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SAWA Hitoshi  澤 斉

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Researcher Number 80222024
Other IDs
External Links
Affiliation (Current) 2019: 国立遺伝学研究所, 遺伝形質研究系, 教授
Affiliation (based on the past Project Information) *help 2010 – 2018: 国立遺伝学研究所, 構造遺伝学研究センター, 教授
2015: 独立行政法人理化学研究所, 細胞運命研究チーム, チームリーダー
2010: The Institute of Physical and Chemical Research, 構造遺伝学研究センター, 教授
2007 – 2009: The Institute of Physical and Chemical Research, 細胞運命研究チーム, チームリーダー
2003 – 2005: RIKEN, Laboratory for Cell Fate Decision, Team Leader, 細胞運命研究チーム, チームリーダー
2002: 理化学研究所, 細胞運命研究チーム, チームリーダー
Review Section/Research Field
Principal Investigator
Biological Sciences / Developmental biology / Developmental biology / Cell biology / Constructive Systems Biology
Except Principal Investigator
Biological Sciences
Keywords
Principal Investigator
Wnt / 非対称分裂 / 細胞極性 / C.elegans / C. elegans / βカテニン / Frizzled / 非対称細胞分裂 / 線虫 / 幹細胞 … More / Meis / Pbx / Hox / psa-3 / 微小管 / 非対称細胞 / PCP / 細胞移動 / cyclin E / TCF / Wmt / LIT-1 / WRM-1 / 核局在 / 紡錘体 / キナーゼ / 冗長性 / Fizzled / APC / 臓器形成 / 濃度勾配 / SWI / SNF複合体 / Mediator複合体 / 微少管 / SNF / サイクリンE / asymmetric cell division / cell polarity / SWl / SNF complex / Mediator complex / microtubule / エピジェネティックス / イメージング / ヒストン修飾 / 器官構築 / 器官形成 / 左右非対称 / 細胞形態 … More
Except Principal Investigator
器官形成 / 体軸形成 / 数理モデル / 力学的パラメータ / パターン形成 / 力学的パラメーター Less
  • Research Projects

    (10 results)
  • Research Products

    (36 results)
  • Co-Researchers

    (17 People)
  •  左右の非対称性を使って前後方向に鏡像対称な器官を作る機構の研究Principal InvestigatorOngoing

    • Principal Investigator
      澤 斉
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Developmental biology
    • Research Institution
      National Institute of Genetics
  •  Wntによる細胞極性同調モデルの証明Principal InvestigatorOngoing

    • Principal Investigator
      澤 斉
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Constructive Systems Biology
    • Research Institution
      National Institute of Genetics
  •  Visualization of DNA binding proteins bound to specific loci in vivoPrincipal Investigator

    • Principal Investigator
      Sawa Hitoshi
    • Project Period (FY)
      2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Cell biology
    • Research Institution
      National Institute of Genetics
  •  Logic that coordinates cell polarity along the body axisPrincipal Investigator

    • Principal Investigator
      HITOSHI Sawa
    • Project Period (FY)
      2010 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      National Institute of Genetics
  •  Management of the research group on logic for biological pattern formation

    • Principal Investigator
      TAKEDA Hiroyuki
    • Project Period (FY)
      2010 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  五種類のWntと四種類のFrizzledによる非対称分裂制御ネットワークの解明Principal Investigator

    • Principal Investigator
      澤 斉
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Mechanisms of a novel Wnt signaling pathway regulating asymmetric divisionPrincipal Investigator

    • Principal Investigator
      SAWA Hitoshi
    • Project Period (FY)
      2007 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Developmental biology
    • Research Institution
      The Institute of Physical and Chemical Research
  •  βカテニンとLIT-1キナーゼによる非対称分裂機構の研究Principal Investigator

    • Principal Investigator
      澤 斉
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research
  •  線虫におけるMeis/Pbx/Hoxによる非対称細胞分裂制御機構の研究Principal Investigator

    • Principal Investigator
      澤 斉
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Molecular genetic studies of asymmetric cell division in C.elegansPrincipal Investigator

    • Principal Investigator
      SAWA Hitoshi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Developmental biology
    • Research Institution
      RIKEN

All 2018 2017 2016 2015 2013 2012 2010 2009 2008 2007 2005 Other

All Journal Article Presentation

  • [Journal Article] Tumor suppressor APC is an attenuator of spindle-pulling forces duringC. elegansasymmetric cell division2018

    • Author(s)
      Sugioka Kenji、Fielmich Lars-Eric、Mizumoto Kota、Bowerman Bruce、van den Heuvel Sander、Kimura Akatsuki、Sawa Hitoshi
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 115

    • DOI
      10.1073/pnas.1712052115
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15KT0083, KAKENHI-PROJECT-16KT0078, KAKENHI-PUBLICLY-16H00816, KAKENHI-PROJECT-15H04372, KAKENHI-PROJECT-16H04797
  • [Journal Article] PIGN prevents protein aggregation in the endoplasmic reticulum independently of its function in the GPI synthesis2017

    • Author(s)
      Ihara S, Nakayama S, Murakami Y, Suzuki E, Asakawa M, Kinoshita T, Sawa H.
    • Journal Title

      Journal of cell science

      Volume: 130 Pages: 602-613

    • DOI
      10.1242/jcs.196717
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16H04797, KAKENHI-PROJECT-16KT0078, KAKENHI-PROJECT-15K07063
  • [Journal Article] The Mediator Kinase Module Restrains Epidermal Growth Factor Receptor Signaling and Represses Vulval Cell Fate Specification in Caenorhabditis elegans.2016

    • Author(s)
      Grants JM, Ying LT, Yoda A, You CC, Okano H, Sawa H, Taubert S.
    • Journal Title

      Genetics

      Volume: 202(2) Pages: 583-599

    • DOI
      10.1534/genetics.115.180265
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K14514
  • [Journal Article] Power law relationship between cell cycle duration and cell volume in the early embryonic development of Caenorhabditis elegans.2015

    • Author(s)
      Arata, Y., Takagi, H., Sako, Y., and Sawa. H.
    • Journal Title

      Front. Physiol.

      Volume: 28 Pages: 1-11

    • DOI
      10.3389/fphys.2014.00529
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-22127005, KAKENHI-PROJECT-24770221, KAKENHI-PROJECT-25600051, KAKENHI-PROJECT-15K14514
  • [Journal Article] HTZ-1/H2A.z and MYS-1/MYST HAT act redundantly to maintain cell fates in somatic gonadal cells through repression of ceh-22 in Caenorhabditis elegans.2013

    • Author(s)
      Shibata, Y., Sawa, H. and Nishiwaki, K.
    • Journal Title

      Development

      Volume: 141 Pages: 209-218

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22127005
  • [Journal Article] Wnt signaling in C. elegans.2013

    • Author(s)
      Sawa H. & Korswagen H. C.
    • Journal Title

      The C. elegans Research Community, WormBook

      Volume: - Pages: 1-30

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22127005
  • [Journal Article] Multiple functions of PBRM-1/Polybromo- and LET-526/Osa- containing chromatin remodeling complexes in C. elegans development2012

    • Author(s)
      Shibata Y, Uchida M, Takeshita H, Nishiwaki K., Sawa H
    • Journal Title

      Dev.Biol.

      Volume: 361 Pages: 349-357

    • DOI
      10.1016/j.ydbio.2011.10.035
    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22111001, KAKENHI-ORGANIZER-22127001, KAKENHI-PLANNED-22127005, KAKENHI-PROJECT-23770257
  • [Journal Article] The Medaka zic1/zic4 Mutant Provides Molecular Insights into Teleost Caudal Fin Evolution.2012

    • Author(s)
      Yuuta Moriyama
    • Journal Title

      Current biology (pub;ished on line at 3/1 2012)

      Volume: 21 Pages: 601-601

    • DOI
      10.1016/j.cub.2012.01.063
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J07483, KAKENHI-PROJECT-10J09017, KAKENHI-PROJECT-11J05881, KAKENHI-PROJECT-20247030, KAKENHI-PROJECT-21370098, KAKENHI-PROJECT-21370103, KAKENHI-PROJECT-21570219, KAKENHI-ORGANIZER-22127001, KAKENHI-PLANNED-22127002, KAKENHI-PROJECT-22370075, KAKENHI-PROJECT-22570218, KAKENHI-PROJECT-22657055, KAKENHI-PROJECT-22700428, KAKENHI-PROJECT-22870008, KAKENHI-PROJECT-23241058, KAKENHI-PROJECT-23570077, KAKENHI-PROJECT-24370088, KAKENHI-PROJECT-24657147, KAKENHI-PROJECT-24657152
  • [Journal Article] Control of Cell Polarity and Asymmetric Division in C. elegans.2012

    • Author(s)
      Sawa ,H.
    • Journal Title

      Current Topic in Developmental Biology

      Volume: 101 Pages: 55-76

    • DOI
      10.1016/b978-0-12-394592-1.00003-x
    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22127005
  • [Journal Article] Regulation of asymmetric positioning of nuclei by Wnt and Src signaling and its roles in POP-1/TCF nuclear asymmetry in C. elegans2010

    • Author(s)
      杉岡賢史, 澤斉
    • Journal Title

      Genes to Cells 15

      Pages: 397-407

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19207017
  • [Journal Article] Specification of neurons through asymmetric cell divisions2010

    • Author(s)
      澤斉
    • Journal Title

      Curr Opinion in Neurobiol 20

      Pages: 44-49

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19207017
  • [Journal Article] Double bromodomain protein BET-1 and MYST HATs establish and maintain stable cell fates in C. elegans2010

    • Author(s)
      柴田幸政, 竹下久子, 笹川典子, 澤斉
    • Journal Title

      Development 137

      Pages: 1045-1053

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19207017
  • [Journal Article] Regulation of asymmetric positioning of nuclei by Wnt and Src signaling and its roles in POP-1/TCF nuclear asymmetry in C.elegans.2010

    • Author(s)
      Sugioka K., Sawa H.
    • Journal Title

      Genes to Cells 15

      Pages: 397-407

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19207017
  • [Journal Article] Double bromodomain protein BET-1 and MYST HATs establish and maintain stable cell fates in C.elegans.2010

    • Author(s)
      Shibata Y., Takeshita H., Sasakawa N., Sawa H.
    • Journal Title

      Development 137

      Pages: 1045-1053

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19207017
  • [Journal Article] Specification of neurons through asymmetric cell divisions.2010

    • Author(s)
      Sawa H.
    • Journal Title

      Current Opinion in Neurobiology 20

      Pages: 44-49

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19207017
  • [Journal Article] Complex network of Wnt signaling regulates neuronal migrations during C. elegans development2008

    • Author(s)
      Zinovyeva A. Y., Yamamoto Y., Sawa H., Forrester W. C.
    • Journal Title

      Genetics 179

      Pages: 1357-1371

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19207017
  • [Journal Article] β-Catenin asymmetry is regulated by PLA1 and retrograde traffic in C.elegans stem cell divisions2008

    • Author(s)
      Kanamori T., Inoue T., Sakamoto T., Gengyo-Ando K., Tsujimoto M., Mitani S., Sawa H., Aoki J.and Arai H.
    • Journal Title

      EMBO Journal 27

      Pages: 1647-1657

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057031
  • [Journal Article] Complex network of Wnt signaling regulates neuronal migrations suring C. eleganse development.2008

    • Author(s)
      Zinovyeva A.Y., Yamamoto Y., Sawa H.and Forrester W.C.
    • Journal Title

      Genetics 179

      Pages: 1357-1371

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057031
  • [Journal Article] β-Catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions2008

    • Author(s)
      Kanamori T., Inoue T., Sakamoto T., Gengyo-Ando K., Tsujimoto M., Mitani S., Sawa H., Aoki J., Arai H.
    • Journal Title

      EMBO Journal 27

      Pages: 1647-1657

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19207017
  • [Journal Article] β-Catenin asymmetry is regulated by PLA1 and retrograde traffic in C.elegans stem cell divisions.2008

    • Author(s)
      Kanamori T., Inoue T., Sakamoto T., Gengyo-Ando K., Tsujimoto M., Mitani S., Sawa H., Aoki J., Arai H.
    • Journal Title

      EMBO Journal 27

      Pages: 1647-1657

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19207017
  • [Journal Article] Complex network of Wnt signaling regulates neuronal migrations during C.elegans development2008

    • Author(s)
      Zinovyeva AY, 山本優子, 澤斉, Forrester WC
    • Journal Title

      Genetics 179

      Pages: 1357-1371

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19207017
  • [Journal Article] Two βs or not two βs: regulation of asymmetric division by β-catenin2007

    • Author(s)
      Mizumoto K., Sawa H.
    • Journal Title

      Trends in Cell Biology 17

      Pages: 465-473

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19207017
  • [Journal Article] RMD-1, a novel microtubule-associated protein functions in chromosome segregation in Caenorhabditis elegans.2007

    • Author(s)
      Oishi K., Okano H., Sawa H.
    • Journal Title

      Journal of Cell Biology 179

      Pages: 1149-1162

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19207017
  • [Journal Article] Cyclin E and CDK2 repress the terminal differentiation of quiescent cells after asymmetric division in C.elegans.2007

    • Author(s)
      Fujita M., Takeshita H., Sawa H.
    • Journal Title

      PLoS ONE 2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19207017
  • [Journal Article] 線虫C.elegansにおける蛍光イメージング実験2005

    • Author(s)
      澤 斉
    • Journal Title

      バイオテクノロジージャーナル Vol.5 No.3

      Pages: 321-326

    • Data Source
      KAKENHI-PROJECT-16027259
  • [Presentation] Orienting cell polarity by Wnt signaling2016

    • Author(s)
      HItoshi Sawa
    • Organizer
      The 7th Asia-Pasific C. elegans Meeting
    • Place of Presentation
      The Friendship Hotel of Beijing
    • Year and Date
      2016-06-25
    • Int'l Joint Research / Invited
    • Data Source
      KAKENHI-PROJECT-16H04797
  • [Presentation] C.elegans 発生時におけるPOP-1/TCF標的遺伝子の核内位置の変化2015

    • Author(s)
      澤 斉
    • Organizer
      第67回日本細胞生物学会大会
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      2015-06-30
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K14514
  • [Presentation] Multiple WNTs regulate polarities of seam cells during asymmetric divisions in C.elegans.2010

    • Author(s)
      Yuko Yamamoto, Hisako Takeshita, Hitoshi Sawa
    • Organizer
      EMBO Conference Series : C. elegans : Development and Gene Expression June
    • Place of Presentation
      Heidelberg. Germany
    • Year and Date
      2010-06-19
    • Data Source
      KAKENHI-PROJECT-19207017
  • [Presentation] A network of multiple Wnts and their receptors synchronizes polarities of epithelial stem cells in C.elegans2010

    • Author(s)
      澤斉
    • Organizer
      European Wnt meeting
    • Place of Presentation
      Stockholm
    • Year and Date
      2010-10-29
    • Data Source
      KAKENHI-PROJECT-19207017
  • [Presentation] Regulation of Asymmetric Cell Division by Wnt Signaling in C.elegans2009

    • Author(s)
      澤斉
    • Organizer
      CDB Symposium "Shape & Polarity"
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-19207017
  • [Presentation] Regulation of asymmetric cell division by Wnt signaling through asymmetric spindle microtubules in C.elegans2009

    • Author(s)
      澤斉
    • Organizer
      国際発生生物学会(Kenji Sugioka and Hitoshi Sawa)
    • Place of Presentation
      エジンバラUK
    • Year and Date
      2009-09-08
    • Data Source
      KAKENHI-PROJECT-19207017
  • [Presentation] Wntによる非対称分裂制御機構2009

    • Author(s)
      澤斉
    • Organizer
      日本生化学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-19207017
  • [Presentation] Life without Wnts; Wnt dependent and independent regulation of beta- catenin by Frizzled in cell polarization2007

    • Author(s)
      澤斉
    • Organizer
      Wnt-Signaling in Development and Disease
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2007-09-14
    • Data Source
      KAKENHI-PROJECT-19207017
  • [Presentation] Life without Wnts:Wnt dependent and independent cell polarization2007

    • Author(s)
      澤 斉
    • Organizer
      Sixteenth International C. elegans Meeting
    • Place of Presentation
      Los Angeles,USA
    • Year and Date
      2007-06-28
    • Data Source
      KAKENHI-PROJECT-19207017
  • [Presentation] Regulation of asymmetric cell division by Wnt signaling

    • Author(s)
      HItoshi Sawa
    • Organizer
      EMBO Workshop pn Wnt signaling
    • Place of Presentation
      Cable Beach Club Resort ブルーム、オーストラリア
    • Year and Date
      2014-10-06 – 2014-10-09
    • Invited
    • Data Source
      KAKENHI-PLANNED-22127005
  • [Presentation] Regulation of asymmetric cell division by Wnt signaling in C. elegans

    • Author(s)
      澤 斉
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Invited
    • Data Source
      KAKENHI-PLANNED-22127005
  • 1.  UENO Naoto (40221105)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  TAKEDA Hiroyuki (80179647)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  KONDO Shigeru (10252503)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  OGURA Toshihiko (60273851)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  MATSUMOTO Takeo (30209639)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  MATSUNO Kenji (60318227)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  NISHIWAKI Kiyoji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  KIMURA Akatsuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  TSUKAHARA Tatsuya
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  ARATA Yukinobu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  柴田 幸政
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  日比 正彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  島田 敦子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  平良 眞規
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  清水 厚志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  佐甲 靖志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  伊原 伸治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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