MIZUTA Toshihiko 水田敏彦

… Alternative Names

水田敏彦ミズタトシヒコ

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Researcher Number	80253607
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2012 – 2013: 佐賀大学, 医学部, 講師 2005 – 2006: Saga University, Faculty of Medicine, Assistant Professor, 医学部, 講師 2004: 佐賀大学, 医学部, 助手 1995: 佐賀医科大学, 医学部, 助手 1993: SAGA MEDICAL SCHOOL, Assistant professor, 医学部, 助手
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology Except Principal Investigator Public health/Health science / Gastroenterology
Keywords	Principal Investigator 5-FU / Vitamin K2 / matrix metalloproteinase / cyclin D1 / hepatoma cells / vitamin K2 / CDK inhibitor / 転写因子NF-kB / 増殖抑制効果 / Cvclin D1 … More / 細胞外マトリックス分解酵素 / Cyclin D1 / 肝癌細胞 / Hepatocellular carcinoma / Sorafenib / サイトカイン / 急性障害肝 / 肝再生 / Merosin / Laminin … More Except Principal Investigator Interferon treatment / Follow-up survey / Screening for liver disease / Prevention for liver cancer / HCV carriers / インターフェロン治療 / 追跡調査 / 肝疾患検診 / 肝癌発症予防 / C型肝炎 / Liverdysfunction / Liver fibrosis / Liver regeneration / Laminin / 肝線維化 / 細胞外マトリックス / 線維肝 / 肝障害 / 肝再生 / ラミニン Less

肝癌の分子標的治療におけるＶｉｔａｍｉｎ　Ｋ２アジュバント効果の基礎的研究Principal Investigator
- Principal Investigator
  
  水田敏彦
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Saga University
Follow-up survey of about 11,000 individuals with positive for anti-HCV identified in Saga screening system and its preventive effect for occurrence of hepatocellular carcinoma
- Principal Investigator
  
  YASUTAKE Tsutomu
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Public health/Health science
- Research Institution
  Saga University
Analysis on the mechanism of growth inhibition by vitamin K2 in hepatoma cellsPrincipal Investigator
- Principal Investigator
  
  MIZUTA Toshihiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Saga University
M鎖含有ラミニンの肝臓における発現制御と肝細胞機能に対する影響についてPrincipal Investigator
- Principal Investigator
  
  水田敏彦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  佐賀医科大学
Sigmficance of novel laminin in liver regeneration, acute injury and chronic fibrosis.
- Principal Investigator
  
  SAKAI Takahiro
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  SAGA MEDICAL SCHOOL

All 2014 2013 2012 2006 2004

All Journal Article Presentation

[Journal Article] Control of a tumor suppressor PDCD4: Degradation mechanisms of the protein in hepatocellular carcinoma cells2014
- Author(s)
  Matsuhashi S, Hamajima H, Xia JH, Zhang H, Mizuta T, Anzai K, Ozaki I
- Journal Title
  
  Cell Signal
  
  Volume: 26 Issue: 3 Pages: 603-610
- DOI
  10.1016/j.cellsig.2013.11.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590982
[Journal Article] Skin toxicities and survival in advanced hepatocellular carcinoma patients treated with sorafenib.2012
- Author(s)
  Otsuka T, Eguchi Y, Kawazoe S, Yanagita K, Ario K, Kitahara K, Kawasoe H, Kato H, Mizuta T
- Journal Title
  
  Hepatol Res
  
  Volume: 42 Issue: 9 Pages: 879-886
- DOI
  10.1111/j.1872-034x.2012.00991.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590982
[Journal Article] The role of PKC isoforms in the inhibition of NF-κB activation by vitamin K2 in human hepatocellular carcinoma cells.2012
- Author(s)
  Xia J, Matsuhashi S, Hamajima H, Iwane S, Takahashi H, Eguchi Y, Mizuta T, Fujimoto K, Kuroda S, Ozaki I.
- Journal Title
  
  J Nutr Biochem
  
  Volume: 23 Issue: 12 Pages: 1668-1675
- DOI
  10.1016/j.jnutbio.2011.11.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590982
[Journal Article] 肝癌の制御2006
- Author(s)
  水田敏彦
- Journal Title
  
  Clinician 53
  
  Pages: 218-222
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390188
[Journal Article] The effect of Menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treatment : a pilot study2006
- Author(s)
  Mizuta T
- Journal Title
  
  Cancer 106
  
  Pages: 867-872
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390188
[Journal Article] 肥満がC型肝炎の臨床経過に及ぼす影響2006
- Author(s)
  水田敏彦
- Journal Title
  
  消化器科 42(3)
  
  Pages: 271-276
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390188
[Journal Article] The influence of obesity to the clinical course of chronic hepatitis C.2006
- Author(s)
  Mizuta T
- Journal Title
  
  Shokaki-ka 42
  
  Pages: 271-276
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390188
[Journal Article] The preventive effect and its mechanism of vitamin K2 against the occurrence of hepatocellular carcinoma.2006
- Author(s)
  Mizuta T
- Journal Title
  
  Kan-Tan-Sui 52
  
  Pages: 405-411
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390188
[Journal Article] ビタミンKの抗癌作用2006
- Author(s)
  水田敏彦
- Journal Title
  
  Medical Science Digest 32 (4)
  
  Pages: 165-167
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390188
[Journal Article] ビタミンKの抗癌作用2006
- Author(s)
  水田敏彦
- Journal Title
  
  Medical Science Digest 32(4)
  
  Pages: 165-167
- Data Source
  KAKENHI-PROJECT-17390188
[Journal Article] ビタミンK2による発癌予防とその理論的背景2006
- Author(s)
  水田敏彦
- Journal Title
  
  肝胆膵 52(3)
  
  Pages: 405-411
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390188
[Journal Article] The effect of Menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treatment : a pilot study2006
- Author(s)
  Mizuta T
- Journal Title
  
  Cancer 106
  
  Pages: 867-872
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590606
[Journal Article] Anti-tumor effects of vitamin K.2006
- Author(s)
  Mizuta T
- Journal Title
  
  Medical Science Digest 32
  
  Pages: 165-167
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390188
[Journal Article] Control for liver cancer.2006
- Author(s)
  Mizuta T
- Journal Title
  
  Clinician 53
  
  Pages: 218-222
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390188
[Journal Article] Chemoprevention for liver cancer with vitamin K2004
- Author(s)
  Mizuta T
- Journal Title
  
  Naika 93
  
  Pages: 511-514
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590606
[Journal Article] がんの化学予防肝臓がん2004
- Author(s)
  水田敏彦
- Journal Title
  
  最新医学 59・11
  
  Pages: 2431-2437
- Data Source
  KAKENHI-PROJECT-16590606
[Journal Article] Chemoprevention for liver cancer2004
- Author(s)
  Mizuta T
- Journal Title
  
  Saishinigaku 59
  
  Pages: 2431-2437
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590606
[Journal Article] 肝癌のchemoprevention-ビタミンK-2004
- Author(s)
  水田敏彦
- Journal Title
  
  内科 93
  
  Pages: 511-514
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590606
[Journal Article] 特集 : がんの化学予防肝臓がん2004
- Author(s)
  水田敏彦
- Journal Title
  
  最新医学 59
  
  Pages: 2431-2437
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590606
[Journal Article] 肝癌のchemoprevention-ビタミンK-2004
- Author(s)
  水田敏彦
- Journal Title
  
  内科 93・3
  
  Pages: 511-514
- Data Source
  KAKENHI-PROJECT-16590606
[Presentation] Factors associated with long-term administration of sorafenib in patients with advanced hepatocellular carcinoma2014
- Author(s)
  Chika Tsuji, Saori Kamachi, Shunya Nakashita, Yasushi Ide, Taiga Otsuka, Iwata Ozaki, Toshihiko Mizuta
- Organizer
  APASL Liver Week 2014
- Place of Presentation
  Brisbane
- Data Source
  KAKENHI-PROJECT-24590982
[Presentation] 進行肝細胞癌に対するソラフェニブ治療におけるビタミンK２併用の効果2013
- Author(s)
  中下俊哉、小平俊一、蒲池紗央里、岩根紳治、井手康史、大塚大河、江口有一郎、川添聖治、尾崎岩太、水田敏彦
- Organizer
  第49回日本肝癌研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590982
[Presentation] 進行肝細胞癌に対する化学療法におけるビタミンK2のアジュバント効果2013
- Author(s)
  中下俊哉、蒲池紗央里、小平俊一、岩根紳治、井手康史、大塚大河、江口有一郎、川添聖治、安西慶三、尾崎岩太、水田敏彦
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590982
[Presentation] Mitogen- and phosphorylation site-specific degradation mechanisms of tumor suppressor PDCD4 in human HCC cells2013
- Author(s)
  Iwata Ozaki, Hiroshi Hamajima, Jinghe Xia, Jingyan Qi, Toshihiko Mizuta, Keizo Anzai, Sachiko Matsuhashi
- Organizer
  AASLD 64rd The Liver Meeting 2013
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-24590982
[Presentation] A scoring method for management of sorafenib after radiological progression in advanced hepatocellular carcinoma2013
- Author(s)
  Taiga Otsuka, Kimihiko Yanagita, Shunya Nakashita, Keisuke Ario, Hiroaki Kawasoe, Seiji Kawazoe, Kenji Kitahara, Hiroyuki Kato, Yuichiro Eguchi, Toshihiko Mizuta
- Organizer
  ILCA 2013
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-24590982
[Presentation] 根治的治療不応肝細胞癌に対する集学的治療戦略2013
- Author(s)
  大塚大河、川添聖治、水田敏彦
- Organizer
  第40回日本肝臓学会西部会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-24590982
[Presentation] Adjuvant effect of administration of vitamin K2 combined with sorafenib in subjects with advanced hepatocellular carcinoma2013
- Author(s)
  Shunya Nakashita, Taiga Otsuka, Chika Tsuji, Saori Kamachi, Yasushi Ide, Seiji Kawazoe, Yuichiro Eguchi, Iwata Ozaki, Toshihiko Mizuta
- Organizer
  ILCA 2013
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-24590982
[Presentation] Protein kinase C(PKC)による低酸素誘導HIF-1誘導増強効果とVitamin K２による調節2013
- Author(s)
  Jinghe Xia、尾崎岩太、Jingyan Qi、桑代卓也、岩根紳治、井手康史、江口有一郎、水田敏彦、安西慶三、松橋幸子
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590982
[Presentation] 進行肝細胞癌に対するソラフェニブ＋ビタミンK2併用療法2013
- Author(s)
  中下俊哉、小平俊一、蒲池紗央里、岩根紳治、井手康史、大塚大河、江口有一郎、川添聖治、尾崎岩太、水田敏彦
- Organizer
  第7回日本肝がん分子標的治療研究会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-24590982
[Presentation] 肝癌に対するソラフェニブ療法における予後に関する治療前の因子についての検討：佐賀県多施設共同研究2012
- Author(s)
  大塚大河、江口有一郎、川添聖治、柳田公彦、有尾啓介、北原賢二、川副広明、加藤浩之、水田敏彦
- Organizer
  第48回日本肝癌研究会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-24590982
[Presentation] Safety and efficacy of sorafenib for advanced hepatocellular carcinoma according to Child-Pugh class.2012
- Author(s)
  Saori Kamachi, Taiga Otsuka, Seiji Kawazoe, Yuichiro Eguchi, Kimihiko Yanagita, Keisuke Ario, Hiroaki Kawasoe, Toshihiko Mizuta
- Organizer
  6th ILCA Annual Conference
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-24590982
[Presentation] Continuation of sorafenib therapy beyond radiological progression in patients with advanced hepatocellular carcinoma.2012
- Author(s)
  Taiga Otsuka, Seiji Kawazoe, Yuichiro Eguchi, Kimihiko Yanagita, Keisuke Ario, Kenji Kitahara, Hiroyuki Kato, Toshihiko Mizuta
- Organizer
  6th ILCA Annual Conference
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-24590982
[Presentation] 高齢者肝癌に対するsorafenib療法の安全性および有用性2012
- Author(s)
  中下俊哉、岡田倫明、磯田広史、岩根紳治、高橋宏和、大塚大河、江口有一郎、川添聖治、尾崎岩太、水田敏彦
- Organizer
  第98回日本消化器病学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590982
[Presentation] Sorafenib versus hepatic arterial infusion chemotherapy for treatment of advanced hepatocellular carcinoma: a comparison of efficacy.2012
- Author(s)
  Shunya Nakashita, Taiga Otsuka, Seiji Kawazoe, Yuichiro Eguchi, Saori Kamachi, Hiroshi Isoda, Takumi Akiyama, Hirokazu Takahashi, Shinji Iwane, Masaru Fujimoto, Iwata Ozaki, Toshihiko Mizuta
- Organizer
  6th ILCA Annual Conference
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-24590982
[Presentation] 肝細胞癌でのNF-κB活性化におけるprotein kinase C isoformの役割2012
- Author(s)
  尾崎岩太、夏京合、松橋幸子、斉女青言、岩根紳治、高橋宏和、江口有一郎、水田敏彦
- Organizer
  第48回日本肝臓学会総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-24590982
[Presentation] 肝細胞癌に対するソラフェニブ療法とリザーバー動注療法（New FP療法）に関する比較検討2012
- Author(s)
  中下俊哉、岡田倫明、磯田広史、高橋宏和、岩根紳治、大塚大河、江口有一郎、川添聖治、尾崎岩太、水田敏彦
- Organizer
  第54回日本消化器病学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590982
[Presentation] Vitamin K2 inhibits HIF-1α activity by suppressing PKC-δ in normoxic but not hypoxic level in hepatocellular carcinoma cells.2012
- Author(s)
  Xia JingHe、尾崎岩太、松橋幸子、斉ジンヤン、岩根紳治、高橋宏和、江口有一郎、水田敏彦、安西慶三
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24590982

1. OZAKI Iwata (80214120)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
2. SAKAI Takahiro (30010367)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. YASUTAKE Tsutomu (20336126)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. EGUCHI Yuichiro (80343341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MIZUTA Toshihiko 水田 敏彦

水田 敏彦 ミズタ トシヒコ

Research Projects

Research Products

Co-Researchers

肝癌の分子標的治療におけるＶｉｔａｍｉｎ Ｋ２アジュバント効果の基礎的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Follow-up survey of about 11,000 individuals with positive for anti-HCV identified in Saga screening system and its preventive effect for occurrence of hepatocellular carcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis on the mechanism of growth inhibition by vitamin K2 in hepatoma cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

M鎖含有ラミニンの肝臓における発現制御と肝細胞機能に対する影響についてPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Sigmficance of novel laminin in liver regeneration, acute injury and chronic fibrosis.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Control of a tumor suppressor PDCD4: Degradation mechanisms of the protein in hepatocellular carcinoma cells2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Skin toxicities and survival in advanced hepatocellular carcinoma patients treated with sorafenib.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The role of PKC isoforms in the inhibition of NF-κB activation by vitamin K2 in human hepatocellular carcinoma cells.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 肝癌の制御2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] The effect of Menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treatment : a pilot study2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] 肥満がC型肝炎の臨床経過に及ぼす影響2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] The influence of obesity to the clinical course of chronic hepatitis C.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] The preventive effect and its mechanism of vitamin K2 against the occurrence of hepatocellular carcinoma.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] ビタミンKの抗癌作用2006

Author(s)

Journal Title

Description

Data Source

MIZUTA Toshihiko 水田敏彦

水田敏彦ミズタトシヒコ

肝癌の分子標的治療におけるＶｉｔａｍｉｎ　Ｋ２アジュバント効果の基礎的研究Principal Investigator

[Journal Article] がんの化学予防肝臓がん2004

[Journal Article] 特集 : がんの化学予防肝臓がん2004