Tohse Noritsugu 當瀬規嗣

… Alternative Names

Researcher Number	80192657
Other IDs
External Links
Affiliation (Current)	2022: 札幌医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2022: 札幌医科大学, 医学部, 教授 2019 – 2020: 札幌医科大学, 医学部, 教授 2007 – 2015: 札幌医科大学, 医学部, 教授 1998 – 2005: School of Medicine, Sapporo Medical University Professor, 医学部, 教授 1995 – 1997: 札幌医科大学, 医学部, 助教授 1993: 北海道大学, 医学部, 助手 1989 – 1990: 北海道大学, 医学部, 助手
Review Section/Research Field	Principal Investigator General physiology / Basic Section 48020:Physiology-related / General pharmacology / Neurophysiology and muscle physiology Except Principal Investigator Circulatory organs internal medicine / Rehabilitation science/Welfare engineering / Orthopaedic surgery / Medical sociology / General physiology / General pharmacology … More
Keywords	Principal Investigator パッチクランプ / 心筋細胞 / 発生期 / Kチャネル / クローニング / PCR法 / 心筋 / イオンチャネル / カルシウムチャネル / patch clamp … More Except Principal Investigator EDHF / rat / イオンチャネル / 心筋細胞 / ラット / 内皮由来過分極因子 / コネキシン / connexin / EDRF / 心肥大 / 肥大退縮 / アンジオテンシンII受容体拮抗薬 / パッチクランプ法 / SHR / 一過性外向きKチャネル(I_<to>) / 虚血性不整脈 / 筋萎縮 / 生化学 / ミオシン重鎖 / 電気刺激 / 萎縮筋 / 電気生理学 / 微小終板電位 / 終板電位 / 運動器 / 慢性疼痛 / 後根神経節 / 交感神経 / グリア細胞 / 神経ペプチド / 脊髄膠様質細胞 / 集学的治療 / 神経根性疼痛 / 神経根絞扼モデル / 脊髄膠様質 / 慢性腰痛 / 集学的アプローチ / パッチクランプ / ノルエピネフリン / マイクログリア / Na+チャネル / 疼痛関連遺伝子 / CGRP / galanin / 二次医療圏 / レセプトデータ / 医療格差 / 医療機能 / 医療サービス / 社会構造の変化 / 医療圏 / 医療資源配分 / 社会構造 / 医療の地域格差 / 医療へのアクセス / 疾病構造 / 医療機会の公平性 / 医療システム / 医療・保健・福祉 / 医療社会学 / 医療経済学 / 医療情報 / 医療の効率性 / heart primordium / E-C coupling / calcium transient / α-cardiac actin / troponin-C / ボツリヌス菌C_3毒素 / 低分子G蛋白 / チロシンキナーゼ / インスリン / 百日咳菌毒素 / alpha_1-受容体 / ウサギ単一心筋細胞 / αー受容体 / Ito / Ik / ボツリヌス毒素 / ボツリヌスC型毒素 / 一過性外向き電流 / α-受容体 / 単一心筋細胞 / Botulinum C_3 toxin / Small G protein / Tyrosin kinase / Insulin / Ion channel / Single myocardial cell / Pertussis toxin / alpha_1-adrenoceptor / カリウムチャンネル / 腸間膜動脈 / 静止膜電位 / エストロゲン / 卵巣摘出 / カリウムチャネル / 腸間脈動脈 / endothelium-derived hyperpolarizing factor / potassium channel / mesenteric artery / resting membrane potential / estrogen / ovariectomy / 虚血 / アポトーシス / リモデリング / 心室細動 / 心室頻拍 / ミトコンドリア / 一酸化窒素 / 拍動リズム / 細胞死 / 再灌流 / ischemia / apoptosis / remodeling / ventricular fibrillation / ventricular tachycardia / mitochondria / nitric oxide / 肺高血圧 / 血管平滑筋 / アドレナリンα受容体 / プロポフォール / 肺高血圧症 / 吸入麻酔薬 / pulmonary hypertension / vascular smooth muscle / adrenergic α receptor / propofol / 血管内皮 / 平滑筋細胞 / 血管 / 血管弛緩因子 / ギャップジャンクション / endothelium / smooth muscle / artery / vasorelaxing factor / ion channel / gap junction Less

低酸素誘導因子1α が胎生初期心臓原基の拍動開始および拍動維持に及ぼす影響の検討Principal Investigator
- Principal Investigator
  
  當瀬規嗣
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Sapporo Medical University
胎児心臓においてミトコンドリア機能が心拍動開始時に果たす役割の機序の解明Principal Investigator
- Principal Investigator
  
  當瀬規嗣
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Sapporo Medical University
The relationship between the calcium transient and contraction in rat heart primordium.
- Principal Investigator
  
  Kobayashi Takeshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Sapporo Medical University
Research on establishment of Regional Medical Care Zones for efficient use of medical resources and by re-organization
- Principal Investigator
  
  YAMAGUCHI Tokuzo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical sociology
- Research Institution
  Sapporo Medical University
Analysis of mechanisms of heartbeat initiation in embryonic stagePrincipal Investigator
- Principal Investigator
  
  TOHSE Noritsugu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Sapporo Medical University
Study of mechanism and treatment of chronic musculoskeletal pain.
- Principal Investigator
  
  YAMASHITA Toshihiko
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Sapporo Medical University
Clarification of molecular mechanisms of endothelium-derived hyperpolarizing factor
- Principal Investigator
  
  FUKAO Mitsuhiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  SAPPORO MEDICAL UNIVERSITY
萎縮筋に対するストレッチ及び電気刺激の影響
- Principal Investigator
  
  乾公美
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  Sapporo Medical University
Analysis of physiological function of calcium channel β subunit in heart musclePrincipal Investigator
- Principal Investigator
  
  TOHSE Noritsugu
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Sapporo Medical University
Effects of volatile anesthetics on pulmonary vasoactivity in rats with pulmonary hypertension.
- Principal Investigator
  
  SEKI Sumihiko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  KANAZAWA MEDICAL UNIVERSITY
  Sapporo Medical University
Ischemia-induced remodeling of the heart : macro- and micro-systems approach to heart function
- Principal Investigator
  
  KAWAHARA Koichi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  HOKKAIDO UNIVERSITY
アデノウイルスベクターを用いた心筋イオンチャネル病の病態解明Principal Investigator
- Principal Investigator
  
  當瀬規嗣
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Sapporo Medical University
A study forthe effects of estrogen on actions ofendothelium-derived hyperpolarizing factor
- Principal Investigator
  
  SAKUMA Ichiro
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  HOKKAIDO UNIVERSITY
Analysis of molecular structure of inward rectifier K channel consisting of three subchannelPrincipal Investigator
- Principal Investigator
  
  TOHSE Noritsugu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Sapporo Medical University
発生期心筋のDNAライブラリー作成とそれによるKチャネル発生過程の検討Principal Investigator
- Principal Investigator
  
  當瀬規嗣
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Sapporo Medical University
ヒスタミンH_1受容体を介した心筋ムスカリン性Kチャネル抑制のシグナル伝達系Principal Investigator
- Principal Investigator
  
  當瀬規嗣
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Sapporo Medical University
膜電流解析を用いた肥大心における虚血性不整脈の発生機序とその予防に関する検討
- Principal Investigator
  
  甲谷哲郎
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Hokkaido University
糖尿病病態による心筋Na-Kポンプ電流の修飾Principal Investigator
- Principal Investigator
  
  當瀬規嗣
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General pharmacology
- Research Institution
  Hokkaido University
EFFECTS OF LOW-MOLECULAR GTP BINDING PROTEINS AND TYROSINE KINASE ACTIVATION ON ION CHANNELS OF MYOCARDIAL CELLS.
- Principal Investigator
  
  KANNO Morio
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  HOKKAIDO UNIVERSITY SCHOOL OF MEDICINE

All 2020 2019 2014 2013 2012 2011 2009 2008 2007 2006 2004 2001

All Journal Article Presentation

[Journal Article] Characteristics of voltage dependent inward current in the rat embryonic heart early after the initiation of heart beat.2013
- Author(s)
  Sato T, Ichise N, Kobayashi T, Maeda S, Tohse N.
- Journal Title
  
  J Physiol Sci
  
  Volume: 63
- Data Source
  KAKENHI-PROJECT-22500365
[Journal Article] High sensitivity western blotting method revealed the developmental changes in the contractile proteins of rat embryonic hearts.2013
- Author(s)
  Kobayashi T, Maeda S, Ichise N, Sato T, Miyakawa T, Yamada Y, Tohse N.
- Journal Title
  
  J Physiol Sci
  
  Volume: 63
- Data Source
  KAKENHI-PROJECT-22500365
[Journal Article] Developmental expression of sarcomeric-related proteins in the period of heart-beat initiation in early rat embryo.2012
- Author(s)
  Maeda S, Kobayashi T, Tohse N
- Journal Title
  
  J Physiol Sci
  
  Volume: 62
- Data Source
  KAKENHI-PROJECT-22500365
[Journal Article] The beginning of the calcium transient in rat embryonic heart.2011
- Author(s)
  Kobayashi T, Maeda S, Ichise N, Sato T, Iwase T, Seki S, Yamada Y, Tohse N.
- Journal Title
  
  J Physiol Sci
  
  Volume: 61 Pages: 141-149
- NAID
  10029049869
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500365
[Journal Article] The effects of the sympathetic nerves on lumbar radicular pain. A behavioral and immunohistochemical study.2007
- Author(s)
  Mizuno S, Takebayashi T, Kirita T, Tanimoto K, Tohse N, Yamashita T
- Journal Title
  
  J Bone Joint Surg 89-B
  
  Pages: 1666-1672
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390398
[Journal Article] CSN5/Jab1 inhibits cardiac L-type Ca^<2+> channel activity through protein-protein interactions.2006
- Author(s)
  Kameda K., Fukao M., Kobayashi T., Tsutsuura M., Nagashima M., Yamada Y., Yamashita T., Tohse N.
- Journal Title
  
  J.Mol.Cell.Cardiol. 40(4)
  
  Pages: 562-569
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16500266
[Journal Article] Development of excitation-contraction coupling in Cardiomyocytes2004
- Author(s)
  Noritsugu Tohse
- Journal Title
  
  Japanese Journal of Physiology 54
  
  Pages: 1-6
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370015
[Journal Article] Development of excitation-contraction coupling in cardiomyocytes2004
- Author(s)
  Noritsugu Tohse
- Journal Title
  
  Japanese Journal of Physiology 54
  
  Pages: 1-6
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370015
[Journal Article] Endothelium and diabetes.2004
- Author(s)
  Fukao M., Tohse N.
- Journal Title
  
  J.Smooth Muscle Res. 8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16500266
[Journal Article] イオンチャネル機能の解明2001
- Author(s)
  當瀬規嗣
- Journal Title
  
  札幌医学雑誌 70
  
  Pages: 65-69
- NAID
  110000453491
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370015
[Presentation] Mitochondrial aerobic respiration in the fetal heart is activated just after initiation of the heartbeat.2020
- Author(s)
  Tatsuya Sato, Nobutoshi Ichise, Takeshi Kobayashi, Hiroya Yamazaki, Yoshinori Terashima, Noritsugu Tohse
- Organizer
  第97回日本生理学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07286
[Presentation] 心拍動開始時の胎児ラット心臓原基におけるCa2+ハンドリングに関わる分子発現変化の特徴2020
- Author(s)
  房川祐頼、佐藤達也、一瀬信敏、小林武志、山﨑寛也、寺島嘉紀、當瀬規嗣
- Organizer
  第100回日本生理学会北海道地方会
- Data Source
  KAKENHI-PROJECT-19K07286
[Presentation] Energy metabolism in rat fetal hearts just after the initiation of heartbeat is altered via increased glycolytic flux and activated mitochondrial function.2020
- Author(s)
  Tatsuya Sato, Nobutoshi Ichise, Takeshi Kobayashi, Hiroya Yamazaki, Yoshinori Terashima, Noritsugu Tohse
- Organizer
  64th Annual Meeting of the Biophysical Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07286
[Presentation] ラット胎生心の心拍動開始時におけるミトコンドリア機能の検討2019
- Author(s)
  佐藤達也、一瀬信敏、山﨑寛也、小林武志、寺島嘉紀、千葉充将、當瀬規嗣
- Organizer
  第99回日本生理学会北海道地方会
- Data Source
  KAKENHI-PROJECT-19K07286
[Presentation] The developmental changes in the contractile proteins of rat embryonic hearts around the period of the appearance of the heartbeat.2014
- Author(s)
  Takeshi Kobayashi, Sachiko Maeda, Nobutoshi Ichise, Tsuyoshi Miyakawa, Izaya Ogon, Yoichi Yamada, Noritsugu Tohse
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学
- Data Source
  KAKENHI-PROJECT-25460295
[Presentation] 神経根絞扼モデルラットの後根神経節におけるアドレナリン受容体の電気生理学的検討2009
- Author(s)
  谷本勝正、竹林庸雄、水野諭、寺島嘉紀、山下敏彦、桐田卓、小林武志、前田佐知子、當瀬規嗣
- Organizer
  北海道整形災害外科学会
- Place of Presentation
  札幌市
- Year and Date
  2009-01-24
- Data Source
  KAKENHI-PROJECT-19390398
[Presentation] Contribution of sympathetic nervous system on lumbar radicular pain Electrophysiological study using patch clamp recordings.2009
- Author(s)
  Tanimoto K, Takebayashi T, Kirita T, Mizuno S, Terashima Y, Kobayashi T, Tohse N, Yamashita T
- Organizer
  Orthropaedic Research Society(ORS)
- Place of Presentation
  Las Vegas, USA
- Year and Date
  2009-02-22
- Data Source
  KAKENHI-PROJECT-19390398
[Presentation] 神経根性疼痛への交感神経の関与-パッチクランプ法による電気生理学的研究-2008
- Author(s)
  谷本勝正、竹林庸雄、水野諭、寺島嘉紀、山下敏彦、桐田卓、小林武志、前田佐知子、當瀬規嗣
- Organizer
  日本整形外科学会基礎学術集会
- Place of Presentation
  京都市
- Year and Date
  2008-10-23
- Data Source
  KAKENHI-PROJECT-19390398
[Presentation] 神経根性疼痛への交感神経の関与-パッチクランプ法による電気生理学的研究-2008
- Author(s)
  谷本勝正、竹林庸雄、水野諭、寺島嘉紀、山下敏彦、桐田卓、小林武志、前田佐知子、當瀬規嗣
- Organizer
  北海道整形災害外科学会
- Place of Presentation
  旭川市
- Year and Date
  2008-06-21
- Data Source
  KAKENHI-PROJECT-19390398

1. KOBAYASHI Takeshi (80363688)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
2. MAKITA Naomasa (00312356)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. ICHISE Nobutoshi (60448610)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. FUKAO Mitsuhiro (10250432)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. YAMASHITA Toshihiko (70244366)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. TAKEBAYASHI Tsuneo (30347166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. ISHIAI Sumio (80193241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KOKAI Yasuo (20178239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MADEA Sachiko (80343391)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAMAGUCHI Tokuzo (80423771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SHINMI Takahiko (10404584)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OHNISHI Hirofumi (20359996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKATSUKA Shintaro (30457733)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TATSUMI Haruyuki (90171719)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MORI Mitsuru (50175634)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KANNO Morio (00109422)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. NAGASHIMA Masato (20264525)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. SAKUMA Ichiro (40260393)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. FUJIMOTO Seiichiro (60001898)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. KAWAHARA Koichi (20125397)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. NISHIURA Yasumasa (00131277)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. YAMAUCHI Yoshiko (50230313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. NAIKI Takeru (40241385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. SEKI Sumihiko (50315503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. TSUCHIDA Hideaki (20155394)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. KANAYA Noriaki (10244344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. HORIO Yoshiyuki (30181530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. YAMADA Yoichi (30284996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 甲谷哲郎 (70205350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 乾公美 (30159959)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 佐藤昇志 (50158937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 佐藤達也 (40592473)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

Tohse Noritsugu 當瀬 規嗣

當瀬 規嗣 トウセ ノリツグ

TOSE Noritsugu 當瀬 規嗣

TOHSE Noritsugu 當瀬 規嗣

Research Projects

Research Products

Co-Researchers

低酸素誘導因子1α が胎生初期心臓原基の拍動開始および拍動維持に及ぼす影響の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

胎児心臓においてミトコンドリア機能が心拍動開始時に果たす役割の機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

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Research Institution

Principal Investigator

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Research Institution

Analysis of mechanisms of heartbeat initiation in embryonic stagePrincipal Investigator

Principal Investigator

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Research Institution

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Principal Investigator

Project Period (FY)

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Principal Investigator

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Analysis of physiological function of calcium channel β subunit in heart musclePrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Principal Investigator

Project Period (FY)

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Research Institution

アデノウイルスベクターを用いた心筋イオンチャネル病の病態解明Principal Investigator

Principal Investigator

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Principal Investigator

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Analysis of molecular structure of inward rectifier K channel consisting of three subchannelPrincipal Investigator

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Tohse Noritsugu 當瀬規嗣

當瀬規嗣トウセノリツグ

TOSE Noritsugu 當瀬規嗣

TOHSE Noritsugu 當瀬規嗣