UCHIUMI Takeshi 内海健

Researcher Number	80253798
Other IDs
Affiliation (Current)	2025: 九州大学, 医学研究院, 教授
Affiliation (based on the past Project Information) *help	2019 – 2025: 九州大学, 医学研究院, 教授 2015 – 2018: 九州大学, 医学研究院, 准教授 2015: 九州大学, 大学院医学研究院, 准教授 2012 – 2015: 九州大学, 医学(系)研究科(研究院), 准教授 2012: 九州大学, 大学院・医学研究院, 准教授 … More 2009 – 2011: Kyushu University, 医学研究院, 准教授 2009 – 2010: 九州大学, 大学院・医学研究院, 准教授 2007: Kyushu University, Graduated School of Medical Science, Associate professor 2006: 産業医科大学, 医学部, 講師 2000 – 2002: Dept.of Med.Biochemistry, Grad.Sch.of Med.Sciences KYUSHU UNIVERSITY Associate Professor, 大学院・医学研究院, 助手 1999: 九州大学, 大学院・医学研究科, 助手 1999: 九州大学, 大学院・医学系研究科, 助手 1998: 九州大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Basic Section 59040:Nutrition science and health science-related / General medical chemistry / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Laboratory medicine / Biological Sciences Except Principal Investigator Laboratory medicine / Basic Section 52010:General internal medicine-related / Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 52:General internal medicine and related fields … More / Pediatrics / Eating habits / Periodontology / Applied health science / Pathological medical chemistry / General medical chemistry / Biological Sciences Less
Keywords	Principal Investigator ミトコンドリア / 翻訳 / ストレス / 酸化的リン酸化 / YB-1 / YB1 / IRP2 / リボソーム / 品質管理 / UNR … More / 肝臓 / リボソーム品質管理機構 / 肝臓特異的 / サイレント変異 / 心不全 / 心不全モデルマウス / フェロトーシス / NMN / 慢性心不全 / リソソーム / 抗老化 / ストレス応答 / TFAM / 代謝物 / stress応答 / 老化 / Gene regulation / Stress / Cancer / 発現抑制 / 発現制御 / 癌 / 神経変性疾患 / ノックアウトマウス / p32 / 鉄 / RNA結合 / 転写 / MDR1 / 核移行 / p53 / 耐性遺伝子 / Yb-1 / Dubin Johnson 疾病群 / MRP3 / cMUAT / 肝炎ウイルス / グルタチオン / 大腸癌 / 抗がん剤感受性 / ABCトランスポーター / 腸肝循環 / Dubin-Johnson症候群 / C型肝炎 / 分化度 / ABC / 肝炎 / 遺伝病 / プロモーター / MRP2 … More Except Principal Investigator ミトコンドリア病 / ミトコンドリア / 老化 / ミトコンドリアDNA / メタボローム / p32 / 糖尿病 / 活性酸素 / 遺伝子診断 / TFAM / リソソーム / 心不全 / YB-1 / MRP2 / cMOAT / MRP / MDR1 / マクロファージ / 遺伝子多型 / ABCトランスポーター / 金属錯体 / 酵素法 / 核酸増幅法 / ピロリン酸 / 金属キレータ / 核酸増幅 / 高感度検出 / タンパク質凝集 / ｐ32/C1QBP / 血球分化 / 褐色脂肪細胞 / 代謝 / p32/C1QBP / 脂肪細胞分化 / 慢性心不全 / 癌 / 癌幹細胞 / 自然免疫 / 免疫応答 / 発癌 / 乾癬 / ｐ32 / NAD+ / 拡張性心筋症 / 免疫樹状細胞 / IL6 / 小児循環器学 / 臨床医学 / 次世代シーケンサー / エクソーム解析 / 先天性門脈体循環シャント / 肺高血圧 / 全エクソーム解析 / 先天性門脈体循環短絡症 / 心疾患 / p32タンパク質 / 心臓組織 / 心筋細胞 / 一炭素代謝 / 葉酸代謝 / ミトコンドリア機能異常 / Rac1 / 歯根膜 / Grp78 / 歯根膜幹細胞 / GRP78 / 再生 / 歯周組織 / アメロジェニン / タンパク質分解 / プロテアーゼ / ｐ32ノックアウトマウス / TFAM発現マウス / ミトコンドリアゲノム / ミトコンドリアプロテアーゼ / マイトファジー / 臨床検査 / プロテオーム / DNA methylation / Dubin-Johnson syndrome / efflux pump / anticancer agents / 遺伝性疾患 / 遺伝子発現調節 / 抗癌剤感受性 / 薬剤排出ポンプ / 抗がん剤 / DNAメチル化 / Dubin-Johnson症候群 / 異物排出 / rheumatoid arthritis(RA) / products(AGEs) / advanced glycation end / diabetic retinopathy / heme oxygenase-1(HO-1) / thymidine phosphory lase(TP) / macrophage infiltration / tumor angiogenesis / 血管内皮細胞 / 酸素ストレス / insituハイブリダイゼーション / ディファレンシャル・ディスプレイ法 / 血管抑制因子 / 血管促進因子 / 血管新生病 / アクチビン / ディファレンシャルディスプレイ法 / 虚血 / MMP / 糖尿病網膜症 / VEGF / 血管新生阻害剤 / GAS / TP / ヘムオキシゲナーゼ / チミジンホスホリラーゼ / 関節リウマチ / 糖尿病性網膜症 / 血管新生 / 活性酵素 / 翻訳 / リボソーム / 発現亢進 / YB1 / 遺伝子再構成YB1 / メチル化 / MDR1遺伝子 Less

オルガネラ相互作用の破綻による老化疾患の分子機序の解明と治療法の開発Principal Investigator
- Principal Investigator
  
  内海健
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kyushu University
肝臓組織特異的発現遺伝子のサイレント変異で翻訳が停止する新規分子機序Principal Investigator
- Principal Investigator
  
  内海健
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Kyushu University
Elucidation of the molecular pathogenesis of ageing diseases caused by mitochondrial dysfunction and therapeutic effects of NMN.Principal Investigator
- Principal Investigator
  
  内海健
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kyushu University
Development of high-sensitivity detection technology for nucleic acid amplification using metal and metal chelator and verification of its practicality
- Principal Investigator
  
  Hokazono Eisaku
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Kyushu University
Detection of organ-specific mitochondrial dysfunctions
- Principal Investigator
  
  Kang Dongchon
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Junshin Gakuen University
  Kyushu University
Exploration of phenomena indicative of mitochondrial dysfunction and its applications
- Principal Investigator
  
  Matsushima Yuichi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kyushu University
Research for preventive nutrition and molecular basis of mitochondrial disfunction and of compensatory folate hypermetabolic
- Principal Investigator
  
  Amamoto Rie
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  Seinan Jo Gakuin University
Identification of novel genes responsible for congenital portosystemic venous shunt
- Principal Investigator
  
  Ishii Kanako
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kyushu University
metabomic analysis of mitochondria-ralted diseases
- Principal Investigator
  
  Kang Dongchon
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kyushu University
Elucidation of mitochondrial stress response mechanism leading to anti aging and searching for diagnostic molecule, efficacyPrincipal Investigator
- Principal Investigator
  
  Uchiumi Takeshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kyushu University
Functional analysis of the proteases in mitochondrial matrix.
- Principal Investigator
  
  Matsushima Yuichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied health science
- Research Institution
  Kyushu University
Molecular basis of amelogenin-induced periodontal tissue regeneration
- Principal Investigator
  
  Fukuda Takao
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  Kyushu University
Biomarkers in blood for mitochondrial abnormality
- Principal Investigator
  
  Kang Dongchon
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kyushu University
Molecular mechanism and pathological analysis of mitochondrial chaperon protein p32Principal Investigator
- Principal Investigator
  
  UCHIUMI Takeshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyushu University
Analysis of mitochondrial functions in diseases
- Principal Investigator
  
  KANG Dongchon
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kyushu University
ミトコンドリア蛋白質の翻訳異常に伴う活性酸素の産生と細胞周期連関
- Principal Investigator
  
  康東天
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Molecular Mechanism of co-ordinately translational regulation between outer and inner mitochondriaPrincipal Investigator
- Principal Investigator
  
  UCHIUMI Takeshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyushu University
Mitochondrial DNA disease and its diagnostic system
- Principal Investigator
  
  KANG Dongchon
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kyushu University
The expression and the molecular network of CSD protein in proliferating diseasePrincipal Investigator
- Principal Investigator
  
  UCHIUMI Takeshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyushu University
  University of Occupational and Environmental Health, Japan
外界ストレスに応答するYB1遺伝子の多機能性―翻訳・転写・修復のクロストークPrincipal Investigator
- Principal Investigator
  
  内海健
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyushu University
多剤耐性の分子標的としてのABCトランスポーター遺伝子群の発見と機能
- Principal Investigator
  
  KUWANO Michihiko
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyushu University
Involvement of VEGF receptors or inflammatory cytokines in tumor angiogenesis as a cancer therapy
- Principal Investigator
  
  ONO Mayumi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  General medical chemistry
- Research Institution
  KYUSHU UNIVERSITY
ABC Transporters in Cancer and Other Diseases
- Principal Investigator
  
  KUWANO Michihiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Pathological medical chemistry
- Research Institution
  KYUSHU UNIVERSITY
ヒトcMOATの遺伝疾病と癌への関与Principal Investigator
- Principal Investigator
  
  内海健
- Project Period (FY)
  1998 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
ABCトランスポーターP糖蛋白遺伝子MDR1の発現における転写因子YB1の役割Principal Investigator
- Principal Investigator
  
  内海健
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyushu University

[Journal Article] Pyrophosphate detection method using 5-Br-PAPS to detect nucleic acid amplification - Application to LAMP method -2024
- Author(s)
  Eisaku Hokazono, Saori Fukumoto, Takeshi Uchiumi, SusumuOsawa
- Journal Title
  
  Analytical Biochemistry
  
  Volume: 684 Pages: 115371-115371
- DOI
  10.1016/j.ab.2023.115371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07340
[Journal Article] Mitochondrial haplotype mutation alleviates respiratory defect of MELAS by restoring taurine modification in tRNA with 3243A?&gt;?G mutation2023
- Author(s)
  Ueda Saori、Yagi Mikako、Tomoda Ena、Matsumoto Shinya、Ueyanagi Yasushi、Do Yura、Setoyama Daiki、Matsushima Yuichi、Nagao Asuteka、Suzuki Tsutomu、Ide Tomomi、Mori Yusuke、Oyama Noriko、Kang Dongchon、Uchiumi Takeshi
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 51 Issue: 14 Pages: 7480-7495
- DOI
  10.1093/nar/gkad591
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11678, KAKENHI-PROJECT-18H05272, KAKENHI-PROJECT-23K24794
[Journal Article] Improving lysosomal ferroptosis with NMN administration protects against heart failure2023
- Author(s)
  Yagi Mikako、Do Yura、Hirai Haruka、Miki Kenji、Toshima Takahiro、Fukahori Yukina、Setoyama Daiki、Abe Chiaki、Nabeshima Yo-Ichi、Kang Dongchon、Uchiumi Takeshi
- Journal Title
  
  Life Science Alliance
  
  Volume: 6 Issue: 12 Pages: e202302116-e202302116
- DOI
  10.26508/lsa.202302116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11678, KAKENHI-PROJECT-23K24794
[Journal Article] Induction of glioblastoma cell ferroptosis using combined treatment with chloramphenicol and 2-deoxy-d-glucose2023
- Author(s)
  Miki Kenji、Yagi Mikako、Noguchi Naoki、Do Yura、Otsuji Ryosuke、Kuga Daisuke、Kang Dongchon、Yoshimoto Koji、Uchiumi Takeshi
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 10497-10497
- DOI
  10.1038/s41598-023-37483-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11678, KAKENHI-PROJECT-23K24794
[Journal Article] Correction: Mitochondrial dysfunction and impaired growth of glioblastoma cell lines caused by antimicrobial agents inducing ferroptosis under glucose starvation2022
- Author(s)
  Miki Kenji、Yagi Mikako、Yoshimoto Koji、Kang Dongchon、Uchiumi Takeshi
- Journal Title
  
  Oncogenesis
  
  Volume: 11 Issue: 1 Pages: 64-64
- DOI
  10.1038/s41389-022-00443-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11678, KAKENHI-PROJECT-20H00530
[Journal Article] Abstract 5104: Extracellular vesicles expressing CEACAM proteins in the urine of bladder cancer patients2022
- Author(s)
  Igami Ko、Uchiumi Takeshi、Shiota Masaki、Ueda Saori、Eto Masatoshi、Kang Dongchon
- Journal Title
  
  Cancer Research
  
  Volume: 82 Issue: 12_Supplement Pages: 5104-5104
- DOI
  10.1158/1538-7445.am2022-5104
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00530
[Journal Article] Mitochondrial dysfunction-induced high hCG associated with development of fetal growth restriction and pre-eclampsia with fetal growth restriction2022
- Author(s)
  Kiyokoba Ryo、Uchiumi Takeshi、Yagi Mikako、Toshima Takahiro、Tsukahara Shigehiro、Fujita Yasuyuki、Kato Kiyoko、Kang Dongchon
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 4056-4056
- DOI
  10.1038/s41598-022-07893-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11678, KAKENHI-PROJECT-20H00530
[Journal Article] TFAM expression in brown adipocytes confers obesity resistance by secreting extracellular vesicles that promote self-activation2022
- Author(s)
  Fujii Masakazu、Setoyama Daiki、Gotoh Kazuhito、Dozono Yushi、Yagi Mikako、Ikeda Masataka、Ide Tomomi、Uchiumi Takeshi、Kang Dongchon
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 9 Pages: 104889-104889
- DOI
  10.1016/j.isci.2022.104889
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11678, KAKENHI-PROJECT-21K16090, KAKENHI-PROJECT-20H00530
[Journal Article] Stepwise Evolution of a Klebsiella pneumoniae Clone within a Host Leading to Increased Multidrug Resistance2021
- Author(s)
  Yoshino Mai、Aihara Masamune、Gotoh Yasuhiro、Akimoto Masaru、Tatsuhara Wakana、Kiyosuke Makiko、Matsushima Yuichi、Uchiumi Takeshi、Hayashi Tetsuya、Kang Dongchon
- Journal Title
  
  mSphere
  
  Volume: 6 Issue: 6 Pages: 00734-21
- DOI
  10.1128/msphere.00734-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00530, KAKENHI-PROJECT-20H03579
[Journal Article] Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss2021
- Author(s)
  Nakao Yuki、Fukuda Takao、Zhang Qunzhou、Sanui Terukazu、Shinjo Takanori、Kou Xiaoxing、Chen Chider、Liu Dawei、Watanabe Yukari、Hayashi Chikako、Yamato Hiroaki、Yotsumoto Karen、Tanaka Urara、Taketomi Takaharu、Uchiumi Takeshi、Le Anh D.、Shi Songtao、Nishimura Fusanori
- Journal Title
  
  Acta Biomaterialia
  
  Volume: 122 Pages: 306-324
- DOI
  10.1016/j.actbio.2020.12.046
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18513, KAKENHI-PROJECT-20H00530, KAKENHI-PROJECT-20H03865, KAKENHI-PROJECT-20K09958, KAKENHI-PROJECT-21K16972, KAKENHI-PROJECT-21K21089
[Journal Article] Mitochondrial Lon protease is a gatekeeper for proteins newly imported into the matrix2021
- Author(s)
  Matsushima Yuichi、Takahashi Kazuya、Yue Song、Fujiyoshi Yuki、Yoshioka Hideaki、Aihara Masamune、Setoyama Daiki、Uchiumi Takeshi、Fukuchi Satoshi、Kang Dongchon
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 974-974
- DOI
  10.1038/s42003-021-02498-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00530, KAKENHI-PROJECT-18H03180, KAKENHI-PROJECT-21K19717
[Journal Article] Genomic characteristics revealed by targeted exon sequencing of testicular germ cell tumors in Japanese men.2021
- Author(s)
  Matsumoto T, Shiota M, Uchiumi T, Ueda S, Tsukahara S, Toshima T, Matsumoto S, Noda N, Eto M, Kang D
- Journal Title
  
  Int J Urol.
  
  Volume: 28(1) Issue: 1 Pages: 40-46
- DOI
  10.1111/iju.14396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00530
[Journal Article] Clinical Impact of Heritable Thrombophilia on Neonatal-Onset Thromboembolism: A Nationwide Study in Japan2021
- Author(s)
  Egami Naoki、Ochiai Masayuki、Ichiyama Masako、Inoue Hirosuke、Sonoda Motoshi、Ishimura Masataka、Suenobu Souichi、Nishikubo Toshiya、Ishiguro Akira、Hotta Taeko、Uchiumi Takeshi、Kang Dongchon、Ohga Shouichi
- Journal Title
  
  The Journal of Pediatrics
  
  Volume: 238 Pages: 259-267.e2
- DOI
  10.1016/j.jpeds.2021.07.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00530, KAKENHI-PROJECT-18K07849
[Journal Article] Within-host evolution of a Klebsiella pneumoniae clone: selected mutations associated with the alteration of outer membrane protein expression conferred multidrug resistance.2021
- Author(s)
  Aihara M, Nishida R, Akimoto M, Gotoh Y, Kiyosuke M, Uchiumi T, Nishioka M, Matsushima Y, Hayashi T, Kang D
- Journal Title
  
  J Antimicrob Chemother
  
  Volume: 76(2) Issue: 2 Pages: 362-369
- DOI
  10.1093/jac/dkaa439
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00530, KAKENHI-PROJECT-20H03579
[Journal Article] Mitochondrial translation deficiency impairs NAD+ -mediated lysosomal acidification.2021
- Author(s)
  Yagi M, Toshima T, Amamoto R, Do Y, Hirai H, Setoyama D, Kang D, Uchiumi T.
- Journal Title
  
  EMBO J.
  
  Volume: e105268 Issue: 8 Pages: 1-17
- DOI
  10.15252/embj.2020105268
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00530, KAKENHI-PROJECT-18K15421
[Journal Article] High-throughput screen identifies 5-HT receptor as a modulator of AR and a therapeutic target for prostate cancer.2020
- Author(s)
  Itsumi M, Shiota M, Sekino Y, Ushijima M, Kashiwagi E, Takeuchi A, Inokuchi J, Kajioka S, Uchiumi T, Eto M.
- Journal Title
  
  Prostate
  
  Volume: 80 Issue: 11 Pages: 885-94
- DOI
  10.1002/pros.24022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00530
[Journal Article] Polymorphisms in androgen metabolism genes with serum testosterone levels and prognosis in androgen-deprivation therapy2020
- Author(s)
  Shiota M, Endo S, Fujimoto N, Tsukahara S, Ushijima M, Kashiwagi E, Takeuchi A, Inokuchi J, Uchiumi T, Eto M
- Journal Title
  
  Urol Oncol.
  
  Volume: 38(11) Issue: 11 Pages: 849.e11-849.e18
- DOI
  10.1016/j.urolonc.2020.06.033
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00530
[Journal Article] Genome-wide association study of genetic variations associated with treatment failure after intravesical bacillus Calmette-Guerin therapy for non-muscle invasive bladder cancer.2020
- Author(s)
  Shiota M, Fujimoto N, Yamamoto Y, Takeuchi A, Tatsugami K, Uchiumi T, Matsuyama H, Eto M.
- Journal Title
  
  Cancer Immunol Immunother.
  
  Volume: 69(7) Issue: 7 Pages: 1155-1163
- DOI
  10.1007/s00262-020-02533-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00530, KAKENHI-PROJECT-19H04488
[Journal Article] Mitochondrial Protein Synthesis Is Essential for Terminal Differentiation of CD45? TER119?Erythroid and Lymphoid Progenitors2020
- Author(s)
  Gotoh Kazuhito、Kunisaki Yuya、Mizuguchi Soichi、Setoyama Daiki、Hosokawa Kentaro、Yao Hisayuki、Nakashima Yuya、Yagi Mikako、Uchiumi Takeshi、Semba Yuichiro、Nogami Jumpei、Akashi Koichi、Arai Fumio、Kang Dongchon
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 11 Pages: 101654-101654
- DOI
  10.1016/j.isci.2020.101654
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08733, KAKENHI-PROJECT-20H00530, KAKENHI-PROJECT-18H02841, KAKENHI-PROJECT-20H03711, KAKENHI-PROJECT-18K11077, KAKENHI-PROJECT-19K22638
[Journal Article] Mitochondrial translation inhibition triggers ATF4 activation, leading to integrated stress response but not to mitochondrial unfolded protein response2020
- Author(s)
  Sasaki K, Uchiumi T, Toshima T, Yagi M, Do Y, Hirai H, Igami K, Gotoh K, Kang D.
- Journal Title
  
  Biosci Rep.
  
  Volume: 40(11) Issue: 11 Pages: 1-12
- DOI
  10.1042/bsr20201289
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00530, KAKENHI-PROJECT-18K11077, KAKENHI-PROJECT-18K15421
[Journal Article] Diagnostic challenge of the newborn patients with heritable protein C deficiency.2019
- Author(s)
  chiyama, M., Inoue, H., Ochiai, M., Ishimura, M., Shiraishi, A., Fujiyoshi, J., Yamashita, H., Sato, K., Matsumoto, S., Hotta, T., Uchiumi, T., Kang, D. and Ohga,
- Journal Title
  
  J Perinatol
  
  Volume: 39 Issue: 2 Pages: 212-219
- DOI
  10.1038/s41372-018-0262-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01550
[Journal Article] Impaired plasmalogen synthesis dysregulates liver X receptor-dependent transcription in cerebellum2019
- Author(s)
  Honsho Masanori、Dorninger Fabian、Abe Yuichi、Setoyama Daiki、Ohgi Ryohei、Uchiumi Takeshi、Kang Dongchon、Berger Johannes、Fujiki Yukio
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 166 Issue: 4 Pages: 353-361
- DOI
  10.1093/jb/mvz043
- NAID
  40022023663
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07386, KAKENHI-PROJECT-17H01550, KAKENHI-PROJECT-17H03675, KAKENHI-PROJECT-17K07337, KAKENHI-INTERNATIONAL-15K21743
[Journal Article] Mitochondrial p32/C1qbp Is a Critical Regulator of Dendritic Cell Metabolism and Maturation2018
- Author(s)
  Gotoh Kazuhito、Morisaki Takafumi、Setoyama Daiki、Sasaki Katsuhiko、Yagi Mikako、Igami Ko、Mizuguchi Soichi、Uchiumi Takeshi、Fukui Yoshinori、Kang Dongchon
- Journal Title
  
  Cell Reports
  
  Volume: 25 Issue: 7 Pages: 1800-1815
- DOI
  10.1016/j.celrep.2018.10.057
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11077, KAKENHI-PROJECT-16H02497, KAKENHI-PROJECT-17H01550, KAKENHI-PROJECT-17H03819
[Journal Article] The Association of Polymorphisms in the Gene Encoding Gonadotropin-Releasing Hormone with Serum Testosterone Level during Androgen Deprivation Therapy and Prognosis of Metastatic Prostate Cancer.2018
- Author(s)
  Shiota M, Fujimoto N, Takeuchi A, Kashiwagi E, Dejima T, Inokuchi J, Tatsugami K, Yokomizo A, Kajioka S, Uchiumi T, Eto M.
- Journal Title
  
  The Journal of Urology
  
  Volume: 199 Issue: 3 Pages: 734-740
- DOI
  10.1016/j.juro.2017.09.076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11145, KAKENHI-PROJECT-15H04764
[Journal Article] Isolated and repeated stroke-like episodes in a middle-aged man with a mitochondrial ND3 T10158C mutation: a case report2017
- Author(s)
  Mezuki Satomi、Fukuda Kenji、Matsushita Tomonaga、Fukushima Yoshihisa、Matsuo Ryu、Goto Yu-ichi、Yasukawa Takehiro、Uchiumi Takeshi、Kang Dongchon、Kitazono Takanari、Ago Tetsuro
- Journal Title
  
  BMC Neurology
  
  Volume: 17 Issue: 1
- DOI
  10.1186/s12883-017-1001-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01550
[Journal Article] Cardiomyocyte-specific loss of mitochondrial p32/C1qbp causes cardiomyopathy and activates stress responses2017
- Author(s)
  Saito Toshiro、Uchiumi Takeshi、Yagi Mikako、Amamoto Rie、Setoyama Daiki、Matsushima Yuichi、Kang Dongchon
- Journal Title
  
  Cardiovascular Research
  
  Volume: 113 Issue: 10 Pages: 1173-1185
- DOI
  10.1093/cvr/cvx095
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K00905, KAKENHI-PROJECT-17H01550, KAKENHI-PROJECT-15H03096, KAKENHI-PROJECT-15H04764
[Journal Article] Biallelic C1QBP Mutations Cause Severe Neonatal-, Childhood-, or Later-Onset Cardiomyopathy Associated with Combined Respiratory-Chain Deficiencies2017
- Author(s)
  Feichtinger RG, Olahova M, Kishita Y, Garone C, Kremer LS, Yagi M, Uchiumi T, Murayama K, Ohtake A, Rebelo-Guiomar P, Kohda M, Kang D, Mayr JA, Taylor RW, Okazaki Y, Minczuk M, Prokisch H et al
- Journal Title
  
  The American Journal of Human Genetics
  
  Volume: 101 Issue: 4 Pages: 525-538
- DOI
  10.1016/j.ajhg.2017.08.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09973, KAKENHI-PROJECT-17H01550, KAKENHI-PROJECT-15H04764
[Journal Article] Drosophila protease ClpXP specifically degrades DmLRPPRC1 controlling mitochondrial mRNA and translation2017
- Author(s)
  Matsushima Yuichi、Hirofuji Yuta、Aihara Masamune、Yue Song、Uchiumi Takeshi、Kaguni Laurie S.、Kang Dongchon
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 1-14
- DOI
  10.1038/s41598-017-08088-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01550, KAKENHI-PROJECT-15H03096, KAKENHI-PROJECT-15H04764
[Journal Article] Protein kinase C regulates Twist1 expression via NF-κB in prostate cancer2017
- Author(s)
  Shiota Masaki、Yokomizo Akira、Takeuchi Ario、Kashiwagi Eiji、Dejima Takashi、Inokuchi Junichi、Tatsugami Katsunori、Uchiumi Takeshi、Eto Masatoshi
- Journal Title
  
  Endocrine-Related Cancer
  
  Volume: 24 Issue: 4 Pages: 171-180
- DOI
  10.1530/erc-16-0384
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04764
[Journal Article] The clinical presentation and genotype of protein C deficiency with double mutations of the protein C gene.2017
- Author(s)
  Inoue H, Terachi SI, Uchiumi T, Sato T, Urata M, Ishimura M, Koga Y, Hotta T, Hara T, Kang D, Ohga S.
- Journal Title
  
  Pediatr Blood Cancer
  
  Volume: 2017 Issue: 7 Pages: e26404-e26404
- DOI
  10.1002/pbc.26404
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19623, KAKENHI-PROJECT-17H01550, KAKENHI-PROJECT-15H04764
[Journal Article] p32 is Required for Appropriate Interleukin-6 Production Upon LPS Stimulation and Protects Mice from Endotoxin Shock2017
- Author(s)
  Sasaki Katsuhiko、Gotoh Kazuhito、Miake Sho、Setoyama Daiki、Yagi Mikako、Igami Ko、Uchiumi Takeshi、Kang Dongchon
- Journal Title
  
  EBioMedicine
  
  Volume: 20 Pages: 161-172
- DOI
  10.1016/j.ebiom.2017.05.018
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01550, KAKENHI-PROJECT-15H04764, KAKENHI-PROJECT-16K19196
[Journal Article] Doxycycline induces apoptosis via ER stress selectively to cells with a cancer stem cell-like properties: importance of stem cell plasticity2017
- Author(s)
  Matsumoto Takashi、Uchiumi Takeshi、Monji Keisuke、Yagi Mikako、Setoyama Daiki、Amamoto Rie、Matsushima Yuichi、Shiota Masaki、Eto Masatoshi、Kang Dongchon
- Journal Title
  
  Oncogenesis
  
  Volume: 6 Issue: 11 Pages: 1-11
- DOI
  10.1038/s41389-017-0009-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01550, KAKENHI-PROJECT-15H03096, KAKENHI-PROJECT-15H04764
[Journal Article] Neural-specific deletion of mitochondrial p32/C1qbp leads to leukoencephalopathy due to undifferentiated oligodendrocyte and axon degeneration2017
- Author(s)
  Yagi Mikako、Uchiumi Takeshi、Sagata Noriaki、Setoyama Daiki、Amamoto Rie、Matsushima Yuichi、Kang Dongchon
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1
- DOI
  10.1038/s41598-017-15414-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K00905, KAKENHI-PROJECT-17H01550, KAKENHI-PROJECT-15H04764
[Journal Article] Mitochondrial nucleic acid binding proteins associated with diseases.2017
- Author(s)
  Uchiumi T, Kang D
- Journal Title
  
  Front Biosci
  
  Volume: 22 Pages: 168-179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01550
[Journal Article] Grp78 is critical for amelogenin-induced cell migration in a multipotent clonal human periodontal ligament cell line.2016
- Author(s)
  Toyoda K, Fukuda T, Sanui T*, Tanaka U, Yamamichi K, Atomura R, Maeda H, Tomokiyo A, Taketomi T, Uchiumi T, Nishimura F
- Journal Title
  
  Journal of Cellular Physiology
  
  Volume: 231 Issue: 2 Pages: 414-427
- DOI
  10.1002/jcp.25087
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26463136, KAKENHI-PROJECT-26463137, KAKENHI-PROJECT-15H06492, KAKENHI-PROJECT-26893196, KAKENHI-PROJECT-25293388, KAKENHI-PROJECT-26670825
[Journal Article] Serum depletion induced cancer stem cell-like phenotype due to nitric oxide synthesis in oncogenic HRas transformed cells.2016
- Author(s)
  Monji, K., Uchiumi, T., Hoshizawa, S., Yagi, M., Matsumoto, T, Y., Setoyama, D., Matsushima, Y., Gotoh, K., Amamoto, R., and Kang, D.
- Journal Title
  
  Oncotarget
  
  Volume: 7 Issue: 46 Pages: 75221-75234
- DOI
  10.18632/oncotarget.12117
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03096, KAKENHI-PROJECT-15H04764
[Journal Article] The expression of ubiquitous mitochondrial creatine kinase is downregulated as prostate cancer progression2016
- Author(s)
  Amamoto, R. Uchiumi, T. Yagi, M. Monji,K. Song, Y. Oda, Y. Shiota,M. Yokomizo, A. Naito, S. Kang, D.
- Journal Title
  
  Journal of Cancer
  
  Volume: 7 Issue: 1 Pages: 50-59
- DOI
  10.7150/jca.13207
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04764
[Journal Article] Targeting ribosomal S6 kinases/Y-box binding protein-1 signaling improves cellular sensitivity to taxane in prostate cancer2014
- Author(s)
  Shiota, M., Itsumi, M., Yokomizo, A., Takeuchi, A., Imada, K., Kashiwagi, E., Inokuchi, J., Tatsugami, K., Uchiumi, T., Naito, S.
- Journal Title
  
  The Prostate
  
  Volume: 74 Issue: 8 Pages: 829-838
- DOI
  10.1002/pros.22799
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25253041, KAKENHI-PROJECT-25462483
[Journal Article] PMA induces androgen receptor downregulation and cellular apoptosis in prostate cancer cells2014
- Author(s)
  Itsumi, M., Shiota, M., Yokomizo, A., Takeuchi, A., Kashiwagi, E., Dejima, T., Inokuchi, J., Tatsugami, K., Uchiumi, T.Naito, S.
- Journal Title
  
  J. Mol. Endocrinol.
  
  Volume: 53 Issue: 1 Pages: 31-41
- DOI
  10.1530/jme-13-0303
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25253041
[Journal Article] Twist1 and Y-box-binding protein-1 are potential prognostic factors in bladder cancer, Urol.2014
- Author(s)
  Song, Y. H., Shiota, M., Yokomizo, A., Uchiumi, T., Kiyoshima, K., Kuroiwa, K., Oda, Y., Naito, S.
- Journal Title
  
  Oncol.
  
  Volume: 32 Pages: 31-37
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25253041
[Journal Article] Inhibition of protein kinase C/Twist1 signaling augments anticancer effects of androgen deprivation and enzalutamide in prostate cancer2014
- Author(s)
  Shiota M, Yokomizo A, Takeuchi A, Imada K, Kashiwagi E, Song Y, Inokuchi J, Tatsugami K, Uchiumi T, Naito S
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 20巻 Issue: 4 Pages: 951-961
- DOI
  10.1158/1078-0432.ccr-13-1809
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24890160, KAKENHI-PROJECT-25253041
[Journal Article] Tor and the Sin3-Rpd3 complex regulate expression of the mitophagy receptor protein Atg32 in yeast.2014
- Author(s)
  Aihara M, Jin X, Kurihara Y, Yoshida Y, Matsushima Y, Oku M, Hirota Y, Saigusa T, Aoki Y, Uchiumi T, Yamamoto T, Sakai Y, Kang D, Kanki T.
- Journal Title
  
  Journal of Cell Science
  
  Volume: 127 Pages: 3184-96
- DOI
  10.1242/jcs.153254
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J04836, KAKENHI-PROJECT-24590387, KAKENHI-PROJECT-24659281, KAKENHI-PROJECT-24790556, KAKENHI-PUBLICLY-25117714, KAKENHI-PROJECT-25253041, KAKENHI-PROJECT-25461212, KAKENHI-PROJECT-25560414, KAKENHI-PUBLICLY-26111511, KAKENHI-PROJECT-26291039, KAKENHI-PROJECT-26850064
[Journal Article] EP2 signaling mediates suppressive effects of celecoxib on androgen receptor expression and cell proliferation in prostate cancer2014
- Author(s)
  Kashiwagi E, Shiota M, *Yokomizo A, Inokuchi J, Uchiumi T, Naito S.
- Journal Title
  
  Prostate Cancer P D
  
  Volume: 17 Issue: 1 Pages: 10-17
- DOI
  10.1038/pcan.2013.53
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590387, KAKENHI-PROJECT-25253041, KAKENHI-PROJECT-25462484, KAKENHI-PROJECT-221S0001
[Journal Article] Inhibition of RSK/YB-1 signaling enhances the anti-cancer effect of enzalutamide in prostate cancer,2014
- Author(s)
  Shiota, M., Yokomizo, A., Takeuchi, A., Itsumi, M., Imada, K., Kashiwagi, E., Inokuchi, J., Tatsugami, K., Uchiumi, T., Naito, S.
- Journal Title
  
  The Prostate
  
  Volume: 74 Issue: 9 Pages: 959-969
- DOI
  10.1002/pros.22813
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25253041, KAKENHI-PROJECT-25462483
[Journal Article] Casein kinase 2 is essential for mitophagy.2013
- Author(s)
  Kanki T., Kurihara Y., Jin X., Goda T., Ono Y., Aihara M., Hirota Y., Saigusa T., Aoki Y., Uchiumi T., Kang D.
- Journal Title
  
  EMBO reports
  
  Volume: 14巻 Issue: 9 Pages: 788-794
- DOI
  10.1038/embor.2013.114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J04836, KAKENHI-PROJECT-23689032, KAKENHI-PROJECT-23790371, KAKENHI-PROJECT-24659281, KAKENHI-PROJECT-24790556, KAKENHI-PUBLICLY-25117714, KAKENHI-PROJECT-25253041, KAKENHI-PROJECT-25560414
[Journal Article] Mutation and functional analysis of ABCC2/multidrug resistance protein 2 in a Japanese patient with Dubin-Johnson syndrome2013
- Author(s)
  Uchiumi T, Tanamachi H, Kuchiwaki K, Kajita M, Matsumoto S, Yagi M, Kanki T, Kang D
- Journal Title
  
  Hepatol Res
  
  Volume: 43(5) Issue: 5 Pages: 569-75
- DOI
  10.1111/j.1872-034x.2012.01103.x
- NAID
  10031183491
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689032, KAKENHI-PROJECT-24659281, KAKENHI-PUBLICLY-25117714, KAKENHI-PROJECT-25253041, KAKENHI-PROJECT-25560414
[Journal Article] Ribonucleoprotein Y-box binding protein-1 regulates mitochondrial oxidative phosphorylationprotein expression after serum stimulation through binding to OXPHOS mRNA2012
- Author(s)
  Matsumoto S, Uchiumi T, Tanamachi H, Saito T, Yagi M, Takazaki S, Kanki T, Kang D.
- Journal Title
  
  Biochem J.
  
  Volume: 12 Pages: 391-398
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] Protein instability and functional defects caused by mutations of dihydro-orotate dehydrogenase in Miller syndrome patients2012
- Author(s)
  Fang, J., Uchiumi, T., Yagi, M., Matsumoto, S., Amamoto, R., Saito, T., Takazaki, S., Kanki, T., Yamaza, H., Nonaka, K., Kang, D.
- Journal Title
  
  Bioscience reports
  
  Volume: 32 Pages: 631-639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249018
[Journal Article] Mitophagy plays an essential role in reducing mitochondrial production of reactive oxygen species and mutation of mitochondrial DNA by maintaining mitochondrial quantity and quality in yeast2012
- Author(s)
  Kurihara Y, Kanki T, Aoki Y, Hirota Y, Saigusa T, Uchiumi T, Kang D.
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Pages: 3265-72
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] Localization of mRNAs encoding human mitochondrial oxidative phosphorylation proteins2012
- Author(s)
  Matsumoto, S., Uchiumi, T., Saito, T., Yagi, M., Takazaki, S., Kanki, T., Kang, D.
- Journal Title
  
  Mitochondrion
  
  Volume: 12 Pages: 391-398
- Data Source
  KAKENHI-PROJECT-22249018
[Journal Article] p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability2012
- Author(s)
  Yagi, M., Uchiumi, T., Takazaki, S., Okuno, B., Nomura, M., Yoshida, S. I., Kanki, T., Kang, D
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 40 Pages: 9717-9737
- Data Source
  KAKENHI-PROJECT-22249018
[Journal Article] Ribonucleoprotein Y-box binding protein-1 regulates mitochondrial oxidative phosphorylation (OXPHOS) protein expression after serum stimulation through binding to OXPHOS mRNA2012
- Author(s)
  Matsumoto S, Uchiumi T, et al
- Journal Title
  
  Biochemical J
  
  Volume: 443 Issue: 2 Pages: 573-584
- DOI
  10.1042/bj20111728
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590337, KAKENHI-PROJECT-21659148, KAKENHI-PROJECT-22249018, KAKENHI-PUBLICLY-23117712, KAKENHI-PROJECT-23689032, KAKENHI-PROJECT-24659281
[Journal Article] Ribonucleoprotein Y-box-binding protein-1 regulates mitochondrial oxidative phosphorylation (OXPHOS) protein expression after serum stimulation through binding to OXPHOS mRNA2012
- Author(s)
  Matsumoto, S., Uchiumi, T., Tanamachi, H., Saito, T., Yagi, M., Takazaki, S., Kanki, T., Kang, D.
- Journal Title
  
  Biochem J.
  
  Volume: 443 Pages: 573-84
- Data Source
  KAKENHI-PROJECT-22249018
[Journal Article] oxidative stress by androgen deprivation and prevents conversion from androgen dependent to castration resistant prostate cancer2012
- Author(s)
  Shiota M, Song Y, Takeuchi A, Yokomizo A, Kashiwagi E, Kuroiwa K, Tatsugami K, Uchiumi T, Oda Y, Naito S.
- Journal Title
  
  J Urol.
  
  Volume: 187 Pages: 707-14
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] Mitophagy plays an essential role in reducing mitochondrial production of reactive oxygen species and mutation of mitochondrial DNA by maintaining mitochondrial quantity and quality in yeast2012
- Author(s)
  Kurihara, Y., Kanki, T., Aoki, Y., Hirota, Y., Saigusa, T., Uchiumi, T., Kang, D.
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Pages: 3265-72
- Data Source
  KAKENHI-PROJECT-22249018
[Journal Article] Dihydroorotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction2012
- Author(s)
  Fang, J., Uchiumi, T., Yagi, M., Matsumoto, S., Amamoto, R., Takazaki, S., Yamaza, H., Nonaka, K., Kang, D.
- Journal Title
  
  Biosci Rep.
- Data Source
  KAKENHI-PROJECT-22249018
[Journal Article] Mitophagy plays an essential role in reducing mitochondrial production of reactive oxygen species and mutation of mitochondrial DNA by maintaining mitochondrial quantity and quality in yeast2012
- Author(s)
  Kurihara Y, Kanki T, Aoki Y, Hirota Y, Saigusa T, Uchiumi T, Kang D
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Issue: 5 Pages: 3265-3272
- DOI
  10.1074/jbc.m111.280156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590337, KAKENHI-PUBLICLY-22020028, KAKENHI-PROJECT-22249018, KAKENHI-PUBLICLY-23117712, KAKENHI-PROJECT-23689032, KAKENHI-PROJECT-23790371, KAKENHI-PROJECT-24659281
[Journal Article] The role of TFAM-associated proteins in mitochondrial RNA metabolism2012
- Author(s)
  Uchiumi T, Kang D
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1820 Issue: 5 Pages: 565-570
- DOI
  10.1016/j.bbagen.2011.08.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590337, KAKENHI-PROJECT-21659148, KAKENHI-PROJECT-22249018, KAKENHI-PUBLICLY-23117712
[Journal Article] Protein instability and functional defect by mutations of dihydroorotate dehydrogenase with Miller syndrome patients2012
- Author(s)
  Fang, J., Uchiumi, T., Yagi, M., Matsumoto, S., Amamoto, R., Saito, T., Takazaki, S., Kanki, T., Yamaza, H., Nonaka, K., Kang, D.
- Journal Title
  
  Biosci Rep.
  
  Volume: 32 Pages: 631-639
- Data Source
  KAKENHI-PROJECT-22249018
[Journal Article] The role of TFAM-associated proteins in mitochondrial RNA metabolism2012
- Author(s)
  Uchiumi T, Kang D.
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1820 Pages: 565-70
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] Localization of mRNAs encoding human mitochondrial oxidative phosphorylation proteins2012
- Author(s)
  Matsumoto S, Uchiumi T, Saito T, Yagi M, Takazaki S, Kanki T, Kang D
- Journal Title
  
  Mitochondrion
  
  Volume: 12(3) Issue: 3 Pages: 391-8
- DOI
  10.1016/j.mito.2012.02.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689032, KAKENHI-PROJECT-24590387, KAKENHI-PROJECT-24659281, KAKENHI-PUBLICLY-23117712
[Journal Article] The role of TFAM-associated proteins in mitochondrial RNA metabolism,2012
- Author(s)
  Uchiumi, T., Kang, D.
- Journal Title
  
  Biochimica et biophysica acta
  
  Volume: 1820 Pages: 565-570
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249018
[Journal Article] Dihydroorotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction2012
- Author(s)
  Fang, J. Uchiumi, T. Yagi, M. Matsumoto, S. Amamoto, R. Takazaki, S. Yamaza, H. Nonaka, K. Kang, D.
- Journal Title
  
  Bioscience reports
  
  Volume: 33 Issue: 2 Pages: 217-227
- DOI
  10.1042/bsr20120097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790370, KAKENHI-PROJECT-24590387, KAKENHI-PROJECT-24659281, KAKENHI-PROJECT-25253041
[Journal Article] Antioxidant therapy alleviates oxidative stress by androgen deprivation and prevents conversion from androgen dependent to castration resistant prostate cancer2012
- Author(s)
  Shiota M, Song Y, Takeuchi A, Yokomizo A, Kashiwagi E, Kuroiwa K, Tatsugami K, Uchiumi T, Oda Y, Naito S
- Journal Title
  
  Journal Urology
  
  Volume: 187 Issue: 2 Pages: 707-714
- DOI
  10.1016/j.juro.2011.09.147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590337, KAKENHI-PROJECT-22591769
[Journal Article] p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA binding ability.2012
- Author(s)
  Yagi M, Uchiumi T, Takazaki S, Okuno B, Nomura M, Yoshida S, Kanki T, Kang D
- Journal Title
  
  Nuc Acid Res
  
  Volume: 19 Issue: 19 Pages: 9717-37
- DOI
  10.1093/nar/gks774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-22249018, KAKENHI-PROJECT-23591356, KAKENHI-PROJECT-23689032, KAKENHI-PROJECT-23790370, KAKENHI-PROJECT-24590387, KAKENHI-PROJECT-24659281, KAKENHI-PUBLICLY-23117712
[Journal Article] Protein instability and functional defects caused by mutations of dihydro-orotate dehydrogenase in Miller syndrome patients.2012
- Author(s)
  Fang J, Uchiumi T, Yagi M, Matsumoto S, Amamoto R, Saito T, Takazaki S, Kanki T, Yamaza H, Nonaka K, Kang D.
- Journal Title
  
  Biosci Rep
  
  Volume: 32 Issue: 6 Pages: 631-639
- DOI
  10.1042/bsr20120046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659967, KAKENHI-PROJECT-23689032, KAKENHI-PROJECT-23790370, KAKENHI-PROJECT-23792433, KAKENHI-PROJECT-24590387
[Journal Article] Phosphorylation of Serine 114 on Atg32 mediates mitophagy2011
- Author(s)
  Aoki, Y., Kanki, T., Hirota, Y., Kurihara, Y., Saigusa, T., Uchiumi, T., Kang, D.
- Journal Title
  
  Mol Biol Cell
  
  Volume: 22 Pages: 3206-17
- Data Source
  KAKENHI-PROJECT-22249018
[Journal Article] YB-1 bridges neural stem cells and brain tumor-initiating cells via its roles in differentiation and cell growth2011
- Author(s)
  Fotovati A, Abu-Ali S Sugita Y, Uchiumi T, et al
- Journal Title
  
  Cancer Res
  
  Volume: 71 Issue: 16 Pages: 5567-5578
- DOI
  10.1158/0008-5472.can-10-2805
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] Phosphorylation of Serine 114 on Atg32 mediates mitophagy2011
- Author(s)
  Aoki Y, Kanki T, Hirota Y, Kurihara Y, Saigusa T, Uchiumi T, Kang D.
- Journal Title
  
  Mol Biol Cell
  
  Volume: 22 Pages: 3206-17
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] Peroxiredoxin 2 in the nucleus and cytoplasm distinctly regulates androgen receptor activity in prostate cancer cells2011
- Author(s)
  Shiota M, Yokomizo A, Kashiwagi E, Takeuchi A, Fujimoto N, Uchiumi T, Naito S.
- Journal Title
  
  Free Radic Biol Med
  
  Volume: 51 Pages: 78-87
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] Mitochondrial p32/C1QBP is highly expressed in prostate cancer and is associated with shorter PSA relapse time after radical prostatectomy2011
- Author(s)
  Amamoto R, Yagi M, Song Y, Oda Y, Tsuneyoshi M, Naito S, Yokomizo A, Kuroiwa K, Tokunaga S, Kato S, Hiura H, Samori T, Kang D, Uchiumi T
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Issue: 3 Pages: 639-647
- DOI
  10.1111/j.1349-7006.2010.01828.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590337, KAKENHI-PUBLICLY-23117712
[Journal Article] Mitochondrial p32/C1QBP is highly expressed in prostate cancer and is associated with shorter PSA relapse time after radical prostatectomy.2011
- Author(s)
  Amamoto R, Yagi M, Song Y, Oda Y, Tsuneyoshi M, Naito S, Yokomizo A, Kuroiwa K, Tokunaga S, Kato S, Hiura H, Samori T, Kang D, Uchiumi T.
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Pages: 639-647
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] Mitochondrial p32/C1QBP is highly expressed in prostate cancer and is associated with shorter prostate-specific antigen relapse time after radical prostatectomy2011
- Author(s)
  Amamoto, R., Yagi, M., Song, Y., Oda, Y., Tsuneyoshi, M., Naito, S., Yokomizo, A., Kuroiwa, K., Tokunaga, S., Kato, S., Hiura, H., Samori, T., Kang, D., Uchiumi, T.
- Journal Title
  
  Cancer Sci.
  
  Volume: 102 Pages: 639-47
- NAID
  10029291485
- Data Source
  KAKENHI-PROJECT-22249018
[Journal Article] YB-1 bridges neural stem cells and brain tumor-initiating cells via its roles in differentiation and cell growth2011
- Author(s)
  Fotovati A, Abu-Ali S, Wang PS, Deleyrolle LP, Lee C, Triscott J, Chen JY, Franciosi S, Nakamura Y, Sugita Y, Uchiumi T, Kuwano M, Leavitt BR, Singh SK, Jury A, Jones C, Wakimoto H, Reynolds BA, Pallen CJ, Dunn SE.
- Journal Title
  
  Cancer Res
  
  Volume: 71 Pages: 5569-78
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] Y-box binding protein-1 promotes castration-resistant prostate cancer growth via androgen receptor expression2011
- Author(s)
  Shiota M, Takeuchi A, Song Y, Yokomizo A, Kashiwagi E, Uchiumi T, Kuroiwa K, Tatsugami K, Fujimoto N, Oda Y, Naito S.
- Journal Title
  
  Endocr Relat Cancer
  
  Volume: 18 Pages: 505-17
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] Peroxisome proliferator-activated receptor gamma coactivator-1alpha interacts with the androgen receptor (AR) and promotes prostate cancer cell growth by activating the AR.2010
- Author(s)
  Shiota, M., Yokomizo, A., Tada, Y., Inokuchi, J., Tatsugami, K., Kuroiwa, K., Uchiumi, T., Fujimoto, N., Seki, N., Naito, S.
- Journal Title
  
  Mol Endocrinol 24
  
  Pages: 114-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209019
[Journal Article] ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardation2010
- Author(s)
  Uchiumi, T., Ohgaki, K., Yagi, M., Aoki, Y., Sakai, A., Matsumoto, S., Kang, D
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 38 Pages: 5554-5568
- NAID
  120005227389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249018
[Journal Article] Castration resistance of prostate cancer cells caused by castration-induced oxidative stress through Twist1 and androgen receptor overexpression.2010
- Author(s)
  Shiota, M., Yokomizo, A., Tada, Y., Inokuchi, J., Kashiwagi, E., Masubuchi, D., Eto, M., Uchiumi, T., Naito, S.
- Journal Title
  
  Oncogene 29
  
  Pages: 237-250
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209019
[Journal Article] Tip60 promotes prostate cancer cell proliferation by translocation of androgen receptor into the nucleus2010
- Author(s)
  Shiota M, Yokomizo A, Masubuchi D, Tada Y, Inokuchi J, Eto M, Uchiumi T, Fujimoto N, Naito S.
- Journal Title
  
  Prostate
  
  Volume: 70 Pages: 540-554
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] Tip60 promotes prostate cancer cell proliferation by translocation of androgen receptor into the nucleus.2010
- Author(s)
  Shiota, M., Yokomizo, A., Masubuchi, D., Tada, Y., Inokuchi, J., Eto, M., Uchiumi, T., Fujimoto, N., Naito, S.
- Journal Title
  
  Prostate 70
  
  Pages: 540-554
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209019
[Journal Article] Sorafenib with doxorubicin augments cytotoxicity to renal cell cancer through PERK inhibition2010
- Author(s)
  Shiota M, Eto M, Yokomizo A, Tada Y, Takeuchi A, Masubuchi D, Inokuchi J, Tatsugami K, Kuroiwa K, Uchiumi T, Seki N, Naito S.
- Journal Title
  
  Int J Oncol.
  
  Volume: 36 Pages: 1521-1531
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] Foxo3a expression and acetylation regulate cancer cell growth and sensitivity to cisplatin2010
- Author(s)
  Shiota M, Yokomizo A, Kashiwagi E, Tada Y, Inokuchi J, Tatsugami K, Kuroiwa K, Uchiumi T, Seki N, Naito S.
- Journal Title
  
  Cancer Sci
  
  Volume: 101 Pages: 1177-1185
- NAID
  10026592158
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] Human heterochromatin protein 1 isoform HP1beta enhances androgen receptor activity and is implicated in prostate cancer growth2010
- Author(s)
  Shiota M, Song Y, Yokomizo A, Tada Y, Kuroiwa K, Eto M, Oda Y, Inokuchi J, Uchiumi T, Fujimoto N, Seki N, Naito S.
- Journal Title
  
  Endocr Relat Cancer
  
  Volume: 17 Pages: 455-67
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] Human heterochromatin protein 1 isoform HP1{beta} enhances androgen receptor activity and is implicated in prostate cancer growth.2010
- Author(s)
  Shiota, M., Song, Y., Yokomizo, A., Tada, Y., Kuroiwa, K., Eto, M., Oda, Y., Inokuchi, J., Uchiumi, T., Fujimoto, N., et al.
- Journal Title
  
  Endocr Relat Cancer
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209019
[Journal Article] Sensitivity of doxorubicin-resistant cells to sorafenib : possible role for inhibition of eukaryotic initiation factor-2alpha phosphorylation.2010
- Author(s)
  Shiota M, Eto M, Yokomizo A, Tada Y, Takeuchi A, Itsumi M, Tatsugami K, Uchiumi T, Naito S.
- Journal Title
  
  Int J Oncol
  
  Volume: 37 Pages: 509-517
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] Foxo3a suppression of urothelial cancer invasiveness through Twist1, Y-box-binding protein 1, and E-cadherin regulation. Clin2010
- Author(s)
  Shiota M, Song Y, Yokomizo A, Kiyoshima K, Tada Y, Uchino H, Uchiumi T, Inokuchi J, Oda Y, Kuroiwa K, Tatsugami K, Naito S.
- Journal Title
  
  Cancer Res
  
  Volume: 16 Pages: 5654-5663
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardation.2010
- Author(s)
  Uchiumi T, Ohgaki K, Yagi M, Aoki Y, Sakai A, Matsumoto S, Kang D
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 38 Pages: 5554-5568
- NAID
  120005227389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] Peroxisome proliferator-activated receptor gamma coactivatorlalpha interacts with the androgen receptor (AR) and promotes prostate cancer cell growth by activating the AR2010
- Author(s)
  Shiota M, Uchiumi T, et al
- Journal Title
  
  Mol Endocrinol 24
  
  Pages: 114-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardation2010
- Author(s)
  Uchiumi, T., Ohgaki, K., Yagi, M., Aoki, Y., Sakai, A., Matsumoto, S., Kang, D
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 38 Pages: 5554-5568
- NAID
  120005227389
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21117511
[Journal Article] Foxo3a expression and acetylation regulate cancer cell growth and sensitivity to cisplatin.2010
- Author(s)
  Shiota, M., Yokomizo, A., Kashiwagi, E., Tada, Y., Inokuchi, J., Tatsugami, K., Kuroiwa, K., Uchiumi, T., Seki, N., Naito, S.
- Journal Title
  
  Cancer Sci.
- NAID
  10026592158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209019
[Journal Article] Sorafenib with doxorubicin augments cytotoxicity to renal cell cancer through PERK inhibition.2010
- Author(s)
  Shiota, M., Eto, M., Yokomizo, A., Tada, Y., Takeuchi, A., Masubuchi, D., Inokuchi, J., Tatsugami, K., Kuroiwa, K., Uchiumi, T., et al.
- Journal Title
  
  Int J Oncol 36
  
  Pages: 1521-1531
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209019
[Journal Article] ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardation2010
- Author(s)
  Uchiumi, T., Ohgaki, K., Yagi, M., Aoki, Y., Sakai, A., Matsumoto, S., Kang, D.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 38 Pages: 5554-5568
- NAID
  120005227389
- Data Source
  KAKENHI-PROJECT-22249018
[Journal Article] Peroxisome proliferator-activated receptor gamma coactivator-1alpha interacts with the androgen receptor(AR) and promotes prostate cancer cell growth by activating the AR2010
- Author(s)
  Shiota M, Yokomizo A, Tada Y, Inokuchi J, Tatsugami K, Kuroiwa K, Uchiumi T, Fujimoto N, Seki N, Naito S.
- Journal Title
  
  Mol Endocrinol
  
  Volume: 24 Pages: 114-127
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardation.2010
- Author(s)
  Uchiumi, T., Ohgaki, K., Yagi, M., Aoki, Y., Sakai, A., Matsumoto, S., Kang, D.
- Journal Title
  
  Nucleic Acids Res.
- NAID
  120005227389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209019
[Journal Article] Role of ZNF143 in tumor growth through transcriptional regulation of DNA replication and cell-cycle-associated genes2010
- Author(s)
  Izumi H, Wakasugi T, Shimajiri S, Tanimoto A, Sasaguri Y, Kashiwagi E, Yasuniwa Y, Akiyama M, Han B, Wu Y, Uchiumi T, Arao T, Nishio K, Yamazaki R, Kohno K.
- Journal Title
  
  Cancer Sci
  
  Volume: 101 Pages: 2538-2545
- NAID
  10027834347
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardation2010
- Author(s)
  Uchiumi T, Ohgaki K, Yagi M, Aoki Y, Sakai A, Matsumoto S, Kang D.
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 38 Pages: 5554-5568
- NAID
  120005227389
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] Castration resistance of prostate cancer cells caused by castration-induced oxidative stress through Twist1 and androgen receptor overexpression2010
- Author(s)
  Shiota M, Yokomizo A, Tada Y, Inokuchi J, Kashiwagi E, Masubuchi D, Eto M, Uchiumi T, Naito S.
- Journal Title
  
  Oncogene
  
  Volume: 29 Pages: 237-250
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] P300/CBP-associated factor regulates Y-box binding protein-1 expression and promotes cancer cell growth, cancer invasion and drug resistance.2010
- Author(s)
  Shiota M, Yokomizo A, Tada Y, Uchiumi T, Inokuchi J, Tatsugami K, Kuroiwa K, Yamamoto K, Seki N, Naito S.
- Journal Title
  
  Cancer Sci
  
  Volume: 101 Pages: 1797-1806
- NAID
  10027830401
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] DNA conformation-dependent activities of human mitochondrial RNA polymerase.2009
- Author(s)
  Fukuoh A, Ohgaki K, Hatae H, Kuraoka I, Aoki Y, Uchiumi T, Jacobs HT, Kang D.
- Journal Title
  
  Genes Cells
  
  Volume: 14 Pages: 1029-1042
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] DNA conformation-dependent activities of human mitochondrial RNA polymerase2009
- Author(s)
  Fukuoh A, Uchiumi T, et al
- Journal Title
  
  Gene to cell 14
  
  Pages: 1029-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590337
[Journal Article] DNA conformation-dependent activities of human mitochondrial RNA polymerase.2009
- Author(s)
  Fukuoh, A., Ohgaki, K., Hatae, H., Kuraoka, I., Aoki, Y., Uchiumi, T., Jacobs, H.T., Kang, D.
- Journal Title
  
  Genes Cells 14
  
  Pages: 1029-1042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209019
[Journal Article] A new mechanism for primary resistance to gefitinib in lung adenocarcinoma : the role of a novel G796A mutation in exon 20 of EGFR2007
- Author(s)
  Uramoto, H., Uchiumi, T., et. al.
- Journal Title
  
  Anticancer Research 27
  
  Pages: 2297-2303
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590307
[Journal Article] A new mechanism for primary resistance to gefitinib in lung adenocarcinoma:the role of a novel G796A mutation in exon 20 of EGFR2007
- Author(s)
  Uramoto H, Uchiumi T, et. al
- Journal Title
  
  Anticancer Res2 27
  
  Pages: 2297-2303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590307
[Journal Article] A new mechanism for primary resistance to gefitinib in lung adenocarcinoma:the role of a novel G796A mutation in exon 20 of EGFR2007
- Author(s)
  Uramoto H, Uchiumi T, et. al.
- Journal Title
  
  Anticancer Res 27
  
  Pages: 2297-2303
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590307
[Journal Article] DNA topoisomerase inhibitor,etoposide,enhances GC-box-dependent prtmoter activity via Sp1 phosphorylation2007
- Author(s)
  Niina, Uchiumi T, et. al
- Journal Title
  
  Cancer Science 98
  
  Pages: 858-863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590307
[Journal Article] DNA topoisomerase inhibitor,etoposide,enhances GC-box-dependent promoter activity via Sp1 phosphorylation2007
- Author(s)
  Niina, I, Uchiumi T, et. al.
- Journal Title
  
  Cancer Science 98
  
  Pages: 858-863
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590307
[Journal Article] YB-1 is important for an early stage embryonic development : neural tube formation and cell proliferation2006
- Author(s)
  T.Uchiumi et al.
- Journal Title
  
  Journal of Biological Chemistry 81
  
  Pages: 40440-40449
- Data Source
  KAKENHI-PROJECT-18590307
[Presentation] ミトコンドリア翻訳阻害マウスの病態解析2022
- Author(s)
  八木美佳子内海健
- Organizer
  日本ミトコンドリア学会
- Data Source
  KAKENHI-PROJECT-23K24794
[Presentation] 核酸増幅過程の副産物ピロリン酸の高感度検出技術に関する検討2021
- Author(s)
  福元沙織、内海健、外園栄作
- Organizer
  第61回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K07340
[Presentation] ミトコンドリア機能低下とリソソーム機能の新規連関2019
- Author(s)
  内海健，康東天
- Organizer
  第66回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-17H01550
[Presentation] Mitochondrial translational impairment suppresses lysosomal function due to reduced NAD synthesis2019
- Author(s)
  Uchiumi T, Yagi M, Kang D
- Organizer
  The 16th ASMRM and The 19th J-mit 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01550
[Presentation] Mitochondrial Lon protease is a gatekeeper for proteins newly imported into the matrix2019
- Author(s)
  Matsushima,Y. Takahashi,K. Yue,S. Setoyama,D. Uchiumi,T. Kang,D.
- Organizer
  The 16th ASMRM and The 19th J-mit 2019
- Data Source
  KAKENHI-PROJECT-17H01550
[Presentation] 樹状細胞の成熟化におけるミトコンドリアp32の役割2019
- Author(s)
  後藤和人，内海健，康東天
- Organizer
  第64回日本臨床検査医学会九州地方会／第30回日本臨床化学会九州支部総会合同総会
- Data Source
  KAKENHI-PROJECT-17H01550
[Presentation] ミトコンドリア機能異常と葉酸代謝亢進との関連性の検討2019
- Author(s)
  天本理恵、八木美佳子、内海健
- Organizer
  第66回日本栄養改善学会
- Data Source
  KAKENHI-PROJECT-17K00905
[Presentation] ミトコンドリアシャペロン蛋白p32の変異解析と心筋特異的p32KOマウス機能解析2017
- Author(s)
  内海　健　八木美佳子　康東天
- Organizer
  第１７回日本ミトコンドリア学会
- Data Source
  KAKENHI-PROJECT-15H04764
[Presentation] Doxycycline induces apoptosis via ER stress, selectively to cells with a cancer stem cell-like properties: importance of stem cell plasticity2017
- Author(s)
  Takeshi Uchiumi, Takashi Matsumoto, Masatoshi Eto
- Organizer
  第７６回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-15H04764
[Presentation] ミトコンドリア蛋白p32の心筋、脳　特異的ノックアウトマウスにおける遺伝子発現とミトコンドリア機能解析の相違2017
- Author(s)
  八木美佳子　内海健　康東天
- Organizer
  第４０回　日本分子生物学会
- Data Source
  KAKENHI-PROJECT-15H04764
[Presentation] 前立腺がん細胞株はsphere assayにより癌幹細胞様変化をきたしドキシサイクリンの有効性2017
- Author(s)
  内海健　　康東天
- Organizer
  第６４回　日本臨床検査医学学術集会
- Data Source
  KAKENHI-PROJECT-15H04764
[Presentation] がん幹細胞は環境に応じた可塑性を示し抗生剤によるがん治療の分子機序2017
- Author(s)
  内海健　　康東天
- Organizer
  第４９回日本臨床検査自動化学会
- Data Source
  KAKENHI-PROJECT-15H04764
[Presentation] 変異型Ras依存的ガンは血清除去によりがん幹細胞様変化を示す2016
- Author(s)
  Uchiumi T
- Organizer
  日本癌分子標的治療学会
- Place of Presentation
  別府
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-15H04764
[Presentation] ミトコンドリアタンパクp32の脳特異的ノックアウトマウスの分子基盤と新規診断マーカーの探索2015
- Author(s)
  内海健、八木美佳子、康東天
- Organizer
  第55回日本臨床化学会
- Place of Presentation
  大阪
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-15H04764
[Presentation] Ras依存的発がんにおけるミトコンドリア形態と呼吸能の変化2015
- Author(s)
  内海健、門司恵介、康東天
- Organizer
  第3回がんと代謝研究会
- Place of Presentation
  金沢
- Year and Date
  2015-07-16
- Data Source
  KAKENHI-PROJECT-15H04764
[Presentation] 白質脳症を示す神経特異的C1qbp/p32ノックアウトマウスの遺伝子発現、メタボローム解析2015
- Author(s)
  内海健、八木美佳子、康東天
- Organizer
  分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04764
[Presentation] p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA binding ability2013
- Author(s)
  Uchiumi, T. and Dongchon Kang
- Organizer
  J-Mit
- Place of Presentation
  Tokyo
- Invited
- Data Source
  KAKENHI-PROJECT-24590387
[Presentation] Dihydroorotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction and Miller syndrome2012
- Author(s)
  Takeshi Uchiumi, JingXian Fang, Mikako Yagi, Rie Amamoto and Dongchon Kang
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24590387
[Presentation] ミトコンドリア翻訳調節因子p32の機能解析と細胞応答2012
- Author(s)
  内海健
- Organizer
  第85回　日本生化学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24590387
[Presentation] Ribonucleoprotein YB-1 binds to mitochondrial oxidative phosphorylation(OXPHOS) mRNA and regulate OXPHOS protein expression after serum stimulation2011
- Author(s)
  Shinya Matsumoto, Takeshi Uchiumi, Dongchon Kang
- Organizer
  第34回日本分子生物学会パシフィコ横浜
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21590337
[Presentation] ミトコンドリアRNA結合蛋白p32の機能解析2011
- Author(s)
  内海健
- Organizer
  第84回日本生化学会、京都国際会館
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21590337
[Presentation] 前立腺がんで発現亢進するミトコンドリアRNA結合蛋白p32の機能解析2011
- Author(s)
  内海健、康東天
- Organizer
  第58回日本臨床検査医学会岡山コンベンションセンター
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21590337
[Presentation] Mitochondrial p32 is highly expressed in prostate cancer and is associated with shorter PSA relapse2011
- Author(s)
  Takeshi Uchiumi, Rie Amamoto, Dongchon Kang
- Organizer
  EuroMit 8 European Meeting on Mitochondrial Pathology, Zaragoza
- Place of Presentation
  Spain
- Data Source
  KAKENHI-PROJECT-21590337
[Presentation] Embryonic lethality in mitochondrial p32 deficient, and the importance of p32 RNA binding for OXPHOS2011
- Author(s)
  Takeshi Uchiumi, Mikako Yagi, Dongchon Kang
- Organizer
  第34回日本分子生物学会パシフィコ横浜
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21590337
[Presentation] 前立腺がんで発現亢進するミトコンドリアRNA結合蛋白p32の機能解析2011
- Author(s)
  内海健、康東天
- Organizer
  第58回日本臨床検査医学会
- Place of Presentation
  岡山
- Year and Date
  2011-09-21
- Data Source
  KAKENHI-PROJECT-21590337
[Presentation] Phosphorylation of ser114 on ATG32 mediates mitophagy2011
- Author(s)
  Tomotake Kanki, Yoshimasa Aoki, Yusuke Kurihara, Tetsu Saigusa, Takeshi Uchiumi, Dongchon Kang
- Organizer
  The 8th Conference of Asian Society for Mitochondrial Research and Medicine
- Place of Presentation
  Kagoshima, Japan
- Data Source
  KAKENHI-PROJECT-22249018
[Presentation] Mitochondrial p32 is highly expressed in prostate cancer and is associated with PSA relapse time after prostatectomy2010
- Author(s)
  Takeshi Uchiumi, Rie Amamoto, Yoshinao Oda, Masasumi Tsuneyoshi, Akira Yokomizo, Seiji Naito, Yoohyun Song
- Organizer
  第69回日本癌学会大阪国際会議場
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21590337
[Presentation] ミトコンドリア蛋白p32は前立腺がんの予後マーカーになる2010
- Author(s)
  内海健、康東天
- Organizer
  第57回日本臨床検査医学会東京
- Place of Presentation
  京王プラザホテル
- Data Source
  KAKENHI-PROJECT-21590337
[Presentation] Role of ZNF143 in tumor growth through transcriptional regulation of DNA replication and cell cycle associated genes2010
- Author(s)
  Masaki Akiyama, Hiroto Izumi, Eiji Kashiwagi, Yoshihiro Yasuniwa, Bin Han, Ying Wu, Takeshi Uchiumi, Tokuzou Arao, Kazuto Nishio, Kimitoshi Kohno
- Organizer
  第69回日本癌学会大阪国際会議場
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21590337
[Presentation] ミトコンドリア蛋白p32/C1qBPは前立腺がんで高発現し予後マーカーとなりうる2010
- Author(s)
  内海健、天本理恵、康東天
- Organizer
  第83回日本分子生物学会神戸ポートアイランド
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21590337
[Presentation] The expression of ubiquitous mitochondrial creatine kinase is downregulated in prostate cancer progression2010
- Author(s)
  Takeshi Uchiumi, Rie Amamoto, Yoohyun Song, Yoshinao Oda, Masasumi Tsuneyoshi, Akira Yokomizo, Seiji Naito
- Organizer
  第70回日本癌学会名古屋国際会議場
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21590337
[Presentation] Downregulation of PDE4B activates protein kinase A and contributes to the progression of prostate cancer2010
- Author(s)
  Eiji Kashiwagi, Mashaki Shiota, Akira Yokomizo, Junichi Inokuchi, Takeshi Uchiumi, Seiji Naito
- Organizer
  第70回日本癌学会名古屋国際会議場
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21590337
[Presentation] ミトコンドリア蛋白p32は前立腺がんの予後マーカーとなりうる2010
- Author(s)
  内海健, 康東天
- Organizer
  第57回日本臨床検査医学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21590337
[Presentation] Mitochondrial p32 is highly expressed in prostate cancer and is associated with shorter PSA relapse time after prostatectomy2010
- Author(s)
  Takeshi Uchiumi, Rie Amamoto, Dongchon Kang
- Organizer
  The 7th Conference of Asian Society for Mitochondrial Research and Medicine(ASMRM) The 10th Conference of Japanese Society of Mitochondrial reaserch and Medicine(J-Mit) Fukuoka International Congress Center
- Place of Presentation
  Fukuoka
- Data Source
  KAKENHI-PROJECT-21590337
[Presentation] The role of YB-1, a binding protein partner of NPM, in hematopoiesis and acute myeloid leukemia2009
- Author(s)
  Yoko Ogasawara, Takuo Katsumoto, Takeshi Uchiumi, Kimitoshi Kohno, Issay Kitabayashi小笠原陽子、勝本拓夫、内海健,河野公俊、北林一生
- Organizer
  第68回日本癌学会パシフィコ横浜
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21590337
[Presentation] ワークショップ口演ミトコンドリアDNA維持制御因子とがん2009
- Author(s)
  内海健、康東天
- Organizer
  第49回日本臨床化学会
- Place of Presentation
  長崎大学、長崎
- Data Source
  KAKENHI-PROJECT-21590337
[Presentation] Effects of overexpression of mitochondrial transcription factor A on mitochondrial genome in Drosophila melanogaster2009
- Author(s)
  Chika Tsumita, Takeshi Uchiumi, Dongchon Kang, Etsuko T. Matsuura積田知佳、内海健、康東天、松浦悦子
- Organizer
  第32回日本分子生物学会パシフィコ横浜
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21590337
[Presentation] ミトコンドリアDNA維持制御因子とがん2009
- Author(s)
  内海健, 康東天
- Organizer
  第49回日本臨床化学会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-21590337
[Presentation] がんにおけるミトコンドリア翻訳因子ERAL1の機能2009
- Author(s)
  内海健、康東天一般口演
- Organizer
  第56回日本臨床検査医学会札幌
- Place of Presentation
  札幌コンベンションセンター
- Data Source
  KAKENHI-PROJECT-21590337
[Presentation] The knockdown of ERAL1 is involved in assembly of mitochondrial ribosome2009
- Author(s)
  内海健, 康東天
- Organizer
  第9回日本ミトコンドリア学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21590337
[Presentation] Mitochondrial translation related protein is involved in cancer cell growth and cell cycle2009
- Author(s)
  Takeshi Uchiumi
- Organizer
  第68回日本癌学会パシフィコ横浜
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21590337
[Presentation] The mitochondrial function and cell growth of mitochondrial translation related protein2009
- Author(s)
  Takeshi Uchiumi, Dongchon Kang
- Organizer
  第32回日本分子生物学会パシフィコ横浜
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21590337
[Presentation] がんにおけるミトコンドリア翻訳因子ERAL1の機能2009
- Author(s)
  内海健, 康東天
- Organizer
  第56回日本臨床検査医学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21590337
[Presentation] RNA結合蛋白YB1の癌における機能と自己抗体2007
- Author(s)
  内海健, 康東天
- Organizer
  第54回臨床検査医学会
- Place of Presentation
  大阪
- Year and Date
  2007-11-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590307
[Presentation] RNA結合蛋白YB1の癌における機能と自己抗体2001
- Author(s)
  内海健
- Organizer
  第54回臨床検査医学会
- Place of Presentation
  大阪
- Year and Date
  2001-11-22
- Data Source
  KAKENHI-PROJECT-18590307
[Presentation] Cardiomyocyte Specific Deletion of p32/C1qbp Causes Mitochondrial Cardiomyopathy
- Author(s)
  Uchiumi, T., Saito, T. Yagi, M. and Dongchon Kang
- Organizer
  EuroMit 2014
- Place of Presentation
  Tampere, Finland
- Year and Date
  2014-06-15 – 2014-06-19
- Data Source
  KAKENHI-PROJECT-24590387
[Presentation] The knockdown of ERAL1 is involved in assembly of mitochondrial ribosome
- Author(s)
  Takeshi Uchiumi, Dongchom Kang
- Organizer
  第9回日本ミトコンドリア学会
- Place of Presentation
  東京大学鉄門記念講堂、東京
- Data Source
  KAKENHI-PROJECT-21590337
[Presentation] 心筋特異的p32ノックアウトマウスは拡張型心筋症を発症するがmtUPR, autophagyを誘導し生存する
- Author(s)
  内海健、八木美佳子、康東天
- Organizer
  第１４回　日本ミトコンドリア学会
- Place of Presentation
  福岡
- Year and Date
  2014-12-03 – 2014-12-05
- Data Source
  KAKENHI-PROJECT-24590387
[Presentation] ミトコンドリア蛋白質p32のRAS依存性発ガン形質転換への関与
- Author(s)
  内海健
- Organizer
  第６１回　日本臨床検査医学会
- Place of Presentation
  福岡
- Year and Date
  2014-11-22 – 2014-11-25
- Invited
- Data Source
  KAKENHI-PROJECT-24590387

1. KANG Dongchon (80214716)

# of Collaborated Projects: 6 results

# of Collaborated Products: 34 results
2. MATSUSHIMA YUICI (20571342)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
3. TAKAZAKI Shinya (90435149)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
4. KANKI Tomotake (50398088)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
5. YAGI Mikako (70536135)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
6. 瀬戸山大樹 (30550850)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
7. WADA Morimasa (20220965)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. KUWANO Michihiko (80037431)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. KAYAMORI Yuzo (90398066)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. FUKUOH Atsushi (80363365)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
11. ONO Mayumi (80128347)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. Hokazono Eisaku (60404042)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
13. TAKAYANAGI Ryoichi (30154917)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KONO Suminori (70128015)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. IKEZAKI Kiyonobu (10145360)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. ISHIBASHI Tatsuro (30150428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. IAWAMOTO Yukihide (00213322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. YASUKAWA TAKEHIRO (90646720)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. GOTO Yu-ichi (20225668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. Fukuda Takao (80507781)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. Amamoto Rie (00352344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
22. Ishii Kanako (90400332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 西村英紀 (80208222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. 讃井彰一 (70507780)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
25. 武富孝治 (10553290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
26. 酒井康成 (10380396)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 相原正宗 (30748843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 塩津弘倫 (90625766)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. SHIOTA Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
30. OKAZAKI Yasushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. OHTAKE Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. MURAYAMA Kei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. ARAI Fumio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. HOSOKAWA Kentaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 新城尊徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 後藤和人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 江藤正俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 木下善仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 阿部雄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 石村匡崇

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 野村政壽

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 野中和明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 山座治義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

UCHIUMI Takeshi 内海 健

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オルガネラ相互作用の破綻による老化疾患の分子機序の解明と治療法の開発Principal Investigator

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肝臓組織特異的発現遺伝子のサイレント変異で翻訳が停止する新規分子機序Principal Investigator

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Elucidation of the molecular pathogenesis of ageing diseases caused by mitochondrial dysfunction and therapeutic effects of NMN.Principal Investigator

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Elucidation of mitochondrial stress response mechanism leading to anti aging and searching for diagnostic molecule, efficacyPrincipal Investigator

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Molecular mechanism and pathological analysis of mitochondrial chaperon protein p32Principal Investigator

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UCHIUMI Takeshi 内海健