Hino Keisuke 日野啓輔

… Alternative Names

HINO Keisuke 日野啓輔

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Researcher Number	80228741
Other IDs
Affiliation (Current)	2025: 川崎医科大学, 医学部, 特任研究員
Affiliation (based on the past Project Information) *help	2021 – 2023: 川崎医科大学, 医学部, 特任研究員 2008 – 2021: Kawasaki Medical School, 医学部, 教授 2011 – 2012: 川崎医科大学, 肝胆膵内科学, 教授 2007: Yamaguchi University, Graduate Scliool of Medicine, Professor 2006: 山口大学, 大学院医学系研究科, 教授 2005: Yamaguchi University, Faculty of Medicine, Professor, 医学部, 教授 2003 – 2004: 山口大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related Except Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 酸化ストレス / ミトコンドリア / C型肝炎ウイルス / 鉄 / 活性酸素種 / 肝細胞癌 / トランスジェニックマウス / C型肝炎 / hepcidin / oxidative stress … More / hepatitis C / マイトファジー / autophagy / Parkin / mitophagy / Ｃ型肝炎ウイルス / 活性酸素 / 鉄代謝 / 肝発癌 / 免疫チェックポイント阻害剤 / 解糖系抑制 / 脂肪酸合成 / メタボローム解析 / 免疫担当細胞 / Warburug効果 / 糖代謝 / 2DG-PLGA / 2-depxy-D-glucose / ナノ粒子 / Warburg効果 / がん微小環境 / 腫瘍免疫 / enhancer-binding protein / CCAT / transgenic mice / reactive Oxygen species / iron metabolism / henatocellular carcinoma / CHOP / CCAAT enhancer binding protein / EBP / C / ヘプシジン / animal model / iron / apoptosis / mitochondria / hepatocarcinogenesis / Bcl2ファミリー / HCV / 動物モデル / アポトーシス / リン酸化シグナル / リン酸化 / 肝癌 / ミトコンドリアフェリチン / オートファジー / 細胞内シグナル / エストロゲン / 性差 / 肝発がん / SREBP1 / 鉄過剰 / グリチルリチン / 小胞体ストレス / 肝脂肪化 … More Except Principal Investigator ミトコンドリア / マイトファジー / 酸化ストレス / 肝発癌 / PLGA / 解糖系阻害剤 / 肝細胞癌 / 腫瘍免疫 / ナノ粒子 / 解糖系 / がん / mitophagy / 鉄過剰状態 / バイオマーカー / ミトコンドリアフェリチン / FTMT / HCC / mitochondria / 血管内皮細胞 / 2DG / drug delivery system / 2-Deoxy-D-Glucose / ２DG / 抗腫瘍免疫 / 2DG-PLGA-NP / 2-Deoxy-D-Glucose（2DG） / ドラッグデリバリー / 鉄 / 鉄キレート / NASH / Mitophagy / オートファジー / C型肝炎ウイルス / Parkin / HCV / PolyIC / Hepcidin / C型慢性肝炎 / IFN / MAVS / 鉄過剩状態 / HCVTgM / 小胞体ストレス Less

The study for liver cancer specific glycolysis inhibition and efficiency of cancer immunity using novel drug delivery system
- Principal Investigator
  
  Sohji Nishina
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kawasaki Medical School
Elucidation of the mechanism of hepatocarcinogenesis suppression by mitochondrial ferritin
- Principal Investigator
  
  HARA YUICHI
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kawasaki Medical School
Activation of tumor immunity by metabolic reprogramming in liver cancer microenvironmentPrincipal Investigator
- Principal Investigator
  
  Hino Keisuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kawasaki Medical School
Development of an anticancer therapy against liver cancer using 2-deoxy-D-glucose encapsulated in polymer poly (lactic-co-glycolic acid) nanoparticles
- Principal Investigator
  
  Nishina Sohji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kawasaki Medical School
Iron loss-induced mitophagy via mitochondria ferritin suppresses NASH-related hepatocellular carcinoma
- Principal Investigator
  
  HARA YUICHI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kawasaki Medical School
Investigation of hepatocarcinogenic mechanisms by comprehensive ahalysis of cellular signaling responding to oxidative stressPrincipal Investigator
- Principal Investigator
  
  Hino Keisuke
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kawasaki Medical School
Restoration of mitophagy as a strategy for inhibiting hepatocarcinogenesisPrincipal Investigator
- Principal Investigator
  
  HINO Keisuke
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Kawasaki Medical School
Hepatitis C virus core protein suppresses mitophagy by interacting with parkin in the context of mitochondrial depolarization.
- Principal Investigator
  
  HARA Yuichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Kawasaki Medical School
Analysis of hepatocarcinogenesis based on gender and mitochondrial biogenesisPrincipal Investigator
- Principal Investigator
  
  HINO Keisuke
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kawasaki Medical School
Association of between HCV induced mitochondria dysfunction and viral response by interferon in hepatic iron overloaded
- Principal Investigator
  
  KORENAGA Masaaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Research Institute, International Medical Center of Japan
  Kawasaki Medical School
Crosstalk between iron metabolic disorder and lipid metabolic disorder in hepatocarcinogenesisPrincipal Investigator
- Principal Investigator
  
  HINO Keisuke
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kawasaki Medical School
The role of hepatic mitochondrial function in carcinogenesis of chronic hepatitis C
- Principal Investigator
  
  KORENAGA Masaaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Yamaguchi University
Iron metabolic disorder and hepatocarcinogenesis in hepatitis CPrincipal Investigator
- Principal Investigator
  
  HINO Keisuke
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Yamaguchi University
Oxidative stress and hepatocarcinogenesis in hepatitis CPrincipal Investigator
- Principal Investigator
  
  HINO Keisuke
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Yamaguchi University

[Book] The liver in systemic diseases2016
- Author(s)
  Keisuke Hino, Masaru Harada
- Total Pages
  343
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26293179
[Book] The Liver Cancer Journal2015
- Author(s)
  日野啓輔, 原　裕一
- Total Pages
  6
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-24659377
[Book] C型肝炎の診療を極める基本から最前線まで2014
- Author(s)
  原裕一, 日野啓輔
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-23390201
[Book] 酸化ストレスの医学2014
- Author(s)
  原　裕一　日野啓輔
- Total Pages
  280
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-24659377
[Book] 酸化ストレスの医学2014
- Author(s)
  原裕一, 日野啓輔
- Total Pages
  444
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-26293179
[Book] HEPATOLOGY PRACTICE（第４巻）2014
- Author(s)
  仁科惣治, 日野啓輔
- Total Pages
  340
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-26293179
[Book] HEPATOLOGY　PRACTICE（第３巻）2014
- Author(s)
  原裕一, 日野啓輔
- Total Pages
  321
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-25670374
[Book] HEPATOLOGY　PRACTICE（第３巻）2014
- Author(s)
  原裕一, 日野啓輔
- Total Pages
  321
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-26293179
[Book] 酸化ストレスの医学2014
- Author(s)
  原裕一, 日野啓輔
- Total Pages
  444
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-25670374
[Book] C型肝炎の診療を極める2013
- Author(s)
  原　裕一日野啓輔
- Total Pages
  320
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-24659377
[Book] 診断と治療　ウイルス肝炎の新展開2013
- Author(s)
  原　裕一、日野啓輔
- Total Pages
  190
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-23390201
[Book] 診断と治療　ウイルス肝炎の新展開2013
- Author(s)
  原　裕一、日野啓輔
- Total Pages
  190
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-25670374
[Book] 型慢性肝疾患の鉄代謝異常に対するBCAA顆粒投与の有効性, 酸化ストレスと肝疾患<第8巻>2012
- Author(s)
  是永匡紹、仁科惣治、富山恭行、田中志保、是永圭子、溝上雅史、日野啓輔坪内博仁編集
- Publisher
  株式会社嵯峨野
- Data Source
  KAKENHI-PROJECT-22590750
[Book] 肥満・脂肪肝の栄養管理を向上させる工夫―体組成計・間接熱量計・フリーラジカル測定器を用いた試みー酸化ストレスと肝疾患<第8巻>2012
- Author(s)
  是永匡紹、是永圭子、鈴木淑子、寺本房子、仁科惣治、日野啓輔坪内博仁編集
- Publisher
  株式会社嵯峨野
- Data Source
  KAKENHI-PROJECT-22590750
[Book] わが国における急性肝炎の現状2012
- Author(s)
  日野啓輔
- Total Pages
  180
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-23390201
[Book] 病気の分子形態学2011
- Author(s)
  日野啓輔
- Publisher
  学際企画
- Data Source
  KAKENHI-PROJECT-23390201
[Book] 過剰鉄とミトコンドリア障害が誘導する酸化ストレスはC型肝炎ウイルス増殖を抑制する酸化ストレスと肝疾患第7巻2011
- Author(s)
  是永匡紹,池田正徳,加藤宣之,日野啓輔
- Data Source
  KAKENHI-PROJECT-22590750
[Journal Article] Final Results of TACTICS: A randomized, prospective trial comparing transarterial chemoembolization plus sorafenib to transarterial chemoembolization alone in patients with unresectable hepatocellular carcinoma2022
- Author(s)
  Kudo M, Ueshima K, Ikeda M, Torimura T, Tanabe N, Aikata H, Izumi N, Yamasaki T, Nojiri S, Hino K, Tsumura H, Kuzuya T, Isoda N, Moriguchi M, Aino H, Ido A, Kawabe N, Nakao K, Wada Y, Ogasawara S, Yoshimura K, Okusaka T, Furuse J, Kokudo N, Okita K, Johnson P, Arai Y.
- Journal Title
  
  Liver Cancer
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03644
[Journal Article] CD26/DPP4 as a Therapeutic Target in Nonalcoholic Steatohepatitis Associated Hepatocellular Carcinoma2022
- Author(s)
  Nishina S, Hino K.
- Journal Title
  
  Cancers
  
  Volume: 14 Issue: 2 Pages: 454-454
- DOI
  10.3390/cancers14020454
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03644
[Journal Article] Long-term phlebotomy successfully alleviated hepatic iron accumulation in a ferroportin disease patient with a mutation in SLC40A1: A case report.2021
- Author(s)
  Nishina S, Tomiyama Y, Ikuta K, Tatsumi Y, Toki Y, Kato A, Kato K, Yoshioka N, Sasaki K, Hara Y, Hino K.
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 21(1) Issue: 1 Pages: 111-111
- DOI
  10.1186/s12876-021-01674-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08347, KAKENHI-PROJECT-19H03644, KAKENHI-PROJECT-21K07995
[Journal Article] Importance of HBsAg recognition by HLA molecules as revealed by responsiveness to different hepatitis B vaccines2021
- Author(s)
  Nao Nishida, Masaya Sugiyama, Aiko Sakai, Katsushi Tokunaga, Masashi Mizokami et al.
- Journal Title
  
  Sci Rep
  
  Volume: 11(1) Issue: 1 Pages: 3703-3703
- DOI
  10.1038/s41598-021-82986-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16874, KAKENHI-PROJECT-19H03644, KAKENHI-PROJECT-21K07997
[Journal Article] Correlation of hepatitis C virus-mediated endoplasmic reticulum stress with autophagic flux impairment and hepatocarcinogenesis2021
- Author(s)
  Honma Yuichi、Miyagawa Koichiro、Hara Yuichi、Hayashi Tsuguru、Kusanaga Masashi、Ogino Noriyoshi、Minami Sota、Oe Shinji、Ikeda Masanori、Hino Keisuke、Harada Masaru
- Journal Title
  
  Medical Molecular Morphology
  
  Volume: - Issue: 2 Pages: 108-121
- DOI
  10.1007/s00795-020-00271-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17037, KAKENHI-PROJECT-18K07988, KAKENHI-PROJECT-19H03644, KAKENHI-PROJECT-21K07044, KAKENHI-PROJECT-21K07926, KAKENHI-PROJECT-21K07995
[Journal Article] Nanoparticle-Mediated Delivery of 2-Deoxy-D-Glucose Induces Antitumor Immunity and Cytotoxicity in Liver Tumors in Mice2021
- Author(s)
  Sasaki Kyo、Nishina Sohji、Yamauchi Akira、Fukuda Kotaro、Hara Yuichi、Yamamura Masahiro、Egashira Kensuke、Hino Keisuke
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 11 Issue: 3 Pages: 739-762
- DOI
  10.1016/j.jcmgh.2020.10.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07676, KAKENHI-PROJECT-19H03644, KAKENHI-PROJECT-18K07923, KAKENHI-PROJECT-21K07995
[Journal Article] Iron and liver cancer: an inseparable connection2021
- Author(s)
  Hino Keisuke、Yanatori Izumi、Hara Yuichi、Nishina Sohji
- Journal Title
  
  The FEBS Journal
  
  Volume: - Issue: 24 Pages: 7810-7829
- DOI
  10.1111/febs.16208
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07309, KAKENHI-PROJECT-19H03644, KAKENHI-PROJECT-21K07995
[Journal Article] Reduced Handgrip Strength Predicts Poorer Survival in Chronic Liver Diseases: A Large Multi-Center Study in Japan2021
- Author(s)
  Nishikawa H, Shiraki M, Hiramatsu N, Hata K, Moriya K, Hino K, Koike K.
- Journal Title
  
  Hepatol Res
  
  Volume: 51 Issue: 9 Pages: 957-967
- DOI
  10.1111/hepr.13679
- Data Source
  KAKENHI-PROJECT-19H03644
[Journal Article] Serum miR-379 expression is related to the development and progression of hypercholesterolemia in non-alcoholic fatty liver disease2020
- Author(s)
  Okamoto, K. Koda, M. Okamoto, T. Onoyama, T. Miyoshi, K. Kishina, M. Matono, T. Kato, J. Tokunaga, S. Sugihara, T. Hiramatsu, A. Hyogo, H. Tobita, H. Sato, S. Kawanaka, M. Hara, Y. Hino, K. Chayama, K. Murawaki, Y. Isomoto, H.
- Journal Title
  
  PLoS One
  
  Volume: 15 Issue: 2 Pages: e0219412-e0219412
- DOI
  10.1371/journal.pone.0219412
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03644, KAKENHI-PROJECT-17H06269
[Journal Article] Mitochondrial damage and iron metabolic dysregulation in hepatitis C virus infection2019
- Author(s)
  Hino K, Nishina S, Sasaki K, Hara Y
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 133 Pages: 193-199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09384
[Journal Article] Dipeptidyl Peptidase 4 Inhibitors Reduce Hepatocellular Carcinoma by Activating Lymphocyte Chemotaxis in Mice2019
- Author(s)
  Nishina S, Yamauchi A, Kawaguchi T, Kaku K, Goto M, Sasaki K, Hara Y, Tomiyama Y, Kuribayashi F, Torimura T, Hino K.
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 5 Pages: 115-134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09384
[Journal Article] Randomised, multicentre prospective trial of transarterial chemoembolisation (TACE) plus sorafenib as compared with TACE alone in patients with hepatocellular carcinoma: TACTICS trial2019
- Author(s)
  Kudo, M. Ueshima, K. Ikeda, M. Torimura, T. Tanabe, N. Aikata, H. Izumi, N. Yamasaki, T. Nojiri, S. Hino, K. Tsumura, H. Kuzuya, T. Isoda, N. Yasui, K. Aino, H. Ido, A. Kawabe, N. Nakao, K. Wada, Y. Yokosuka, O. Yoshimura, K. Okusaka, T. Furuse, J. Kokudo, N. Okita, K. Johnson, P. J. Arai, Y. Tactics study group
- Journal Title
  
  Gut
  
  Volume: - Issue: 8 Pages: 1492-1501
- DOI
  10.1136/gutjnl-2019-318934
- NAID
  120006954908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03644
[Journal Article] 特集Ⅱ　肝疾患におけるサルコペニアのメカニズム2019
- Author(s)
  原裕一、日野啓輔
- Journal Title
  
  消化器・肝臓内科　 Gastroenterology & hepatology
  
  Volume: 5 Pages: 92-97
- Data Source
  KAKENHI-PROJECT-16K09384
[Journal Article] Dipeptidyl Peptidase 4 Inhibitors Reduce Hepatocellular Carcinoma by Activating Lymphocyte Chemotaxis in Mice2019
- Author(s)
  Nishina, S. Yamauchi, A. Kawaguchi, T. Kaku, K. Goto, M. Sasaki, K. Hara, Y. Tomiyama, Y. Kuribayashi, F. Torimura, T. Hino, K.
- Journal Title
  
  Cell Mol Gastroenterol Hepatol
  
  Volume: 7 Issue: 1 Pages: 115-134
- DOI
  10.1016/j.jcmgh.2018.08.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03644
[Journal Article] Combinational use of2018
- Author(s)
  Matsumoto A, Nishiguchi S, Enomoto H, Kang JH, Tanaka Y, Shinkai N, Kurosaki M, Enomoto M, Kanda T, Yokosuka O, Yatsuhashi H, Nagaoka S, Okuse C, Kagawa T, Mine T, Takaguchi K, Saito S, Hino K, Ikeda F, Sakisaka S, Morihara D, Miyase S, Tsuge M, Chayama K, Hiramatsu N, Suzuki Y, Murata K, Tanaka E
- Journal Title
  
  J Gastroenterol
  
  Volume: 53 Issue: 2 Pages: 247-257
- DOI
  10.1007/s00535-017-1360-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09448, KAKENHI-PROJECT-26293179, KAKENHI-PROJECT-15H01803, KAKENHI-PROJECT-15K09002
[Journal Article] Key HLA-DRB1-DQB1 haplotypes and role of the BTNL2 gene for response to a hepatitis B vaccine.2018
- Author(s)
  Nishida N, Sugiyama M, Sawai H, Nishina S, Sakai A, Ohashi J, Khor SS, Kakisaka K, Tsuchiura T, Hino K, Sumazaki R, Takikawa Y, Murata K, Kanda T, Yokosuka O, Tokunaga K, Mizokami M
- Journal Title
  
  Hepatology
  
  Volume: 印刷中 Issue: 3 Pages: 848-858
- DOI
  10.1002/hep.29876
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09387, KAKENHI-PROJECT-26293179, KAKENHI-PROJECT-17H04168, KAKENHI-PROJECT-17K09448, KAKENHI-PROJECT-15K08986, KAKENHI-PROJECT-16K19629
[Journal Article] Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts the development of hepatocellular carcinoma in patients with non-alcoholic fatty liver disease.2018
- Author(s)
  Miwa Kawanaka, Yasuyuki Tomiyama, Hideyuki Hyogo, Masahiko Koda, Toshihide Shima, Hiroshi Tobita, Akira Hiramatsu, Ken Nishino, Toshiaki Okamoto, Shuichi Sato, Yuichi Hara, Sohji Nishina, Hirofumi Kawamoto, Kazuaki Chayama, Takeshi Okanoue, Keisuke Hino
- Journal Title
  
  Hepatology Research
  
  Volume: 48 Pages: 521-528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09384
[Journal Article] 肝炎と酸化ストレス2018
- Author(s)
  原　裕一, 日野啓輔
- Journal Title
  
  肝胆膵
  
  Volume: 77 Pages: 643-649
- Data Source
  KAKENHI-PROJECT-16K09384
[Journal Article] 1.Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts the development of hepatocellular carcinoma in patients with nonalcoholic fatty liver disease.2018
- Author(s)
  Miwa Kawanaka, Yasuyuki Tomiyama, Hideyuki Hyogo, Masahiko Koda, Toshihide Shima, Hiroshi Tobita, Akira Hiramatsu, Ken Nishino, Toshiaki Okamoto, Shuichi Sato, Yuichi Hara, Sohji Nishina, Hirofumi Kawamoto, Kazuaki Chayama, Takeshi Okanoue, Keisuke Hino.
- Journal Title
  
  Hepatol Res.
  
  Volume: 1 Issue: 7 Pages: 13054-13054
- DOI
  10.1111/hepr.13054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09384, KAKENHI-PROJECT-26293179
[Journal Article] Sorafenib plus low-dose cisplatin and fluorouracil hepatic arterial infusion chemotherapy versus sorafenib alone in patients with advanced hepatocellular carcinoma (SILIUS): a randomised, open label, phase 3 trial2018
- Author(s)
  Kudo M、Ueshima K、Yokosuka O、Ogasawara S、Obi S、Izumi N、Aikata H、Nagano H、Hatano E、Sasaki Y、Hino K、Kumada T、Yamamoto K、Imai Y、Iwadou S、Ogawa C、Okusaka T、Kanai F、Akazawa K、Yoshimura K、Johnson P、Arai Y
- Journal Title
  
  The Lancet Gastroenterology & Hepatology
  
  Volume: 3 Issue: 6 Pages: 424-432
- DOI
  10.1016/s2468-1253(18)30078-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K12400, KAKENHI-PROJECT-26293179, KAKENHI-PROJECT-18K07922, KAKENHI-PROJECT-18H02798
[Journal Article] Quantitative assessment of liver fibrosis reveals a nonlinear association with fibrosis stage in nonalcoholic fatty liver disease.2018
- Author(s)
  Masugi Y, Abe T, Tsujikawa H, Effendi K, Hashiguchi A, Abe M, Imai Y, Hino K, Hige S, Kawanaka M, Yamada G, Kage M, Korenaga M, Hiasa Y, Mizokami M, Sakamoto M
- Journal Title
  
  Hepatology Communications
  
  Volume: 2 Pages: 58-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09384
[Journal Article] Assessment of hepatic fibrosis with superb microvascular imaging in hepatitis C virus-associated chronic liver diseases2017
- Author(s)
  Koyama, N. Hata, J. Sato, T. Tomiyama, Y. Hino, K
- Journal Title
  
  Hepatol Res
  
  Volume: 47 Issue: 6 Pages: 593-597
- DOI
  10.1111/hepr.12776
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293179, KAKENHI-PROJECT-16K09384
[Journal Article] Quantitative assessment of liver fibrosis reveals a nonlinear association with fibrosis stage in nonalcoholic fatty liver disease.2017
- Author(s)
  Masugi Y, Abe T, Tsujikawa H, Effendi K, Hashiguchi A, Abe M, Imai Y, Hino K, Hige S, Kawanaka M, Yamada G, Kage M, Korenaga M, Hiasa Y, Mizokami M, Sakamoto M
- Journal Title
  
  Hepatol Commun
  
  Volume: 27 Issue: 1 Pages: 58-68
- DOI
  10.1002/hep4.1121
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09388, KAKENHI-PROJECT-26293179, KAKENHI-PROJECT-15K09006, KAKENHI-PROJECT-15K09007
[Journal Article] Acyl/free carnitine ratio is a risk factor for hepatic steatosis after pancreatoduodenectomy and total pancreatectomy2017
- Author(s)
  Nakamura, M. Nakata, K. Matsumoto, H. Ohtsuka, T. Yoshida, K. Tokunaga, S. Hino, K
- Journal Title
  
  Pancreatology
  
  Volume: 17 Issue: 1 Pages: 135-138
- DOI
  10.1016/j.pan.2016.11.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293179
[Journal Article] Assessment of clinical and MRI features of de novo hypervascular HCC using gadoxetic acid-enhanced MRI2017
- Author(s)
  Tamada, T. Korenaga, M. Yamamoto, A. Higaki, A. Kanki, A. Nishina, S. Hino, K. Ito, K
- Journal Title
  
  Hepatol Res
  
  Volume: 47 Issue: 3 Pages: 152-160
- DOI
  10.1111/hepr.12742
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293179, KAKENHI-PROJECT-16K09384
[Journal Article] A Series of microRNA in the Chromosome 14q32.2 Maternally Imprinted Region Related to Progression of Non-Alcoholic Fatty Liver Disease in a Mouse Model2016
- Author(s)
  Okamoto K, Koda M, Okamoto T, Onoyama T, Miyoshi K, Kishina M, Kato J, Tokunaga S, Sugihara TA, Hara Y, Hino K, Murawaki Y
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 5 Pages: e0154676-e0154676
- DOI
  10.1371/journal.pone.0154676
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293179
[Journal Article] 集学的治療で長期予後が得られた大動脈周囲リンパ節転移・肝転移を伴う進行胆嚢癌の1例2016
- Author(s)
  上野太輔, 中島洋, 中島義博, 吉田浩司, 日野啓輔, 伊禮功, 中村雅史
- Journal Title
  
  胆道
  
  Volume: 30(2) Pages: 241-250
- NAID
  130005157395
- Data Source
  KAKENHI-PROJECT-16K09384
[Journal Article] L-Carnitine Supplementation Improved Hepatic Steatosis After Pancreatectomy2016
- Author(s)
  Nakamura M, Matsumoto H, Nakashima H, Ando Y, Hirai T, Yoshida K, Hino K
- Journal Title
  
  Pancreas
  
  Volume: 45 Issue: 3 Pages: e7-e9
- DOI
  10.1097/mpa.0000000000000508
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293179
[Journal Article] 【ミトコンドリアダイナミクスと疾患】肝疾患におけるマイトファジーの意義2016
- Author(s)
  原裕一, 日野啓輔
- Journal Title
  
  細胞
  
  Volume: 38(11) Pages: 534-537
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K09384
[Journal Article] Genome-Wide Association Study Identifies ZNF354C Variants Associated with Depression from Interferon-Based Therapy for Chronic Hepatitis C2016
- Author(s)
  Matsunami K, Nishida N, Kaneko N, Ikeo K, Licht Toyo-oka, Takeuchi H, Matsuura K, Tamori A, Nomura H, Yoshiji H, Imamura M, Masaki N, Hayakawa T, Ide T, Shimada N, Ikeda F, Hino K, Nishiguchi S, Okuse C, Nojiri S, Sawamoto K, Tokunaga K, Joh T, Tanaka
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 10 Pages: 1-18
- DOI
  10.1371/journal.pone.0164418
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01217, KAKENHI-PUBLICLY-15H01384, KAKENHI-PROJECT-26250019, KAKENHI-PROJECT-26293179
[Journal Article] Understanding of HLA-conferred susceptibility to chronic hepatitis B infection requires HLA genotyping-based association analysis.2016
- Author(s)
  N. Nishida (他37名, 山本31番目)
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 24767-24767
- DOI
  10.1038/srep24767
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K05577, KAKENHI-PROJECT-15K08986, KAKENHI-PROJECT-26293179, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26293181, KAKENHI-PROJECT-16K15426, KAKENHI-PROJECT-16K09387, KAKENHI-PROJECT-15K15483
[Journal Article] Emergent laparoscopic cholecystectomy for acute acalculous cholecystitis revisited2016
- Author(s)
  Ueno, D. Nakashima, H. Higashida, M. Yoshida, K. Hino, K. Irei, I. Moriya, T. Matsumoto, H. Hirai, T. Nakamura, M
- Journal Title
  
  Surg Today
  
  Volume: 46 Issue: 3 Pages: 309-312
- DOI
  10.1007/s00595-015-1173-8
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293179
[Journal Article] Branched-chain amino acids reduce hepatic iron accumulation and oxidative stress in hepatitis C virus polyprotein-expressing mice.2015
- Author(s)
  Korenaga M, Nishina S, Korenaga K, Tomiyama Y, Yoshioka N, Hara Y, Sasaki Y, Shimonaka Y, Hino K.
- Journal Title
  
  Liver Int.
  
  Volume: 35 Issue: 4 Pages: 1303-14
- DOI
  10.1111/liv.12675
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24659377, KAKENHI-PROJECT-25670374, KAKENHI-PROJECT-25461019, KAKENHI-PROJECT-26293179
[Journal Article] Association between Wisteria floribunda agglutinin-positive Mac-2 binding protein and the fibrosis stage of non-alcoholic fatty liver disease2015
- Author(s)
  Abe M, Miyake T, Kuno A, Imai Y, Sawai Y, Hino K, Hara Y, Hige S, Sakamoto M, Yamada G, Kage M, Korenaga M, Hiasa Y, Mizokami M, Narimatsu H
- Journal Title
  
  J Gastroenterol
  
  Volume: 50 Issue: 7 Pages: 776-784
- DOI
  10.1007/s00535-014-1007-2
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09007, KAKENHI-PROJECT-26293179
[Journal Article] Effects of HLA-DPB1 genotypes on chronic hepatitis B infection in Japanese individuals.2015
- Author(s)
  N. Nishida, J. Ohashi, M. Sugiyama, T. Tsuchiura, K. Yamamoto, K. Hino, M. Honda, S. Kaneko, H. Yatsuhashi, K. Koike, O. Yokosuka, E. Tanaka, A. Taketomi, M. Kurosaki, N. Izumi, N. Sakamoto, Y. Eguchi, T. Sasazuki, K. Tokunaga, and M. Mizokami
- Journal Title
  
  Tissue Antigens
  
  Volume: 5 Issue: 6 Pages: 406-412
- DOI
  10.1111/tan.12684
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K05577, KAKENHI-PROJECT-26670375, KAKENHI-PROJECT-26293179, KAKENHI-PROJECT-25291103
[Journal Article] Fibroblast activation protein-alpha-expressing fibroblasts promote the progression of pancreatic ductal adenocarcinoma2015
- Author(s)
  Kawase T, Yasui Y, Nishina S, Hara Y, Yanatori I, Tomiyama Y, Nakashima Y, Yoshida K, Kishi F, Nakamura M, Hino K
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 15 Issue: 1 Pages: 109-109
- DOI
  10.1186/s12876-015-0340-0
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293179
[Journal Article] Genome-wide association study identifies a PSMD3 variant associated with neutropenia in interferon-based therapy for chronic hepatitis C.2015
- Author(s)
  Iio E, Matsuura K, Nishida N, Maekawa S, Enomoto N, Nakagawa M, Sakamoto N, Yatsuhashi H et al.
- Journal Title
  
  Hum Genet
  
  Volume: 134 Issue: 3 Pages: 279-289
- DOI
  10.1007/s00439-014-1520-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-24590958, KAKENHI-PROJECT-24590965, KAKENHI-PROJECT-26670375, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26670378, KAKENHI-PROJECT-26293179
[Journal Article] Mitochondrial reactive oxygen species as a mystery voice in hepatitis C2014
- Author(s)
  Hino K, Hara Y, Nishina S
- Journal Title
  
  Hepatol Res
  
  Volume: 44 Issue: 2 Pages: 123-32
- DOI
  10.1111/hepr.12247
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390201, KAKENHI-PROJECT-24659377, KAKENHI-PROJECT-25670374, KAKENHI-PROJECT-26293179
[Journal Article] New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia.2014
- Author(s)
  Nishida N, Sawai H, Kashiwase K, Minami M, Sugiyama M, Tanak Y, Kurosaki M, Asahina Y, Izumi N, Orito E, Hiasa Y, Honda M, Kaneko S, Mita E, Suzuki K, Hino K, Tanaka E, Mochida S, Mawatari Y, Ohashi J, Kawashima M, Tokunaga K, Mizokami, et al M
- Journal Title
  
  PLOS One
  
  Volume: 9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670374
[Journal Article] Hepatic oxidative stress in ovariectomized transgenic mice expressing the hepatitis C virus polyprotein is augmented through suppression of AMPK/PGC-1alpha signaling2014
- Author(s)
  Tomiyama Y, Nishina S, Hara Y, Kawase T, Hino K
- Journal Title
  
  Hepatol Res
  
  Volume: (in press) Issue: 10 Pages: 229-39
- DOI
  10.1111/hepr.12254
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390201, KAKENHI-PROJECT-24659377, KAKENHI-PROJECT-25670374, KAKENHI-PROJECT-26293179
[Journal Article] Hepatitis C virus core protein suppresses mitophagy by interacting with parkin in the context of mitochondrial depolarization.2014
- Author(s)
  Hara Y, Yanatori I, Ikeda M, Kiyokage E, Nishina S, Tomiyama Y, Toida K, Kishi F, Kato N, Imamura M, Chayama K, Hino K.
- Journal Title
  
  Am J Pathol. 2014
  
  Volume: 184 Issue: 11 Pages: 3026-39
- DOI
  10.1016/j.ajpath.2014.07.024
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24659377, KAKENHI-PROJECT-25670374, KAKENHI-PROJECT-26293179, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-25293110
[Journal Article] New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia.2014
- Author(s)
  Nishida N, Sawai H, Kashiwase K, Minami M, Sugiyama M, Seto WK, Yuen MF, Posuwan N, Poovorawan Y, Ahn SH, Han KH, Matsuura K, Tanaka Y, Kurosaki M, Asahina Y, Izumi N, Yamamoto K, Sakaida I, Murawaki Y, Itoh Y, Tamori A, Orito E, Honda M, Kaneko S, Mita E, Hino K, Tokunaga K, Mizokami M, et al
- Journal Title
  
  PLOS One
  
  Volume: 9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390201
[Journal Article] New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia.2014
- Author(s)
  Nishida N, Sawai H, Kashiwase K, Minami M, Sugiyama M, Seto WK, Yuen MF, Posuwan N, Poovorawan Y, Ahn SH, Han KH, Matsuura K, Tanaka Y, Kurosaki M, Asahina Y, Izumi N, Kang JK, （省略）, Tokunaga K, and Mizokami M
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 2 Pages: e86449-e86449
- DOI
  10.1371/journal.pone.0086449
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22133008, KAKENHI-PROJECT-23390117, KAKENHI-PROJECT-23390201, KAKENHI-PROJECT-23590985, KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-24590960, KAKENHI-PROJECT-24590980, KAKENHI-PROJECT-24790728, KAKENHI-PROJECT-25293169, KAKENHI-PROJECT-25461010, KAKENHI-PROJECT-25670366, KAKENHI-PROJECT-25860574, KAKENHI-PROJECT-25870178, KAKENHI-PROJECT-26461027, KAKENHI-PROJECT-26670378, KAKENHI-PROJECT-25291103
[Journal Article] Mitochondrial reactive oxygen species as a mystery voice in hepatits C2014
- Author(s)
  Hino K, Hara Y, Nishina S
- Journal Title
  
  Heparol Res
  
  Volume: 44 Pages: 123-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390201
[Journal Article] Clinical usefulness of non-protein respiratory quotient measurement in non-alcoholic fatty liver disease.2013
- Author(s)
  Keiko Korenaga , Masaaki Korenaga, Fusako Teramoto, Toshiko Suzuki,Sohoji Nishina, Kyo Sasaki, Yoshihiro Nakashima,Yasuyuki Tomiyama, Naoko Yoshioka, Yuichi Hara, Takuya Moriya, Keisuke Hino
- Journal Title
  
  Hepatol Res
  
  Volume: 43 Pages: 1284-1294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659377
[Journal Article] Hepatic oxidative stress in ovariectomized transgenic mice expression the hepatitis C virus polyprotein is augmented through suppression of adenosine monophosphate-activated protein kinase/proliferator-activated receptor gamma co-activator 1 alpha signaling.2013
- Author(s)
  Yasuyuki Tomiyama Sohoji Nishina Yuichi hara Keisuke Hino
- Journal Title
  
  Hepatol Res
  
  Volume: １４ Pages: 1-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659377
[Journal Article] Clinical usefulness of non-protein respiratory quotient measurement in non-alcoholic fatty liver disease2013
- Author(s)
  Korenaga K, Korenaga M, Hino K, 他9名(12番目)
- Journal Title
  
  Hepatol Res
  
  Volume: 43 Pages: 1284-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390201
[Journal Article] Clinical usefulness of non-protein respiratory quotient measurement in non-alcoholic fatty liver disease2013
- Author(s)
  Korenaga K1, Korenaga M, Teramoto F, Suzuki T, Nishina S, Sasaki K, Nakashima Y, Tomiyama Y, Yoshioka N, Hara Y, Moriya T, Hino K.
- Journal Title
  
  Hepatol Res.
  
  Volume: 43 Issue: 12 Pages: 1284-1294
- DOI
  10.1111/hepr.12095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461019, KAKENHI-PROJECT-25670374
[Journal Article] Iron metabolic disorder in chronic hepatitis C: Mechanisms and relevance to hepatocarcinogenesis2013
- Author(s)
  Hino K, Nishina S, Hara Y
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 28 Suppl 4 Issue: S4 Pages: 93-8
- DOI
  10.1111/jgh.12243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390201, KAKENHI-PROJECT-24659377, KAKENHI-PROJECT-25670374
[Journal Article] Iron metabolic disorder in chronic hepatitis C:Mechanisms and relevance to hepatocarcinogenesis.2013
- Author(s)
  Keisuke Hino, Sohoji Nishina, Yuichi hara
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 28 Pages: 93-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659377
[Journal Article] Iron metabolic disorder in chronic hepatitis C. Mechanisms and relevance to hepatocarcinogenesis2013
- Author(s)
  Hino K, Nishina S, Hara Y
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 28 Suppl 4 Pages: 93-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390201
[Journal Article] Risk factors for survival and the development of hepatocellular carcinoma in patients with primary biliary cirrhosis.2013
- Author(s)
  Tomiyama Yasuyuki,Kazuyuki Takenaka ,Takahiro Kodama,Miwa Kawanaka , Kyo Sasaki,Sohoji Nishina , Naoko Yoshioka, Yuichi Hara Y, Keisuke Hino
- Journal Title
  
  Hepatol Res
  
  Volume: 52 Pages: 1553-1559
- NAID
  130003365701
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659377
[Journal Article] Treatment of nonalcoholic steatohepatitis with vitamins E and C: a pilot study2013
- Author(s)
  Kawanaka M, Nishino K, Suehiro M, Goto D, Urata N, Oka T, Kawamoto H, Nakamura H, Yodoi J, Hino K, Yamada G
- Journal Title
  
  Hepatic Medicine: Evidence and Research
  
  Volume: 5 Pages: 11-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670374
[Journal Article] Risk factors for survival and the development of hepatocellular carcinoma in patients with primary biliary cirrhosis2013
- Author(s)
  Tomiyama Y, Takenaka K, Kodama T, Kawanaka M, sasaki K, Nishina S, Yoshioka N, Hara Y, Hino K
- Journal Title
  
  Intern Med
  
  Volume: 52 Pages: 1553-9
- NAID
  130003365701
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390201
[Journal Article] First jejunal vein oriented mesenteric excision for pancreatoduodenectomy2013
- Author(s)
  Nakamura M, Nakashima H, Tsutsumi K, Matsumoto H, Muta Y, Ueno D, Yoshida K, Hino K, Urakami A, Tanaka M
- Journal Title
  
  J Gastroenterol
  
  Volume: 48 Issue: 8 Pages: 989-95
- DOI
  10.1007/s00535-012-0697-6
- NAID
  10031195125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390201, KAKENHI-PROJECT-25670374
[Journal Article] Risk factors for survival and the development of hepatocellular carcinoma in patients with primary biliary cirrhosis2013
- Author(s)
  Tomiyama Y, Takenaka K, Kodama T, Kawanaka M, sasaki K, Nishina S, Yoshioka N, Hara Y, Hino K
- Journal Title
  
  Intern Med
  
  Volume: 52 Pages: 1553-9
- NAID
  130003365701
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670374
[Journal Article] Treatment of nonalcoholic steatohepatitis with vitamins E and C: a pilot study2013
- Author(s)
  Kawanaka M, Nishino K, Suehiro M, Goto D, Urata N, Oka T, Kawamoto H, Nakamura H, Yodoi J, Hino K, Yamada G
- Journal Title
  
  Hepatic Medicine: Evidence and Research
  
  Volume: 5 Pages: 11-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390201
[Journal Article] HCV感染における鉄過剰異常、酸化ストレスと分岐鎖アミノ酸2012
- Author(s)
  是永匡紹、日野啓輔, 溝上雅史
- Journal Title
  
  肝がん・肝硬変に対する栄養療法の新時代 (市田隆文、平野克治監・編集, アークメディア東京)
  
  Pages: 16-19
- Data Source
  KAKENHI-PROJECT-22590750
[Journal Article] Iron metabolic disorder: insights from recent evidence2012
- Author(s)
  Hino Keisuke
- Journal Title
  
  Cin J Gastroenterol
  
  Volume: 5 Issue: 4 Pages: 251-256
- DOI
  10.1007/s12328-012-0323-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390201
[Journal Article] Iron metabolic disorder: insights from recent evidence2012
- Author(s)
  Hino　Keisuke
- Journal Title
  
  Cin J Gastroenterol
  
  Volume: 5 Pages: 251-256
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659377
[Journal Article] Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.2012
- Author(s)
  Nishida N, Asahina Y, Mizokami M et al
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 6 Pages: 1-8
- DOI
  10.1371/journal.pone.0039175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-23390201, KAKENHI-PROJECT-23590985, KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-24590960, KAKENHI-PROJECT-24790728, KAKENHI-PROJECT-24890058, KAKENHI-PLANNED-22133008, KAKENHI-PROJECT-221S0002
[Journal Article] 症例13 メトホルミンと瀉血が有効だった症例.2012
- Author(s)
  是永匡紹, 是永圭子, 日野啓輔, 溝上雅史
- Journal Title
  
  症例に学ぶNASH/NAFLDの診断と治療―臨床で役立つ症例 (岡上武, 米田正人, 江口有一郎, 角田圭雄, 中島淳編集, 診断と治療社, 東京)
  
  Volume: 32
- Data Source
  KAKENHI-PROJECT-22590750
[Journal Article] Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C2011
- Author(s)
  Tanaka Y, Kurosaki M, Hino K, 他19名
- Volume
  20
- Pages
  3507-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390201
[Journal Article] The rs80999 polymorphism, determined by a suitable genotyping method, is a better predictor for response to pegylated interferon-α/ribavirin therapy in Japanese patients than other SNPs associated with IL28B.2011
- Author(s)
  Ito K, Higami K, Masaki N, Sugiyama M, Mukaide M, Saito H, Aoki Y, sato Y, Imamura M, Murata K, Nomura H, Hige S, Adachi H, Hino K, Yatsuhashi H, Orito E, Kani S, Tanaka Y, Mizokami M
- Journal Title
  
  J Clin Microbiol 49
  
  Pages: 1853-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590782
[Journal Article] Recommendation of lamivudine-to-entecavir switching treatment in chronic hepatitis B responders : Randomized controlled study.2011
- Author(s)
  Matsuura K, Tanaka Y, Kusakabe A, Hige S, Inoue J, Komatsu M, Kuramitsu T, Hirano K, Ohno T, Hasegawa I, Kobashi H, Hino K, Hiasa Y, Nomura H, Sugauchi F, Nojiri S, Joh T, Mizokami M
- Journal Title
  
  Hepatol Res 41
  
  Pages: 505-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590782
[Journal Article] A glycyrrhizin-containing preparation reduces hepatic steatosis induced by hepatitis C virus protein and iron in mice2011
- Author(s)
  Korenaga M, Hidaka I, Nishina S, Sakai A, Shinozaki A, Gondo T, Furutani T, Kawano H< sakaida I, Hino K
- Journal Title
  
  Liver Int
  
  Volume: 31 Pages: 552-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390201
[Journal Article] Type I interferon receptor in peripheral blood mononuclear cells may predict response to intraarterial 5-fluorouracil/interferon combination therapy for advanced hepatocellular carcinoma-a pilot study-2011
- Author(s)
  Tomiyama Y, Yoshioka N, Yanai Y, Kawase T, Nishina S, Hara Y, Yoshida K, Korenaga K, Korenaga M, Hino K
- Journal Title
  
  Hepat Med 3
  
  Pages: 45-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590782
[Journal Article] Focal nodular hyperplasia-like nodule with reduced expression of organic anion transporter 1B3 in alcoholic liver cirrhosis.2011
- Author(s)
  Doi N, Tomiyama Y, Kawase T, Nishina S, Yoshioka N, Hara Y, Yoshida K, Korenaga K, Korenaga M, Moriya T, Urakami A, Nakashima O, Kojiro M, Hino K
- Journal Title
  
  Intern Med 50
  
  Pages: 1193-9
- NAID
  130000770471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590782
[Journal Article] A glycyrrhizin-containing preparation reduces hepatic steatosis induced by hepatitis C virus protein and iron in mice.2011
- Author(s)
  Korenaga M, Hidaka I, Hino K, 他7名
- Journal Title
  
  Liver Int
  
  Volume: 31(4) Pages: 552-60
- Data Source
  KAKENHI-PROJECT-22590750
[Journal Article] A glycyrrhizin-containing preparation reduces hepatic steatosis induced by hepatitis C virus protein and iron in mice.2011
- Author(s)
  Korenaga M, Hidaka I, Nishina S, Sakai A, Shinozaki A, Gondo T, Furutani T, Kawano H, Sakaida I, Hino K
- Journal Title
  
  Liver Int 31
  
  Pages: 552-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590782
[Journal Article] Hepatitis C virus protein and iron overload induce hepatic steatosis through the unfolded protein response in mice2010
- Author(s)
  Nishina S, Korenaga M, Hino K, 他6名
- Journal Title
  
  Liver Int
  
  Volume: 30(5) Pages: 683-92
- Data Source
  KAKENHI-PROJECT-22590750
[Journal Article] Management of hepatitis C ; Report of the Consensus Meeting at the 45th Annual Meeting of the Japan Society of Hepatology (2009).2010
- Author(s)
  Namiki I, Nishiguchi S, Hino K, Suzuki F, Kumada H, Itoh Y, Asahina Y, Tamori A, Hiramatsu N, Hayashi N, Kudo M
- Journal Title
  
  Hepatol Res 40
  
  Pages: 347-68
- NAID
  10027291334
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590782
[Journal Article] Hepatitis C virus protein and iron overload induce hepatic steatosis through the unfolded protein response in mice2010
- Author(s)
  Nishina S, Korenaga M, Hino K, et al.
- Journal Title
  
  Liver Int 30
  
  Pages: 683-692
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590782
[Journal Article] Molecular typing of Bartonella henselae DNA extracted from human clinical specimens and cat isolates in Japan.2010
- Author(s)
  Yanagihara M, Tsuneoka H, Hoshide S, Ishido E, Umeda A, Tsukahara M, Nojima J, Ichihara K, Hino K, Hirai I, Yamamoto Y
- Journal Title
  
  FEMS Immunol Med Microbiol 60
  
  Pages: 44-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590782
[Journal Article] Hepatitis C virus protein and iron overload induce hepatic steatosis through the unfolded protein response in mice.2010
- Author(s)
  Nishina S, Korenaga M, Hidaka I, Shinozaki A, Sakai A, Gondo T, Tabuchi M, Kishi F, Hino K
- Journal Title
  
  Liver Int 30
  
  Pages: 683-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590782
[Journal Article] Distribution of hepatitis B virus genotypes among patients with chronic infection in Japan shifting toward an increase genotype A.2009
- Author(s)
  Matsuura K, Tanaka Y, Hino K, et al.
- Journal Title
  
  J Clin Microbial 47
  
  Pages: 1476-1483
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590782
[Journal Article] Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C.2009
- Author(s)
  Tanaka Y, Nsihsida N, Sugiyama M, Kurosaki M, Matsuura K, Sakamoto N, Nakagawa M, Korenaga M, Hino K, Hige S, Ito Y, Mita Y, Tanaka E, Mochida S, Murawaki Y, Honda M, Sakai A, Hiasa Y, Nishiguchi S, Koike A, Sakaida I, Imamura M, Ito K, Yano K, Masaki N, Sugauchi F, Izumi N, Tokunaga K, Mizokami M
- Journal Title
  
  Nat Genet 41
  
  Pages: 1105-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590782
[Journal Article] Distribution of hepatitis B virus genotypes among patients with chronic infection in Japan shifting toward an increase of genotype A.2009
- Author(s)
  Matsuura K, Tanaka Y, Hige S, Yamada G, Murawaki Y, Komatsu M, Kuramitsu T, Kawata S, Tanak E, Izumi N, Okuse C, Kakumu S, Okanoue T, Hino K, Hiasa Y, Sata M, Maeshiro T, Sugauchi F, Nojiri S, Joh T, Miyakawa Y, Mizokami M
- Journal Title
  
  J Clin Microbiol 47
  
  Pages: 1476-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590782
[Journal Article] Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C2009
- Author(s)
  Tanaka Y, Nishida N, Hino K, et al.
- Journal Title
  
  Nat Genet 41
  
  Pages: 1105-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590782
[Journal Article] Direct cytopathic effects of particular hepatitis B virus genotypes in severe combined immunodeficiency transgenic with urokinase- type plasminogen activator mouse with human hepatocytes2009
- Author(s)
  Sugiyama M, Tanaka Y, Hino K, et al.
- Journal Title
  
  Gastroenterology 136
  
  Pages: 652-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590782
[Journal Article] Direct cytopathic effects of particular hepatitis B virus genotypes in severe Control combined immunodeficiency transgenic with urokinase-type plasminogen activator mouse with human hepatocytes.2009
- Author(s)
  Sugiyama M, Tanaka Y, Kurbanov F, Maruyama I, Shimada T, Takahashi S, Shirai T, Hino K, Sakaida I, Mizokami M
- Journal Title
  
  Gastroenterology 136
  
  Pages: 652-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590782
[Journal Article] Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription.2008
- Author(s)
  Nishina S, Hino K, Korenaga M, Vecchi C, Pietrangelo A, Mizukami Y, Furutani T, Sakai A, Okuda M, Hidak I, Okita K, Sakaida I
- Journal Title
  
  Gastroenterology 134
  
  Pages: 226-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590782
[Journal Article] Mitochondrial electron transport inhibition in full genomic hepatitis C virus replicon cells is restored by reducing viral replication.2008
- Author(s)
  Ando M, Korenaga M, Hino K, et al
- Journal Title
  
  Liver Int 28
  
  Pages: 1158-1166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590782
[Journal Article] Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription2008
- Author(s)
  Nishina S, Hino K, Korenaga M, 他9名
- Journal Title
  
  Gastroenterology 34(1)
  
  Pages: 226-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590769
[Journal Article] Mitochondrial electron transport inhibition in full genomic hepatitis C virus replicon cells is restored by reducing viral replication Liver Int2008
- Author(s)
  Ando M, Korenaga M, Hino K, 他8名
- Journal Title
  
  28(8)
  
  Pages: 1158-66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590769
[Journal Article] Validating a Markov model of treatment for hepatitis C virus-related hepatocellular carcinoma.2008
- Author(s)
  Ishida H, Wong JB, Hino K, Kurikawa F, Nishina S, Sakaida I, Okita K, Tamesa T, Oka M, Torimura T, Sata M, Takahashi S, Chayama K, Inoue Y
- Journal Title
  
  Methods Inf Med 47
  
  Pages: 529-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590782
[Journal Article] Validating a Markov model of treatment for hepatitis C virus-related hepatocellular carcinoma.2008
- Author(s)
  Ishida H, Wong BJ, Hino K, et al.
- Journal Title
  
  Methods Inf Med 47
  
  Pages: 529-540
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590782
[Journal Article] Mitochondrial electron transport inhibition in full genomic hepatitis C virus replicon cells is restored by reducing viral replication.2008
- Author(s)
  Ando M, Korenaga M, Hino K, Ikeda M, Kato N, Nishina S, Hidaka I, Sakaida I
- Journal Title
  
  Liver Int 28
  
  Pages: 1158-66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590782
[Journal Article] Stronger Neo-Minophagen C^<TM>, a glycyrrhizin-containing preparation, protects liver against carbon tetrachloride-induced oxidative stress in transgenic mice expressing the hepatitis C virus polyprotein2007
- Author(s)
  Hidaka I, Hino K, Korenaga M, 他5名
- Journal Title
  
  Liver Int 27
  
  Pages: 845-53
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590769
[Journal Article] α-Tocopherol and ascorbic acid attenuates the ribavirin-induced decrease of eicosapentaenoic acid in erythrocyte membrane in chronic hepatitis C patients.2006
- Author(s)
  Hino K
- Journal Title
  
  J Gastroenterol Hepatol (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590653
[Journal Article] Alpha-tocopherol and ascorbic acid attenuates the ribavirin-induced decrease of eicosapentaenoic acid in erythrocyte membrane in chronic hepatitis C patients.2006
- Author(s)
  Hino K
- Journal Title
  
  J Gastroenterol Hepatol 21
  
  Pages: 1269-75
- Data Source
  KAKENHI-PROJECT-18590736
[Journal Article] α-Tocopherol and ascorbic acid attenuates the ribavirin-induced decrease of eicosapentaenoic acid in erythrocyte membrane in chronic hepatitis C patients.2006
- Author(s)
  Hino K.
- Journal Title
  
  J Gastroenterol Hepatol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590653
[Journal Article] α-Tocopherol and ascorbic acid attenuates the ribavirin-induced decrease of eicosapentaenoic acid in erythrocyte membrane in chronic hepatitis C patients.
- Author(s)
  Hino K
- Journal Title
  
  J Gastroenterol Hepatol (in press)
- Data Source
  KAKENHI-PROJECT-15590653
[Patent] ケモカイン産生促進剤、免疫チェックポイント阻害剤抵抗性癌治療薬及び抗腫瘍免疫賦活剤2020
- Inventor(s)
  日野啓輔、仁科惣治、佐々木　恭、福田宏太郞
- Industrial Property Rights Holder
  日野啓輔、仁科惣治、佐々木　恭、福田宏太郞
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19H03644
[Patent] 医薬組成物及び腫瘍免疫促進剤2020
- Inventor(s)
  日野啓輔、仁科惣治、佐々木　恭、福田宏太郞
- Industrial Property Rights Holder
  日野啓輔、仁科惣治、佐々木　恭、福田宏太郞
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-19H03644
[Patent] ケモカイン産生促進剤、免疫チェックポイント阻害剤抵抗性癌治療薬及び抗腫瘍免疫賦活剤2019
- Inventor(s)
  佐々木　恭、仁科惣治、日野啓輔
- Industrial Property Rights Holder
  佐々木　恭、仁科惣治、日野啓輔
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-048743
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-19H03644
[Patent] ケモカイン産生促進剤、免疫チェックポイント阻害剤抵抗性癌治療薬及び抗腫瘍免疫賦活剤」2019
- Inventor(s)
  日野啓輔、仁科惣治、佐々木恭、山内明
- Industrial Property Rights Holder
  日野啓輔、仁科惣治、佐々木恭、山内明
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-048743
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18K07923
[Patent] 肝細胞癌の予防又は治療のための医薬2019
- Inventor(s)
  日野啓輔
- Industrial Property Rights Holder
  川崎学園
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-515497
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-16K09384
[Patent] 医薬組成物及び腫瘍免疫活性促進剤2019
- Inventor(s)
  仁科　惣治日野　啓輔佐々木　恭福田　宏太郎
- Industrial Property Rights Holder
  仁科　惣治日野　啓輔佐々木　恭福田　宏太郎
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Acquisition Date
  2021
- Data Source
  KAKENHI-PROJECT-19H03644
[Patent] 肝細胞癌予防のための治療と医薬2017
- Inventor(s)
  日野啓輔
- Industrial Property Rights Holder
  川崎学園
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Acquisition Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-16K09384
[Patent] 肝細胞癌の予防又は治療のための医薬2015
- Inventor(s)
  仁科惣治、日野啓輔、後藤守兄、秦　克美
- Industrial Property Rights Holder
  仁科惣治、日野啓輔、後藤守兄、秦　克美
- Industrial Property Rights Type
  特許
- Filing Date
  2015-04-27
- Data Source
  KAKENHI-PROJECT-26293179
[Patent] C型慢性肝炎治療効果予測のための検査方法及び検査用キット2012
- Inventor(s)
  加藤宣之, 池田正徳, 是永匡紹, 日野啓輔
- Industrial Property Rights Holder
  国立大学法人岡山大学, 学校法人川崎学園
- Industrial Property Rights Type
  特許
- Acquisition Date
  2012-08-31
- Data Source
  KAKENHI-PROJECT-23390201
[Patent] C型慢性肝炎治療効果予測のための検査方法及び検査用キット2011
- Inventor(s)
  加藤宣之、池田正徳、是永匡紹、日野啓輔
- Industrial Property Rights Holder
  加藤宣之、池田正徳、是永匡紹、日野啓輔
- Industrial Property Rights Type
  特許
- Filing Date
  2011-04-27
- Acquisition Date
  2012-08-31
- Data Source
  KAKENHI-PROJECT-23390201
[Presentation] 高齢者に対する低侵襲的肝細胞癌薬物療法としての近赤外線応答型薬物送達システム開発2023
- Author(s)
  佐々木恭、仁科惣治、日野啓輔
- Organizer
  第59回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-21K07925
[Presentation] 肝がん局所環境に高効率で薬剤放出を可能とする近赤外線応答型薬物送達システム開発2023
- Author(s)
  仁科惣治、佐々木恭、日野啓輔
- Organizer
  第109回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-21K07925
[Presentation] A near-infrared-modulated system enabling efficient delivery of glucose derivative as a new therapeutic strategy for liver cancer2023
- Author(s)
  佐々木恭、新井敏、仁科惣治、日野啓輔
- Organizer
  AASLD2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07925
[Presentation] 抗腫瘍免疫活性化作用を有するがん選択的解糖系謝阻害剤による肝がん治療開発2022
- Author(s)
  仁科惣治、日野啓輔
- Organizer
  58回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-21K07925
[Presentation] HEPATIC MITOPHAGY RESTORES MITOCHONDRIAL FUNCTION IN SKELETAL MUSCLE VIA REDUCTION OF SELENOPROTEIN P SECRETION IN NASH-RELATED HEPATOCARCINOGENIC MICE2022
- Author(s)
  仁科惣治、佐々木恭、日野啓輔
- Organizer
  American Association for the Study of Liver Diseases(AASLD) Annual Meeting（国際学会）
- Data Source
  KAKENHI-PROJECT-21K07925
[Presentation] 解糖系を標的とした肝がん特異的薬剤送達システムの開発2022
- Author(s)
  仁科惣治、日野啓輔
- Organizer
  JDDW 2022（第30回日本消化器関連学会週間）
- Data Source
  KAKENHI-PROJECT-21K07925
[Presentation] がん特異的解糖系阻害剤による腫瘍免疫活性化を標的とした肝がん治療戦2021
- Author(s)
  仁科惣治、日野啓輔
- Organizer
  JDDW 2021（第29回日本消化器関連学会週間）
- Data Source
  KAKENHI-PROJECT-21K07925
[Presentation] Study of antitumor immunity activation based on cancer cell-specific glycolytic inhibition2021
- Author(s)
  仁科惣治、佐々木恭、日野啓輔
- Organizer
  American Association for the Study of Liver Diseases(AASLD) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07925
[Presentation] がん特異的解糖系阻害剤による肝細胞癌治療応用と免疫賦活化機構の解明2021
- Author(s)
  仁科惣治、日野啓輔
- Organizer
  第107回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19H03644
[Presentation] 肝細胞癌に対するナノ粒子を用いたがん細胞特異的解糖系阻害剤と腫瘍免疫応答効率化に関する検討2021
- Author(s)
  仁科惣治、日野啓輔
- Organizer
  第44回日本肝臓学会西部会
- Data Source
  KAKENHI-PROJECT-19H03644
[Presentation] 新規抗腫瘍免疫活性化作用を標的としたがん特異的解糖系阻害剤による肝がん治療応用2021
- Author(s)
  仁科惣治、日野啓輔
- Organizer
  第57回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19H03644
[Presentation] 肝細胞癌に対するナノ粒子を用いたがん細胞特異的解糖系阻害と腫瘍免疫応答効率化に関する検討2021
- Author(s)
  仁科惣治、日野啓輔
- Organizer
  第44回日本肝臓学会西部会
- Data Source
  KAKENHI-PROJECT-21K07925
[Presentation] 新規抗腫瘍免疫活性化作用を標的としたがん特異的解糖系阻害剤による肝がん治療応用2021
- Author(s)
  仁科惣治、日野啓輔
- Organizer
  第57回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-21K07925
[Presentation] 肝細胞癌の糖代謝抑制による腫瘍免疫賦活化と治療展開2020
- Author(s)
  仁科惣治、佐々木恭、日野啓輔
- Organizer
  第106回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-18K07923
[Presentation] 2-deoxy-D-glucose encapsulated PLGA nanoparticles suppress hepatocellular carcinoma through cytotoxic effect and activation of antitumor immunity2020
- Author(s)
  Sohji Nishina, Kyo Sasaki, Akira Yamauchi, Kotaro Fukuda, Keisuke Hino
- Organizer
  American Association for the Study of Liver Diseases (AASLD)-The Liver Meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07923
[Presentation] がん特異的解糖系阻害剤による肝細胞癌治療応用と免疫賦活化機構の解明2020
- Author(s)
  仁科惣治、佐々木　恭、日野啓輔
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19H03644
[Presentation] がん特異的解糖系阻害剤による肝細胞癌治療応用と腫瘍免疫活性化機構の解明2020
- Author(s)
  仁科惣治、佐々木恭、日野啓輔
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18K07923
[Presentation] 肝癌細胞の糖代謝抑制によるがん微小環境での腫瘍免疫賦活作用とその臨床応用2019
- Author(s)
  佐々木恭、仁科惣治、日野啓輔
- Organizer
  日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18K07923
[Presentation] Specific inhibition of cancer cell glycolysis enhances antitumor immunity in hepatocellular carcinoma2019
- Author(s)
  佐々木恭、仁科惣治、山内明、原裕一、福田宏太郎、日野啓輔
- Organizer
  APASL Single Topic Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07923
[Presentation] NAFLD進展・発癌抑制のためのミトコンドリア品質管理とその分子機構2019
- Author(s)
  原裕一, 田中敦, 佐々木恭, 仁科惣治, 日野啓輔
- Organizer
  第15回酸化ストレスと肝研究会
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] Immuno oncologyからみた肝細胞癌に対する2-deoxyD-glucose封入PLGAナノ粒子の抗腫傷効果2019
- Author(s)
  佐々木恭、仁科惣治、日野啓輔
- Organizer
  日本消化器病学会
- Data Source
  KAKENHI-PROJECT-18K07923
[Presentation] Anti tumor effects of 20deoxy-D-glucose encapsulated PLGA nanoparticles against hepatocellular carcinoma in term of tumor immunity2019
- Author(s)
  Sasaki K, Nishina S, Yamauchi A, Hara Y, Fukuda K, Hino K
- Organizer
  Annual Meeting of the American Association for the Study of Liver Diseases
- Data Source
  KAKENHI-PROJECT-19H03644
[Presentation] Treatment of hepatocellular carcinoma using 2-Antitumor effects of 2-deoxy-D-glucose encapsulated PLGA nanoparticles against hepatocellular carcinoma in terms of tumor immunity2019
- Author(s)
  佐々木恭、仁科惣治、山内明、原裕一、福田宏太郎、日野啓輔
- Organizer
  American Association for the Study of Liver Diseases(AASLD) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07923
[Presentation] Mitophagy誘導機構の解明2018
- Author(s)
  原裕一, 佐々木恭, 仁科惣治, 日野啓輔
- Organizer
  第14回酸化ストレスと肝研究会
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] 肝糖代謝阻害薬2-deoxy-D-glucose封入PLGAナノ粒子を用いた肝細胞癌治療開発2018
- Author(s)
  佐々木恭、仁科惣治、日野啓輔ら
- Organizer
  Japan Digestive Disease Week 2018 (JDDW 2018)
- Data Source
  KAKENHI-PROJECT-18K07923
[Presentation] Treatment of hepatocellular carcinoma using 2-deoxy-D-glucose encapsulated in PLGA nanoparticles in mice2018
- Author(s)
  佐々木恭、仁科惣治、日野啓輔ら
- Organizer
  American Association for the Study of Liver Diseases(AASLD) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07923
[Presentation] NAFLD 進展・発癌抑制のためのミトコンドリア品質管理とその分子機構2018
- Author(s)
  原裕一, 田中敦, 佐々木恭,仁科惣治, 日野啓輔
- Organizer
  肝類同壁細胞研究会構
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] 細胞内鉄欠乏によるミトコンドリア選択的オートファジーの分子機構2018
- Author(s)
  原裕一, 佐々木恭, 仁科惣治, 日野啓輔
- Organizer
  第42回日本鉄バイオサイエンス学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] 肝発癌抑制機構としてのmitophagy誘導2018
- Author(s)
  原　裕一、仁科惣治、日野啓輔
- Organizer
  第104回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] Treatment of hepatocellular carcinoma using 2-deoxy-D-glucose encapsulated in PLGA nanoparticles in mice2018
- Author(s)
  佐々木恭、仁科惣治、日野啓輔ら
- Organizer
  APASL Single Topic Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07923
[Presentation] ミトコンドリア内鉄欠乏によるmitophagy 誘導機構2018
- Author(s)
  原　裕一, 仁科惣治, 日野啓輔
- Organizer
  第42回日本肝臓学会西部会
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] ミトコンドリア内鉄欠乏によるmitophagy誘導機構2017
- Author(s)
  原裕一, 佐々木恭, 仁科惣治, 日野啓輔a, Keisuke Hino
- Organizer
  AASLD2015(American Association for the Study of Liver Diseases2015)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] Mitophagy誘導機構の解明2017
- Author(s)
  原裕一, 簗取いずみ, 日野啓輔
- Organizer
  JDDW2017 肝臓学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] ミトコンドリア内鉄欠乏によるmitophagy誘導機構2017
- Author(s)
  原　裕一、仁科惣治、日野啓輔
- Organizer
  第42回日本肝臓学会西部会
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] Loss of iron triggers mitophagy by inducing mitochondrial ferritin2017
- Author(s)
  Yuichi Hara, Kyo Sasaki, Soji Nishina, Keisuke Hino
- Organizer
  AASLD2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] LOSS OF IRON UPREGULATES MITOCHONDRIA FERRITIN AND TRIGGERS MITOPHAGY THROUGH THE BINDING OF MITOCHONDRIA FERRITIN TO NUCLEAR RECEPTOR COACTIVATOR 42017
- Author(s)
  Yuichi Hara, Izumi Yanatori, Kyo Sasaki, Sohji Nishina, Fumio Kishi, Keisuke Hino
- Organizer
  Seventh Congress of the International BioIron Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] NASH肝発癌抑制機構としてのmitophagy誘導2017
- Author(s)
  原裕一,仁科惣治, 日野啓輔
- Organizer
  第53回日本肝臓学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] Los of iron up regulates mitochondria ferritin and triggers mitophagy2017
- Author(s)
  Hara Y, Sasaki K, Nishina S, Hino K
- Organizer
  The Annual Meeting of American Association for the Study of Liver Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] NASH肝発癌抑制機構としてのmitophagy誘導2017
- Author(s)
  原　裕一、仁科惣治、日野啓輔
- Organizer
  第53回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] 鉄キレートはC型肝炎ウイルスによるmitophagyの抑制を回復させる2016
- Author(s)
  原裕―, 仁科惣治, 日野啓輔
- Organizer
  第52回日本肝臓学会総会
- Place of Presentation
  千葉幕張メッセ
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] 鉄キレートはC型肝炎ウイルスによるmitophagyの抑制を回復させる2016
- Author(s)
  原裕―, 仁科惣治, 日野啓輔
- Organizer
  第52回日本肝臓学会総会
- Place of Presentation
  幕張メッセ　千葉
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] 肝細胞癌進展抑制におけるDPP4阻害薬の分子学的機序2016
- Author(s)
  仁科惣治, 山内明, 富山恭行, 吉岡奈穂子, 原裕一, 日野啓輔
- Organizer
  JDDW2016
- Place of Presentation
  神戸ポートピアホテル
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] Comparison of therapeutic effect of sorafenib and drug eluting beads transcatheter arterial chemoembolization on hepatocellular carcinoma refractory to conventional transcatheter arterial chemoembolization2016
- Author(s)
  Yasuyuki Tomiyama, Naoko Yoshioka, Nobuko Koyama, Kyo Sasaki, Sohji Nishina, Yuichi Hara, Keisuke Hino
- Organizer
  the 12th JSH Single Topic Conference in Kanazawa
- Place of Presentation
  HOTEl nikko Kanazawa　Ｊａｐａｎ
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] NASH肝発癌抑制機構としてのmitophagy誘導2016
- Author(s)
  原裕一, 仁科惣治, 日野啓輔
- Organizer
  第102回日本消化器病学会総会
- Place of Presentation
  東京京王プラザホテル
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] 肝細胞癌治療標的としてのCD26(DPP4) の意義2016
- Author(s)
  仁科惣治, 山内明, 小山展子, 富山恭行, 吉岡奈穂子, 原裕一, 日野啓輔
- Organizer
  第113回日本内科学会総会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] 鉄キレートはC型肝炎ウイルスによるmitophagyの抑制を回復させる2016
- Author(s)
  原裕一, 仁科惣治, 日野啓輔
- Organizer
  第102回日本消化器病学会総会
- Place of Presentation
  京王プラザホテル　東京
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] Iron chelator suppresses hepatocarcinogenesis through mitophagy induction in STAM mice2016
- Author(s)
  Yuichi Hara, Kyo Sasaki, Soji Nishina, Keisuke Hino
- Organizer
  AASLD LiverLearning 2016
- Place of Presentation
  Boston,USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] Dipeptidyl peptidase 4 (DPP4) inhibitor enhances natural killer cell chemotaxis, improving tumor immunity against hepatocellular carcinoma2016
- Author(s)
  Sohji Nishina, Akira Yamauchi, Yuichi Hara, Kyo Sasaki, Keisuke Hino
- Organizer
  Annual Meeting of AASLD
- Place of Presentation
  Boston（米国）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] Iron chelator suppresses hepatocarcinogenesis through mitophagy induction in STAM mice2016
- Author(s)
  Yuichi Hara, Kyo Sasaki, Soji Nishina, Keisuke Hino
- Organizer
  Annual Meeting of AASLD
- Place of Presentation
  Boston（米国）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] Dipeptidyl peptidase 4 (DPP4) inhibitor enhances natural killer cell chemotaxis, improving tumor immunity against hepatocellular carcinoma2016
- Author(s)
  Sohji Nishina, Akira Yamauchi, Yuichi Hara, Kyo Sasaki, Keisuke Hino
- Organizer
  AASLD LiverLearning 2016
- Place of Presentation
  Boston,USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09384
[Presentation] Iron chelation restores mitophagy suppressed by hepatitis C virus2015
- Author(s)
  Hara Y, Nishina S, Hirayama T, Nagasawa H, Hino K
- Organizer
  Annual Meeting of American Association for the Study of Liver Diseases 2015
- Place of Presentation
  San Francisco
- Year and Date
  2015-11-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] DPP-4 inhibitor, anagliptin suppresses the progression of Hepatocellular carcinoma2015
- Author(s)
  Nishina S, Yamauchi A, Tomiyama Y, Hara Y, Hino K
- Organizer
  Annual Meeting of American Association for the Study of Liver Diseases 2015
- Place of Presentation
  San Francisco
- Year and Date
  2015-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] Hepatitis C virus core protein suppresses mitophagy by interacting with Parkin in the context of mitochondrial depolarization2014
- Author(s)
  Hara Y, Yanatori I, Ikeda M, Kiyokage E, Nishina S, Tomiyama Y, Toida K, Kishi F, Kato N, Imamura M, Chayama K, Hino K
- Organizer
  5th World Congress on Targeting Mitochondria
- Place of Presentation
  Ritz Carlton Hotel, Berlin, Germany
- Year and Date
  2014-10-30
- Data Source
  KAKENHI-PROJECT-25670374
[Presentation] Oral glucose tolerance test predicts hepatic fibrosis in nonalcoholic fatty liver disease patients without overt diabetes mellitus.2014
- Author(s)
  Nishina S, Hyogo H, Kawanaka M, Miyake T, Abe M, Yamashita S, Tobita H, Sato S, Hiasa Y, Chayama K, Hino K
- Organizer
  The 65th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Hynes Convention Center, Boston, USA
- Year and Date
  2014-11-09
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] HCVとミトコンドリアのバイオジェネーシスとの関連性2014
- Author(s)
  原裕一, 仁科惣治, 日野啓輔
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2014-05-30
- Data Source
  KAKENHI-PROJECT-24659377
[Presentation] HCVとミトコンドリアのバイオジェネーシスとの関連性2014
- Author(s)
  原裕一, 仁科惣治, 日野啓輔
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  ホテルニューオータニ、東京
- Year and Date
  2014-05-30
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] HCV とミトコンドリアバイオジェネシスとの関連性2014
- Author(s)
  原裕一, 仁科惣治, 日野啓輔
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2014-05-30
- Data Source
  KAKENHI-PROJECT-23390201
[Presentation] Hepatitis C virus core protein suppresses mitophagy by interacting with Parkin in the context of mitochondrial depolarization2014
- Author(s)
  Hara Y, Yanatori I, Ikeda M, Kiyokage E, Nishina S, Tomiyama Y, Toida K, Kishi F, Kato N, Imamura M, Chayama K, Hino K
- Organizer
  5th World Congress on Targeting Mitochondria
- Place of Presentation
  Ritz Carlton Hotel, Berlin, Germany
- Year and Date
  2014-10-30
- Data Source
  KAKENHI-PROJECT-26293179
[Presentation] HCVとミトコンドリアのバイオジェネーシスとの関連性2014
- Author(s)
  原裕一, 仁科惣治, 日野啓輔
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  ホテルニューオータニ、東京
- Year and Date
  2014-05-30
- Data Source
  KAKENHI-PROJECT-25670374
[Presentation] Hepatitis C virus core protein suppresses mitophagy by interacting with Parkin2013
- Author(s)
  Hara Y, Nishina S, Hino K, et al
- Organizer
  The 64th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Washington DC
- Year and Date
  2013-11-02
- Data Source
  KAKENHI-PROJECT-23390201
[Presentation] Suppressed mitophagy in transgenic mice expressing hepatitis C virus polyprotein2013
- Author(s)
  Yuichi Hara, Izumi Yanatori , Emi Kiyokage , Sohji Nishina, Yasuyuki Tomiyama, Kazunori Toida , Masanori Ikeda , Fumio Kishi , Nobuyuki Kato , Michio Imamura , Kazuaki Chayama , Keisuke Hino
- Organizer
  The 2nd JSGE International Topic Conference
- Place of Presentation
  Kagosima castle park hotel,Kagoshima, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-24659377
[Presentation] Hepatitis C virus core protein suppresses mitophagy2013
- Author(s)
  Yuichi Hara, Izumi Yanatori , Emi Kiyokage , Sohji Nishina, Yasuyuki Tomiyama, Kazunori Toida , Masanori Ikeda , Fumio Kishi , Nobuyuki Kato , Michio Imamura , Kazuaki Chayama , Keisuke Hino
- Organizer
  AASLD
- Place of Presentation
  Walter E. Washington Convention Center, Washington, USA
- Invited
- Data Source
  KAKENHI-PROJECT-24659377
[Presentation] Ovariectomized transgenic mice expressing hepatitis C virus poltprotein develop hepatic steatosis through suppression of AMPK/PGCα signaling2013
- Author(s)
  Tomiyama Y, Nishina S, Hara Y, Hino K
- Organizer
  The 64th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Washington DC
- Year and Date
  2013-11-02
- Data Source
  KAKENHI-PROJECT-23390201
[Presentation] Supressed Mitophagy in Transgenic mice Expressing Hepatitis C Virus Polyprotein2013
- Author(s)
  Yuichi Hara, Izumi Yanatori , Emi Kiyokage , Sohji Nishina, Yasuyuki Tomiyama, Kazunori Toida , Masanori Ikeda , Fumio Kishi , Nobuyuki Kato , Michio Imamura , Kazuaki Chayama , Keisuke Hino
- Organizer
  Cell Symposia : Mitochondria
- Place of Presentation
  Rua Latino Coelho, 1Lisbon,Portugal
- Invited
- Data Source
  KAKENHI-PROJECT-24659377
[Presentation] The hepatitis C virus core protein suppresses mitophagy by interacting with Parkin2013
- Author(s)
  Hara Y, Nishina S, Hino K, et al
- Organizer
  Cell symposium Mitochondria : from signaling to disease
- Place of Presentation
  Lisbon
- Year and Date
  2013-05-05
- Data Source
  KAKENHI-PROJECT-23390201
[Presentation] HCVコア蛋白とParkinとの相互作用よるmitophagyの抑制及びHCV増殖に対する影響2013
- Author(s)
  原　裕一　仁科惣治　日野啓輔
- Organizer
  日本肝臓学会西部会
- Place of Presentation
  長良川国際会議場・岐阜都ホテル,岐阜、日本
- Invited
- Data Source
  KAKENHI-PROJECT-24659377
[Presentation] Supplementation with branched-chain amino acids improves HCV-induced iron metabolic disorder via upregulation of antioxidant potential by restoring mitochondrial complex I function in iron overloaded transgenic mice expressing HCV polyprotein2012
- Author(s)
  Korenaga M, Nishina S, Korenaga K, Tomiyama Y, Hara Y, Sakai Y, Shimonaka Y, Mizokami M, Hino K
- Organizer
  The 63rd annual meeting of the American association for the study of liver diseases (AASLD)
- Place of Presentation
  Boston, U.S.
- Data Source
  KAKENHI-PROJECT-22590750
[Presentation] IFN 少量長期投与はHCV 関連肝発癌における鉄代謝異常を改善するワークショップ10 肝細胞癌の発症と再発予防を目指した慢性肝炎の治療2012
- Author(s)
  是永匡紹、仁科惣治、是永圭子、日野啓輔
- Organizer
  第48回日本肝臓総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-22590750
[Presentation] Anti-interferon-α neutralizing antibodies interact with viral responses to interferon in patients with hepatitis C virus infection bearing interferon sensitive IL28B single nucleotide polymorphisms.2012
- Author(s)
  Korenaga M, Korenaga K, Nishina S, Yoshioka N, Tomiyama Y, Hara Y, Sugiyama M, Nishida N, Murata K, Masaki N, Mizokami M, Hino K.
- Organizer
  The 63rd annual meeting of the American association for the study of liver diseases (AASLD)
- Place of Presentation
  Boston, U.S.
- Data Source
  KAKENHI-PROJECT-22590750
[Presentation] 鉄負荷HCVTgMにおけるhepcidin25発現とサイトカインの網羅的解析2011
- Author(s)
  是永匡紹, 田中志保, 佐々木雄亮, 下中靖, 日野啓輔
- Organizer
  第97回日本消化器病学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590750
[Presentation] BCAA顆粒はHCVTgMにおける肝内鉄過剰と酸化ストレスを抑制する2011
- Author(s)
  是永匡紹, 仁科惣治, 田中志保, 是永圭子, 日野啓輔
- Organizer
  第47回日本肝臓学会総会ワークショップ1「代謝・酸化ストレスの場としての肝臓」
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590750
[Presentation] Dietary supplementation with branched-chain amino acids reduces hepatic iron accumulation induced by hepatitis C virus proteins and iron overload in mice.2011
- Author(s)
  Korenaga M, Korenaga K, Nishina S, Tomiyama Y, Hino K
- Organizer
  The 62rd annual meeting of the American association for the study of liver diseases (AASLD)
- Place of Presentation
  San Francisco, U.S.
- Data Source
  KAKENHI-PROJECT-22590750
[Presentation] テーラーメード医療時代のおける抗IFNα抗体測定の意義2011
- Author(s)
  是永匡紹是永圭子日野啓輔
- Organizer
  第39回日本肝臓学会西部会シンポジウム1テーラーメード医療時代のC型肝炎治療戦略
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-22590750
[Presentation] Oral branched-chain amino acid supplementation reduces oxidative stress and interacts with iron metabolism in patients with hepatitis C virus-related advanced liver fibrosis -a pilot study-.2011
- Author(s)
  Korenaga M, Korenaga K, Nishina S, Tomiyama Y, Hino K
- Organizer
  The 62rd annual meeting of the American association for the study of liver diseases (AASLD)
- Place of Presentation
  San Francisco, U.S.
- Data Source
  KAKENHI-PROJECT-22590750
[Presentation] C型慢性肝疾患の鉄代謝異常に対するBCAA顆粒投与の有効性2011
- Author(s)
  是永匡紹是永圭子日野啓輔
- Organizer
  第15回日本肝臓学会大会第53回日本消化器病学会大会シンポジウム14 代謝性・遺伝性肝疾患研究の進歩
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22590750
[Presentation] Iron induced oxidative stress inhibits viral replication in full genomic hepatitis C virus replicon cells.2010
- Author(s)
  Korenaga M, Hino K, et al
- Organizer
  The 61^<th> Annual Meeting of the American Association for the Study of Liver Disease
- Place of Presentation
  Boston, USA
- Year and Date
  2010-11-04
- Data Source
  KAKENHI-PROJECT-20590782
[Presentation] 肝内鉄過剰とミトコンドリア障害が誘導する酸化ストレスはC型肝炎ウイルス(HCV)増殖を抑制する2010
- Author(s)
  是永匡紹, 池田正徳, 日野啓輔
- Organizer
  第14回日本肝臓学会大会第52回日本消化器病学会大会パネルディスカッション7 代謝異常(金属代謝を含む)からみたC型肝炎の病態解析
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590750
[Presentation] Glycyrrhizin reduces hepatic steatosis induced b6y hepatitis C virus protein and iron overload in mice.2010
- Author(s)
  Korenaga M, Hino K, et al
- Organizer
  The 61^<th> Annual Meeting of the American Association for the Study of Liver Disease
- Place of Presentation
  Boston, USA
- Year and Date
  2010-11-04
- Data Source
  KAKENHI-PROJECT-20590782
[Presentation] Inhibition of the oxidative stress reduces hepatic iron overload through the upregulation of hepcidin level in transgenic mice expressing the hepatitis Cvirus polyprotein2009
- Author(s)
  Korenaga M, Nishina S, Hino K, et al.
- Organizer
  The 60^<th> Annual Meeting of the American Association for the Study of Liver Disease
- Place of Presentation
  Boston, USA
- Year and Date
  2009-11-03
- Data Source
  KAKENHI-PROJECT-20590782
[Presentation] Inhibition of the oxidative stress reduces hepatic iron overload through the upregulation of hepcidin level in transgenic mice expressing the hepatitis C virus polyprotein.2009
- Author(s)
  Korenaga M, Nishina S, Hino K, et al
- Organizer
  The 60^<th> Annual Meeting of the American Association for the Study of Liver Disease
- Place of Presentation
  Boston, USA
- Year and Date
  2009-11-03
- Data Source
  KAKENHI-PROJECT-20590782
[Presentation] Iron overload causes hepatic steatosis through the endopasmic reticulum stress in transgenic mice expressing the hepatitis C virus polyprotein.2008
- Author(s)
  Nishina S, Hino K, Korenaga M, et al
- Organizer
  The 59^<th> Annual Meeting of the American Association for the Study of Liver Disease
- Place of Presentation
  Boston, USA
- Year and Date
  2008-11-02
- Data Source
  KAKENHI-PROJECT-20590782
[Presentation] Hepatitis C virus-induced reactive oxygen species cause hepatic iron accumulation by reducing hepcidin transcription2007
- Author(s)
  Hino, K, et. al.
- Organizer
  14th International Symposium on Hepatitis C virus and Related Viruses
- Place of Presentation
  Glasgow
- Year and Date
  2007-09-09
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590736
[Presentation] Hepatitis C virus-induced reactive oxygen species cause hepatic iron accu mulation by reducing hepcidin transcription2007
- Author(s)
  Hino K, et. al.
- Organizer
  14th International Symposium on Hepatitis C virus and Related Viruses
- Place of Presentation
  Glasgow, UK
- Year and Date
  2007-09-09
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590736
[Presentation] Splenectomy causes hepatic inflammation and oxidative stress through activation of Kupffer cells in iron-overloaded mice
- Author(s)
  Sohji Nishina, Yuichi Hara, Yasuyuki Tomiyama, Keisuke Hino
- Organizer
  The 64th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  WALTER E. Washington Convention Center Washington,DC.USA
- Data Source
  KAKENHI-PROJECT-23390201
[Presentation] Ovariectomized transgenic mice expressing hepatitis C virus polyprotein develop hepatic steatosis through suppression of AMPK/PGC1a signaling
- Author(s)
  Yasuyuki Tomiyama, Sohji Nishina , Yuichi Hara, Keisuke Hino
- Organizer
  The 64th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Waltere Washington Convention Center, Washington DC, USA
- Data Source
  KAKENHI-PROJECT-25670374
[Presentation] HCVコア蛋白とParkinとの相互作用によるマイトファジーの抑制
- Author(s)
  原裕一，仁科惣治，日野啓輔
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  京王プラザホテル、東京
- Data Source
  KAKENHI-PROJECT-23390201
[Presentation] Splenectomy causes hepatic inflammation and oxidative stress through activation of Kupffer cells in iron-overloaded mice
- Author(s)
  Sohji Nishina, Yuichi Hara, Yasuyuki Tomiyama, Keisuke Hino
- Organizer
  17th International Symposium on Cells of the Hepatic Sinusoid
- Place of Presentation
  Osaka International Convention Center, Osaka, Japan
- Data Source
  KAKENHI-PROJECT-23390201
[Presentation] The hepatitis C virus core protein suppresses mitophagy by affecting Parkin
- Author(s)
  Yuichi Hara, Izumi Yanatori , Masanori Ikeda, Sohji Nishina, Yasuyuki Tomiyama, Fumio Kishi, Kazunori Toida, Nobuyuki Kato, Kazuaki Chayama , Keisuke Hino
- Organizer
  Cell Sumposium Mitochondria:from Signaling to Disease
- Place of Presentation
  Sheraton Lisbosa, Lisbon, Portugal
- Data Source
  KAKENHI-PROJECT-25670374
[Presentation] HCVタンパクはエストロゲン欠乏起因性酸化ストレスに対する抗酸化機構を抑制する
- Author(s)
  富山恭行，小山展子，佐々木恭，仁科惣治，吉岡奈穂子，原　裕一，日野啓輔
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  京王プラザホテル、東京
- Data Source
  KAKENHI-PROJECT-23390201
[Presentation] Fibroblast Activation Protein (FAP) Expression of Cancer-Associated Fibroblast Predicts Poor Prognosis in Patients With Pancreatic Adenocarcinoma
- Author(s)
  Tomoya Kawase, Koji Yoshida, Keisuke Hino
- Organizer
  DDW2013(American Gastroenterological Association)
- Place of Presentation
  orange Country Convention Center, Orland FL, USA
- Data Source
  KAKENHI-PROJECT-25670374
[Presentation] Ovariectomized transgenic mice expressing hepatitis C virus polyprotein develop hepatic steatosis through suppression of AMPK/PGC1a signaling
- Author(s)
  Yasuyuki Tomiyama, Sohji Nishina , Yuichi Hara, Keisuke Hino
- Organizer
  The 64th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  WALTER E. Washington Convention Center Washington,DC.US
- Data Source
  KAKENHI-PROJECT-23390201
[Presentation] The hepatitis C virus core protein suppresses mitophagy by affecting Parkin
- Author(s)
  Yuichi Hara, Izumi Yanatori , Masanori Ikeda, Sohji Nishina, Yasuyuki Tomiyama, Fumio Kishi, Kazunori Toida, Nobuyuki Kato, Kazuaki Chayama , Keisuke Hino
- Organizer
  Cell Symposium Mitochondria:from Signaling to Disease
- Place of Presentation
  Sheraton Lisboa, Lisbon, Portugal
- Data Source
  KAKENHI-PROJECT-23390201
[Presentation] HCVコア蛋白とParkinとの相互作用によるマイトファジーの抑制
- Author(s)
  原裕一，仁科惣治，日野啓輔
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  京王プラザホテル、東京
- Data Source
  KAKENHI-PROJECT-25670374
[Presentation] Splenectomy causes hepatic inflammation and oxidative stress through activation of Kupffer cells in iron-overloaded mice
- Author(s)
  Sohji Nishina, Yuichi Hara, Yasuyuki Tomiyama, Keisuke Hino
- Organizer
  17th International Symposium on Cells of the Hepatic Sinusoid
- Place of Presentation
  Osaka International Convention Center, osaka, Japan
- Data Source
  KAKENHI-PROJECT-25670374
[Presentation] Fibroblast Activation Protein (FAP) Expression of Cancer-Associated Fibroblast Predicts Poor Prognosis in Patients With Pancreatic Adenocarcinoma
- Author(s)
  Tomoya Kawase, Koji Yoshida, Keisuke Hino
- Organizer
  DDW2013(American Gastroenterological Association)
- Place of Presentation
  Orange Country Convention Center, Orlando FL, USA
- Data Source
  KAKENHI-PROJECT-23390201
[Presentation] Hepatitis C virus core protein suppresses mitophagy by interacting with Parkin
- Author(s)
  Yuhichi Hara, Izumi Yanatori, EmiKiyokage, Sohji Nishina, Yasuyuki Tomiyama, Kazunori Toida, Masanori Ikeda, Fumio Kishi, Nobuyuki Kato, Keisuke Hino
- Organizer
  The 64th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Waltere Washington Convention Center, Washington DC, USA
- Data Source
  KAKENHI-PROJECT-25670374
[Presentation] Hepatitis C virus core protein suppresses mitophagy by interacting with Parkin
- Author(s)
  Yuhichi Hara, Izumi Yanatori, EmiKiyokage, Sohji Nishina, Yasuyuki Tomiyama, Kazunori Toida, Masanori Ikeda, Fumio Kishi, Nobuyuki Kato, Keisuke Hino
- Organizer
  The 64th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  WALTER E. Washington Convention Center Washington,DC.US
- Data Source
  KAKENHI-PROJECT-23390201
[Presentation] Splenectomy causes hepatic inflammation and oxidative stress through activation of Kupffer cells in iron-overloaded mice
- Author(s)
  Sohji Nishina, Yuichi Hara, Yasuyuki Tomiyama, Keisuke Hino
- Organizer
  The 64th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Waltere Washington Convention Center, Washington DC, USA
- Data Source
  KAKENHI-PROJECT-25670374
[Presentation] HCVタンパクはエストロゲン欠乏起因性酸化ストレスに対する抗酸化機構を抑制する
- Author(s)
  富山恭行，小山展子，佐々木恭，仁科惣治，吉岡奈穂子，原　裕一，日野啓輔
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  京王プラザホテル、東京
- Data Source
  KAKENHI-PROJECT-25670374

1. NISHINA Sohji (70550961)

# of Collaborated Projects: 8 results

# of Collaborated Products: 102 results
2. HARA Yuichi (60550952)

# of Collaborated Projects: 7 results

# of Collaborated Products: 89 results
3. KORENAGA Masaaki (70420536)

# of Collaborated Projects: 5 results

# of Collaborated Products: 38 results
4. KORENAGA Keiko (60420535)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
5. IKEDA Masanori (30315767)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. KISHI Fumio (40153077)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
7. GONDO Toshikazu (30221253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. KIMURA Teruaki (40346557)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 山内明 (80372431)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. KAZUMOTO Murata

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. NISHIDA Nao

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. Sugiyama Masaya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. IKUTA Katsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. YAMAMURA Masahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. ASAHINA Yasuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. YANATORI Izumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 阿部雅則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 土岐康通

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 酒井愛子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 草永真志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 山本健

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
22. 徳永勝士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 赤澤宏平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 澤本和延

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 坂本直哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hino Keisuke 日野 啓輔

HINO Keisuke 日野 啓輔

Research Projects

Research Products

Co-Researchers

The study for liver cancer specific glycolysis inhibition and efficiency of cancer immunity using novel drug delivery system

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Elucidation of the mechanism of hepatocarcinogenesis suppression by mitochondrial ferritin

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Activation of tumor immunity by metabolic reprogramming in liver cancer microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Development of an anticancer therapy against liver cancer using 2-deoxy-D-glucose encapsulated in polymer poly (lactic-co-glycolic acid) nanoparticles

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Iron loss-induced mitophagy via mitochondria ferritin suppresses NASH-related hepatocellular carcinoma

Principal Investigator

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Research Field

Research Institution

Investigation of hepatocarcinogenic mechanisms by comprehensive ahalysis of cellular signaling responding to oxidative stressPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Restoration of mitophagy as a strategy for inhibiting hepatocarcinogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Hepatitis C virus core protein suppresses mitophagy by interacting with parkin in the context of mitochondrial depolarization.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of hepatocarcinogenesis based on gender and mitochondrial biogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Association of between HCV induced mitochondria dysfunction and viral response by interferon in hepatic iron overloaded

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Crosstalk between iron metabolic disorder and lipid metabolic disorder in hepatocarcinogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of hepatic mitochondrial function in carcinogenesis of chronic hepatitis C

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Iron metabolic disorder and hepatocarcinogenesis in hepatitis CPrincipal Investigator

Principal Investigator

Project Period (FY)

Hino Keisuke 日野啓輔

HINO Keisuke 日野啓輔

[Book] HEPATOLOGY　PRACTICE（第３巻）2014

[Book] HEPATOLOGY　PRACTICE（第３巻）2014

[Book] 診断と治療　ウイルス肝炎の新展開2013

[Book] 診断と治療　ウイルス肝炎の新展開2013