Murata Taku 村田琢

… Alternative Names

Researcher Number	80242965
Other IDs
Affiliation (Current)	2020: 三重大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2006 – 2019: Mie University, Hospital, Oral and Maxillofacial Surgery, Assistant Professor 2008: Mie University, 医学部・附属病院, 講師 2002 – 2006: Mie University, Medicine, instructor, 医学部附属病院, 助手 2000 – 2001: 三重大学, 医学部・附属病院, 助手 1997 – 1998: 三重大学, 医学部・附属病院, 助手
Review Section/Research Field	Principal Investigator Surgical dentistry / 病態科学系歯学(含放射線系歯学) / Surgical dentistry / Basic Section 57060:Surgical dentistry-related Except Principal Investigator Surgical dentistry / Surgical dentistry / Basic Section 57060:Surgical dentistry-related
Keywords	Principal Investigator phosphodiesterase / cAMP / 悪性黒色腫 / 唾液腺 / 骨芽細胞 / osteoblast / melanoma / cGIPDE / Phosphodiesterase / siRNA … More Except Principal Investigator 悪性黒色腫 / phosphodiesterase / 悪性腫瘍 / Phosphodiesterase / Novel apoptotic pathway / melanoma / 口腔癌 / オーダーメイド治療 / 骨肉腫 / phosphodiesterase2 / 運動能 / 悪性黒色腫細胞 / phosphodiesterase 2 / phosphodicsterase / phosphpodiesterase / 分化 / ES細胞 / メラノサイト / メラノブラスト / 癌 / シグナル伝達 / 腫瘍増殖抑制因子 / beta 2 microglobulin / bcl-2 family / PI-3 kinase / beta2 microglobulin / 腫瘍増殖因子 / 等電点蛋白分取電気泳動 / β_2-microglobulin / apoptosis / melanoma cell / Pl-3 kinase / Bcl-2 family / シグナル遺伝子療法 / gene therapy Less

悪性腫瘍におけるPDE2細胞内情報伝達複合体を標的とした新規個別化治療の探索Principal InvestigatorOngoing
- Principal Investigator
  
  村田琢
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Mie University
口腔悪性黒色腫新治療薬の開発-PDE1阻害剤の臨床応用を目指してOngoing
- Principal Investigator
  
  清水香澄
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Mie University
Development of novel therapeutic methods for malignant tumors targeting PDE2 gene mutationPrincipal Investigator
- Principal Investigator
  
  MURATA TAKU
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Mie University
Elucidation of metastasis regulation mechanism of oral malignant melanoma by phosphodiesterase 1 inhibitor for novel therapeutic method
- Principal Investigator
  
  Shimizu Kasumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Mie University
Development of new therapeutic method of novel influenza by the promotion of salivary protein synthesis and secretion by PDEPrincipal Investigator
- Principal Investigator
  
  MURATA TAKU
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  Mie University
Phosphodiesterase 5 inhibitor, using for erectile dysfunction treatment, may use the treatment of melanoma
- Principal Investigator
  
  SHIMIZU Kasumi
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Mie University
Development of new therapeutic method of aspiration pneumonitis on saliva protein promoting by PDEPrincipal Investigator
- Principal Investigator
  
  MURATA TAKU
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  Mie University
PDE2 related signal・gene therapy on oral malignant tumor
- Principal Investigator
  
  TAGAWA Toshiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Mie University
ES細胞分化でのphosphodiesteraseの役割
- Principal Investigator
  
  田川俊郎
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  Mie University
Development of molecular targeted drugs for DIF・PDE signals inmalignant melanoma cellsPrincipal Investigator
- Principal Investigator
  
  MURATA Taku
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Mie University
口腔癌でのPDE関連診断法の確立-オーダーメイド治療に向かって-
- Principal Investigator
  
  TAGAWA Toshiro
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  Mie University
FDE related signal gene therapy especially melanoma
- Principal Investigator
  
  TAGAWA Toshiro
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Mie University
Study of Phosphodiesterase in OsteoblastPrincipal Investigator
- Principal Investigator
  
  MURATA Taku
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Mie University
Study of phosphodiesterase in osteoblastPrincipal Investigator
- Principal Investigator
  
  MURATA Taku
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Mie University
The study of tumor growth inhibiting activity purified from conditioned medium of human malignant melanoma cells
- Principal Investigator
  
  INUI Madoka
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Mie University
唾液腺におけるcGIPDEのクローニングPrincipal Investigator
- Principal Investigator
  
  村田琢
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Mie University

All 2019 2017 2015 2014 2013 2012 2011 2009 2008 2007 2006

All Journal Article Presentation

[Journal Article] Role of Phosphodiesterase2A in Proliferation and Migration of Human Osteosarcoma Cells2019
- Author(s)
  Murata T, Shimizu K, Kurohara K, Tomeoku A, Koizumi G, Arai N.
- Journal Title
  
  Anticancer research
  
  Volume: 39 Pages: 6057-6062
- DOI
  10.21873/anticanres.13812
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09720
[Presentation] 口腔骨肉腫細胞におけるphosphodiesterase2の細胞増殖と運動能への役割2019
- Author(s)
  村田　琢、清水香澄、黒原一人、留奥　曜、小泉　岳、新井直也
- Organizer
  第56回日本口腔組織培養学会学術大会
- Data Source
  KAKENHI-PROJECT-18K09720
[Presentation] 口腔悪性黒色腫クローン細胞におけるphosphodiesterase2遺伝子発現と細胞浸潤の研究2019
- Author(s)
  村田　琢、清水香澄、留奥　曜、小泉　学、新井直也
- Organizer
  第64回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-18K09720
[Presentation] 悪性黒色腫細胞におけるcAMPシグナルの細胞骨格への影響2017
- Author(s)
  清水香澄、村田　琢、稲垣俊弘、黒原一人、新井直也
- Organizer
  第54 回日本口腔組織培養学会学術大会
- Data Source
  KAKENHI-PROJECT-15K11242
[Presentation] 口腔悪性黒色腫細胞における phosphodiesterase 2 遺伝子変異と細胞浸潤に関する基礎的研究2017
- Author(s)
  村田　琢，清水香澄，稲垣俊弘，留奥　曜，黒原一人，新井直也
- Organizer
  第71回NPO法人日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-15K11241
[Presentation] PDE 阻害剤 Sildenafil による悪性黒色腫細胞の運動能の抑制に関する研究2015
- Author(s)
  清水香澄、森田　寛、村田　琢、奥村健哉、乾　眞登可、新井直也
- Organizer
  第60回日本口腔外科学会総会・学術大会
- Place of Presentation
  名古屋国際会議場(愛知県・名古屋市)
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K11242
[Presentation] Phosphodiesterase 2遺伝子変異による口腔悪性黒色腫細胞の浸潤能亢進に関する予備的研究2015
- Author(s)
  森田　寛，清水香澄，朽名智彦，奥村健哉，村田　琢，新井直也
- Organizer
  第52回日本口腔組織培養学会学術大会
- Place of Presentation
  徳島大学（　徳島県　・　徳島市　）
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PROJECT-15K11241
[Presentation] 悪性黒色腫細胞の運動と浸潤能への cAMPシグナルの関与 -PKA及びPDE阻害剤を用いた研究2014
- Author(s)
  清水香澄,村田　琢,中村千穂,若林宏紀,関田素子,森田　寛,松村佳彦,新井直也
- Organizer
  第59回日本口腔外科学会総会
- Place of Presentation
  千葉、幕張メッセ
- Year and Date
  2014-10-18
- Data Source
  KAKENHI-PROJECT-23592919
[Presentation] In Vitro Effects of a Phosphodiesterase Inhibitor Sildenafil on Cellular Motility of the Oral Malignant Melanoma Cells2014
- Author(s)
  清水香澄,村田　琢,森田　寛,乾眞登可,新井直也
- Organizer
  第2回日米韓口腔顎顔面外科学会
- Place of Presentation
  USA, Honolulu,Hawaii convention center
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-23592919
[Presentation] 口腔由来悪性黒色腫細胞でのBRAF、 PDE5Aシグナルと浸潤との関係2013
- Author(s)
  清水香澄、村田　琢、乾　眞登可、森田　寛、新井直也、田川俊郎
- Organizer
  日本口腔組織培養学会設立50周年記念学術大会・総会
- Place of Presentation
  日本歯科大学生命歯学部
- Data Source
  KAKENHI-PROJECT-23592919
[Presentation] 口腔悪性黒色腫に対するPhosphodiesterase阻害剤sildenafilの運動能抑制効果2013
- Author(s)
  清水香澄、村田　琢、加藤英治、関田素子、松谷博人、渡邉由裕、野村城二
- Organizer
  第58回日本口腔外科学会総会・学術大会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23592919
[Presentation] Expression of phosphodiesterase3 in isolated rat submandibular cells2012
- Author(s)
  関田素子、清水香澄、村田琢、田川俊郎, 他
- Organizer
  日中歯科医学大会
- Place of Presentation
  錦江賓館(中国・成都市)
- Data Source
  KAKENHI-PROJECT-23659943
[Presentation] EXPRESSION OF PHOSPHODIESTERASE3 IN ISOLATED RAT SUBMANDIBULAR CELLS2012
- Author(s)
  M. Sekida, K. Shimizu, T. Murata, Y. Watanabe, J. Nomura, T. Tagawa
- Organizer
  日中歯科医学大会
- Place of Presentation
  中国　成都
- Data Source
  KAKENHI-PROJECT-23659943
[Presentation] 口腔由来悪性黒色腫PMP細胞でのPDE2特異的阻害剤の効果.2011
- Author(s)
  森田寛, 村田琢, 清水香澄, 渡邉由裕, 田川俊郎
- Organizer
  第29回日本口腔腫瘍学会総会.
- Place of Presentation
  熊本.
- Year and Date
  2011-01-28
- Data Source
  KAKENHI-PROJECT-20390513
[Presentation] ヒト口蓋由来悪性黒色腫細胞でのcGMP-stimulated phosphodiesteraseの発現とシークエンス.2009
- Author(s)
  森田寛, 清水香澄, 村田琢, 田川俊郎.
- Organizer
  第37回三重歯科・口腔外科学会
- Place of Presentation
  三重.
- Year and Date
  2009-12-13
- Data Source
  KAKENHI-PROJECT-20390513
[Presentation] B16メラノーマ細胞でのcAMPによる運動能への影響2009
- Author(s)
  渡邉由裕, 村田琢, 佐藤忠, 鈴木智子, 岩崎佳見, 関田素子, 奥村健哉, 田川俊郎
- Organizer
  第34回日本口腔外科学会中部地方会
- Place of Presentation
  福井
- Year and Date
  2009-05-16
- Data Source
  KAKENHI-PROJECT-20659313
[Presentation] B16メラノーマ細胞での Phosphodiesterase4 による浸潤能への影響2009
- Author(s)
  渡邉由裕, 村田琢, 奥村健哉, 平本憲一, 野村城二, 田川俊郎
- Organizer
  第46回日本口腔培養学会
- Place of Presentation
  東京
- Year and Date
  2009-12-05
- Data Source
  KAKENHI-PROJECT-20659313
[Presentation] ヒト口蓋由来悪性黒色腫細胞でのcGMP-stimulated phosphodiesteraseの発現とシークエンス2009
- Author(s)
  森田寛, 清水香澄, 村田琢, 田川俊郎
- Organizer
  第37回三重歯科・口腔外科学会
- Place of Presentation
  三重
- Year and Date
  2009-12-13
- Data Source
  KAKENHI-PROJECT-20390513
[Presentation] Toshiro Tagawa Relationship between Phosphodiesterase2 and Growth in Oral Malignant Melanoma cells.2008
- Author(s)
  Kasumi Shimizu, Kenichi Hiramoto, Taku Murata, Yoshihiro Watanabe, Madoka Inui
- Organizer
  9th Asian Congress on Oral and Maxillofacial Surgery
- Place of Presentation
  Bangkok, Thailand.
- Year and Date
  2008-11-06
- Data Source
  KAKENHI-PROJECT-20390513
[Presentation] 悪性黒色腫細胞へのphosphodiestearase 2A遺伝子導入2008
- Author(s)
  村田琢, 清水香澄, 森田寛, 渡辺由裕, 関田素子, 野村城二, 乾真登可, 田川俊郎
- Organizer
  第45回口腔組織培養学会
- Place of Presentation
  松本
- Year and Date
  2008-11-15
- Data Source
  KAKENHI-PROJECT-18390537
[Presentation] 悪性黒色腫細胞株でのPDE5阻害剤での影響2007
- Author(s)
  清水香澄, 村田琢, 成田素, 山本紗野子, 平本憲一, 奥村健哉, 田川俊郎
- Organizer
  第32回日本口腔外科学会中部地方会
- Place of Presentation
  金沢
- Year and Date
  2007-05-26
- Data Source
  KAKENHI-PROJECT-18390537
[Presentation] 口腔由来悪性黒色腫細胞での(:AMP-PDEシグナルと細胞浸潤2007
- Author(s)
  平本憲一, 村田琢, 中瀬実, 藤井祐野村城二, 乾屓登可, 田川俊郎
- Organizer
  第52回日本口腔外科学会総会
- Place of Presentation
  愛知県名古屋市
- Year and Date
  2007-09-29
- Data Source
  KAKENHI-PROJECT-17659631
[Presentation] Study of cGMP-related phospodiesterasein human oral malignat melanoma cell line2007
- Author(s)
  Kasumi Shimizu, Taku Murata, YoshihiroWatanabe, Kenichi Hiramoto, Motoko Sekida,Toshiro Tagawa
- Organizer
  18th International Conference on Oral and Maxillofacial Surgery
- Place of Presentation
  Bangalore, India
- Year and Date
  2007-11-14
- Data Source
  KAKENHI-PROJECT-18390537
[Presentation] Phosphodiesterase (PDE) 7 in human oralmalignamt melanoma cell lines2006
- Author(s)
  Kasumi Shimizu, Taku Murata, Madoka Inui, Kenichi Hiramoto, Tasuku Fujii, TakayukiNagata, Toshiro Tagawa
- Organizer
  11th International Congress on Oral Cancer
- Place of Presentation
  Grado, Bitaly
- Year and Date
  2006-05-15
- Data Source
  KAKENHI-PROJECT-18390537

1. SHIMIZU Kasumi (20378368)

# of Collaborated Projects: 11 results

# of Collaborated Products: 21 results
2. TAGAWA Toshiro (30046346)

# of Collaborated Projects: 8 results

# of Collaborated Products: 13 results
3. INUI Madoka (70159961)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. NOMURA Zouji (80172815)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 成田素 (70362340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Murata Taku 村田 琢

MURATA Taku 村田 琢

村田 琢 ムラタ タク

Research Projects

Research Products

Co-Researchers

悪性腫瘍におけるPDE2細胞内情報伝達複合体を標的とした新規個別化治療の探索Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

口腔悪性黒色腫新治療薬の開発-PDE1阻害剤の臨床応用を目指してOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel therapeutic methods for malignant tumors targeting PDE2 gene mutationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of metastasis regulation mechanism of oral malignant melanoma by phosphodiesterase 1 inhibitor for novel therapeutic method

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new therapeutic method of novel influenza by the promotion of salivary protein synthesis and secretion by PDEPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Phosphodiesterase 5 inhibitor, using for erectile dysfunction treatment, may use the treatment of melanoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new therapeutic method of aspiration pneumonitis on saliva protein promoting by PDEPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

PDE2 related signal・gene therapy on oral malignant tumor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ES細胞分化でのphosphodiesteraseの役割

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of molecular targeted drugs for DIF・PDE signals inmalignant melanoma cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

口腔癌でのPDE関連診断法の確立-オーダーメイド治療に向かって-

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

FDE related signal gene therapy especially melanoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of Phosphodiesterase in OsteoblastPrincipal Investigator

Principal Investigator

Murata Taku 村田琢

MURATA Taku 村田琢

村田琢ムラタタク