SHIRAI Ryuichi 白井隆一

… Alternative Names

Researcher Number	80183838
Other IDs
External Links
Affiliation (Current)	2022: 同志社女子大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2006 – 2008: 同志社女子大学, 薬学部, 教授 1999 – 2004: 奈良先端科学技術大学院大学, 物質科学教育研究センター, 助教授 1999: 奈良先端大学, 大学院・物質科学教育研究センター, 助教授 1993 – 1998: 東京大学, 分子細胞生物学研究所, 助手 1993: 東大, 分子細胞生物学研究所, 助手 1990: Kitasato Univ., Pharm. Sci., Assistant 1988: 北里大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Chemical pharmacy / 医薬分子機能学 / Chemical pharmacy Except Principal Investigator Chemical pharmacy / 医薬分子機能学
Keywords	Principal Investigator 不斉合成 / 全合成 / チューブリン / 有糸分裂阻害剤 / 構造活性相関 / キュラシンA / 微小管 / dysidiolide / cdc25A / 立体選択的合成 … More Except Principal Investigator チューブリン / 分子認識 / 分子設計 / 微小管機能制御物質 / 情報伝達 / ウスチロキシン / 有糸分裂阻害剤 / キュラシンA / tubulin / レチノイド / フタルイミド / サリドマイド / 医薬品化学 / thalidomide / molecular design / KDN / アザコンブレタスタチン / 新規抗がん剤 / リン脂質 / ホシファテシジルイノシトールキナーゼ / 組織応答 / 分化 / アダプター / イノシトールリン脂質 / MAPキナーゼ / ホスホリパーゼ / がん / キナーゼ / Gタンパク質 / 細胞応答 / 発癌 / 転移 / 微小管機能 / 分子機能 / アザコンプレタスタチン / キュラシン / 分子確認 / リゾキシン / フォモプシン / microtubules / molecular recognition / ustiloxin / aza-combretastatin / curacin / デキストラン / インターカレーター / ポルフィリン / アフィニティーラベル / 核酸 / 受容体 / 発癌プロモーター / インターカレーション / ジヌクレオチド / 塩基選択性 / 水溶性ポリマー / ヘミン / dextran / intercalator / retinoid / porphyrin / affinity labeling / nucleic acid / receptor / tumor promoter / 腫瘍壊死因子 / サイトカイン / 細胞種 / 生物学的応答調節剤 / 光学活性依存性 / 2方向性調節 / 光学異性体 / 生物応答調節剤 / tumor necrosis factor / phthalimide / cytokine / cell type / bidirectional regulation / enantio-dependence / biological response modifier / 作用機作 / アレナスタチンA / antimitotic agent / action mechanism / ustiloxins / curacin A / arenastatin A / ホスファチジルイノシトール / ホスファチジルイノシトール3-キナーゼ / 負イオンFAB MS / マトリックス / ホスファチジルイノシトール3-リン酸 / ホスファチジルイノシトール 3-キナーゼ / 負イオンFABMS / ホスファチジルイノシトール 3-リン酸 / 脂肪酸側鎖 / PI3キナーゼ / PI3 5-ホスファターゼ / 質量分析 / phosphatidylinositol / phosphatidylinositol 3-kinase / matrix / FAB MS / phosphatidylinositol 3-phosphate / 核内レセプター / アンドロゲン / 構造展開 / 酵素阻害剤 / リガンド / 構造活性相関 / ヘシン / アンドロジェン / アンタゴニスト / ホモフタルイミド / シナージスト / 阻害剤 / 情報伝達物質 / nuclear receptor / retioids / androgen / structural development / enzyme inhibitors / ligand / 触媒的不斉脱プロトン化 / 触媒的不斉アルキル化 / 触媒的不斉プロトン化 / 四座配位子型キラルアミン / 二座配位子型アキラルアミン / リチウムエイラート / 不斉アルキル化 / 不斉アシル化 / 不斉三級炭素 / 不斉四級炭素 / 含フッ素不斉四級炭素 / リチウムエノラート / 配位子交換 / 反応加速 / Catalytic Asymmetric Deprotonation / Catalytic Asymmetric Alkylation / Catalytic Asymmetric Protonation / Tetradentate Chiral Amine / Bidentate Achiral Amine / Nーアセチルノイラミン酸 / シアル酸 / マイトマイシン / G_<M3>アナログ / グリコシド / 神経突起伸展 / N__ーーアセチルノイラミン酸 / Neu5Ac / 立体配置 / 神経細胞増生 / N-アセチルノイラミン酸 / N-アセチル-2,3-デヒドロ-2-デオキシノイラミン酸 / 1,7-ラクトン誘導体 / 3-デオキシ-D-ノヌロン酸 / X線解析 / 立体化学 / N-acetylneuraminic acid / glycosylation / stereochemistry / Koenigs-Knorr Less

Total synthesis of Salinosporamide A, a potent proteasome inhibitorPrincipal Investigator
- Principal Investigator
  
  SHIRAI Ryuichi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Doshisha Women's College of Liberal Arts
Synthetic study of novel inositol phosphoceramide CJP2Principal Investigator
- Principal Investigator
  
  SHIRAI Ryuichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  NARA INSTITUTE OF SCIENCE AND TECHNOLOGY
Total synthesis of phosphatidylinositol 3,5-bisphosphatePrincipal Investigator
- Principal Investigator
  
  SHIRAI Ryuichi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  NARA INSTITUTE OF SCIENCE AND TECHNOLOGY
Catalytic Asymmetric Alkylation and Protonation of Lithium Enolates
- Principal Investigator
  
  KOGA Kenji
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Nara Institute of Science and Technology
がんの発生、発達に関する情報伝達の解析
- Principal Investigator
  
  福井泰久
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
Structural development of bio-active compounds affecting nuclear receptor function
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokyo
Asymmetric synthesis of proteinphosphatase inhibitor dysidiolode and its potent analogsPrincipal Investigator
- Principal Investigator
  
  SHIRAI Ryuichi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  NARA INSTITUTE OF SCIENCE AND TECHNOLOGY
  The University of Tokyo
Mass spectrometry of phosphatidylinositols with various fatty acid side chain
- Principal Investigator
  
  MORISAKI Naoko
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The Universityu of Tokyo
STUDIES ON THE ANTIMITOTIC AGENTS-TUBULIN INTERACTION AND DRUG DESIGN
- Principal Investigator
  
  IWASAKI Shigeo
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  INSTITUTE OF MOLECULAR AND CELLULAR BIOSCIENCES,THE UNIVERSITY OF TOKYO
SYNTHESIS OF ANTIMITOTIC NATURAL PRODUCTSPrincipal Investigator
- Principal Investigator
  
  SHIRAI Ryuichi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  UNIVERSITY OF TOKYO
有糸分裂阻害剤キュラシンAの不斉全合成Principal Investigator
- Principal Investigator
  
  白井隆一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokyo
Development of Phthalimide-type Novel Tumor Necrosis Factor (TNF) Production-regulators
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  THE UNIVERSITY OF TOKYO
フォモプシン、ウスチロキシンをリ-ド化合物とする新規有糸分裂阻害剤の設計と合成Principal Investigator
- Principal Investigator
  
  白井隆一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokyo
Preparation of Functional Polylipid Biofactors
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  THE UNIVERSITY OF TOKYO
リガンド分子設計によるチューブリンの薬物認識機構の解析
- Principal Investigator
  
  IWASAKI Shigeo
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
ダイネミシン型アミノアントラキノン類の合成およびDNAとの相互作用の研究Principal Investigator
- Principal Investigator
  
  白井隆一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokyo
Regulators of Microtubule Assembly : Molecular Recognition Mechanism and Developement of New Regulators.
- Principal Investigator
  
  IWASAKI Shigeo
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Institute of Molecular and Cellular Biosciences The University of Tokyo
Stereochemical Studies on Sialic Acid Derivatives
- Principal Investigator
  
  OGURA Haruo
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University

All 2009 2008 2007

All Journal Article Presentation

[Journal Article] Palladium-Catalyzed 1,2-Addition of Potassium Aryl- and Alkenyltrifluoro borates to Aldehydes using Thioether-Imidazolinium Carbene Ligands2008
- Author(s)
  Masami Kuriyama, Rumiko Shimazawa, Terumichi Enomoto, Ryuichi Shirai
- Journal Title
  
  Journal of Organic Chemistry 73
  
  Pages: 6939-6942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590023
[Journal Article] Direct asymmetric aldol reactions catalyzed by lproline-2,4,6-trinitroanilide2008
- Author(s)
  Kosuke Sato, Masami Kuriyama, Rumiko Shimazawa, Tsumoru Morimoto, Kiyomi Kakiuchi, Ryuichi Shirai
- Journal Title
  
  Tetrahedron Letters 49
  
  Pages: 2402-2406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590023
[Journal Article] Anacid-catalyzed ring-switch reaction of lactums to lactones : concise synthesis of 2,4-dialkyl-3-hydroxybutanolides2008
- Author(s)
  Chiaki Yamauchi, Masami Kuriyama, Rumiko Shimazawa, Tsumoru Morimoto, Kiyomi Kakiuchi, Ryuichi Shirai
- Journal Title
  
  Tetrahedron 64
  
  Pages: 3133-3140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590023
[Journal Article] Design and Synthesis of Novel C2-Symmetric Chiral Piperadines and an Application to Asymmetric Acylation of σ-Symmetric 1,2-Diols2008
- Author(s)
  Daisuke Nakamura, Kiyomi Kakiuchi, Kenji Koga, Ryuichi Shirai
- Journal Title
  
  Organic Letters 8
  
  Pages: 6139-6142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590023
[Journal Article] Efficient 1,2-Addition of Aryl- and Alkenylboronic Acids to Aldehydes Catalyzed by the Palladium/Thioether-Imidazolinium Chloride System2008
- Author(s)
  Masami Kuriyama, Rumiko Shimazawa, Ryuichi Shirai
- Journal Title
  
  Journal of Organic Chemistry 73
  
  Pages: 1597-1600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590023
[Presentation] C-S二座配位子-パラジウム触媒による有機ホウ酸試薬のキラルアルデヒドへのジアステレオ選択的1,2-付加反応2009
- Author(s)
  榎本光伯, 栗山正巳, 白井隆一
- Organizer
  日本薬学会129年会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-18590023
[Presentation] C-S二座配位子-パラジウム触媒による有機ホウ酸試薬のキラルアルデヒドへのジアステレオ選択的1,2-付加反応2008
- Author(s)
  榎本光伯, 栗山正巳, 白井隆一
- Organizer
  第58回日本薬学会近畿支部総会・大会
- Place of Presentation
  神戸薬科大学
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-18590023
[Presentation] 複素環カルベンを基盤とするC-S二座配位子-パラジウム触媒による有機ホウ素試薬を用いたアルデヒドへの付加反応2008
- Author(s)
  栗山正巳, 嶋澤るみ子, 白井隆一
- Organizer
  日本薬学会128年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-18590023
[Presentation] C-S二座配位子-パラジウム触媒を用いた有機三フッ化ホウ素塩のアルデヒドへの付加反応2008
- Author(s)
  栗山正巳, 嶋澤るみ子, 榎本光伯, 白井隆一
- Place of Presentation
  神戸薬科大学
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-18590023
[Presentation] C-S二座配位子-パラジウム触媒を用いた有機三フッ化ホウ素塩のアルデヒドへの付加反応2008
- Author(s)
  栗山正巳, 石山夏希, 榎本光伯, 嶋澤るみ子, 白井隆一, 尾野村治
- Organizer
  反応と合成の進歩シンポジウム
- Place of Presentation
  京都テルサ
- Year and Date
  2008-11-04
- Data Source
  KAKENHI-PROJECT-18590023
[Presentation] 複素環カルベンを基盤とするC-S二座配位子-パラジウム触媒による有機ホウ素試薬を用いたアルデヒドへの付加反応2007
- Author(s)
  栗山正巳, 嶋澤るみ子, 白井隆一
- Organizer
  第57回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪薬科大学
- Year and Date
  2007-10-27
- Data Source
  KAKENHI-PROJECT-18590023

1. IWASAKI Shigeo (00013326)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. HASHIMOTO Yuichi (90164798)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. MORISAKI Naoko (00092354)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. SHIMAZAWA Rumiko (00411083)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. KURIYAMA Masami (40411087)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
6. KOBAYASHI Hisayoshi (80225531)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KOISO Yuikiko (50092200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KOGA Kenji (10012600)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OGURA Haruo (90050335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAMASAKI Toshiko (60230380)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KAI Toshitugu (30224322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. FURUHATA Kimio (60050605)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKAYANAGI Hiroaki (00050477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TAKEDA Kazuyoshi (10050684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 福井泰久 (00181248)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 黒崎知博 (50178125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 稲垣昌樹 (30183007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 一條秀憲 (00242206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 田村真理 (20124604)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SHIRAI Ryuichi 白井 隆一

SIRAI Ryuiti

白井 隆一

Research Projects

Research Products

Co-Researchers

Total synthesis of Salinosporamide A, a potent proteasome inhibitorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Synthetic study of novel inositol phosphoceramide CJP2Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Total synthesis of phosphatidylinositol 3,5-bisphosphatePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Asymmetric synthesis of proteinphosphatase inhibitor dysidiolode and its potent analogsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

SYNTHESIS OF ANTIMITOTIC NATURAL PRODUCTSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

有糸分裂阻害剤キュラシンAの不斉全合成Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

フォモプシン、ウスチロキシンをリ-ド化合物とする新規有糸分裂阻害剤の設計と合成Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

SHIRAI Ryuichi 白井隆一

白井隆一