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HITOTSUYANAGI Yukio  一柳 幸生

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… Alternative Names

一柳 幸生  ヒトツヤナギ ユキオ

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Researcher Number 80218726
External Links
Affiliation (Current) 2022: 東京薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help 2018 – 2020: 東京薬科大学, 薬学部, 教授
2016 – 2017: 東京薬科大学, 薬学部, 准教授
2012 – 2014: 東京薬科大学, 薬学部, 准教授
2007: Tokyo University of Pharmacy and Life Science, School of Pharmacy, Associate Professor
2004 – 2006: 東京薬科大学, 薬学部, 助教授 … More
2000: Tokyo Uni.of Pharm. & Life Sci., Pharm., Associate Prof., 薬学部, 助教授
1994 – 1999: 東京薬科大学, 薬学部, 講師
1992 – 1993: 東京薬科大学, 薬学部, 助手
1991: 東京薬科大学, 助手
1989: 東京薬科大学, 助手 Less
Review Section/Research Field
Principal Investigator
Chemical pharmacy / Natural medicines / Basic Section 47050:Environmental and natural pharmaceutical resources-related
Except Principal Investigator
Chemical pharmacy
Keywords
Principal Investigator
RA-VII / 細胞毒性 / ペプチド / Rubia / Rubia cordifolia / 環状ペプチド / 配座解析 / Stemona / アルカロイド / カッシノイド … More / アナログ / 化合物ライブラリー / 抗腫瘍活性 / アクチン / アナログデザイン / ペプチド合成 / Eurycoma / 構造決定 / シクロイソジチロシン / 配座異性体 / アカネ / deoxybouvardin / X線結晶解析 / RA-II / RA-III / RA-XVIII / bouvardin / N,N-ジメチルシクロイソジチロシン / RA-XVII / 茜草根 / NMR / peptide / cycloisodityrosne / cytotoxicity / analogue / conformer / akane / 赤外円二色性スペク トル / 化合物ライブラリ / 密度汎関数理論 / Stemona tuberosa / VCD / N-オキシド / 密度汎関数法 / 中分子 / ステモナアルカロイド / DFT / 配座探索 / アゼピンアルカロイド / VCDスペクトル / ブルサトール / デオキシボウバルジン / フッ化アナログ / ブルセオシド A / Brucea javanica / フッ素化天然有機化合物 … More
Except Principal Investigator
構造活性相関 / 抗腫瘍活性物質 / 茜草根 / 環状ペプチド / Rubia cordifolia / 抗腫瘍活性スクリーニング / 環状ヘキサペプチド / Eurycoma / Abuta / Cissampelos / Maytenus / 生理活性物質 / 抗腫瘍活性 / コンホメーション解析 / antitumor activity / cyclic peptide / conformation analysis / RAー700 / コンホメ-ション解析 / RAーVII / 抗腫瘍活性スクリ-ニング / RA-VII / 細胞毒活性物質 / トロポン / カッシノイド / Ailanthus / Msayenus / トロポロン / トリテルペン / 細胞毒性物質 / Abuta concolor / Cissampelos pareira / トロポロイソキノリンアルカロイド / アザフルオランセンアルカロイド / Eurycoma longifolia / quassinoid / triterpene / Antitumor substance / Cytotoxic substance / Tropone / Quassinoid / オリゴペプチド / 高等植物 / 構造解析 / 構造鮮析 / oligopeptide / higher plant / structure-activity relationship / biological substance / structure elucidation / シス固定化 / Linum usitatissium / Citrus / Annona squamosa / Rubia akane / Vaccaria segetalis / Linum usitatissimum / Rubiae Radix / fixation of cis configuration / Vaccaris / Linum Less
  • Research Projects

    (10 results)
  • Research Products

    (20 results)
  • Co-Researchers

    (5 People)
  •  次世代天然物ライブラリー構築を指向した生物活性フッ素化天然有機化合物Principal Investigator

    • Principal Investigator
      一柳 幸生
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47050:Environmental and natural pharmaceutical resources-related
    • Research Institution
      Tokyo University of Pharmacy and Life Science
  •  Construction of a natural product library composed of azepine alkaloids and determination of their absolute configuration by VCD spectroscopy.Principal Investigator

    • Principal Investigator
      HITOTSUYANAGI Yukio
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Natural medicines
    • Research Institution
      Tokyo University of Pharmacy and Life Science
  •  Exploration of the pharmacophore of antitumor peptide RA-VII that interacts with actinPrincipal Investigator

    • Principal Investigator
      HITOTSUYANAGI Yukio
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Tokyo University of Pharmacy and Life Science
  •  Identification of the structural requirements of RA-series peptides for expressing antitumor activity useful for designing novel antitumor drugs.Principal Investigator

    • Principal Investigator
      HITOTSUYANAGI Yukio
    • Project Period (FY)
      2004 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Tokyo University of Pharmacy and Life Science
  •  Development Research for Bio-active Cyclic Peptides from Plant Sources

    • Principal Investigator
      TAKEYA Koichi
    • Project Period (FY)
      1997 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Chemical pharmacy
    • Research Institution
      Tokyo University of Pharmacy & Life Science
  •  Studies on Antitumor Cyclic Oligopeptides from Higher Plants

    • Principal Investigator
      ITOKAWA Hideji
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Tokyo University of Pharmacy & Life Science
  •  Studies on Tropical Medicinal Plants

    • Principal Investigator
      TAKEYA Koichi
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Tokyo University of Pharmacy & Life Science
  •  抗腫瘍活性オリゴペプチド構成アミノ酸の立体的差異による活性差について

    • Principal Investigator
      糸川 秀治
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tokyo University of Pharmacy and Life Science
  •  抗腫瘍活性オリゴペプチド構成アミノ酸の立体的差異による活性差について

    • Principal Investigator
      糸川 秀治
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tokyo University of Pharmacy and Life Science
  •  抗がん性環状ペプチドの構造活性相関

    • Principal Investigator
      ITOKAWA Hideji
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tokyo University of Pharmacy and Life Science

All 2019 2016 2013 2008 2007 2004

All Journal Article Presentation

  • [Journal Article] RA-XXV and RA-XXVI, bicyclic hexapeptides from Rubia cordifolia L.: Structure, synthesis, and conformation2019

    • Author(s)
      Hitotsuyanagi, Yukio; Hirai, Masahito; Odagiri, Masumi; Komine, Miho; Hasuda, Tomoyo; Fukaya, Haruhiko; Takeya, Koichi
    • Journal Title

      Chemistry - An Asian Journal

      Volume: 14 Pages: 205-215

    • DOI

      10.1002/asia.201801466

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08308
  • [Journal Article] Stemona-amines F and G, new alkaloids from Stemona tuberosa2016

    • Author(s)
      Yukio Hitotsuyanagi, Yoshiyuki Sekiya, Haruhiko Fukaya, Hyun Sun Park, Shu Zhu, Katsuko Komatsu
    • Journal Title

      Tetrahedron Letters

      Volume: 57 Pages: 5746-5749

    • DOI

      10.1016/j.tetlet.2016.10.096

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08308
  • [Journal Article] Absolute Structures of Stemona-Lactam S and Tuberostemospiroline, Alkaloids from <i>Stemona tuberosa</i>2013

    • Author(s)
      Haruhiko Fukaya, Yukio Hitotsuyanagi, Yutaka Aoyagi, Zhu Shu, Katsuko Komatsu, and Koichi Takeya
    • Journal Title

      CHEMICAL & PHARMACEUTICAL BULLETIN

      Volume: 61 Issue: 10 Pages: 10851089-10851089

    • DOI

      10.1248/cpb.c13-00454

    • NAID

      130004137249

    • ISSN
      0009-2363, 1347-5223
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590024
  • [Journal Article] Structures of Stemona-amine B and Stemona-lactams M-R2013

    • Author(s)
      Yukio Hitotsuyanagi, Haruhiko Fukaya, Erika Takeda, Shoko Matsuda, Yuka Saishu, Shu Zhu, Katsuko Komatsu, and Koichi Takeya
    • Journal Title

      Tetrahedron

      Volume: 69 Pages: 62976304-62976304

    • DOI

      10.1016/j.tet.2013.04.136

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590024
  • [Journal Article] Stemona-amines C-E, New Alkaloids from Stemona tuberosa2013

    • Author(s)
      Yukio Hitotsuyanagi, Genta Shigemori, Haruhiko Fukaya, Maho Hikita, Shu Zhu, Katsuko Komatsu, and Koichi Takeya
    • Journal Title

      Tetrahedron Lett.

      Volume: 54 Pages: 69956998-69956998

    • DOI

      10.1016/j.tetlet.2013.10.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590024
  • [Journal Article] Aza-cycloisodityrosine Analogue of RA-VII, an Antitumor Bicyclic Hexapeptide2013

    • Author(s)
      Yukio Hitotsuyanagi, Akihiro Miyazawa, Taka-aki Hinosawa, Yoshie Nakagawa, Tomoyo Hasuda, and Koichi Takeya
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 23 Pages: 67286731-67286731

    • DOI

      10.1016/j.bmcl.2013.10.033

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590024
  • [Journal Article] A novel bicyclic hexapeptide, RA-XVIII, from Rubia cordifolia: Structure, semi-synthesis, and cytotoxicity2008

    • Author(s)
      Ji-Ean Lee, Yukio Hitotsuyanagi, Ik-Hwi Kim, Tomoyo Hasuda, and Koichi Takeya
    • Journal Title

      Bioorg. Med. Chem. Lett. 18

      Pages: 808-811

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16590015
  • [Journal Article] New Cytotoxic Bicyclic Hexapeptides, RA-XXIII and RA-XXIV, from Rubia cordifolia L..2008

    • Author(s)
      Ji-Ean Lee, Yukio Hitotsuyanagi, Haruhiko Fukaya, Kazuyuki Kondo, and Koichi Takeya
    • Journal Title

      Chem. Pharm. Bull. 56(印刷中)

    • NAID

      110006664003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16590015
  • [Journal Article] Structures of cytotoxic bicyclic hexapeptides, RA-XIX, -XX, -XXI, and -XXII, from Rubia cordifolia L.2008

    • Author(s)
      Ji-Ean Lee, Yukio Hitotsuyanagi, and Koichi Takeya
    • Journal Title

      Terahedron 64(印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16590015
  • [Journal Article] Isolation, structural elucidation, and synthesis of RA-XVII, a novel bicyclic hexapeptide from Rubia cordifolia, and the effect of side chain at residue 1 upon the conformation and cytotoxic activity.2004

    • Author(s)
      Yukio Hitotsuyanagi
    • Journal Title

      Tetrahedron Letters 45・5

      Pages: 935-938

    • Data Source
      KAKENHI-PROJECT-16590015
  • [Journal Article] Synthesis of [Gly-1]RA-VII, [Gly-2]RA-VII, and [Gly-4]RA-VII. Glycine-Containing Analogues of RA-VII, an Antitumor Bicyclic Hexapeptide from Rubia Plants.2004

    • Author(s)
      Yukio Hitotsuyanagi
    • Journal Title

      The Journal of Organic Chemistry 69・5

      Pages: 1481-1486

    • Data Source
      KAKENHI-PROJECT-16590015
  • [Journal Article] チオアミドを利用した抗腫瘍性環状ペプチド:RA-VIIの化学修飾と配座構造-活性相関の解明2004

    • Author(s)
      一柳 幸生
    • Journal Title

      有機合成化学協会誌 62・10

      Pages: 993-1005

    • NAID

      10013652543

    • Data Source
      KAKENHI-PROJECT-16590015
  • [Journal Article] Synthesis of [Gly-1]RA-VII, [Gly-2]RA-VII, and [Gly-4]RA-VII. Glycine-containing analogues of RA-VII, an antitumor bicyclic hexapeptide from Rubia plants2004

    • Author(s)
      Yukio, Hitotsuyanagi, et. al.
    • Journal Title

      J. Org. Chem 69

      Pages: 1481-1486

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590015
  • [Journal Article] Synthesis of[gly-1]RA-VII, [Gly-2]RA-VII, and[Gly-4]RA-VII. Glycine-containing analogues of RA-VII, an antitumor bicyclic hexapeptide from Rubia plants2004

    • Author(s)
      Yukio Hitotsuyanagi
    • Journal Title

      J.Org.Chem. 69

      Pages: 1481-1486

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16590015
  • [Journal Article] Chemical modification via thioamide intermediates and conformation-activity relationships of an antitumor bicyclic hexapeptide RA-VII2004

    • Author(s)
      Yukio, Hitotsuyanagi, et. al.
    • Journal Title

      Yuki Gosei Kagaku Kyokaishi 62

      Pages: 933-1005

    • NAID

      10013652543

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590015
  • [Journal Article] Isolation, structural elucidation, and synthesis of RA-XVII, a novel bicyclic hexapeptide from Rubia cordifolia, and the effect of side chain at residue 1 upon the conformation and cytotoxic activity2004

    • Author(s)
      Yukio Hitotsuyanagi
    • Journal Title

      Tetrahedron Lett. 45

      Pages: 935-938

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16590015
  • [Journal Article] Isolation, structural elucidation, and synthesis of RA-XVII, a novel bicyclic hexapeptide from Rubia cordifolia, and the effect of side chain at residue 1 upon the conformation and cytotoxic activity2004

    • Author(s)
      Yukio, Hitotsuyanagi, et. al.
    • Journal Title

      Tetrahedron Lett 45

      Pages: 935-938

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590015
  • [Journal Article] チオアミドを利用した抗腫瘍性環状ペプチドRA-VIIの化学修飾と配座構造一活性相関の解明2004

    • Author(s)
      一柳 幸生
    • Journal Title

      有機合成化学協会誌 62

      Pages: 993-1005

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16590015
  • [Presentation] Rubia cordifoliaより得られた新規環状ペプチドRA-XIX, -XX, -XXI及び-XXIIについて2008

    • Author(s)
      李 知彦, 一柳幸生, 竹谷孝一
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2008-03-26
    • Data Source
      KAKENHI-PROJECT-16590015
  • [Presentation] 抗腫瘍性環状ペプチドRA-VIIの芳香環部位の構造活性について2007

    • Author(s)
      李 知彦, 一柳幸生, 竹谷孝一
    • Organizer
      第五回次世代を担う有機化学シンポジウム
    • Place of Presentation
      日本薬学会長井記念ホール
    • Year and Date
      2007-05-25
    • Data Source
      KAKENHI-PROJECT-16590015
  • 1.  TAKEYA Koichi (20120149)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 2.  ITOKAWA Hideji (60057304)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  MORITA Hiroshi (70220069)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  塚越 茂 (60085644)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  FUKAYA Haruhiko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results

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