Shibahara Hiroaki 柴原浩章

… Alternative Names

柴原浩章シバハラヒロアキ

SHIBAHARA Hiroaki 柴原浩章

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Researcher Number	80206143
Affiliation (Current)	2025: 兵庫医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2021: 兵庫医科大学, 医学部, 教授 2017: 兵庫医科大学, 医学部, 教授 2013: 兵庫医科大学, 医学部, 教授 2009 – 2012: 自治医科大学, 医学部, 教授 2000 – 2005: 自治医科大学, 医学部, 助教授 1996 – 1997: 兵庫医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Obstetrics and gynecology / Obstetrics and gynecology Except Principal Investigator Obstetrics and gynecology / Obstetrics and gynecology / Pathology, Infection/Immunology, and related fields
Keywords	Principal Investigator 体外受精 / 受精 / 精子細胞膜蛋白 / 男性不妊症 / 精子受精能獲得 / 精子超活性化 / 精子パラメーター / SMAS / セロトニン / 精子 … More / 男性不妊 / 生殖医療 / sperm surface proteins / intra-cytoplasmic sperm injection / in vitro fertilization / fertilizing ability / anti-sperm antibody / immunological male infertility / 免疫染色 / 二次元電気泳動 / 精子受精機能 / 精子運動機能 / 精子細胞膜タンパク / 顕微授精 / 受精機能 / 抗精子抗体 / 免疫性男性不妊症 / Embryo development / Fertilization / Sperm-immobilizing antibody / Sperm surface protein / GPI-anchored protein / 二次元電気泳動法 / 胚発生 / 免疫性不妊婦人 / 免疫学的避妊ワクチン / 疾患感受性遺伝子 / 胚発生障害 / 受精障害 / 精子不動化抗体 / GPIアンカー蛋白 … More Except Principal Investigator contraception / sperm immobilizing antibody / sperm / infertility / HLA-DQ / HLA-DR / antisprem antibody / autoimmunity / 免疫性不妊症 / トランスレーショナルリサーチ / 免疫学 / IRAK4 / MyD88 / IL-33 / IL-1 / サイトカイン / 子宮内膜症 / Sperm / Anti Sperm antibody / Infertility / Autoimmune disease / HLA / 受精 / 精子 / 透明帯 / 熱ショック蛋白60 / 抗精子抗体 / クラミジア・トラコマティス感染症 / HMGB1 (High Mobility Group Box 1) / TLR(toll like receptor) / クラミジア感染 / クラミジアHSP60 / 卵管性不妊症 / クラミジア・トラコマティス / degenerate Primer / PABP / 無精子症 Less

Development of a novel treatment for male infertility by using SerotoninPrincipal Investigator
- Principal Investigator
  
  Shibahara Hiroaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Hyogo Medical University
Elucidation of immunological onset mechanism of endometriosis and search for preventive/therapeutic techniques
- Principal Investigator
  
  善本知広
- Project Period (FY)
  2017
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Pathology, Infection/Immunology, and related fields
- Research Institution
  Hyogo Medical University
The class classification of anti-ZP antibodies in immunologic infetility women and application to infertility treatment
- Principal Investigator
  
  SUZUKI TATSUYA
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Jichi Medical University
The relationships of Chlamydia Trachomatis heaatshock protein 60 resulting in tubal damage
- Principal Investigator
  
  HIRANO Yuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Jichi Medical University
Identification of corresponding antigens against anti-sperm antibodies with the inhibitory effects on sperm motility and fertilization in infertile men.Principal Investigator
- Principal Investigator
  
  SHIBAHARA Hiroaki
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  JICHI MEDICAL SCHOOL
無精子症の発現に関する新しい候補遺伝子の解明
- Principal Investigator
  
  出居貞義
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Jichi Medical University
Development of immunocontraceptive vaccine using GPI-anchored proteins on the surface of human spermPrincipal Investigator
- Principal Investigator
  
  SHIBAHARA Hiroaki
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Jichi Medical School
INVESTIGATION FOR IMMUNOGENETIC BACKGROUND OF ANTISPERM ANTIBODY,INVOLVEMENT OF HLA-II
- Principal Investigator
  
  TSUJI Yoshiyuki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  HYOGO COLLEGE OF MEDICINE

All 2022 2021 2014 2013 2011 2010 2009 2005 2004 2003

All Journal Article Presentation Book

[Book] V-20抗透明帯抗体.卵子学(編)2011
- Author(s)
  柴原浩章、高見澤聡
- Publisher
  森崇英
- Data Source
  KAKENHI-PROJECT-23592411
[Book] V-4受精と免疫(抗精子抗体、抗透明帯抗体).生命の誕生に向けて〈第二版〉.(編)2011
- Author(s)
  郡山純子、柴原浩章
- Publisher
  日本哺乳動物卵子学会
- Data Source
  KAKENHI-PROJECT-23592411
[Book] Chlamydia trachomatisによる卵管性不妊モデルマウスの作製とその病態解明2009
- Author(s)
  平野由紀/柴原浩章/島田和彦/鈴木光明
- Publisher
  HORMONE FRONTIER
- Data Source
  KAKENHI-PROJECT-21592107
[Book] STDと不妊-クラミジア・トラコマティス感染症を中心に-2009
- Author(s)
  平野由紀、柴原浩章、島田和彦、鈴木光明
- Data Source
  KAKENHI-PROJECT-21592107
[Book] ここが聞きたい不妊・不育診療ベストプラクティス2009
- Author(s)
  平野由紀、柴原浩章、永山志穂、大丸貴子、高見澤聡、鈴木光明
- Data Source
  KAKENHI-PROJECT-21592107
[Journal Article] Infertility and Immunocontraception based on zona pellucida2014
- Author(s)
  Hasegawa A, Tanaka H, Shibahara H
- Journal Title
  
  Reprod Med Biol
  
  Volume: 13 Pages: 1-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592411
[Journal Article] Toward standardization of the cut-off value for the direct immunobead test using the postcoital test in immunologically infertile males.2013
- Author(s)
  Junko Koriyama, Hiroaki Shibahara, Tomoe Ikeda, Yuki Hirano, Tatsuya Suzuki, Mitsuaki Suzuki.
- Journal Title
  
  Reprod Med Biol
  
  Volume: 12 Issue: 1 Pages: 21-25
- DOI
  10.1007/s12522-012-0135-8
- NAID
  10031147304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592411
[Journal Article] Incidence of sperm immobilizing antibodies in infertile women with past Chlamydia trachomatis infection2011
- Author(s)
  Hirano Y, Shibahara H, Koriyama J, Tokunaga M, Shimada K, Suzuki M
- Journal Title
  
  Am J Reprod Immunol
  
  Volume: 65 Pages: 127-132
- Data Source
  KAKENHI-PROJECT-21592107
[Journal Article] Diagnosis and treatment of immunologically infertile males with anti-sperm antibodies.(Review article)2005
- Author(s)
  Shibahara H, et al.
- Journal Title
  
  Reprod Med Biol 4
  
  Pages: 133-141
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591776
[Journal Article] Serum matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) concentrations in infertile women achieved pregnancy following IVF-ET.2005
- Author(s)
  Shibahara H, et al.
- Journal Title
  
  Am.J.Reprod.Immunol. 54
  
  Pages: 186-192
- Data Source
  KAKENHI-PROJECT-15591776
[Journal Article] Severe ovarian hyperstimulation syndrome in a 42-year-old woman with successful pregnancy following intracytoplasmic sperm injection-embryo transfer.2005
- Author(s)
  Shibahara H, et al.
- Journal Title
  
  Reprod.Med.Biol. 4
  
  Pages: 265-269
- Data Source
  KAKENHI-PROJECT-15591776
[Journal Article] Doubling time of urine human chorionic gonadotropin after assisted reproductive technology.2005
- Author(s)
  Fujiwara H, Shibahara H, et al.
- Journal Title
  
  Fertil.Steril. 84
  
  Pages: 1040-1042
- Data Source
  KAKENHI-PROJECT-15591776
[Journal Article] Feasibility and clinical significance of endoluminal assessment by transvaginal salpingoscopy under transvaginal hydrolaparoscopy in infertile women.2005
- Author(s)
  Suzuki T, Shibahara H, et al.
- Journal Title
  
  J.Minim.Invasive Gynecol. 12
  
  Pages: 420-425
- Data Source
  KAKENHI-PROJECT-15591776
[Journal Article] Diagnosis and treatment of immunologically infertile males with anti-sperm antibodies. (Review article)2005
- Author(s)
  Shibahara H, et al.
- Journal Title
  
  Reprod. Med. Biol. 4
  
  Pages: 133-141
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591776
[Journal Article] Diagnosis and treatment of immunologically infertile males with anti-sperm antibodies.2005
- Author(s)
  Shibahara H, et al.
- Journal Title
  
  Reprod.Med.Biol. 4
  
  Pages: 133-141
- NAID
  10015654708
- Data Source
  KAKENHI-PROJECT-15591776
[Journal Article] Serum leptin concentrations in patients with severe OHSS during IVF-ET.2004
- Author(s)
  Ayustawati, Shibahara H, et al.
- Journal Title
  
  Fertil.Steril. 82
  
  Pages: 579-585
- Data Source
  KAKENHI-PROJECT-15591776
[Journal Article] The risk of birth defects in dichorionic twins conceived by assisted reproductive technology.2004
- Author(s)
  Kuwata T, Shibahara H, et al.
- Journal Title
  
  Twin Res. 7
  
  Pages: 223-227
- Data Source
  KAKENHI-PROJECT-15591776
[Journal Article] Randomized study comparing day 2 versus day 3 elective transfer of two good-quality embryos.2004
- Author(s)
  Suzuki T, Shibahara H, et al.
- Journal Title
  
  Reprod.Med.Biol. 3
  
  Pages: 99-104
- NAID
  10013086395
- Data Source
  KAKENHI-PROJECT-15591776
[Journal Article] Prediction of pregnancy by intrauterine insemination using CASA estimates and strict criteria in patients with male factor infertility.2004
- Author(s)
  Shibahara H, et al.
- Journal Title
  
  Int.J.Androl. 27
  
  Pages: 63-68
- Data Source
  KAKENHI-PROJECT-15591776
[Journal Article] Prediction of ovarian reserve based on day3 serum HSG concentrations during the pituitary suppression cycle using GnRHa in patients undergoing IVF-ET.2004
- Author(s)
  Onagawa T, Shibahara H, et al.
- Journal Title
  
  Gynecol.Endocrinol. 18
  
  Pages: 335-340
- Data Source
  KAKENHI-PROJECT-15591776
[Journal Article] Diversity of the inhibitory effects on fertilization by anti-sperm antibodies bound to the surface of ejaculated human spermatozoa.2003
- Author(s)
  Shibahara H, et al.
- Journal Title
  
  Hum.Reprod. 18
  
  Pages: 1469-1473
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591776
[Journal Article] Infertile women without sensitization by appropriate amount of sperm do not produce sperm immobilizing antibodies in their sera.2003
- Author(s)
  Shibahara H, et al.
- Journal Title
  
  Reprod.Med.Biol. 2
  
  Pages: 105-108
- NAID
  10012553773
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591776
[Journal Article] Effect of sperm immobilizing antibodies bound to the surface of ejaculated human spermatozoa on sperm motility in immunologically infertile men.2003
- Author(s)
  Shibahara H, et al.
- Journal Title
  
  Fertil.Steril. 79
  
  Pages: 641-642
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591776
[Journal Article] Infertile women without sensitization by appropriate amount of sperm do not produce sperm immobilizing antibodies in their sera.2003
- Author(s)
  Shibahara H, et al.
- Journal Title
  
  Reprod. Med. Biol. 2
  
  Pages: 105-108
- NAID
  10012553773
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591776
[Journal Article] Effects of sperm immobilizing antibodies bound to the surface of ejaculated human spermatozoa on sperm motility in immunologically infertile men.2003
- Author(s)
  Shibahara H et al.
- Journal Title
  
  Fertil. Steril. 79
  
  Pages: 641-642
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591776
[Journal Article] Diversity of the inhibitory effects on fertilization by anti-sperm antibodies bound to the surface of ejaculated human spermatozoa.2003
- Author(s)
  Shibahara H et al.
- Journal Title
  
  Hum. Reprod. 18
  
  Pages: 1469-1473
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591776
[Journal Article] Effects of sera from infertile women with sperm immobilizing antibodies on fertilization and embryo development in vitro in mice.2003
- Author(s)
  Taneichi A, Shibahara H, et al.
- Journal Title
  
  Am.J.Reprod.Immunol. 50
  
  Pages: 146-151
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591776
[Journal Article] Effects of sera from infertile women with sperm immobilizing antibodies on fertilization and embryo development in vitro in mice.2003
- Author(s)
  Taneichi A, Shibahara H, et al.
- Journal Title
  
  Am. J. Reprod. Immunol. 50
  
  Pages: 146-151
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591776
[Presentation] ヒト精子の運動に対するセロトニン(5-HT)の影響2022
- Author(s)
  表摩耶,長谷川昭子,赤田日向子,杉山由希子,脇本裕,藤ノ木政勝,柴原浩章
- Organizer
  第10回関西生殖集談会・第54回関西アンドロロジーカンファレンス合同研究会
- Data Source
  KAKENHI-PROJECT-19K09815
[Presentation] ヒト精子におけるセロトニン（5-HT）レセプターの発現について2021
- Author(s)
  表摩耶,長谷川昭子,赤田日向子,杉山由希子,脇本裕,藤ノ木政勝,柴原浩章
- Organizer
  第62回日本卵子学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09815
[Presentation] ヒト精子におけるセロトニン（5-HT）の作用について2021
- Author(s)
  表摩耶,長谷川昭子,赤田日向子,杉山由希子,脇本裕,藤ノ木政勝,柴原浩章
- Organizer
  第39回日本受精着床学会総会
- Data Source
  KAKENHI-PROJECT-19K09815
[Presentation] V-4受精と免疫(抗精子抗体、抗透明帯抗体).生命の誕生に向けて〈第二版〉.(編)2011
- Author(s)
  郡山純子、柴原浩章
- Organizer
  日本哺乳動物卵子学会
- Data Source
  KAKENHI-PROJECT-23592411
[Presentation] V-20抗透明帯抗体2011
- Author(s)
  柴原浩章、高見澤聡
- Organizer
  卵子学(編)森崇英
- Data Source
  KAKENHI-PROJECT-23592411
[Presentation] Comparison of tubal pathology induced by transvaginal and intraperitoneal inoculation with Chlamydia trachomatis in mice2010
- Author(s)
  Hirano Y, Shibahara H, Shimada K, Suzuki M
- Organizer
  IFFS 20^<th> World Congress on Fertility & Sterility
- Place of Presentation
  Munich、Germany
- Year and Date
  2010-09-14
- Data Source
  KAKENHI-PROJECT-21592107
[Presentation] クラミジア・トラコマティス性卵管性不妊症の病態形成における熱ショック蛋白の役割～クラミジア・トラコマティス二次感染モデルマウスを用いての検討～2010
- Author(s)
  平野由紀、柴原浩章、島田和彦、鈴木光明
- Organizer
  第9回自治医科大学シンポジウム
- Place of Presentation
  下野
- Year and Date
  2010-09-05
- Data Source
  KAKENHI-PROJECT-21592107
[Presentation] 当科における抗クラミジア・トラコマティス抗体保有不妊女性の年次推移2009
- Author(s)
  平野由紀、島田和彦、橘直之、池田伴衣、郡山純子、鈴木達也、高見澤聡、柴原浩章、鈴木光明
- Organizer
  第27回日本産婦人科感染症研究会
- Place of Presentation
  宇都宮
- Year and Date
  2009-06-20
- Data Source
  KAKENHI-PROJECT-21592107
[Presentation] クラミジア・トラコマティス感染既往と抗精子抗体産生との関係2009
- Author(s)
  平野由紀、柴原浩章、郡山純子、白石康子、島田和彦、鈴木光明
- Organizer
  第54回日本生殖医学会
- Place of Presentation
  金沢
- Year and Date
  2009-11-22
- Data Source
  KAKENHI-PROJECT-21592107
[Presentation] 不活化クラミジア・トラコマティス(Ct)菌体でも遅延型過敏反応による卵管傷害の重症化を誘導する2009
- Author(s)
  平野由紀、柴原浩章、島田和彦、鈴木光明
- Organizer
  第61回日本産科婦人科学会
- Place of Presentation
  京都
- Year and Date
  2009-04-05
- Data Source
  KAKENHI-PROJECT-21592107
[Presentation] Comparison of severity of tubal damage induced by active and inactivated Chlamydia trachomatis infection through delayed-type hypersensitivity reaction in Balb/c mice2009
- Author(s)
  Hirano Y., Shibahara H., Shimada K., Suzuki M.
- Organizer
  Bio-immunoregulatory Mechanisms Associated with Reproductive Organs : Relevance in Fertility and in Sexually Transmitted Infections. National Institute of Immunology
- Place of Presentation
  New Delhi, India
- Year and Date
  2009-02-13
- Data Source
  KAKENHI-PROJECT-21592107
[Presentation] クラミジア・トラコマティス感染既往と抗精子抗体産生との関連2009
- Author(s)
  平野由紀、柴原浩章、郡山純子、白石康子、島田和彦、鈴木光明
- Organizer
  第28回日本アンドロロジー学会
- Place of Presentation
  富山
- Year and Date
  2009-07-03
- Data Source
  KAKENHI-PROJECT-21592107
[Presentation] The incidence of anti-sperm antibodies in infertile couples with chlamydia trachomatis infection2009
- Author(s)
  Hirano Y., Shibahara H., Koriyama J., Shiraishi Y., Shimada K., Suzuki M.
- Organizer
  29^<th> Annual Meeting of American Society for Reproductive Immunology
- Place of Presentation
  Orlando, Florida
- Data Source
  KAKENHI-PROJECT-21592107

1. 出居貞義 (50296084)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. HIRANO Yuki (10398521)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
3. SHIMADA Kazuhiko (60424024)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
4. SUZUKI TATSUYA (90348003)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. TSUJI Yoshiyuki (60148658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MITSUO Mizumi (30258157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TAKAMIZAWA Satoru (00306135)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 遠藤仁司 (50221817)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 小池俊光 (40291629)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 善本知広 (60241171)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 安田好文 (50333539)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 杉山由希子 (70847384)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

Shibahara Hiroaki 柴原 浩章

柴原 浩章 シバハラ ヒロアキ

SHIBAHARA Hiroaki 柴原 浩章

Research Projects

Research Products

Co-Researchers

Development of a novel treatment for male infertility by using SerotoninPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of immunological onset mechanism of endometriosis and search for preventive/therapeutic techniques

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The class classification of anti-ZP antibodies in immunologic infetility women and application to infertility treatment

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The relationships of Chlamydia Trachomatis heaatshock protein 60 resulting in tubal damage

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of corresponding antigens against anti-sperm antibodies with the inhibitory effects on sperm motility and fertilization in infertile men.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

無精子症の発現に関する新しい候補遺伝子の解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of immunocontraceptive vaccine using GPI-anchored proteins on the surface of human spermPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

INVESTIGATION FOR IMMUNOGENETIC BACKGROUND OF ANTISPERM ANTIBODY,INVOLVEMENT OF HLA-II

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] V-20抗透明帯抗体.卵子学(編)2011

Author(s)

Publisher

Data Source

[Book] V-4受精と免疫(抗精子抗体、抗透明帯抗体).生命の誕生に向けて〈第二版〉.(編)2011

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[Book] Chlamydia trachomatisによる卵管性不妊モデルマウスの作製とその病態解明2009

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[Book] STDと不妊-クラミジア・トラコマティス感染症を中心に-2009

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[Book] ここが聞きたい不妊・不育診療ベストプラクティス2009

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[Journal Article] Infertility and Immunocontraception based on zona pellucida2014

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[Journal Article] Toward standardization of the cut-off value for the direct immunobead test using the postcoital test in immunologically infertile males.2013

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DOI

Shibahara Hiroaki 柴原浩章

柴原浩章シバハラヒロアキ

SHIBAHARA Hiroaki 柴原浩章