HITOTSUYANAGI Yukio 一柳幸生

… Alternative Names

一柳幸生ヒトツヤナギユキオ

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Researcher Number	80218726
Other IDs	https://orcid.org/0000-0003-0017-4951
External Links
Affiliation (based on the past Project Information) *help	2018 – 2022: 東京薬科大学, 薬学部, 教授 2016 – 2017: 東京薬科大学, 薬学部, 准教授 2012 – 2014: 東京薬科大学, 薬学部, 准教授 2007: Tokyo University of Pharmacy and Life Science, School of Pharmacy, Associate Professor 2004 – 2006: 東京薬科大学, 薬学部, 助教授 … More 2000: Tokyo Uni.of Pharm. & Life Sci., Pharm., Associate Prof., 薬学部, 助教授 1994 – 1999: 東京薬科大学, 薬学部, 講師 1992 – 1993: 東京薬科大学, 薬学部, 助手 1991: 東京薬科大学, 助手 1989: 東京薬科大学, 助手 Less
Review Section/Research Field	Principal Investigator Chemical pharmacy / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Natural medicines Except Principal Investigator Chemical pharmacy
Keywords	Principal Investigator RA-VII / Rubia cordifolia / Rubia / ペプチド / 細胞毒性 / 化合物ライブラリー / RA-III / アナログ / カッシノイド / アルカロイド … More / Stemona / 配座解析 / 環状ペプチド / フッ素化天然有機化合物 / Brucea javanica / ブルセオシド A / フッ化アナログ / シノコクリン / ブルサトール / 細胞毒活性 / フェニルプロパノイド / デオキシボウバルジン / 天然有機化合物 / フッ素化 / VCDスペクトル / アゼピンアルカロイド / 配座探索 / DFT / ステモナアルカロイド / 中分子 / 密度汎関数法 / Ｎ－オキシド / VCD / Stemona tuberosa / 密度汎関数理論 / 化合物ライブラリ / 赤外円二色性スペクトル / akane / conformer / analogue / cytotoxicity / cycloisodityrosne / peptide / NMR / 茜草根 / RA-XVII / N,N-ジメチルシクロイソジチロシン / bouvardin / RA-XVIII / RA-II / X線結晶解析 / deoxybouvardin / アカネ / 配座異性体 / シクロイソジチロシン / 構造決定 / Eurycoma / ペプチド合成 / アナログデザイン / アクチン / 抗腫瘍活性 … More Except Principal Investigator 構造活性相関 / 茜草根 / 抗腫瘍活性物質 / Rubia cordifolia / 環状ペプチド / conformation analysis / cyclic peptide / antitumor activity / コンホメーション解析 / 抗腫瘍活性 / 生理活性物質 / Maytenus / Cissampelos / Abuta / Eurycoma / 環状ヘキサペプチド / 抗腫瘍活性スクリーニング / Linum / Vaccaris / fixation of cis configuration / Rubiae Radix / Linum usitatissimum / Vaccaria segetalis / Rubia akane / Annona squamosa / Citrus / Linum usitatissium / シス固定化 / structure elucidation / biological substance / structure-activity relationship / higher plant / oligopeptide / 構造鮮析 / 構造解析 / 高等植物 / オリゴペプチド / Quassinoid / Tropone / Cytotoxic substance / Antitumor substance / triterpene / quassinoid / Eurycoma longifolia / アザフルオランセンアルカロイド / トロポロイソキノリンアルカロイド / Cissampelos pareira / Abuta concolor / 細胞毒性物質 / トリテルペン / トロポロン / Msayenus / Ailanthus / カッシノイド / トロポン / 細胞毒活性物質 / RA-VII / 抗腫瘍活性スクリ-ニング / RAーVII / コンホメ-ション解析 / RAー700 Less

Fluorinated Natural Products LibraryPrincipal Investigator
- Principal Investigator
  
  Hitotsuyanagi Yukio
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Construction of a natural product library composed of azepine alkaloids and determination of their absolute configuration by VCD spectroscopy.Principal Investigator
- Principal Investigator
  
  HITOTSUYANAGI Yukio
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Natural medicines
- Research Institution
  Tokyo University of Pharmacy and Life Science
Exploration of the pharmacophore of antitumor peptide RA-VII that interacts with actinPrincipal Investigator
- Principal Investigator
  
  HITOTSUYANAGI Yukio
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Identification of the structural requirements of RA-series peptides for expressing antitumor activity useful for designing novel antitumor drugs.Principal Investigator
- Principal Investigator
  
  HITOTSUYANAGI Yukio
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Development Research for Bio-active Cyclic Peptides from Plant Sources
- Principal Investigator
  
  TAKEYA Koichi
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo University of Pharmacy & Life Science
Studies on Antitumor Cyclic Oligopeptides from Higher Plants
- Principal Investigator
  
  ITOKAWA Hideji
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo University of Pharmacy & Life Science
Studies on Tropical Medicinal Plants
- Principal Investigator
  
  TAKEYA Koichi
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo University of Pharmacy & Life Science
抗腫瘍活性オリゴペプチド構成アミノ酸の立体的差異による活性差について
- Principal Investigator
  
  糸川秀治
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tokyo University of Pharmacy and Life Science
抗腫瘍活性オリゴペプチド構成アミノ酸の立体的差異による活性差について
- Principal Investigator
  
  糸川秀治
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tokyo University of Pharmacy and Life Science
抗がん性環状ペプチドの構造活性相関
- Principal Investigator
  
  ITOKAWA Hideji
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tokyo University of Pharmacy and Life Science

All 2023 2019 2016 2013 2008 2007 2004

All Journal Article Presentation

[Journal Article] Bridged Peptide Analogue of RA-VII, an Antitumor Bicyclic Hexapeptide2023
- Author(s)
  Hitotsuyanagi, Yukio; Hinosawa, Taka-aki; Nakagawa, Yoshie; Ito, Sho; Lee, Ji-Ean; Hasuda, Tomoyo
- Journal Title
  
  Synlett
  
  Volume: 34 Issue: 02 Pages: 183-187
- DOI
  10.1055/a-1960-4340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07141
[Journal Article] RA-XXV and RA-XXVI, bicyclic hexapeptides from Rubia cordifolia L.: Structure, synthesis, and conformation2019
- Author(s)
  Hitotsuyanagi, Yukio; Hirai, Masahito; Odagiri, Masumi; Komine, Miho; Hasuda, Tomoyo; Fukaya, Haruhiko; Takeya, Koichi
- Journal Title
  
  Chemistry - An Asian Journal
  
  Volume: 14 Issue: 1 Pages: 205-215
- DOI
  10.1002/asia.201801466
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08308
[Journal Article] Stemona-amines F and G, new alkaloids from Stemona tuberosa2016
- Author(s)
  Yukio Hitotsuyanagi, Yoshiyuki Sekiya, Haruhiko Fukaya, Hyun Sun Park, Shu Zhu, Katsuko Komatsu
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 57 Issue: 51 Pages: 5746-5749
- DOI
  10.1016/j.tetlet.2016.10.096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08308
[Journal Article] Absolute Structures of Stemona-Lactam S and Tuberostemospiroline, Alkaloids from <i>Stemona tuberosa</i>2013
- Author(s)
  Haruhiko Fukaya, Yukio Hitotsuyanagi, Yutaka Aoyagi, Zhu Shu, Katsuko Komatsu, and Koichi Takeya
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 61 Issue: 10 Pages: 1085-1089
- DOI
  10.1248/cpb.c13-00454
- NAID
  130004137249
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590024
[Journal Article] Structures of Stemona-amine B and Stemona-lactams M-R2013
- Author(s)
  Yukio Hitotsuyanagi, Haruhiko Fukaya, Erika Takeda, Shoko Matsuda, Yuka Saishu, Shu Zhu, Katsuko Komatsu, and Koichi Takeya
- Journal Title
  
  Tetrahedron
  
  Volume: 69 Issue: 30 Pages: 62976304-62976304
- DOI
  10.1016/j.tet.2013.04.136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590024
[Journal Article] Stemona-amines C-E, New Alkaloids from Stemona tuberosa2013
- Author(s)
  Yukio Hitotsuyanagi, Genta Shigemori, Haruhiko Fukaya, Maho Hikita, Shu Zhu, Katsuko Komatsu, and Koichi Takeya
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 54 Issue: 51 Pages: 69956998-69956998
- DOI
  10.1016/j.tetlet.2013.10.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590024
[Journal Article] Aza-cycloisodityrosine Analogue of RA-VII, an Antitumor Bicyclic Hexapeptide2013
- Author(s)
  Yukio Hitotsuyanagi, Akihiro Miyazawa, Taka-aki Hinosawa, Yoshie Nakagawa, Tomoyo Hasuda, and Koichi Takeya
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 23 Issue: 24 Pages: 67286731-67286731
- DOI
  10.1016/j.bmcl.2013.10.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590024
[Journal Article] A novel bicyclic hexapeptide, RA-XVIII, from Rubia cordifolia: Structure, semi-synthesis, and cytotoxicity2008
- Author(s)
  Ji-Ean Lee, Yukio Hitotsuyanagi, Ik-Hwi Kim, Tomoyo Hasuda, and Koichi Takeya
- Journal Title
  
  Bioorg. Med. Chem. Lett. 18
  
  Pages: 808-811
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590015
[Journal Article] New Cytotoxic Bicyclic Hexapeptides, RA-XXIII and RA-XXIV, from Rubia cordifolia L..2008
- Author(s)
  Ji-Ean Lee, Yukio Hitotsuyanagi, Haruhiko Fukaya, Kazuyuki Kondo, and Koichi Takeya
- Journal Title
  
  Chem. Pharm. Bull. 56(印刷中)
- NAID
  110006664003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590015
[Journal Article] Structures of cytotoxic bicyclic hexapeptides, RA-XIX, -XX, -XXI, and -XXII, from Rubia cordifolia L.2008
- Author(s)
  Ji-Ean Lee, Yukio Hitotsuyanagi, and Koichi Takeya
- Journal Title
  
  Terahedron 64(印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590015
[Journal Article] Isolation, structural elucidation, and synthesis of RA-XVII, a novel bicyclic hexapeptide from Rubia cordifolia, and the effect of side chain at residue 1 upon the conformation and cytotoxic activity.2004
- Author(s)
  Yukio Hitotsuyanagi
- Journal Title
  
  Tetrahedron Letters 45・5
  
  Pages: 935-938
- Data Source
  KAKENHI-PROJECT-16590015
[Journal Article] Synthesis of [Gly-1]RA-VII, [Gly-2]RA-VII, and [Gly-4]RA-VII. Glycine-Containing Analogues of RA-VII, an Antitumor Bicyclic Hexapeptide from Rubia Plants.2004
- Author(s)
  Yukio Hitotsuyanagi
- Journal Title
  
  The Journal of Organic Chemistry 69・5
  
  Pages: 1481-1486
- Data Source
  KAKENHI-PROJECT-16590015
[Journal Article] チオアミドを利用した抗腫瘍性環状ペプチド:RA-VIIの化学修飾と配座構造-活性相関の解明2004
- Author(s)
  一柳幸生
- Journal Title
  
  有機合成化学協会誌 62・10
  
  Pages: 993-1005
- NAID
  10013652543
- Data Source
  KAKENHI-PROJECT-16590015
[Journal Article] Synthesis of [Gly-1]RA-VII, [Gly-2]RA-VII, and [Gly-4]RA-VII. Glycine-containing analogues of RA-VII, an antitumor bicyclic hexapeptide from Rubia plants2004
- Author(s)
  Yukio, Hitotsuyanagi, et. al.
- Journal Title
  
  J. Org. Chem 69
  
  Pages: 1481-1486
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590015
[Journal Article] Synthesis of[gly-1]RA-VII, [Gly-2]RA-VII, and[Gly-4]RA-VII. Glycine-containing analogues of RA-VII, an antitumor bicyclic hexapeptide from Rubia plants2004
- Author(s)
  Yukio Hitotsuyanagi
- Journal Title
  
  J.Org.Chem. 69
  
  Pages: 1481-1486
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590015
[Journal Article] Chemical modification via thioamide intermediates and conformation-activity relationships of an antitumor bicyclic hexapeptide RA-VII2004
- Author(s)
  Yukio, Hitotsuyanagi, et. al.
- Journal Title
  
  Yuki Gosei Kagaku Kyokaishi 62
  
  Pages: 933-1005
- NAID
  10013652543
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590015
[Journal Article] Isolation, structural elucidation, and synthesis of RA-XVII, a novel bicyclic hexapeptide from Rubia cordifolia, and the effect of side chain at residue 1 upon the conformation and cytotoxic activity2004
- Author(s)
  Yukio Hitotsuyanagi
- Journal Title
  
  Tetrahedron Lett. 45
  
  Pages: 935-938
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590015
[Journal Article] Isolation, structural elucidation, and synthesis of RA-XVII, a novel bicyclic hexapeptide from Rubia cordifolia, and the effect of side chain at residue 1 upon the conformation and cytotoxic activity2004
- Author(s)
  Yukio, Hitotsuyanagi, et. al.
- Journal Title
  
  Tetrahedron Lett 45
  
  Pages: 935-938
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590015
[Journal Article] チオアミドを利用した抗腫瘍性環状ペプチドRA-VIIの化学修飾と配座構造一活性相関の解明2004
- Author(s)
  一柳幸生
- Journal Title
  
  有機合成化学協会誌 62
  
  Pages: 993-1005
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590015
[Presentation] Rubia cordifoliaより得られた新規環状ペプチドRA-XIX, -XX, -XXI及び-XXIIについて2008
- Author(s)
  李知彦, 一柳幸生, 竹谷孝一
- Organizer
  日本薬学会第128年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-16590015
[Presentation] 抗腫瘍性環状ペプチドRA-VIIの芳香環部位の構造活性について2007
- Author(s)
  李知彦, 一柳幸生, 竹谷孝一
- Organizer
  第五回次世代を担う有機化学シンポジウム
- Place of Presentation
  日本薬学会長井記念ホール
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-16590015

1. TAKEYA Koichi (20120149)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. ITOKAWA Hideji (60057304)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. MORITA Hiroshi (70220069)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. 塚越茂 (60085644)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. FUKAYA Haruhiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

HITOTSUYANAGI Yukio 一柳 幸生

一柳 幸生 ヒトツヤナギ ユキオ

Research Projects

Research Products

Co-Researchers

Fluorinated Natural Products LibraryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Construction of a natural product library composed of azepine alkaloids and determination of their absolute configuration by VCD spectroscopy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploration of the pharmacophore of antitumor peptide RA-VII that interacts with actinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of the structural requirements of RA-series peptides for expressing antitumor activity useful for designing novel antitumor drugs.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development Research for Bio-active Cyclic Peptides from Plant Sources

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on Antitumor Cyclic Oligopeptides from Higher Plants

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on Tropical Medicinal Plants

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

抗腫瘍活性オリゴペプチド構成アミノ酸の立体的差異による活性差について

Principal Investigator

Project Period (FY)

Research Category

Research Institution

抗腫瘍活性オリゴペプチド構成アミノ酸の立体的差異による活性差について

Principal Investigator

Project Period (FY)

Research Category

Research Institution

抗がん性環状ペプチドの構造活性相関

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Journal Article] Bridged Peptide Analogue of RA-VII, an Antitumor Bicyclic Hexapeptide2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RA-XXV and RA-XXVI, bicyclic hexapeptides from Rubia cordifolia L.: Structure, synthesis, and conformation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stemona-amines F and G, new alkaloids from Stemona tuberosa2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Absolute Structures of Stemona-Lactam S and Tuberostemospiroline, Alkaloids from <i>Stemona tuberosa</i>2013

Author(s)

Journal Title

HITOTSUYANAGI Yukio 一柳幸生

一柳幸生ヒトツヤナギユキオ