TSUTSUMI Hiroyuki 堤裕幸

… Alternative Names

堤裕幸ツツミヒロユキ

TSUTSUMI Hiroyukki 堤裕幸

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Researcher Number	80217348
Other IDs
External Links
Affiliation (Current)	2025: 札幌医科大学, 医学部, 名誉教授
Affiliation (based on the past Project Information) *help	2005 – 2013: 札幌医科大学, 医学部, 教授 2008: 札幌医科大学, 医学部, 講師 2001 – 2003: 札幌医科大学, 医学部, 教授 1999 – 2000: 札幌医科大学, 医学部, 講師 1992 – 1996: 札幌医科大学, 医学部, 講師 1990: 札幌医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Pediatrics / Pediatrics Except Principal Investigator Pediatrics / Pediatrics / Otorhinolaryngology
Keywords	Principal Investigator RSウイルス / 分子疫学 / RSV / herd immunity / Th2 / Th1 / RS virus / mRNA / IFN-γ / IL-12 … More / IL-6 / IL-4 / Allergy / Bronchial asthma / Infection / RSウイルスグループB / RSウイルスグループA / 小児アレルギー学 / 小児喘息 / 小児感染症学 / molecular epidemiology / RSV G protein / PcR-RFLP / gelatin allergy / gelatin / IL-2 / IL-13 / ゼラチンアレルギー / ゼラチン / IFN-alpha / TNF-alpha / IL-1beta / RS ウイルス / TNF-α / IL-1β / IgA antibody / Local immunity / Subgroup / TS virus / 局所免疫反応 / サブグループ / IgA抗体 / 局所免疫 / オブグループ / サイトメガロウイルス / 免疫不全 / UL97 / CMV / ガンシクロビル / UL97遺伝子 / ヒトサイトメガロウイルス / RSV細気管支炎 / IL4 / RSウイルス下気道炎 / TLR4 / 細気管支炎 … More Except Principal Investigator インターフェロン / 自然免疫 / RSウイルス / ウイルス / クルクミン / タイト結合 / 上皮細胞 / 鼻粘膜 / 免疫学 / 感染症 / Immunology / Infectious Diseases / Virus / cellular immunity / tumor necrosis factor-alpha / interferon-gamma / intracellular cytokines / cytomegalovirus(CMV) / 臨床分離株 / 特異的細胞性免疫能 / 細胞内サイトカイン / 特異的T細胞の活性化 / サイトメガロウイルス(CMV) / soluble interleukin 2 receptor (sIL-2R) / cytokine / T cell subsets / polymerase chain reaction (PCR) / human cytomegalovirus (HCMV) / CD_8陽性細胞 / 潜伏感染 / ヒトサイトメガロウイルス / サイトカイン / フローサイトメトリー / PCR法 / 再活性化 / 持続感染 / サイトメガロウイルス / ウイルス複製 / プロテアーゼ / ＲＳＶ / ウイルス受容体 / 遺伝子多型 / 上皮バリア / 鼻粘膜上皮 / フムロン / 細胞間接着装置 / 呼吸器ウイルス / 樹状細胞 / アレルギー / 抗ウイルス / Toll様受容体 / poly I:C / 抗ウイルス作用 / TLR3 / 2本鎖RNA / 小児感染症学 / 免疫抑制現象 / ムンプス特異的細胞性免疫反応 / 無菌性髄膜炎 / 麻疹・ムンプス・風疹(MMR)ワクチン Less

hTERT遺伝子導入ヒト鼻粘膜上皮を用いたRSウイルス感染症機序の解明Principal Investigator
- Principal Investigator
  
  堤裕幸
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Sapporo Medical University
Therapeutic approach using analysis of type III IFN SNPs in upper respiratory disease
- Principal Investigator
  
  HIMI Tetsuo
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Sapporo Medical University
Interaction between mucosal epithelium and immune system in human nasal mucosa.
- Principal Investigator
  
  HIMI Tetsuo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Sapporo Medical University
Elucidation of mediators which exert anti-respiratory syncytial virus activity reacted by double-stranded RNA
- Principal Investigator
  
  NAGAI Kazushige
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Sapporo Medical University
Genetic variability of human cytomegalovirus UL97 gene which associated with resistance to ganciclovirPrincipal Investigator
- Principal Investigator
  
  TSUTSUMI Hiroyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Sapporo Medical University
A study on host gene mutations associated with severity of RSV infectionPrincipal Investigator
- Principal Investigator
  
  TSUTSUMI Hiroyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Sapporo Medical University
Antiviral effect of double-stranded RNA on respiratory syncytial virus infection
- Principal Investigator
  
  NAGAI Kazushige
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Sapporo Medical University
The effect of RSV genotypes on the development of asthma after RSV lower respiratory tract infectionPrincipal Investigator
- Principal Investigator
  
  TSUTSUMI Hiroyuki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Sapporo Medical University
Analysis of Host Defense Mechanisms by Toll-like Receptor against Respiratory Syncytial Virus Infections
- Principal Investigator
  
  NAGAI Kazushige
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Sapporo Medical University
Cellular immunity of mother-to-infant infection and strain specificities of human cytomegalovirus strains obtained from
- Principal Investigator
  
  NUMAZAKI Kei
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Sapporo Medical University
Genetic variability of respiratory syncytial virus isolated during the last 20 years from SapporoPrincipal Investigator
- Principal Investigator
  
  TSUTSUMI Hiroyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Sapporo Medical University School of Medicine
The clarification of pathology of allergic Reactions to gelatin-containing vaccine.Principal Investigator
- Principal Investigator
  
  TSUTSUMI Hiroyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Sapporo Medical University
THE EFFECT OF INFLAMMATORY CYTOKINE AND APOPTOSIS ON PATHOGENESIS OF RSV INFECTION OF CHILDRENPrincipal Investigator
- Principal Investigator
  
  TSUTSUMI Hiroyuki
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE
Studies of latent infection and reactivation of human cytomegalovirus
- Principal Investigator
  
  NUMAZAKI Kei
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Sapporo Medical University
VIROLOGICAL AND EPIDEMIOLOGICAL STUDY OF RSV SUBGROUP INFECTIONPrincipal Investigator
- Principal Investigator
  
  TSUTSUMI Hiroyukki
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE
麻疹・ムンプス・風疹混合(MMR)ワクチン接種による無菌性髄膜炎患者の細胞性免疫機能の検討
- Principal Investigator
  
  山中樹
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Sapporo Medical University

All 2013 2012 2011 2008 2007 2006 2005

All Journal Article Presentation Book

[Book] モノクローナル抗体、KEY WORD感染症(第2版)2008
- Author(s)
  堤裕幸
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-19591258
[Book] 1呼吸器疾患気管支炎・肺炎、小児科診療ガイドライン2007
- Author(s)
  堤裕幸
- Publisher
  総合医学社
- Data Source
  KAKENHI-PROJECT-19591258
[Book] 第8章呼吸器疾患、小児科学・新生児学テキスト(第5版)2007
- Author(s)
  堤裕幸
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-19591258
[Book] III特殊な状況下の感染症、E胎児感染症、小児感染症学2007
- Author(s)
  堤裕幸
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-19591258
[Journal Article] ウイルス性上気道炎での免疫応答と鼻粘膜上皮の役割2013
- Author(s)
  氷見徹夫, 高野賢一, 大國毅, 小笠原徳子, 正木智之, 小幡和史, 堤裕幸, 小島隆, 澤田典均, 横田伸一
- Journal Title
  
  耳鼻咽喉科展望
  
  Volume: 56 Pages: 162-77
- NAID
  130004679511
- Data Source
  KAKENHI-PROJECT-23390398
[Journal Article] Humulone suppresses replication of RS virus and release of IL-8 and RANTES in normal human nasal epithelial cells2013
- Author(s)
  Fuchimoto J, Kojima T, Yokota SI, Himi T(全15名2. 14番)
- Journal Title
  
  Med Mol Morphol
  
  Volume: 46(4) Issue: 4 Pages: 203-9
- DOI
  10.1007/s00795-013-0024-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390398, KAKENHI-PROJECT-23590404, KAKENHI-PROJECT-23790507, KAKENHI-PROJECT-24659750
[Journal Article] Regulation of tight junctions in upper airway epithelium2013
- Author(s)
  Kojima T, Takano K, Himi T(全19名1, 3, 18番)
- Journal Title
  
  Biomed Res Int
  
  Volume: 2013 Pages: 947072-947072
- DOI
  10.1155/2013/947072
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390398, KAKENHI-PROJECT-23590404, KAKENHI-PROJECT-23791916, KAKENHI-PROJECT-24659750, KAKENHI-PROJECT-24791794, KAKENHI-PROJECT-25861573, KAKENHI-PROJECT-25861575
[Journal Article] Marked induction of MMP-10 by RS virus infection in human nasal epithelial cells2013
- Author(s)
  Hirakawa S, Kojima T, Yokota SI, Himi T,, (全15名5, 9番)
- Journal Title
  
  J Med Virol
  
  Volume: 85(12) Issue: 12 Pages: 2141-50
- DOI
  10.1002/jmv.23718
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390398, KAKENHI-PROJECT-23590404, KAKENHI-PROJECT-24659750
[Journal Article] Curcumin prevents replication of RS virus and the epithelial responses to it in human nasal epithelial cells2013
- Author(s)
  Obata K, Kojima T, Yokota S, Tsutsumi H, Himi T. (全15名2, 14番)
- Journal Title
  
  PLoS One
  
  Volume: 8(9) Issue: 9 Pages: 70225-70225
- DOI
  10.1371/journal.pone.0070225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390398, KAKENHI-PROJECT-23590404, KAKENHI-PROJECT-24659750, KAKENHI-PROJECT-24790355
[Journal Article] ウイルス性上気道炎での免疫応答と鼻粘膜上皮の役割2013
- Author(s)
  氷見徹夫,高野賢一,大國毅,小笠原徳子,正木智之,小幡和史,堤裕幸,小島隆,澤田典均,横田伸一
- Journal Title
  
  耳鼻咽喉科展望
  
  Volume: 56 Pages: 162-77
- NAID
  130004679511
- Data Source
  KAKENHI-PROJECT-24659750
[Journal Article] Phylogenetic and computational structural analysis of VP7 gene of group a human rotavirus G1P[8] strains obtained in Sapporo2012
- Author(s)
  Nagaoka Y, Tatsumi M, Tsugawa T, Yoto Y, Tsutsumi H
- Journal Title
  
  J Med Virol
  
  Volume: 84 Pages: 832-838
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591392
[Journal Article] Human cytomegalovirus UL97 D605E polymorphism has a high prevalence in immunocompetent Japanese infants and children2011
- Author(s)
  Tanaka K, Hori T, Yoto Y, Hatakeyama N, Yamamoto M, Suzuki N, Tsutsumi H
- Journal Title
  
  Microbiol Immunol
  
  Volume: 55 Pages: 328-330
- NAID
  10031121474
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591392
[Journal Article] 特集RSウイルス感染症2008
- Author(s)
  堤裕幸
- Journal Title
  
  病原微生物検出情報 29
  
  Pages: 271-274
- Data Source
  KAKENHI-PROJECT-19591258
[Journal Article] 小児疾患診療のための病態生理1、RSウイルス感染症2008
- Author(s)
  堤裕幸
- Journal Title
  
  小児内科 40
  
  Pages: 1168-1172
- Data Source
  KAKENHI-PROJECT-19591258
[Journal Article] Soluble G protein of respiratory syncytial virus inhibit Toll-like receptor 3/4 mediated IFN-beta induction2008
- Author(s)
  Shingai M, Azuma M, Ebihara T, Sasai M, Funami K, Ayata M, Ogura H, Tsutsumi H, Matsumoto M, Seya T.
- Journal Title
  
  Int Immunol 42
  
  Pages: 374-380
- NAID
  10022599455
- Data Source
  KAKENHI-PROJECT-19591258
[Journal Article] 第39回日本小児感染症学会教育講演3、RSウイルス感染症と喘鳴・喘息2008
- Author(s)
  堤裕幸
- Journal Title
  
  小児感染免疫 20
  
  Pages: 206-212
- Data Source
  KAKENHI-PROJECT-19591258
[Journal Article] Quantification of BK polyoma viruria in Japanese children and adults with hemorrhagic cystitis complication stem cell transplantation2008
- Author(s)
  Tanaka K, Hori T, Hatakeyama N, Yamamoto M, Takayama R, Yoto Y, Suzuki N, Hayashi T Ikeda Y, Ikeda H, Ishida T, Tsutsumi H.
- Journal Title
  
  J Med Virol 80
  
  Pages: 2108-2112
- Data Source
  KAKENHI-PROJECT-19591258
[Journal Article] 特集小児ウイルス感染症の現状、序-今、小児ウイルス感染症では何が問題か? 何が話題か?2008
- Author(s)
  堤裕幸
- Journal Title
  
  化学療法の領域 24
  
  Pages: 18-19
- Data Source
  KAKENHI-PROJECT-19591258
[Journal Article] 特集 : 冬のウイルス感染症、IIRSウイルス感染症、RSウイルス感染症総論2007
- Author(s)
  永井和重、堤裕幸
- Journal Title
  
  小児科診療 70
  
  Pages: 2237-2241
- Data Source
  KAKENHI-PROJECT-19591258
[Journal Article] RSウイルスと気道疾患2007
- Author(s)
  堤裕幸
- Journal Title
  
  アレルギー 56
  
  Pages: 1493-1497
- NAID
  110006547228
- Data Source
  KAKENHI-PROJECT-19591258
[Journal Article] 新感染症学感染症学各論 RSウイルス感染症2007
- Author(s)
  堤裕幸
- Journal Title
  
  日本臨床 65
  
  Pages: 384-388
- Data Source
  KAKENHI-PROJECT-17591101
[Journal Article] RSウイルス感染症-最近のトピックスも含めて-2007
- Author(s)
  堤裕幸
- Journal Title
  
  感染と抗菌薬 10
  
  Pages: 301-307
- NAID
  40015642287
- Data Source
  KAKENHI-PROJECT-19591258
[Journal Article] RSウイルス感染症総論2007
- Author(s)
  永井和重、堤裕幸
- Journal Title
  
  小児科診療 70巻
  
  Pages: 2237-224
- Data Source
  KAKENHI-PROJECT-19591259
[Journal Article] RSウイルス感染症2007
- Author(s)
  堤裕幸
- Journal Title
  
  Sysmex Journal Web 8
  
  Pages: 1-12
- NAID
  10016929144
- Data Source
  KAKENHI-PROJECT-19591258
[Journal Article] RSウイルス感染症、新感染症学(下)2007
- Author(s)
  堤裕幸
- Journal Title
  
  日本臨床 65
  
  Pages: 384-388
- Data Source
  KAKENHI-PROJECT-19591258
[Journal Article] 風邪の全体像2006
- Author(s)
  堤裕幸
- Journal Title
  
  臨床とウイルス 34(5)
  
  Pages: 391-395
- NAID
  10018717677
- Data Source
  KAKENHI-PROJECT-17591101
[Journal Article] 臨床 RSウイルス感染症2006
- Author(s)
  堤裕幸
- Journal Title
  
  呼吸 25(11)
  
  Pages: 1034-1038
- Data Source
  KAKENHI-PROJECT-17591101
[Journal Article] RSウイルス感染症と気道疾患について2006
- Author(s)
  堤裕幸
- Journal Title
  
  アレルギー・免疫 13(7)
  
  Pages: 77-78
- Data Source
  KAKENHI-PROJECT-17591101
[Journal Article] A phylogenetic study of human respiratory syncytial viruses Group A and B strains isolated in two cities in Japan from 1980-2002.2005
- Author(s)
  Kuroiwa Y, Nagai K, Okita L, Yui I, Kase T, Nakayama T, Tsutsumi H.
- Journal Title
  
  J Med Virol 76
  
  Pages: 241-247
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591101
[Presentation] 教育講演RSウイルス感染症の疫学と病態2008
- Author(s)
  堤裕幸
- Organizer
  第41回日本小児呼吸器疾患学会
- Place of Presentation
  函館
- Year and Date
  2008-10-03
- Data Source
  KAKENHI-PROJECT-19591258
[Presentation] 会頭講演感染免疫から見た親と子、そして社会の絆2008
- Author(s)
  堤裕幸
- Organizer
  第55回日本児保健学会
- Place of Presentation
  札幌
- Year and Date
  2008-09-25
- Data Source
  KAKENHI-PROJECT-19591258
[Presentation] RSウイルス感染に対するTLR3の感染防御作用2008
- Author(s)
  渡辺一人、永井和重、堤裕幸
- Organizer
  第40回日本小児感染症学会総会学術集会
- Place of Presentation
  名古屋市
- Year and Date
  2008-11-15
- Data Source
  KAKENHI-PROJECT-19591259
[Presentation] 招請講演RSウイルスと気道疾患2007
- Author(s)
  堤裕幸
- Organizer
  第19回日本アレルギー学会春季臨床大会
- Place of Presentation
  横浜
- Year and Date
  2007-06-10
- Data Source
  KAKENHI-PROJECT-19591258
[Presentation] 教育講演小児ウイルス性呼吸器感染症の最近の話題2007
- Author(s)
  堤裕幸
- Organizer
  第81回日本感染症学会
- Place of Presentation
  京都
- Year and Date
  2007-04-10
- Data Source
  KAKENHI-PROJECT-19591258

1. NAGAI Kazushige (50347168)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
2. NUMAZAKI Kei (00228272)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. HONMA Shinjiro (00404658)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. HIMI Tetsuo (90181114)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. KOJIMA Takashi (30260764)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
6. OIKAWA Takumi (70574739)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YOTO Yuko (10404659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. HORI Tsukasa (20398324)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. TAKANO Kenichi (70404689)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. OHKUNI Tsuyoshi (40464490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. SEKI Nobuhiko (30404693)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. WAKAI Shuji (30230907)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 山中樹 (70045508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TSUTSUMI Hiroyuki 堤 裕幸

堤 裕幸 ツツミ ヒロユキ

TSUTSUMI Hiroyukki 堤 裕幸

Research Projects

Research Products

Co-Researchers

hTERT遺伝子導入ヒト鼻粘膜上皮を用いたRSウイルス感染症機序の解明Principal Investigator

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Genetic variability of human cytomegalovirus UL97 gene which associated with resistance to ganciclovirPrincipal Investigator

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A study on host gene mutations associated with severity of RSV infectionPrincipal Investigator

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Principal Investigator

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The effect of RSV genotypes on the development of asthma after RSV lower respiratory tract infectionPrincipal Investigator

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Principal Investigator

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Genetic variability of respiratory syncytial virus isolated during the last 20 years from SapporoPrincipal Investigator

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The clarification of pathology of allergic Reactions to gelatin-containing vaccine.Principal Investigator

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Project Period (FY)

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THE EFFECT OF INFLAMMATORY CYTOKINE AND APOPTOSIS ON PATHOGENESIS OF RSV INFECTION OF CHILDRENPrincipal Investigator

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TSUTSUMI Hiroyuki 堤裕幸

堤裕幸ツツミヒロユキ

TSUTSUMI Hiroyukki 堤裕幸