TOGAWA Tadayasu 兎川忠靖

Researcher Number	80260983
Other IDs
Affiliation (based on the past Project Information) *help	2012: 明治薬科大学, 薬学部, 教授 2008: 明治薬科大学, 薬学部, 准教授
Review Section/Research Field	Except Principal Investigator Pediatrics
Keywords	Except Principal Investigator α-ガラクトシダーゼ / ファブリー病 / リソソーム病 / 分子間相互作用 / 酵素増強療法 / 基質類似体 / リソソーム酵素 / α-グルコシダーゼ / 酸性α-グルコシダーゼ / α‐ガラクトシダーゼ A … More / ポンペ病 / 酵素補充療法 / 構造生物学 / β-ヘキソミニダーゼA / β-ヘキソサミニダーゼB / β-ヘキソサミニダーゼA / ザンドホッフ病 / テイ-サックス病 / GM2ガングリオシドーシス Less

Thermodynamic and structural study on the interaction of an enzyme and a substrate analogue for development of new therapy for lysosomal diseases
- Principal Investigator
  
  SAKURABA Hitoshi
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Meiji Pharmaceutical University
Structure-based modification of lysosomal enzymes: development of new enzyme replacement therapy for lysosomal diseases
- Principal Investigator
  
  SAKURABA Hitoshi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Meiji Pharmaceutical University
  Tokyo Metropolitan Organization for Medical Research

All 2012 2011 2010 2007

All Journal Article

[Journal Article] Efficient uptakeof recombinant α-galactosidase A produced with a gene-manipulated yeast by Fabry mice kidneys.2012
- Author(s)
  Tsukimura T., Kawashima I., Togawa T., Kodama T., Suzuki T., Watanabe T., Chiba Y., Jigami Y., Fukushige T., Kanekura T., Sakuraba H.
- Journal Title
  
  Mol. Med.
  
  Volume: 18 Pages: 76-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390314
[Journal Article] Mutant α-galactosidaseA with M296I does not cause elevationof the plasmaglobotriaosylsphingosine level.2012
- Author(s)
  Mitobe S., Togawa T., Tsukimura T., Kodama T., Tanaka T., Doi K., Noiri E.,Akai Y., Saito Y., Yoshino M.,Takenaka T., Saito S., Ohno K.,Sakuraba H.
- Journal Title
  
  Mol.Genet. Metab.
  
  Volume: 107 Pages: 623-626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390314
[Journal Article] Fabry disease: Biochemical, pathological and structural studies of the α-galactosidase A with E66Q amino acid substitution.2012
- Author(s)
  Togawa T., Tsukimura T., Kodama T., Tanaka T., Kawashima I., Saito S., Ohno K., Fukushige T., Kanekura T., Satomura A., D.-H. Kang, B. H. Lee, H.-W. Yoo, Doi K., Noiri E., SakurabaH.
- Journal Title
  
  Mol. Genet. Metab.
  
  Volume: 105 Pages: 615-620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390314
[Journal Article] Lyso-GM2 ganglioside: A possible biomarker ofTay-Sachs disease and Sandhoff disease.2011
- Author(s)
  Kodama T., Togawa T., Tsukimura T., Kawashima I., Matsuoka K., Kitakaze K., Tsuji D., Itoh K., Ishida Y., Suzuki M., Suzuki T., Sakuraba H.
- Journal Title
  
  PLoS ONE.
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390314
[Journal Article] Structural basis of neuronal ceroid lipofuscinosis 1.2010
- Author(s)
  Ohno K., Saito S., Sugawara K., Suzuki T., Togawa T., Sakuraba H.
- Journal Title
  
  Brain Dev.
  
  Volume: 32 Pages: 524-530
- NAID
  10027491894
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390314
[Journal Article] Plasma globotriaosylsphingosine as a biomarker of Fabry disease2010
- Author(s)
  Togawa T, et al.
- Journal Title
  
  Mol.Genet.Metab. 97(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390314
[Journal Article] Tissue and plasma globortiaosylsphingosine could be a biomarker for assessing enzyme replacement therapy for Fabry disease.2010
- Author(s)
  Togawa T., Kawashima I., Kodama T.,Tsukimura T., Suzuki T., Fukushige T., Kanekura T., Sakuraba H.
- Journal Title
  
  Biochem. Biophys. Res.Commun.
  
  Volume: 399 Pages: 716-720
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390314
[Journal Article] Tissue and plasma globortiaosylsphingosine could be a biomarker for assessing enzyme replacement therapy for Fabry disease.2010
- Author(s)
  Togawa T, et al.
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 399 Pages: 716-720
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390314
[Journal Article] Establishment of immortalized Schwann cells from Fabry mice and their low uptake of recombinant α-galactosidase.2007
- Author(s)
  Kawashima I., Watabe K., Tajima Y., Fukushima T., Kanzaki T., Kanekura T., Sugawara K., Ohyanagi N., Suzuki T., Togawa T., Sakuraba H.
- Journal Title
  
  J. Hum. Genet. 52
  
  Pages: 1018-1025
- NAID
  10020022348
- Data Source
  KAKENHI-PROJECT-18390303

1. SAKURABA Hitoshi (60114493)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. TSUKIMURA Takahiro (50632783)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. SUZUKI Toshihiro (80322527)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. SUGAWARA Kanako (00551087)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. ITOH Kohji (00184656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 桜庭均

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results

TOGAWA Tadayasu 兎川 忠靖

Research Projects

Research Products

Co-Researchers

Thermodynamic and structural study on the interaction of an enzyme and a substrate analogue for development of new therapy for lysosomal diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structure-based modification of lysosomal enzymes: development of new enzyme replacement therapy for lysosomal diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Efficient uptakeof recombinant α-galactosidase A produced with a gene-manipulated yeast by Fabry mice kidneys.2012

Author(s)

Journal Title

Data Source

[Journal Article] Mutant α-galactosidaseA with M296I does not cause elevationof the plasmaglobotriaosylsphingosine level.2012

Author(s)

Journal Title

Data Source

[Journal Article] Fabry disease: Biochemical, pathological and structural studies of the α-galactosidase A with E66Q amino acid substitution.2012

Author(s)

Journal Title

Data Source

[Journal Article] Lyso-GM2 ganglioside: A possible biomarker ofTay-Sachs disease and Sandhoff disease.2011

Author(s)

Journal Title

Data Source

[Journal Article] Structural basis of neuronal ceroid lipofuscinosis 1.2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Plasma globotriaosylsphingosine as a biomarker of Fabry disease2010

Author(s)

Journal Title

Data Source

[Journal Article] Tissue and plasma globortiaosylsphingosine could be a biomarker for assessing enzyme replacement therapy for Fabry disease.2010

Author(s)

Journal Title

Data Source

[Journal Article] Tissue and plasma globortiaosylsphingosine could be a biomarker for assessing enzyme replacement therapy for Fabry disease.2010

Author(s)

Journal Title

Data Source

[Journal Article] Establishment of immortalized Schwann cells from Fabry mice and their low uptake of recombinant α-galactosidase.2007

Author(s)

Journal Title

NAID

Data Source

TOGAWA Tadayasu 兎川忠靖