OKAGAKI Tsuyoshi 岡垣壮

Researcher Number	80185412
Other IDs
Affiliation (based on the past Project Information) *help	2012 – 2013: 三重大学, 生物資源学研究科, 教授 2010 – 2011: 三重大学, 大学院・生物資源学研究科, 教授 2009: 三重大学, 大学院・生物資源学科, 教授 2008: 三重大学, 大学院・生物資源学研究科, 教授 2007: 三重大学, 生物資源学研究科, 教授 … More 2006: Mie University, Graduate School of Bioresouces, Assistant Professor, 大学院生物資源学研究科, 助教授 2006: 三重大学, 大学院生物資源学部, 助教授 2003 – 2005: 三重大学, 生物資源学部, 助教授 2000 – 2001: 三重大学, 生物資源学部, 助教授 1994 – 1999: 群馬大学, 医学部, 講師 1994: 群馬大学, 医学部・薬理学講座, 助手 Less
Review Section/Research Field	Principal Investigator General pharmacology / Cell biology / General medical chemistry / General pharmacology Except Principal Investigator 応用薬理学・医療系薬学 / General pharmacology / Cell biology / General pharmacology
Keywords	Principal Investigator ミオシン / 血管 / 形質変換 / 動脈硬化症 / 血管平滑筋 / 平滑筋 / atherosclerosis / myosin / ミオシン線維 / 蛋白質 … More / 細胞・組織 / 薬理学 / 細胞骨格 / S100 family / vascular smooth muscle cell / blood vessel / 合成型細胞 / 収縮型細胞 / サブトラクション / S100ファミリー / brain blood vessel / hypertension / cell, tissue / pharmacology / protein / 脳神経疾患 / 循環器・高血圧 / myosin filament / smooth muscle cell / vascular cell / タンパク質 / 遺伝子 / シグナル伝達 / 筋康線維 / リン酸化 / 分子生物学 / 細胞核 / 細胞周期 / カルシウム結合蛋白質 … More Except Principal Investigator ミオシン / ミオシン軽鎖キナーゼ / 平滑筋 / アクチン / myosin / recombinant protein / actin / myosin light chain kinase / smooth muscle / 収縮制御 / リン酸化 / 発現蛋白質 / カルシウムイオン / regulation / calcium / アクトミオシン / phosphorylation / 血管平滑筋 / cell motility / 遊走能 / 細胞運動 / Physarum / scallop / 結晶化 / 粘菌 / モーター・ドメイン / カルシウム結合 / calmodulin / カルモジュリン / アイチン / カルモジェリン / カルシウム・イオン / nerve cell / PC-12 Cell / Cytoskeleton / patch clamp / capsicin receptor / purinergic receptor / ATPase / 血管 / 創薬 / フォスファターゼ / スクリーニング / 創藥 / regulatory protein / regulation of contraction / antisence DNA / calcium ion / りん酸化 / 制御蛋白質 / アンチセンス / カルシウムイオン / プロテオミクス / 分化・脱分化 / 形質転換 / マクロRNA / 細胞遊走 / マイクロRNA / 脱分化 / 細胞分化 / PCR / 心筋 Less

Elucidation of cellular network for plastic change of vascular smooth muscle cell.Principal Investigator
- Principal Investigator
  
  OKAGAKI Tsuyoshi
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Mie University
Mechanism of transformation of vascular smooth muscle cell-MicroRNA as regulating factor
- Principal Investigator
  
  NAKAMURA Akio
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Gunma University
Screening of genes those are related to dynamic transition of myofiber of vascular smooth muscle cell upon phenotypic modulation.Principal Investigator
- Principal Investigator
  
  OKAGAKI Tsuyoshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Mie University
Analysis of stabilization and degradation mechanism of muscle fiber of vascular smooth muscle cell upon transformatioonPrincipal Investigator
- Principal Investigator
  
  OKAGAKI Tsuyoshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Mie University
Analysis of the function of myosin-stabilizing protein in living smooth muscle cellPrincipal Investigator
- Principal Investigator
  
  OKAGAKI Tsuyoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Mie University
Structure and function of Ca-sensitive myosins
- Principal Investigator
  
  KOHAMA Kazuhiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Cell biology
- Research Institution
  Gunma University, School of Medicine
Refulatory activity of myosin light chain kinase in smooth muscle cell
- Principal Investigator
  
  KOHAMA Kazuhiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Gunma University
心筋ミオシン軽鎖キナーゼのアクチン結合を介した新しい収縮制御様式の検討
- Principal Investigator
  
  小浜一弘
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Gunma University
平滑筋ミオシン結合蛋白質のミオシン線維形成と安定化における機能の解析Principal Investigator
- Principal Investigator
  
  岡垣壮
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Gunma University
Molecular approach to the structure and function of myosin light chain kinase
- Principal Investigator
  
  KOHAMA Kazuhiro
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Gunma University School of Medicine
平滑筋ミオシン線維を安定化させるミオシン結合蛋白の研究Principal Investigator
- Principal Investigator
  
  岡垣壮
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Gunma University
Screening for the smooth muscle relaxants
- Principal Investigator
  
  KOHAMA Kazuhiro
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Gunma University School of Medicine
多機能性カルシウム結合蛋白質:カルシウム抑制因子の構造と機能Principal Investigator
- Principal Investigator
  
  岡垣壮
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Gunma University
Physiological role of myosin light chain kinase in regulating smooth muscle contraction : An approach by gene targeting followed by rescue.
- Principal Investigator
  
  KOHAMA Kazuhiro
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Gunma University

All 2013 2011 2010 2008 2007 2005 Other

All Journal Article Presentation

[Journal Article] Thermal stability of carp actin in its polymerized form2011
- Author(s)
  Ooi, A., Okagaki, T.
- Journal Title
  
  Fish. Sci.
  
  Volume: 77 Pages: 1053-1059
- NAID
  10029654910
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590240
[Journal Article] 平滑筋ミオシンおよび調節タンパク質の精製法の改良2011
- Author(s)
  近藤哲也、鈴木亮、岡垣壮
- Journal Title
  
  三重大学生物資源学研究科紀要
  
  Volume: 37 Pages: 87-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590240
[Journal Article] 平滑筋からのmyosinおよび調節タンパク質の精製法の改良2011
- Author(s)
  近藤哲也、鈴木亮、岡垣壮
- Journal Title
  
  三重大学大学院生物資源学研究科紀要
  
  Volume: 第37号 Pages: 87-97
- NAID
  40018949003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590240
[Journal Article] Thermal stability of carp actin in its polymerized form2011
- Author(s)
  Ooi, A., Okagaki, T.
- Journal Title
  
  Fish.Sci.
  
  Volume: 77 Pages: 1053-1059
- NAID
  10029654910
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590240
[Journal Article] マダイミオシン加熱ゲル形成に及ぼすグルコン酸塩の影響2010
- Author(s)
  大井敦史、田村陽二郎、岡垣壮
- Journal Title
  
  日本水産学会誌
  
  Volume: 76 Pages: 1066-1072
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590240
[Journal Article] Blebbistatin inhibits the chemotaxis of vascular smooth muscle cells by disrupting the myosin II-actin interaction.2008
- Author(s)
  Wang HH, Tanaka H, Qin X, Z hao T, Ye LH, Okagaki T, Katayama T, Nakamura A, Ishikawa R, Thatcher SE, Wright GL, Kohama K.
- Journal Title
  
  Am J Physiol Heart Circ Physiol. 294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590240
[Journal Article] Role of non-kinase activity of myosin light- chain kinase in regulating smooth muscle contraction, a review dedicated to Dr. Setsuro Ebashi2008
- Author(s)
  Nakamura, A., Xie, C., Zhang, Y., Gao, Y., Wang, H-H., Ye, L-H., Kishi, H., Okagaki, T., Yoshiyama, S., Hayakawa, K., Ishikawa, R., Kohama, K.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 369
  
  Pages: 135-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590240
[Journal Article] Blebbistatin Inhibits the Chemotaxis of Vascular Smooth Muscle Cells through Breaking the Interaction between Myosin II and Actin2008
- Author(s)
  Wang, H-H., Tanaka, H., Qin, X., Zhao, T., Ye, L., Okagaki, T., Katayama, T., Nakamura, A., Ishikawa, R., Thatcher, S., Wright, G., Kohama, K.
- Journal Title
  
  J.Physiol.Heart Circ. Physiol. 294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590240
[Journal Article] Role of non-kinase activity of myosin light-chain kinase in regulating smooth muscle contraction, a review dedicated to Dr. Setsuro Ebashi.2008
- Author(s)
  Nakamura A, Xie C, Zhang Y, Gao Y, Wang HH, Ye LH, Kishi H, Okagaki T, Yoshiyama S, Hayakawa K, Ishikawa R, Kohama K.
- Journal Title
  
  Biochem Biophys Res Commun. 369
  
  Pages: 135-143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590240
[Journal Article] C-protein (MyBP-C) isoforms from carp ordinary and dark muscles and their muscle type specific binding to myosin.2007
- Author(s)
  Okagaki, Suzuki, Ooi.
- Journal Title
  
  Fish. Sci 73
  
  Pages: 638-648
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590218
[Journal Article] Mechanochemical proper- ties of ordinary and dark muscle myosins from seawater fish.2007
- Author(s)
  Okagaki, Yang, Ooi
- Journal Title
  
  Fish. Sci. 73
  
  Pages: 184-188
- NAID
  10018292735
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590218
[Journal Article] Mechanochemical properties of ordinary and dark muscle myosins from seawater fish2007
- Author(s)
  Okagaki, Yang, Ooi
- Journal Title
  
  Fish. Sci. 73
  
  Pages: 184-188
- NAID
  10018292735
- Data Source
  KAKENHI-PROJECT-17590218
[Journal Article] Insight into the mechanism of fast movement of myosin from Chara corallina2007
- Author(s)
  Sumiyoshi, Ooguchi, Ooi, Okagaki, Higashi-Fujime
- Journal Title
  
  Cell Motil. Cytoskel. 64
  
  Pages: 131-142
- Data Source
  KAKENHI-PROJECT-17590218
[Journal Article] Insight into the mechanism of fast movement of myosin from Chara corallina.2007
- Author(s)
  Sumiyoshi, Ooguchi, Ooi, Okagaki, Higashi-Fujime
- Journal Title
  
  Cell Motil. Cytoskel 64
  
  Pages: 131-142
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590218
[Journal Article] Insight into the mechanism of fast movement of myosin from Chara corallina.2007
- Author(s)
  Sumiyoshi, Ooguchi, Ooi, Okagaki, Higashi- Fujime
- Journal Title
  
  Cell Motil. Cytoskel 64
  
  Pages: 131-42
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590218
[Journal Article] C-protein (MyBP-C) isoforms from carp ordinary and dark muscles and their muscle type specific binding to myosin.2007
- Author(s)
  Okagaki, Suzuki, Ooi
- Journal Title
  
  Fish. Sci. 73
  
  Pages: 638-648
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590218
[Journal Article] Mechanochemical properties of ordinary and dark muscle myosins from seawater fish2007
- Author(s)
  Okagaki, Yang, Ooi
- Journal Title
  
  Fish. Sci 73
  
  Pages: 184-188
- NAID
  10018292735
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590218
[Journal Article] Biochemical properties of ordinary and dark muscle myosin from carp skeletal muscle2005
- Author(s)
  Okagaki, Takami, Hosokawa, Yano, Higashi-Fujime, Ooi
- Journal Title
  
  J.Biochem 138
  
  Pages: 255-262
- NAID
  10017346892
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590218
[Journal Article] A calmodulin-dependent protein kinase from lower eukaryote Physarum polycephalum2005
- Author(s)
  Nakamura, A., Hanyuda, Y., Okagaki, T., Takagi, T., Kohama, K.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 328
  
  Pages: 838-844
- Data Source
  KAKENHI-PROJECT-15590224
[Journal Article] A calmodulin-dependent protein kinase from lower eukaryote Physarum polycephalum.2005
- Author(s)
  Nakamura, A., Hanyuda, Y., Okagaki, T., Takagi T, Kohama, K.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 328
  
  Pages: 838-844
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590224
[Journal Article] A calmodulin-dependent protein kinase from lower eukaryote Physarum polycephalum.2005
- Author(s)
  Nakamura A, Hanyuda Y, Okagaki T, Takagi T, Kohama K
- Journal Title
  
  Biochem Biophys Res Commun. 328
  
  Pages: 838-844
- Data Source
  KAKENHI-PROJECT-17590218
[Journal Article] Biochemical properties of ordinary and dark musclemyosin from carp skeletal muscle2005
- Author(s)
  Okagaki, Takami, Hosokawa, Yano, Higashi-Fujime, Ooi
- Journal Title
  
  J. Blochein. 138
  
  Pages: 255-262
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590218
[Journal Article] A calmodulin-dependent protein kinase from lower eukaryote Physarum polycephalum2005
- Author(s)
  Nakamura, Hanyuda, Okagaki, Takagi, Kohama.
- Journal Title
  
  Biochem. Biophys. Res. Common 328
  
  Pages: 838-844
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590218
[Journal Article] Biochemical properties of ordinary and dark muscle myosin from carp skeletal muscle2005
- Author(s)
  Okagaki T, Takami M, Hosokawa K, Yano M, Higashi-Fujime S, Ooi A
- Journal Title
  
  J.Biochem 138
  
  Pages: 255-262
- NAID
  10017346892
- Data Source
  KAKENHI-PROJECT-17590218
[Journal Article] A calmodulin-dependent protein kinase from lower eukaryote Physarum polycephalum2005
- Author(s)
  Nakamura, Hanyuda, Okagaki, Takagi, Kohama
- Journal Title
  
  Biochem. Biophys. Res. Commun. 328
  
  Pages: 838-844
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590218
[Journal Article] Biochemical properties of ordinary and dark muscle myosin from carp skeletal muscle.
- Author(s)
  Okagaki, T., Takami, M., Hosokawa, K., Yano, M., Higashi-Fujime, S., Ooi, A.
- Journal Title
  
  J.Biochem., (on revision)
- NAID
  10017346892
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590224
[Journal Article] Biochemical properties of ordinary and dark muscle myosin from carp skeletal muscle
- Author(s)
  Okagaki, T., Takami, M., Hosokawa, K., Yano, M., Higashi-Fujime, S., Ooi, A.
- Journal Title
  
  J.Biochem. (on revision)
- NAID
  10017346892
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590224
[Presentation] コイ筋原線維ATPase活性のCa-感受性に対するCタンパク質の効果2013
- Author(s)
  岡垣壮、西村陽平、磯西啓太、別府はるか、戸澤彩香、大井淳史
- Organizer
  平成25年度日本水産学会秋季大会
- Place of Presentation
  三重大学(津市)
- Data Source
  KAKENHI-PROJECT-22590240
[Presentation] コイ筋原線維ATPase活性のCa-感受性に対するCタンパク質の効果2013
- Author(s)
  岡垣壮、西村陽平、磯西啓太、別府はるか、戸澤彩香、大井淳史
- Organizer
  日本水産学会秋季大会
- Place of Presentation
  三重大学
- Data Source
  KAKENHI-PROJECT-22590240
[Presentation] Screening of phenotype-specific genes of vascular smooth muscle cell (VSMC) and their characterization2008
- Author(s)
  Miyamoto H., Nagahama R., Nakamura A., Kohama K., Okagaki T.
- Organizer
  The 81^<st> Annual Meeting of the Japanese Pharmacological Society
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-19590240
[Presentation] Blebbistatin inhibits the chemotaxis of vascular smooth muscle cells through breaking the interaction between smooth muscle myosin II and actin2008
- Author(s)
  Wang H-H., Tanaka H., Qin X., Zhao T., Lihong Ye, Okagaki T., Katayama T., Nakamura A., Ishikawa R., Thatcher S. E., Wright G. L., Kohama K.
- Organizer
  The Joint Biophysical Society 52^<nd> Annual Meeting and 16th International Biophysics Congress
- Place of Presentation
  California
- Data Source
  KAKENHI-PROJECT-19590240
[Presentation] 培養血管平滑筋細胞を使った形質変換特異的遺伝子のスクリーニング2007
- Author(s)
  長濱良治, 宮本洋行, 中村彰男, 小濱一弘, 岡垣壮
- Organizer
  15^<th> 日本血管生物医学会学術大会
- Place of Presentation
  Fukuoka
- Data Source
  KAKENHI-PROJECT-19590240

1. KOHAMA Kazuhiro (30101116)

# of Collaborated Projects: 10 results

# of Collaborated Products: 7 results
2. ISHIKAWA Ryoki (20212863)

# of Collaborated Projects: 9 results

# of Collaborated Products: 5 results
3. NAKAMURA Akio (30282388)

# of Collaborated Projects: 8 results

# of Collaborated Products: 12 results
4. OOI Atsushi (70203693)

# of Collaborated Projects: 3 results

# of Collaborated Products: 18 results
5. KISHI Hiroko (40359899)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 今村道博 (80221787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SAIDA Koichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SIENTーGYORGY アンド.リュー

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NYITRAY Lasz

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OKAGAKI Tsuyoshi 岡垣 壮

Research Projects

Research Products

Co-Researchers

Elucidation of cellular network for plastic change of vascular smooth muscle cell.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of transformation of vascular smooth muscle cell-MicroRNA as regulating factor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Screening of genes those are related to dynamic transition of myofiber of vascular smooth muscle cell upon phenotypic modulation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of stabilization and degradation mechanism of muscle fiber of vascular smooth muscle cell upon transformatioonPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the function of myosin-stabilizing protein in living smooth muscle cellPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structure and function of Ca-sensitive myosins

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Refulatory activity of myosin light chain kinase in smooth muscle cell

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

心筋ミオシン軽鎖キナーゼのアクチン結合を介した新しい収縮制御様式の検討

Principal Investigator

Project Period (FY)

Research Category

Research Institution

平滑筋ミオシン結合蛋白質のミオシン線維形成と安定化における機能の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular approach to the structure and function of myosin light chain kinase

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

平滑筋ミオシン線維を安定化させるミオシン結合蛋白の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Screening for the smooth muscle relaxants

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

多機能性カルシウム結合蛋白質:カルシウム抑制因子の構造と機能Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

OKAGAKI Tsuyoshi 岡垣壮