ITOH Kyoko 伊東恭子

Researcher Number	80243301
Other IDs
External Links
Affiliation (Current)	2022: 京都府立医科大学, 医学(系)研究科(研究院), 教授
Affiliation (based on the past Project Information) *help	2015 – 2021: 京都府立医科大学, 医学(系)研究科(研究院), 教授 2011 – 2014: 京都府立医科大学, 医学(系)研究科(研究院), 准教授 2012: 京都府立医科大学, 医学研究科, 准教授 2006 – 2010: 京都府立医科大学, 医学研究科, 准教授 2003 – 2004: 京都府立医科大学, 医学研究科, 助教授 1998 – 2000: 神戸大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Embryonic/Neonatal medicine / Basic Section 52050:Embryonic medicine and pediatrics-related / Human pathology / Environmental impact assessment/Environmental policy Except Principal Investigator Embryonic/Neonatal medicine / Risk sciences of radiation/Chemicals / Laboratory medicine / Applied health science / Medium-sized Section 52:General internal medicine and related fields / Basic Section 55040:Respiratory surgery-related
Keywords	Principal Investigator 先天異常学 / L1CAM / 脳形成異常 / タナトフォリック骨異形成症 / shRNA / in utero electroporation / 胎児医学 / 脳オルガノイド / アルツハイマー病 / 老人斑 … More Except Principal Investigator 内分泌かく乱物質 / ビスフェノールA / 神経幹細胞 / アルツハイマー病 / BrdU / protein disulfide isomerase / マウス / 神経細胞移動 / エピジェネティックス / DNAメチル化 / 大脳 / 肝 / マウス胎仔 / 先天異常学 / 難治性脳形成異常 / 脳オルガノイド / FGFR3 / 胎児医学 / 脳形成障害 / βアミロイド / セクレターゼ / マーカー蛋白 / 老人斑 / βセクレターゼ / セリンプロテアーゼ / 発症前診断 / 天然基質 / ALZHEIMERS DISEASE / β-AMYLOID / SECRETASE / MARKER PROTEIN / SENILE LAQUE / 脳神経系発達 / 遺伝子発現 / マイクロアレイ / 免疫組織化学 / Protein Disulfide Isomerase / endocrine disruptor / bisphenol A / brain development / gene expression / cDNA microarray / immunohistochemistry / 加齢・老化 / ASPM / MRI / 行動表現型 / 合成受容体 / バイオエンジニアリング / 合成アミロイドβ受容体 / アミロイドβ / 遺伝子治療 / 肺癌 / STAS Less

Molecular pathogenesis of brain malformations in de novo postzygotic mutations in the brainPrincipal Investigator
- Principal Investigator
  
  伊東恭子
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto Prefectural University of Medicine
Molecular Mechanism of Spread Through Air Space in Lung Cancer
- Principal Investigator
  
  井上匡美
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Kyoto Prefectural University of Medicine
Development of synthetic Amyloid beta receptor for Alzheimer's disease therapy
- Principal Investigator
  
  Hoshino Atsushi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Kyoto Prefectural University of Medicine
Elucidation of molecular pathomechanisms and the search for therapeutic targets of brain malformations, by employing cerebral organoids generated from patients-derived neural stem/progenitor cellsPrincipal Investigator
- Principal Investigator
  
  Itoh Kyoko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto Prefectural University of Medicine
The functional significance of ASPM, responsible gene for human microcephaly, in the activation of adult neural stem cells - a new approach to brain anti-aging
- Principal Investigator
  
  Tando So
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Kyoto Prefectural University of Medicine
Mechanisms of brain malformations: in vitro analysis using patient-derived neural stem cells
- Principal Investigator
  
  Fushiki Shinji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Kyoto Prefectural University of Medicine
Pathological mechanism of abnormal brain development in thanatophoric dysplasia evaluated by using human fetal brain-derived neural stem cellsPrincipal Investigator
- Principal Investigator
  
  Itoh Kyoko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Kyoto Prefectural University of Medicine
Cell kinetic as well as functional analyses on microcephaly-related gene knockout micePrincipal Investigator
- Principal Investigator
  
  Itoh Kyoko
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Kyoto Prefectural University of Medicine
Analyses on the pathogenesis of L1-associated hydrocephalus by knocking down L1 and TAG-1Principal Investigator
- Principal Investigator
  
  ITOH Kyoko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Kyoto Prefectural University of Medicine
Studies on the effects of prenatal exposure to bisphenol A in mouse brain, with special reference to neuronal migration and epigenetic alteratio ns
- Principal Investigator
  
  FUSHIKI Shinji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Kyoto Prefectural University of Medicine
環境中ナノ粒子の脳老化、神経変性疾患への寄与に関する探索的研究Principal Investigator
- Principal Investigator
  
  伊東恭子
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental impact assessment/Environmental policy
- Research Institution
  Kyoto Prefectural University of Medicine
Analyses on the pathogenesis of hydrocephalus associated with L1CAM-mutation using in utero shRNA silencingPrincipal Investigator
- Principal Investigator
  
  ITOH Kyoko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Kyoto Prefectural University of Medicine
Effects of endocrine disruptors on developing brain, with special reference to gene expression.
- Principal Investigator
  
  FUSHIKI Shinji
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Kyoto Prefectural University of Medicine
Functional significance of L1 cell adhesion molecule in the brain development of L1-mutant micePrincipal Investigator
- Principal Investigator
  
  ITOH Kyoko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Kyoto Prefectural University of Medicine
アルツハイマー病発症に関わるアミロイド前駆体蛋白切断プロテアーゼCPB14の研究Principal Investigator
- Principal Investigator
  
  伊東恭子
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kobe University
APPLICATION OF B-SECRETASE FOR PRESYMPTOMATIC DIAGNOSIS OF ALZHEIMERS DISEASE
- Principal Investigator
  
  MATSUMOTO Akira
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kobe University

All 2018 2013 2012 2011 2010 2009 2008 2005 2004 Other

All Journal Article Presentation

[Journal Article] Longitudinal Diffusion Tensor Imaging Revealed Nerve Fiber Alterations in Aspm Mutated Microcephaly Model Mice2018
- Author(s)
  Ogi Hiroshi、Nitta Nobuhiro、Tando So、Fujimori Akira、Aoki Ichio、Fushiki Shinji、Itoh Kyoko
- Journal Title
  
  Neuroscience
  
  Volume: 371 Pages: 325-336
- DOI
  10.1016/j.neuroscience.2017.12.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K01722
[Journal Article] Disruption of Aspm causes microcephaly with abnormal neuronal differentiation2013
- Author(s)
  Fujimori A, Itoh K, Goto S, Hirakawa H, Wang B, Kokubo T, Koto S, Tsukamoto S, Fushiki S.
- Journal Title
  
  Brain & Development
  
  Volume: -
- DOI
  10.1016/j.braindev.2013.10.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293240
[Journal Article] Prenatal and lactational exposure to low-doses of bisphenol A alters adult mice behavior2012
- Author(s)
  Nakamura K, Itoh K, Dai H, Han L, Wang X, Kato S, Sugimoto T, Fushiki S
- Journal Title
  
  Brain Dev
  
  Volume: 34(1) Pages: 57-63
- NAID
  10031049535
- Data Source
  KAKENHI-PROJECT-20310036
[Journal Article] Bisphenol A, an endocrine-disrupting chemical, and brain development2012
- Author(s)
  Itoh K, Yaoi T, Fushiki S
- Journal Title
  
  Neuropathology
  
  Volume: (オンラインジャーナル)
- DOI
  10.1111/j.1440-1789.2011.01287.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310036, KAKENHI-PROJECT-21300324, KAKENHI-PROJECT-21510072
[Journal Article] Prenatal and lactational exposure to low-doses of bisphenol A alters adult mice behavior.2011
- Author(s)
  Nakamura K, Itoh K, Dai H, Han L, Wang X, Kato S, Sugimoto T, Fushiki S.
- Journal Title
  
  Brain Dev
  
  Volume: (Epub ahead of print)
- NAID
  10031049535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310036
[Journal Article] Prenatal and lactational exposure to bisphenol A in mice alters expression of genes involved in cortical barrel development without morphological changes.2011
- Author(s)
  Han L, Itoh K, Yaoi T, Moriwaki S, Kato S, Nakamura K, Fushiki S.
- Journal Title
  
  Acta Histochem Cytochem
  
  Volume: 44 Pages: 25-33
- NAID
  130000395313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310036
[Journal Article] Prenatal and lactational exposure to bisphenol A in mice alters expression of genes involved in cortical barrel development without morphological changes2011
- Author(s)
  Han L, Itoh K, Yaoi T, Moriwaki S, Kato S, Nakamura K, Fushiki S
- Journal Title
  
  Acta Histochem Cytochem
  
  Volume: 44(1) Pages: 25-33
- NAID
  130000395313
- Data Source
  KAKENHI-PROJECT-20310036
[Journal Article] Prenatal and lactational exposure to low-doses of bisphenol A alters brain monoamine concentration in adult mice2010
- Author(s)
  Nakamura K, Itoh K, Yoshimoto K, Sugimoto T, Fushiki S
- Journal Title
  
  Neurosci Lett
  
  Volume: 484(1) Pages: 66-70
- Data Source
  KAKENHI-PROJECT-20310036
[Journal Article] Prenatal and lactational exposure to low-doses of bisphenol A alters brain monoamine concentration in adult mice.2010
- Author(s)
  Nakamura K, Itoh K, Yoshimoto K, Sugimoto T, Fushiki S
- Journal Title
  
  Neurosci Lett
  
  Volume: 484 Pages: 66-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310036
[Journal Article] 神経疾患のエピジェネティクス2009
- Author(s)
  伊東恭子、伏木信次
- Journal Title
  
  京都府立医科大学雑誌 118
  
  Pages: 523-531
- Data Source
  KAKENHI-PROJECT-20310036
[Journal Article] Genome-wide analysis of epigenomic alterations in fetal mouse forebrain after exposure to low doses of bisphenol A2008
- Author(s)
  Yaoi T, Itoh K, Nakamura K, Ogi H, Fujiwara Y, Fushiki S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 376(3) Pages: 563-7
- Data Source
  KAKENHI-PROJECT-20310036
[Journal Article] Genome-wide analysis of epigenomic alterations in fetal mouse forebrain after exposure to low doses of bisphenol A. 2008 ; 376 : 563-7.2008
- Author(s)
  Yaoi T, Itoh K, Nakamura K, Ogi H, Fujiwara Y, Fushiki S.
- Journal Title
  
  Biochem Biophys Res Commun. 376
  
  Pages: 563-567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310036
[Journal Article] Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans2008
- Author(s)
  Fujimori A, Yaoi T, Ogi H, Wang B, Suetomi K, Sekine E, Yu D, Kato T, Takahashi S, Okayasu R, Itoh K, Fushiki S.
- Journal Title
  
  Biochem Biophys Res Commun 369(3)
  
  Pages: 953-957
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390308
[Journal Article] Spatiotemporal patterns of expression of IGSF4 in developing nervous system.2005
- Author(s)
  Ohta Y, Itoh K, Yaoi T, Tando S, Fukui K, Fushiki S.
- Journal Title
  
  Dev Brain Res (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390334
[Journal Article] Spatiotemporal patterns of expression of IGSF4 in developing nervous system.2005
- Author(s)
  Ohta Y, Itoh K, Yaoi T, Tando A, Fukui K, Fushiki S
- Journal Title
  
  Dev Brain Res (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390334
[Journal Article] Brain development in mice lacking L1-L1 homophilic adhesion.2004
- Author(s)
  Itoh K, Cheng L, Kamei Y, Fushiki S, Kamiguchi H, Gutwein P, Stoeck A, Arnold B, Altevogt P, Lemmon V
- Journal Title
  
  Journal of Cell Biology 165
  
  Pages: 145-154
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591160
[Journal Article] 中枢および末梢神経系発達における神経細胞接着分子(L1CAM)の意義2004
- Author(s)
  伊東恭子
- Journal Title
  
  京府医大誌 113(2)
  
  Pages: 69-82
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591160
[Journal Article] Functional significance of L1 cell adhesion molecule in the development of central and peripheral nervous systems.2004
- Author(s)
  Kyoko Itoh
- Journal Title
  
  J.Kyoto Pref.Univ.Med. 113(2)
  
  Pages: 69-82
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591160
[Journal Article] Model animals for X-linked hydrocephalus.2004
- Author(s)
  Kyoko Itoh, Hiroyuki Kamiguchi
- Journal Title
  
  CELL TECHNOLOGY 23(12)
  
  Pages: 1414-1417
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591160
[Journal Article] Brain development in mice lacking L1-L1 homophilic adhesion.2004
- Author(s)
  Itoh K, Cheng L, Kamei Y, Fushiki S, Kamiguchi H, Gutwein P, Stoeck A, Arnold B, Altevogt P, Lemmon V
- Journal Title
  
  Journal of Cell Biology 165(1)
  
  Pages: 145-154
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591160
[Journal Article] X連鎖性遺伝性水頭症のモデル動物2004
- Author(s)
  伊東恭子, 上口裕之
- Journal Title
  
  細胞工学 23(12)
  
  Pages: 1414-1417
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591160
[Journal Article] Downregulation of L1 perturbs neuronal migration and alters the expression of transcription factors in murine neocortex
- Author(s)
  Kishimoto T, Itoh K, Umekage M, Tonosaki M, Yaoi T, Fukui K, Fushiki S.
- Journal Title
  
  J. Neurosci. Res
  
  Volume: 91 Pages: 42-50
- DOI
  10.1002/jnr.23141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390214
[Presentation] Hippocampal adult neurogenesis is perturbed in microcephaly model mice with aging2018
- Author(s)
  Takahashi H , Fujimori A , Tando S , Mori M , Fushiki S , Itoh K
- Organizer
  19th International Congress of Neuropathology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01722
[Presentation] Longitudinal diffusion tensor imaging and neuropathology revealed nerve fiber alterations in hereditary microcephaly model mice2018
- Author(s)
  Ogi H, Nitta N, Tando S, Fujimori A, Aoki I, Fushiki S, Itoh K
- Organizer
  19th International Congress of Neuropathology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01722
[Presentation] Longitudinal diffusion tensor imaging revealed nerve fiber alterations in Aspm mutated microcephaly model mice2018
- Author(s)
  Ogi H, Nitta N, Shibata S, Tando S, Fjimori A, Aoki I, Fushiki S, Itoh K
- Organizer
  22nd Biennial Meeting of the International Society for Developmental Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01722
[Presentation] 脳形成障害の発生病理解明-遺伝要因と環境要因に着目して2013
- Author(s)
  伊東恭子
- Organizer
  第59回日本病理学会秋期特別総会 A 演説.
- Place of Presentation
  甲府市
- Data Source
  KAKENHI-PROJECT-22390214
[Presentation] 脳形成障害の発生病理解明-遺伝要因と環境要因に着目して2013
- Author(s)
  伊東恭子
- Organizer
  第59回日本病理学会秋期特別総会
- Place of Presentation
  甲府市
- Data Source
  KAKENHI-PROJECT-22390214
[Presentation] マウス大脳皮質における L1 ノックダウンは神経細胞遊走と転写因子の発現を攪乱する2013
- Author(s)
  岸本智数、伊東恭子、伏木信次他
- Organizer
  55回日本小児神経学会総会
- Place of Presentation
  大分市
- Data Source
  KAKENHI-PROJECT-22390214
[Presentation] 胎児水頭症の分子病理学的検討-L1cam の機能分析2012
- Author(s)
  伊東恭子
- Organizer
  第9回小児病理セミナー「発育期神経疾患の臨床と病理」(招待講演).
- Place of Presentation
  大阪市
- Year and Date
  2012-09-08
- Data Source
  KAKENHI-PROJECT-22390214
[Presentation] 胎児水頭症の分子病理学的検討-L1camの機能分析-2012
- Author(s)
  伊東恭子
- Organizer
  第9回小児病理セミナー「発育期神経疾患の臨床と病理」
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-22390214
[Presentation] 環境化学物質の胎生期曝露と脳形成障害.シンポジウム「脳形成障害とオミックス」2011
- Author(s)
  伊東恭子
- Organizer
  第52回日本神経病理学会総会学術研究会
- Place of Presentation
  京都市
- Year and Date
  2011-06-03
- Data Source
  KAKENHI-PROJECT-20310036
[Presentation] ビスフェノールAがマウス大脳皮質神経細胞遊走に及ぼす影響の解明:タイムラプス蛍光イメージングを用いて2011
- Author(s)
  森脇三造、伊東恭子、中村惠子、外崎円、丹藤創、伏木信次
- Organizer
  第52回日本神経病理学会総会学術研究会
- Place of Presentation
  京都市
- Year and Date
  2011-06-03
- Data Source
  KAKENHI-PROJECT-20310036
[Presentation] ビスフェノールAの脳神経系形成過程に及ぼす影響-皮質遠心性ニューロンのゴルジ法による解析2010
- Author(s)
  中村惠子、伊東恭子、細井創、伏木信次
- Place of Presentation
  福岡市
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-20310036
[Presentation] ビスフェノールAの脳神経形成過程に及ぼす影響:マウス大脳サブプレート神経細胞における網羅的遺伝子発現解析2009
- Author(s)
  荻寛志、伊東恭子、矢追毅、伏木信次
- Organizer
  第51回日本小児神経学会総会
- Place of Presentation
  米子コンベンションセンター
- Year and Date
  2009-05-29
- Data Source
  KAKENHI-PROJECT-20310036

1. FUSHIKI Shinji (80150572)

# of Collaborated Projects: 10 results

# of Collaborated Products: 21 results
2. YAOI Takeshi (40311914)

# of Collaborated Projects: 5 results

# of Collaborated Products: 9 results
3. MATSUMOTO Akira (80181759)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 藤森亮 (50314183)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. 藤本崇宏 (10446114)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. IKEDA Hisafumi (70322493)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Tando So (80423870)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. Hoshino Atsushi (50737210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 金村米博 (80344175)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 井上匡美 (10379232)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 井上正宏 (10342990)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 下村雅律 (90433268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 常塚啓彰 (00453100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 岡田悟 (20572085)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ITOH Kyoko 伊東 恭子

Research Projects

Research Products

Co-Researchers

Molecular pathogenesis of brain malformations in de novo postzygotic mutations in the brainPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular Mechanism of Spread Through Air Space in Lung Cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of synthetic Amyloid beta receptor for Alzheimer's disease therapy

Principal Investigator

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Elucidation of molecular pathomechanisms and the search for therapeutic targets of brain malformations, by employing cerebral organoids generated from patients-derived neural stem/progenitor cellsPrincipal Investigator

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The functional significance of ASPM, responsible gene for human microcephaly, in the activation of adult neural stem cells - a new approach to brain anti-aging

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Mechanisms of brain malformations: in vitro analysis using patient-derived neural stem cells

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Pathological mechanism of abnormal brain development in thanatophoric dysplasia evaluated by using human fetal brain-derived neural stem cellsPrincipal Investigator

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Cell kinetic as well as functional analyses on microcephaly-related gene knockout micePrincipal Investigator

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Analyses on the pathogenesis of L1-associated hydrocephalus by knocking down L1 and TAG-1Principal Investigator

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Studies on the effects of prenatal exposure to bisphenol A in mouse brain, with special reference to neuronal migration and epigenetic alteratio ns

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環境中ナノ粒子の脳老化、神経変性疾患への寄与に関する探索的研究Principal Investigator

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Analyses on the pathogenesis of hydrocephalus associated with L1CAM-mutation using in utero shRNA silencingPrincipal Investigator

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Effects of endocrine disruptors on developing brain, with special reference to gene expression.

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ITOH Kyoko 伊東恭子