MATSUNAGA Yoichi 松永洋一

Researcher Number	80239053
Affiliation (based on the past Project Information) *help	2005 – 2022: 徳島文理大学, 薬学部, 教授 2007: Tokushima Bunri University, Pyarmacology, Professor 2004: 福岡大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Laboratory medicine / Neurology Except Principal Investigator Circulatory organs internal medicine / Basic Section 59040:Nutrition science and health science-related / Sports science / Cardiovascular medicine
Keywords	Principal Investigator アルツハイマー病 / 蛋白凝集 / アミロイドベータ / ブレーカーペプチド / アミロイドベータ蛋白 / ベータアミロイド / 蛋白立体構造変化 / 蛋白２次構造変化 / ビタミンＤ / ベータアミロイド蛋白 … More / ビタミンD活性体 / ビタミンD前駆体 / アルツハイマー病進行段階 / 早期アルツハイマー病 / ビタミンD / 血液検査診断 / アミロイドβ / βアミロイド蛋白凝集 / アルツハイマー病期診断 / 早期アルツハイマー病診断 / ２５（OH)VD3濃度 / １，２５（OH)２VD3濃度 / 血清ビタミンD濃度 / βアミロイド蛋白 / moltenglobule / stefin B / breaker peptides / splenocytes / dendritic cells / neurotoxicity / Amyloid-beta / prion / ホーミング / 神経細胞毒性 / 毒性阻止ペプチド / プリオン / モルテングロビュール / ステファンB / 脾臓 / 樹状突起細胞 / 神経細胞毒 / プリオンン / アミロイドベータ蛋白特異抗体 / 蛋白加温修飾 / アルツハイマー病患者血清 / アルツハイマー病診断 / 脳内蛋白異常凝集 / ベータシート形成 / プリオン蛋白 / ビタミンＤ３ / ビタミンＤ２ / オリゴマー形成 / ベータシート構造 / 蛋白質加温凝集 / 血清診断法 / アミロイド蛋白凝集 / 温熱変化 / 患者血清 / 立体構造変化 / 診断法 / アミロイド蛋白凝集抑制 / 血清アミロイド蛋白濃度 / 記憶障害 / ブレーカーペプタイド / 血清診断 / 加温 / アミロイド蛋白 … More Except Principal Investigator リポ蛋白 / 人工HDL / 動脈硬化 / 臨床 / アポリポ蛋白 / 高比重リポ蛋白 / 脂質 / 診断 / 予防・治療 / 凝集性蛋白質 / ビタミン類 / αーシヌクレイン / TDP-43 / α-シヌクレイン / プリオンタンパク質 / アミロイドβ / 活性型ビタミンD不活化酵素 / 25OHビタミンD水酸化酵素 / ビタミンD水酸化酵素 / 筋萎縮性側索硬化症 / 神経変性疾患 / ビタミンD代謝酵素 / ビタミンD / 脂溶性ビタミン / プリオン病 / 多系統萎縮症 / パーキンソン病 / アルツハイマー病 / 有酸素性運動 / 運動 / 耐糖能異常 / 乳酸域値 / 有酸素運動 / 骨格筋 / ミトコンドリア / HDL / 高比重リポタンパク / 遺伝子導入 / ペプチド / 虚血性心臓病 / 低比重リポ蛋白 / 膜輸送体 / コレステロール / 分子血管病態学 / 遺伝子 / 遺伝子多型 / 発現制御 / 循環器・高血圧 Less

Development of early diagnosis, prevention, and treatment for neurodegenerative diseases by vitamins
- Principal Investigator
  
  Suenaga Midori
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tokushima Bunri University
Beneficial effects of aerobic exercise on HDL metabolism and cellular mitochondria function by an improvement of HDL function.
- Principal Investigator
  
  UEHARA Yoshinari
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Sports science
- Research Institution
  Fukuoka University
Serum vitamin D concentration is a biomarker for early stage of Alzheimer's disease and control amyliod-beta aggregation.Principal Investigator
- Principal Investigator
  
  MATSUNAGA Yoichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Tokushima Bunri University
Development of a novel gene transferable HDL-generating peptide.
- Principal Investigator
  
  UEHARA YOSHINARI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Fukuoka University
Developments of diagnostics for Mild Cognitive Impairment by patients serum and inhibition of the disease progress with vitamin DPrincipal Investigator
- Principal Investigator
  
  MATSUNAGA Yoichi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Tokushima Bunri University
Establishment of a novel therapeutic strategyfor atherosclerosis via soluble lipid transporter.
- Principal Investigator
  
  UEHARA Yoshinari
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Fukuoka University
A new diagnostic approach of Alzheimer's Disease based on the conformational changes of Aβ in serumPrincipal Investigator
- Principal Investigator
  
  MATSUNAGA Yoichi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Tokushima Bunri University
A novel function of membrane cholesterol transporter and a therapeutic strategy for atherosclerosis
- Principal Investigator
  
  UEHARA Yoshinari
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Fukuoka University
A role of spleen in the conformational transition of prion proteinPrincipal Investigator
- Principal Investigator
  
  MATSUNAGA Yoichi
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tokushima Bunri University
  Fukuoka University

[Book] Vitamin D:Vitamin Daffects neuronal peptides in neurodegenerative sdisease; Differences of VD2 and VD3 for affinity to amyloid-beta and scrapie prion protein in vitro.2016
- Author(s)
  Matsunaga Y.
- Total Pages
  26
- Publisher
  INTECH
- Data Source
  KAKENHI-PROJECT-15K08631
[Book] Biological Functions and Clinical Implications; ApoA-I Mutations2010
- Author(s)
  A.Matsunaga, Y.Uehara, B.Zhang, K.Saku
- Publisher
  Academic Press (ELSEVIER)
- Data Source
  KAKENHI-PROJECT-22590832
[Journal Article] Role of cytochrome P450 for vitamin D metabolisms in patients with neurodegenerative disorders2022
- Author(s)
  Kakimoto Asako、Ogura Hiromu、Suenaga Midori、Mishima Takayasu、Fujioka Shinsuke、Ouma Shinji、Matsunaga Yoichi、Tsuboi Yoshio
- Journal Title
  
  Clinical Parkinsonism & Related Disorders
  
  Volume: 7 Pages: 100162-100162
- DOI
  10.1016/j.prdoa.2022.100162
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11009
[Journal Article] Circulatory 25(OH)D and 1,25(OH)2D as differential biomarkers between multiple system atrophy and Parkinson's disease patients2021
- Author(s)
  Ogura Hiromu、Hatip-Al-Khatib Izzettin、Suenaga Midori、Hatip Funda Bolukbasi、Mishima Takayasu、Fujioka Shinsuke、Ouma Shinji、Matsunaga Yoichi、Tsuboi Yoshio
- Journal Title
  
  eNeurologicalSci
  
  Volume: 25 Pages: 100369-100369
- DOI
  10.1016/j.ensci.2021.100369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11009
[Journal Article] A novel diagnostic marker for progressive supranuclear palsy targeting atrophy of the subthalamic nucleus2021
- Author(s)
  Fujioka Shinsuke、Morishita Takashi、Takano Koichi、Takahashi Nobutaka、Kurihara Kanako、Nishida Akihiro、Mishima Takayasu、Suenaga Midori、Matsunaga Yoichi、Tsuboi Yoshi
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 423 Pages: 117366-117366
- DOI
  10.1016/j.jns.2021.117366
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11009
[Journal Article] Table tennis for patients with Parkinson’s disease: A single-center, prospective pilot study2021
- Author(s)
  Inoue Kenichi、Fujioka Shinsuke、Nagaki Koichi、Suenaga Midori、Kimura Kazuki、Yonekura Yukiko、Yamaguchi Yoshiki、Kitano Kosuke、Imamura Ritsuko、Uehara Yoshinari、Kikuchi Hitoshi、Matsunaga Yoichi、Tsuboi Yoshio
- Journal Title
  
  Clinical Parkinsonism & Related Disorders
  
  Volume: 4 Pages: 100086-100086
- DOI
  10.1016/j.prdoa.2020.100086
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11009
[Journal Article] Serine Protease Inhibitors and Activators From Dalbergia Tonkinensis Species2020
- Author(s)
  Son N, Suenaga M, Matsunaga Y, Chinh L, Kubo M, Harada K, Cuong N, Fukuyama Y
- Journal Title
  
  J Nat Med
  
  Volume: 74 Issue: 1 Pages: 257-263
- DOI
  10.1007/s11418-019-01347-y
- NAID
  40022130337
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11009, KAKENHI-PROJECT-20K05736, KAKENHI-PROJECT-16K01921
[Journal Article] Seruum vitamin D in patients with mild cognitive ipairment and Alzheimer's disease.2018
- Author(s)
  Ouma S, Suenaga M, Hatip FF,Hatip IZ, Tsuboi S, Matsunaga Y.
- Journal Title
  
  Brain and Behavior
  
  Volume: 8 Issue: 3 Pages: 1-12
- DOI
  10.1002/brb3.936
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08631
[Journal Article] Novel neurotrophic phenylbutenoids from Indonesian ginger Bangle, Zingiber purpureum.2015
- Author(s)
  M. Kubo, M. Gima, K. Baba, M. Nakai, K. Harada, M. Suenaga, Y. Matsunaga, E. Kato, S. Hosoda, Y. Fukuyama.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 25 Issue: 7 Pages: 1586-1591
- DOI
  10.1016/j.bmcl.2015.02.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08012, KAKENHI-PROJECT-15K08631, KAKENHI-PROJECT-24510293
[Journal Article] Monocytic elastase-mediated apolipoprotein-E degradation: Potential involvement of microglial elastase-like proteases in apolipoprotein-E proteolysis in brains with Alzheimer's disease.2015
- Author(s)
  Suenaga M, Furuta A, Wakabayashi K, Saibara T, Matsunaga Y.
- Journal Title
  
  Biochem. Bipohys. Acta.
  
  Volume: 1854 Issue: 8 Pages: 1010-1018
- DOI
  10.1016/j.bbapap.2015.04.028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08631
[Journal Article] Vitamin D2 interacts with human PrPc(90-231) and breaks PrPc oligomerization in vitro2013
- Author(s)
  Modori Suenaga, Yoichi Matsunaga
- Journal Title
  
  PRION
  
  Volume: 7 Issue: 4 Pages: 1-7
- DOI
  10.4161/pri.25739
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590697
[Journal Article] Vitamin D_2 interacts with human PrPc(90-231) and breaks PrPc oligomerization in vitro2013
- Author(s)
  Suenaga M, Hiramoto Y, Matsunaga Y
- Journal Title
  
  PRION
  
  Volume: 7 Pages: 1-7
- Data Source
  KAKENHI-PROJECT-23590697
[Journal Article] Concise synthesis of a probe molecule enabling analysis and imaging of vizantin2013
- Author(s)
  H.Yamamoto, M. Oda, M. Nakano, K. Yabuki, M. Shibutani, T. Nakanishi, M. Suenaga, M. Inoue, H. Imagawa, M. Nagahama, Y. Matsunaga, s. Himeno, K. Setsu, J. Sakurai,M. Nishizawa et al.
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: 61 Pages: 452-459
- NAID
  130003360757
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590697
[Journal Article] L-tryptophan suppresses rise in blood glucose and preserves insulin secretion in Type-2Diabetes Mellitus rats2012
- Author(s)
  T. Inubishi, N. Kamemura, M. Oda, J. Sakurai, Y. Nakaya, N. Harada, M. Suenaga, Y. Matsunaga, K. Ishidoh, N. Katunuma
- Journal Title
  
  J. Nutr. Vitaminol.
  
  Volume: 58 Pages: 415-422
- NAID
  130003368137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590697
[Journal Article] L-Tryptophan Suppresses Rise in Blood Glucose and Preserves Insulin Secretion in Type-2 Diabetes Mellitus Rats2012
- Author(s)
  Inobushi T, Kamemura N, Oda M, Sakurai J, Nakaya Y, Harada N, Suenaga M, Matsunaga Y, Ishidoh K, KatunumaN
- Journal Title
  
  J Nutr. Sci. Vitaminol
  
  Volume: 58 Pages: 415-422
- NAID
  130003368137
- Data Source
  KAKENHI-PROJECT-23590697
[Journal Article] Chemical and genetic diversity of Ligularia virgaurea collected in northern Sichuan and adjacent areas of China. Isoration of 13 new compounds2012
- Author(s)
  Saito Y, Takashima Y, Kamada A, Suzuki Y, Suenaga M, Okamoto Y, Matsunaga Y , Hanai R, Kawahara T, Gong X, Tori M
- Journal Title
  
  Tetrahedron
  
  Volume: 68 Pages: 10011-10029
- Data Source
  KAKENHI-PROJECT-23590697
[Journal Article] Chemical and genetic diversity of Ligularia virgaurea collected in north Shichuan and adjacent areas of China. Isolation of 13 new compounds2012
- Author(s)
  Y. saito, Y. Takashima, A. Kamada, Y. Suzuki, M. Suenaga, Y. Okamoto, Y. Matsunaga, R. Hanai, T. Kawahara, X. Gong, M. Tori
- Journal Title
  
  Tetrahedron
  
  Volume: 68 Pages: 10011-10029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590697
[Journal Article] Environmental factors preceding A-beta40 monomer to oligomers and the function of patients with Parkinson's disease patient serum2012
- Author(s)
  Matsunaga Y, Suenaga M
- Journal Title
  
  J. Amino Acids
  
  Volume: 2012 Pages: 1-8
- Data Source
  KAKENHI-PROJECT-23590697
[Journal Article] Environmental factors preceding A-beta 40 monomer to oligomera and the detection of oligomers in Alzheimer's disease patient serum2012
- Author(s)
  Y. Matsunaga, M. Suenaga
- Journal Title
  
  Journal of Amino Acids
  
  Volume: 2012 Pages: 1-8
- DOI
  10.1155/2012/206520
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590697
[Journal Article] Effects of 8-residue beta sheet breaker peptides on aged A-beta40-induced memory impairment and A-beta40 expression in rat brain and serm following intraamygdaloid injection2010
- Author(s)
  F.Hatip, Y I.Hatip, Matsunaga, M.Suenaga, N.Sen
- Journal Title
  
  Current Alzheimer's Research
  
  Volume: 7 Pages: 602-614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590592
[Journal Article] Effects of 8-residue beta sheet breaker peptides on Aged Aβ40-Induced memory impairment and Aβ40 expression in rat brain and serum following intraamygdaloid injection.2010
- Author(s)
  Hatip F F, Hatip-Al-Khatib I, Y.Matsunaga, M.Suenaga, N.Sen
- Journal Title
  
  Curr Alzheimer Res 7(7)
  
  Pages: 602-614
- Data Source
  KAKENHI-PROJECT-20590592
[Journal Article] THE HDL HANDBOOK ; -Biological Functions and Clinical Implications ; -Chapter 7 : Apolipoprotein A-I Mutations/2010
- Author(s)
  Akira Matsunaga, Yoshinari Uehara, Bo Zhang, Keijiro Saku
- Journal Title
  
  Academic Press (ELSEVIER)
  
  Pages: 133-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590832
[Journal Article] Effects of 8-residue beta-sheet breaker peptides on aged A-beta40 induced memory impariment and A-beta40 expression in rat brain and serum fpllowing intraamygdaloid injection2010
- Author(s)
  Hatip FB, Hatip KA, Matsunaga Y, Suenaga M, Sen N
- Journal Title
  
  Curr. Alz. Res
  
  Volume: 7 Pages: 606-614
- Data Source
  KAKENHI-PROJECT-23590697
[Journal Article] Reversal of temperature-induced conformational changes in the Amyloid-beta peptide, Aβ40, by the β-sheet breaker peptides 16-23 and 17-24.2009
- Author(s)
  Hatip B.F, M.Suenaga, T.Yamada, Y.Matsunaga
- Journal Title
  
  Br J Pharmacol 158
  
  Pages: 1165-1172
- Data Source
  KAKENHI-PROJECT-20590592
[Journal Article] Reversal of temperature-induced conformational changes in the amyloid-beta peptides, A-beta40, by the beta-sheet breaker peptides 16-23 and 17-242009
- Author(s)
  Funda Bolukbasi Hatip, Midori Suenaga, Tatsuo Yamada, Yoichi Matsunaga
- Journal Title
  
  British Journal of Pharmacology 158
  
  Pages: 1165-1172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590592
[Journal Article] Specific reactivity of mild/severe Alzheimer's disease patient's serato antibody against Aβ1-40 epitope 17-212008
- Author(s)
  Hatip F., Matsunaga Y., YamadaT.
- Journal Title
  
  Acta.Neurol.Scand. 117(in press)
  
  Pages: 404-408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590857
[Journal Article] Specific reactivity of mild/severe Alzheimer's disease patient's sera to antibody against Aβ1-40 epitope 17-212008
- Author(s)
  Hatip F., Matsunaga Y., Yamada T.
- Journal Title
  
  Acta.Neurol.Scand. (In press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590857
[Journal Article] Specific reactivity of mild severe Alzheimer's disease patient's sera to antibody against A-betal-40 epitope 17-212007
- Author(s)
  Funda Bolukbasi Hatip, Yoichi Matsunaga, Tatsuo Yamada
- Journal Title
  
  Acta Neurologica Acandinavica 117
  
  Pages: 404-408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590592
[Journal Article] Specific reactivity of mild/severe Alzheimer's disease patient's sera to antibody against Aβ17-212007
- Author(s)
  Hatip F., Matsunaga Yoichi, Yamada T.
- Journal Title
  
  Acta. Neurol . Scand. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590857
[Journal Article] Hydrolytic activity of amrloid-beta and its inhibition with short peptides2005
- Author(s)
  Yoichi Matsunaga
- Journal Title
  
  Curr.Med.Chem-Central Nervous system (Review) (in press)
- Data Source
  KAKENHI-PROJECT-16590857
[Journal Article] Amyloid-beta causes apoptosis of neuronal cells via caspase cascade,which can be prevented by Amyloid-beta-derived short peptides2005
- Author(s)
  Awasthi A., Matsunaga Y., Yamada T.
- Journal Title
  
  Exp.Neurol. 196
  
  Pages: 282-289
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590857
[Journal Article] Hydrolytic activity of Aβ and its inhibition with short peptides2005
- Author(s)
  Yoichi Matsunaga, Tatsuo Yamada
- Journal Title
  
  Curr.Med.Chem.-Central Nervous System Agents 5
  
  Pages: 165-170
- Data Source
  KAKENHI-PROJECT-16590857
[Journal Article] Conformational changes preceeding Amyloid-fibril formation of Aβ, prion protein and stefin B : parallels in pH dependence.2005
- Author(s)
  Yoichi Matsunaga, Tatsuo Yamada
- Journal Title
  
  Med.Chem.Review-On line 2
  
  Pages: 359-367
- Data Source
  KAKENHI-PROJECT-16590857
[Journal Article] Conformational changes preceeding amyloid-fibril formation of amyloid-beta, prion protein and stefin B ; Paralles in pH dependence2005
- Author(s)
  Yoichi Matsunaga
- Journal Title
  
  Med.Chem. -On line Review (in press)
- Data Source
  KAKENHI-PROJECT-16590857
[Journal Article] Amyloid-beta causes apoptosis of neuronal cells via caspase cascades which can be prevented by amyloid-beta derived short peptides2005
- Author(s)
  AwasthiA., Matsunaga Y., Yamada T.
- Journal Title
  
  Exp. Neurol. 19
  
  Pages: 282-289
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590857
[Journal Article] Aβ causes apoptosis of neuronal cells via caspase cascade, which can be prevented by Aβ- derived short peptides.2005
- Author(s)
  Yoichi Matsunaga, Tatsuo Yamada, Yoichi Matsunaga, Tatsuo Yamada
- Journal Title
  
  Experimental Neurology 196
  
  Pages: 282-289
- Data Source
  KAKENHI-PROJECT-16590857
[Journal Article] Eight-residue A-beta inhibit the aggregation and enzymatic activity of A-beta422004
- Author(s)
  Matsunaga Y., Fujii A., Awasthi A., Yokotani J., Takakura T., Yamada T.
- Journal Title
  
  Regul.Peptide 120
  
  Pages: 227-236
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590857
[Journal Article] Eight-residue A-beta inhibit the aggregation and enzymatic activity of A-beta 42.2004
- Author(s)
  Matsunaga Y., Fujii A., Awasthi A., Yokotani J., Takakura T., Yamada T.
- Journal Title
  
  Regul. Peptide. 120
  
  Pages: 227-236
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590857
[Journal Article] Eight-residue A-beta peptides inhibit the aggregation and enzymatic activity of A-beta422004
- Author(s)
  Yoichi Matsunaga
- Journal Title
  
  Regul.Peptides 120
  
  Pages: 227-236
- Data Source
  KAKENHI-PROJECT-16590857
[Journal Article] Reversal of temperature-induced conformational changes in the amyloid-beta peptide, Aβ40, by the β-sheet breaker peptides 16-23 and 17-24.
- Author(s)
  F.Hatip, M.Suenaga, T.Yamada, Y.Matsunaga
- Data Source
  KAKENHI-PROJECT-20590592
[Presentation] パーキンソン病患者に対する卓球リハビリテーション療法の有効性および安全性の検討2021
- Author(s)
  井上賢一、藤岡伸助、長城晃一、末永みどり、木村一喜、米倉有希子、山口良樹、北野晃祐、今村律子、上原吉就、菊池仁志、松永洋一、坪井義夫
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-18K11009
[Presentation] ビタミンＤ２によるアミロイドベータのベータシート構造形成誘導に関与するアミノ酸残基の検索2016
- Author(s)
  末永みどり、松永洋一
- Organizer
  第　　日本薬学会
- Place of Presentation
  横浜市
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K08631
[Presentation] ビタミンＤ２によるアミロイドベータのベータシート構造形成誘導に関与するアミノ酸残基の検索2015
- Author(s)
  末永みどり、松永洋一
- Organizer
  第８８回日本生化学会
- Place of Presentation
  神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K08631
[Presentation] ビタミンDのアミロイドβおよび正常プリオン蛋白との親和性2013
- Author(s)
  末永みどり, 高村佳香, 平本雄介, 藤澤恵美, 高橋宏暢, 松永洋一
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜市
- Year and Date
  2013-09-11
- Data Source
  KAKENHI-PROJECT-23590697
[Presentation] ビタミンＤのアミロイドベータおよびプリオン蛋白への親和性2013
- Author(s)
  末永みどり、松永洋一
- Organizer
  日本生化学会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-23590697
[Presentation] ヒト単球由来ApoE分解酵素の探索2012
- Author(s)
  末永みどり, 西原利治, 松永洋一
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡市
- Year and Date
  2012-12-16
- Data Source
  KAKENHI-PROJECT-23590697
[Presentation] 高濃度Vitamine D2によるベータアミロイド凝の集促進2011
- Author(s)
  末永みどり、松永洋一、合馬信二、山田達夫
- Organizer
  日本老年病学会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-20590592
[Presentation] Amyloidβ凝集に対するVitamin D_2の効果.末永みどり2011
- Author(s)
  石川隼, 高村佳香, 合馬慎二, 山田達夫, 松永洋一
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都市
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-23590697
[Presentation] Reversal of temperature-induced conformational changes in A-beta40 by beta-breaker peptides 16-23 and 17-24.2010
- Author(s)
  M.Suenaga, T.Yamada, Y.Matsunaga
- Organizer
  第82回日本生化学会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-20590592
[Presentation] β-sheet breaker peptides 16-23及び17-24による温度誘導性Aβ40構造変化の抑制2009
- Author(s)
  末永みどり、松永洋一
- Organizer
  第82回日本生化学会
- Place of Presentation
  神戸市
- Year and Date
  2009-10-21
- Data Source
  KAKENHI-PROJECT-20590592
[Presentation] In vivo reversal of memory impairment and cellular Changes induced by aged A-beta40 by breaker peptide Bilaterally injected into rat amygdale.2007
- Author(s)
  Matsunaga Y., Bolukbasi E., Kaya CZ., Gurdal N., Hatip I.
- Organizer
  8th International conference AD/PD
- Place of Presentation
  Salzburg
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590857
[Presentation] In vivo reversal of memory impairment and cellular changes induced by aged A-beta40 by breaker peptides bilaterally injected into rat Amygdale2007
- Author(s)
  Matsunaga Y., Bolukbasi E., Kaya CZ., Gurdal N., Hatip I.
- Organizer
  8th international conference AD/PD
- Place of Presentation
  Salzburg
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590857
[Presentation] ヒト単球由来ApoE分解酵素の探索
- Author(s)
  末永みどり、西原利治、松永洋一
- Organizer
  第８５回日本生化学会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-23590697
[Presentation] アミロイドベータ凝集に対するビタミンＤ２の効果
- Author(s)
  末永みどり、石川隼人、高村佳香、会馬慎二、山田達夫、松永洋一
- Organizer
  日本生化学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23590697

1. UEHARA Yoshinari (70373149)

# of Collaborated Projects: 6 results

# of Collaborated Products: 2 results
2. SAKU Keijiro (40183371)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
3. SUENAGA Midori (00389181)

# of Collaborated Projects: 4 results

# of Collaborated Products: 41 results
4. TSUBOI Yoshio (90291822)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
5. YAMADA Tatsuo (60159217)

# of Collaborated Projects: 2 results

# of Collaborated Products: 22 results
6. YAMADA Tatsuo (50142211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TAKAHASHI Hironobu (90289314)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 毛利資郎 (40117271)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 藤木富士夫 (60352259)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 古田晶子 (50229118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 田中宏暁 (00078544)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 檜垣靖樹 (10228702)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 川中健太郎 (80339960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 松村剛 (20398192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 久保美和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MATSUNAGA Yoichi 松永 洋一

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Development of early diagnosis, prevention, and treatment for neurodegenerative diseases by vitamins

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Beneficial effects of aerobic exercise on HDL metabolism and cellular mitochondria function by an improvement of HDL function.

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Serum vitamin D concentration is a biomarker for early stage of Alzheimer's disease and control amyliod-beta aggregation.Principal Investigator

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Development of a novel gene transferable HDL-generating peptide.

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Developments of diagnostics for Mild Cognitive Impairment by patients serum and inhibition of the disease progress with vitamin DPrincipal Investigator

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Establishment of a novel therapeutic strategyfor atherosclerosis via soluble lipid transporter.

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A new diagnostic approach of Alzheimer's Disease based on the conformational changes of Aβ in serumPrincipal Investigator

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A novel function of membrane cholesterol transporter and a therapeutic strategy for atherosclerosis

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A role of spleen in the conformational transition of prion proteinPrincipal Investigator

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[Book] Vitamin D:Vitamin Daffects neuronal peptides in neurodegenerative sdisease; Differences of VD2 and VD3 for affinity to amyloid-beta and scrapie prion protein in vitro.2016

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[Book] Biological Functions and Clinical Implications; ApoA-I Mutations2010

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[Journal Article] Role of cytochrome P450 for vitamin D metabolisms in patients with neurodegenerative disorders2022

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[Journal Article] Circulatory 25(OH)D and 1,25(OH)2D as differential biomarkers between multiple system atrophy and Parkinson's disease patients2021

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[Journal Article] A novel diagnostic marker for progressive supranuclear palsy targeting atrophy of the subthalamic nucleus2021

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MATSUNAGA Yoichi 松永洋一