HARA Hisato 原尚人

Researcher Number	80189688
Other IDs
Affiliation (based on the past Project Information) *help	2011 – 2013: 筑波大学, 医学医療系, 教授 1994 – 1998: 筑波大学, 臨床医学系, 講師 1990: Tokyo Women's Medical College, Depatment of Endocrine Surgery, Assistant, 医学部, 助手
Review Section/Research Field	Principal Investigator General surgery / General surgery Except Principal Investigator General surgery
Keywords	Principal Investigator 甲状腺癌 / 癌遺伝子 / ｍＴＯＲ / mTOR / 褐色細胞腫 / 乳頭癌 / APC / 家族性大腸ポリポ-ジス / APC遺伝子 / 家族性大腸ポリポージス / ヨード摂取 / 穿刺吸引細胞診 / ras … More Except Principal Investigator … More ICFBP / IGF-I / Thyroid cancer / 症遺伝子 / 副腎皮質癌 / インスリン様成長因子受容体 / 副腎皮質腫瘍 / インスリン様成長因子結合蛋白 / インスリン様成長因子 / 甲状腺癌 / Catecolamine / Leucine-enkephalin / Methionine-enkephalin / Pheocromocytoma / アドレナリン / ロイシン・エンケファリン / メチオニン・エンケファリン / カテコ-ルアミン / ロイシンーエンケファリン / メチオニンーエンケファリン / 褐色細胞腫 Less

Basic research of mechanism of malignant pheochromocytomaPrincipal Investigator
- Principal Investigator
  
  HARA Hisato
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  University of Tsukuba
家族性大腸ポリポージスを伴う、甲状腺乳頭癌新亜型の臨床、遺伝子学的研究Principal Investigator
- Principal Investigator
  
  原尚人
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General surgery
- Research Institution
  University of Tsukuba
癌遺伝子解析によるヨード摂取が甲状腺癌発生にあたえる影響の研究Principal Investigator
- Principal Investigator
  
  原尚人
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General surgery
- Research Institution
  University of Tsukuba
穿刺吸引細胞診を利用した甲状腺分化癌における癌遺伝子、癌抑制遺伝子の臨床的検討Principal Investigator
- Principal Investigator
  
  原尚人
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General surgery
- Research Institution
  University of Tsukuba
Insulin-like growth factors (IGFs). their receptors, and IGF binding proteins in human endocrine cancer
- Principal Investigator
  
  YASHIRO Tohru
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  University of Tsukuba
甲状腺乳頭癌における予後因子としてのras遺伝子の検討Principal Investigator
- Principal Investigator
  
  原尚人
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General surgery
- Research Institution
  University of Tsukuba
The Clinical Evaluation of Enkephalin as Tumor Marker for Pheochromocytoma and its Physiopathological Significance.
- Principal Investigator
  
  FUJIMOTO Yoshihide, 児玉孝也
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Tokyo Women's Medical College

All 2014 2013 2012 2011

All Journal Article Presentation

[Journal Article] Inhibition of Autophagy Enhances Sunitinib-Induced Cytotoxicity in Rat Pheochromocytoma PC12 cells2013
- Author(s)
  Tatsuhiko Ikeda, Kiyo-aki Ishii, Yuria Saito, Masahiro Miura, Aoi Otagiri, Yasushi Kawakami, Hitoshi Shimano, Hisato Hara, Kazuhiro Takekoshi
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 121 Issue: 1 Pages: 67-73
- DOI
  10.1254/jphs.12158FP
- NAID
  10031147588
- ISSN
  1347-8613, 1347-8648
- URL
  https://pure.teikyo.jp/en/publications/a3c11b15-00b4-41c7-bc8e-f37b414a948a
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591889
[Journal Article] Sunitinib inhibits catecholamine synthesis and secretion in pheochromocytoma tumor cells by blocking vegf receptor 2 via plc-7-related pathways2012
- Author(s)
  Yuichi Aita, Kiyo-aki Ishii, Yuria Saito, Tatsuhiko Ikeda, Yasushi Kawakami, Hitoshi Shimano, Hisato Hara, Kazuhiro Takekoshi
- Journal Title
  
  American Journal of Physiology-Endocrinology and Metabolism
  
  Volume: 303 Issue: 8 Pages: E1006-E1014
- DOI
  10.1152/ajpendo.00156.2012
- URL
  https://localhost/en/publications/0859cf4e-9e3c-4207-b7a4-15c33484cdd8
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591889, KAKENHI-PROJECT-23659473
[Journal Article] Sunitinib induces Apoptosis in Pheochromocytoma Tumor Cells by Inhibiting VEGFR2/AKT/mTOR/S6K1 Pathways Through Modulation of Bcl-2 and BAD2012
- Author(s)
  Saito Y, et al.
- Journal Title
  
  American Journal of Physiology Endocrinology and Metabolism
  
  Volume: 302 Issue: 6 Pages: 615-625
- DOI
  10.1152/ajpendo.00035.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591168, KAKENHI-PROJECT-23591889, KAKENHI-PROJECT-23659473
[Journal Article] Identical germline mutations in the TMEM127 gene in two unrelated Japanese patients with bilateral pheochromocytoma2012
- Author(s)
  Takeichi, N.
- Journal Title
  
  Clini Endocrinol.
  
  Volume: 77 Issue: 5 Pages: 707
- DOI
  10.1111/j.1365-2265.2012.04421.x
- URL
  https://localhost/en/publications/698faa5c-8403-43fc-a912-5d8f0b000b1c
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390212, KAKENHI-PROJECT-23591889, KAKENHI-PROJECT-23659473
[Presentation] ラット褐色細胞腫細胞PC12においてスニチニブによるアポトーシス作用はオートファジー抑制により亢進する2014
- Author(s)
  池田達彦、石井清朗、竹越一博、島野仁、原尚人
- Organizer
  日本外科学会
- Place of Presentation
  京都
- Year and Date
  2014-04-04
- Data Source
  KAKENHI-PROJECT-23591889
[Presentation] mTORC1およびmTORC2阻害のラット褐色細胞腫細胞に対する作用機序の検討2013
- Author(s)
  池田達彦、石井清朗、竹越一博、島野仁、原尚人
- Organizer
  日本内分泌外科学会
- Place of Presentation
  山形
- Year and Date
  2013-05-23
- Data Source
  KAKENHI-PROJECT-23591889
[Presentation] mTOR阻害薬のラット褐色細胞腫細胞に対する作用機序の解明2011
- Author(s)
  池田達彦、石井清朗、竹越一博、島野仁、原尚人
- Organizer
  日本内分泌外科学会
- Place of Presentation
  東京
- Year and Date
  2011-07-07
- Data Source
  KAKENHI-PROJECT-23591889

1. FUJIMOTO Yoshihide (10010167)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. TAKEKOSHI Kazuhiro (40261804)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. ISHII Kiyoaki (80419150)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. YASHIRO Tohru (20157978)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 児玉孝也 (30161946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 平山章 (80075217)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HARA Hisato 原 尚人

Research Projects

Research Products

Co-Researchers

Basic research of mechanism of malignant pheochromocytomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

家族性大腸ポリポージスを伴う、甲状腺乳頭癌新亜型の臨床、遺伝子学的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

癌遺伝子解析によるヨード摂取が甲状腺癌発生にあたえる影響の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

穿刺吸引細胞診を利用した甲状腺分化癌における癌遺伝子、癌抑制遺伝子の臨床的検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Insulin-like growth factors (IGFs). their receptors, and IGF binding proteins in human endocrine cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

甲状腺乳頭癌における予後因子としてのras遺伝子の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Clinical Evaluation of Enkephalin as Tumor Marker for Pheochromocytoma and its Physiopathological Significance.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Inhibition of Autophagy Enhances Sunitinib-Induced Cytotoxicity in Rat Pheochromocytoma PC12 cells2013

Author(s)

Journal Title

DOI

NAID

ISSN

URL

Language

Data Source

[Journal Article] Sunitinib inhibits catecholamine synthesis and secretion in pheochromocytoma tumor cells by blocking vegf receptor 2 via plc-7-related pathways2012

Author(s)

Journal Title

DOI

URL

Language

Data Source

[Journal Article] Sunitinib induces Apoptosis in Pheochromocytoma Tumor Cells by Inhibiting VEGFR2/AKT/mTOR/S6K1 Pathways Through Modulation of Bcl-2 and BAD2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identical germline mutations in the TMEM127 gene in two unrelated Japanese patients with bilateral pheochromocytoma2012

Author(s)

Journal Title

DOI

URL

Language

Data Source

[Presentation] ラット褐色細胞腫細胞PC12においてスニチニブによるアポトーシス作用はオートファジー抑制により亢進する2014

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

HARA Hisato 原尚人