SAWA Hitoshi 澤斉

Researcher Number	80222024
Other IDs
External Links
Affiliation (Current)	2019: 国立遺伝学研究所, 遺伝形質研究系, 教授
Affiliation (based on the past Project Information) *help	2010 – 2018: 国立遺伝学研究所, 構造遺伝学研究センター, 教授 2015: 独立行政法人理化学研究所, 細胞運命研究チーム, チームリーダー 2010: The Institute of Physical and Chemical Research, 構造遺伝学研究センター, 教授 2007 – 2009: The Institute of Physical and Chemical Research, 細胞運命研究チーム, チームリーダー 2003 – 2005: RIKEN, Laboratory for Cell Fate Decision, Team Leader, 細胞運命研究チーム, チームリーダー 2002: 理化学研究所, 細胞運命研究チーム, チームリーダー
Review Section/Research Field	Principal Investigator Biological Sciences / Developmental biology / Developmental biology / Cell biology / Constructive Systems Biology Except Principal Investigator Biological Sciences
Keywords	Principal Investigator Wnt / 非対称分裂 / 細胞極性 / C.elegans / C. elegans / βカテニン / Frizzled / 非対称細胞分裂 / 線虫 / 幹細胞 … More Except Principal Investigator 器官形成 / 体軸形成 / 数理モデル / 力学的パラメータ / パターン形成 / 力学的パラメーター Less

左右の非対称性を使って前後方向に鏡像対称な器官を作る機構の研究Principal InvestigatorOngoing
- Principal Investigator
  
  澤斉
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Developmental biology
- Research Institution
  National Institute of Genetics
Wntによる細胞極性同調モデルの証明Principal InvestigatorOngoing
- Principal Investigator
  
  澤斉
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Constructive Systems Biology
- Research Institution
  National Institute of Genetics
Visualization of DNA binding proteins bound to specific loci in vivoPrincipal Investigator
- Principal Investigator
  
  Sawa Hitoshi
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  National Institute of Genetics
Logic that coordinates cell polarity along the body axisPrincipal Investigator
- Principal Investigator
  
  HITOSHI Sawa
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Genetics
Management of the research group on logic for biological pattern formation
- Principal Investigator
  
  TAKEDA Hiroyuki
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
五種類のWntと四種類のFrizzledによる非対称分裂制御ネットワークの解明Principal Investigator
- Principal Investigator
  
  澤斉
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Mechanisms of a novel Wnt signaling pathway regulating asymmetric divisionPrincipal Investigator
- Principal Investigator
  
  SAWA Hitoshi
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Developmental biology
- Research Institution
  The Institute of Physical and Chemical Research
βカテニンとLIT-1キナーゼによる非対称分裂機構の研究Principal Investigator
- Principal Investigator
  
  澤斉
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
線虫におけるMeis/Pbx/Hoxによる非対称細胞分裂制御機構の研究Principal Investigator
- Principal Investigator
  
  澤斉
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Molecular genetic studies of asymmetric cell division in C.elegansPrincipal Investigator
- Principal Investigator
  
  SAWA Hitoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Developmental biology
- Research Institution
  RIKEN

All 2018 2017 2016 2015 2013 2012 2010 2009 2008 2007 2005 Other

All Journal Article Presentation

[Journal Article] Tumor suppressor APC is an attenuator of spindle-pulling forces duringC. elegansasymmetric cell division2018
- Author(s)
  Sugioka Kenji、Fielmich Lars-Eric、Mizumoto Kota、Bowerman Bruce、van den Heuvel Sander、Kimura Akatsuki、Sawa Hitoshi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 115
- DOI
  10.1073/pnas.1712052115
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KT0083, KAKENHI-PROJECT-16KT0078, KAKENHI-PUBLICLY-16H00816, KAKENHI-PROJECT-15H04372, KAKENHI-PROJECT-16H04797
[Journal Article] PIGN prevents protein aggregation in the endoplasmic reticulum independently of its function in the GPI synthesis2017
- Author(s)
  Ihara S, Nakayama S, Murakami Y, Suzuki E, Asakawa M, Kinoshita T, Sawa H.
- Journal Title
  
  Journal of cell science
  
  Volume: 130 Pages: 602-613
- DOI
  10.1242/jcs.196717
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H04797, KAKENHI-PROJECT-16KT0078, KAKENHI-PROJECT-15K07063
[Journal Article] The Mediator Kinase Module Restrains Epidermal Growth Factor Receptor Signaling and Represses Vulval Cell Fate Specification in Caenorhabditis elegans.2016
- Author(s)
  Grants JM, Ying LT, Yoda A, You CC, Okano H, Sawa H, Taubert S.
- Journal Title
  
  Genetics
  
  Volume: 202(2) Pages: 583-599
- DOI
  10.1534/genetics.115.180265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K14514
[Journal Article] Power law relationship between cell cycle duration and cell volume in the early embryonic development of Caenorhabditis elegans.2015
- Author(s)
  Arata, Y., Takagi, H., Sako, Y., and Sawa. H.
- Journal Title
  
  Front. Physiol.
  
  Volume: 28 Pages: 1-11
- DOI
  10.3389/fphys.2014.00529
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22127005, KAKENHI-PROJECT-24770221, KAKENHI-PROJECT-25600051, KAKENHI-PROJECT-15K14514
[Journal Article] HTZ-1/H2A.z and MYS-1/MYST HAT act redundantly to maintain cell fates in somatic gonadal cells through repression of ceh-22 in Caenorhabditis elegans.2013
- Author(s)
  Shibata, Y., Sawa, H. and Nishiwaki, K.
- Journal Title
  
  Development
  
  Volume: 141 Pages: 209-218
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22127005
[Journal Article] Wnt signaling in C. elegans.2013
- Author(s)
  Sawa H. & Korswagen H. C.
- Journal Title
  
  The C. elegans Research Community, WormBook
  
  Volume: - Pages: 1-30
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22127005
[Journal Article] Multiple functions of PBRM-1/Polybromo- and LET-526/Osa- containing chromatin remodeling complexes in C. elegans development2012
- Author(s)
  Shibata Y, Uchida M, Takeshita H, Nishiwaki K., Sawa H
- Journal Title
  
  Dev.Biol.
  
  Volume: 361 Pages: 349-357
- DOI
  10.1016/j.ydbio.2011.10.035
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22111001, KAKENHI-ORGANIZER-22127001, KAKENHI-PLANNED-22127005, KAKENHI-PROJECT-23770257
[Journal Article] The Medaka zic1/zic4 Mutant Provides Molecular Insights into Teleost Caudal Fin Evolution.2012
- Author(s)
  Yuuta Moriyama
- Journal Title
  
  Current biology (pub;ished on line at 3/1 2012)
  
  Volume: 21 Pages: 601-601
- DOI
  10.1016/j.cub.2012.01.063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J07483, KAKENHI-PROJECT-10J09017, KAKENHI-PROJECT-11J05881, KAKENHI-PROJECT-20247030, KAKENHI-PROJECT-21370098, KAKENHI-PROJECT-21370103, KAKENHI-PROJECT-21570219, KAKENHI-ORGANIZER-22127001, KAKENHI-PLANNED-22127002, KAKENHI-PROJECT-22370075, KAKENHI-PROJECT-22570218, KAKENHI-PROJECT-22657055, KAKENHI-PROJECT-22700428, KAKENHI-PROJECT-22870008, KAKENHI-PROJECT-23241058, KAKENHI-PROJECT-23570077, KAKENHI-PROJECT-24370088, KAKENHI-PROJECT-24657147, KAKENHI-PROJECT-24657152
[Journal Article] Control of Cell Polarity and Asymmetric Division in C. elegans.2012
- Author(s)
  Sawa ,H.
- Journal Title
  
  Current Topic in Developmental Biology
  
  Volume: 101 Pages: 55-76
- DOI
  10.1016/b978-0-12-394592-1.00003-x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22127005
[Journal Article] Regulation of asymmetric positioning of nuclei by Wnt and Src signaling and its roles in POP-1/TCF nuclear asymmetry in C. elegans2010
- Author(s)
  杉岡賢史, 澤斉
- Journal Title
  
  Genes to Cells 15
  
  Pages: 397-407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19207017
[Journal Article] Specification of neurons through asymmetric cell divisions2010
- Author(s)
  澤斉
- Journal Title
  
  Curr Opinion in Neurobiol 20
  
  Pages: 44-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19207017
[Journal Article] Double bromodomain protein BET-1 and MYST HATs establish and maintain stable cell fates in C. elegans2010
- Author(s)
  柴田幸政, 竹下久子, 笹川典子, 澤斉
- Journal Title
  
  Development 137
  
  Pages: 1045-1053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19207017
[Journal Article] Regulation of asymmetric positioning of nuclei by Wnt and Src signaling and its roles in POP-1/TCF nuclear asymmetry in C.elegans.2010
- Author(s)
  Sugioka K., Sawa H.
- Journal Title
  
  Genes to Cells 15
  
  Pages: 397-407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19207017
[Journal Article] Double bromodomain protein BET-1 and MYST HATs establish and maintain stable cell fates in C.elegans.2010
- Author(s)
  Shibata Y., Takeshita H., Sasakawa N., Sawa H.
- Journal Title
  
  Development 137
  
  Pages: 1045-1053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19207017
[Journal Article] Specification of neurons through asymmetric cell divisions.2010
- Author(s)
  Sawa H.
- Journal Title
  
  Current Opinion in Neurobiology 20
  
  Pages: 44-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19207017
[Journal Article] Complex network of Wnt signaling regulates neuronal migrations during C. elegans development2008
- Author(s)
  Zinovyeva A. Y., Yamamoto Y., Sawa H., Forrester W. C.
- Journal Title
  
  Genetics 179
  
  Pages: 1357-1371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19207017
[Journal Article] β-Catenin asymmetry is regulated by PLA1 and retrograde traffic in C.elegans stem cell divisions2008
- Author(s)
  Kanamori T., Inoue T., Sakamoto T., Gengyo-Ando K., Tsujimoto M., Mitani S., Sawa H., Aoki J.and Arai H.
- Journal Title
  
  EMBO Journal 27
  
  Pages: 1647-1657
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20057031
[Journal Article] Complex network of Wnt signaling regulates neuronal migrations suring C. eleganse development.2008
- Author(s)
  Zinovyeva A.Y., Yamamoto Y., Sawa H.and Forrester W.C.
- Journal Title
  
  Genetics 179
  
  Pages: 1357-1371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20057031
[Journal Article] β-Catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions2008
- Author(s)
  Kanamori T., Inoue T., Sakamoto T., Gengyo-Ando K., Tsujimoto M., Mitani S., Sawa H., Aoki J., Arai H.
- Journal Title
  
  EMBO Journal 27
  
  Pages: 1647-1657
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19207017
[Journal Article] β-Catenin asymmetry is regulated by PLA1 and retrograde traffic in C.elegans stem cell divisions.2008
- Author(s)
  Kanamori T., Inoue T., Sakamoto T., Gengyo-Ando K., Tsujimoto M., Mitani S., Sawa H., Aoki J., Arai H.
- Journal Title
  
  EMBO Journal 27
  
  Pages: 1647-1657
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19207017
[Journal Article] Complex network of Wnt signaling regulates neuronal migrations during C.elegans development2008
- Author(s)
  Zinovyeva AY, 山本優子, 澤斉, Forrester WC
- Journal Title
  
  Genetics 179
  
  Pages: 1357-1371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19207017
[Journal Article] Two βs or not two βs: regulation of asymmetric division by β-catenin2007
- Author(s)
  Mizumoto K., Sawa H.
- Journal Title
  
  Trends in Cell Biology 17
  
  Pages: 465-473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19207017
[Journal Article] RMD-1, a novel microtubule-associated protein functions in chromosome segregation in Caenorhabditis elegans.2007
- Author(s)
  Oishi K., Okano H., Sawa H.
- Journal Title
  
  Journal of Cell Biology 179
  
  Pages: 1149-1162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19207017
[Journal Article] Cyclin E and CDK2 repress the terminal differentiation of quiescent cells after asymmetric division in C.elegans.2007
- Author(s)
  Fujita M., Takeshita H., Sawa H.
- Journal Title
  
  PLoS ONE 2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19207017
[Journal Article] 線虫C.elegansにおける蛍光イメージング実験2005
- Author(s)
  澤斉
- Journal Title
  
  バイオテクノロジージャーナル Vol.5 No.3
  
  Pages: 321-326
- Data Source
  KAKENHI-PROJECT-16027259
[Presentation] Orienting cell polarity by Wnt signaling2016
- Author(s)
  HItoshi Sawa
- Organizer
  The 7th Asia-Pasific C. elegans Meeting
- Place of Presentation
  The Friendship Hotel of Beijing
- Year and Date
  2016-06-25
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-16H04797
[Presentation] C.elegans 発生時におけるPOP-1/TCF標的遺伝子の核内位置の変化2015
- Author(s)
  澤　斉
- Organizer
  第67回日本細胞生物学会大会
- Place of Presentation
  タワーホール船堀
- Year and Date
  2015-06-30
- Invited
- Data Source
  KAKENHI-PROJECT-15K14514
[Presentation] Multiple WNTs regulate polarities of seam cells during asymmetric divisions in C.elegans.2010
- Author(s)
  Yuko Yamamoto, Hisako Takeshita, Hitoshi Sawa
- Organizer
  EMBO Conference Series : C. elegans : Development and Gene Expression June
- Place of Presentation
  Heidelberg. Germany
- Year and Date
  2010-06-19
- Data Source
  KAKENHI-PROJECT-19207017
[Presentation] A network of multiple Wnts and their receptors synchronizes polarities of epithelial stem cells in C.elegans2010
- Author(s)
  澤斉
- Organizer
  European Wnt meeting
- Place of Presentation
  Stockholm
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PROJECT-19207017
[Presentation] Regulation of Asymmetric Cell Division by Wnt Signaling in C.elegans2009
- Author(s)
  澤斉
- Organizer
  CDB Symposium "Shape & Polarity"
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19207017
[Presentation] Regulation of asymmetric cell division by Wnt signaling through asymmetric spindle microtubules in C.elegans2009
- Author(s)
  澤斉
- Organizer
  国際発生生物学会(Kenji Sugioka and Hitoshi Sawa)
- Place of Presentation
  エジンバラUK
- Year and Date
  2009-09-08
- Data Source
  KAKENHI-PROJECT-19207017
[Presentation] Wntによる非対称分裂制御機構2009
- Author(s)
  澤斉
- Organizer
  日本生化学会年会
- Place of Presentation
  神戸
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-19207017
[Presentation] Life without Wnts; Wnt dependent and independent regulation of beta- catenin by Frizzled in cell polarization2007
- Author(s)
  澤斉
- Organizer
  Wnt-Signaling in Development and Disease
- Place of Presentation
  Berlin, Germany
- Year and Date
  2007-09-14
- Data Source
  KAKENHI-PROJECT-19207017
[Presentation] Life without Wnts:Wnt dependent and independent cell polarization2007
- Author(s)
  澤斉
- Organizer
  Sixteenth International C. elegans Meeting
- Place of Presentation
  Los Angeles,USA
- Year and Date
  2007-06-28
- Data Source
  KAKENHI-PROJECT-19207017
[Presentation] Regulation of asymmetric cell division by Wnt signaling
- Author(s)
  HItoshi Sawa
- Organizer
  EMBO Workshop pn Wnt signaling
- Place of Presentation
  Cable Beach Club Resort ブルーム、オーストラリア
- Year and Date
  2014-10-06 – 2014-10-09
- Invited
- Data Source
  KAKENHI-PLANNED-22127005
[Presentation] Regulation of asymmetric cell division by Wnt signaling in C. elegans
- Author(s)
  澤　斉
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Invited
- Data Source
  KAKENHI-PLANNED-22127005

1. UENO Naoto (40221105)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. TAKEDA Hiroyuki (80179647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. KONDO Shigeru (10252503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. OGURA Toshihiko (60273851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MATSUMOTO Takeo (30209639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MATSUNO Kenji (60318227)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NISHIWAKI Kiyoji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. KIMURA Akatsuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. TSUKAHARA Tatsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. ARATA Yukinobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 柴田幸政

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 日比正彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 島田敦子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 平良眞規

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 清水厚志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 佐甲靖志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 伊原伸治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAWA Hitoshi 澤 斉

Research Projects

Research Products

Co-Researchers

左右の非対称性を使って前後方向に鏡像対称な器官を作る機構の研究Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Wntによる細胞極性同調モデルの証明Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Visualization of DNA binding proteins bound to specific loci in vivoPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Logic that coordinates cell polarity along the body axisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Management of the research group on logic for biological pattern formation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

五種類のWntと四種類のFrizzledによる非対称分裂制御ネットワークの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of a novel Wnt signaling pathway regulating asymmetric divisionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

βカテニンとLIT-1キナーゼによる非対称分裂機構の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

線虫におけるMeis/Pbx/Hoxによる非対称細胞分裂制御機構の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular genetic studies of asymmetric cell division in C.elegansPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Tumor suppressor APC is an attenuator of spindle-pulling forces duringC. elegansasymmetric cell division2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PIGN prevents protein aggregation in the endoplasmic reticulum independently of its function in the GPI synthesis2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Mediator Kinase Module Restrains Epidermal Growth Factor Receptor Signaling and Represses Vulval Cell Fate Specification in Caenorhabditis elegans.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Power law relationship between cell cycle duration and cell volume in the early embryonic development of Caenorhabditis elegans.2015

SAWA Hitoshi 澤斉