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Murata Taku  村田 琢

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MURATA Taku  村田 琢

村田 琢  ムラタ タク

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Researcher Number 80242965
Other IDs
Affiliation (Current) 2025: 三重大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help 2006 – 2024: Mie University, Hospital, Oral and Maxillofacial Surgery, Assistant Professor
2008: Mie University, 医学部・附属病院, 講師
2002 – 2006: Mie University, Medicine, instructor, 医学部附属病院, 助手
2000 – 2001: 三重大学, 医学部・附属病院, 助手
1997 – 1998: 三重大学, 医学部・附属病院, 助手
Review Section/Research Field
Principal Investigator
Surgical dentistry / Basic Section 57060:Surgical dentistry-related / Surgical dentistry / 病態科学系歯学(含放射線系歯学)
Except Principal Investigator
Surgical dentistry / Basic Section 57060:Surgical dentistry-related / Surgical dentistry
Keywords
Principal Investigator
phosphodiesterase / cAMP / melanoma / osteoblast / 骨芽細胞 / 唾液腺 / 悪性黒色腫 / compartmentalization / phosphodiesterase 8 / phosphodiesterase 3 … More / phophodiesterase 8 / phophodiesterase 3 / phosphodiesterase8 / phosphodiesterase3 / phosphodiesteruse / 唾液 / 鳥インフルエンザ / 誤嚥性肺炎 / 分子標的薬 / 遺伝子導入 / siRNA / Phosphodiesterase / cGIPDE … More
Except Principal Investigator
phosphodiesterase / 悪性黒色腫 / 悪性腫瘍 / Phosphodiesterase / melanoma / Novel apoptotic pathway / gene therapy / シグナル遺伝子療法 / Bcl-2 family / Pl-3 kinase / melanoma cell / apoptosis / β_2-microglobulin / 等電点蛋白分取電気泳動 / 腫瘍増殖因子 / beta2 microglobulin / PI-3 kinase / bcl-2 family / beta 2 microglobulin / 腫瘍増殖抑制因子 / シグナル伝達 / 癌 / メラノブラスト / メラノサイト / ES細胞 / 分化 / phosphpodiesterase / phosphodicsterase / phosphodiesterase 2 / 悪性黒色腫細胞 / 運動能 / phosphodiesterase2 / 骨肉腫 / オーダーメイド治療 / 口腔癌 Less
  • Research Projects

    (19 results)
  • Research Products

    (27 results)
  • Co-Researchers

    (5 People)
  •  Phosphodiesterase 1を標的とした口腔悪性黒色腫新規治療法の開発

    • Principal Investigator
      清水 香澄
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Mie University
  •  A new treatment for malignant melanoma based on the concept of compartmentalization of cAMP-PDE2 signal transductionPrincipal Investigator

    • Principal Investigator
      村田 琢
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Mie University
  •  Studies for a new treatment for oral malignant melanoma using PDE1 as a molecular target

    • Principal Investigator
      Shimizu Kasumi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Mie University
  •  Search for novel personalized therapies targeting the PDE2 intracellular signaling complex in malignanciesPrincipal Investigator

    • Principal Investigator
      MURATA TAKU
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Mie University
  •  Studies for clinical application of PDE1 inhibitors to the treatment of malignant melanoma

    • Principal Investigator
      Shimizu Kasumi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Mie University
  •  Development of novel therapeutic methods for malignant tumors targeting PDE2 gene mutationPrincipal Investigator

    • Principal Investigator
      MURATA TAKU
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Mie University
  •  Elucidation of metastasis regulation mechanism of oral malignant melanoma by phosphodiesterase 1 inhibitor for novel therapeutic method

    • Principal Investigator
      Shimizu Kasumi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Mie University
  •  Development of new therapeutic method of novel influenza by the promotion of salivary protein synthesis and secretion by PDEPrincipal Investigator

    • Principal Investigator
      MURATA TAKU
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Surgical dentistry
    • Research Institution
      Mie University
  •  Phosphodiesterase 5 inhibitor, using for erectile dysfunction treatment, may use the treatment of melanoma

    • Principal Investigator
      SHIMIZU Kasumi
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Mie University
  •  Development of new therapeutic method of aspiration pneumonitis on saliva protein promoting by PDEPrincipal Investigator

    • Principal Investigator
      MURATA TAKU
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Surgical dentistry
    • Research Institution
      Mie University
  •  PDE2 related signal・gene therapy on oral malignant tumor

    • Principal Investigator
      TAGAWA Toshiro
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Mie University
  •  ES細胞分化でのphosphodiesteraseの役割

    • Principal Investigator
      田川 俊郎
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Surgical dentistry
    • Research Institution
      Mie University
  •  Development of molecular targeted drugs for DIF・PDE signals inmalignant melanoma cellsPrincipal Investigator

    • Principal Investigator
      MURATA Taku
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Mie University
  •  口腔癌でのPDE関連診断法の確立-オーダーメイド治療に向かって-

    • Principal Investigator
      TAGAWA Toshiro
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Surgical dentistry
    • Research Institution
      Mie University
  •  FDE related signal gene therapy especially melanoma

    • Principal Investigator
      TAGAWA Toshiro
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Mie University
  •  Study of Phosphodiesterase in OsteoblastPrincipal Investigator

    • Principal Investigator
      MURATA Taku
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Mie University
  •  Study of phosphodiesterase in osteoblastPrincipal Investigator

    • Principal Investigator
      MURATA Taku
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Mie University
  •  The study of tumor growth inhibiting activity purified from conditioned medium of human malignant melanoma cells

    • Principal Investigator
      INUI Madoka
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Mie University
  •  唾液腺におけるcGIPDEのクローニングPrincipal Investigator

    • Principal Investigator
      村田 琢
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      病態科学系歯学(含放射線系歯学)
    • Research Institution
      Mie University

All 2023 2021 2019 2017 2015 2014 2013 2012 2011 2009 2008 2007 2006

All Journal Article Presentation

  • [Journal Article] Role of Phosphodiesterase2A in Proliferation and Migration of Human Osteosarcoma Cells2019

    • Author(s)
      Murata T, Shimizu K, Kurohara K, Tomeoku A, Koizumi G, Arai N.
    • Journal Title

      Anticancer research

      Volume: 39 Issue: 11 Pages: 6057-6062

    • DOI

      10.21873/anticanres.13812

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K09720
  • [Presentation] 口腔悪性黒色腫細胞におけるphosphodiesterase 1C1の運動能への影響2023

    • Author(s)
      清水香澄,村田 琢,小泉 岳,滝川 享,新井直也
    • Organizer
      第59回日本口腔組織培養学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-21K10068
  • [Presentation] 口腔悪性黒色腫細胞における ホスホジエステラーゼ1C遺伝子のバリアントの発現2023

    • Author(s)
      清水香澄、村田 琢、小泉 岳、滝川 享、伊藤 希、山田梨奈、新井直也
    • Organizer
      第77回NPO法人日本口腔科学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-21K10068
  • [Presentation] 口腔悪性黒色腫細胞におけるPDE1の発現と悪性度への影響2021

    • Author(s)
      清水香澄、村田琢、小泉岳、新井直也
    • Organizer
      第57回日本口腔組織培養学会学術大会
    • Data Source
      KAKENHI-PROJECT-21K10068
  • [Presentation] 口腔悪性黒色腫クローン細胞におけるphosphodiesterase2遺伝子発現と細胞浸潤の研究2019

    • Author(s)
      村田 琢、清水香澄、留奥 曜、小泉 学、新井直也
    • Organizer
      第64回日本口腔外科学会総会・学術大会
    • Data Source
      KAKENHI-PROJECT-18K09720
  • [Presentation] 口腔骨肉腫細胞におけるphosphodiesterase2の細胞増殖と運動能への役割2019

    • Author(s)
      村田 琢、清水香澄、黒原一人、留奥 曜、小泉 岳、 新井直也
    • Organizer
      第56回日本口腔組織培養学会学術大会
    • Data Source
      KAKENHI-PROJECT-18K09720
  • [Presentation] 口腔悪性黒色腫細胞における phosphodiesterase 2 遺伝子変異と細胞浸潤に関する基礎的研究2017

    • Author(s)
      村田 琢,清水香澄,稲垣俊弘,留奥 曜,黒原一人,新井直也
    • Organizer
      第71回NPO法人日本口腔科学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K11241
  • [Presentation] 悪性黒色腫細胞におけるcAMPシグナルの細胞骨格への影響2017

    • Author(s)
      清水香澄、村田 琢、稲垣俊弘、 黒原一人、新井直也
    • Organizer
      第54 回日本口腔組織培養学会学術大会
    • Data Source
      KAKENHI-PROJECT-15K11242
  • [Presentation] Phosphodiesterase 2遺伝子変異による口腔悪性黒色腫細胞の浸潤能亢進に関する予備的研究2015

    • Author(s)
      森田 寛,清水香澄,朽名智彦,奥村健哉,村田 琢,新井直也
    • Organizer
      第52回日本口腔組織培養学会学術大会
    • Place of Presentation
      徳島大学( 徳島県 ・ 徳島市 )
    • Year and Date
      2015-11-21
    • Data Source
      KAKENHI-PROJECT-15K11241
  • [Presentation] PDE 阻害剤 Sildenafil による悪性黒色腫細胞の運動能の抑制に関する研究2015

    • Author(s)
      清水香澄、森田 寛、村田 琢、奥村健哉、乾 眞登可、新井直也
    • Organizer
      第60回日本口腔外科学会総会・学術大会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-10-16
    • Data Source
      KAKENHI-PROJECT-15K11242
  • [Presentation] 悪性黒色腫細胞の運動と浸潤能への cAMPシグナルの関与 -PKA及びPDE阻害剤を用いた研究2014

    • Author(s)
      清水香澄,村田 琢,中村千穂,若林宏紀,関田素子,森田 寛,松村佳彦,新井直也
    • Organizer
      第59回日本口腔外科学会総会
    • Place of Presentation
      千葉、幕張メッセ
    • Year and Date
      2014-10-18
    • Data Source
      KAKENHI-PROJECT-23592919
  • [Presentation] In Vitro Effects of a Phosphodiesterase Inhibitor Sildenafil on Cellular Motility of the Oral Malignant Melanoma Cells2014

    • Author(s)
      清水香澄,村田 琢,森田 寛,乾眞登可,新井直也
    • Organizer
      第2回日米韓口腔顎顔面外科学会
    • Place of Presentation
      USA, Honolulu,Hawaii convention center
    • Year and Date
      2014-09-11
    • Data Source
      KAKENHI-PROJECT-23592919
  • [Presentation] 口腔由来悪性黒色腫細胞でのBRAF、 PDE5Aシグナルと浸潤との関係2013

    • Author(s)
      清水香澄、村田 琢、乾 眞登可、森田 寛、新井直也、田川俊郎
    • Organizer
      日本口腔組織培養学会設立50周年記念学術大会・総会
    • Place of Presentation
      日本歯科大学生命歯学部
    • Data Source
      KAKENHI-PROJECT-23592919
  • [Presentation] 口腔悪性黒色腫に対するPhosphodiesterase阻害剤sildenafilの運動能抑制効果2013

    • Author(s)
      清水香澄、村田 琢、加藤英治、関田素子、松谷博人、渡邉由裕、野村城二
    • Organizer
      第58回日本口腔外科学会総会・学術大会
    • Place of Presentation
      福岡国際会議場
    • Data Source
      KAKENHI-PROJECT-23592919
  • [Presentation] Expression of phosphodiesterase3 in isolated rat submandibular cells2012

    • Author(s)
      関田 素子、清水 香澄、村田 琢、田川俊郎, 他
    • Organizer
      日中歯科医学大会
    • Place of Presentation
      錦江賓館(中国・成都市)
    • Data Source
      KAKENHI-PROJECT-23659943
  • [Presentation] EXPRESSION OF PHOSPHODIESTERASE3 IN ISOLATED RAT SUBMANDIBULAR CELLS2012

    • Author(s)
      M. Sekida, K. Shimizu, T. Murata, Y. Watanabe, J. Nomura, T. Tagawa
    • Organizer
      日中歯科医学大会
    • Place of Presentation
      中国 成都
    • Data Source
      KAKENHI-PROJECT-23659943
  • [Presentation] 口腔由来悪性黒色腫PMP細胞でのPDE2特異的阻害剤の効果.2011

    • Author(s)
      森田寛, 村田琢, 清水香澄, 渡邉由裕, 田川俊郎
    • Organizer
      第29回日本口腔腫瘍学会総会.
    • Place of Presentation
      熊本.
    • Year and Date
      2011-01-28
    • Data Source
      KAKENHI-PROJECT-20390513
  • [Presentation] B16メラノーマ細胞での Phosphodiesterase4 による浸潤能への影響2009

    • Author(s)
      渡邉由裕, 村田琢, 奥村健哉, 平本憲一, 野村城二, 田川俊郎
    • Organizer
      第46回日本口腔培養学会
    • Place of Presentation
      東京
    • Year and Date
      2009-12-05
    • Data Source
      KAKENHI-PROJECT-20659313
  • [Presentation] ヒト口蓋由来悪性黒色腫細胞でのcGMP-stimulated phosphodiesteraseの発現とシークエンス.2009

    • Author(s)
      森田寛, 清水香澄, 村田琢, 田川俊郎.
    • Organizer
      第37回三重歯科・口腔外科学会
    • Place of Presentation
      三重.
    • Year and Date
      2009-12-13
    • Data Source
      KAKENHI-PROJECT-20390513
  • [Presentation] ヒト口蓋由来悪性黒色腫細胞でのcGMP-stimulated phosphodiesteraseの発現とシークエンス2009

    • Author(s)
      森田寛, 清水香澄, 村田琢, 田川俊郎
    • Organizer
      第37回三重歯科・口腔外科学会
    • Place of Presentation
      三重
    • Year and Date
      2009-12-13
    • Data Source
      KAKENHI-PROJECT-20390513
  • [Presentation] B16メラノーマ細胞でのcAMPによる運動能への影響2009

    • Author(s)
      渡邉由裕, 村田琢, 佐藤忠, 鈴木智子, 岩崎佳見, 関田素子, 奥村健哉, 田川俊郎
    • Organizer
      第34回日本口腔外科学会中部地方会
    • Place of Presentation
      福井
    • Year and Date
      2009-05-16
    • Data Source
      KAKENHI-PROJECT-20659313
  • [Presentation] 悪性黒色腫細胞へのphosphodiestearase 2A遺伝子導入2008

    • Author(s)
      村田琢, 清水香澄, 森田寛, 渡辺由裕, 関田素子, 野村城二, 乾真登可, 田川俊郎
    • Organizer
      第45回口腔組織培養学会
    • Place of Presentation
      松本
    • Year and Date
      2008-11-15
    • Data Source
      KAKENHI-PROJECT-18390537
  • [Presentation] Toshiro Tagawa Relationship between Phosphodiesterase2 and Growth in Oral Malignant Melanoma cells.2008

    • Author(s)
      Kasumi Shimizu, Kenichi Hiramoto, Taku Murata, Yoshihiro Watanabe, Madoka Inui
    • Organizer
      9th Asian Congress on Oral and Maxillofacial Surgery
    • Place of Presentation
      Bangkok, Thailand.
    • Year and Date
      2008-11-06
    • Data Source
      KAKENHI-PROJECT-20390513
  • [Presentation] 悪性黒色腫細胞株でのPDE5阻害剤での影響2007

    • Author(s)
      清水香澄, 村田琢, 成田素, 山本紗野子, 平本憲一, 奥村健哉, 田川俊郎
    • Organizer
      第32回日本口腔外科学会中部地方会
    • Place of Presentation
      金沢
    • Year and Date
      2007-05-26
    • Data Source
      KAKENHI-PROJECT-18390537
  • [Presentation] 口腔由来悪性黒色腫細胞での(:AMP-PDEシグナルと細胞浸潤2007

    • Author(s)
      平本 憲一, 村田 琢, 中瀬 実, 藤井 祐野村 城二, 乾屓 登可, 田川 俊郎
    • Organizer
      第52回日本口腔外科学会総会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2007-09-29
    • Data Source
      KAKENHI-PROJECT-17659631
  • [Presentation] Study of cGMP-related phospodiesterasein human oral malignat melanoma cell line2007

    • Author(s)
      Kasumi Shimizu, Taku Murata, YoshihiroWatanabe, Kenichi Hiramoto, Motoko Sekida,Toshiro Tagawa
    • Organizer
      18th International Conference on Oral and Maxillofacial Surgery
    • Place of Presentation
      Bangalore, India
    • Year and Date
      2007-11-14
    • Data Source
      KAKENHI-PROJECT-18390537
  • [Presentation] Phosphodiesterase (PDE) 7 in human oralmalignamt melanoma cell lines2006

    • Author(s)
      Kasumi Shimizu, Taku Murata, Madoka Inui, Kenichi Hiramoto, Tasuku Fujii, TakayukiNagata, Toshiro Tagawa
    • Organizer
      11th International Congress on Oral Cancer
    • Place of Presentation
      Grado, Bitaly
    • Year and Date
      2006-05-15
    • Data Source
      KAKENHI-PROJECT-18390537
  • 1.  SHIMIZU Kasumi (20378368)
    # of Collaborated Projects: 14 results
    # of Collaborated Products: 24 results
  • 2.  TAGAWA Toshiro (30046346)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 13 results
  • 3.  INUI Madoka (70159961)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  NOMURA Zouji (80172815)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  成田 素 (70362340)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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