HIRAOKA MIKI 平岡美紀

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HIRAOKA Miki 平岡美紀

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Researcher Number	80246983
Other IDs
Affiliation (Current)	2025: 北海道医療大学, 予防医療科学センター, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 北海道医療大学, 予防医療科学センター, 准教授 2013 – 2019: 札幌医科大学, 医学部, 講師 2007 – 2008: Nippon Medical School, 医学部, 講師 2006: 日本医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 56060:Ophthalmology-related / Ophthalmology Except Principal Investigator Ophthalmology
Keywords	Principal Investigator ぶどう膜炎 / 酸化リン脂質 / 自己免疫性 / 眼内炎症 / 網膜障害 / 細胞毒性 / 房水 / マクロファージ / 細胞障害 / エンドトキシン … More / ルイスラット / ホスホリパーゼA2 / リソゾーム / リソゾームホスホリパーゼA２ / 自己免疫性ぶどう膜炎 / リン脂質分解酵素 / リン脂質 / 房水浄化機構 / 遺伝子疫学 / 遺伝疫学 / 眼科学 … More Except Principal Investigator 自己免疫 / 癌関連網膜症 / リカバリン / GRK / 視細胞 / 腫瘍随伴症候群 / Ｇ蛋白共役受容体 / 癌異所性発現 / 網膜変性 / カベオリン / recoverin / molecul;ar mimicry / TRPM1 / 自己免疫網膜症 / 腫瘍随伴神経症 / 自己免疫性網膜症 / 網膜 Less

酸化リン脂質によるぶどう膜炎での網膜細胞障害メカニズムの解明Principal Investigator
- Principal Investigator
  
  平岡美紀
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Health Sciences University of Hokkaido
The cytotoxicity of oxidized phospholipids in intraocular inflammationPrincipal Investigator
- Principal Investigator
  
  HIRAOKA Miki
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Health Sciences University of Hokkaido
  Sapporo Medical University
Study of cellular network related factors causing cancer-associated retinopathy
- Principal Investigator
  
  Ohguro Hiroshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Sapporo Medical University
Elucidation of intraocular clearance system by lipid-degrading enzymePrincipal Investigator
- Principal Investigator
  
  HIRAOKA MIKI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Sapporo Medical University
Study on molecular mechanism causing autoimmune retinopathy
- Principal Investigator
  
  Hiroshi Ohguro
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Sapporo Medical University
Genetic screening of retinopathy of prematurity and its association in the Wnt signaling pathwayPrincipal Investigator
- Principal Investigator
  
  HIRAOKA Miki
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Nippon Medical School

All 2024 2021 2020 2019 2018 2017 2016 2015 2014 2013 2008 2007 Other

All Journal Article Presentation

[Journal Article] An Increase of Oxidized Phospholipids and the Role of Macrophages in Intraocular Inflammation2020
- Author(s)
  Hiraoka Miki、Abe Akira
- Journal Title
  
  Investigative Opthalmology & Visual Science
  
  Volume: 61 Issue: 6 Pages: 23-23
- DOI
  10.1167/iovs.61.6.23
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09452
[Journal Article] Esterification of side-chain oxysterols by lysosomal phospholipase A22020
- Author(s)
  Abe Akira、Hiraoka Miki、Matsuzawa Fumiko、Aikawa Sei-ichi、Niimura Youichi
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  
  Volume: 1865 Issue: 10 Pages: 158787-158787
- DOI
  10.1016/j.bbalip.2020.158787
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09452, KAKENHI-PROJECT-19K05780
[Journal Article] Visual Function in Mice Lacking GM3 Synthase.2019
- Author(s)
  Hiraoka M, Ohkawa E, Abe A, Murata M, Go S, Inokuchi JI, Ohguro H.
- Journal Title
  
  Curr Eye Res.
  
  Volume: 27 Issue: 6 Pages: 1-7
- DOI
  10.1080/02713683.2019.1576206
- Data Source
  KAKENHI-PROJECT-16K11292
[Journal Article] A fluorometric assay for lysosomal phospholipase A2 activity using fluorescence-labeled truncated oxidized phospholipid.2018
- Author(s)
  Abe A, Hiraoka M, Shayman JA, Ohguro H.
- Journal Title
  
  Anal Biochem.
  
  Volume: 549: Pages: 164-170
- DOI
  10.1016/j.ab.2018.03.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11292
[Journal Article] Visual impairment by multiple vascular embolization with hydroxyapatite particles.2017
- Author(s)
  Marumo Y, Hiraoka M, Hashimoto M, Ohguro H.
- Journal Title
  
  Orbit
  
  Volume: 12 Issue: 3 Pages: 1-6
- DOI
  10.1080/01676830.2017.1383473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11292
[Journal Article] Preferential hydrolysis of truncated oxidized glycerophospholipids by lysosomal phospholipase A2.2017
- Author(s)
  Abe A, Hiraoka M, Ohguro H, Tesmer JJ, Shayman JA.
- Journal Title
  
  J Lipid Res.
  
  Volume: ５８ Issue: 2 Pages: 339-349
- DOI
  10.1194/jlr.m070730
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462723, KAKENHI-PROJECT-26462665, KAKENHI-PROJECT-16K11292
[Journal Article] Prolonged Ocular Inflammation in Endotoxin-Induced Uveitis in Lysosomal Phospholipase A2-Deficient Mice.2017
- Author(s)
  Sawada K, Hiraoka M, Abe A, Kelly R, Shayman JA, Ohguro H.
- Journal Title
  
  Curr Eye Res.
  
  Volume: ４２ Issue: 4 Pages: 611-616
- DOI
  10.1080/02713683.2016.1214967
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462723, KAKENHI-PROJECT-16K11292
[Journal Article] Fluctuation of lysosomal phospholipase A2 in experimental autoimmune uveitis in rats.2016
- Author(s)
  Ohkawa E, Hiraoka M, Abe A, Murata M, Ohguro H.
- Journal Title
  
  Exp Eye Res.
  
  Volume: １４９ Pages: 66-74
- DOI
  10.1016/j.exer.2016.06.017
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462723, KAKENHI-PROJECT-26462665, KAKENHI-PROJECT-16K11292
[Journal Article] Acute Retinal Necrosis Associated with Epstein-Barr Virus in a Patient Undergoing Immunosuppressive Therapy.2016
- Author(s)
  Oe C, Hiraoka M, Tanaka S, Ohguro H.
- Journal Title
  
  Case Rep Ophthalmol.
  
  Volume: １２ Issue: 1 Pages: 195-201
- DOI
  10.1159/000445372
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462723, KAKENHI-PROJECT-16K11292
[Journal Article] Effect of Antiglaucoma Medicine on Intraocular 　Pressure in DBA/2J Mice.2016
- Author(s)
  Sawada K, Hiraoka M, Ohguro H.
- Journal Title
  
  Ophthalmic Research
  
  Volume: 55 Issue: 4 Pages: 205-211
- DOI
  10.1159/000444057
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462665, KAKENHI-PROJECT-25462723, KAKENHI-PROJECT-16K11292
[Journal Article] Prolonged Ocular Inflammation in Endotoxin-Induced Uveitis in Lysosomal Phospholipase A2-Deficient Mice.2016
- Author(s)
  Sawada K, Hiraoka M, Abe A, Kelly R, Shayman JA, Ohguro H.
- Journal Title
  
  Curr Eye Res.
  
  Volume: 9 Pages: 1-6
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462665
[Journal Article] Augmentation of Lysosomal　Phospholipase A2 Activity in the Anterior Chamber in Glaucoma.2015
- Author(s)
  Hiraoka M, Abe A, Inatomi S, Sawada K, Ohguro H.
- Journal Title
  
  Current Eye Research
  
  Volume: 19 Issue: 5 Pages: 1-6
- DOI
  10.3109/02713683.2015.1056800
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462665, KAKENHI-PROJECT-25462723, KAKENHI-PROJECT-16K11292
[Journal Article] Association of cryptogenic onganizing pneumonia in bilateral anterior uveitis.2014
- Author(s)
  Fujimoto K, Hiraoka M, Inatomi S, Ohguro H
- Journal Title
  
  Case Rep Ophthalmol
  
  Volume: 5 Issue: 3 Pages: 365-372
- DOI
  10.1159/000369125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462723
[Journal Article] IkappaB kinase-β inhibitor IMD-0354 beneficially suppresses retinal vascular permeability in streptozotocin-induced diabetic mice.2014
- Author(s)
  Lennikov A, Hiraoka M, Abe A, Ohno S, Fujikawa T, Itai A, Ohguro H
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 55 Issue: 10 Pages: 6365-6373
- DOI
  10.1167/iovs.14-14671
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25462723
[Journal Article] Increase of lysosomal phospholipase A2 in aqueous humor by uveitis.2014
- Author(s)
  Hiraoka M, Abe A, Lennikov A, Kitaichi N, Ishida S, Ohguro H
- Journal Title
  
  Exp Eye Res
  
  Volume: 118. Pages: 13-19
- DOI
  10.1016/j.exer.2013.09.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462723, KAKENHI-PROJECT-25462731, KAKENHI-PROJECT-26462675
[Journal Article] Role of N-glycosylation of human lysosomal phospholipase A2 for the formation of catalytically active enzyme.2013
- Author(s)
  Hiraoka M, Okamoto K, Ohguro H, Abe A
- Journal Title
  
  J Lipid Res
  
  Volume: 54 Issue: 11 Pages: 3098-3105
- DOI
  10.1194/jlr.m041640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590393, KAKENHI-PROJECT-25462723
[Presentation] Oxidized phospholipids in vitreous fluid and preventive effect of PBN in uveitis2024
- Author(s)
  平岡美紀、Dedy Ariwansa、Durga Paudel、安彦善裕、北市伸義、南場研一、石田晋
- Organizer
  第128回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-21K09680
[Presentation] ぶどう膜炎での酸化リン脂質の代謝と細胞障害におけるマクロファージの役割2021
- Author(s)
  平岡美紀
- Organizer
  第54回日本眼炎症学会
- Data Source
  KAKENHI-PROJECT-18K09452
[Presentation] 酸化リン脂質による細胞障害と肺胞マクロファージによる抑制効果2019
- Author(s)
  平岡美紀、阿部晃
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K09452
[Presentation] 実験的自己免疫性ぶどう膜炎における過酸化リン脂質の代謝2017
- Author(s)
  平岡美紀、阿部晃、大黒浩
- Organizer
  第121回日本眼科学会総会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2017-04-06
- Data Source
  KAKENHI-PROJECT-26462665
[Presentation] リソソーム・ホスホリパーゼA2による短鎖酸化リン脂質の優先的加水分解2016
- Author(s)
  阿部晃、平岡美紀、大黒浩、Tesmer JJ、 Shayman JA.
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-28
- Data Source
  KAKENHI-PROJECT-26462665
[Presentation] 実験的自己免疫性ぶどう膜炎における過酸化リン脂質の産生2016
- Author(s)
  平岡美紀、阿部晃、大黒浩
- Organizer
  第120回日本眼科学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-04-07
- Data Source
  KAKENHI-PROJECT-26462665
[Presentation] 房水浄化機構におけるリソソームホスホリパーゼの役割2016
- Author(s)
  平岡　美紀
- Organizer
  第20回眼科分子生物学研究会
- Place of Presentation
  登別温泉第一滝本館（北海道登別市）
- Year and Date
  2016-06-25
- Data Source
  KAKENHI-PROJECT-26462665
[Presentation] 蛍光標識したラテックスビーズを用いた豚眼の線維柱帯細胞の貪食能評価2015
- Author(s)
  平岡美紀、阿部晃、大黒浩
- Organizer
  第119回日本眼科学会総会
- Place of Presentation
  さっぽろ芸術文化の館
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-26462665
[Presentation] 実験的自己免疫性ぶどう膜炎モデルラットにおけるリソソームホスホリパーゼA2 (LPLA2)の役割2015
- Author(s)
  大川映、Anton Lennikov、平岡美紀、,阿部晃、大黒浩
- Organizer
  第119回日本眼科学会総会
- Place of Presentation
  ロイトン札幌
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-26462665
[Presentation] マウスぶどう膜炎モデル（EIU）におけるリソソームホスホリパーゼA2（LPLA2）の関与2015
- Author(s)
  澤田奏子、阿部晃、平岡美紀、James A. Shayman、Robert Kelly、大黒浩
- Organizer
  第119回日本眼科学会総会
- Place of Presentation
  さっぽろ芸術文化の館
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-26462665
[Presentation] 新しい評価法を用いた前部強膜炎の病態解析の検討2015
- Author(s)
  平岡美紀、青木悠、大黒浩
- Organizer
  第69回日本臨床眼科学会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-26462665
[Presentation] Protective effect of yellow filter on light-induced retinal damage in rats.2014
- Author(s)
  Hikage F, Lennikov A, Hiraoka M, Abe A, Ohguro H
- Organizer
  World Ophthalmology Congress
- Place of Presentation
  Tokyo Forum Ｔｏｋｙｏ，　Ｊａｐａｎ
- Year and Date
  2014-04-02
- Data Source
  KAKENHI-PROJECT-25462723
[Presentation] The lysosomal phospholipase A2 activity in aqueous humor of patients with retinal diseases.2013
- Author(s)
  Sugawara A, Hiraoka M, Abe A, Ishikawa F, Ohguro H
- Organizer
  The 8th APVRS Congress & The 52nd Annual meeting of Japanese Retina and Vitreous Society
- Place of Presentation
  Nagoy, Japan
- Data Source
  KAKENHI-PROJECT-25462723
[Presentation] Connective tissue growth factor as a pathogen of proliferation of the retina in spontaneously diabetic torii rat.2013
- Author(s)
  Maeda K, Ohguro I, Hiraoka M, Abe A, Ohguro H
- Organizer
  The 8th APVRS Congress & The 52nd Annual meeting of Japanese Retina and Vitreous Society
- Place of Presentation
  Nagoy, Japan
- Data Source
  KAKENHI-PROJECT-25462723
[Presentation] 眼組織におけるCochlin分子の局在とmRNA発現2008
- Author(s)
  平岡美紀, 他
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-18591938
[Presentation] 重症未熟児網膜症における遺伝子要因の解析2007
- Author(s)
  平岡美紀, 他
- Organizer
  第30回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18591938
[Presentation] The role of lysosomal phospholipase A2 in the experimental autoimmune uveitis model of rats.
- Author(s)
  Ohkawa E, Lennikov A, Hiraoka M, Abe A, Ohguro H
- Organizer
  World Ophthalmology Congress
- Place of Presentation
  Tokyo Forum Ｔｏｋｙｏ，　Ｊａｐａｎ
- Year and Date
  2014-04-02 – 2014-04-04
- Data Source
  KAKENHI-PROJECT-25462723
[Presentation] The involvement of lysosomal phospholipase A2 in glaucoma.
- Author(s)
  Hiraoka M, Abe A, Inatomi S, Sawada K, Ohguro H
- Organizer
  World Ophthalmology Congress
- Place of Presentation
  Tokyo Forum Ｔｏｋｙｏ，　Ｊａｐａｎ
- Year and Date
  2014-04-02 – 2014-04-04
- Data Source
  KAKENHI-PROJECT-25462723
[Presentation] Involvement of lysosomal phospholipase A2 in endotoxin-induced uveitis mice.
- Author(s)
  Sawada K, Abe A, Hiraoka M, Lennikov A, Ohguro H
- Organizer
  World Ophthalmology Congress
- Place of Presentation
  Tokyo Forum Ｔｏｋｙｏ，　Ｊａｐａｎ
- Year and Date
  2014-04-02 – 2014-04-04
- Data Source
  KAKENHI-PROJECT-25462723
[Presentation] 眼内炎症におけるリソゾームホスホリパーゼA2(LPLA2)の役割
- Author(s)
  平岡　美紀
- Organizer
  第48回日本眼炎症学会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2014-07-04 – 2014-07-06
- Data Source
  KAKENHI-PROJECT-26462665

1. Hiroshi Ohguro (30203748)

# of Collaborated Projects: 4 results

# of Collaborated Products: 26 results
2. 阿部晃 (70136927)

# of Collaborated Projects: 4 results

# of Collaborated Products: 24 results
3. 東範行 (10159395)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 吉田香織 (40596160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 日景史人 (30837547)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 北市伸義 (40431366)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 南場研一 (70333599)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 岡本研

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIRAOKA MIKI 平岡 美紀

HIRAOKA Miki 平岡 美紀

Research Projects

Research Products

Co-Researchers

酸化リン脂質によるぶどう膜炎での網膜細胞障害メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The cytotoxicity of oxidized phospholipids in intraocular inflammationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of cellular network related factors causing cancer-associated retinopathy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of intraocular clearance system by lipid-degrading enzymePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on molecular mechanism causing autoimmune retinopathy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genetic screening of retinopathy of prematurity and its association in the Wnt signaling pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] An Increase of Oxidized Phospholipids and the Role of Macrophages in Intraocular Inflammation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Esterification of side-chain oxysterols by lysosomal phospholipase A22020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Visual Function in Mice Lacking GM3 Synthase.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A fluorometric assay for lysosomal phospholipase A2 activity using fluorescence-labeled truncated oxidized phospholipid.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Visual impairment by multiple vascular embolization with hydroxyapatite particles.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preferential hydrolysis of truncated oxidized glycerophospholipids by lysosomal phospholipase A2.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prolonged Ocular Inflammation in Endotoxin-Induced Uveitis in Lysosomal Phospholipase A2-Deficient Mice.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fluctuation of lysosomal phospholipase A2 in experimental autoimmune uveitis in rats.2016

Author(s)

Journal Title

DOI

HIRAOKA MIKI 平岡美紀

HIRAOKA Miki 平岡美紀

[Journal Article] Effect of Antiglaucoma Medicine on Intraocular 　Pressure in DBA/2J Mice.2016

[Journal Article] Augmentation of Lysosomal　Phospholipase A2 Activity in the Anterior Chamber in Glaucoma.2015