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IMAMURA Michihiro  今村 道博

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… Alternative Names

今村 道博  イマムラ ミチヒロ

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Researcher Number 80221787
Affiliation (Current) 2025: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 遺伝子疾患治療研究部, 研究員
Affiliation (based on the past Project Information) *help 2022 – 2023: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 遺伝子疾患治療研究部, 研究員
2016: 国立精神・神経医療研究センター, 神経研究所・遺伝子疾患治療研究部, 室長
2014: 独立行政法人国立精神・神経医療研究センター, 神経研究所 遺伝子疾患治療研究部, 室長
2013: 独立行政法人国立精神・神経医療研究センター, 神経研究所遺伝子疾患治療研究部, 室長
2012: 独立行政法人国立精神・神経医療研究センター, 神経研究所 遺伝子疾患治療研究部, 室長 … More
2010 – 2011: 独立行政法人国立精神・神経医療研究センター, 神経研究所・遺伝子疾患治療研究部, 室長
2010 – 2011: 独立行政法人国立精神・神経医療研究センター, 神経研究所遺伝子疾患治療研究部, 室長
2009: 国立精神・神経研究センター, 神経研究所・遺伝子疾患治療研究部, 室長
2009: National Center of Neurology and Psychiatry, 神経研究所 遺伝子疾患治療研究部, 室長
1995 – 1996: 国立精神・神経センター, 神経研究所・機能研究部, 室長
1995: 国立精神神経センター, 神経研究所, 主任研究員
1995: 国立精神神経センター, 神経研究所, 研究室長
1994: 群馬大学, 医学部・薬理学講座, 助手 Less
Review Section/Research Field
Principal Investigator
General medical chemistry / Neurophysiology and muscle physiology / Neurophysiology and muscle physiology / General pharmacology
Except Principal Investigator
Basic Section 56070:Plastic and reconstructive surgery-related / Biomedical engineering/Biomaterial science and engineering / 応用薬理学・医療系薬学 / Neurophysiology and muscle physiology
Keywords
Principal Investigator
筋ジストロフィー / 実験動物 / 血管内皮細胞 / α-アクチニン / WWドメイン / HECTドメイン / 骨格筋 / サルコグリカン / ジストログリカン / HECT型E3ユビキチンリガーゼ … More / ミトコンドリア / 筋小胞 / 筋形質膜 / ミスセンス変異 / E3ユビキチンリガーゼ / WWP1 / タンパク質分解 / WWP1 E3 ユビキチンリガーゼ / 遺伝子疾患 / 遺伝子 / 細胞組織 / 酵素 / 培養 / アガロース / コラーゲン / 管腔形成 / リコンビナント蛋白質 / EF-ハンドモチーフ / カルシウム / アクチン / PIP_2 … More
Except Principal Investigator
メカノバイオロジー / ミオシン軽鎖キナーゼ / ミオシン / カルシウム応答 / 管腔形成 / リンパ管内皮細胞 / 圧刺激 / リンパ浮腫 / リンパ管形成 / 定圧刺激 / 細胞バイオメカニクス / 非筋α-アクチニン / 焦点接着斑 / ストレスファイバー / recombinant protein / nerve cell / actin / PC-12 Cell / Cytoskeleton / patch clamp / capsicin receptor / purinergic receptor / アクトミオシン / ATPase / 血管 / 創薬 / 収縮制御 / フォスファターゼ / リン酸化 / スクリーニング / 創藥 / 血管平滑筋 / ニトロシル化 / nNOS / 筋ジストロフィー / 萎縮 / 筋肥大 / 神経型一酸化窒素合成酵素 / 一酸化窒素 / 筋萎縮 / 骨格筋 / 強心作用 / アクチン / カルシウムイオン / 心筋 Less
  • Research Projects

    (10 results)
  • Research Products

    (14 results)
  • Co-Researchers

    (13 People)
  •  Investigation of the effect and mechanism of constant compression stimulation on human lymphatic endothelial cells

    • Principal Investigator
      高田 弘弥
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56070:Plastic and reconstructive surgery-related
    • Research Institution
      Nippon Medical School
  •  3D microstructure of actin stress fibers

    • Principal Investigator
      Deguchi Shinji
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Biomedical engineering/Biomaterial science and engineering
    • Research Institution
      Osaka University
      Nagoya Institute of Technology
  •  Molecular characterization of a HECT-type E3 ubiquitin ligase that is encoded in the WWP1 gene responsible for chicken muscular dystrophy.Principal Investigator

    • Principal Investigator
      IMAMURA Michihiro
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurophysiology and muscle physiology
    • Research Institution
      National Center of Neurology and Psychiatry
  •  The elucidation of the molecular mechanisms of NO-mediated muscle atrophy

    • Principal Investigator
      TAKEDA Shin ichi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurophysiology and muscle physiology
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Generation and characterization of transgenic mice expressing mutated WWP1 gene responsible for chicken muscular dystrophyPrincipal Investigator

    • Principal Investigator
      IMAMURA Michihiro
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurophysiology and muscle physiology
    • Research Institution
      National Center of Neurology and Psychiatry
  •  培養血管内皮細胞を用いた新しい血管形成モデルPrincipal Investigator

    • Principal Investigator
      今村 道博
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      General pharmacology
    • Research Institution
      National Center of Neurology and Psychiatry
  •  心筋ミオシン軽鎖キナーゼのアクチン結合を少した新しい収縮抑制様式の検討

    • Principal Investigator
      KOHAMA Kazuhiro
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Gunma University
  •  α-アクチニン分子のアクチン結合におけるカルシウム調節機構の解析Principal Investigator

    • Principal Investigator
      今村 道博
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      General medical chemistry
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Screening for the smooth muscle relaxants

    • Principal Investigator
      KOHAMA Kazuhiro
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Gunma University School of Medicine
  •  α-アクチニンのCa^<2+>感受性に及ぼすPIP_2の作用の解析Principal Investigator

    • Principal Investigator
      今村 道博
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      General medical chemistry
    • Research Institution
      Gunma University

All 2016 2013 2012 2011 2010 2009 Other

All Journal Article Presentation

  • [Journal Article] Intracellular polarity protein PAR-1 regulates extracellular laminin assembly by regulating the dystroglycan complex2009

    • Author(s)
      Masuda-Hirata M, Suzuki A, Amano Y, Yamashita K, Ide M, Yamanaka T, Sakai M, Imamura M, Ohno S
    • Journal Title

      Genes to Cells 14

      Pages: 835-850

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500384
  • [Journal Article]2009

    • Author(s)
      Masuda-Hirata M, Suzuki A, Amano Y, Yamashita K, Ide M, Yamanaka T, Sakai M, Imamura M, Ohno S
    • Journal Title

      Genes to Cells

      Volume: vol.14 Issue: 7 Pages: 835-850

    • DOI

      10.1111/j.1365-2443.2009.01315.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500384
  • [Presentation] 焦点接着斑の微細構造に関する研究2016

    • Author(s)
      大石泰己、松井翼、今村道博、出口
    • Organizer
      日本機械学会第28回バイオエンジニアリング講演会
    • Place of Presentation
      東京工業大学
    • Year and Date
      2016-01-09
    • Data Source
      KAKENHI-PROJECT-26560208
  • [Presentation] Analysis of Interaction of WWP1 E3 Ubiquitin Protein Ligase with Dystrophin-Associated Glycoproteins2013

    • Author(s)
      Imamura M, Takeda S
    • Organizer
      53rd American Society for Cell Biology Annual Meeting
    • Place of Presentation
      Ernest N. Morial Convention Center, New Orleans, Louisiana, USA
    • Data Source
      KAKENHI-PROJECT-24500472
  • [Presentation] An R441Q mutation of the WWP1 gene causes WWP1 degradation in skeletal muscle of chicken muscular dystrophy2012

    • Author(s)
      Imamura M and Takeda S
    • Organizer
      The American Society for Cell Biology 2012 Annual Meeting
    • Place of Presentation
      Moscone Center, San Francisco , USA
    • Data Source
      KAKENHI-PROJECT-24500472
  • [Presentation]2011

    • Author(s)
      Imamura M, Takeda S
    • Organizer
      51^<th> Annual Meeting American Society for Cell Biology
    • Place of Presentation
      Denver(U. S. A.)
    • Data Source
      KAKENHI-PROJECT-21500384
  • [Presentation] Analysis of Expression of WWP1 protein in Mouse Normal Tissues2011

    • Author(s)
      IMAMURA, Michihiro
    • Organizer
      51^<st> American Society for Cell Biology Annual Meeting
    • Place of Presentation
      Colorado Convention Center, Denver, USA
    • Year and Date
      2011-12-04
    • Data Source
      KAKENHI-PROJECT-21500384
  • [Presentation] Effect of a Point Mutation in the WWP1 Gene Associated with Chicken Muscular Dystrophy on Mouse Muscle Expressing Mutated WWP1 Transgene2011

    • Author(s)
      今村道博
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      北海道大学クラーク会館,北海道
    • Year and Date
      2011-06-28
    • Data Source
      KAKENHI-PROJECT-21500384
  • [Presentation] Generation of transgenic mouse expressing mutated wwp1 gene responsible for chicken muscular dystrophy.2010

    • Author(s)
      Imamura M, Matsumoto H, Inaba Y, Mannen H, Takeda S
    • Organizer
      American Society for Cell Biology
    • Place of Presentation
      Pennsylvania Convention Center, Philadelphia, PA, USA
    • Year and Date
      2010-12-14
    • Data Source
      KAKENHI-PROJECT-21500384
  • [Presentation]2010

    • Author(s)
      Imamura M, Takeda S
    • Organizer
      50^<th> Annual Meeting American Society for Cell Biology
    • Place of Presentation
      Philadelphia(U. S. A.)
    • Data Source
      KAKENHI-PROJECT-21500384
  • [Presentation]2010

    • Author(s)
      今村道博,松本大和,稲葉由美,万年英之,武田伸一
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-21500384
  • [Presentation] Searching for loss of imprinting of theε-sarcoglycan gene in the cells of ε-sarcoglycan partial knockout mice2009

    • Author(s)
      Imamura M, Takeda S
    • Organizer
      American Society for Cell Biology
    • Place of Presentation
      San Diego Convention Center San Diego, CA, USA
    • Year and Date
      2009-12-08
    • Data Source
      KAKENHI-PROJECT-21500384
  • [Presentation]2009

    • Author(s)
      Imamura M, Takeda S
    • Organizer
      49^<th> Annual Meeting American Society for Cell Biology
    • Place of Presentation
      San Diego(U. S. A.)
    • Data Source
      KAKENHI-PROJECT-21500384
  • [Presentation] Differences in Degradation and Distribution of Mutated WP1 E3 Ubiquitin Protein Ligase between Chicken and Mouse Skeletal Muscles

    • Author(s)
      Imamura, M., Takeda, S.
    • Organizer
      American Society for Cell Biology
    • Place of Presentation
      Pennsylvania Convention Center, Philadelphia, PA, U.S.A.
    • Year and Date
      2014-12-06 – 2014-12-10
    • Data Source
      KAKENHI-PROJECT-24500472
  • 1.  TAKEDA Shin ichi (90171644)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 2.  KOHAMA Kazuhiro (30101116)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  ISHIKAWA Ryoki (20212863)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  SUZUKI Yuuko (00342931)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  MANNEN Hideyuki (20263395)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 6.  OKAGAKI Tsuyoshi (80185412)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  Deguchi Shinji (30379713)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  MATSUI Tsubasa (50638707)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  上野 裕則 (70518240)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  高田 弘弥 (30824833)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  古家 喜四夫 (40132740)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  SAIDA Koichi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  NAKAMURA Akio
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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