Ishii Yukio 石井幸雄

… Alternative Names

ISHII Yukio 石井幸雄

石井幸夫イシイユキオ

石井幸雄イシイユキオ

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Researcher Number	80272194
Other IDs
External Links
Affiliation (Current)	2022: 独立行政法人国立病院機構茨城東病院(臨床研究部), 内科診療部, 内科診療部長
Affiliation (based on the past Project Information) *help	2012 – 2021: 筑波大学, 医学医療系, 教授 2009 – 2010: University of Tsukuba, 大学院・人間総合科学研究科, 准教授 2007 – 2008: University of Tsukuba, Graduats School of Comprehensive Human Sciences, Assistant Professor 2006: 筑波大学, 大学院人間総合科学研究科, 講師 2004: University of Tsukuba, Graduate School of Comprehensive Human Science, Assistant Professor, 大学院・人間総合科学研究科, 講師 … More 2002 – 2003: 筑波大学, 臨床医学系, 講師 1998: 筑波大, 臨床医学系, 講師 1996 – 1997: 筑波大学, 臨床医学系, 講師 Less
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Respiratory organ internal medicine / Basic Section 59040:Nutrition science and health science-related Except Principal Investigator Respiratory organ internal medicine / Basic Section 53030:Respiratory medicine-related
Keywords	Principal Investigator 転写因子 / 肺線維症 / Nrf2 / 酸化ストレス / マクロファージ / Th1 / Th2 / オゾン / 急性肺損傷 / TNF-α … More / MIP-2 / ラット / 急性肺傷害 / 炎症 / Ｔ－ｂｅｔ / T-bet / インターフェロンγ / interferon-gamma / IL-1β / CINC / アポトーシス / 二酸化チッ素(NO_2) / TGF-β / NF-kB / Keap1 / Th1/Th2 / 敗血症 / 急性呼吸促迫症候群 / リポ多糖体 / Toll様受容体 / インフルエンザ / レジオネラ肺炎 / 非結核性抗酸菌症 / Ｔ細胞 / 宿主応答 / 非結核性抗酸菌 / レジオネラ / ＳＱＳＴＭ１ / T細胞 / SQSTM1 / 細胞内寄生菌 / ヘルパーＴ細胞 / ナチュラルキラーT細胞 / αガラクトシルセラミド / ブレオマイシン / Natural killer T細胞 / α-galactosylceramide / マウス / NKT cells / alpha-galactosylceramide / pulmonary fibrosis / bleomysin / NrfZ / マクロフアージ / Transcription factors / Acute lung injury / Pulmonary fibrosis / Oxidative stress / Macrophages / 肺胞蛋白症 / リンパ球 / M-CSF / インターフェロン / 動物モデル / 内科 / 老化 / 肺 / アンチエイジング / 環境因子 … More Except Principal Investigator T-bet / 肺線維症 / 続発性肺胞蛋白症 / Th1 / Th17 / RORγt / 肺胞蛋白症 / 非結核性抗酸菌 / 非結核性抗酸菌症 / Th1細胞 / Th17細胞 / マクロファージ / 活性酸素 / Notchシグナリング / 上皮間葉移行 / アポトーシス / Nrf2 / 肺胞上皮細胞 / 線維芽細胞 / ROS / EMT / Notch / IL-6 / STAT3 / apoptosis / TGF-β1 / Notch経路 / ミトコンドリア / 代謝リプログラミング / 細胞分化 Less

The Role of Metabolic Reprogramming-Induced Cell Differentiation in the Development of Pulmonary Fibrosis
- Principal Investigator
  
  松野洋輔
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  University of Tsukuba
The role of oxidative stress on agingPrincipal Investigator
- Principal Investigator
  
  Ishii Yukio
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  University of Tsukuba
The role and regulatory mechanisms of ROS signaling in the pathogensis of pulmonary fibrosis
- Principal Investigator
  
  Matsuno Yosuke
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Tsukuba
Elucidation of the mechanism of T-bet-mediated induction of pulmonary alveolar proteinosisPrincipal Investigator
- Principal Investigator
  
  Ishii Yukio
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Tsukuba
Cross-talk between Th cells and inflammatory macrophages in chronic inflammatory respiratory diseases
- Principal Investigator
  
  MORISHIMA YUKO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Tsukuba
Identification of host factors which protect against the development of pulmonary inflammation induced by intracellular pathogensPrincipal Investigator
- Principal Investigator
  
  ISHII Yukio
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Tsukuba
肺胞蛋白症の新たな病態:転写因子T-betによるGM-CSF非依存性の発症機構
- Principal Investigator
  
  MORISHIMA YUKO
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Tsukuba
Role of Keap1/Nrf2 system in host defense against acute lung injury.Principal Investigator
- Principal Investigator
  
  ISHII Yukio
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Tsukuba
The protective role of Nrf2 in the development of acute lung injury and pulmonary fibrosisPrincipal Investigator
- Principal Investigator
  
  ISHII Yukio
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Tsukuba
The effects of α-galactosylceramide on the development of bleomycin-induced pulmonary fibrosisPrincipal Investigator
- Principal Investigator
  
  ISHII Yukio
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Tsukuba
混合ガス曝露による肺線維症モデルの確立と同モデルの分子生物学的解析Principal Investigator
- Principal Investigator
  
  石井幸夫 (石井幸雄)
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Tsukuba
肺損傷の可逆性と肺内浸潤好中球のアポトーシスとの関係についてPrincipal Investigator
- Principal Investigator
  
  石井幸雄
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Tsukuba

[Book] 肺MAC症におけるTh1細胞の役割. 肺MAC症診療 Up to Date2013
- Author(s)
  松山政史、石井幸雄
- Total Pages
  259
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-24591152
[Book] 別冊医学のあゆみ・最新ARDSのすべて ARDSと活性酸素2010
- Author(s)
  石井幸雄、菊池教大(石井芳樹編集)
- Total Pages
  6
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-20590911
[Journal Article] The Role of NRF2 in Mycobacterial Infection2021
- Author(s)
  Matsuyama Masashi、Nonaka Mizu、Nakajima Masayuki、Morishima Yuko、Ishii Yukio、Hizawa Nobuyuki
- Journal Title
  
  Antioxidants
  
  Volume: 10 Pages: 1861-1861
- DOI
  10.3390/antiox10121861
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03173, KAKENHI-PROJECT-21K16108
[Journal Article] Depletion of PD-1 or PD-L1 did not affect the mortality of mice infected with Mycobacterium avium2021
- Author(s)
  Nakajima Masayuki、Matsuyama Masashi、Kawaguchi Mio、Matsumura Sosuke、Kiwamoto Takumi、Matsuno Yosuke、Morishima Yuko、Yoshida Kazufumi、Sherpa Mingma Thsering、Yazaki Kai、Tanaka Ryota、Okiyama Naoko、Muratani Masafumi、Ishii Yukio、Hizawa Nobuyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Pages: 1-11
- DOI
  10.1038/s41598-021-97391-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03173, KAKENHI-PROJECT-21K16108
[Journal Article] Nrf2 Regulates Granuloma Formation and Macrophage Activation during Mycobacterium avium Infection via Mediating Nramp1 and HO-1 Expressions2021
- Author(s)
  Nakajima Masayuki、Matsuyama Masashi、Kawaguchi Mio、Kiwamoto Takumi、Matsuno Yosuke、Morishima Yuko、Yoshida Kazufumi、Sherpa Mingma、Yazaki Kai、Osawa Hajime、Muratani Masafumi、Ishii Yukio、Hizawa Nobuyuki
- Journal Title
  
  mBio
  
  Volume: 12
- DOI
  10.1128/mbio.01947-20
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03173, KAKENHI-PROJECT-18K15917
[Journal Article] ROS-Nrf2 pathway mediates the development of TGF-β1-induced epithelial-mesenchymal transition through the activation of Notch signaling2021
- Author(s)
  Yazaki Kai、Matsuno Yosuke、Yoshida Kazufumi、Sherpa Mingma、Nakajima Masayuki、Matsuyama Masashi、Kiwamoto Takumi、Morishima Yuko、Ishii Yukio、Hizawa Nobuyuki
- Journal Title
  
  European Journal of Cell Biology
  
  Volume: 100 Pages: 151181-151181
- DOI
  10.1016/j.ejcb.2021.151181
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03173, KAKENHI-PROJECT-20K08560
[Journal Article] Transcriptome genetic differences between responders and non-responders before bronchial thermoplasty.2021
- Author(s)
  Ano Satoshi、Kikuchi Norihiro、Matsuyama Masashi、Nakajima Masayuki、Kondo Yuzuru、Masuda Michiko、Osawa Hajime、Ishii Yukio、Hizawa Nobuyuki
- Journal Title
  
  J Asthma
  
  Volume: - Pages: 1-11
- DOI
  10.1080/02770903.2021.1945088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03173, KAKENHI-PROJECT-19H03663
[Journal Article] Has2 deficiency enhances OVA‐induced airway inflammation and hyperresponsiveness in mice2021
- Author(s)
  Yoshiya Tsunoda, Mingma Thsering Sherpa, Takumi Kiwamoto, Masashi Matsuyama, Hajime Osawa, Hirofumi Sakurai, Shigen Hayashi, Yosuke Matsuno, Yuko Morishima, Yukio Ishii, Nobuyuki Hizawa
- Journal Title
  
  Allergy
  
  Volume: - Pages: 2214-2218
- DOI
  10.1111/all.14715
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18J21289, KAKENHI-PROJECT-18K08139, KAKENHI-PROJECT-18H03173
[Journal Article] Transcription Factor T-bet Attenuates the Development of Elastase-induced Emphysema in Mice2019
- Author(s)
  Hayashi Shigen、Matsuno Yosuke、Tsunoda Yoshiya、Sakurai Hirofumi、Kiwamoto Takumi、Morishima Yuko、Ishii Yukio、Yoh Keigyou、Takahashi Satoru、Hizawa Nobuyuki
- Journal Title
  
  American Journal of Respiratory Cell and Molecular Biology
  
  Volume: 61 Pages: 525-536
- DOI
  10.1165/rcmb.2018-0109oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03173, KAKENHI-PROJECT-16K15454
[Journal Article] Notch Signaling Regulates Cell Density-dependent Apoptosis of NIH 3T3 through an IL-6/STAT3 Dependent Mechanism2018
- Author(s)
  Matsuno Yosuke、Kiwamoto Takumi、Morishima Yuko、Ishii Yukio、Hizawa Nobuyuki、Hogaboam Cory M.
- Journal Title
  
  European Jpurnal of Cell Biology
  
  Volume: 97 Pages: 512-522
- DOI
  10.1016/j.ejcb.2018.09.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15454, KAKENHI-PROJECT-18H03173, KAKENHI-PROJECT-16K09571
[Journal Article] Transcription Elongation Factor P-TEFb Is Involved in IL-17F Signaling in Airway Smooth Muscle Cells.2018
- Author(s)
  Nakajima Masayuki, Kawaguchi Mio, Matsuyama Masashi, Ota Kyoko, Fujita Jun, Matsukura Satoshi, Huang Shau-Ku, Morishima Yuko, Ishii Yukio, Satoh Hiroaki, Sakamoto Tohru, Hizawa Nobuyuki.
- Journal Title
  
  International Archives of Allergy and Immunology
  
  Volume: 印刷中 Pages: 83-90
- DOI
  10.1159/000488154
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15454, KAKENHI-PROJECT-15K09209, KAKENHI-PROJECT-17K09603
[Journal Article] Sulforaphane ameliorates steroid insensitivity through an Nrf2-dependent pathway in cigarette smoke-exposed asthmatic mice2018
- Author(s)
  Sakurai Hirofumi、Morishima Yuko、Ishii Yukio、Yoshida Kazufumi、Nakajima Masayuki、Tsunoda Yoshiya、Hayashi Shih-Yuan、Kiwamoto Takumi、Matsuno Yosuke、Kawaguchi Mio、Yamamoto Masayuki、Hizawa Nobuyuki
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 129 Pages: 473-485
- DOI
  10.1016/j.freeradbiomed.2018.10.400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15454, KAKENHI-PROJECT-18K19417, KAKENHI-PROJECT-18H03173, KAKENHI-PROJECT-16K09571
[Journal Article] Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice.2017
- Author(s)
  Ano S, Panariti A, Allard B, O'Sullivan M, McGovern TK, Hamamoto Y, Ishii Y, Yamamoto M, Powell WS, Martin JG.
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 102 Pages: 1-15
- DOI
  10.1016/j.freeradbiomed.2016.11.017
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-16K15454
[Journal Article] IL-17F induces IL-6 via TAK1-NFκB pathway in airway smooth muscle cells.2017
- Author(s)
  Masayuki Nakajima, Mio Kawaguchi, Kyoko Ota, Junichi Fujita, Satoshi Matsukura, Shau-Ku Huang, Yuko Morishima, Yukio Ishii, Hiroaki Satoh, Tohru Sakamoto, Nobuyuki Hizawa.
- Journal Title
  
  Immun Inflamm Dis.
  
  Volume: 3 Pages: 124-131
- DOI
  10.1002/iid3.149
- NAID
  120007129102
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09209, KAKENHI-PROJECT-17K09603, KAKENHI-PROJECT-16K15454, KAKENHI-PROJECT-15H04827
[Journal Article] Overexpression of RORγt enhances pulmonary inflammation after infection with Mycobacterium Avium.2016
- Author(s)
  Matsuyama M, Ishii Y, Sakurai H, Ano S, Morishima Y, Yoh K, Takahashi S, Ogawa K, Hizawa N
- Journal Title
  
  PLoS One
  
  Volume: 11
- DOI
  10.1371/journal.pone.0147064
- NAID
  120007127851
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15454
[Journal Article] Overexpression of RORγt Enhances Pulmonary Inflammation after Infection with Mycobacterium Avium.2016
- Author(s)
  Overexpression of RORγt Enhances Pulmonary Inflammation after Infection with Mycobacterium Avium. Matsuyama M, Ishii Y, Sakurai H, Ano S, Morishima Y, Yoh K, Takahashi S, Ogawa K, Hizawa N.
- Journal Title
  
  PLoS One
  
  Volume: 11
- NAID
  120007127851
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461178
[Journal Article] Activation of murine invariant NKT cells promotes susceptibility to candidiasis by IL-10 induced modulation of phagocyte antifungal activity.2016
- Author(s)
  Haraguchi N, Kikuchi N, Morishima Y, Matsuyama M, Sakurai H, Shibuya A, Shibuya K, Taniguchi M, Ishii Y
- Journal Title
  
  European Journal of Immunology
  
  Volume: 46 Pages: 1691-1703
- DOI
  10.1002/eji.201545987
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01365, KAKENHI-PROJECT-16H06387, KAKENHI-PROJECT-16H05169, KAKENHI-PROJECT-26461178, KAKENHI-PROJECT-16K14629, KAKENHI-PROJECT-16K15455, KAKENHI-PROJECT-16K15454
[Journal Article] 転写因子T-betによるTh1/Th17バランス制御とMAC感染症2015
- Author(s)
  松山政史、石井幸雄
- Journal Title
  
  医学のあゆみ
  
  Volume: 252 Pages: 1240-1241
- Data Source
  KAKENHI-PROJECT-24591152
[Journal Article] 喘息とCOPDにおける遺伝子改変マウスを用いたトランスレーショナルリサーチ．2015
- Author(s)
  森島祐子、石井幸雄、檜澤伸之.
- Journal Title
  
  呼吸
  
  Volume: 34 Pages: 312-324
- Data Source
  KAKENHI-PROJECT-26461178
[Journal Article] T cell-restricted T-bet overexpression induces aberrant hematopoiesis of myeloid cells and functional conversion of regional macrophages in the lung2015
- Author(s)
  Iriguchi S, Kikuchi N, Kaneko S, Noguchi E, Morishima Y, Matsuyama M, Yoh K, Takahashi S, Nakauchi H, Ishii Y
- Journal Title
  
  Blood
  
  Volume: 125 Pages: 370-382
- DOI
  10.1182/blood-2014-05-575225
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23106004, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-24390251, KAKENHI-PROJECT-24591152, KAKENHI-PUBLICLY-25114707, KAKENHI-PROJECT-26670578, KAKENHI-PROJECT-26461178
[Journal Article] SQSTM1/p62/A170 regulates the severity of Legionella pneumophila pneumonia by modulating inflammasome activity.2014
- Author(s)
  Ohtsuka S, Ishii Y, Matsuyama M, Ano S, Morishima Y, Yanagawa T, Warabi E, Hizawa N.
- Journal Title
  
  Eur J Immunol.
  
  Volume: 44 Pages: 1084-1092
- DOI
  10.1002/eji.201344091
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591152, KAKENHI-PROJECT-25220103
[Journal Article] Role of Th1/Th17 balance regulated by T-bet in a mouse model of Mycobacterium avium complex disease.2014
- Author(s)
  Matsuyama M, Ishii Y, Yageta Y, Ohtsuka S, Ano S, Matsuno Y, Morishima Y, Yoh K, Takahashi S, Ogawa K, Hogaboam CM, Hizawa N.
- Journal Title
  
  Journal of Immunology
  
  Volume: 192 Pages: 1707-1717
- DOI
  10.4049/jimmunol.1302258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591152
[Journal Article] Role of Nrf2 in host defense against influenza virus in cigarette smoke-exposed mice2011
- Author(s)
  Yageta Y, Ishii Y, Morishima Y, et al.
- Journal Title
  
  Journal of Virology 85
  
  Pages: 4679-4690
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590911
[Journal Article] Role of Nrf2 in host defense against influenza in cigarette smoke-exposed mice2011
- Author(s)
  Yageta Y, Ishii Y, et al.
- Journal Title
  
  Journal of Virology
  
  Volume: In Press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590911
[Journal Article] Aggravation of bleomycin-induced pulmonary inflammation and fibrosis in mice lacking peroxiredoxin I2011
- Author(s)
  Kikuchi N, Ishii Y, Morishima Y, et al.
- Journal Title
  
  American Journal of Respiratory Cellular and Molecular Biology (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590911
[Journal Article] Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1/Th2 balance2010
- Author(s)
  Kikuchi N, Ishii Y, et al.
- Journal Title
  
  Respiratory Research (In press)(印刷中)
- NAID
  120007138178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590911
[Journal Article] Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1/Th2 balance2010
- Author(s)
  Kikuchi N, Ishii Y, et al.
- Journal Title
  
  Respiratory Research
  
  Volume: 11
- NAID
  120007138178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590911
[Journal Article] Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1/Th2 balance2010
- Author(s)
  Kikuchi N, Ishii Y, Morishima Y, et al.
- Journal Title
  
  Respiratory Research 11
  
  Pages: 31-31
- NAID
  120007138178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590911
[Journal Article] ARDSと活性酸素2010
- Author(s)
  石井幸雄
- Journal Title
  
  最新ARDSのすべて(別冊・医学のあゆみ)
  
  Pages: 45-50
- Data Source
  KAKENHI-PROJECT-20590911
[Journal Article] Nrf2 enhances cell proliferation and resistance to anti-cancer drugs in human lung cancer2009
- Author(s)
  Homma S, Ishii Y, et al.,
- Journal Title
  
  Clinical Cancer Research (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590911
[Journal Article] 転写因子Nrf2(NF-E2 related factor-2)をめぐって2008
- Author(s)
  石井幸雄
- Journal Title
  
  Annua1 Review 呼吸器 2008
  
  Pages: 33-39
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590836
[Journal Article] 転写因子と呼吸器疾患2008
- Author(s)
  石井幸雄
- Journal Title
  
  呼吸と循環 56巻4号
  
  Pages: 393-403
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590836
[Journal Article] 呼吸器疾患と転写因子2008
- Author(s)
  石井幸雄
- Journal Title
  
  呼吸と循環 56
  
  Pages: 393-403
- NAID
  40015922704
- Data Source
  KAKENHI-PROJECT-20590911
[Journal Article] 転写因子Nrf2(NF-E2 related factor-2)をめぐって2008
- Author(s)
  石井幸雄
- Journal Title
  
  Annual Review 2008呼吸器
  
  Pages: 33-39
- Data Source
  KAKENHI-PROJECT-20590911
[Journal Article] 転写因子Nrf2(NF-E2 related factor-2)をめぐって2008
- Author(s)
  石井幸雄
- Journal Title
  
  Annual Review 呼吸器 2008
  
  Pages: 33-39
- Data Source
  KAKENHI-PROJECT-18590836
[Journal Article] Overexpression of GATA-3 protects against the development of hypersensitivity pneumoni2007
- Author(s)
  Matsuno Y, Ishii Y, et. al.
- Journal Title
  
  American Journal of Respiratory and Critical Care Medicine 176
  
  Pages: 1015-1025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590836
[Journal Article] Overexpression of the rtranscription factor GATA-3 enhances the development of pulmonary fibrosis.2006
- Author(s)
  Kimura T, Ishii Y, et al.
- Journal Title
  
  American Journal of Pathology 169
  
  Pages: 96-104
- Data Source
  KAKENHI-PROJECT-18590836
[Journal Article] ブレオマイシン肺線維症に対するαガラクトシルセラミドの治療効果2004
- Author(s)
  木村透, 石井幸雄, 他
- Journal Title
  
  臨床免疫 42(6)
  
  Pages: 704-707
- NAID
  40006574247
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570537
[Journal Article] Treatment with a-galactosylceramide attenuates the development of Bleomycin-induced pulmonary fibrosis.2004
- Author(s)
  Kimura T, Ishii Y, Morishima Y, Shibuya A, Shibuya K, Taniguchi M, et al.
- Journal Title
  
  The Journal of Immunology 172
  
  Pages: 5782-5789
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570537
[Journal Article] Treatment with α-galactosylceramide attenuates the development of bleomcin-induced pulmonary fibrosis.2004
- Author(s)
  Kimura T, Ishii Y, et al.
- Journal Title
  
  The Journal of Immunology 172
  
  Pages: 5782-5789
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570537
[Journal Article] Inhibitory effects of a-galactosylceramide on bleomycin-induced pulmonary fibrosis in mice.2004
- Author(s)
  Kimura T, Ishii Y, Morishima Y, Sekizawa K.
- Journal Title
  
  Clinical Immunology (Rinsyo Men-eki) 42(6)
  
  Pages: 704-707
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570537
[Presentation] Elovl6欠損による肺組織脂肪酸組成変化がもたらす喘息重症化の分子病態の解明2021
- Author(s)
  吉田和史, 森島祐子, 櫻井啓文, 大澤翔, 矢崎海, 中嶋真之, 松山政史, 際本拓未, 松野洋輔, 石井幸雄, 檜澤伸之
- Organizer
  第61回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18H03173
[Presentation] RNA-seqによる遺伝子発現解析に基づいた，RNA-seqによる遺伝子発現解析に基づいたMycobacterium avium感染後の宿主免疫応答の評価2021
- Author(s)
  松村聡介，中嶋真之，松山政史，酒井千緒，矢崎　海，吉田和史，際本拓未，松野洋輔，森島祐子，石井幸雄，檜澤伸之
- Organizer
  第61回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18H03173
[Presentation] The Role of Mitochondria-Dependent Metabolic Reprogramming in the Pathogenesis of Pulmonary Fibrosis2021
- Author(s)
  矢崎海，松野洋輔，蔵本健矢，Sherpa Mingma，吉田和史，松山政史，際本拓未，森島祐子，石井幸雄，檜澤伸之
- Organizer
  The 25th Congress of the Asian Pacific Society of Respirology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08560
[Presentation] 老化は如何に呼吸器疾患に関与するか－COPDや感染症における検証－2021
- Author(s)
  石井幸雄
- Organizer
  第52回結核・非定型抗酸菌症治療研究会
- Data Source
  KAKENHI-PROJECT-18H03173
[Presentation] Role of Nrf2 in pulmonary MAC infection using mice model.2020
- Author(s)
  Nakajima M, Matsuyama M, Kawaguchi M, Sherpa M, Osawa H, Yoshida K, Yazaki K, Kiwamoto T, Matsuno Y, Morishima Y, Ishii Y, Hizawa N
- Organizer
  2020 International Conference of American Thoracic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03173
[Presentation] Hyaluronan synthase 2 attenuates airway inflammation and remodeling in an ovalbumin-induced chronic mouse model of asthma.2020
- Author(s)
  Sherpa M, Kiwamoto T, Tsunoda Y, Osawa H, Yoshida K, Nakajima M, Matsuyama M, Matsuno Y, Morishima Y, Ishii Y, Hizawa N.
- Organizer
  2020 International Conference of American Thoracic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03173
[Presentation] マウスを用いた肺MAC感染モデルにおけるNrf2の役割2020
- Author(s)
  中嶋真之, 松山政史, 川口未央, Mingma Sherpa, 大澤翔, 矢崎海, 吉田和史, 塩澤利博, 中澤健介, 小川良子, 際本拓未, 松野洋輔, 森島祐子, 石井幸雄, 坂本透, 檜澤伸之
- Organizer
  第60回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18H03173
[Presentation] Deletion of Elovl6 alters fatty acid composition in lung tissue and enhances allergic airway inflammation.2019
- Author(s)
  Yoshida K, Morishima Y, Sakurai H, Sherpa M, Tsunoda Y, Nakajima M, Matsuyama M, Kiwamoto T, Matsuno Y, Ishii Y, Hizawa N.
- Organizer
  2019 International Conference of American Thoracic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03173
[Presentation] Hyaluronan synthase 2 (HAS2) mediates airway inflammation and remodeling in chronic ovalbumin model of asthma.2019
- Author(s)
  Sherpa M, Kiwamoto T, Tsunoda Y, Yoshida K, Osawa H, Nakajima M, Matsuyama M, Matsuno Y, Morishima Y, Ishii Y, Hizawa N.
- Organizer
  2019 International Conference of American Thoracic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03173
[Presentation] Hyaluronan synthase 2 (HAS2) mediates airway inflammation and remodeling in chronic ovalbumin model of asthma.2019
- Author(s)
  Sherpa M, Kiwamoto T, Tsunoda Y, Yoshida K, Osawa H, Nakajima M, Matsuyama M, Matsuno Y, Morishima Y, Ishii Y, Hizawa N.
- Organizer
  2019 International Conference of American Thoracic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15454
[Presentation] Role of PD-1 pathway in pulmonary MAC infection using mice model.2019
- Author(s)
  Nakajima M, Matsuyama M, Kawaguchi M, Sherpa M, Yoshida K, Kiwamoto T, Matsuno Y, Morishima Y, Ishii Y, Hizawa N.
- Organizer
  2019 International Conference of American Thoracic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15454
[Presentation] Deletion of Elovl6 alters fatty acid composition in lung tissue and enhances allergic airway inflammation.2019
- Author(s)
  Yoshida K, Morishima Y, Sakurai H, Sherpa M, Tsunoda Y, Nakajima M, Matsuyama M, Kiwamoto T, Matsuno Y, Ishii Y, Hizawa N.
- Organizer
  2019 International Conference of American Thoracic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15454
[Presentation] Role of PD-1 pathway in pulmonary MAC infection using mice model.2019
- Author(s)
  Nakajima M, Matsuyama M, Kawaguchi M, Sherpa M, Yoshida K, Kiwamoto T, Matsuno Y, Morishima Y, Ishii Y, Hizawa N.
- Organizer
  2019 International Conference of American Thoracic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03173
[Presentation] ROS-Nrf2 Pathway Mediates the Development of TGF-b1-Induced Epithelial-Mesenchymal Transition Through the Interaction with Notch Signaling2018
- Author(s)
  Yosuke Matsuno, Masashi Matsuyama, Takumi Kiwamoto, Yuko Morishima, Yukio Ishii, Nobuyuki Hizawa
- Organizer
  American Thoracic Society Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09571
[Presentation] ROS-Nrf2 pathway mediates the development of TGF-b1-induced epithelial-mesenchymal transition through the interaction with notch signaling.2018
- Author(s)
  Matsuno Y, Matsuyama M, Kiwamoto T, Morishima Y, Ishii Y, Hizawa N
- Organizer
  2018 International Conference of American Thoracic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15454
[Presentation] ROS-Nrf2 pathway mediates the development of TGF-b1-induced epithelial-mesenchymal transition through the interaction with notch signaling2018
- Author(s)
  Matsuno Y, Matsuyama M, Kiwamoto T, Morishima Y, Ishii Y, Hizawa N
- Organizer
  International Conference of American Thoracic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03173
[Presentation] The role of elongation of very long chain fatty acids family member 6 in allergic airway inflammation.2018
- Author(s)
  Yoshida K, Morishima Y, Sakurai H, Tsunoda Y, Nakajima M, Matsuyama M, Kiwamoto T, Matsuno Y, Ishii Y, Hizawa N
- Organizer
  2018 International Conference of American Thoracic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15454
[Presentation] Hyaluronan synthase 2 dysfunction induce severe eosinophilic airway inflammation via inflammatory cytokines and chemokines.2018
- Author(s)
  Kiwamoto T, Tsunoda Y, Sherpa M, Sakurai H, Lin S, Matsuyama M, Matsuno Y, Morishima Y, Ishii Y, Hizawa N
- Organizer
  2018 International Conference of American Thoracic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15454
[Presentation] The role of T-bet in emphysema.2017
- Author(s)
  Hayashi S, Matsuno Y, Tsunoda Y, Sakurai H, Kiwamoto T, Kawaguchi M, Morishima Y, Ishii Y, Hizawa N.
- Organizer
  2017 International Conference of American Thoracic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15454
[Presentation] The Role of T-bet in Emphysema2017
- Author(s)
  Shigen Hayashi , Yousuke Matsuno , Yoshiya Tsunoda , Hirofumi Sakurai , Takumi Kiwamoto , Miou Kawaguchi , Yuko Morishima , Yukio Ishii , Nobuyuki Hizawa
- Organizer
  American Thoracic Society 2017 International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09571
[Presentation] The effect of sulforaphane on airway dysfunction in mice after chlorine gas exposure.2017
- Author(s)
  Ano S, Panariti A, Allard B, O’Sullivan M, McGovern TK, Hamamoto Y, Ishii Y, Powell WS, Martin JG.
- Organizer
  2017 International Conference of American Thoracic Society
- Data Source
  KAKENHI-PROJECT-16K15454
[Presentation] 異常活性化T細胞による肺胞蛋白症発症機構の解明2016
- Author(s)
  阿野哲士、菊池教大、石井幸雄
- Organizer
  第25回ＰｎｅｕｍｏＦｏｒｕｍ
- Place of Presentation
  経団連会館、東京都千代田区
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-16K15454
[Presentation] 動物モデルを用いた非結核性抗酸菌感染症宿主因子の検討2015
- Author(s)
  石井幸雄、松山政史．
- Organizer
  第90回日本結核病学会総会
- Place of Presentation
  長崎市
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-24591152
[Presentation] 動物実験モデルから考える肺MAC症の難治化病態2014
- Author(s)
  松山政史、石井幸雄、檜澤伸之．
- Organizer
  第89回日本結核病学会総会
- Place of Presentation
  岐阜市
- Year and Date
  2014-05-10
- Data Source
  KAKENHI-PROJECT-24591152
[Presentation] Role of ROR-γt in the development of pulmonary MAC infection in mice.2014
- Author(s)
  1.Matsuyama M, Ishii Y, Ohtsuka S, Ano S, Matsuno Y, Morishima Y, Hizawa N.
- Organizer
  2014 International Conference of American Thoracic Society
- Place of Presentation
  San Diego
- Year and Date
  2014-05-18
- Data Source
  KAKENHI-PROJECT-24591152
[Presentation] 肺MAC感染におけるT-betの役割2014
- Author(s)
  4.松山政史、石井幸雄、大塚茂男、阿野哲士、松野洋輔、森島祐子、檜澤伸之．
- Organizer
  第54回日本呼吸器学会学術講演会
- Place of Presentation
  大阪市
- Year and Date
  2014-04-27
- Data Source
  KAKENHI-PROJECT-24591152
[Presentation] Genetic ablation of Nrf2 exacerbates influenza virusinduced lung injury after cigarette smoke exposure in mice2010
- Author(s)
  Yageta Y, Kikuchi N, Ishii Y, et al.
- Organizer
  106th International Conference of American Thoracic Society
- Place of Presentation
  New Orleans(USA)
- Data Source
  KAKENHI-PROJECT-20590911
[Presentation] 転写因子T-betはブレオマイシン誘発肺線維症を抑制する2010
- Author(s)
  菊池教大、石井幸雄、原口典博、他
- Organizer
  第50回日本呼吸器学会学術講演会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590911
[Presentation] Nrf2-mediated cell prolife-ration is regulated by EGFR-MAPK signaling in Keap1 wild-type non-small cell lung cancer2010
- Author(s)
  Yamadori T, Ishii Y, Yageta Y, et al.
- Organizer
  106th International Conference of American Thoracic Society
- Place of Presentation
  New Orleans(USA)
- Data Source
  KAKENHI-PROJECT-20590911
[Presentation] LPS敗血症モデルにおけるPeroxiredoxin-Iの抑制効果2009
- Author(s)
  菊池教大、石井幸雄、本間晋介、他
- Organizer
  第49回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590911
[Presentation] The role of preoxiredoxin I in the pathogenesis of bleomycin-induced pulmonary inflammation and fibrosis2009
- Author(s)
  Kikuchi N, Ishii Y, Yageta Y, et al
- Organizer
  105th International Conference of American Thoracic Society
- Place of Presentation
  San Diego(USA)
- Data Source
  KAKENHI-PROJECT-20590911
[Presentation] LPS敗血症モデルにおけるPeroxiredoxin Iの抑制作用2009
- Author(s)
  菊池教大、石井幸雄, 他
- Organizer
  第49回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2009-06-13
- Data Source
  KAKENHI-PROJECT-20590911
[Presentation] 急性肺損傷および肺線維症に対するペルオキシレドキシンIの防御作用2008
- Author(s)
  菊池教大、石井幸雄、原口典博、他
- Organizer
  第48回日本呼吸器学会学術講演会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590911
[Presentation] 転写因子Nrf2によるブレオマイ、シン誘発肺傷害および肺線維症の制御2007
- Author(s)
  菊池教大・石井幸雄, 他
- Organizer
  第47回日本呼吸器学会学術講演会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2007-05-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590836
[Presentation] Role Of T-bet In The Development Of Pulmonary MAC Disease
- Author(s)
  M. Matsuyama, Y. Ishii, S. Otsuka, S. Ano, Y. Matsuno, Y. Morishima, N. Hizawa
- Organizer
  American Thoracic Society 2013 Conference
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-24591152
[Presentation] Role of T-bet in the development of pulmonary MAC disease
- Author(s)
  Matsuyama M, Ishii Y, Otsuka S, Ano S, Matsuno Y, Morishima Y, Hizawa N.
- Organizer
  American Thoracic Society International Meeting 2013
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-24591152
[Presentation] The role of A170/SQSTM1/p62 In Legionella Pneumophila pneumonia
- Author(s)
  Otsuka S, Matsuyama M, Ishii Y, Ano S, Matsuno Y, Morishima Y, Hizawa
- Organizer
  American Thoracic Society International Meeting 2013
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-24591152
[Presentation] The Role Of A170/SQSTM1/p62 In Legionella Pneumophila Pneumonia
- Author(s)
  S. Ohtsuka, M. Matsuyama, Y. Ishii, S. Ano, Y. Matsuno, Y. Morishima, N. Hizawa
- Organizer
  American Thoracic Society 2013 Conference
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-24591152
[Presentation] 遺伝子改変マウスを用いた肺MAC症病態生理の解明
- Author(s)
  松山政史、石井幸雄、檜澤伸之、小川賢二
- Organizer
  第87回日本結核病学会総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-24591152

1. MORISHIMA YUKO (10375511)

# of Collaborated Projects: 3 results

# of Collaborated Products: 21 results
2. Matsuno Yosuke (30633177)

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
3. NAKAJIMA Masayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. FUJITA Junichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. OTA Kyoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. HIZAWA Nobuyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
7. SAKAMOTO Tohru

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. KANEKO Shin

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 山本雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 松山政史

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
11. 川口未央

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 石井功

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 蕨栄治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. SHERPA MINGMA

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
15. 際本拓未

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 渋谷彰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 渋谷和子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 中内啓光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 野口恵美子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ishii Yukio 石井 幸雄

ISHII Yukio 石井 幸雄

石井 幸夫 イシイ ユキオ

石井 幸雄 イシイ ユキオ

Research Projects

Research Products

Co-Researchers

The Role of Metabolic Reprogramming-Induced Cell Differentiation in the Development of Pulmonary Fibrosis

Principal Investigator

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Review Section

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The role of oxidative stress on agingPrincipal Investigator

Principal Investigator

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Review Section

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The role and regulatory mechanisms of ROS signaling in the pathogensis of pulmonary fibrosis

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Elucidation of the mechanism of T-bet-mediated induction of pulmonary alveolar proteinosisPrincipal Investigator

Principal Investigator

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Cross-talk between Th cells and inflammatory macrophages in chronic inflammatory respiratory diseases

Principal Investigator

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Identification of host factors which protect against the development of pulmonary inflammation induced by intracellular pathogensPrincipal Investigator

Principal Investigator

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肺胞蛋白症の新たな病態:転写因子T-betによるGM-CSF非依存性の発症機構

Principal Investigator

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Role of Keap1/Nrf2 system in host defense against acute lung injury.Principal Investigator

Principal Investigator

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The protective role of Nrf2 in the development of acute lung injury and pulmonary fibrosisPrincipal Investigator

Principal Investigator

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Research Institution

The effects of α-galactosylceramide on the development of bleomycin-induced pulmonary fibrosisPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

混合ガス曝露による肺線維症モデルの確立と同モデルの分子生物学的解析Principal Investigator

Principal Investigator

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Research Institution

肺損傷の可逆性と肺内浸潤好中球のアポトーシスとの関係についてPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

[Book] 肺MAC症におけるTh1細胞の役割. 肺MAC症診療 Up to Date2013

Ishii Yukio 石井幸雄

ISHII Yukio 石井幸雄

石井幸夫イシイユキオ

石井幸雄イシイユキオ