名中2番目), Muroi, M. (7名中3番目), Osada, H. (7名中7番目)
    • Journal Title

      Oncogene 28

      Pages: 107-116

    • NAID

      120006385868

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Structure-affinity relationship study of bleomycins and Shble protein by use of a chemical array.2009
    • Author(s)
      Okumura, H. (8名中2番目), Osada, H. (8名中10番目)
    • Journal Title

      Chembiochem 10

      Pages: 845-852

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus.2009
    • Author(s)
      Kakeya, H. (10名中5番目), Usui, T. (10名中7番目), Takahashi, S. (10名中8番目), Osada, H. (10名中10番目)
    • Journal Title

      Chembiochem 23

      Pages: 920-928

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] ATM blocks tunicamycin-induced endoplasmic reticu-lum stress.2009
    • Author(s)
      Osada, H. (10名中7番目)
    • Journal Title

      FEBS Lett. 583

      Pages: 903-908

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] 農薬開発とケミカルバイオロジー2009
    • Author(s)
      長田裕之
    • Journal Title

      日本農薬学会誌 34

      Pages: 215-220

    • NAID

      110007340709

    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Osteoclast-targeting small molecules for the treatment of neoplastic bone metastases.2009
    • Author(s)
      Osada, H. (2名中2番目)
    • Journal Title

      Cancer Sci. 100

      Pages: 1999-2005

    • NAID

      10027196327

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity.2009
    • Author(s)
      Osada, H. (8名中7番目)
    • Journal Title

      Org. Lett. 11

      Pages: 1639-1642

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] 農薬開発とケミカルバイオロジー2009
    • Author(s)
      長田裕之
    • Journal Title

      日本農薬学会誌 34

      Pages: 215-220

    • NAID

      110007340709

    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Deficiency in chromosome congression by the inhibition of PLK1 polo box domain-dependent recognition.2009
    • Author(s)
      Osada, H. (7名中7番目)
    • Journal Title

      J. Biol. Chem. 284

      Pages: 2344-2353

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] RECK negatively regulates matrix metalloproteinase-9 transcription.2009
    • Author(s)
      Simizu, S. (3名中2番目), Osada, H. (3名中3番目)
    • Journal Title

      Cancer Res. 69

      Pages: 1502-1508

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Kerriamycin B inhibits protein SUMOylation.2009
    • Author(s)
      Osada, H. (7名中6番目), Yoshida, M. (7名中7番目)
    • Journal Title

      J. Antibiot. 62

      Pages: 221-224

    • NAID

      10030635072

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] A cell-based screening to detect inhibitors of BRAF signaling pathway.2009
    • Author(s)
      Usui, T. (8名中7番目), Osada, H. (8名中8番目)
    • Journal Title

      J. Antibiot. 62

      Pages: 105-107

    • NAID

      10030634719

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Genome-wide maps of mono-and di-nucleosomes of Aspergillus fumigatus.2009
    • Author(s)
      Osada, H. (5名中5番目)
    • Journal Title

      Bioinformatics 25

      Pages: 2295-2297

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Structure-affinity relationship study of bleomycins and Shble protein by use of a chemical array.2009
    • Author(s)
      Simizu, S. (8名中3番目), Kanoh, N. (8名中5番目), Osada, H. (8名中8番目)
    • Journal Title

      Chembiochem 10

      Pages: 845-852

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Characterization of the tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes provides new insight into dialkylmaleic anhydride biosynthesis.2009
    • Author(s)
      Osada, H. (6名中5番目)
    • Journal Title

      J. Nat. Prod. 72

      Pages: 450-459

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] On-chip fragment-based approach for discovery of high-affinity bivalent inhibitors.2009
    • Author(s)
      Simizu, S. (4名中2番目), Osada, H. (4名中4番目)
    • Journal Title

      Chembiochem 10

      Pages: 838-843

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Inhibition of protein tyrosine phosphatase 1B by lupeol and lupenone isolated from Sorbus commixta.2009
    • Author(s)
      Osada, H. (4名中3番目)
    • Journal Title

      J. Enzyme Inhib. Med. Chem. 24

      Pages: 1056-1059

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Osteoclast-targeting small molecules for the treatment of neoplastic bone metastases.2009
    • Author(s)
      Osada, H. (2名中2番目)
    • Journal Title

      Cancer Sci. 100

      Pages: 1999-2005

    • NAID

      10027196327

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Functional analyses of cytochrome P450 genes responsible for the early steps of brassicicene C biosynthesis.2009
    • Author(s)
      Takahashi, S. (9名中3番目), Osada, H. (9名中4番目)
    • Journal Title

      Bioorg. Med. Chem. Lett. 19

      Pages: 5640-5643

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Involvement of cyclophilin D in mitochondrial permeability transition induction in intact cells.2009
    • Author(s)
      Osada, H. (5名中4番目)
    • Journal Title

      Arch. Biochem. Biophys. 481

      Pages: 59-64

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Polo-like kinase 1 phosphorylates and regulates Bcl-x(L) during pironetin-induced apoptosis.2009
    • Author(s)
      Osada, H. (7名中7番目)
    • Journal Title

      Oncogene 28

      Pages: 107-116

    • NAID

      120006385868

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Exploring the chemical space of microbial natural products2009
    • Author(s)
      長田裕之, et al.
    • Journal Title

      Curr.Opn.Chem.Biol. 13

      Pages: 133-134

    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Exploring the chemical space of microbial natural products.2009
    • Author(s)
      Osada, H. (2名中1番目)
    • Journal Title

      Curr. Opin. Chem. Biol. 13

      Pages: 133-134

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Deficiency in chromosome congression by the inhibition of Plk1 polo box domain-dependent recognition.2009
    • Author(s)
      Osada, H. (7名中7番目)
    • Journal Title

      J. Biol. Chem. 284

      Pages: 2344-2353

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells.2009
    • Author(s)
      Simizu, S. (8名中1番目), Osada, H. (8名中8番目)
    • Journal Title

      Biochem. Biophys. Res. Commun. 383

      Pages: 406-410

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] A p38 mitogen-activated protein kinase inhibitor screening method using growth recovery of Escherichia coli as an index.2009
    • Author(s)
      Saito, A. (4名中2番目), Osada, H. (4名中4番目)
    • Journal Title

      Anal. Biochem. 388

      Pages: 128-133

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Exploring the chemical space of microbial natural products2009
    • Author(s)
      長田裕之, et al.
    • Journal Title

      Curr.Opn.Chem.Biol. 13

      Pages: 133-134

    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus.2009
    • Author(s)
      Osada, H. (10名中10番目)
    • Journal Title

      Chembiochem 10

      Pages: 920-928

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Specific regulation of cytokine dependent p38 MAP kinase activation by p62/SQSTM1.2008
    • Author(s)
      Sudo, T. (4名中3番目), Osada, H. (4名中4番目)
    • Journal Title

      J. Biochem. 143

      Pages: 765-772

    • NAID

      10024910311

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone.2008
    • Author(s)
      Osada, H. (7名中6番目)
    • Journal Title

      Proc. Natl. Acad. Sci. USA. 105

      Pages: 15541-15546

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone.2008
    • Author(s)
      Osada, H. (7名中6番目)
    • Journal Title

      Proc. Natl. Acad. Sci. USA 105

      Pages: 15541-15546

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis.2008
    • Author(s)
      Osada, H. (5名中4番目)
    • Journal Title

      J. Biol. Chem. 283

      Pages: 28607-28617

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Epoxyquinol B, a naturally occurring pentaketide dimer, inhibits NF-kappaB signaling by crosslinking TAK1.2008
    • Author(s)
      Osada, H. (7名中7番目)
    • Journal Title

      Biosci. Biotechnol. Biochem. 72

      Pages: 1894-1900

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] 癌の分子生物と分子標的2008
    • Author(s)
      長田裕之
    • Journal Title

      Frontiers in Gastroentelogy 13

      Pages: 66-73

    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Distribution of photo-cross-linked products from 3-aryl-3-trifluoro-methyldiazirines and alcohols.2008
    • Author(s)
      Osada, H. (6名中6番目)
    • Journal Title

      Tetrahedron 64

      Pages: 5692-5698

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I.2008
    • Author(s)
      Kanoh, N. (7名中4番目), Muroi, M. (7名中5番目), Osada, H. (11名中11番目)
    • Journal Title

      Proc. Natl. Acad. Sci. USA. 105

      Pages: 11691-11696

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Requirement of the conserved, hydrophobic C-terminus region for the activation of heparanase.2008
    • Author(s)
      Simizu, S. (5名中2番目), Osada, H. (5名中5番目)
    • Journal Title

      Exp. Cell Res 314

      Pages: 2834-2845

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Improvement of photoaffinity SPR imaging platform and determination of binding site of p62/SQSTM1 to p38 MAP kinase.2008
    • Author(s)
      Saito, A. (6名中1番目), Osada, H. (6名中6番目)
    • Journal Title

      Chemistry Asian J. 3

      Pages: 1607-1612

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] A fungal metabolite, epoxyquinol B inhibits the NF-kappaB signal through the crosslinking of TAK1.2008
    • Author(s)
      Usui, T. (7名中2番目), Hayashi, Y. (7名中5番目), Kakeya, H. (7名中6番目), Osada, H. (7名中7番目)
    • Journal Title

      Biosci. Biotechnol. Biochem. 72

      Pages: 1894-1900

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] 癌の分子生物と分子標的2008
    • Author(s)
      長田 裕之
    • Journal Title

      Frontiers in Gastroentelogy 13

      Pages: 66-73

    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Robust and systematic drug screening method using chemical arrays and the protein library: Identification of novel inhibitors of carbonic anhydrase II.2008
    • Author(s)
      Osada, H. (5名中5番目)
    • Journal Title

      Biosci. Biotechnol. Biochem. 72

      Pages: 2739-2749

    • NAID

      10027533381

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Epoxyquinol B shows antiangiogenic and antitumor effects by inhibiting VEGFR2, EGFR, FGFR, and PDGFR.2008
    • Author(s)
      Kamiyama, H. Kakeya, H. Usui, T. Nishikawa, K. Shoji, M. Hayashi, Y. and Osada, H.
    • Journal Title

      Oncol Res (in press)

    • NAID

      120006385617

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17012025

  • [Journal Article] Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation.2008
    • Author(s)
      Osada, H. (8名中8番目)
    • Journal Title

      Cancer Sci. 99

      Pages: 1853-1858

    • NAID

      10024011306

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I.2008
    • Author(s)
      Okumura, H. (11名中2番目), Osada, H. (11名中11番目)
    • Journal Title

      Proc. Natl. Acad. Sci. USA 105

      Pages: 11691-11696

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation.2008
    • Author(s)
      Osada, H. (8名中8番目)
    • Journal Title

      J. Antibiot. 61

      Pages: 94-97

    • NAID

      80019478123

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Distribution of photo-cross-linked products from 3-aryl-3-trifluoromethyldiazirines and alcohols.2008
    • Author(s)
      Kanoh, N. (6名中1番目), Osada, H. (6名中6番目)
    • Journal Title

      Tetrahedron 64

      Pages: 5692-5698

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Synthesis and biological activities of reveromycin A and spirofungin a derivatives.2008
    • Author(s)
      Shimizu, T. (10名中1番目), Usui, T. (10名中2番目), Osada, H. (10名中9番目)
    • Journal Title

      Bioorg. Med. Chem. Lett. 18

      Pages: 3756-3760

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation.2008
    • Author(s)
      Usui, T. (8名中2番目), Hayashi, Y. (8名中6番目), Kakeya, H. (8名中7番目), Osada, H. (8名中8番目)
    • Journal Title

      J. Antibiot. 61

      Pages: 94-97

    • NAID

      80019478123

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Epoxyquinol B shows antiangiogenic effects by inhibiting not only VEGFR2 but also EGFR, FGFR, and PDGFR.2008
    • Author(s)
      Kakeya, H. (7名中2番目), Usui, T. (7名中3番目), Hayashi, Y. (7名中6番目), Osada, H. (7名中7番目)
    • Journal Title

      Oncol. Res. 17

      Pages: 11-21

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] RECK negatively regulates matrix metalloproteinase-9 transcription.2008
    • Author(s)
      Takagi, S. Simizu, S. Osada, H.
    • Journal Title

      Cancer Res 69

      Pages: 1502-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17012025

  • [Journal Article] Synthesis and biological activities of reveromycin A and spirofungin A derivatives.2008
    • Author(s)
      Kanoh, N. (10名中7番目), Osada, H. (10名中9番目)
    • Journal Title

      Bioorg. Med. Chem. Lett. 18

      Pages: 3756-3760

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Synthesis and anti-angiogenic activity of cortistatin analogs.2008
    • Author(s)
      Usui, T. (7名中3番目), Osada, H. (7名中5番目)
    • Journal Title

      Biosci. Biotechnol. Biochem. 72

      Pages: 2992-2997

    • NAID

      10027534251

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein.2008
    • Author(s)
      Kakeya, H. (15名中13番目), Osada, H. (15名中14番目)
    • Journal Title

      Bioorg. Med. Chem. 16

      Pages: 4626-4651

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation.2008
    • Author(s)
      Kakeya, H. (8名中2番目), Kojima, S. (8名中4番目), Osada, H. (8名中8番目)
    • Journal Title

      Cancer Sci. 99

      Pages: 1853-1858

    • NAID

      10024011306

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Specific regulation of cytokine dependent p38 MAP kinase activation by p62/SQSTM1.2008
    • Author(s)
      Saito, A. (4名中3番目), Osada, H. (4名中4番目)
    • Journal Title

      J. Biochem. 143

      Pages: 765-772

    • NAID

      10024910311

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages.2008
    • Author(s)
      Osada, H. (12名中10番目)
    • Journal Title

      Cancer Sci. 99

      Pages: 1595-1602

    • NAID

      10024009829

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] The identification of anosteoclastogenesis inhibitor through the inhibition of glyoxalase I.2008
    • Author(s)
      Kawatani M, Okumura H, Honda K, Kanoh N, Muroi M, Dohmae N, Takami M, Kitagawa M, Futamura Y, Imoto M, Osada H.
    • Journal Title

      Proc Natl Acad Sci, USA 105

      Pages: 11691-11696

    • Data Source
      KAKENHI-PROJECT-17012025

  • [Journal Article] Epoxyquinol B shows antiangiogenic effects in vitro and in vivo by inhibiting not only VEGFR2 but also EGFR, FGFR, and PDGFR.2008
    • Author(s)
      Osada, H. (7名中7番目)
    • Journal Title

      Oncol. Res. 17

      Pages: 11-21

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] The asymmetric total synthesis of (+)-cytotrienin A, an ansamycin-type anticancer drug.2008
    • Author(s)
      Hayashi, Y. (10名中1番目), Kakeya, H. (10名中9番目), Osada, H. (10名中10番目)
    • Journal Title

      Angew. Chem. Int. Ed. 47

      Pages: 6657-6660

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Antiproliferating activity of the mitotic inhibitor pironetin against vindesine-and paclitaxel-resistant human small cell lung cancer H69 cells.2007
    • Author(s)
      Usui, T. (6名中4番目), Osada, H. (6名中5番目)
    • Journal Title

      Anticancer Res. 27

      Pages: 729-736

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Glaziovianin A, a new isoflavone, from the leaves of Ateleia glazioviana and its cytotoxic activity against human cancer cells.2007
    • Author(s)
      Usui, T. (7名中3番目), Osada, H. (7名中5番目)
    • Journal Title

      Bioorg. Med. Chem. Lett. 17

      Pages: 3091-3094

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Synthesis of (+)-vinblastine and its analogues.2007
    • Author(s)
      Osada, H. (6名中4番目)
    • Journal Title

      Org. Lett. 9

      Pages: 4737-4740

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Involvement of disulfide bond formation in the activation of heparanase.2007
    • Author(s)
      Simizu, S. (7名中1番目), Muroi, M. (7名中3番目), Osada, H. (7名中7番目)
    • Journal Title

      Cancer Res. 67

      Pages: 7841-7849

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Involvement of disulfide bond formation in the activation of heparanase.2007
    • Author(s)
      Osada, H. (7名中7番目)
    • Journal Title

      Cancer Res. 67

      Pages: 7841-7849

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Involvement of disulfide bond formation in the activation of heparanase.2007
    • Author(s)
      Simizu, S. Suzuki, T. Muroi, M. Lai, N. S. Takagi, S. Dohmae, N. and Osada, H.
    • Journal Title

      Cancer Res. 67

      Pages: 7841-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17012025

  • [Journal Article] Iejimalides, the antitumor 24-membered macrolides, are novel V-ATPases inhibitors., Biosci.2006
    • Author(s)
      Muroi, M. (7名中2番目), Osada, H. (7名中7番目)
    • Journal Title

      Biotechnol. Biochem. 70

      Pages: 1364-1370

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Enzymatic generation of the antimetabolite gamma, gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete.2006
    • Author(s)
      Ueki, M. (9名中1番目), Osada, H. (9名中8番目)
    • Journal Title

      Chem. Biol. 13

      Pages: 1183-1191

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Suppression of apoptosis by cyclophilin D via stabilization of hexokinase II mitochondrial binding in cancer cells.2006
    • Author(s)
      Osada, H. (3名中3番目)
    • Journal Title

      J. Biol. Chem. 281

      Pages: 14314-14320

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts.2006
    • Author(s)
      Kanoh, N. (12名中6番目), Osada, H. (12名中12番目)
    • Journal Title

      Proc. Natl. Acad. Sci., USA. 103

      Pages: 4729-4734

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] RK-95113, a new angiogenesis inhibitor produced by Aspergillus fumigatus.2006
    • Author(s)
      Osada, H. (5名中5番目)
    • Journal Title

      J. Antibiot. 59

      Pages: 724-728

    • NAID

      10019271192

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Suppression of apoptosis by cyclophilin D via stabilization of hexokinase II mitochondrial binding in cancer cells.2006
    • Author(s)
      Osada, H. (3名中3番目)
    • Journal Title

      J. Biol. Chem. 281

      Pages: 14314-14320

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Brasilicardin A, a natural immunosuppressant, targets amino acid transport system L.2006
    • Author(s)
      Usui, T. (7名中1番目), Osada, H. (7名中7番目)
    • Journal Title

      Chem. Biol. 13

      Pages: 1153-1160

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Suppression of apoptosis by cyclophilin D via stabilization of hexokinase II mitochondrial binding in cancer cells.2006
    • Author(s)
      Machida, K., Ohta, Y., Osada, H.
    • Journal Title

      J Biol Chem 281

      Pages: 14314-20

    • Data Source
      KAKENHI-PROJECT-17012025

  • [Journal Article] Brasilicardin A, a natural immunosuppressant, targets amino acid transport system L.2006
    • Author(s)
      Osada, H. (7名中7番目)
    • Journal Title

      Chem. Biol. 13

      Pages: 1153-1160

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] SPR imaging measurement of photo-cross-linked small molecule microarrays on gold.2006
    • Author(s)
      Kanoh, N. (7名中1番目), Osada, H. (7名中7番目)
    • Journal Title

      Anal. Chem. 78

      Pages: 2226-2230

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Iejimalides shows anti-osteoclast activity via V-ATPase inhibition.2006
    • Author(s)
      Usui, T. (7名中5番目), Osada, H. (7名中7番目)
    • Journal Title

      Biosci. Biotechnol. Biochem. 70

      Pages: 1364-1370

    • NAID

      10018529971

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways.2005
    • Author(s)
      Osada, H. (7名中7番目)
    • Journal Title

      Proc. Natl. Acad. Sci., USA. 102

      Pages: 11663-11668

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Epoxytwinol A, a novel unique angiogenesis inhibitor with C2 symmetry, produced by a fungus.2005
    • Author(s)
      Osada, H. (4名中4番目)
    • Journal Title

      Chem. Commun. 20

      Pages: 2575-2577

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways.2005
    • Author(s)
      Watanabe N, Arai H, Iwasaki Ji, Shiina M, Ogata K, Hunter T, Osada H.
    • Journal Title

      Proc.Natl.Acad.Sci.U.S.A. 102(33)

      Pages: 11663-11668

    • Data Source
      KAKENHI-PROJECT-17012025

  • [Journal Article] Reveromycin A inhibits osteolytic bone metastasis of small-cell lung cancer cells, SBC-5, through an anti-osteoclastic activity.2005
    • Author(s)
      Osada, H. (7名中6番目)
    • Journal Title

      Clin. Cancer Res. 11

      Pages: 8822-8828

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] p38 mitogen-activated protein kinase plays a key role in regulating MAPKAPK2 expression.2005
    • Author(s)
      Sudo, T. (4名中1番目), Osada, H. (4名中4番目)
    • Journal Title

      Biochem. Biophys. Res. Commun. 337

      Pages: 415-421

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Epoxytwinol A, a novel unique angiogenesis inhibitor with C2 symmetry, produced by a fungus.2005
    • Author(s)
      Osada, H. (4名中4番目)
    • Journal Title

      Chem. Commun. 20

      Pages: 2575-2577

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Reveromycin A inhibits osteolytic bone metastasis of small-cell lung cancer cells, SBC-5, through an anti-osteoclastic activity.2005
    • Author(s)
      Osada, H. (7名中6番目)
    • Journal Title

      Clin. Cancer Res. 11

      Pages: 8822-8828

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Cyclindependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways.2005
    • Author(s)
      Osada, H. (7名中7番目)
    • Journal Title

      Proc. Natl. Acad. Sci. USA 102

      Pages: 11663-11668

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines.2005
    • Author(s)
      Simizu, S. (4名中1番目), Osada, H. (4名中4番目)
    • Journal Title

      Cancer Res. 65

      Pages: 7455-7461

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Phoslactomycin targets cysteine-269 of the protein phosphatase 2A catalytic subunit in cells.2005
    • Author(s)
      Simizu, S. (4名中2番目), Kanoh, N. (4名中3番目), Osada, H. (4名中4番目)
    • Journal Title

      FEBS Lett. 579

      Pages: 2463-2468

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Photo-crosslinked small molecule affinity matrix for facilitating forward and reverse chemical genetics.2005
    • Author(s)
      Kanoh, N. (5名中1番目), Simizu, S. (5名中3番目), Muroi, M. (5名中4番目), Osada, H. (5名中5番目)
    • Journal Title

      Angew. Chem. Int. Ed. 44

      Pages: 3559-3562

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079

  • [Journal Article] Development and application of bioprobes for mammalian cell cycle analyses2003
    • Author(s)
      H.Osada
    • Journal Title

      Curr.Med.Chem. 10

      Pages: 727-732

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15310156

  • [Journal Article] Development and application of bioprobes for mammalian cell cycle analyses.2003
    • Author(s)
      H.Osada
    • Journal Title

      Curr.Med.Chem. 10

      Pages: 727-732

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15310156

  • [Journal Article] Glyoxalase-I is a novel target against Bcr-Abl(+) leukemic cells acquiring stem-like characteristics in a hypoxic environment.
    • Author(s)
      Osada, H. (16名中6番目)
    • Journal Title

      Cell Death Differ. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Application of proteomic profiling based on 2-DIGE for classification of compounds according to the mechanism of action.
    • Author(s)
      Usui, T. (8名中7番目), Osada, H. (8名中8番目)
    • Journal Title

      Chem. Biol. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Journal Article] Modulation of E-cadherin expression by K-Ras; involvement of DNA methyltransferase-3b.
    • Author(s)
      Osada, H. (10名中7番目)
    • Journal Title

      Carcinogenesis (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0221

  • [Patent] 抗マラリア活性を示す新規生理活性物質及びその用途2021
    • Inventor(s)
      長田裕之、本山高幸、アブデルハキム イスラム アデル、二村友史
    • Industrial Property Rights Holder
      長田裕之、本山高幸、アブデルハキム イスラム アデル、二村友史
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-034047
    • Filing Date
      2021
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Patent] イネいもち病防除剤2019
    • Inventor(s)
      長田裕之、本山高幸、 清水猛、近藤恭光
    • Industrial Property Rights Holder
      長田裕之、本山高幸、 清水猛、近藤恭光
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-048574
    • Filing Date
      2019
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Patent] イネいもち病防除薬剤2019
    • Inventor(s)
      長田裕之, 本山高幸, 清水猛, 近藤恭光
    • Industrial Property Rights Holder
      理研
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Patent] 抗腫瘍・抗炎症作用を有する新規物質2007
    • Inventor(s)
      長田裕之、掛谷秀昭、今野宏、金澤進
    • Industrial Property Rights Holder
      独立行政法人理化学研究所、株式会社真菌類機能開発研究所
    • Acquisition Date
      2007-04-13
    • Data Source
      KAKENHI-PROJECT-17012025

  • [Patent] 抗生物質ヒドロキシホスラクトマイシン及びその製造方法並びに抗腫瘍剤及び抗真菌剤2006
    • Inventor(s)
      長田裕之, 植木雅志, 清水史郎, 照屋貴之, 小林雄一
    • Industrial Property Rights Holder
      独立行政法人理化学研究所, 国立大学法人東京工業大学
    • Industrial Property Number
      2006-221223
    • Filing Date
      2006-08-14
    • Data Source
      KAKENHI-PROJECT-17012025

  • [Presentation] 天然物創薬に適した表現系スクリーニング2021
    • Author(s)
      長田 裕之
    • Organizer
      日本農芸化学会東北支部 第155回大会
    • Invited
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] 天然物創薬に適した表現型スクリーニング2021
    • Author(s)
      長田 裕之
    • Organizer
      日本農芸化学会東北支部 第155回大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] A new peptaibol from the fungus Trichoderma sp. RK10-F026 by culture condition-dependent screening2021
    • Author(s)
      Mira Syahfriena Amir Rawa, Toshihiko Nogawa, Akiko Okano, Yushi Futamura, Takemichi Nakamura, Habibah A. Wahab, Hiroyuki Osada
    • Organizer
      日本農芸化学会2021年度大会
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] A new cytokinin-type compound and cytotoxic tryptamine derivatives from Streptomyces sp. 80H6472021
    • Author(s)
      Julius Lopez, Toshihiko Nogawa, Yushi Futamura, Harumi Aono, Kazuko Yoshida, Daisuke Hashizume, Hiroyuki Osada
    • Organizer
      日本農芸化学会2021年度大会
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] ドーパミン受容体アンタゴニストの受容体非依存的なフォーカス形成抑制能2021
    • Author(s)
      青山 愛、藤元次郎、平野弘之、渡辺信元、長田裕之、仙波憲太郎
    • Organizer
      第80回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H06276

  • [Presentation] カリン合成酵素 Phm7 および Fsa2 の in vitro アッセイ系の構築2021
    • Author(s)
      加藤 直樹 、藤山 敬介 、野川 俊彦 、長田 裕之 、永野 真吾 、高橋 俊二
    • Organizer
      日本農芸化学会2021年度大会
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Chemical induction of fungal secondary metabolism toward production of novel bioactive secondary metabolites2021
    • Author(s)
      Abdelhakim Amin Islam Adel、本山 高幸、二村 友史、長田 裕之
    • Organizer
      日本農芸化学会2021年度大会
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Target identification of NPD10084, a novel inhibitor of cancer metabolism.2020
    • Author(s)
      Osada, H.
    • Organizer
      Symposium on Convergent technologies for biomedical impact.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] 2DE-CETSAを用いたPKM2制御シグナルに作用する化合物NPD10084の同定2020
    • Author(s)
      室井 誠、永澤 生久子、小川 直子、川谷 誠、大石 智一、大庭 俊一、川田 学、長田 裕之
    • Organizer
      日本農芸化学会2020年度大会
    • Data Source
      KAKENHI-PROJECT-16H06276

  • [Presentation] 放線菌異種発現によるverticilactam新規類縁体の生産と単離・構造決定2020
    • Author(s)
      野川 俊彦、寺井 淳高、新家 一男、池田 治生、高橋 俊二、長田 裕之
    • Organizer
      日本農芸化学会2020年度大会
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] ハイグロマイシンBにより生産誘導される二次代謝産物の生合成遺伝子クラスター同定及び生理活性の解析2020
    • Author(s)
      加藤 翔、本山 高幸、二村 友史、浦本 昌和、長田 裕之
    • Organizer
      日本農芸化学会2020年度大会
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] イネいもち病菌の感染防除に関するケミカルバイオロジー研究2020
    • Author(s)
      本山 高幸、二村 友史、長田 裕之
    • Organizer
      日本農芸化学会2020年度大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] 放線菌由来抗生物質により生産誘導されるイネいもち病菌二次代謝産物の生理機能解析2020
    • Author(s)
      古山 祐貴、本山 高幸、野川 俊彦、鎌倉 高志、長田 裕之
    • Organizer
      日本農芸化学会2020年度大会
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] イネいもち病菌におけるpyriculol類縁体の未知生理機能の解析2020
    • Author(s)
      古山 祐貴 、本山 高幸 、鎌倉 高志、長田裕之
    • Organizer
      糸状菌分子生物学研究会若手の会 第八回ワークショップ
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] 新しいタイプの二次代謝酵素TAS1のホモログを活用した新規生理活性天然化合物の発掘2020
    • Author(s)
      本山 高幸、野川 俊彦、清水 猛、川谷 誠、二村 友史、尹 忠銖、長田 裕之
    • Organizer
      日本農芸化学会2020年度大会
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] タンパク質合成阻害剤hygromycin B処理による二次代謝の誘導と1233A生合成遺伝子クラスターの発見2020
    • Author(s)
      加藤 翔、本山 高幸、浦本 雅一、野川 俊彦、鎌倉 高志、長田 裕之
    • Organizer
      糸状菌分子生物学研究会若手の会 第八回ワークショップ
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Verticilactam生合成遺伝子クラスター異種発現による新規類縁体の単離と構造決定2020
    • Author(s)
      野川 俊彦、寺井 淳高、天貝 啓太、橋本 絢子、藤江 学、佐藤 矩行、池田 治生、新家 一男、長田 裕之、 高橋 俊二
    • Organizer
      第62回天然有機化合物討論会
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] 一次代謝関連遺伝子の導入によるリベロマイシン生産改善2020
    • Author(s)
      高木 海、白井 智量、岡村 英治、近藤 昭彦、長田 裕之、高橋 俊二
    • Organizer
      日本農芸化学会2020年度大会
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] 糸状菌RK17-F0007より単離したBR-050立体異性体の構造と活性評価2019
    • Author(s)
      野川 俊彦、川谷 誠、岡野 亜紀子、青野 晴美、清水 猛、長田 裕之
    • Organizer
      日本農芸化学会2019年度大会
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Target identification of small molecule compounds.2019
    • Author(s)
      Osada, H
    • Organizer
      浙江大学薬学院明徳弘薬セミナー
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] タンパク質合成阻害剤により生産誘導されるイネいもち病菌二次代謝産物の生理機能解析2019
    • Author(s)
      古山 祐貴、本山 高幸、鎌倉 高志、長田 裕之
    • Organizer
      19回糸状菌分子生物学研究会コンファレンス
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] 正常-がん細胞間作用によるフォーカス形成制御機構の化学生物学的解析2019
    • Author(s)
      青山 愛, 藤元 次郎, 平野 弘之, 渡辺 信元, 長田 裕之, 仙波 憲太郎
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H06276

  • [Presentation] イネいもち病菌におけるnectriapyrone類の生産誘導と生理機能解析2019
    • Author(s)
      本山 高幸、野川 俊彦、長田 裕之
    • Organizer
      19回糸状菌分子生物学研究会コンファレンス
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Selective activation of abscisic acid receptors by 3'-alkyl ABAs2019
    • Author(s)
      Kazuko Yoshida, Yasumitsu Kondoh, Iwahashi Fukumatsu, Takeshi Nakano, Kaori Honda, Eiki Nagano, Hiroyuki Osada
    • Organizer
      RIKEN-Max Planck Joint Research Center for System Chemical Biology 7th Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] 細胞形態変化を利用した抗真菌物質の探索2019
    • Author(s)
      二村 友史、Rachael Uson-Lopez、山本 甲斐、室井 誠、長田 裕之
    • Organizer
      日本農芸化学会2019年度大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] タンパク質合成阻害剤による糸状菌への二次代謝産物生産の誘導2019
    • Author(s)
      加藤翔、本山高幸、二村友史、浦本昌和、長田裕之
    • Organizer
      日本農芸化学会2019年度大会
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] 深層学習による形態識別を利用した抗真菌物質の探索2019
    • Author(s)
      二村 友史、ウソン－ ロペス レイチェル A.、山本 甲斐、室井 誠、長田 裕之
    • Organizer
      日本ケミカルバイオロジー学会 第14回年会
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Ring formation in biosynthesis of specialized microbial metabolites2019
    • Author(s)
      Hiroyuki Osada
    • Organizer
      2nd China-Japan Joint Symposium on Natural Product Biosynthesis
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Chemical synthesis or biosynthesis, that is the question2019
    • Author(s)
      Hiroyuki Osada, Toshihiko Nogawa, Naoki Kato
    • Organizer
      RIKEN-Max Planck Joint Research Center for System Chemical Biology 7th Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Tolypocladium albumにおいてNPD938によって生産誘導されるpyridoxatinとF14329の生合成と生産制御の解析2019
    • Author(s)
      石井友彬、本山高幸、野川 俊彦、鎌倉高志、長田裕之
    • Organizer
      日本農芸化学会2019年度大会
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] イネいもち病菌における二次代謝活性化2019
    • Author(s)
      本山高幸、野川俊彦、石井友彬、尹忠銖、長田 裕之
    • Organizer
      第61回天然有機化合物討論会
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] ケトシンターゼドメインによるかび毒テヌアゾン酸の環状骨格形成メカニズム2019
    • Author(s)
      尹 忠銖、西本 一希、 本山 高幸、日野 智也、永野 真吾、長田 裕之
    • Organizer
      19回糸状菌分子生物学研究会コンファレンス
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Biosynthesis of tenuazonic acid in Pyricularia oryzae.2019
    • Author(s)
      Osada, H
    • Organizer
      The Cold Spring Harbor Asia conference on Chemical Biology and Drug Discovery.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] イネいもち病菌における二次代謝活性化2019
    • Author(s)
      本山 高幸、野川 俊彦、尹 忠銖、長田 裕之
    • Organizer
      第10回発酵学フォーラム
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Screening of new antifungal compounds based on morphological change of fungi2019
    • Author(s)
      Hiroyuki Osada
    • Organizer
      The 2nd International Symposium on Natural Resources-based Drug Development
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] 微生物由来デカリン含有化合物のケミカルバイオロジー2019
    • Author(s)
      長田 裕之
    • Organizer
      理研シンポジウム: デカリン化合物の化学合成と生合成
    • Invited
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] 糸状菌Pleosporales sp. RKB3564の生産するpyrrolizilactone生合成経路の解析2019
    • Author(s)
      廣澤 早香、加藤 直樹、野川 俊彦、衣笠 清美、高橋 俊二、長田 裕之
    • Organizer
      日本農芸化学会2019年度大会
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Development of morphology-based screening system of Pyricularia oryzae using AI2019
    • Author(s)
      二村 友史, Rachael Uson-Lopez、山本 甲斐、室井 誠、長田 裕之
    • Organizer
      The 5th CSRS-ITbM Joint Workshop
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Target identification of bioactive small molecules based on proteomic analyses using 2-D DIGE2019
    • Author(s)
      Makoto Muroi, Ikuko Nagasawa, Naoko Ogawa, Harumi Aono, Yushi Futamura, Makoto Kawatani, Hiroyuki Osada
    • Organizer
      RIKEN ? Max Planck Joint Research Center for System Chemical Biology 7th Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06276

  • [Presentation] Functional analysis of Fsa2-family decalin synthase responsible for stereoselective [4+2] cycloaddition2019
    • Author(s)
      Naoki Kato, Toshihiko Nogawa, Ryo Takita, Kiyomi Kinugasa, Hiroyuki Osada, Shunji Takahashi
    • Organizer
      2nd China-Japan Joint Symposium on Natural Product Biosynthesis
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Ring formation in biosynthesis of specialized microbial metabolites2019
    • Author(s)
      Hiroyuki Osada
    • Organizer
      2nd China-Japan Joint Symposium on Natural Product Biosynthesis
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] Morphology-based screening of antitumor and antifungal compounds.2019
    • Author(s)
      Osada, H.
    • Organizer
      8th Annual Conference ICBS-2019
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] 複雑な酸化経路を含むキノコ由来 lagopodin 類の生合成研究2019
    • Author(s)
      桝谷貴洋、平山裕一郎、高西潤、恒松雄太、佐藤道大、大高潤之介、本山高幸、長田裕之、渡辺賢二
    • Organizer
      日本農芸化学会2019年度大会
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] 環化反応を触媒する新規ケトシンターゼドメインのX線結晶構造解析2019
    • Author(s)
      尹 忠銖、西本 一希、本山 高幸、日野 智也、永野 真吾、長田 裕之
    • Organizer
      日本農芸化学会2019年度大会
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Screening of new antifungal compounds based on morphological change of fungi.2019
    • Author(s)
      Osada, H
    • Organizer
      The 2nd International Symposium on Natural Resources-based Drug Development.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] Pyricularia oryzaeにおけるpyriculol類生合成に関わるNADPH-dependent aldo/keto reductase (PYR7) の研究2019
    • Author(s)
      古山祐貴 、本山高幸、野川俊彦、清田洋正、鎌倉高志、長田裕之
    • Organizer
      日本農芸化学会2019年度大会
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] アカデミア創薬の難しさ2019
    • Author(s)
      長田裕之
    • Organizer
      第14回　日本がん分子標的治療学会　TRワークショップ
    • Invited
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] Novel secondary metabolites isolated from the mushroom Coprinopsis cinerea2019
    • Author(s)
      Junnosuke Otaka, Hiroyuki Osada
    • Organizer
      The 1st International Symposium on Chemical Communication (ISCC2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Morphology-based screening of antitumor and antifungal compounds2019
    • Author(s)
      Hiroyuki Osada
    • Organizer
      8th Annual Conference ICBS-2019
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Development of 2DE-CETSA as a novel platform by 2- dimensional electrophoresis based-proteomic analysis for target identification of small molecules2019
    • Author(s)
      Ikuko Nagasawa, Makoto Muroi, Ayumi Ikeno, Naoko Ogawa, Makoto Kawatani, Hiroyuki Osada
    • Organizer
      The lst International Symposium on Chemical Communication (ISCC2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06276

  • [Presentation] リベロマイシン生合成に関わるサクシニル転移酵素の機能解析2019
    • Author(s)
      鬼頭 奈央子、佐藤 裕美、奥村 英夫、熊坂 崇、長田 裕之、高橋 俊二
    • Organizer
      第34回日本放線菌学会大会
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Candida albicansに菌糸形態を誘導する化合物RK-276Aの有機合成2019
    • Author(s)
      山本 甲斐、二村 友史、清水 猛、 Rachael Uson-Lopez、長田 裕之
    • Organizer
      日本農芸化学会2019年度大会
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Biosynthesis of tenuazonic acid in Pyricularia oryzae2019
    • Author(s)
      Hiroyuki Osada
    • Organizer
      The Cold Spring Harbor Asia conference on Chemical Biology and Drug Discovery
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] アカデミア創薬の難しさ2019
    • Author(s)
      長田 裕之
    • Organizer
      第14回　日本がん分子標的治療学会　TRワークショップ
    • Invited
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] 盛岡とケミカルバイオロジー2019
    • Author(s)
      長田 裕之
    • Organizer
      ケミカルバイオロジー特別講演会 in 盛岡
    • Invited
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] A microbial broth library and new compounds from microbes2019
    • Author(s)
      Toshihiko Nogawa, Hiroyuki Osada
    • Organizer
      URICAS Symposium 2019
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Screening of new antifungal antibiotics using artificial intelligence.2019
    • Author(s)
      Osada, H.
    • Organizer
      日中分野別ハイレベル研究者交流会2019：医薬・健康領域
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] 受容体特異的な 3′-alkyl ABA を用いたアブシジン酸受容体機能解析2019
    • Author(s)
      由田 和津子、近藤 恭光、岩橋 福松、中野 雄司、本田 香織、永野 栄喜、長田 裕之
    • Organizer
      植物化学調節学会 第54回大会
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Identification of the pyrrolizilactone biosynthetic gene cluster in Pleosporales sp. RKB35642019
    • Author(s)
      Naoki Kato, Sayaka Hirosawa, Toshihiko Nogawa, Kiyomi Kinugasa, Hiroyuki Osada, Shunji Takahashi
    • Organizer
      The Joint Symposium of 10th Korea-Japan Chemical Biology Symposium and 30th Meeting for New Drug Discovery
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] 2次元電気泳動を用いた化合物に相互作用するたんぱく質の解析法(2DE-CETSA)の開発2019
    • Author(s)
      室井 誠、永澤 生久子、池野 あゆみ、小川 直子、川谷 誠、長田 裕之
    • Organizer
      日本農芸化学会2019年度大会
    • Data Source
      KAKENHI-PROJECT-16H06276

  • [Presentation] イネいもち病菌のネクトリアピロン類の生産誘導と生理機能解析2019
    • Author(s)
      本山高幸、野川 俊彦、長田裕之
    • Organizer
      日本農芸化学会2019年度大会
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] 冬虫夏草（Cordyceps militaris）由来レクチンの機能解析2019
    • Author(s)
      小野晶子 、柏毅、本山高幸、崔宰熏、平井浩文、道羅英夫、長田裕之、河岸洋和、鈴木智大
    • Organizer
      日本農芸化学会2019年度大会
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Tolypocladium albumにおけるNPD938による二次代謝産物生合成遺伝子の発現誘導機構2018
    • Author(s)
      石井友彬、本山高幸、鎌倉高志、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] ケミカルバイオロジー基盤を活用した創薬シードの探索2018
    • Author(s)
      長田裕之
    • Organizer
      講演会「化学が先導するライフ・イノベーション　～医療・創薬研究の最前線～」
    • Invited
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] Chemical Synthesis or Biosynthesis:It is the Question for Reveromycin Production2018
    • Author(s)
      Hiroyuki Osada
    • Organizer
      The Mona Symposium 2018
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] がん代謝を阻害するプレニルフラボノイドの作用機序解析2018
    • Author(s)
      二村友史、青野晴美、佐竹華子、室井誠、川谷誠、野川俊彦、井本正哉、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Timing of the mycotoxin, tenuazonic acid, produciton at the infection of plant pathogenic fungi2018
    • Author(s)
      Hiroyuki Osada
    • Organizer
      The Japanese-German Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] リベロマイシン生合成に関わるサクシニル化酵素群の機能解析2018
    • Author(s)
      鬼頭奈央子、高橋　俊二、佐藤裕美、奥村英夫、熊坂崇、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 担子菌類Coprinopsis cinereaからの新規骨格を有する2種のノルセスキテルペノイド2018
    • Author(s)
      大髙潤之介、二村友史、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 新規アントラキノンkinanthraquinoneの同定と生物活性評価2018
    • Author(s)
      高木海、野川俊彦、二村友史、長田裕之、高橋俊二
    • Organizer
      日本農芸化学会2018年度大会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] マルチオミックス基盤を活用したがん代謝阻害剤の探索2018
    • Author(s)
      長田裕之
    • Organizer
      化学コミュニケーションのフロンティア　第3回公開シンポジウム
    • Invited
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] テヌアゾン酸の環状骨格形成を担うケトシンターゼドメインの結晶化解析2018
    • Author(s)
      尹忠銖、西本一希、本山高幸、日野智也、永野真吾、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 抗生物質学からケミカルバイオロジーへの展開（微生物創薬研究の温故知新）2018
    • Author(s)
      長田　裕之
    • Organizer
      日本技術士会化学部会　2月度 講演会
    • Invited
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] 破骨細胞を標的とするリベロマイシンA：生物活性研究から生合成研究への展開2018
    • Author(s)
      長田裕之
    • Organizer
      日本薬学会第138回年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 抗生物質学からケミカルバイオロジーへの展開（微生物創薬研究の温故知新）2018
    • Author(s)
      長田裕之
    • Organizer
      日本技術士会化学部会　2月度 講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Candida albicansに菌糸形態を誘導する化合物RK-276Aのケミカルバイオロジー研究2018
    • Author(s)
      山本甲斐、二村友史、清水猛、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] がん代謝阻害剤の探索2018
    • Author(s)
      長田裕之
    • Organizer
      愛媛大学大学医学部付属病院先端医療創生センターTRCシリーズセミナー
    • Invited
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] Target identification of compounds isolated from a fraction library of fungal broths2018
    • Author(s)
      Hiroyuki Osada, Toshihiko Nogawa, Yushi Futamura, Makoto Muroi, Naoki Kato
    • Organizer
      3rd European Conference on Natural Products 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Induction of nectriapyrone biosynthesis in the rice blast fungus Pyricularia oryzae2018
    • Author(s)
      Takayuki Motoyama, Toshihiko Nogawa, Hiroyuki Osada
    • Organizer
      3rd European Conference on Natural Products 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] 立体選択的デカリン形成を担うFsa2ファミリーDiels-Alderaseの機能解析2018
    • Author(s)
      加藤直樹、野川俊彦、衣笠清美、高橋俊二、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Crystallization analysis of ketosynthase domain that responsible for cyclic skeleton formation of tenuazonic acid2018
    • Author(s)
      Choong-Soo Yun, Kazuki Nishimoto, Takayuki Motoyama, Tomoya Hino, Shingo Nagano, Hiroyuki Osada
    • Organizer
      The 9th Japan-Korea Chemical Biology Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Anti-osteoclastic agent, reveromycin A (biological activity and biosynthesis)2018
    • Author(s)
      Hiroyuki Osada
    • Organizer
      Department of Chemistry Bicoastal Lecture Series, The Scripps Research Institute
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] Target identification of compounds isolated from a fraction library of fungal broths2018
    • Author(s)
      Hiroyuki Osada, Toshihiko Nogawa, Yushi Futamura, Makoto Muroi, Naoki Kato
    • Organizer
      3rd European Conference on Natural Products 2018
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] [4+2]環化付加反応におけるデカリン合成酵素Fsa2の機能解析2018
    • Author(s)
      加藤 直樹、野川 俊彦、滝田 良、衣笠 清美、金井 美紗衣、内山 真伸、長田 裕之、高橋 俊二
    • Organizer
      第60回天然有機化合物討論会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Chemical synthesis or biosynthesis:It is the question for reveromycin production2018
    • Author(s)
      Hiroyuki Osada
    • Organizer
      The Mona Symposium 2018
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] イネいもち病菌におけるpyriculol類生合成関連aldo/keto reductase遺伝子の機能解析2018
    • Author(s)
      古山祐貴、本山高幸、野川俊彦、清田洋正、鎌倉高志、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] New approach to search and isolate novel secondary metabolites from microbes for a chemical biology study2018
    • Author(s)
      Toshihiko Nogawa and Hiroyuki Osada
    • Organizer
      International Symposium on Himalayan Biodiversity Bioresources
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] がん代謝阻害剤スクリーニングと呼吸阻害作用解析2018
    • Author(s)
      室井誠、二村友史、青野晴美、川谷誠、関根朋美、野川俊彦、林田莉奈、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Systematic Isolation of Microbial Metabolites and the Target Identification2018
    • Author(s)
      Hiroyuki Osada
    • Organizer
      International Symposium on Himalayan Biodiversity Bioresources
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 破骨細胞を標的とするリベロマイシンA：生物活性研究から生合成研究への展開2018
    • Author(s)
      長田　裕之
    • Organizer
      日本薬学会第138回年会
    • Invited
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] がん細胞に活性酸素種産生を誘導する化合物のスクリーニング2018
    • Author(s)
      河村達郎、WILKE Julian、渡辺信元、ZIEGLER Slava、WALDMANN Herbert、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Anti-osteoclastic agent, reveromycin A (biological activity and biosynthesis)2018
    • Author(s)
      Hiroyuki Osada
    • Organizer
      Department of Chemistry Bicoastal Lecture Series, The Scripps Research Institute
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Timing of the mycotoxin, tenuazonic acid, produciton at the infection of plant pathogenic fungi2018
    • Author(s)
      Hiroyuki Osada
    • Organizer
      The Japanese-German Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] デカリン合成酵素遺伝子置換による非天然型天然物誘導体の創出2018
    • Author(s)
      加藤直樹、野川俊彦、衣笠清美、長田裕之、高橋俊二
    • Organizer
      第１８回糸状菌分子生物学コンファレンス
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] がん代謝研究を加速するオミックス解析基盤の構築2018
    • Author(s)
      佐竹華子、二村友史、室井誠、野川俊彦、川谷誠、井本正哉、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Pyrrolizilactone の生合成機構の解析2018
    • Author(s)
      廣澤早香、加藤直樹、衣笠清美、高橋俊二、長田裕之
    • Organizer
      第１８回糸状菌分子生物学コンファレンス
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] Systematic isolation of microbial metabolites and the target identification2018
    • Author(s)
      Hiroyuki Osada
    • Organizer
      International Symposium on Himalayan Biodiversity Bioresources
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] Pyricularia oryzaeにおけるテヌアゾン酸生産誘導化合物の探索と作用機構解析2018
    • Author(s)
      本山高幸、田中陽子、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 糸状菌Pyrenochaetopsis sp. RK10-F058より単離した新規デカリン骨格含有二次代謝産物wakodecaline Cの構造2018
    • Author(s)
      野川俊彦、加藤直樹、清水猛、岡野亜紀子、二村友史、高橋俊二、長田裕之
    • Organizer
      日本農芸化学会2018年度大会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Regulatory mechanism of mycotoxin tenuazonic acid biosynthesis in Pyricularia oryzae2018
    • Author(s)
      Choong-Soo Yun, Takayuki Motoyama, Hiroyuki Osada
    • Organizer
      3rd European Conference on Natural Products 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H03945

  • [Presentation] イネいもち病菌のネクトリアピロン類の生産誘導条件の探索と大量生産株の作製2017
    • Author(s)
      本山 高幸, 田中 陽子, 長田 裕之
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学（京都府京都市）
    • Year and Date
      2017-03-17
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Screening of inhibitors against cancer stem cells from natural products depository (NPDepo)2017
    • Author(s)
      Hiroyuki Osada
    • Organizer
      18th International Symposium on the Biology of Actinomycetes (ISBA18)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] イネいもち病菌におけるピリクロール類生合成に関わるFAD依存性モノオキシゲナーゼ遺伝子の解析2017
    • Author(s)
      古山 祐貴, 本山 高幸, 鎌倉 高志, 野川 俊彦, 長田 裕之
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学（京都府京都市）
    • Year and Date
      2017-03-17
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Biosynthesis and regulatory mechanism of mycotoxin tenuazonic acid in Pyricularia oryzae2017
    • Author(s)
      Choong-Soo Yun, Takayuki Motoyama, Hiroyuki Osada
    • Organizer
      3rd KRIBB-RIKEN Chemical Biology Joint Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Identification of a ligand compound of beta-arrestin as an inhibitor of metastasis of carcinoma associated fibroblasts2017
    • Author(s)
      Kruthi Suvarna, Hiroyuki Osada, Nobumoto Watanabe
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 化合物アレイの新たな活用法：天然物の鏡像体化合物群の活用を目指したスクリーニング法の開発2017
    • Author(s)
      近藤 恭光, 野口 太朗, 大石 真也, 本田 香織, 大野 浩章, 藤井 信孝, 長田 裕之
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学（京都府京都市）
    • Year and Date
      2017-03-17
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] リベロマイシン生合成に関わるRevMの結晶構造解析2017
    • Author(s)
      奥村 英夫, 鬼頭 奈央子, 高橋 俊二, 宮澤 岳, 熊坂 崇, 長田 裕之
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学（京都府京都市）
    • Year and Date
      2017-03-17
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Exploration of novel antifungal substances based on fungal　morphological changes2017
    • Author(s)
      Kai Yamamoto, Yushi Futamura, Takeshi Shimizu, Hiroyuki Osada
    • Organizer
      3rd KRIBB-RIKEN Chemical Biology Joint Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 破骨細胞を標的とするreveromycin Aの研究2017
    • Author(s)
      長田　裕之
    • Organizer
      筑波大学WPIセミナー「有機化学・創薬化学セミナー」
    • Invited
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] 的を射る難しさ2017
    • Author(s)
      長田　裕之
    • Organizer
      第52回 天然物化学談話会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] ケミカルバイオロジーの威力2017
    • Author(s)
      長田　裕之
    • Organizer
      関西学院大学化学セミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Screening of small molecule　inhibitors of human pirin2017
    • Author(s)
      Hiroyuki Osada
    • Organizer
      253rd American Chemical Society National Meeting & Exposition
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Screening of Inhibitors against Cancer Stem Cells from Natural Products Depository (NPDepo)2017
    • Author(s)
      Hiroyuki Osada
    • Organizer
      18th International Symposium on the Biology of Actinomycetes (ISBA18)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Chemical array screening, a powerful approach for exploring small molecule inhibitors against proteins2017
    • Author(s)
      Hiroyuki Osada
    • Organizer
      International Symposium “Systems Glycobiology and Beyond”
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] リベロマイシン生合成に関わる酸化還元酵素RevMの機能解析2017
    • Author(s)
      鬼頭 奈央子, 高橋 俊二, 宮澤 岳, 前島 希, 田中 美帆, 室井 誠. 奥村 英夫, 熊坂 崇, 長田 裕之
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学（京都府京都市）
    • Year and Date
      2017-03-17
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] じゃがいもの新規機能性成分探索に向けたフラクションライブラリーの作製2017
    • Author(s)
      野川 俊彦, 二村 友史, 岡野 亜紀子, 石原 克之, 須藤 麻里, 伊藤 政喜, 長田 裕之
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学（京都府京都市）
    • Year and Date
      2017-03-17
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] New secondary metabolites from Basidiomycete2017
    • Author(s)
      Junnosuke Otaka and Hiroyuki Osada
    • Organizer
      3rd KRIBB-RIKEN Chemical Biology Joint Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Screening and target identification of small molecules affecting cancer metabolism2017
    • Author(s)
      Hiroyuki Osada
    • Organizer
      ICBS 2017
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] Analysis of an FAD-dependent Monooxygenase Gene Involved in Pyriculol Biosynthesis2017
    • Author(s)
      Yuki Furuyama, Takayuki Motoyama, Toshihiko Nogawa, Takashi Kamakura, Hiroyuki Osada
    • Organizer
      3rd KRIBB-RIKEN Chemical Biology Joint Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Novel application of chemical array: Screening approach for drug discovery from natural product enantiomers2017
    • Author(s)
      Yasumitsu Kondoh, Kaori Honda, Taro Noguchi, Shinya Oishi, Hiroaki Ohno, Nobutaka Fujii, and Hiroyuki Osada
    • Organizer
      RIKEN-Max Planck Joint Research Center for System Chemical Biology, The 6th Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 破骨細胞を標的とするreveromycin Aの研究2017
    • Author(s)
      長田裕之
    • Organizer
      筑波大学WPIセミナー「有機化学・創薬化学セミナー」
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] A proteomic profiling, ChemProteoBase, reveals non-proteinous target of compounds2017
    • Author(s)
      Makoto Muroi, Makoto Kawatani, Akira Wada, Miho Tanaka, and Hiroyuki Osada
    • Organizer
      RIKEN-Max Planck Joint Research Center for System Chemical Biology, The 6th Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] がん代謝を標的とする小分子阻害剤の探索2017
    • Author(s)
      長田　裕之、二村　友史、室井　誠
    • Organizer
      第76回日本癌学会学術総会
    • Invited
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] ストレプトマイセス　リベロマイセティカスを用いたテルペノイド生産プラットフォームの開発2017
    • Author(s)
      ＡＭＭＡＲＡ ＫＨＡＬＩＤ, 高木 海, ＳＵＲＥＳＨ ＰＡＮＴＨＥＥ, 長田 裕之, 高橋 俊二
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学（京都府京都市）
    • Year and Date
      2017-03-17
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] グルコース非依存性がん代謝機構を標的とした小分子阻害剤の探索2017
    • Author(s)
      川谷誠、青野晴美、二村友史、室井誠、長田裕之
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Chemical array screening, a powerful approach for exploring small molecule inhibitors against proteins2017
    • Author(s)
      Hiroyuki Osada
    • Organizer
      International Symposium “Systems Glycobiology and Beyond”
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Exploration of small molecules targeting cancer metabolism2017
    • Author(s)
      二村友史、青野晴美、川谷誠、長田裕之
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Artesunate selectively inhibits of cancer stemness through the mitochondrial dysfunction2017
    • Author(s)
      Nobumoto Watanabe, Amit Subedi, Yushi Futamura, Akihide Ryo and Hiroyuki Osada
    • Organizer
      RIKEN-Max Planck Joint Research Center for System Chemical Biology, The 6th Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] ケミカルバイオロジーの威力2017
    • Author(s)
      長田　裕之
    • Organizer
      関西学院大学化学セミナー
    • Invited
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] 植物病原糸状菌の感染戦略におけるテヌアゾン酸生産の関与2017
    • Author(s)
      柏毅、本山高幸、長田裕之
    • Organizer
      平成29年度植物感染生理談話会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Analysis of lucilactaene biosynthesis gene cluster2017
    • Author(s)
      Sho Kato, Takayuki Motoyama, Hiroyuki Osada
    • Organizer
      3rd KRIBB-RIKEN Chemical Biology Joint Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] プレニル化インドールアルカロイドokaramine生合成におけるazetidine環合成酵素の同定2017
    • Author(s)
      加藤 直樹, 大髙 潤之介, 衣笠 清美, 古谷 章悟, 高橋 俊二, 松田 一彦, 長田 裕之
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学（京都府京都市）
    • Year and Date
      2017-03-17
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 的を射る難しさ2017
    • Author(s)
      長田　裕之
    • Organizer
      第52回 天然物化学談話会
    • Invited
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] エネルギー代謝を標的とした小分子化合物の探索2017
    • Author(s)
      二村友史、川谷誠、青野晴美、長田裕之
    • Organizer
      第21回日本がん分子標的治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Structure-activity relationship of NPD9055, a small-molecule inducer of reactive oxygen species2017
    • Author(s)
      Tatsuro Kawamura, Erchang Shang, Gernot Hahne, Sonja Sievers, Slava Ziegler, Nobumoto Watanabe, Herbert Waldmann, Hiroyuki Osada
    • Organizer
      RIKEN-Max Planck Joint Research Center for System Chemical Biology, The 6th Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] アルテスネイトはミトコンドリア障害を介して幹細胞特異的生存阻害を引き起こす2017
    • Author(s)
      渡辺信元、二村友史、長田裕之
    • Organizer
      第21回日本がん分子標的治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Activation of the sleeping gene cluster of microbial secondary metabolites2017
    • Author(s)
      Hiroyuki Osada
    • Organizer
      9th US-Japan Seminar on the Biosynthesis of Natural Products
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] 真菌の形態変化を指標とした抗真菌物質YO15001A、Bの単離2017
    • Author(s)
      山本甲斐、二村友史、長田裕之
    • Organizer
      第32回日本放線菌学会大会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Identification of pyrrolizilactone biosynthetic gene cluster of the fungus RKB35642017
    • Author(s)
      Sayaka Hirosawa, Naoki Kato, Kiyomi Kinugasa, Shunji Takahashi, Hiroyuki Osada
    • Organizer
      3rd KRIBB-RIKEN Chemical Biology Joint Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Pentapeptides from Streptomyces sp. RK88-1441 by using the one strain-many compounds strategy2017
    • Author(s)
      Jun-Pil Jang, Gwi Ja Hwang, Min Cheol Kwon, In-Ja Ryoo, Sung-Kyun Ko, Jae-Hyuk Jang, Hiroyuki Osada, Jong Seong Ahn
    • Organizer
      3rd KRIBB-RIKEN Chemical Biology Joint Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] ChemProteoBase を用いた化合物のオフターゲット解析2017
    • Author(s)
      室井誠、川谷誠、河村達郎、近藤恭光、二村友史、田中美帆、青野晴美、本田香織、長田裕之
    • Organizer
      日本ケミカルバイオロジー学会　第12回年会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] リベロマイシン生合成に関わるRevMの機能解析2017
    • Author(s)
      鬼頭奈央子、高橋俊二、佐藤裕美、奥村英夫、熊坂崇、長田裕之
    • Organizer
      第32回日本放線菌学会大会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Activation of the sleeping gene cluster of microbial secondary metabolites2017
    • Author(s)
      Hiroyuki Osada
    • Organizer
      9th US-Japan Seminar on the Biosynthesis of Natural Products
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 抗生物質学からケミカルバイオロジーへの展開（微生物創薬研究の温故知新）2017
    • Author(s)
      長田　裕之
    • Organizer
      ライフサイエンス技術部会・反応分科会　講演会
    • Invited
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] グルコース非依存性がん代謝機構を標的とした小分子阻害剤の探索2017
    • Author(s)
      川谷誠、青野晴美、二村友史、室井誠、長田裕之
    • Organizer
      第21回日本がん分子標的治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Fsa2-family Diels-Alderases are responsible for the stereoselective decaline formation2017
    • Author(s)
      Naoki Kato, Toshihiko Nogawa, Kiyomi Kinugasa, Shunji Takahashi, Hiroyuki Osada
    • Organizer
      3rd KRIBB-RIKEN Chemical Biology Joint Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 糸状菌Pyrenochaetopsis sp. RK10-F058より単離した新規デカリン骨格含有二次代謝産物の構造2017
    • Author(s)
      野川俊彦、加藤直樹、清水猛、岡野亜紀子、二村友史、高橋俊二、長田裕之
    • Organizer
      第59回天然有機化合物討論会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] がん代謝を標的とする小分子阻害剤の探索2017
    • Author(s)
      長田裕之、二村友史、室井誠
    • Organizer
      第76回日本癌学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] がん細胞に誘起される繊維芽細胞遊走を阻害する小分子探索2017
    • Author(s)
      渡辺信元、Kruthi Suvarna、本田香織、近藤恭光、長田裕之
    • Organizer
      2107年度生命科学系学会合同年次大会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Application of a fraction library for new metabolites search2017
    • Author(s)
      Toshihiko Nogawa, Akiko Okano, Yushi Futamura, Takeshi Shimizu, Nobumoto Watanabe, Shunji Takahashi, Hiroyuki Osada
    • Organizer
      3rd KRIBB-RIKEN Chemical Biology Joint Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Screening of small molecule inhibitors of human pirin2017
    • Author(s)
      Hiroyuki Osada
    • Organizer
      253rd American Chemical Society National Meeting & Exposition
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06412

  • [Presentation] 植物病原糸状菌が生産する二次代謝産物テヌアゾン酸は宿主の抵抗性を誘導する2017
    • Author(s)
      柏毅、本山高幸、長田裕之
    • Organizer
      平成29年度日本植物病理学会大会
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Identification of novel anthraquinone biosynthetic gene cluster2017
    • Author(s)
      Risa Takao, Naoko Kito, Hiroshi Takagi, Hiroyuki Osada, Shunji Takahashi
    • Organizer
      3rd KRIBB-RIKEN Chemical Biology Joint Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Screening and target identification of small molecules affecting cancer metabolism2017
    • Author(s)
      Hiroyuki Osada
    • Organizer
      ICBS 2017
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Inhibitor of stromal fibroblast migration accelerated by cancer cells2017
    • Author(s)
      Kruthi Suvarna, Kaori Honda, Yasumitsu Kondoh, Hiroyuki Osada, Nobumoto Watanabe
    • Organizer
      3rd KRIBB-RIKEN Chemical Biology Joint Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] じゃがいもフラクションライブラリーを用いた抗糖化活性の検討2017
    • Author(s)
      須藤 麻里, 吉原 潮梨, 石原 克之, 野川 俊彦, 二村 友史, 岡野 亜紀子, 長田 裕之
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学（京都府京都市）
    • Year and Date
      2017-03-17
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 抗生物質学からケミカルバイオロジーへの展開（微生物創薬研究の温故知新）2017
    • Author(s)
      長田裕之
    • Organizer
      ライフサイエンス技術部会・反応分科会　講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 酸化ヌクレオチド加水分解酵素MTH1阻害剤の作用解析2016
    • Author(s)
      川谷 誠, 河村 達郎, 室井 誠, 青野 晴美, 二村 友史, 田中 美帆, 長田 裕之
    • Organizer
      第20回日本がん分子標的治療学会学術集会
    • Place of Presentation
      別府国際コンベンションセンター（大分県別府市）
    • Year and Date
      2016-05-30
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Analysis of MTH1 inhibitors by ChemProteoBase, the drug-target analysis system based on proteomic profiling.2016
    • Author(s)
      Muroi M, Kawatani M, Kawamura T, Futamura Y, Osada H
    • Organizer
      The 21st JFCR-International Symposium on Cancer Chemotherapy (JFCR-ISCC)
    • Place of Presentation
      Miraikan (National Museum of Emerging Science and Innovation) (Tokyo, Japan)
    • Year and Date
      2016-12-14
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Phenotypic screening of small molecules targeting cancer metabolism2016
    • Author(s)
      Futamura Y, Kawatani M, Aono H, Muroi M, Tanaka M, Osada H
    • Organizer
      The 8th Korea-Japan Chemical Biology symposium
    • Place of Presentation
      Okinawa Institute of Science and Technology Graduate University （Naha, Okinawa, Japan）
    • Year and Date
      2016-01-19
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 14-3-3 protein-porotein interaction inhibitors identified by high throughput screening2016
    • Author(s)
      Watanabe N, Osada H
    • Organizer
      RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 5th Symposium
    • Place of Presentation
      Harnack-Haus, Tagungsstatte der Max-Planck-Gesellschaft (Berlin, Germany)
    • Year and Date
      2016-04-17
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 真菌の形態変化を指標とした抗真菌物質の探索研究2016
    • Author(s)
      山本 甲斐, 二村 友史, 植木 雅志, 鈴木 龍一郎, 白瀧 義明, 長田裕之
    • Organizer
      日本農芸化学会 2016年度大会
    • Place of Presentation
      札幌コンベンションセンター 札幌市産業振興センター （北海道札幌市)
    • Year and Date
      2016-03-27
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] イネいもち病菌のピリクロール類生合成遺伝子クラスターの同定2016
    • Author(s)
      古山 祐貴, 本山 高幸, 鎌倉 高志, 長田裕之
    • Organizer
      日本農芸化学会 2016年度大会
    • Place of Presentation
      札幌コンベンションセンター 札幌市産業振興センター （北海道札幌市)
    • Year and Date
      2016-03-27
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] エネルギー代謝プロファイリングを用いたがん代謝阻害剤の探索研究2016
    • Author(s)
      二村 友史, 青野 晴美, 川谷 誠, 室井 誠, 長田 裕之
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜（神奈川県横浜市）
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ2016
    • Author(s)
      Kondoh Y, Honda K, Hiranuma S, Shimizu T, Osada H
    • Organizer
      RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 5th Symposium
    • Place of Presentation
      Harnack-Haus, Tagungsstatte der Max-Planck-Gesellschaft (Berlin, Germany)
    • Year and Date
      2016-04-17
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Characterization of middle chain fatty acyl-CoA ligase responsible for the biosynthesis of 2-alkylmalonyl-CoAs for polyketide extender unit2016
    • Author(s)
      Miyazawa H, Takahashi S, Shimizu T, Nogawa T, Osada H
    • Organizer
      The 8th Korea-Japan Chemical Biology symposium
    • Place of Presentation
      Okinawa Institute of Science and Technology Graduate University （Naha, Okinawa, Japan）
    • Year and Date
      2016-01-19
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Stereospecific ring formation in biosynthesis of specialized microbial metabolites2016
    • Author(s)
      Osada H
    • Organizer
      17th Tetrahedron Symposium
    • Place of Presentation
      MeliaSitges Hotel Congress Centre (Sitges, Barcelona, Spain)
    • Year and Date
      2016-06-29
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] フサリセチンAの特徴的な環構造形成を担う環化酵素の同定2016
    • Author(s)
      加藤 直樹, 衣笠 清美，Jae-Hyuk JANG，高橋 俊二，Jong Seog AHN，長田 裕之
    • Organizer
      第16回糸状菌分子生物学コンファレンス
    • Place of Presentation
      宇治おうばくプラザ（京都大学宇治キャンパス内）（京都府宇治市）
    • Year and Date
      2016-11-17
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] リン酸化特異的プロリン異性化酵素Pin1の新規阻害小分子の単離2016
    • Author(s)
      渡邉 信元, 長田 裕之
    • Organizer
      第20回日本がん分子標的治療学会学術集会
    • Place of Presentation
      別府国際コンベンションセンター（大分県別府市）
    • Year and Date
      2016-05-30
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Discovery of a new enzyme involved in the stereoselective decalin formation during equisetin biosynthesis2016
    • Author(s)
      Kato N, Nogawa T, Hirota H, Takahashi S, Jang JH, Ahn JS, Osada H
    • Organizer
      The 8th Korea-Japan Chemical Biology symposium
    • Place of Presentation
      Okinawa Institute of Science and Technology Graduate University （Naha, Okinawa, Japan）
    • Year and Date
      2016-01-19
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Bioactive compounds from Plant Roots2016
    • Author(s)
      Otaka J, Futamura Y, Osada H
    • Organizer
      The 8th Korea-Japan Chemical Biology symposium
    • Place of Presentation
      Okinawa Institute of Science and Technology Graduate University （Naha, Okinawa, Japan）
    • Year and Date
      2016-01-19
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 放線菌Streptomyces sp. RK88-1355より単離した新規Opantimycin Aの構造2016
    • Author(s)
      野川 俊彦, リム・チュンリャン, 岡野 亜紀子, 二村 友史, 清水 猛, 高橋 俊二, 長田 裕之
    • Organizer
      第58回天然有機化合物討論会
    • Place of Presentation
      東北大学（宮城県仙台市）
    • Year and Date
      2016-09-14
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Activation of fungal secondary metabolism by disturbance of the two-component signal transduction system and identification of the nectriapyrone biosynthetic gene cluster2016
    • Author(s)
      Motoyama T, Tanaka Y, Osada H
    • Organizer
      9th Joint Natural Products Conference 2016
    • Place of Presentation
      Tivoli Congress Centre (Copenhagen, Denmark)
    • Year and Date
      2016-07-26
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Discovery and analyses of 14-3-3 protein-protein interaction inhibitors identified by high throughput screening2016
    • Author(s)
      Nobumoto Watanabe, Hiroyuki Osada
    • Organizer
      Tenth AACR-JCA Joint Conference on Breakthroughs in Cancer Research: From Biology to Therapeutics
    • Place of Presentation
      Hyatt Regency Maui （Maui, Hawaii, USA）
    • Year and Date
      2016-02-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] プレニル化インドールアルカロイドokaramineの遺伝学的手法による生合成経路解析2016
    • Author(s)
      加藤 直樹, 古谷 章悟, 大髙 潤之介, 衣笠 清美, 高橋 俊二, 松田 一彦, 長田 裕之
    • Organizer
      日本農芸化学会 2016年度大会
    • Place of Presentation
      札幌コンベンションセンター 札幌市産業振興センター （北海道札幌市)
    • Year and Date
      2016-03-27
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival2016
    • Author(s)
      Kawamura T, Kawatani M, Muroi M, Kondoh Y, Futamura Y, Aono H, Tanakaa M, Honda K, Osada H
    • Organizer
      28th EORTC-NCI-AACR SYMPOSIUM
    • Place of Presentation
      ICM - Internationales Congress Center Munich (Munich, Germany)
    • Year and Date
      2016-11-30
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] アルテスネイトはミトコンドリアを標的として、肝細胞特異的にがん細胞生存を阻害する2016
    • Author(s)
      渡辺 信元, Amit Sbedi, 二村 友史, 梁明秀, 長田 裕之
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜（神奈川県横浜市）
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Expansion of ChemProteoBase for the analysis of compounds affecting cancer metabolism2016
    • Author(s)
      Muroi M, Tanaka M, Osada H
    • Organizer
      RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 5th Symposium
    • Place of Presentation
      Harnack-Haus, Tagungsstatte der Max-Planck-Gesellschaft (Berlin, Germany)
    • Year and Date
      2016-04-17
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] イネいもち病菌におけるカビ毒テヌアゾン酸の生合成2016
    • Author(s)
      尹 忠銖, 本山 高幸, 長田 裕之
    • Organizer
      第59回 日本放線菌学会学術講演会
    • Place of Presentation
      東京電機大学 (東京都足立区)
    • Year and Date
      2016-03-07
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 微生物フラクションライブラリーより単離した新規ネオアンチマイシン類縁体ウナンチマイシンAの構造2016
    • Author(s)
      野川 俊彦, リム・チュンリャン, 岡野 亜紀子, 二村 友史, 川谷 誠, 高橋 俊二, ダーラ・イブラヒム, 長田裕之
    • Organizer
      日本農芸化学会 2016年度大会
    • Place of Presentation
      札幌コンベンションセンター 札幌市産業振興センター （北海道札幌市)
    • Year and Date
      2016-03-27
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] カビ由来新規NRPS-PKS融合酵素によるカビ毒テヌアゾン酸の生合成2016
    • Author(s)
      尹 忠銖, 本山 高幸, 長田 裕之
    • Organizer
      日本農芸化学会 2016年度大会
    • Place of Presentation
      札幌コンベンションセンター 札幌市産業振興センター （北海道札幌市)
    • Year and Date
      2016-03-27
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 化合物アレイ法による医薬シードの探索2016
    • Author(s)
      長田 裕之
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      東北大学（宮城県仙台市）
    • Year and Date
      2016-09-25
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Screening of small molecule compounds with activity to selectively inhibit the cancer stem cell properties2016
    • Author(s)
      Hiroyuki Osada
    • Organizer
      Tenth AACR-JCA Joint Conference on Breakthroughs in Cancer Research: From Biology to Therapeutics
    • Place of Presentation
      Hyatt Regency Maui （Maui, Hawaii, USA）
    • Year and Date
      2016-02-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] ChemProteoBaseによるがん代謝作用薬の解析2016
    • Author(s)
      室井 誠, 田中 美帆, 長田 裕之
    • Organizer
      日本農芸化学会 2016年度大会
    • Place of Presentation
      札幌コンベンションセンター 札幌市産業振興センター （北海道札幌市)
    • Year and Date
      2016-03-27
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] エネルギー代謝プロファイリングを用いたがん代謝阻害薬の探索研究2016
    • Author(s)
      二村 友史, 川谷 誠, 青野 晴美, 室井 誠, 田中 美帆, 長田 裕之
    • Organizer
      第20回日本がん分子標的治療学会学術集会
    • Place of Presentation
      別府国際コンベンションセンター（大分県別府市）
    • Year and Date
      2016-05-30
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Identification of MTH1inhibitors by chemical arrays2016
    • Author(s)
      Kawamura T, Kawatani M, Kondoh Y, Muroi M, Futamura Y, Aono H, Tanaka M, Honda K, Osada H
    • Organizer
      RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 5th Symposium
    • Place of Presentation
      Harnack-Haus, Tagungsstatte der Max-Planck-Gesellschaft (Berlin, Germany)
    • Year and Date
      2016-04-17
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Fragment arrays for early druggability assessments2016
    • Author(s)
      Jonas Aretz, Yasumitsu Kondoh, Kaori Honda, Upendra Rao Anumala, Marc Nazare, Nobumoto Watanabe, Hiroyuki Osada, Christoph Rademacher
    • Organizer
      RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 5th Symposium
    • Place of Presentation
      Harnack-Haus, Tagungsstatte der Max-Planck-Gesellschaft (Berlin, Germany)
    • Year and Date
      2016-04-17
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Characterization of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival2016
    • Author(s)
      河村 達郎, 川谷 誠, 室井 誠, 青野 晴美, 二村 友史, 長田 裕之
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜（神奈川県横浜市）
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Chemical array screening of matrix metalloproteinase inhibitors2016
    • Author(s)
      近藤 恭光, 川谷 誠, 本田 香織, 関根 朋美, 長田 裕之
    • Organizer
      日本農芸化学会 2016年度大会
    • Place of Presentation
      札幌コンベンションセンター 札幌市産業振興センター （北海道札幌市)
    • Year and Date
      2016-03-27
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 抗生物質学のすすめ2016
    • Author(s)
      長田 裕之
    • Organizer
      第42回 農芸化学「化学と生物」シンポジウム
    • Place of Presentation
      札幌市教育文化会館 （北海道札幌市)
    • Year and Date
      2016-03-27
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 分子標的治療薬開発の落とし穴2016
    • Author(s)
      長田 裕之
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜（神奈川県横浜市）
    • Year and Date
      2016-10-06
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Comparative chemical array screening of p38γ/δ MAPK inhibitors by focusing on a single gatekeeper residue difference between p38α/β and p38γ/δ2016
    • Author(s)
      Kondoh Y, Honda K, Hiranuma S, Shimizu T, Osada H
    • Organizer
      17th Tetrahedron Symposium
    • Place of Presentation
      MeliaSitges Hotel Congress Centre (Sitges, Barcelona, Spain)
    • Year and Date
      2016-06-30
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme2016
    • Author(s)
      Yun CS, Motoyama T, Osada H
    • Organizer
      The 8th Korea-Japan Chemical Biology symposium
    • Place of Presentation
      Okinawa Institute of Science and Technology Graduate University （Naha, Okinawa, Japan）
    • Year and Date
      2016-01-19
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] The role of the MTH1 enzyme in cancer gave rise to controversy2016
    • Author(s)
      Kawamura T, Kawatani M, Osada H
    • Organizer
      The First Asian 3 Roundtable Meeting on Chemical Probe Research Hub
    • Place of Presentation
      Hotel LEOPALACE Hakata (Fukuoka, Japan)
    • Year and Date
      2016-09-22
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Multidimensional approach for drug discovery and target identification2015
    • Author(s)
      Hiroyuki Osada
    • Organizer
      Drug Screening and Discovery Technologies Asian Forum 2015
    • Place of Presentation
      InterContinental Shanghai Pudong Hotel (Shanghai, China)
    • Year and Date
      2015-01-22
    • Invited
    • Data Source
      KAKENHI-PROJECT-24248022

  • [Presentation] モルフォベースを基盤とした抗がん物質探索：特異な線状構造体を誘導するNPD4152の発見2015
    • Author(s)
      二村 友史, 川谷 誠, 室井 誠, 青野 晴美, 長田 裕之
    • Organizer
      第19回日本がん分子標的治療学会学術集会
    • Place of Presentation
      松山全日空ホテル （愛媛県松山市）
    • Year and Date
      2015-06-10
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] リン酸化依存タンパク質間相互作用阻害による細胞周期停止の解析2015
    • Author(s)
      渡辺 信元, Amit Subedi, 長田 裕之
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場 （愛知県名古屋市）
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Discovery and target identification of pyrrolizilactone, a fungal metabolite2015
    • Author(s)
      Hiroyuki Osada, Yushi Futamura, Toshihiko Nogawa
    • Organizer
      The international chemical congress of pacific basin societies (Pacifichem) 2015
    • Place of Presentation
      Hawaii Convention Center 他 （Honolulu, Hawaii, USA）
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] エストロゲン受容体制御分子BIG3を標的とした新規ER陽性乳がん治療法2015
    • Author(s)
      吉丸哲郎、小松正人、田代　悦、長田裕之、井本正哉、豊國伸哉、三好康雄、笹　三徳、片桐豊雅
    • Organizer
      第７４回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場、愛知県名古屋市
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-221S0001

  • [Presentation] Iolation of new metabolites from a microbial metabolites fraction library by NPPlot screening2015
    • Author(s)
      Toshihiko Nogawa, Akiko Okano, Jang Jun-Pil, Takeshi Shimizu, Shunji Takahashi, Hiroyuki Osada
    • Organizer
      The international chemical congress of pacific basin societies (Pacifichem) 2015
    • Place of Presentation
      Hawaii Convention Center 他 （Honolulu, Hawaii, USA）
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Biosynthesis study aiming at creation of an anti-osteoclast drug2015
    • Author(s)
      Hiroyuki Osada, Toshihiko Nogawa, Shunji Takahashi
    • Organizer
      The international chemical congress of pacific basin societies (Pacifichem) 2015
    • Place of Presentation
      Hawaii Convention Center 他 （Honolulu, Hawaii, USA）
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 新たなNRPS-PKS融合酵素によるかび毒テヌアゾン酸の生合成2015
    • Author(s)
      尹 忠銖, 本山 高幸, 長田 裕之
    • Organizer
      第15回糸状菌分子生物学コンファレンス
    • Place of Presentation
      ルミエール府中 （東京都府中市）
    • Year and Date
      2015-11-19
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Screening of novel antimalarial agents2015
    • Author(s)
      Hiroyuki Osada
    • Organizer
      Finding Strengthening Plan of Global Network on Science, Technology and ICT, with the OECD Ministerial Meeting Daejeon 2015
    • Place of Presentation
      Daejeon Convention Center （Daejeon, Korea）
    • Year and Date
      2015-10-20
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Streptomyces reveromyceticusにおけるテルペノイド生合成プラットフォーム2015
    • Author(s)
      シュレス パンテー, アマラ カーリッド, 高木 海, 白井 智量, 近藤 昭彦, 長田 裕之, 高橋 俊二
    • Organizer
      2015年度（第30回）日本放線菌学会大会
    • Place of Presentation
      富山国際会議場 （富山県富山市）
    • Year and Date
      2015-09-07
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 抗生物質研究からケミカルバイオロジー研究へ2015
    • Author(s)
      長田 裕之
    • Organizer
      メディカル・サイエンス セミナー（最近話題の微生物のはなし）
    • Place of Presentation
      学士会館 （東京都千代田区)
    • Year and Date
      2015-07-08
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 化合物アレイによる創薬シードの探索2015
    • Author(s)
      長田 裕之
    • Organizer
      日本薬学会関東支部第40回学術講演会　創薬イノベーションを支える最先端サイエンス
    • Place of Presentation
      日本薬学会長井記念館　長井記念ホール (東京都渋谷区)
    • Year and Date
      2015-12-26
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Screening of Antimicrobial Agents in NPDepo2015
    • Author(s)
      Hiroyuki Osada
    • Organizer
      RIKEN-Academia Sinica Joint Conference on Chemical Biology
    • Place of Presentation
      Genomics Research Center, Academia Sinica （Taipei, Taiwan）
    • Year and Date
      2015-10-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] フラクションライブラリーとスペクトルデータベースを利用した新規化合物探索2015
    • Author(s)
      野川 俊彦, Jang Jun-Pil, Lim Chung Liang, 岡野 亜紀子, 本郷 やよい, 中村 健道, 清水 猛, 高橋 俊二, 長田 裕之
    • Organizer
      第63回質量分析総合討論会
    • Place of Presentation
      つくば国際会議場エポルカつくば （茨城県つくば市）
    • Year and Date
      2015-06-17
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] エキセチン生合成における立体選択的なデカリン環形成に関わる新規酵素遺伝子fsa2の発見2015
    • Author(s)
      加藤 直樹, 野川 俊彦, 廣田 洋, 高橋 俊二, Jae-Hyuk Jang, Jong Seog Ahn, 長田 裕之
    • Organizer
      第57回天然有機化合物討論会
    • Place of Presentation
      神奈川県民ホール （神奈川県横浜市）
    • Year and Date
      2015-09-09
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 糸状菌二次代謝を標的とした農薬探索2015
    • Author(s)
      本山 高幸, 尹 忠銖, 長田 裕之
    • Organizer
      BMB2015 第38回 日本分子生物学会, 第88回 日本生物化学会大会
    • Place of Presentation
      神戸ポートアイランド (兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 昆虫制御活性物質オカラミンの生合成遺伝子クラスターの同定2015
    • Author(s)
      加藤 直樹, 古谷 章悟，衣笠 清美，高橋 俊二，松田 一彦，長田 裕之
    • Organizer
      第15回糸状菌分子生物学コンファレンス
    • Place of Presentation
      ルミエール府中 （東京都府中市）
    • Year and Date
      2015-11-19
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 分子標的治療を目指したタンパク質間相互作用阻害剤の探索2015
    • Author(s)
      長田 裕之
    • Organizer
      第795回千葉県がんセンター研究所集談会
    • Place of Presentation
      千葉県がんセンター （千葉県千葉市）
    • Year and Date
      2015-07-06
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] ポリケチド伸長単位生合成に関与する脂肪酸活性化酵素の機能解析2015
    • Author(s)
      宮澤 岳, 高橋 俊二, 長田 裕之
    • Organizer
      2015年度（第30回）日本放線菌学会大会
    • Place of Presentation
      富山国際会議場 （富山県富山市）
    • Year and Date
      2015-09-07
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Discovery of NP428 as selective tumorsphere inhibitor2015
    • Author(s)
      Subedi Amit, Nobumoto Watanabe, Mayuko Nishii, Akihide Ryo, Hiroyuki Osada
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場 （愛知県名古屋市）
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 化合物アレイを用いた新規MTH1阻害剤の探索2015
    • Author(s)
      河村 達郎, 川谷 誠, 長田 裕之
    • Organizer
      第19回日本がん分子標的治療学会学術集会
    • Place of Presentation
      松山全日空ホテル （愛媛県松山市）
    • Year and Date
      2015-06-10
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] A new enzyme involved in the control of the stereochemistry in the decalin formation during equisetin biosynthesis2015
    • Author(s)
      Naoki Kato, Toshihiko Nogawa, Hiroshi Hirota, Shunji Takahashi, Jae-Hyuk Jang, Jong Seog Ahn, Hiroyuki Osada
    • Organizer
      The international chemical congress of pacific basin societies (Pacifichem) 2015
    • Place of Presentation
      Hawaii Convention Center 他 （Honolulu, Hawaii, USA）
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Chemical array screen identifies a novel MMP inhibitor NPDK-18 that suppresses tumor cell migration2015
    • Author(s)
      Makoto Kawatani, Yasumitsu Kondoh, Kaori Honda, Tomomi Sekine, Hiroyuki Osada
    • Organizer
      AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      Hynes Convention Center （Boston, USA）
    • Year and Date
      2015-11-05
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Characterization of fatty acyl-CoA ligase for the biosynthesis of the extender unit of reveromycin A2015
    • Author(s)
      Shunji Takahashi, Takeshi Miyazawa, Hiroyuki Osada
    • Organizer
      The international chemical congress of pacific basin societies (Pacifichem) 2015
    • Place of Presentation
      Hawaii Convention Center 他 （Honolulu, Hawaii, USA）
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 創農薬を志向したケミカルバイオロジー研究2015
    • Author(s)
      長田 裕之
    • Organizer
      第2回 グリーン科学技術研究所シンポジウム
    • Place of Presentation
      グリーン科学技術研究所 (静岡県静岡市)
    • Year and Date
      2015-11-17
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] MorphobaseおよびChemProteoBaseを用いたGN.9482の標的同定2015
    • Author(s)
      青野 晴美, 川谷 誠, 二村 友史, 室井 誠, 峯岸 秀充, 中村 浩之, 長田 裕之
    • Organizer
      第19回日本がん分子標的治療学会学術集会
    • Place of Presentation
      松山全日空ホテル （愛媛県松山市）
    • Year and Date
      2015-06-10
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 遺伝子破壊実験によるテロメスタチン生合成遺伝子クラスターの同定2015
    • Author(s)
      天貝 啓太, 工藤 史貴, 江口 正, 長田 裕之, 池田 治生, 新家 一男, 高橋 俊二
    • Organizer
      2015年度（第30回）日本放線菌学会大会
    • Place of Presentation
      富山国際会議場 （富山県富山市）
    • Year and Date
      2015-09-07
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] がん代謝作用薬解析におけるChemProteoBaseの利用2015
    • Author(s)
      室井 誠、田中 美帆、川谷 誠、長田 裕之
    • Organizer
      第19回日本がん分子標的治療学会学術集会
    • Place of Presentation
      松山全日空ホテル （愛媛県松山市）
    • Year and Date
      2015-06-10
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] Screening of Novel Antimalarial Agents in RIKEN NPDepo2015
    • Author(s)
      Hiroyuki Osada
    • Organizer
      Finding Strengthening Plan of Global Network on Science, Technology and ICT, with the OECD Ministerial Meeting Daejeon 2015
    • Place of Presentation
      Daejeon Convention Center （Daejeon, Korea）
    • Year and Date
      2015-10-20
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] リベロマイシン生合成機構の解析2015
    • Author(s)
      高橋 俊二, 長田 裕之
    • Organizer
      第67回日本生物工学会大会
    • Place of Presentation
      城山観光ホテル (鹿児島県鹿児島市)
    • Year and Date
      2015-10-26
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] 抗生物質研究を起源とするケミカルバイオロジー研究2015
    • Author(s)
      長田 裕之
    • Organizer
      日本農芸化学会関東支部2015年度第2回支部例会
    • Place of Presentation
      東京大学弥生講堂 一条ホール （東京都文京区）
    • Year and Date
      2015-12-12
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H02445

  • [Presentation] New OxindoleDerivatives Isolated from the Microbial Metabolite Fraction Library of Streptomyces sp. RK85-2702014
    • Author(s)
      Jun-Pil Jang, Toshihiko Nogawa, Masakazu Uramoto, Akiko Okano, Yushi Futamura, Takeshi Shimizu, Shunji Takahashi, Jae-Hyuk Jang, Jong Seog Ahn, Hiroyuki Osada
    • Organizer
      The 7th Japan-Korea Chemial Biology Symposium
    • Place of Presentation
      Ramada Hotel (Jeju, Korea)
    • Data Source
      KAKENHI-PROJECT-24248022

  • [Presentation] NPD926, a small molecule inducer of reactive oxygen species, kills cancer cells via glutathione depletion2014
    • Author(s)
      河村達郎、近藤恭光、室井誠、川谷誠、長田裕之
    • Organizer
      26th EORTC-NCI-AACR Symposium on Molecular Targets & Cancer Therapeutics
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-11-19
    • Data Source
      KAKENHI-PROJECT-221S0001

  • [Presentation] 天然物創薬を目指して2014
    • Author(s)
      長田 裕之
    • Organizer
      静岡大学農学部公開講演会（第214回 静岡ライフサイエンスセミナー）
    • Place of Presentation
      静岡大学農学部 （静岡県）
    • Year and Date
      2014-09-16
    • Invited
    • Data Source
      KAKENHI-PROJECT-24248022

  • [Presentation] Intenational Collaboration on Chemical Biology: How to Pass a Baton to the Future2014
    • Author(s)
      Hiroyuki Osada
    • Organizer
      The 7th Japan-Korea Chemial Biology Symposium
    • Place of Presentation
      Ramada Hotel (Jeju, Korea)
    • Data Source
      KAKENHI-PROJECT-24248022

  • [Presentation] Isolation and target identification of pyrrolizilactone2014
    • Author(s)
      Hiroyuki Osada
    • Organizer
      2014 Osong International Bio Industry Exposition
    • Place of Presentation
      Osong Bio Valley (Osong, Korea)
    • Year and Date
      2014-10-07
    • Invited
    • Data Source
      KAKENHI-PROJECT-24248022

  • [Presentation] Isolation and target identification of pyrrolizilactone2014
    • Author(s)
      長田裕之
    • Organizer
      2014 Osong International Symposium
    • Place of Presentation
      Osong, Korea
    • Year and Date
      2014-10-07
    • Data Source
      KAKENHI-PROJECT-221S0001

  • [Presentation] 理化学研究所天然化合物(NPDepo)が提供する創薬研究支援2014
    • Author(s)
      斎藤臣雄、近藤恭光、長田裕之
    • Organizer
      文科省新学術領域研究・がん支援「化学療法基盤支援活動」第三回シンポジウムアカデミアからの抗がん剤創薬に向けて-天然物の有効利用
    • Place of Presentation
      万国津梁館(沖縄県・名護市)
    • Year and Date
      2014-05-12
    • Data Source
      KAKENHI-PROJECT-221S0001

  • [Presentation] 糸状菌Fusarium sp. RK97-94のルシラクタエン生合成遺伝子クラスターの解析2014
    • Author(s)
      加藤 翔, 本山 高幸, 林 敏明, 廣田 洋, 鎌倉 高志, 長田 裕之
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学 生田キャンパス（神奈川県）
    • Data Source
      KAKENHI-PROJECT-24248022

  • [Presentation] ChemProteoBaseによるcollismycin Aの作用機作解析2014
    • Author(s)
      室井 誠, 近藤 久恵, 平田 泰子, 井上 尭, 川谷 誠, 長田 裕之
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学 生田キャンパス（神奈川県）
    • Data Source
      KAKENHI-PROJECT-24248022

  • [Presentation] Cell cycle inhibitors targeting Achilles heels of cells2014
    • Author(s)
      Hiroyuki Osada
    • Organizer
      Asian Biological Medicine Summit Forum in Hangzhou: The International Symposium on Natural Products Chemistry and Chemical Biology 2014 & ACBI 2014 Hangzhou Meeting
    • Place of Presentation
      Hangzhou Shujian Hotel (Hangzhou, China)
    • Year and Date
      2014-11-24
    • Invited
    • Data Source
      KAKENHI-PROJECT-24248022

  • [Presentation] ケミカルバイオロジーによる創農薬の可能性2014
    • Author(s)
      長田 裕之
    • Organizer
      東京農業大学総合研究所　農薬部会 （第95回セミナー）
    • Place of Presentation
      東京農業大学 総合研究所 （東京都）
    • Year and Date
      2014-10-03
    • Invited
    • Data Source
      KAKENHI-PROJECT-24248022

  • [Presentation] in vitro Reconstitution of Biosynthetic Machinery for Reveromycin2014
    • Author(s)
      Hiroyuki Osada, Shunji Takahashi
    • Organizer
      XVII. International Symposium on the Biology of Actinomycetes
    • Place of Presentation
      Pine Bay Holiday Resort (Izmir, Turkey)
    • Year and Date
      2014-10-10
    • Invited
    • Data Source
      KAKENHI-PROJECT-24248022

  • [Presentation] 放線菌由来抗がん性物質 collismycin A の作用標的同定2014
    • Author(s)
      井上 尭, 川谷 誠, 室井 誠, 二村 友史, 青野 晴美, 浦本 昌和, 本郷 やよい, 越野 広雪, 五十嵐 康弘, 安藤 直子, 長田 裕之
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学 生田キャンパス（神奈川県）
    • Data Source
      KAKENHI-PROJECT-24248022

  • [Presentation] NPPlot（Natural Products Plot）を用いた新規微生物代謝産物の探索と単離2014
    • Author(s)
      野川 俊彦, リム チュン・リャン, 浦本 昌和, 岡野 亜紀子, 本郷 やよい, 中村 健道, 越野 広雪, 高橋 俊二, イブラヒム ダーラ, 長田 裕之
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学 生田キャンパス（神奈川県）
    • Data Source
      KAKENHI-PROJECT-24248022

  • [Presentation] 微生物培養ブロスからの抗マラリア活性化合物の探索2014
    • Author(s)
      早瀬 大貴, 宇賀田 久美子, LIM Chung Liang, 二村 友史, 野川 俊彦, 渡邉 信元, 北 潔, 長田 裕之
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学 生田キャンパス（神奈川県）
    • Data Source
      KAKENHI-PROJECT-24248022

  • [Presentation] 理研天然化合物バンクNPDepoの構築と活用2014
    • Author(s)
      長田裕之
    • Organizer
      文科省新学術領域研究・がん支援「化学療法基盤支援活動」第三回シンポジウムアカデミアからの抗がん剤創薬に向けて-天然物の有効利用
    • Place of Presentation
      万国津梁館(沖縄県・名護市)
    • Year and Date
      2014-05-12
    • Data Source
      KAKENHI-PROJECT-221S0001

  • [Presentation] High-throughput screening of cell cycle inhibitors from NPDepo library2014
    • Author(s)
      Hiroyuki Osada
    • Organizer
      Korean Society for Biochemistry and Molecular Biology (KSBMB): Annual International Conference 2014
    • Place of Presentation
      COEX Center (Seoul, Korea)
    • Year and Date
      2014-05-16
    • Invited
    • Data Source
      KAKENHI-PROJECT-24248022

  • [Presentation] 世界における天然物創薬の現状2014
    • Author(s)
      長田 裕之
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学 生田キャンパス（神奈川県）
    • Invited
    • Data Source
      KAKENHI-PROJECT-24248022

  • [Presentation] Chemical biology for anticancer agents(抗がん剤のケミカルバイオロジー)2013
    • Author(s)
      長田裕之
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-221S0001

  • [Presentation] 糸状菌由来新規抗がん活性物質pyrrolizilactoneの標的同定2013
    • Author(s)
      川谷 誠, 青野 晴美, 野川 俊彦, 二村 友史, 室井 誠, 渡辺 信元, 長田 裕之
    • Organizer
      第17回日本がん分子標的治療学会学術集会