HIGASHIHARA Masaaki 東原正明

… Alternative Names

東原正明ヒカ゛シハラマサアキ

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Researcher Number	80165084
Other IDs
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Affiliation (based on the past Project Information) *help	2012 – 2014: 北里大学, 医学部, 教授 2000 – 2010: 北里大学, 医学部, 教授 1997 – 1998: 北里大学, 医学部, 教授 1996: 東京大学, 医学部・附属病院, 講師 1995 – 1996: 東京大学, 医学部(病), 講師 … More 1992 – 1994: 東京大学, 医学部(病), 助手 1992: 東京大学, 医学部(病)第一内科, 助手 1991: 東京大学, 医学部・(病), 助手 1989: 東京大学, 医学部, 医員 Less
Review Section/Research Field	Principal Investigator Hematology / Hematology Except Principal Investigator Human pathology / Human pathology / 内科学一般 / Laboratory medicine
Keywords	Principal Investigator myosin / ミオシン / 血小板 / クローニング / myosin I / リン酸化 / ミオシン軽鎖 / 血液細胞 / アイソフォーム / ミオシン重鎖 … More / platelet / cloning / cDNA / 細胞骨格蛋白 / モノクロナル抗体 / モノクローナル抗体 / isoform / 単球 / 非古典的ミオシン / サイトカイン / 巨核球 / mutant / MYH-9 / proplatelet / may-Hegglin anomaly / myosin sunerfamily / バキュロウイルス / rho-kinase / rho / GFP / 軽鎖 / 遺伝子異常 / 遺伝子変異 / unconventional myosin / lymphocyte / myosin light chain / myosin heavy chain / library / sequence / cord blood / 網血小板 / mpl / ライブラリー / シークエンス / 臍帯血 / Dephosphorylation / Phosphorylation / Myosin / Cytoskeletal protein / Growth / Differentiation / Hematopoietic stem cells / ビメンチン / 細胞分裂 / 白血病細胞 / 脱リン酸化 / 増殖 / 分化 / 造血幹細胞 / monoclonal antibody / phosphatase / phosphorylation / Stroma cells / フォスファターゼ / 骨髄幹細胞 / 脱リン酸化酵素 / ストローマ細胞 / Golgi complex / ミオシン・スーパーファミリー / Jurkat細胞 / 多発性骨髄腫 / 白血病細胞株 / myosin X / myosin VI / myosinVI / MYH9 異常症 / mRNA / IL6 / ヌ-ドマウス / インターロイキン-6 / 悪性中皮腫 / 造血因子 … More Except Principal Investigator JunB / NF-κB / NPM-ALK / Hodgkinリンパ腫 / CD30 / P80 / 未分化大細胞型リンパ腫 / Hodgkin lymphoma / CD30 promoter / NF-kB / 未分化大細胞性リンパ腫 / anaplastic large cell lymphoma / ALCL / Nf-kB / Hogkinリンパ腫 / Hodgkin and Reed-Sternberg cells / Hodgkin's lymphoma / signalosome / IKK / NIK / TRAF / IL-13 / Hodgkin、Reed-Sternberg細胞 / Hodgkin、Reed-sternberg細胞 / Fibroblasts / Vascular smooth muscle cells / Megakaryocytes / GTP-binding protein / Receptor / Platelet-activating factor / Thoromboxane / Prostaglandin / 血管平滑筋 / 糸球体メサンギウム細胞 / 巨核芽細胞 / 線維芽細胞 / 血管平滑筋細胞 / 巨核芽 / GTP結合蛋白質 / 受容体 / 血小板活性化因子 / トロンボキサン / プロスタグランジン / 細胞骨格蛋白質 / proplatelet / 細胞内膜輸送 / 非筋ミオシン / 細胞骨格 / 血小板 / Hodkinリンパ腫 / NPM-Alk / ポジキンリンパ腫 / Ets-1 / トロンボキサンA_2 / 単クロ-ン抗体 / アラキドン酸遊離 / 抗CD9抗体 / 血小板活性化 Less

Clarification of molecular pathogenesis of hematological diseases by analyzing functional role of myosin superfamily
- Principal Investigator
  
  MIYAZAKI Koji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kitasato University
Molecular mechanisms of Hodgkin and anaplastic large cell lymhoma triggered by CD30 induction and P80
- Principal Investigator
  
  HORIE Ryouichi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
Pathological analyses of myosin superfamily disordersPrincipal Investigator
- Principal Investigator
  
  HIGASHIHARA Masaaki
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kitasato University
Analysis of molecular basis for occurance of Hodgkin lympnoma and anaplastic large cell lymphoma
- Principal Investigator
  
  HORIE Ryouichi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
Analyses of phenotypic changes of Hodgkin and Reed-Stemberg cells to anaplastic large cell lymphoma cells by p80.
- Principal Investigator
  
  HORIE Ryouichi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  KITASATO UNIVERSITY
Functional analysis of myosin superfamily in blood cellsPrincipal Investigator
- Principal Investigator
  
  HIGASHIHARA Masaaki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kitasato University
Analyses of molecular bases of Hodgkin lymphoma by CD30-NF-kB pathway.
- Principal Investigator
  
  HORIE Ryouichi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  KITASATO UNIVERSITY
Analysis of expression and function of myosins in hematological cellsPrincipal Investigator
- Principal Investigator
  
  HIGASHIHARA Masaaki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kitasato University
Genetic and functional analysis of myosin I of blood cellsPrincipal Investigator
- Principal Investigator
  
  HIGASHIHARA Masaaki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  KITASATO UNIVERSITY
Functional analysis of phosphorylation/dephosphorylation of cytoskeletal proteins in differentiation and growth of hematopoieic stem cell.Principal Investigator
- Principal Investigator
  
  HIGASHIHARA Masaaki
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  1st Department of Internal Medicine, Faculy of Medicine University of Thokyo.
Functional role and its analysis of cytoslkeletal proteins in stroma cells and in hematopoetic stem cells.Principal Investigator
- Principal Investigator
  
  HIGASHIHARA Masaaki
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  1st Department of Internal Medicine, Faculy of Medicine, University of Tkyo
Cellular and molecular biological study on the pathophysiological roles of receptors for lipid mediators on atharosclerosis
- Principal Investigator
  
  WATANABE Tsuyoshi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  University of Tokyo
癌細胞株からの血小板増加因子の分離と解析Principal Investigator
- Principal Investigator
  
  東原正明
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
血小板CD9の抗原の構造と機能の解明
- Principal Investigator
  
  久米章司
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  山梨医科大学

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All Journal Article Presentation

[Journal Article] Acute leukemia during pregnancy: an investigative survey of the past 11 years.2015
- Author(s)
  Nakajima Y1, Hattori Y, Ito S, Ohshima R, Kuwabara H, Machida S, Shirasugi Y, Miyazaki K, Sakai R, Tomita N, Ando K, Higashihara M, Ishigatsubo Y, Fujisawa S.
- Journal Title
  
  Int J Lab Hematol.
  
  Volume: 37(2) Issue: 2 Pages: 174-180
- DOI
  10.1111/ijlh.12256
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590703
[Journal Article] Lenalidomide-induced acute lung injury in case of multiple myeloma.2013
- Author(s)
  Danbara, M., Tadera, N., Togano, T., Katayama, T., Aoki, T., Miyazaki, K., Higashihara, M.
- Journal Title
  
  Int. J. Clin. Pharmacol. Ther
  
  Volume: 51(6) Issue: 06 Pages: 513-516
- DOI
  10.5414/cp201840
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590703
[Journal Article] Fcγ receptor IIB gene polymorphism in adult Japanese patients with primary immune thrombocytopenia.2013
- Author(s)
  Satoh T1, Miyazaki K, Shimohira A, Amano N, Okazaki Y, Nishimoto T, Akahoshi T, Munekata S, Kanoh Y, Ikeda Y, Higashihara M, Takahashi S, Kuwana M.
- Journal Title
  
  Blood
  
  Volume: Sep 12;122 Issue: 11 Pages: 1991-2
- DOI
  10.1182/blood-2013-05-501858
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590687, KAKENHI-PROJECT-24590703
[Journal Article] Surface CD3 expression proceeds through both myosin regulatory light chain9 (MYL9)-dependent and MYL9-independent pathways in Jurkat cells.2012
- Author(s)
  Aoki T, Miyazaki K, Katayama T, Watanabe M, Horie R, Danbara M, Higashihara M.
- Journal Title
  
  Journal of Smooth Muscle Research
  
  Volume: 48 Pages: 137-147
- NAID
  10031151480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590703
[Journal Article] A case of giardiasis expressing severe systemic symptoms and marked, hypereosinophilia.2010
- Author(s)
  Suzuki Y, Nakamura T, Tokoro M, Togano T, Ohsaka M, Kohri M, Hirata Y, Miyazaki K, Danbara M, Horie R, Miura I, Sunakawa K, Higashihara M.
- Journal Title
  
  Parasitol Int. 59
  
  Pages: 487-489
- NAID
  10029825838
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590374
[Journal Article] The side population, as a precursor of Hodgkin and Reed-Sternberg cells and a target for nuclear factor-kappaB inhibitors in Hodgkin's lymphoma.2010
- Author(s)
  Nakashima M, Ishii Y, Watanabe M, Togano T, Umezawa K, Higashihara M, Watanabe T, Horie R.
- Journal Title
  
  Cancer Sci. 101
  
  Pages: 2490-2496
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590374
[Journal Article] Constitutive activity of nuclear transcription factor kappaB is observed in follicular lymphoma.2010
- Author(s)
  Suzuki Y, Yoshida T, Horie R, Tsuruta T, Togano T, Ohsaka M, Miyazaki K, Danbara M, Ohtani S, Okayasu I, Higashihara M.
- Journal Title
  
  J Clin Exp Hematop. 50
  
  Pages: 45-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590374
[Journal Article] CD3- and CD4-positive plasmablastic lymphoma: a literature review of JapanesePlasmablastic, lymphoma cases.2010
- Author(s)
  Suzuki Y, Yoshida T, Nakamura N, Kamata H, Kotani S, Ohsaka M, Kajita S, Miyazaki K, Ohtani S, Nakayama M, Horie R, Hayakawa K, Niitsu N, Higashihara M.
- Journal Title
  
  Intern Med. 49
  
  Pages: 1801-1805
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590374
[Journal Article] Induction of oncogene addiction shift to NF-kB by camptothecin in solid tumor cells.2009
- Author(s)
  Togano T, Sasaki M, Watanabe M, Makoto Nakashima M, Tsuruo T, Umezawa K, Higashihara M, Toshiki Watanabe T, Horie R.
- Journal Title
  
  Biochem Biophys Res Commun. 390
  
  Pages: 60-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590374
[Journal Article] Lymphoproliferative disorders after immunosuppressive therapy for aplastic anemia: a case report and literature review.2009
- Author(s)
  Suzuki Y, Niitsu N, Hayama M, Katayama T, Ishii R, Osaka M, Miyazaki K, Danbara M, Horie R, Yoshida T, Nakamura N, Higashihara M.
- Journal Title
  
  Acta Haematol. 121
  
  Pages: 21-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590374
[Journal Article] CD20-positive T-cell large granular lymphocyte leukemia: case report and review of the literature.2009
- Author(s)
  Miyazaki K, Ohsaka M, Suzuki Y, Danbara M, Horie R, Higashihara M.
- Journal Title
  
  Intern Med. 48
  
  Pages: 1443-1447
- NAID
  130000122030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590374
[Journal Article] Smooth Muscle type isoform of 20 kDa myosin light chain is expressed in monocyte/macrophage cell lineage2008
- Author(s)
  Higashihara M, Watanabe M, Usuda S, Miyazaki K
- Journal Title
  
  Journal of Smooth Muscle Research 44
  
  Pages: 29-40
- NAID
  110006664781
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591087
[Journal Article] Smooth Muscle type isoform of 20 kDa myosin light chain is expressed in monocyte/macrophage cell lineage2008
- Author(s)
  Higashihara M, et al.
- Journal Title
  
  Journal of Smooth Muscle Research 44
  
  Pages: 29-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591087
[Journal Article] Smooth muscle type isofom of 20 kD amyosin lhght chain is expressed in monocyte/macrophage cell lineage2008
- Author(s)
  Higashihara M, et. al.
- Journal Title
  
  J Smooth Muscle Res (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591087
[Journal Article] Hypomethylation of CD30 CpG islands with aberrant JunB expression drives CD30 induction in Hodgkin lymphoma and anaplastic large cell lymphoma.2008
- Author(s)
  Watanabe M, Ogawa Y, Itoh K, Koiwa T, Kadin ME, Watanabe T, Okayasu I, Higashihara M, Horie R.
- Journal Title
  
  Lab Invest. 88
  
  Pages: 48-57
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590374
[Journal Article] Identification of the RelA domain responsible for action of a new NF-kappaB inhibitor DHMEQ.2008
- Author(s)
  Watanabe M, Nakashima M, Togano T, Higashihara M, Watanabe T, Umezawa K, Horie R.
- Journal Title
  
  Biochem Biophys Res Commun. 376
  
  Pages: 310-314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590374
[Journal Article] IkBalpa independent induction of NF-kappaB and its inhibition b DHMEQ in Hodgkin-Reed-Sternberg cells2007
- Author(s)
  Watanabe, M, Dewan, MZ, Taira, M, Shoda, M, Honda, M, Sata, T, Higashihara, M, Kadin, ME, Watanabe, T, Yamamoto, N, Umezawa, K, Horie, R
- Journal Title
  
  Lab Invest 87
  
  Pages: 372-82
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590345
[Journal Article] TRAF activation of C/EBPb (NF-IL6) via p38 MAPK induces HIV-1 gene expression in monocytes/macrophages2007
- Author(s)
  Horie, R, Ishida, T, Maruyama-Nagai, M, Ito, K, Watanabe, M, Yoneyama, A, Higashihara, M, Kimura, S, Watanabe, T
- Journal Title
  
  Microbes Infect 48
  
  Pages: 721-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590345
[Journal Article] DHMEQ, a new NF-kappaB inhibitor, induces apoptosis and enhances fludarabine effects on chronic lymphocytic leukemia cells2006
- Author(s)
  Horie, R, Watanabe, M, Okamura, T, Taira, M, Shoda, M, Motoji, T, Utsunomiya, A, Watanabe, T, Higashihara, M, Umezawa, K
- Journal Title
  
  Leukemia 20
  
  Pages: 800-806
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590345
[Journal Article] JunB induced by constitutive CD30-extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase signaling activates the CD30 promoter in anaplastic large cell lymphoma and reed-sternberg cells of Hodgkin lymphoma.2005
- Author(s)
  Watanabe M, Sasaki M, Itoh K, Higashihara M, Umezawa K, Kadin ME, Abraham LJ, Watanabe T, Horie R.
- Journal Title
  
  Cancer Res. 65
  
  Pages: 7628-7634
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590294
[Journal Article] Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ, a potent and selective inhibitor of NF-{kappa}B, as a strategy for chemoprevention and therapy of adult T-cell leukemia.2005
- Author(s)
  Watanabe M, Ohsugi T, Shoda M, Ishida T, Aizawa S, Maruyama-Nagai M, Utsunomiya A, Koga S, Yamada Y, Kamihira S, Okayama A, Kikuchi H, Uozumi K, Yamaguchi K, Higashihara M, Umezawa K, Watanabe T, Horie R.
- Journal Title
  
  Blood 106
  
  Pages: 2462-2471
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590294
[Journal Article] A novel NF-kB inhibitor DHMEQ selectively targets constitutive NF-kB activity and induces apoptosis of multiple myeloma cells in vitro and in vivo.2005
- Author(s)
  Watanabe M, Dewan MZ, Okamura T, Sasaki M, Itoh K, Higashihara M, Mizoguchi H, Honda M, Sata T, Watanabe T, Yamamoto N, Umezawa K, Horie R.
- Journal Title
  
  Int J Cancer. 114
  
  Pages: 32-38
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590294
[Journal Article] The NPM-ALK oncoprotein abrogates CD30 signaling and constitutive NF-kB activation in anaplastic large cell lymphoma.2004
- Author(s)
  Horie R, Watanabe M, Ishida T, Koiwa T, Aizawa S, Ito K, Higashihara M, Kadin E, Watanabe T
- Journal Title
  
  Cancer Cell 5
  
  Pages: 353-364
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590294
[Journal Article] Identification of three in-flame deletion mutations in MYH9 disorders suggesting an important hot spot for small rearrangements on MYH9 exon 24
- Author(s)
  Miyazaki K, Kunishima K, Higashihara M
- Journal Title
  
  European Journal of Haematology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591087
[Presentation] Detection of Anti-Thrombopoietin Antibodies in Patients with Immune Thrombocytopenia2014
- Author(s)
  Satoh T, Miyazaki K, Shimada N, Nagane K, Inukai T, Nakajima H, Higashihara M, Takahashi S.
- Organizer
  米国血液学会
- Place of Presentation
  サンフランシスコ（アメリカ合衆国）
- Year and Date
  2014-12-08
- Data Source
  KAKENHI-PROJECT-24590703
[Presentation] Affect of aberrant T cell antigenexpression on DLBCL patients'background and prognosis.2010
- Author(s)
  Suzuki Y.,(13名)Horie R, Higashihara M
- Organizer
  第72回日本血液学会総会
- Place of Presentation
  横浜
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-20590374
[Presentation] Affect of aberrant T cell antigen expewssion on DLBCL patients'backgrownd and prognosis2010
- Author(s)
  Suzuki Y(13名)Horie R, Higashihara M
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-20590374
[Presentation] Identification of the RelA domainresponsible for the action of a newNF-kB inhibitor DHMEQ2009
- Author(s)
  RyouichiHorie, (3名)Masaaki Higashihara, Toshiki Watanabe, Kazuo Umezawa
- Organizer
  第71回日本血液学会学術総会
- Place of Presentation
  京都
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20590374
[Presentation] MyosinVIの血液細胞における発現と局在の検討2008
- Author(s)
  臼田茂樹、宮崎浩二、川上速人、東原正明
- Organizer
  第50回日本平滑筋学会
- Place of Presentation
  弘前
- Data Source
  KAKENHI-PROJECT-18591087
[Presentation] CD30プロモーターメチル化とJunBを介したCD30誘導機構の解析2008
- Author(s)
  堀江良一、(7名)東原正明
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-20590374
[Presentation] MyosinVIの白血病細胞株における発現と局在の検討2008
- Author(s)
  東原正明, 他
- Organizer
  日本平滑筋学会
- Place of Presentation
  弘前市
- Year and Date
  2008-07-04
- Data Source
  KAKENHI-PROJECT-18591087
[Presentation] MyosinVIの白血病細胞株における発現と局在の検討2008
- Author(s)
  青木克己, 東原正明, 他
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都府
- Year and Date
  2008-10-12
- Data Source
  KAKENHI-PROJECT-18591087
[Presentation] Myosin VI の血液細胞における発現と局在の検討2008
- Author(s)
  青木卓巳、臼田茂樹、宮崎浩二、東原正明
- Organizer
  第70 回日本血液学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18591087
[Presentation] Localization and expression of myosin VI in human haematopoietic cells including platelets2007
- Author(s)
  Higashihara M, Usuda S, Miyazaki K, Watanabe M, Mohri H, Kawakami H.
- Organizer
  XX1st Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Switzerland
- Data Source
  KAKENHI-PROJECT-18591087
[Presentation] MyosinVIの血液細胞における発現と局在の検討2007
- Author(s)
  臼田茂樹、宮崎浩二、川上速人、東原正明
- Organizer
  第49回日本平滑筋学会
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-18591087
[Presentation] MyosinVIの血液細胞における発現と局在の検討2007
- Author(s)
  臼田茂樹、東原正明, 他
- Organizer
  第49回日本平滑筋学会
- Place of Presentation
  奈良市
- Data Source
  KAKENHI-PROJECT-18591087
[Presentation] ヒト血液細胞におけるミオシン・スーパーファミリー分子の発現動態の検討2006
- Author(s)
  臼田茂樹、宮崎浩二、東原正明、池辺光男
- Organizer
  第48 回日本平滑筋学会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-18591087
[Presentation] Tail Mutation of MYH9 inhibits the disassembly of non-muscle myosin IIA
- Author(s)
  Miyazaki K, Komatsu S, Jung HS, Higashihara M, Craig R, Ikebe M.
- Organizer
  欧州血液学会
- Place of Presentation
  ウイーン（オーストリア）
- Year and Date
  2015-06-11 – 2015-06-14
- Data Source
  KAKENHI-PROJECT-24590703

1. HORIE Ryouichi (80229228)

# of Collaborated Projects: 8 results

# of Collaborated Products: 20 results
2. MIYAZAKI Kouji (90261966)

# of Collaborated Projects: 4 results

# of Collaborated Products: 12 results
3. WATANABE Toshiki (30182934)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. DANBARA Mikio (80255348)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YONEYAMA Akiko (50175684)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. AKIYAMA Nobu (50286358)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. TAKAISHI Masaaki (10256307)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 須永真司 (70282621)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. WATANABE Tsuyoshi (80158641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TSUKAMOTO Kazuhisa (20251233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NAKAO Akihide (10159056)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HASHIMOTO Yoshiaki (40172879)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SHIMIZU Takao (80127092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. WATABE Shugo (40111489)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KANEKO Takako (00286361)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KAMATA Kouju (20146343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. NIITSU Nozomi (20256697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 久米章司 (50010492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 尾崎由基男 (30134539)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 矢富裕 (60200523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 青木克已 (40291322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. IKEBE Mitsuo

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. MIURA Noboru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. INAGAKI Masaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. TSUJINO Shiho

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. AOKI Katsunori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 小山真理子

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. SATOH Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 渡辺俊樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
30. 高橋伸一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIGASHIHARA Masaaki 東原 正明

東原 正明 ヒカ゛シハラ マサアキ

Research Projects

Research Products

Co-Researchers

Clarification of molecular pathogenesis of hematological diseases by analyzing functional role of myosin superfamily

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Molecular mechanisms of Hodgkin and anaplastic large cell lymhoma triggered by CD30 induction and P80

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Pathological analyses of myosin superfamily disordersPrincipal Investigator

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Analysis of molecular basis for occurance of Hodgkin lympnoma and anaplastic large cell lymphoma

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Analyses of phenotypic changes of Hodgkin and Reed-Stemberg cells to anaplastic large cell lymphoma cells by p80.

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Functional analysis of myosin superfamily in blood cellsPrincipal Investigator

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Analyses of molecular bases of Hodgkin lymphoma by CD30-NF-kB pathway.

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Analysis of expression and function of myosins in hematological cellsPrincipal Investigator

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Genetic and functional analysis of myosin I of blood cellsPrincipal Investigator

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Functional analysis of phosphorylation/dephosphorylation of cytoskeletal proteins in differentiation and growth of hematopoieic stem cell.Principal Investigator

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Functional role and its analysis of cytoslkeletal proteins in stroma cells and in hematopoetic stem cells.Principal Investigator

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Cellular and molecular biological study on the pathophysiological roles of receptors for lipid mediators on atharosclerosis

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癌細胞株からの血小板増加因子の分離と解析Principal Investigator

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HIGASHIHARA Masaaki 東原正明

東原正明ヒカ゛シハラマサアキ