Hasegawa Takaaki 長谷川高明

… Alternative Names

Researcher Number	80198720
Other IDs
Affiliation (Current)	2019: 愛知医科大学, その他部局等, 名誉教授
Affiliation (based on the past Project Information) *help	2008 – 2010: Aichi Medical University, 医学部, 教授 2004 – 2006: Aichi Medical University, School of Medicine, Professor, 医学部, 教授 1998 – 2003: School of Medicine, Associate Professor, 医学部, 教授 1995 – 1997: 名古屋大学, 医学部, 助教授 1992 – 1993: 名古屋大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator Laboratory medicine / Laboratory medicine Except Principal Investigator General pharmacology / 医学一般 / Kidney internal medicine / Circulatory organs internal medicine
Keywords	Principal Investigator エンドトキシン / トランスポーター / サイトカイン / 生体膜輸送 / Bcrp / TNF-α / 薬物トランスポーター / 胆汁排泄 / 有機アニオン輸送系 / 生体膜輸送機構 … More Except Principal Investigator 神経成長因子 / アルツハイマー型老年期痴呆 / 治療薬 / 学習・記憶 / アセチルコリン作動性神経系 / アセチルコリン合成酵素 / 学習記憶障害 / 脳障害 / 老齢動物 / 中毒情報 / 中毒治療 / 毒物分析 / 日本中毒情報センター / 地域中毒治療センター / 急性中毒 / 薬物分析 / 中毒情報提供 / 集中治療 / 中毒センター / 地域医療 / 情報サービス / POISON INFORMATION / POISONNG THERAPY / POISON ANALYSIS / JAPAN POISONING INFORMATION CENTER / LOCAL POISON CENTER / アルツハイマー型痴呆 / β-アミロイド蛋白 / モデル動物 / アセチルコリン / 神経伝達 / 学習記憶 / プロペントフィリン / メトリフォネイト / アセチルコリンエステラーゼ阻害剤 / 一酸化窒素 / アルツハイマー型痴呆症 / in vivo brain dialysis法 / ニコチン / ドパミン / 毛様体神経栄養因子 / Alzheimer's disease / beta-amyloid protein / learning and memory / animal models / acetylcholine / neuronal transmission / therapeutics / シグマ受容体 / ニューロステロイド / ストレス疾患モデル / 精神分裂病 / 薬物依存 / ストレス疾病モデル / 一酸化窒素(NO) / NO合成阻害薬 / 依存 / phenytoin感受性シグマ1受容体 / ドパミン作動性神経系 / cyclic GMP / Sigma receptors / Neurostereoids / Stress / Schizophrenia / Drug dependence / Learning and memory / ラットネフローゼ / 可溶型CRI / 尿細管間質障害 / 進行性腎障害 / 蛋白尿 / 補体 / 糖尿病性腎症 / ヒト腎疾患 / 進行性賢障害 / アシドーシス / 糖尿病性賢症 / ヒト賢疾患 / 間質障害 / 補体制御因子 / sCR1 / 近位尿細管 / ラット / tubulointerstitial injury / complement activation product / complement / diabetic nephropathy / progressive renal injury / proteinuria / エンドトキシンショック / 心エコー法 / 血小板活性化因子(PAF) / 心機能 / 病理学 / エンドトキシン / 循環器病学 / ENDOTOXIN SHOCK / ECHOCARDIOGRAPHY / PLATELET-ACTIVATING FACTOR (PAF) / CARDIAC FUNCTION / PATHOLOGY Less

Mechanism of expression and function of drug transporters in endotoxemiaPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Takaaki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Aichi Medical University
Molecular pharmacokinetic studies on changes in the expression and function of drug transporters in endotoxemiaPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Takaaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Aichi Medical Univrsity
Molecular pharmacokinetic studies of drug transport in endotoxemiaPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Takaaki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Aichi Medical University
  Nagoya University
Investigation of drug transport function through biological membranes and physiological role in endotoxemiaPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Takaaki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Nagoya University
THE IMPORTANT ROLES OF MEDIATORS IN ENDOTOXIN-INDUCED CARDIOVASCULAR ALTERATIONS
- Principal Investigator
  
  IWASE Mitsunori
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  NAGOYA UNIVERSITY
Elucidation of physiological role of nitric oxide (NO) and cytokines in endotoxemiaPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Takaaki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Nagoya University
Research on The Mechanisms of Tubulointerstitial Injury by Proteinuria.
- Principal Investigator
  
  MATSUO Seiichi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  NAGOYA UNIVERSITY
Role of sigma receptors in the animal models for neuropsychological diseases.
- Principal Investigator
  
  NABESHIMA Toshitaka
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Nagoya University
Development of animal models for Alzheimer's disease
- Principal Investigator
  
  NABESHIMA Toshitaka
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General pharmacology
- Research Institution
  Nagoya University
神経成長因子関連薬物のアルツハイマー型老年期痴呆薬としての可能性について
- Principal Investigator
  
  NABESHIMA Toshitaka
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Nagoya University
Research for establishment of the "Poisoning Research Center", which combined the functions of information, therapy and analysis of poison.
- Principal Investigator
  
  SAWADA Yuhwsuke
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  医学一般
- Research Institution
  Tokai University
  Nagoya University

All 2011 2010 2009 2008 2005 2004 2003 Other

All Journal Article Book

[Book] 臨床への薬物動態学2011
- Author(s)
  長谷川高明
- Total Pages
  299
- Publisher
  廣川書店
- Data Source
  KAKENHI-PROJECT-20590587
[Book] 臨床への薬物動態学2009
- Author(s)
  長谷川高明
- Total Pages
  311
- Publisher
  廣川書店
- Data Source
  KAKENHI-PROJECT-20590587
[Book] 新しい図解薬剤学2004
- Author(s)
  長谷川高明他12名
- Total Pages
  600
- Publisher
  南山堂
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590484
[Journal Article] Endotoxin does not alter the pharmacokinetics of micafungin, but it impairs biliary excretion of micafungin via multidrug resistance associated protein 2 (ABCC2/Mrp2) in rats.2011
- Author(s)
  Noda T, Abe F, Ueyama J, Kato M, Katoh M, Nadai M, Saito H, Hasegawa T
- Journal Title
  
  J.Infect. Chemother. 17
  
  Pages: 207-213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590587
[Journal Article] Involvement of sulfate conjugation and multidrug resistance-associated protein 2 (Mrp2) in sex-related differences in the pharmacokinetics of garenoxacin in rats.2011
- Author(s)
  Hayashi T, Abe F, Kato M, Saito H, Ueyama J, Kondo Y, Imai Y, Katoh M, Nadai M, Hasegawa T
- Journal Title
  
  J.Infect. Chemother. 17
  
  Pages: 24-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590587
[Journal Article] β-Glucuronidase activity is a sensitive biomarker to assess low-level organophosphorus insecticide exposure.2010
- Author(s)
  Ueyama J, Satoh T, Kondo T, Takagi K, Shibata E, Goto M, Kimata A, Saito I, Hasegawa T, Wakusawa S, Kamijima M
- Journal Title
  
  Toxicol Lett. 133
  
  Pages: 115-119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590587
[Journal Article] a novel WD40-repeat protein, mediates spontaneous and tumor necrosis factor-induced apoptosis.2010
- Author(s)
  Feng GG, Li C, Huang L, Tsunekawa K, Sato Y, Fujiwara Y, Komatsu T, Honda T, Fan JH, Goto H, Koide T, Hasegawa T, Ishikawa N, Naofen
- Journal Title
  
  Biochem. Biophys. Res.Commun. 394
  
  Pages: 153-157
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590587
[Journal Article] Active ingredients of traditional Japanese (kampo) medicine, inchinkoto, in murine concanavalin A-induced hepatitis.2010
- Author(s)
  Mase A, Makino B, Tsuchiya N, Yamamoto M, Kase Y, Takeda S, Hasegawa T
- Journal Title
  
  J.Ethnopharmacol. 127
  
  Pages: 742-749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590587
[Journal Article] Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells.2009
- Author(s)
  Matsushima, M., Takagi, K., Ogawa M., Hirose E., Ota Y., Abe F., Baba K., Hasegawa T., Hasegawa T, Kawabe T
- Journal Title
  
  Inflamm.Res. 58
  
  Pages: 705-715
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590587
[Journal Article] Effect of a Kampo preparation, byakkokaninjinto, on pharmacokinetics of ciprofloxacin and tetracycline.2009
- Author(s)
  Ohnishi M, Hitoshi K, Katoh M, Nadai M, Abe F, Kurono S, Haniuda M, Saito H, Hasegawa T
- Journal Title
  
  Biol.Pharm.Bull. 32
  
  Pages: 1080-1084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590587
[Journal Article] Urinary excretion of 3-phenoxybenzoic acid in middle-aged and elderly general population of Japan.2009
- Author(s)
  Ueyama J, Kimata A, Kamijima M, Hamajima N, Ito Y, Suzuki K, Inoue T, Yamamoto K, Takagi K, Saito I, Miyamoto K.-I, Hasegawa T, Kondo T
- Journal Title
  
  Environ.Res. 109
  
  Pages: 175-180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590587
[Journal Article] Effect of the organophosphoruspesticide diazinon on glucose tolerance in type 2 diabetic rats.2008
- Author(s)
  Ueyama J, Kamijima M, Asai K, Mochizuki A, Wang D, Kondo T, Suzuki T, Takagi K, Takagi K, Kanazawa H, Miyamoto K, Wakusawa S, Hasegawa T
- Journal Title
  
  Toxicol. Lett. 182
  
  Pages: 42-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590587
[Journal Article] Association of serum NOx level with clustering of metabolic syndrome components in middle-aged and elderly general populations in Japan.2008
- Author(s)
  Ueyama J, Kondo T, Imai R, Kimata A, Yamamoto K, Suzuki K, Inoue T, Ito Y, Miyamoto K.-I, Hasegawa T, Hamajima N
- Journal Title
  
  Environ. Health Preventive Med. 13
  
  Pages: 36-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590587
[Journal Article] Role of plasma proteins in pharmacokinetics of micafungin, an antifungal antibiotic, in analbuminemic rats.2008
- Author(s)
  Abe F, Ueyama J, Kawasumi N, Nadai M, Hayashi T, Kato M, Ohnishi M, Saito H, Takeyama N, Hasegawa T
- Journal Title
  
  Antimicrob. Agents Chemother. 52
  
  Pages: 3454-3456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590587
[Journal Article] Involvement of multidrug resistance associated protein 2(ABCC2/Mrp2) in biliary excretion of micafungin in rats.2008
- Author(s)
  Abe F, Ueyama J, Kimata A, Kato M, Hayashi T, Nadai M, Saito H, Takeyama N, Noguchi H, Hasegawa T
- Journal Title
  
  Life Sci. 83
  
  Pages: 229-235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590587
[Journal Article] Effect of Thalidomide on Endotoxin-Induced Decreases in Activity and Expression of Hepatic Cytochrome P450 3A2.2008
- Author(s)
  Ueyama J, Nadai M, Zhao YL, Kanazawa H, Takagi K, Kondo T, Takagi K, Wakusawa S, Abe F, Saito H, Miyamoto K, Hasegawa T
- Journal Title
  
  Biol.Pharm.Bull. 31
  
  Pages: 1598-1600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590587
[Journal Article] Quality of life improvement in patients diagnosed with hormone refractory prostate cancer with bone metastatis as a result of chemotherapy and the administration of zoledronic acid.2008
- Author(s)
  Arakawa M, Saito H, Hasegawa T, Kato Y, Ishikawa K
- Journal Title
  
  Palliative Care Res. 3
  
  Pages: 308-315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590587
[Journal Article] Cyclooxygenase-2 expression in invasive transitional cell carcinoma of the urinary bladder.2008
- Author(s)
  Yamada Y, Nakamura K, Inoue Y, Naruse K, Aoki S, Taki T, Tobiume M, Zennami K, Katsuda R, Hara K, Kyoku I, Mitsutake N, Arakawa M, Saito H, Hasegawa T, Noguchi H, Honda N
- Journal Title
  
  Mol.Med.Reports 1
  
  Pages: 791-795
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590587
[Journal Article] Role of tumor necrosis factor-α in down-regulation of hepatic cytochrome P450 and P-glycoprotein by endotoxin.2005
- Author(s)
  Miyoshi, M., Nadai, M., Nitta, A., Ueyama, J., Shimizu, A., Takagi, K., Nabeshima, T., Takagi, K., Saito, K., Hasegawa, T.
- Journal Title
  
  Eur.J.Pharmacol. 507
  
  Pages: 229-237
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590484
[Journal Article] Endotoxin from various gram-negativebacteria has differential effects on function of hepatic cytochrome P450 and drug transporters.2005
- Author(s)
  Ueyama, J., Nadai, M., Kanazawa, H., Iwase, M., Nakayama, H., Hashimoto, K., Yokoi, T., Baba, K., Takagi, K., Takagi, K., Hasegawa, T.
- Journal Title
  
  Eur.J.Pharmacol. 510
  
  Pages: 127-134
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590484
[Journal Article] A sensitive colometric assay for polyamines in erythrocytesusing oat seedling polyamine oxidase.2004
- Author(s)
  Takagi, K., Tatsumi, Y., Kitaichi, K., Iwase, M., Shibata, E., Nakao, M., Matsumoto, T., Takagi, K., Hasegawa, T.
- Journal Title
  
  Clinica.Chemica.Acta 340
  
  Pages: 219-227
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590484
[Journal Article] Azithromycin reverses anticancer drug-resistance and modifies hepatobiliary excretion of doxorubicin in rats.2004
- Author(s)
  Asakura, E., Nakayama, H., Sugie, M., Zhao, Y.L., Nadai, M, Kitaichi, K., Shimizu, A., Miyoshi, M., Takagi, K., Takagi, K., Hasegawa, T.
- Journal Title
  
  Eur.J.Pharmacol. 484
  
  Pages: 333-339
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590484
[Journal Article] Effect of pioglitazone on endotoxin-induced decreases in hepatic drug-metabolizing enzyme activity andexpression of CYP3A2 and CYP2C11.2004
- Author(s)
  Ueyama, J., Kitaichi, K., Nadai, M., Iwase, M., Tomyo, N., Kanazawa, H., Suzuki, R., Takagi, K., Takagi, K., Hasegawa, T.
- Journal Title
  
  Eur.J.Pharmacol. 498
  
  Pages: 257-265
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590484
[Journal Article] Possible involvement of P-glycoprotein in renal excretion of pazufloxacin in rats.2004
- Author(s)
  Shimizu, A., Miyoshi, M., Sugie, M., Ueyama, J., Yamaguchi, T., Sasaki, T., Takagi, K., Kim, M., Miyamoto, K., Tsuji, A., Hasegawa, T.
- Journal Title
  
  Eur.J.Pharmacol. 501
  
  Pages: 151-159
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590484
[Journal Article] Possible involvement of drug transporters P-glycoproteinand multidrug resistance-associated protein Mrp2 indisposition of azithromycin.2004
- Author(s)
  Sugie, M., Asakura, E., Zhao, Y.L., Torita, S., Nadai, M., Baba, K., Kitaichi, K., Takagi, K., Takagi, K., Hasegawa, T.
- Journal Title
  
  Antimicrob.Agents Chemother. 48
  
  Pages: 809-814
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590484
[Journal Article] The altered disposition of methamphetamine in the model of methamphetamine-induced neurotoxicity.2004
- Author(s)
  Kitaichi, K., Ito, Y., Fukuda, M., Aoyama, N., Nakayama, H., Takagi, K., Hasegawa, T.
- Journal Title
  
  Ann.N.Y.Acad.Sci. 1025
  
  Pages: 248-256
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590484
[Journal Article] Role of tumor necrosis factor-a in methamphetamine-induced drug dependence and neurotoxicity.2004
- Author(s)
  Nakajima, A., Yamada, K., Nagai, T., Uchiyama, T., Miyamoto, Y., Mamiya, T., He, J., Nitta, A., Mizuno, M., Tran, M.H., Seto, A., Yoshimura, M., Kitaichi, K., Hasegawa, T., Saito, K., Yamada, Y., Seishima, M., Sekikawa, K., Kim, H.-C., Nabeshima, T.
- Journal Title
  
  J.Neurosci. 24
  
  Pages: 2212-2225
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590484
[Journal Article] Down-regulation of cytochrome P450 proteins and its activities by Shiga-like toxin II from Escherichia. coli O157 : H7.2004
- Author(s)
  Kitaichi, K., Nakayama, H., Ueyama, J., Nadai, M., Baba, K., Takagi, K., Takagi, K., Ohta, M., Hasegawa, T.
- Journal Title
  
  Biochem.Pharmacol. 67
  
  Pages: 1427-1435
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590484
[Journal Article] Application of ultrafiltration method to measurement of catecholamines in plasma of human and rodents by high-performance liquid chromatography.2003
- Author(s)
  Ueyama, J., Kitaichi, K., Iwase, M., Takagi, K., Takagi, K., Hasegawa, T.
- Journal Title
  
  J.Chromatogr B. 789
  
  Pages: 35-41
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590484
[Journal Article] Pharmacokinetic-pharmacodynamic study of itraconazole in patientswith fungal infections in intensive care units.
- Author(s)
  Hagihara M, Kasai H, Umemura T, Kato T, Hasegawa T, Mikamo H
- Journal Title
  
  J.Infect. Chemother. 17
  
  Pages: 224-230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590587
[Journal Article] Panipenem does not alter the pharmacokinetics of the active metabolite of irinotecan SN-38 and SN-38 glucuronide (SN-38G) in rats.
- Author(s)
  Kato A, Ueyama J, Abe F, Hotta K, Tukiyama I, Ohshima T, Saito H, Hasegawa T
- Journal Title
  
  Anticancer Res. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590587

1. NABESHIMA Toshitaka (70076751)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. KITAICHI Kiyoyuki (40301220)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
3. TAKAGI Kenji (80126870)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
4. FENG GuoーGang (70351111)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. SAWADA Yuhwsuke (20135685)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAKAGAWA Yoshihide (00246125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YAMAMOTO Isotoshi (70242873)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NAKAJIMA Isao (00183509)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. INOKUCHI Sadaki (60160008)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MATSUO Seiichi (70190410)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NISHIKAWA Kazuhiro (30301625)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YUZAWA Yukio (00191479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. IWASE Mitsunori (20303646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NAGASAKA Teturo (40262894)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. YOKOYA Mitsuhiro (50201851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SAITO Ken-ichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Hasegawa Takaaki 長谷川 高明

HASEGAWA Takaaki 長谷川 高明

長谷川 高明 ハセガワ タカアキ

Research Projects

Research Products

Co-Researchers

Mechanism of expression and function of drug transporters in endotoxemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular pharmacokinetic studies on changes in the expression and function of drug transporters in endotoxemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular pharmacokinetic studies of drug transport in endotoxemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of drug transport function through biological membranes and physiological role in endotoxemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

THE IMPORTANT ROLES OF MEDIATORS IN ENDOTOXIN-INDUCED CARDIOVASCULAR ALTERATIONS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of physiological role of nitric oxide (NO) and cytokines in endotoxemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on The Mechanisms of Tubulointerstitial Injury by Proteinuria.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of sigma receptors in the animal models for neuropsychological diseases.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of animal models for Alzheimer's disease

Principal Investigator

Project Period (FY)

Research Category

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Research Institution

神経成長因子関連薬物のアルツハイマー型老年期痴呆薬としての可能性について

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Research for establishment of the "Poisoning Research Center", which combined the functions of information, therapy and analysis of poison.

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[Book] 臨床への薬物動態学2011

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[Book] 臨床への薬物動態学2009

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Hasegawa Takaaki 長谷川高明

HASEGAWA Takaaki 長谷川高明

長谷川高明ハセガワタカアキ