NISHIMOTO Norihiro 西本憲弘

… Alternative Names

西本憲弘ニシモトノリヒロ

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Researcher Number	80273663
Other IDs
External Links
Affiliation (Current)	2025: 東京医科大学, 医学部, 兼任教授
Affiliation (based on the past Project Information) *help	2013 – 2021: 東京医科大学, 医学部, 兼任教授 2017: 東京医科大学, 医学総合研究所, 兼任教授 2013: 東京医科大学, 医学部, 教授 2008 – 2013: 和歌山県立医科大学, 医学部, 教授 2003 – 2007: Osaka University, Osaka University, Frontier Biosciences, Professor … More 2003: 大阪大学, 生命機能研究科, 客員教授 2002: 大阪大学, 健康体育部, 助教授 1996 – 2000: 大阪大学, 健康体育部, 助教授 1995 – 1996: 大阪大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator 内科学一般 / 膠原病・アレルギー・感染症内科学 / Collagenous pathology/Allergology / Biological Sciences / Immunology / Kidney internal medicine Except Principal Investigator 膠原病・アレルギー・感染症内科学 / Collagenous pathology/Allergology / Hematology / Thoracic surgery … More / Orthopaedic surgery / Sports science / 内科学一般 / 免疫の制御機構 / Immunology Less
Keywords	Principal Investigator SSI-1 / 関節リウマチ / SOCS-1 / インターロイキン6(IL-6) / インターフェロン / 全身性エリテマトーデス / DNAマイクロアレイ / インターロイキン6 / IL-6 / drug efficacy … More / immunology / DNA microarray / signal transduction / defensin-α / defellsin-α / インターフェロンα / IL-6阻害治療 / トシリズマブ / ヒト化抗IL-6受容体抗体 / 若年性特発性関節炎 / negative regulator / adenoviral vector / vascular endothelial growth factor / humanized anti-IL-6 receptor antibody / interleukin-6 / rheumatoid arthritis / アデノウイルスベクター / 負の調節因子 / アデノウイルス / 血管内皮増殖因子(VEGF) / ヒト化抗IL-6レセプター抗体 / Negative feedback / IL-6 receptor / Humanized Antibody / TNFα / Interleukin 6 (IL-6) / Cytokine / Rheumatoid Arthritis / 滑膜細胞 / ネガティブフィードバック / 可溶性IL-6レセプター / ヒト型化抗体 / 腫瘍壊死因子(TNFα) / サイトカイン / 慢性関節リウマチ / iPS細胞 / ヒト人工多能性幹細胞(iPS細胞） / 関節 / ヒト人工多能性幹細胞（iPS細胞） / 破骨細胞 / ヒト人工多能性幹細胞（iPS細胞) / 単球 / 骨髄 / S100タンパク / 年性特発性関節炎 / defensin / cell adhesion / バイオインフォーマティクス / S100ファシリー分子 / シトコンドリア / DNA修復分子 / バイオインフォマティクス / リウマチ学 / 薬剤反応性 / 免疫学 / マイクロアレイ / プロテオーム / シグナル伝達 / 二次性アミロイドーシス / メタプロテアーゼ / 血管新生 / 滑膜増殖 / ヒト型抗IL-6レセプター抗体 / RA / T細胞分化 / アポトーシス / 胸腺 / JVSマウス / カルニチン / IL-6トランスジェニックマウス / オールトランスレチノイン酸 / メサンギウム増殖性腎炎 … More Except Principal Investigator 関節リウマチ / IL-6 / SSI-1 / STAT3 / STAT1 / MAPK / サイトカイン / ネガティブフィードバック / シグナル伝達機構 / 多発性骨髄腫 / 関節リウマチ（RA） / 関節リウマチ（RA) / IL-17産生CD8+T 細胞 / １．乾癬性関節炎（PsA） / IL-17 産生CD8+T 細胞 / リンパ球 / 乾癬性関節炎（PsA） / リンパ球サブセット / 乾癬性関節炎 / negative feedback / multiple myeloma / インターロイキン6 / STAT / アバタセプト / Ｔ細胞 / Interleukin-6 / CD25 / CD4 / B細胞 / T細胞 / トシリズマブ / interleukin-6 / 悪性胸膜中皮腫 / 三次元培養 / 間葉系幹細胞 / 運動器細胞 / 力学刺激 / メカノトランスダクション / 滑膜細胞 / 半月板細胞 / 軟骨細胞 / 運動器組織 / 三次元組織 / メカニカルストレス / DNAマイクロアレイ / ミトコンドリア遺伝子 / DNA修復酵素 / SLE / 光線過敏 / KOマウス / アデノウイルスベクター / S100タンパク / 再生 / 遺伝子 / プロテオーム / 脳 / 骨格筋 / 筋再生 / プロテオミクス / 感覚神経 / 脳機能 / 筋活動 / KSHV / HHV8 / 血清アミロイドA / AAアミロイドーシス / VEGF / 血管新生 / ヒト型化抗IL-6受容体抗体療法 / キャッスルマン病 / STAT-3 / STAT-1 / ミエローマ / 慢性関節リウマチ / Castleman病 / IL-6のシグナル伝達阻害 / ヒト型化抗IL-6受容体抗体 / チロシンリン酸化 / シグナル伝達分子 / 増殖分化 / インターリウキン6 Less

Analysis of lymphocyte subsets in psoriatic arthritis
- Principal Investigator
  
  Murakami Miho
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Tokyo Medical University
Elucidation of differentiation and function abnormalities of bone marrow mesenchymal cells using human induced pluripotent stem cell cells derived from patients with rheumatoid arthritis.Principal Investigator
- Principal Investigator
  
  Nishimoto Norihiro
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Tokyo Medical University
The difference of immune modification in rheumatoid arthritis patients between IL-6 blockade with tocilizumab and T cell inactivation with abatacept
- Principal Investigator
  
  MURAKAMI Miho
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Tokyo Medical University
ヒト試料を用いたアバタセプト（ＣＴＬＡ４－Ｉｇ）のリウマチ治療効果発現機序の解明
- Principal Investigator
  
  松谷隆治
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Wakayama Medical University
Mechano-signal transduction against 3-D mechanical stress in human connective tissue cells and MCS
- Principal Investigator
  
  NAKATA Ken
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Osaka University
Interleukin-6 (IL-6) receptor antibody therapy to malignant pleural mesothelioma
- Principal Investigator
  
  MATSUMOTO Seiji
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Hyogo Medical University
SLE光線過敏症におけるDNA修復酵素XPD,XPGの機能解明
- Principal Investigator
  
  杉野英彦
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Osaka University
Study of pathogenic mechanism of autoimmune diseases using the evidence from anti-IL-6 therapyPrincipal Investigator
- Principal Investigator
  
  NISHIMOTO Norihiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Wakayama Medical University
関節リウマチにおけるカルシウム結合タンパクS100の機能解明
- Principal Investigator
  
  SUGINO Hidehiko
- Project Period (FY)
  2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Osaka University
Promotion of muscle activities as the countermeasure for prevention of the deterioration of brain function
- Principal Investigator
  
  OHIRA Yoshinobu
- Project Period (FY)
  2007 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Sports science
- Research Institution
  Osaka University
Establishment of the anti-IL-6 receptor therapy for refractory autoimmune diseasesPrincipal Investigator
- Principal Investigator
  
  NISHIMOTO Norihiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Osaka University
免疫情報シグナル制御による免疫監視異常の修復Principal Investigator
- Principal Investigator
  
  西本憲弘
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Research of molecular biology and gene therapy for Rheumatoid arthritis by regulation of IL-6 signal transductionPrincipal Investigator
- Principal Investigator
  
  NISHIMOTO Norihiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Osaka University
IL-6シグナル制御による慢性関節リウマチの分子・遺伝子治療の研究Principal Investigator
- Principal Investigator
  
  西本憲弘
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Osaka University
キャッスルマン病の病因・病態解析とIL-6阻害による治療研究
- Principal Investigator
  
  吉崎和幸
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Osaka University
多発性骨髄腫のサイトカインシグナル伝達におけるネガティブフォードバック機構の解析-SSI-1導入による遺伝子治療の試み-
- Principal Investigator
  
  吉崎和幸
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Osaka University
カルニチン輸送担体異常マウス(JVSマウス)における胸腺アポトーシス現象の解析Principal Investigator
- Principal Investigator
  
  西本憲弘
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Osaka University
Study for molecular and gene therapy of rheumatoid arthritis by targeting IL-6 signal transduction.Principal Investigator
- Principal Investigator
  
  NISHIMOTO Norihiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Osaka University
Signal transduction of IL-6 in myeloma cells
- Principal Investigator
  
  YOSHIZAKI Kazuyuki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Hematology
- Research Institution
  Osaka University
レチノイン酸並びに抗IL-6レセプター抗体によるメサンギウム増殖性腎炎の治療Principal Investigator
- Principal Investigator
  
  西本憲弘
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Osaka University
IL-6シグナル伝達阻害による新しい治療法の開発
- Principal Investigator
  
  吉崎和幸
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  免疫の制御機構
- Research Institution
  Osaka University
多発性骨髄腫細胞におけるIL-6シグナル伝達機構の解析
- Principal Investigator
  
  YOSHIZAKI Kazuyuki
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Osaka University

[Book] 膠原病・リウマチ・アレルギー研修ノート2016
- Author(s)
  村上美帆、西本憲弘、山本一彦、住友秀次、亀田秀人、保田晋助、寺井千尋、山崎聡、山岡邦宏、細矢　匡、原田広顕，奥西勝秀、大村浩一郎、山本元久，高橋裕樹、久保智史，田中良哉、石井智徳、松下　功、澤井高志、他
- Total Pages
  574
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-25461481
[Book] 骨ペディア2015
- Author(s)
  西本憲弘、村上美帆、秋山治彦、安倍正博、網塚憲生、飯村忠浩、池川志郎、石井優、石丸大地、井関祥子、伊東昌子、稲田全規、井上大輔、今井祐記、今泉和則、今村健志、岩本潤、宇田川信之、江面陽一、遠藤直人、他
- Total Pages
  327
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-25461481
[Book] 免疫・アレルギー疾患の分子標的と治療薬事典―生物学的製剤、低分子化合物のターゲット分子と作用機序、薬効のすべて2013
- Author(s)
  田中良哉編：西本憲弘、村上美帆
- Total Pages
  375
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-25461481
[Book] リウマチ病セミナーXXIV2013
- Author(s)
  七川歡次監修：西本憲弘，村上美帆
- Total Pages
  247
- Publisher
  永井書店
- Data Source
  KAKENHI-PROJECT-25461481
[Book] ADDRESSING UNMET MEDICAL NEEDS IN RHEUMATOID ARTHRITIS2012
- Author(s)
  Nishimoto N, Murakami M, Mastutani T
- Total Pages
  16
- Publisher
  Future Science Group E-Books Program
- Data Source
  KAKENHI-PROJECT-21390299
[Book] トシリズマブケーススタディー-最新バイオロジクス治療から学ぶRA診療の注意点-2010
- Author(s)
  西本憲弘
- Total Pages
  61
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-21390299
[Book] 運動と無重力環境と免疫2009
- Author(s)
  大平宇志、西本憲弘、大平充宣
- Publisher
  ナップ
- Data Source
  KAKENHI-PROJECT-19100009
[Book] アレルギー・リウマチ膠原病の最新医療2003
- Author(s)
  西本憲弘
- Total Pages
  473
- Publisher
  寺田国際事務所/先端医療技術研究所
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370163
[Book] Targeted Therapies in Rheumatology2002
- Author(s)
  Nishimoto N, et al.
- Total Pages
  768
- Publisher
  Taylor & Francis, A Martin Dunitz Book
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370163
[Journal Article] IL-6 阻害薬と関節リウマチの骨・軟骨病変の制御2015
- Author(s)
  村上美帆　西本憲弘
- Journal Title
  
  CLINICAL CALＣIUM
  
  Volume: 25 Pages: 1851-1857
- Open Access
- Data Source
  KAKENHI-PROJECT-25461481
[Journal Article] Immune response to influenza vaccine and pneumococcal polysaccharide vaccine under IL-6 signal inhibition therapy with tocilizumab.2014
- Author(s)
  Tsuru T, Terao K, Murakami M, Matsutani T, Suzaki M, Amamoto T, Nakashima H, Akiyama A, Nishimoto N.
- Journal Title
  
  Mod Rheumatol.
  
  Volume: 24 Issue: 3 Pages: 511-516
- DOI
  10.3109/14397595.2013.843743
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461481
[Journal Article] 生物学的製剤：使い方と安全性トシリズマブ -IV vs SC-2014
- Author(s)
  西本憲弘，村上美帆
- Journal Title
  
  Mebio
  
  Volume: 31 Pages: 54-61
- Data Source
  KAKENHI-PROJECT-25461481
[Journal Article] KSHV関連Castleman病におけるヒトおよびウイルスIL-6の役割2014
- Author(s)
  村上美帆, 西本憲弘
- Journal Title
  
  血液内科
  
  Volume: 69 Pages: 449-454
- NAID
  40020208006
- Data Source
  KAKENHI-PROJECT-25461481
[Journal Article] Retreatment efficacy and safety of tocilizumab in patients with rheumatoid arthritis in recurrence (RESTORE) study.2014
- Author(s)
  Nishimoto N, Amano K, Hirabayashi Y, Horiuchi T, Ishii T, Iwahashi M, Iwamoto M, Kohsaka H, Kondo M, Matsubara T, Mimura T, Miyahara H, Ohta S, Saeki Y, Saito K, Sano H, Takasugi K, Takeuchi T, Tohma S, Tsuru T, Ueki Y, Yamana J, Hashimoto J, Matsutani T, Murakami M, Takagi N.
- Journal Title
  
  Mod Rheumatol
  
  Volume: 24(1) Issue: 1 Pages: 26-32
- DOI
  10.3109/14397595.2013.854080
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461481
[Journal Article] 炎症性自己免疫疾患における治療標的としてのIL-62013
- Author(s)
  西本憲弘，村上美帆
- Journal Title
  
  日本臨床増刊号「血管炎」
  
  Volume: 71（増刊号1） Pages: 623-629
- Data Source
  KAKENHI-PROJECT-25461481
[Journal Article] Blocking the effects of interleukin-6 in rheumatoid arthritis and other inflammatory rheumatic diseases: systematic literature review and meta-analysis informing a consensus statement.2013
- Author(s)
  Schoels MM, van der Heijde D, Breedveld FC, Burmester GR, Dougados M, Emery P, Ferraccioli G, Gabay C, Gibofsky A, Gomez-Reino JJ, Jones G, Kvien TK, Murakami M, Nishimoto N, Smolen JS.
- Journal Title
  
  Ann Rheum Dis
  
  Volume: 72(4) Issue: 4 Pages: 583-589
- DOI
  10.1136/annrheumdis-2012-202470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461481
[Journal Article] Consensus statement on blocking the effects of interleukin-6 and in particular by interleukin-6 receptor inhibition in rheumatoid arthritis and other inflammatory conditions2013
- Author(s)
  Smolen JS, Schoels MM, Nishimoto N, Breedveld FC, Burmester GR, Dougados M, Emery P, Ferraccioli G, Gabay C, Gibofsky A, Gomez-Reino JJ, Jones G, Kvien TK, Murakami M, 他21名
- Journal Title
  
  Ann Rheum Dis
  
  Volume: 72(4) Issue: 4 Pages: 482-492
- DOI
  10.1136/annrheumdis-2012-202469
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461481
[Journal Article] 水銀による自己抗体産生誘導．臨床免疫・アレルギー科2013
- Author(s)
  松谷隆治，村上美帆，西本憲弘
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 59（5） Pages: 611-613
- Data Source
  KAKENHI-PROJECT-25461481
[Journal Article] Drug free REmission/low disease activity after cessation of tocilizumab (Actemra) Monotherapy (DREAM) study.2013
- Author(s)
  Nishimoto N, Amano K, Hirabayashi Y, Horiuchi T, Ishii T, Iwahashi M, Iwamoto M, Kohsaka H, Kondo M, Matsubara T, Mimura T, Miyahara H, Ohta S, Saeki Y, Saito K, Sano H, Takasugi K, Takeuchi T, Tohma S, Tsuru T, Ueki Y, Yamana J, Hashimoto J, Matsutani T, Murakami M, Takagi N.
- Journal Title
  
  Mod Rheumatol
  
  Volume: 24(1) Issue: 1 Pages: 17-25
- DOI
  10.3109/14397595.2013.854079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461481
[Journal Article] 成人病発症Still病2013
- Author(s)
  西本憲弘，村上美帆
- Journal Title
  
  内科
  
  Volume: 112（1） Pages: 73-76
- Data Source
  KAKENHI-PROJECT-25461481
[Journal Article] Tocilizumab in the treatment of systemic juvenile idiopathic arthritis2012
- Author(s)
  Murakami M, Minako T, Nishimoto N
- Journal Title
  
  Open Access Rheumatolgy : Research and Reviews
  
  Volume: (in press)(未)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese2012
- Author(s)
  岡田随象
- Journal Title
  
  PLoS Genetics
  
  Volume: (掲載確定) Issue: 1 Pages: 1002455-1002455
- DOI
  10.1371/journal.pgen.1002455
- NAID
  120005906866
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00226, KAKENHI-PLANNED-19059005, KAKENHI-PROJECT-20689029, KAKENHI-PROJECT-21390299, KAKENHI-PROJECT-21591258, KAKENHI-PROJECT-21591277, KAKENHI-PLANNED-22021023, KAKENHI-PLANNED-22116010, KAKENHI-PROJECT-22591074, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-23590379, KAKENHI-PROJECT-23689051, KAKENHI-PROJECT-24591436
[Journal Article] Effects of Mechanical Over-loading on the Properties of Soleus Muscle Fibers, with or without Damage, in Wild Type and Mdx Mice2012
- Author(s)
  Terada M, Kawano F, Ohira T, Nakai N, Nishimoto N, Ohira Y
- Journal Title
  
  PLoS ONE
  
  Volume: (in press)(未)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Underexpression of mitochondrial-DNA encoded ATP synthesis-related genes and DNA repair genes in systemic lupus erythematosus2011
- Author(s)
  Lee HM, Sugino H, Aoki C, Nishimoto N.
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 13(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Abnormal networks of immune response-related molecules in bone marrow cells from patients with rheumatoid arthritis as revealed by DNA microarray analysis2011
- Author(s)
  Lee HM, Sugino H, Aoki C, Shimaoka Y, Suzuki R, Ochi K, Ochi T, Nishimoto N.
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 13(3)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Humanized anti-interleukin-6-receptor antibody (tocilizumab) monotherapy is more effective in slowing radiographic progression in patients with rheumatoid arthritis at high baseline risk for structural damage evaluated with levels of biomarkers, radiography, and BMI : data from the SAMURAI study2011
- Author(s)
  Hashimoto J, Garnero P, van der Heijde D, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Yoshikawa H, Nishimoto N
- Journal Title
  
  Mod Rheumatol
  
  Volume: 21 Issue: 1 Pages: 10-15
- DOI
  10.1007/s10165-010-0325-3
- NAID
  10029361106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Severity-based treatment for Japanese patients with MPO-ANCA-associated vasculitis : the JMAAV study2011
- Author(s)
  Ozaki S, Atsumi T, Hayashi T, Ishizu A, Kobayashi S, Kumagai S, Kurihara Y, Kurokawa M, Makino H, Nagafuchi H, Nakabayashi K, Nishimoto N, Suka M, Tomino Y, Yamada H, Yamagata K, Yoshida M, Yumura W
- Journal Title
  
  Mod Rheumatol
  
  Volume: (Epub ahead of print) Issue: 3 Pages: 394-404
- DOI
  10.1007/s10165-011-0525-5
- NAID
  10030782228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299, KAKENHI-PROJECT-22590569, KAKENHI-PROJECT-22591074, KAKENHI-PROJECT-23590553, KAKENHI-PROJECT-24659171
[Journal Article] Humanized anti-interleukin-6-receptor antibody (tocilizumab) monotherapy is more effective in slowing radiographic progression in patients with rheumatoid arthritis at high baseline risk for structural damage evaluated with levels of biomarkers, radiography, and BMI : data from the SAMURAI study.2011
- Author(s)
  Hashimoto J, Garnero P, van der Heijde D, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Yoshikawa H, Nishimoto N.
- Journal Title
  
  Mod Rheumatol
  
  Volume: 21 Pages: 10-15
- NAID
  10029361106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Study Investigators. Radiological features and therapeutic responses of pulmonary nontuberculous mycobacterial disease in rheumatoid arthritis patients receiving biological agents : a retrospective multicenter study in Japan2011
- Author(s)
  Mori S, Tokuda H, Sakai F, Johkoh T, Mimori A, Nishimoto N, Tasaka S, Hatta K, Matsushima H, Kaise S, Kaneko A, Makino S, Minota S, Yamada T, Akagawa S, Kurashima A, the NTM-BIORA (NTM infection in Biologic-treated RA patients)
- Journal Title
  
  Mod Rheumatol
  
  Volume: (Epub ahead of print) Issue: 5 Pages: 727-737
- DOI
  10.1007/s10165-011-0577-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] The value of blocking IL-6 outside of rheumatoid arthritis : current pers pective2011
- Author(s)
  Murakami M, Nishimoto N
- Journal Title
  
  Curr Opin Rheumatol
  
  Volume: 23 Issue: 3 Pages: 273-277
- DOI
  10.1097/bor.0b013e3283456797
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Serum level of oxidative stress marker is dramatically low in patients with rheumatoid arthritis treated with tocilizumab2011
- Author(s)
  Hirao M, Yamasaki N, Oze H, Ebina K, Nampei A, Kawato Y, Shi K, Yoshikawa H, Nishimoto N, Hashimoto J.
- Journal Title
  
  Rheumatol Int
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Interleukin-6 modulates graft-versus-host responses after experimental a llogeneic bone marrow transplantation2011
- Author(s)
  Tawara I, Koyama M, Toubai T, Liu C, Nieves E, Sun Y, Lowler KP, Malter C, Evers R, Nishimoto N, Hill GR, Reddy P
- Journal Title
  
  Clin Cancer Res
  
  Volume: 17 Issue: 1 Pages: 77-88
- DOI
  10.1158/1078-0432.ccr-10-1198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Abnormal networks of immune response-related molecules in bone marrow cells from patients with rheumatoid arthritis as revealed by DNA microarray analysis2011
- Author(s)
  Lee HM, Sugino H, Aoki C, Shimaoka Y, Suzuki R, Ochi K, Ochi T, Nishimoto N
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 13 Issue: 3
- DOI
  10.1186/ar3364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation2011
- Author(s)
  Tawara I, Koyama M, Toubai T, Liu C, Nieves E, Sun Y, Lowler KP, Malter C, Evers R, Nishimoto N, Hill GR, Reddy P.
- Journal Title
  
  Clin Cancer Res
  
  Volume: 17 Pages: 77-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Diagnostic features of mild cellulitis phlegmon in patients with rheumatoid arthritis treated with tocilizumab : a report of two cases2011
- Author(s)
  Hirao M, Nampei A, Shi K, Yoshikawa H, Nishimoto N, Hashimoto J
- Journal Title
  
  Mod Rheumatol
  
  Volume: 21 Issue: 6 Pages: 673-677
- DOI
  10.1007/s10165-011-0459-y
- NAID
  10030206354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Humanized anti-interleukin-6-receptor antibody(tocilizumab) monotherapy is more effective in slowing radiographic progression in patients with rheumatoid arthritis at high baseline risk for structural damage evaluated with levels of biomarkers, radiography, and BMI : data from the SAMURAI study2011
- Author(s)
  Hashimoto J, Garnero P, van der Heijde D, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Yoshikawa H, Nishimoto N.
- Journal Title
  
  Mod Rheumatol
  
  Volume: 21 Pages: 10-15
- NAID
  10029361106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Incidence of serious respiratory infections in patients with rheumatoid a rthritis treated with tocilizumab2011
- Author(s)
  Hoshi D, Nakajima A, Inoue E, Shidara K, Sato E, Kitahama M, Seto Y, Tanaka E, Urano W, Ichikawa N, Koseki Y, Momohara S, Taniguchi A, Nishimoto N, Yamanaka H
- Journal Title
  
  Mod Rheumatol
  
  Volume: 22 Issue: 1 Pages: 122-127
- DOI
  10.1007/s10165-011-0488-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Shortening of complementarity determining region 3 of the T cell receptor α chain during thymocyte development2011
- Author(s)
  Matsutani T, Ogata M, Fujii Y, Kitaura K, Nishimoto N, Suzuki R, Itoh T.
- Journal Title
  
  Mol Immunol
  
  Volume: 48 Pages: 623-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Increased positive selection pressure within the CDR regions of the T cell receptor β gene in New World monkeys2011
- Author(s)
  Matsutani T, Fujii Y, Kitaura K, Suzuki S, Tsuruta Y, Itoh T, Nishimoto N, Takasaki T, Kurane I, Suzuki R
- Journal Title
  
  Am J Primatol
  
  Volume: 73 Issue: 10 Pages: 1082-1092
- DOI
  10.1002/ajp.20976
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299, KAKENHI-PROJECT-22390093, KAKENHI-PROJECT-22390370, KAKENHI-PROJECT-23659291
[Journal Article] Shortening of complementarity determining region 3 of the T cell recept or α chain during thymocyte development2011
- Author(s)
  Matsutani T, Ogata M, Fujii Y, Kitaura K, Nishimoto N, Suzuki R, Itoh T
- Journal Title
  
  Mol Immunol
  
  Volume: 48 Issue: 4 Pages: 623-629
- DOI
  10.1016/j.molimm.2010.11.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Underxpression of mitochondrial-DNA encoded ATP synthesis-related genes and DNA repair genes in systemic lupus erythematosus2011
- Author(s)
  Lee HM, Sugino H, Aoki C, Nishimoto N
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 13 Issue: 2
- DOI
  10.1186/ar3317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Value of serum IgG4 in the diagnosis of IgG4-related disease and in differentiation from rheumatic diseases and other diseases2011
- Author(s)
  Yamamoto M, Tabeya T, Naishiro Y, Yajima H, Ishigami K, Shimizu Y, Obara M, Suzuki C, Yamashita K, Yamamot H, Hayashi T, Sasaki S, Suzuki Y, Nishimoto N, Honda S, Takahashi H, Imai K, Shinomura Y
- Journal Title
  
  Mod Rheumatol
  
  Volume: (Epub ahead of print) Issue: 3 Pages: 419-25
- DOI
  10.1007/s10165-011-0532-6
- NAID
  10030782295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299, KAKENHI-PROJECT-23390398, KAKENHI-PROJECT-24659750
[Journal Article] Safety and efficacy of tocilizumab, an anti-IL-6-receptor monoclonal antibody, in patients with polyarticular-course juvenile idiopathic arthritis2011
- Author(s)
  Imagawa T, Yokota S, Mori M, Miyamae T, Takei S, Imanaka H, Nerome Y, Iwata N, Murata T, Miyoshi M, Nishimoto N, Kishimoto T
- Journal Title
  
  Mod Rheumatol
  
  Volume: 22 Issue: 1 Pages: 109-115
- DOI
  10.1007/s10165-011-0481-0
- NAID
  10030207067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Serum level of oxidative stress marker is dramatically low in patients with rheumatoid arthritis treated with tocilizumab2011
- Author(s)
  Hirao M, Yamasaki N, Oze H, Ebina K, Nampei A, Kawato Y, Shi K, Yoshikawa H, Nishimoto N, Hashimoto J
- Journal Title
  
  Rheumatol Int
  
  Volume: (Epub ahead of print) Issue: 12 Pages: 4041-4045
- DOI
  10.1007/s00296-011-2135-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] DNA microarray analysis of rheumatoid arthritis susceptibility genes identified by genome-wide association studies (GWAS)2010
- Author(s)
  Sugino H, Lee HM, Nishimoto N.
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 12 Pages: 401-401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] DNA microarray analysis of rheumatoid arthritis susceptibility genes identified by genome-wide association studies(GWAS)2010
- Author(s)
  Sugino H, Lee HM, Nishimoto N.
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 12 Pages: 401-401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Safety and efficacy profiles of tocilizumab monotherapy in Japanese patients with rheumatoid arthritis-meta-analysis of 6 initial trials and 5 long-term extensions-2010
- Author(s)
  Nishimoto N, Ito K, Takagi N
- Journal Title
  
  Mod Rheumatol (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Early administration of IL-6RA does not prevent radiation-induced lung injury in mice.2010
- Author(s)
  Ogata T, Yamazaki H, Teshima T, Kihara A, Suzumoto Y, Inoue T, Nishimoto N, Matsuura N.
- Journal Title
  
  Radiat Oncol
  
  Volume: 5:26(Web)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] VEGF targeting in mesotheliomas using an interleukin-6 signal inhibitor based on adenovirus gene delivery.2010
- Author(s)
  Adachi Y, Yoshio-Hoshino N, Aoki C, Nishimoto N.
- Journal Title
  
  Anticancer Res
  
  Volume: 30 Pages: 1947-1952
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Myonucleus-related properties in soleus muscle fibers of mdx mice2010
- Author(s)
  Terada, M., Y. B. Lan. F. Kawano, T. Ohira, Y. Higo, N. Nakai, K. Imaizumi, A. Ogura, N. Nishimoto, Y. Adachi, and Y. Ohira
- Journal Title
  
  Cells Tissues Organs
  
  Volume: 191 Pages: 248-259
- Data Source
  KAKENHI-PROJECT-19100009
[Journal Article] VEGF targeting in mesotheliomas using an interleukin-6 signal inhibitor based on adenovirus gene delivery2010
- Author(s)
  Adachi Y, Yoshio-Hoshino N, Aoki C, Nishimoto N
- Journal Title
  
  Articancer Res (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Assessment of the validity of the 28-joint disease activity score using erythrocyte sedimentation rate (DAS28-ESR) as a disease activity index of rheumatoid arthritis in the efficacy evaluation of 24-week treatment with tocilizumab : subanalysis of the SATORI study.2010
- Author(s)
  Nishimoto N, Takagi N.
- Journal Title
  
  Mod Rheumatol
  
  Volume: 20 Pages: 539-547
- NAID
  10027647281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Safety and efficacy profiles of tocilizumab monotherapy in Japanese patients with rheumatoid arthritis -meta-analysis of 6 initial trials and 5 long-term extensions-2010
- Author(s)
  Nishimoto N, Ito K, Takagi N.
- Journal Title
  
  Mod Rheumatol
  
  Volume: 20 Pages: 222-232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Cytokine networks in systemic lupus erythematosus2010
- Author(s)
  Lee H, Sugino H, Nishimoto N
- Journal Title
  
  J Biomed Biotechnal (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Interleukin-6 as a therapeutic target in candidate inflammatory diseases2010
- Author(s)
  Nishimoto N
- Journal Title
  
  Clin Pharmacol Ther 87
  
  Pages: 483-487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Interleukin-6 as a therapeutic target in candidate inflammatory diseases2010
- Author(s)
  Nishimoto N
- Journal Title
  
  Clin Pharmacol Ther
  
  Volume: 87 Pages: 483-487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Cytokine networks in systemic lupus erythematosus2010
- Author(s)
  Lee HM, Sugino H, Nishimoto N
- Journal Title
  
  J Biomed Biotechnol 2010
  
  Volume: 2010 Pages: 676284-676284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Myonucleus-related properties in soleus muscle fibers of mdx mice2010
- Author(s)
  Terada, M., Y. B. Lan. F. Kawano, T. Ohira, Y. Higo, N. Nakai, K. Imaizumi, A. Ogura, N. Nishimoto, Y. Adachi, Y. Ohira
- Journal Title
  
  Cells Tissues Organs 191
  
  Pages: 248-259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19100009
[Journal Article] DNA microarray analysis of rheumatoid arthritis susceptibility genes identified by genome-wide association studies(GWAS)2010
- Author(s)
  Sugino H, Lee H, Nishimoto N
- Journal Title
  
  Arthritis Res Ther 12
  
  Pages: 401-401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Cytokine networks in systemic lupus erythematosus.2010.2010
- Author(s)
  Lee HM, Sugino H, Nishimoto N.
- Journal Title
  
  J Biomed Biotechnol
  
  Volume: 2010:676284(Web)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Early administration of IL-6RA does not prevent radiation-induced lung injury in mice.2010
- Author(s)
  Ogata T, Yamazaki H, Teshima T, Kihara A, Suzumoto Y, Inoue T, Nishimoto N, Matsuura N
- Journal Title
  
  Radiat Oncol 12
  
  Pages: 401-401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Myonucleus-related properties in soles muscle fibers of mdx Mice.20092009
- Author(s)
  Terada M, Yong Bo Lan, Kawano F, Ohira T, Higo Y, Nakai N, Imaizumi K, Ogura A, Nishimoto N, Adachi Y, Ohira Y
- Journal Title
  
  Cell Tissues Organs 191
  
  Pages: 248-259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Interaleukin-11 and paired immunoglobulin-like type 2 receptor alpha expression correlates with tha number of joints with active arthritis in systemic juvenile idiopathic arthritis2009
- Author(s)
  Mima T, Ishikawa S, Aoki C, Yoshio-Hoshino N, Adachi Y, Imagawa T, Mori M, Tomiita M, Iwata N, Murata T, Miyoshi M, Takei S, Aihara Y, Yokota S, Matsubara K, Nishimoto N.
- Journal Title
  
  Ann Rheum Dis
  
  Volume: 68 Pages: 286-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] A case report of a patient with refractory adult-onset Still's disease who successfully treated with Tocilizumab over 6years2009
- Author(s)
  Nakahara H, Mima T, Hoshino Yoshio-Naoko, Matsushita M, Hashimoto J, Nishimoto N
- Journal Title
  
  Mod Rheumatol 19
  
  Pages: 69-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Study of active controlled tocilizumab monotherapy for rheumatoid artriris patients with an inadequate response to methotrexate(SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy2009
- Author(s)
  Nishimoto N, Miyasaka N, Yamamloto K, Kawai S, Takeuchi T, Azumi J., Kishimoto T
- Journal Title
  
  Mod Rheumatol 19
  
  Pages: 12-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Specifically modified osteopontin in rheumatoid arthritis fibroblast-like synoviocytes supports interaction with B cells and enhances IL-6 production2009
- Author(s)
  Take Y, Nakata K, Hashimoto J, Tsuboi H, Nishimoto N, Ochi T, Yoshikawa H.
- Journal Title
  
  Arthritis Rheum
  
  Volume: 60 Pages: 3591-3601
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Clinical value of blocking IL-6 receptor. 2009 ;(5)2009
- Author(s)
  Mima T, Nishimoto N
- Journal Title
  
  Current Opimion in Rheumatology 21
  
  Pages: 224-230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Abnormal expression of the genes involved in cytokine networks and mitochondrial function in systemic juvenile idiopathic arthritis identified by DNA microarray analysis2009
- Author(s)
  Ishikawa S, Mima T, Aoki C, Yoshio-Hoshino N, Adachi Y, Imagawa T, Mori M, Tomiita M, Iwata N, Murata T, Miyoshi M, Takei S, Aihara Y, Yokota S, Matsubara K, Nishimoto N.
- Journal Title
  
  Ann Rheum Dis
  
  Volume: 68 Pages: 264-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Specifically modified osteopontin in rheumatoid arthritis fibroblast-like synoviocytes supports interaction with B cells and enhances production of IL-62009
- Author(s)
  Take Y, Nakata K, Hashimoto J, Tsuboi H, Nishimoto N, Ochi T, Yoshikawa H
- Journal Title
  
  Arthritis Rheum 60
  
  Pages: 3591-3601
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Effect of Interleukin-6 Receptor Blockage on Renal Injury in Apolipoprotein E-Deficient Mice2009
- Author(s)
  Tomiyama-Hanayama M, Rakugi H, Kohara M, Mima T, Adachi Y, Ohishi M, Katsuya T, Hoshida Y, Aozasa K, Ogihara T, Nishimoto N
- Journal Title
  
  Am J Physiol Renal Physiol 297
  
  Pages: 679-684
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis(the STREAM study): evidence of safety and efficacy in a 5-year extension study.2009
- Author(s)
  Nishimoto N, Miyasaka N, Yamamloto K, Kawai S, Takeuchi T, Azumi J
- Journal Title
  
  Ann Rheum Dis 68
  
  Pages: 1580-1584
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Interactions among type I and type II interferon, tumor necrosis factor, and ^[○!R]-estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus2009
- Author(s)
  Lee H, Mima T, Sugino H, Aoki C, Hoshino-N.Y, Matsubara K, Nishimoto N
- Journal Title
  
  Arthritis Research & Therapy 11R1
  
  Pages: 1-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Laboratory and febrile features after joint surgery in rheumatoid arthritis patients treated with tocilizumab2009
- Author(s)
  Hirao M, Hashimoto J, Tsuboi H, Nampei A, Nakahara H, Yoshio N, Mima T, Yoshikawa H, Nishimoto N
- Journal Title
  
  Ann Rheum Dis 68
  
  Pages: 654-657
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] A case of peripheral neuropathy and skin ulcer in a patient with rheumatoid arthritis after a single infusion of tocilizumab2009
- Author(s)
  Sugiura F, Kojima T, Oguchi T, Urata S, Yuzawa Y, Sakakibara A, Hayashi H, Nishimoto N, Ishiguro N
- Journal Title
  
  Mod Rheumatol 19
  
  Pages: 199-203
- NAID
  10025112659
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Interaleukin-11 and paired immunoglobulin-like type 2 receptor alpha expression correlates with tha number of joints with active arthritis in systemic juvenile idiopathic arthritis.2009
- Author(s)
  Mima T, Ishikawa S, Aoki C, Yoshio-Hoshino N, Adachi Y, Imagawa T, Mori M, Tomiita M, Iwata N, Murata T, Miyoshi M, Takei S, Aihara Y, Yokota S, Matsubara K, Nishimoto N
- Journal Title
  
  Ann Rheum Dis 68
  
  Pages: 286-287
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Masked early symptoms of pneumonia in patients with rheumatoid arthritis during tocilizmab treatment : s report of two cases2009
- Author(s)
  Fujiwara H, Nishimoto N, Hamano Y, Asanuma N, Miki S, Kasayama S, Suemura M
- Journal Title
  
  Mod Rheumatol 19
  
  Pages: 64-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] A combination of biochemical markers of cartilage and bone turnover, radiographic damage and body mass index to predict the progression of joint destruction in patients with rheumatoid arthritis treated with disease-modifying anti-rheumatic drugs2009
- Author(s)
  Hashimoto J, Garnero P, van der Heijde D, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Yoshikawa H, Nishimoto N
- Journal Title
  
  Mod Rheumatol 19
  
  Pages: 273-282
- NAID
  10025112961
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Interactions among type I and II interferon, tumor necrosis factor, and beta-estradiol on the regulation of immune response-related gene expressions in systemic lupus erythematosus2009
- Author(s)
  Lee HM, Mima T, Sugino H, Aoki C, Adachi Y, Yoshio-Hoshino N, Matsubara K, Nishimoto N.
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 11(1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390299
[Journal Article] Responses of electromyogram activity in adductor longus muscle of rats to the altered gravity levels2008
- Author(s)
  Ohira, T., X. D. Wang, M. Terada, F. Kawano, Y. Higo, N. Nakai, T. Ochiai, J. Gyotoku, N. Nishimoto, A. Ogura, and Y. Ohira
- Journal Title
  
  J. Gravit. Physiol
  
  Volume: 15 Pages: 95-96
- Data Source
  KAKENHI-PROJECT-19100009
[Journal Article] Study of Active Controlled monotherapy Used for Rheumatoi Arthritis, an IL-6 inhibitor(SAMURAI) : -Evidence of clinica and radiographic benefit from an X-Ray Reader-Blinded Randomized Controlled Trial of Tocilizumab.2007
- Author(s)
  Nishimoto N, Hashimoto J, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, murata N, van der Heijde D, Kishimoto T
- Journal Title
  
  Ann rheum Dis (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Local biockade of IL-6R signaling induces lung CD4+T cell apoptosis in a murine model of asthma via regulatory T cells.2007
- Author(s)
  Fitto S, Eigenbrod T, Karwot R, Boross I, Doganci A, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Rose-John S, Galle PR, Neurath MF
- Journal Title
  
  Int Immunol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Establishment of a new interleukin-6(IL-6) receptor inhibitor applicable to the gene therapy for IL-6-dependent tumor2007
- Author(s)
  Yoshio-Hoshino N, Adachi Y, Aoki C, Pereboev A, Curiel DT, Nishimoto N.
- Journal Title
  
  Cancer Res 67
  
  Pages: 871-875
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Local biockade of IL-6R signaling induces lung CD4+T cell apoptosis in a murine model of asthma via regulatory T cells.2007
- Author(s)
  Fitto S, Eigenbrod T, Karwot R, Boross I, Doganci A, Ito.H, Nishimoto N, Yoshizaki K, Kishimoto T, Rose-John S, Galle PR, Neurath MF
- Journal Title
  
  Int Immunol (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Establishment of a new interleukin-6(IL-6) receptor inhibitor applicable to the gene therapy for IL-6-dependent tumor2007
- Author(s)
  Yoshio-Hoshino N, Adachi Y, Aoki C, Pereboev A, Curiel DT, Nishimoto N
- Journal Title
  
  Cancer Res 67
  
  Pages: 871-875
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Study of Active Controlled monotherapy Used for Rheumatoi Arthritis,an IL-6 inhibitor(SAMURAI) : -Evidence of clinica and radiographic benefit from an X-Ray Reader-Blinded Randomized Controlled Trial of Tocilizumab.2007
- Author(s)
  Nishimoto N, Hashimoto J, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, murata N, van der Heijde D, Kishimoto T
- Journal Title
  
  Ann rheum Dis (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Anti-interleukin-6 receptor antibody therapy in,rheumatic diseases.2006
- Author(s)
  Nakahara H, Nishimoto N
- Journal Title
  
  Endocr Metab Immune Disord Drug Targets. 6
  
  Pages: 373-381
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Interleukin-6 induces both cell growth and VEGF production in malignant mesotheliomas.2006
- Author(s)
  Adachi Y, Aoki C, Yoshio-Hoshino N, Takayama K, Curiel DT, Nishimoto N
- Journal Title
  
  Int J Cancer. 119
  
  Pages: 1303-1311
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Anti-interleukin-6 receptor antibody therapy favors adrenal androgen, secretion in patients with rheumatoid arthritis : arandomized double-blind placebo-controled study.2006
- Author(s)
  Straub RH, Harle P, Yamana S, Matsuda T, Takasugi K, Kishimoto T, Nishimoto N
- Journal Title
  
  ArthritisRheum 54
  
  Pages: 1778-1785
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Suppressor of Cytokine Signaling-1 (SOCS-1) Expression by Infectivity Enhanced Adenoviral Vector Inhibits IL-6 Dependent Proliferation of Multiple Myeloma Cells.2006
- Author(s)
  Yamamoto M, Nishimoto N, Davydova J, Kishimoto T, Curiel DT
- Journal Title
  
  Cancer Gene Ther 13
  
  Pages: 194-202
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Interleukin 6 : from bench to bedside.2006
- Author(s)
  Nishimoto N, Kishimoto T
- Journal Title
  
  Nat Clin Pract Rheumatol 2
  
  Pages: 619-626
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Interleukin-6 induces both cell growth and VEGF production in malignant mesotheliomas.2006
- Author(s)
  Adachi Y, Aoki C, Yoshio-Hoshino N, Takayama K, Curiel DT, Nishimoto N
- Journal Title
  
  Int J Cancer 119
  
  Pages: 1303-1311
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Suppressor of Cytokine Signaling-1 (SOCS-1) Expression by Infectivity Enhanced Adenoviral Vector Inhibits IL-6 Dependent Proliferation of Multiple Myeloma Cells.2006
- Author(s)
  Yamamoto M, Nishimoto N, Davydova J, Kishimoto T, Curiel DT
- Journal Title
  
  Cancer Gene Ther. 13
  
  Pages: 194-202
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Interleukin-6 in rheumatoid arthritis.2006
- Author(s)
  Nishimoto N.
- Journal Title
  
  Curr Opin Rheumatol 18
  
  Pages: 277-281
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Anti-interleukin-6 receptor antibody therapy in, rheumatic diseases.2006
- Author(s)
  Nakahara H, Nishimoto N
- Journal Title
  
  Endocr Metab Immune Disord Drug Targets 6
  
  Pages: 373-381
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Anti-interleukin-6 receptor antibody therapy in, rheumatic diseases.2006
- Author(s)
  Nakahara H, Nishimoto N.
- Journal Title
  
  Endocr Metab Immune Disord Drug Targets 6
  
  Pages: 373-381
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Interleukin 6 : from bench to bedside.2006
- Author(s)
  Nishimoto N, Kishimoto T.
- Journal Title
  
  Nat Clin Pract Rheumatol 2
  
  Pages: 619-626
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Interleukin-6 induces both cell growth and VEGF production in malignant mesotheliomas.2006
- Author(s)
  Adachi Y, Aoki C, Yoshio-Hoshino N, Takayama K, Curiel DT, Nishimoto N.
- Journal Title
  
  Int J Cancer. 119
  
  Pages: 1303-1311
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Anti-interleukin-6 receptor antibody therapy favors adrenal androgen, secretion in patients with rheumatoid arthritis : arandomized double-blind placebo-controled study.2006
- Author(s)
  Straub RH, Harle P, Yamana S, Matsuda T, Takasugi K, Kishimoto T, NishimotoN
- Journal Title
  
  ArthritisRheum 54
  
  Pages: 1778-1785
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Interleukin-6 in rheumatoid arthritis2006
- Author(s)
  Nishimoto N
- Journal Title
  
  Curr Opin Rheumatol 18
  
  Pages: 277-281
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman's disease.2005
- Author(s)
  Nishimoto N, Kanakura Y, Aozasa K, et al.
- Journal Title
  
  Blood 106
  
  Pages: 2627-2632
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Clinical study in patients with Castleman's desease, Crohn's disease and rheumatoid arthritis in Japan.2005
- Author(s)
  Nishimoto N.
- Journal Title
  
  Clin. Rev. in Allegy and Immunol. 28
  
  Pages: 221-230
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] The therapy of autoimmune diseases by anti-interleukin-6 receptor antibody2005
- Author(s)
  Mihara M, Nishimoto N, Ohsugi Y
- Journal Title
  
  Expert Opin. Biol. Ther. 5
  
  Pages: 683-690
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Clinical study in patients with Castleman's desease, Crohn's disease and rheumatoid arthritis in Japan.2005
- Author(s)
  Nishimoto N.
- Journal Title
  
  Clin.Rev.in Allegy and Immunol. 28
  
  Pages: 221-230
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] The therapy of autoimmune diseases by anti-interleukin-6 receptor antibody2005
- Author(s)
  Mihara M, Nishimoto N, Ohsugi Y.
- Journal Title
  
  Expert Opin.Biol.Ther. 5
  
  Pages: 683-690
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] The therapy of autoimmune diseases by anti-interleukin-6 receptor antibody2005
- Author(s)
  Mihara M, Nishimoto N, Ohsugi Y
- Journal Title
  
  Expert Opin.Biol.Ther. 5
  
  Pages: 683-690
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Suppressor of Cytokine Signaling^<-1> (SOCS-1) Expression by Infectivity Enhanced Adenoviral Vector Inhibits IL-6 Dependent Proliferation of Multiple Myeloma Cells.2005
- Author(s)
  Yamamoto M, Nishimoto N, Davydova J, et al.
- Journal Title
  
  Cancer Gene Ther. 13
  
  Pages: 194-202
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Imaging of lesions in a murine rheumatoid arthritis model with a humanized anti-interleukin-6 receptor antibody.2005
- Author(s)
  Sugimoto K, Nishimoto N, Kishimoto T, et al.
- Journal Title
  
  Ann Nucl Med. 19
  
  Pages: 261-266
- NAID
  10017671890
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Clinical study in patients with Castleman's desease, Crohn's disease and rheumatoid arthritis in Japan.2005
- Author(s)
  Nishimoto N
- Journal Title
  
  Clin.Rev. in Allegy and Immunol. 28
  
  Pages: 221-230
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Cytokine signal regulation and autoimmune disorders.2005
- Author(s)
  Nishimoto N.
- Journal Title
  
  Autoimmunity 38
  
  Pages: 359-367
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Suppressor of Cytokine Signaling-1(SOCS-1) Expression by Infectivity Enhanced Adenoviral Vector Inhibits IL-6 Dependent Proliferation of Multiple Myeloma Cells.2005
- Author(s)
  Yamamoto M, Nishimoto N, Davydova J, et al.
- Journal Title
  
  Cancer Gene Ther. 13
  
  Pages: 194-202
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Imaging of lesions in a murine rheumatoid arthritis model with a humanized anti-interleukin-6 receptor antibody.2005
- Author(s)
  Sugimoto K, Nishimoto N, Kishimoto T, et al.
- Journal Title
  
  Ann Nucl Med 19
  
  Pages: 261-266
- NAID
  10017671890
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Effect of anti-mouse interleukin-6 receptor antibody in autoimmune mouse models. In Monoclonal Antibodies Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman's disease.2005
- Author(s)
  Mihara M, Nishimoto N, Ohsugi Y
- Journal Title
  
  New Research(Edited by Simmons MA)(Nova Science Publishers, Inc.)
  
  Pages: 151-162
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Cytokine signal regulation and autoimmune disorders2005
- Author(s)
  Nishimoto N.
- Journal Title
  
  Autoimmunity 38
  
  Pages: 359-367
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Effect of anti-mouse interleukin-6 receptor antibody in autoimmune mouse models. In Monoclonal Antibodies Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman's disease.2005
- Author(s)
  Mihara M, Nishimoto N, Ohsugi Y.
- Journal Title
  
  New Research(Edited by Simmons MA.)(Nova Science Publishers, Inc.)
  
  Pages: 151-162
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Suppressor of Cytokine Signaling-1 (SOCS-1) Expression by Infectivity Enhanced Adenoviral Vector Inhibits IL-6 Dependent Proliferation of Multiple Myeloma Cells.2005
- Author(s)
  Yamamoto M, Nishimoto N, Davydova J, et al.
- Journal Title
  
  Cancer Gene Ther. 13
  
  Pages: 194-202
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Effect of anti-mouse interleukin-6 receptor antibody in autoimmune mouse models. In Monoclonal Antibodies Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman's disease.2005
- Author(s)
  Mihara M, Nishimoto N, Ohsugi Y
- Journal Title
  
  New Research (Inc. Edited by Simmons MA.)(Nova Science Publishers)
  
  Pages: 151-162
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390290
[Journal Article] Treatment of rheumatoid arthritis with humanized anti-interleukin 6 receptor antibody.2004
- Author(s)
  Nishimoto N, et al.
- Journal Title
  
  Arthritis Rheum. 50
  
  Pages: 1761-69
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370163
[Journal Article] Inhibition of IL-6 for the treatment of inflammatory diseases.2004
- Author(s)
  Nishimoto N, et al.
- Journal Title
  
  Curr Opin Pharmacol. (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370163
[Journal Article] Inhibition of IL-6 for the treatment of inflammatory diseases.2004
- Author(s)
  Nishimoto N, et al.
- Journal Title
  
  Curr Opin Pharmacol. 4
  
  Pages: 386-391
- Data Source
  KAKENHI-PROJECT-16043234
[Journal Article] Treatment of rheumatoid arthritis with humanized anti-interleukin 6 receptor antibody.2004
- Author(s)
  Nishimoto N, et al.
- Journal Title
  
  Arthritis Rheum. 50
  
  Pages: 1761-1769
- Data Source
  KAKENHI-PROJECT-16043234
[Journal Article] Toxicity, pharmacokinetics, and dose-finding study of repetitive treatment with the humanized anti-Interleukin 6 receptor antibody MRA in rheumatoid arthritis. Phase I/II clinical study.2003
- Author(s)
  Nishimoto N, et al.
- Journal Title
  
  J Rheumatol 30
  
  Pages: 1426-1435
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370163
[Journal Article] Toxicity, pharmacokinetics, and dose finding study of repetitive treatment with humanized anti-interleukin 6 receptor antibody, MRA, in rheumatoid arthritis -a phase I/II clinical study of MRA for rheumatoid arthritis in Japan2003
- Author(s)
  Nishimoto N, et al.
- Journal Title
  
  J Rheumatol. 30
  
  Pages: 1426-1435
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370163
[Journal Article] Cytokine signal regulation and autoimmune disorders.
- Author(s)
  Nishimoto N.
- Journal Title
  
  Autoimmune research in Japan (in press)
- Data Source
  KAKENHI-PROJECT-16043234
[Journal Article] Effects of mechanical over-loading on the properties of soleus muscle fibers, with or without damage, in wild type and mdx mice
- Author(s)
  Terada, M., F. Kawano, T. Ohira, N. Nakai, N. Nishimoto, and Y. Ohira
- Journal Title
  
  PLoS ONE
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-19100009
[Journal Article] Effects of mechanical over-loading on the properties of soleus muscle fibers, with or without damage, in wild type and mdx mice
- Author(s)
  Terada, M., F.Kawano, T.Ohira, N.Nakai, N.Nishimoto, Y.Ohira
- Journal Title
  
  PLoS ONE
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19100009
[Journal Article] Clinical study in patients with Castleman's disease, Crohn's disease and rheumatoid arthritis in Japan.
- Author(s)
  Nishimoto N.
- Journal Title
  
  Clin Rev In Allegy and Immunol. (in press)
- Data Source
  KAKENHI-PROJECT-16043234
[Presentation] 脊椎関節炎患者の血中IL-17値に対するTNF阻害治療による影響2019
- Author(s)
  村上美帆、西本憲弘
- Organizer
  日本脊椎関節炎学会　第29回学術集会
- Data Source
  KAKENHI-PROJECT-17K09984
[Presentation] IL-6阻害治療による関節リウマチ患者のCD25+CD4+活性化T細胞の割合の変化2016
- Author(s)
  村上美帆、栗谷太郎、西本憲弘
- Organizer
  第60回日本リウマチ学会総会・学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-25461481
[Presentation] IL-6 BLOCKADE WITH TOCILIZUMAB DOES NOT SUPPRESS CD4+T CELL ACTIVATION AT 48 WEEKS OF THE TREATMENT.2016
- Author(s)
  Miho Murakami, Taro Kuritani, Norihiro Nishimoto
- Organizer
  Annual European Congress of Rheumatology EULAR 2016
- Place of Presentation
  London, UK
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461481
[Presentation] Composition of dendritic cell and NK cell-related network with abnormally expressed glycosylation-related molecules in the bone marrow cells from patients with rheumatoid arthritis2015
- Author(s)
  M.N.Ito, M.Murakami, K.Ochi, Y.shimaoka, T.ochi, N.Nishimoto
- Organizer
  EULAR 2015
- Place of Presentation
  Rome,Italy
- Year and Date
  2015-06-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293236
[Presentation] 関節リウマチ患者骨髄おける糖鎖修飾異常の検討2015
- Author(s)
  伊藤眞里、村上美帆、越智健介、島岡康則、越智隆弘、西本憲弘
- Organizer
  第59回日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-26293236
[Presentation] 関節リウマチ患者特異的iPS細胞由来の単球は破骨分化能が高い2015
- Author(s)
  伊藤眞里、村上美帆、丹羽明、大澤光次郎、齊藤潤、中畑龍俊、西本憲弘
- Organizer
  第一回日本骨免疫学会
- Place of Presentation
  ホテルブリーズベイマリーナ（宮古島）
- Year and Date
  2015-06-30
- Data Source
  KAKENHI-PROJECT-26293236
[Presentation] Monocytes differentiated from iPS cells derived from rheumatoid arthritis patients express more m-scf-receptor together with rank than those from healthy donors resulting in the accelerated osteoclastgenesis2015
- Author(s)
  M.N.Ito, M.Murakami, M.Saito, A.Niwa, M.Osawa, T.Nakahata, N.Nishimoto.
- Organizer
  EULAR 2015
- Place of Presentation
  Rome,Italy
- Year and Date
  2015-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293236
[Presentation] 関節リウマチ（RA）患者iPS細胞を用いた破骨細胞分化系の構築と分化能の検討2015
- Author(s)
  伊藤眞里、村上美帆、西本憲弘
- Organizer
  第59回日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋国際会議場、愛知
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-26293236
[Presentation] 関節リウマチ患者由来iPS細胞から分化した単球は破骨細胞分化能が高い2015
- Author(s)
  伊藤眞里、村上美帆、丹羽明、大澤光次郎、齊藤潤、中畑龍俊、西本憲弘
- Organizer
  第36回日本炎症・再生医学会
- Place of Presentation
  虎ノ門ヒルズフォーラム
- Year and Date
  2015-07-21
- Data Source
  KAKENHI-PROJECT-26293236
[Presentation] RA患者由来iPS細胞を用いた単球系細胞分化におけるCD14+CD15+細胞の異常発現の検討2014
- Author(s)
  福家有子、村上美帆、伊藤眞里、西本憲弘
- Organizer
  第58回日本リウマチ学会総会・学術集会
- Place of Presentation
  グランドプリンス新高輪、東京
- Year and Date
  2014-04-24
- Data Source
  KAKENHI-PROJECT-26293236
[Presentation] 疾患iPS細胞を用いた破骨細胞分化系の構築と分化能の検討2014
- Author(s)
  伊藤眞里、村上美帆、丹羽明、齊藤潤、中畑龍俊、西本憲弘
- Organizer
  第1回日本骨免疫会議
- Place of Presentation
  万国津梁館、沖縄
- Year and Date
  2014-07-05
- Data Source
  KAKENHI-PROJECT-26293236
[Presentation] Abatacept treatment suppresses T CELL activation in anti-cyclic citrullinated peptide antibody (ACPA) positive RA patients but not in acpa negative RA patients.2013
- Author(s)
  T. Matsutani, M. Murakami, M. Sekiguchi, K. Matsui, M. Kitano, M. Namiki, K. Ohmura, Y. Imura, T. Fujii , T.Kuroiwa, H. Nakahara, S. Hika, K. Maeda, Y. Nozaki, M. Funauchi, K. Murakami, T. Ikawa, S. Irimajiri, A. Nampei, T. Azuma, T. Sasaki, A. Yokota, S. Morita, Y. Kawahito, T. Mimori, H. Sano, N. Nishimoto．
- Organizer
  EULAR 2013
- Place of Presentation
  Madrid. Spain
- Data Source
  KAKENHI-PROJECT-25461481
[Presentation] Changes in cytokine profiles in rheumatoid arthritis patients during abatacept treatment.2013
- Author(s)
  M. Murakami, T. Matsutani, M. Sekiguchi, K. Matsui, M. Kitano, M. Namiki, K. Ohmura, Y. Imura, T. Fujii, T. Kuroiwa, H. Nakahara, S. Higa, K. Maeda, Y. Nozaki, M. Funauchi, K. Murakami, T. Ikawa, S. Irimajiri, A. Nampei, T. Azuma, T. Sasaki, A. Yokota, S. Morita, Y. Kawahito, T. Mimori, H. Sano, N. Nishimoto.
- Organizer
  EULAR 2013
- Place of Presentation
  Madrid. Spain
- Data Source
  KAKENHI-PROJECT-25461481
[Presentation] 抗環状シトルリン化ペプチド抗体陽性RA患者におけるT細胞の活性化2013
- Author(s)
  村上美帆、松谷隆治、李穎、關口昌弘、松井聖、北野将康、大村浩一郎、井村嘉孝、藤井隆夫、黒岩孝則、中原英子、前田恵治、村上孝作、森田智視、川人豊、三森経世、佐野統、西本憲弘
- Organizer
  第57回日本リウマチ学会総会・学術集会．ポスター
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25461481
[Presentation] Comparison Of Pathological Features Of The Lung Lesions Of Systemic IgG4-Related Disease And Multicentric Castleman's Disease2013
- Author(s)
  Y. Terasaki, S. Ikushima, Y. Ichimura, M. Ujita, Y. Matsuzawa, M. Arita, K. Tomii, Y. Komase, I. Ohwan, T. Kawamura, S. Izumi, M. Murakami, H. Ishimoto, H. Kimura, M. Bando, N. Hada, N. Nishimoto, S. Matsui, T. Ogura.
- Organizer
  American Thoracic Society 2013
- Place of Presentation
  Philadelphia
- Data Source
  KAKENHI-PROJECT-25461481
[Presentation] 関節リウマチの治療　生物学的製剤(TNF阻害薬以外) アバタセプト治療は抗環状シトルリン化ペプチド抗体陽性RA患者の活性化T細胞を抑制する2013
- Author(s)
  松谷隆治、李頴、村上美帆、關口昌弘、松井聖、北野将康、大村浩一郎、井村嘉孝、藤井隆夫、黒岩孝則、中原英子、前田恵治、村上孝作、川人豊、三森経世、佐野統、西本憲弘
- Organizer
  第57回日本リウマチ学会総会・学術集会．口頭発表
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25461481
[Presentation] 抗環状シトルリン化ペプチド抗体陽性RA患者におけるT細胞の活性化2013
- Author(s)
  村上美帆、松谷隆治、李穎、關口昌弘、松井聖、北野将康、大村浩一郎、井村嘉孝、藤井隆夫、黒岩孝則、中原英子、前田恵治、村上孝作、川人豊、三森経世、佐野統、西本憲弘
- Organizer
  第57回日本リウマチ学会総会・学術集会
- Place of Presentation
  京都国際会館，京都
- Data Source
  KAKENHI-PROJECT-24591453
[Presentation] アバタセプト治療は抗環状シトルリン化ペプチド抗体陽性RA患者の活性化T細胞を抑制する2013
- Author(s)
  松谷隆治、村上美帆、李穎、關口昌弘、松井聖、北野将康、大村浩一郎、井村嘉孝、藤井隆夫、黒岩孝則、中原英子、前田恵治、村上孝作、川人豊、三森経世、佐野統、西本憲弘.
- Organizer
  第57回日本リウマチ学会総会・学術集会
- Place of Presentation
  京都国際会館，京都
- Data Source
  KAKENHI-PROJECT-24591453
[Presentation] Blocking of CD28 co-stimulation with CTLA -4-Ig did not alter the activation status of CD8+ T cells in patients with RA2012
- Author(s)
  Matsutani T, Li Ying, Murakami M, Fujii T， Kawahito Y Mimori T, Sano H, Nishimoto N
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸国際会議場，兵庫
- Data Source
  KAKENHI-PROJECT-24591453
[Presentation] 関節リウマチにおけるCTLA4-Ig共刺激シグナル阻害剤のCD8+ T細胞への影響2012
- Author(s)
  松谷隆治、李穎、村上美帆、關口昌弘、松井聖、北野将康、大村浩一郎、井村嘉孝、藤井隆夫、黒岩孝則、中原英子、前田恵治、船内正憲、村上孝作、入交重雄、森田智視、川人豊、三森経世、佐野統、西本憲弘
- Organizer
  第40回日本臨床免疫学会
- Place of Presentation
  京王プラザホテル，東京
- Data Source
  KAKENHI-PROJECT-24591453
[Presentation] 生物学的製剤未治療RA患者に対するアバタセプト（CTLA4-Ig）治療前後におけるT細胞サブセットの変化2012
- Author(s)
  松谷隆治，李穎，村上美帆，松井聖，關口昌弘，北野将康，村上孝作，藤井隆夫，大村浩一郎，前田恵治，中原英子，島岡康則，南平昭豪，入交重雄，松尾崇史，井村嘉孝，川人豊，三森経世，佐野統，西本憲弘
- Organizer
  日本リウマチ学会
- Place of Presentation
  高ノ輪プリンスホテル，東京
- Data Source
  KAKENHI-PROJECT-24591453
[Presentation] アバタセプト（CTLA4-Ig）はT細胞の活性化を抑制し、IL-6の産生とTh17細胞を低下させる2012
- Author(s)
  松谷隆治、李穎、村上美帆、李慧敏、青木千恵子、關口昌弘、松井聖、北野将康、大村浩一郎、村上孝作、藤井隆夫、黒岩孝則、中原英子、前田恵治、井村嘉孝、南平昭豪、川人豊、三森経世、佐野統、西本憲弘
- Organizer
  第33回日本炎症・再生医学会
- Place of Presentation
  ホテル日航福岡，福岡
- Data Source
  KAKENHI-PROJECT-24591453
[Presentation] Interleukin-6 as a therapeutictarget in locomotor disorders2011
- Author(s)
  Nishimoto N, Murakami M, Matsutani T, Hashimoto J, Takagi N
- Organizer
  Bio-Rheumatology International Congress (BRIC)2011-GARN Tokyo meeting
- Place of Presentation
  Chiba. Japan(招待講演)
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Comparisons of MHC class I molecule xpressions in bone marrow(BM) cells and peripheral blood cells(PBCS) of rheumatoid rthritis(RA).2011
- Author(s)
  Lee H, Sugino H, Aoki C, Adachi Y, Shimaoka Y, Ochi T, Nishimoto N.
- Organizer
  EULAR2011
- Place of Presentation
  London, United Kingdom
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Abnormal expressions of immune response-related genes in RA bone marrow cells2011
- Author(s)
  Lee H, Aoki C, Shimaoka Y, Ochi K, Ochi T, Nishimoto N
- Organizer
  Bio-Rheumatology International Congress (BRIC)2011-GAEN Tokyo meeting
- Place of Presentation
  Chiba. Japan(招待講演)
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] 実臨床におけるエタネルセプトの有効な使用法-ケーススタディ:迷った末の選択-2011
- Author(s)
  西本憲弘
- Organizer
  第55回日本リウマチ学会・学術総会
- Place of Presentation
  兵庫(招待講演)
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] わが国の成功例:抗IL-6受容体抗体、トシリズマブの基礎と臨床開発2011
- Author(s)
  川合眞一, 西本憲弘
- Organizer
  第28回日本医学会総会シンポジウム
- Place of Presentation
  (招待講演)(Web開催)
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Underrexpressions of mitochondrial-DNA encoded ATP synthesis-related genes and of DNA repair genes in systemic lupus erythematosus2011
- Author(s)
  Lee H, Sugino H, Aoki C, Adachi Y, Nishimoto N
- Organizer
  APLAR Symposium2011
- Place of Presentation
  Taipei.Taiwan
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Association between SLE patients with or without photosensitivity and the expression of mitochondrial encoded ATP synthesis-related and DNA repair genes2011
- Author(s)
  Lee H, Sugino H, Aoki C, Umegaki T, Furukawa F, Nishimoto N
- Organizer
  ACA2011
- Place of Presentation
  Suntec Singapore
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Abnormal expressions of immune response-related genes in RA bone marrow cells2011
- Author(s)
  Lee H, Aoki C, Shimaoka Y, Ochi K, Ochi T, Nishimoto N
- Organizer
  第55回日本リウマチ学会・学術総会
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Correlations between S100 gene expression levels and the local and systemic inflammatory markers(matrix metalloproteinase-3, MMP3 ; erythrocyte sedimentation rate, ESR) in rheumatoid arthritis patients2011
- Author(s)
  Lee H, Sugino H, Aoki C, Murakami M, Matsutani T, Ochi T, Nishimoto N.
- Organizer
  ACR2011
- Place of Presentation
  Chiago. USA
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Correlations between S100 gene expression levels and the local and systemic inflammatory markers (matrix metalloproteinase-3, MMP3 ; erythrocyte sedimentation rate, ESR) in rheumatoid arthritis patients2011
- Author(s)
  Lee H, Sugino H, Aoki C, Murakami M, Matsutani T, Ochi T, Nishimoto N
- Organizer
  ACR2011
- Place of Presentation
  Chicago. USA
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Suppression of interacellular s100A4 utilizing small interfering RNA inhibits osteoclast genesis2011
- Author(s)
  Sugino H, Lee H, Ochi T, Nishimoto N.
- Organizer
  EULAR2011
- Place of Presentation
  London, United Kingdom
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] 生物学的製剤の効果から見た成人のRAの炎症病態2011
- Author(s)
  西本憲弘
- Organizer
  第55回日本リウマチ学会・学術総会シンポジウム
- Place of Presentation
  兵庫(招待講演)
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Comparisons of MHC class I molecule xpressions in bone marrow(BM)cells and peripheral blood cells(PBCS) of rheumatoid arthritis(RA)2011
- Author(s)
  Lee H, Sugino H, Aoki C, Adachi Y, Shimaoka Y, Ochi T, Nishimoto N
- Organizer
  EULAE2011
- Place of Presentation
  London, United Kingdom
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] 炎症性免疫疾患に対するIL-6阻害治療-from bench to bedside-2011
- Author(s)
  西本憲弘
- Organizer
  第54回日本腎臓学会学術総会
- Place of Presentation
  横浜(招待講演)
- Year and Date
  2011-06-16
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] 関節リウマチに対する分子標的治療2011
- Author(s)
  西本憲弘
- Organizer
  第32回日本臨床薬学会年会
- Place of Presentation
  静岡(招待講演)
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Shortening of complemetarity determining region 3 of the T cell receptor α and β chains during thymocyte developmet2011
- Author(s)
  Matsutani T, Ogata M, Suzuki R, Ito T, Nishimoto N
- Organizer
  Immunolgy 2011
- Place of Presentation
  San Francisco, California. USA
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] 抗IL-6受容体抗体による炎症性免疫疾患の治療2011
- Author(s)
  西本憲弘
- Organizer
  第28回日本医学会総会シンポジウム
- Place of Presentation
  (招待講演)(Web開催)
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Subtoxic dose of mercury reducury reduces splenic marginal zone b cells, resulting in the increase in autoantibodies, in murine mercury-induced autoimmunity2011
- Author(s)
  Matsutani T, Murakami M, Lee H, Sugino H, Nishimoto N
- Organizer
  ACR2011
- Place of Presentation
  Chicago. USA
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] RA患者と関節炎を呈するDNasell KOマウスの骨髄における免疫機能異常の類似性2011
- Author(s)
  和田雅史, 李慧敏, 青木千恵子, 杉野英彦, 村上美帆, 松谷隆治, 越智隆弘, 西本憲弘
- Organizer
  第55回日本リウマチ学会・学術総会
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] 免疫内科における免疫抑制剤の使い方2011
- Author(s)
  西本憲弘
- Organizer
  第45回日本眼炎症学会
- Place of Presentation
  京都(招待講演)
- Year and Date
  2011-07-08
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] 破骨細胞形成におけるs100A4の機能解析2011
- Author(s)
  杉野英彦, 李慧敏, 青木千恵子, 和田雅史, 村上美帆, 松谷隆治, 越智隆弘, 西本憲弘
- Organizer
  第55回日本リウマチ学会・学術総会
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Blocking interleukin-6 signal ameliorates inflammatory manifestations and laboratories of cachexia in a patient with malignant mesothelioma : A case study2011
- Author(s)
  Murakami M, Matsutani T, Aoki C, Lee H, Li Y, Nishimoto N
- Organizer
  6^<th> International Cachexia Conference
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] The journey from IL-6 to Tocilizumab2011
- Author(s)
  西本憲弘
- Organizer
  第55回日本リウマチ学会・学術総会
- Place of Presentation
  兵庫(招待講演)
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] IL-6 and its role in autoimmunity2010
- Author(s)
  Nishimoto N
- Organizer
  Kitasato Symposium 2010-New Prospects for Cytokines-
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Professor Shibasaburo Kitasato der Donner2010
- Author(s)
  Nishimoto N
- Organizer
  Kitasato Symposium 2010-New Prospects for Cytokines-
- Place of Presentation
  Berlin, Germany
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] DNAチップによるSLEの遺伝子発現解析-光感受性遺伝子の発現異常2010
- Author(s)
  李慧敏, 杉野英彦, 安達康雄, 青木千恵子, 西本憲弘
- Organizer
  第54回日本リウマチ学会総会・学術集会ワークショップW1-D-2-3
- Place of Presentation
  神戸ポートピアホテル.兵庫
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Responsiveness to tocilizumab in rheumatoid arthritis patients is predicted by gene expression profile in peripheral blood cells at baseline.2010
- Author(s)
  Nishimoto N, Kawata Y, Aoki C
- Organizer
  The British Society for Rheumatology
- Place of Presentation
  Birmingham.United Kingdom
- Year and Date
  2010-04-22
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Rheumatoid arthritis patients with normal serum interleukin-6 levels can cease corticosteroid therapy without flare during tocilizumab therapy.2010
- Author(s)
  Tsuru T, Terao K, Suzuki M, Nakashima H, Akiyama A, Nishimoto N
- Organizer
  The British Society for Rheumatology
- Place of Presentation
  Birmingham.United Kingdom
- Year and Date
  2010-04-22
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] 全身型JIA患者におけるDNAチップを用いたトシリズマブの治療効果予測の可能性2010
- Author(s)
  西本憲弘, 河田祐一, 李慧敏, 青木千恵子, 安達康雄, 杉野英彦, 今川智之, 森雅亮, 冨板美奈子, 岩田直美, 村田卓士
- Organizer
  第54回日本リウマチ学会総会・学術集会ワークショップW-1-C-1
- Place of Presentation
  神戸ポートピアホテル.兵庫
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Drug-disease interaction study of tocilizumab in patients with rheumatoid arthritis -IL-6 signal inhibition normalized cytochrome P-450 enzymes expression which was reduced by inflammation2010
- Author(s)
  Terao K, Tsuru T, Suzaki M, Ishida Y, Amamoto T, Amamoto H, Higuchi S, Nishimoto N
- Organizer
  14^<th> APLAR2010
- Place of Presentation
  HongKong, China
- Year and Date
  2010-07-13
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Biology of IL-6 and its blockade in clinical practice.Hong Kong Convention and Exhibition Centre2010
- Author(s)
  Nishimoto N
- Organizer
  14^<th> APLAR2010
- Place of Presentation
  HongKong, China
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] トシリズマブ投与後の関節リウマチ患者の血清DKK1濃度の変化2010
- Author(s)
  南平昭豪, 平尾眞, 西本憲弘, 吉川秀樹, 橋本淳
- Organizer
  第54回日本リウマチ学会総会・学術集会ポスターセクションP-2-109
- Place of Presentation
  神戸ポートピアホテル.兵庫
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Drug-free Remission after cessation of Actemra Monotherapy(DREAM)2010
- Author(s)
  Nishimoto N
- Organizer
  Post EULAR Meeting 2010
- Place of Presentation
  Sao Paulo, Brazil
- Year and Date
  2010-07-28
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Abnormal Gene Expressions in the immune Response- and Cell Cycle-Networks of Bone Marrow Cells from Patients with Rheumatoid Arthritis as Revealed by DNA Microarray Analysis2010
- Author(s)
  Lee H, Sugino H, Aoki C, Adachi Y, Shimaoka Y, Ochi T, Nishimoto N
- Organizer
  Eular2010
- Place of Presentation
  Rome, Italy
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Up-regulation of hemophilic and heterophilic cell adhesion-related molecules in peripheral blood cells from patients with rheumatoid arthritis as revealed by DNA microarray analysis.2010
- Author(s)
  Lee H, Sugino H, Adachi Y, Aoki C.Nishimoto N
- Organizer
  14^<th> APLAR2010
- Place of Presentation
  HongKong, China
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] The Journey from IL-6 to tocilizumab2010
- Author(s)
  Nishimoto N
- Organizer
  Post EULAR Meeting 2010
- Place of Presentation
  Sao Paulo, Brazil
- Year and Date
  2010-07-28
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Drug-free Remission after cessation of Actemra Monotherapy(DREAM)2010
- Author(s)
  Nishimoto N
- Organizer
  American College of Rheumatology meeting 2010.
- Place of Presentation
  USA
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] 関節リウマチに対するトシリズマブ休薬後の効果持続期間の検討(DREAM試験)2010
- Author(s)
  西本憲弘
- Organizer
  第54回日本リウマチ学会総会・学術集会ワークショップW1-L-2
- Place of Presentation
  神戸ポートピアホテル.兵庫
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] TNF阻害薬不応例に対するトシリズマブの効果と問題点2010
- Author(s)
  西本憲弘
- Organizer
  第23回日本臨床リウマチ学会
- Place of Presentation
  東京ステーションコンファレンス東京
- Year and Date
  2010-11-28
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] トシリズマブ投与RA患者における呼吸器感染症についての検討2010
- Author(s)
  星大介, 設楽久美, 佐藤恵理, 北浜真理子, 瀬戸洋平, 浦野和子, 市川奈緒美, 小関由美, 谷口敦夫, 西本憲弘, 山中寿
- Organizer
  第54回日本リウマチ学会総会・学術集会.ワークショップW3-L-4-6
- Place of Presentation
  神戸ポートピアホテル.兵庫
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] 関節リウマチに対するIL-6阻害治療とDNAチップによる効果予測2010
- Author(s)
  西本憲弘
- Organizer
  第31回日本臨床薬理学会年会シンポジウム15分子標的薬とゲノムバイオマーカー
- Place of Presentation
  国立京都国際会館.京都
- Year and Date
  2010-12-03
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Drug free Remission after cessation of Actemra Monotherapy(The DREAM study)2010
- Author(s)
  Nishimoto N
- Organizer
  Eular2010 OPO134 A11 Abstract session : New biologics in clinical practice
- Place of Presentation
  Rome, Italy
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] DNA Microarray Analysis Revealed Overexpressions Of Cadherin And Protocadherin Families In Peripheral Blood Cells From Patients With Rheumatoid Arthritis (RA)2010
- Author(s)
  Lee H, Sugino H, Adachi Y, Aoki C, Nishimoto N
- Organizer
  Eular2010
- Place of Presentation
  Rome, Italy
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] RA患者における TCZ 休薬後の再燃に対する再投与の安全性と有効性(RESTORE試験)2010
- Author(s)
  西本憲弘
- Organizer
  第54回日本リウマチ学会総会・学術集会ワークショップW3-L-1
- Place of Presentation
  神戸ポートピアホテル.兵庫
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] リウマチ性疾患に対するIL-6レセプター抗体療法2010
- Author(s)
  西本憲弘
- Organizer
  第421回日本皮膚科学会大阪地方会第17回小林浩記念講演
- Place of Presentation
  朝日生命ホール.大阪
- Year and Date
  2010-09-18
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] 関節リウマチに対する抗体療法2010
- Author(s)
  西本憲弘
- Organizer
  第107回日本内科学会講演会シンポジウム「抗体療法の進捗と問題点
- Place of Presentation
  東京国際フォーラム東京
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] トシリズマブによるRAの治療(完結編)-ドラックフリーへの挑戦-2010
- Author(s)
  西本憲弘
- Organizer
  第54回日本リウマチ学会総会・学術集会セッション:最新治療セミナー
- Place of Presentation
  神戸ポートピアホテル.兵庫
- Year and Date
  2010-04-22
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Serum levels of Interleukin-6(IL-6) can be a good marker for capability of drug free remission in patients with rheumatoidarthritis treated by anti-IL-6 receptor antibody.2010
- Author(s)
  Nishimoto N
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Immune response to influenza vaccine in patients during the treatment with tocilizumab- comparison with conventional DMARDS and TNF inhibitors2010
- Author(s)
  Tsuru T, Terao K, Yoshio-Hoshio N, Suzaki M, Nakashima H, Akiyama-Michiyama A, Nishimoto N
- Organizer
  14^<th> APLAR2010
- Place of Presentation
  HongKong, China
- Year and Date
  2010-07-14
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] VEGF targeting in mesothelioma treatment using an interleukin-6 signal inhibitor based on adenovirus gene delivery2010
- Author(s)
  Adachi Y, Nishimoto N
- Organizer
  IMIG2010
- Place of Presentation
  Kobe, Japan
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] DNA microarray analysis revealed mitochondrial dysfunction and underexpressions of excision repair cross-complementing genes in peripheral blood cells from patients with systemic lupus erythematosus2010
- Author(s)
  Lee H, Sugino H, Aoki C, Adachi Y, Nishimoto N
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] 関節リウマチに対するIL-6阻害治療から学んだ骨代謝におけるIL-6の役割2010
- Author(s)
  西本憲弘, 橋本淳
- Organizer
  第28回日本骨代謝学会学術集会シンポジウム4
- Place of Presentation
  京王プラザホテル.東京
- Year and Date
  2010-07-21
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Retreatment Efficacy and Safety of Tocilizumab in patients with rheumatoidarthritis at Recurrence(RESTORE study)2010
- Author(s)
  Nishimoto N
- Organizer
  Eular2010
- Place of Presentation
  Rome, Italy
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] GWASから得られた関節リウマチ感受性遺伝子のDNAマイクロアレイによる発現検討2010
- Author(s)
  杉野英彦, 李慧敏, 安達康雄, 青木千恵子, 西本憲弘
- Organizer
  第54回日本リウマチ学会総会・学術集会ワークショップW3-F-1-5
- Place of Presentation
  神戸ポートピアホテル.兵庫
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Anti-IL6 receptor antibody therapy for autoimmune and malignant diseases2009
- Author(s)
  西本憲弘
- Organizer
  UAB Gene Therapy Seminar Series
- Place of Presentation
  Alabama, USA
- Year and Date
  2009-06-16
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] トシリズマブのTNF阻害剤抵抗性関節リウマチに対する第III相試験-有効性と安全性ならびにIL-6阻害によるIL-17の変化2009
- Author(s)
  美馬亨, 西本憲弘
- Organizer
  第53回日本リウマチ学会ワークショップW23-1
- Place of Presentation
  グランドプリンスホテル新高輪.東京
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] The IL-6 inhibition with tocilizumab in RA and Castleman's disease2009
- Author(s)
  西本憲弘
- Organizer
  Post EULAR Meeting 2009
- Place of Presentation
  Sao Paulo, Brazil
- Year and Date
  2009-08-28
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] RAの関節破壊におけるIL-6の重要性2009
- Author(s)
  西本憲弘
- Organizer
  第53回日本リウマチ学会総会・学術集会シンポジウムサテライトシンポジウムサイトカインネットワークと関節破壊-何を目指すべきか- SLS5-1
- Place of Presentation
  グランドプリンスホテル新高輪.東京
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Tumor Necrosis Factor(TNF)Emerged as A Dominant Cytokine in Peripheral Blood Immunoregulatory Network of Lupus Nephritis Patient after Treatment.2009
- Author(s)
  Lee H, Mima T, Sugino H, Aoki C, Nishimoto N.
- Organizer
  EULAR2009
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2009-06-11
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] RA患者に対するトシリズマブの治療効果はDNAチップを用いて予測可能である2009
- Author(s)
  西本憲弘, 美馬亨, 川田祐一
- Organizer
  第53回日本リウマチ学会ワークショップトシリズマブW23-3
- Place of Presentation
  グランドプリンスホテル新高輪.東京
- Year and Date
  2009-04-25
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Up-regulation of hemophilic cell adhesion-related molecules in peripheral blood may contribute to patho-genesis of rheumatoid arthritis(RA)2009
- Author(s)
  李慧敏, 杉野英彦, 安達康雄, 青木千恵子, 西本憲弘
- Organizer
  第37回日本臨床免疫学会 2-20
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] DNA Microarray Analysis Revealed Abnormal Networks of Immune Response Molecules in Bone Marrow Cells from Patients with Rheumayoid Arthtitis(RA)2009
- Author(s)
  Lee H, Sugino H, Adachi Y, Ochi T, Nishimoto N
- Organizer
  ACR/ARHP2009
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Normalisation In Serum IL-6 Levels Is A Good Biomarker For The Patients Who Can Cease The Corticosteroid Without Flare During IL-6 Receptor Inhibition Therapy Whth Tocilizumab2009
- Author(s)
  Tsuru T, Terao K, Suzuki M, Nakashima H, Akiyama A, Nishimoto N
- Organizer
  EULAR2009
- Place of Presentation
  Copenhagen, Denmark
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] 関節リウマチに対するIL-6阻害治療の効果発現メカリズムと効果予測2009
- Author(s)
  西本憲弘
- Organizer
  第53回日本リウマチ学会総会・学術集会サテライトシンポジウムS-1
- Place of Presentation
  グランドプリンスホテル新高輪国際館パミール.東京
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] The peripheral blood genes that account for predictability of clinical response to tocilizumab(TCZ)treatment, corticosteroid dose reduction, and serum IL-6 normalization at week 48 on systemic onset juvenile arthriris(sJIA)2009
- Author(s)
  Nishimoto N, Kawata Y, Lee H, Aoki C, Sugino H, Imagawa T, Mori M, Tomiita M, Murata T, Miyoshi M, Takei S, Aihara Y, Ochi T, Yokota S
- Organizer
  ACR/ARHP2009
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Experience with Mycobacterium tuberculosis Infection Reported in the Tocilizumab Worldwide RA Safety Database.2009
- Author(s)
  Van Vollenhoven RF, Nishimoto N, Yamanaka H, Woodworth T, Schiff MH, Taylor A, Pope JE
- Organizer
  EULAR2009
- Place of Presentation
  Copenhagen, Denmark
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Aberrant cytokine networks and metabolisms in patients with systemic onset and polyarticular type juvenile idiopathic arthritis(sJIA and pJIA)2009
- Author(s)
  西本憲弘
- Organizer
  第37回日本免疫学会・学術集会 S3-6
- Place of Presentation
  大阪国際会議場.大阪
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Gene expression profiling of S100 protein families in the peripheral blood from patients with RA, SLE, polyJIA and sJIA-correlation between S100A4 expression and jpint destruction2009
- Author(s)
  Nishimoto N, Sugino H, Aoki C, Lee H, Matsubara K, Mima T
- Organizer
  EULAR 2009
- Place of Presentation
  Copenhagen. Denmark
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] DNAチップによるSLEの遺伝子発現解析-ルーブス腎炎に対するエンドキサン大量療法により、インターフェロンによって誘導される遺伝子発現は低下した2009
- Author(s)
  李慧敏, 美馬亨, 杉野英彦, 安達康雄, 青木千恵子, 西本憲弘
- Organizer
  第53回日本リウマチ学会ポスターセクションP2-257
- Place of Presentation
  グランドプリンスホテル新高輪.東京
- Year and Date
  2009-04-24
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Gene expression profiling of S100 protein families in the peripheral blood from patients with RA, SLE, polyJIA and sJIA-correlation between S100A4 expression and joint destruction-2009
- Author(s)
  Nishimoto N, Sugino H, Aoki C, Lee H, Matsubara K, Mima T.
- Organizer
  EULAR2009
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] About half of S100 cluster genes on chromosome 1q21.1 are up-regulated in patients with rheumatoid arthritis(RA), systemic lupus erythematosus(SLE), polyarticular type juvenile idiopathic2009
- Author(s)
  Sugino H, Aoki C, Lee H, Adachi Y, Matsubara K, Ochi T, Nishimoto N
- Organizer
  ACR/ARHP2009
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Gene expression profile in peripheral blood cells at baseline predicts tocilizumab responsiveness of patients with rheumatoid arthritis.2009
- Author(s)
  Nishimoto N., Kawata Y., Aoki C., Mima T
- Organizer
  EULAR2009
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Are the responses of adductor longus muscle to gravitational unloading in Wistar Hannover rats region-specific?2007
- Author(s)
  Ohira, T., X.D. Wang, M. Terada, F. Kawano, Y. Higo, N. Nakai, T. Ochiai, J. Gyotoku, N. Nishimoto, and Y. Ohira
- Organizer
  23rd Annual Meet. of Am. Soc. Gravit. Space Biol.
- Place of Presentation
  Moffett Field, Ca., U.S.A.
- Year and Date
  2007-10-26
- Data Source
  KAKENHI-PROJECT-19100009
[Presentation] Responses of protein expression to cardiotoxin-induced muscle injury.2007
- Author(s)
  Kawano, F., M. Terada, N. Nakai, T. Ohira, Y. Higo, N. Nishimoto, and Y. Ohira.
- Organizer
  23rd Annual Meet. of Am. Soc. Gravit. Space Biol.
- Place of Presentation
  Moffett Field, Ca., U.S.A.
- Year and Date
  2007-10-27
- Data Source
  KAKENHI-PROJECT-19100009
[Presentation] ApoE欠損マウスの腎障害におけるインターロキシン6受容体阻害の効果
- Author(s)
  華山真理, 楽木宏実, 美馬亨, 安達康雄, 勝谷友宏, 小原政治, 青笹克之, 萩原俊男, 西本憲弘
- Organizer
  第32回日本高血圧学会総会
- Place of Presentation
  大津プリンスホテル.滋賀
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] Appearance of CD14+CD15+ poplulation during the differentiation from RA-iPS cells into monocytes
- Author(s)
  N.Nishimoto,M.Murakami, M.N.Ito, M.Saito, A. Niwa, T.Nakahata
- Organizer
  EULAR 2014
- Place of Presentation
  Paris, France
- Year and Date
  2014-06-11 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-26293236
[Presentation] T CELL CD80/CD86 CO-STIMULATORY BLOCKADE DOES NOT SUPPRESS CD8 (+) SUBPOPULATION IN THE COURSE OF 48-WEEK TREATMENT OF PATIENTS WITH RHEUMATOID ARTHRITIS
- Author(s)
  Miho Murakami, Mari Ito, Masahiro Sekiguchi, Kiyoshi Matsui, Masayasu Kitano, Yoshitaka Imura, Koichiro Ohmura, 4Takao Fujii, Takanori Kuroiwa, Keiji Maeda, Satoshi Morita, Yutaka Kawahito, Tsuneyo Mimori, Hajime Sano, Norihiro Nishimoto
- Organizer
  EULAR2014
- Place of Presentation
  Paris, France
- Year and Date
  2014-06-11 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-25461481
[Presentation] The peripheral blood genes that account for predictability of clinical response to tocilizumab(TCZ) treatment, corticosteroid dose reduction, and serum IL-6 normalization at week 48 on systemic onset juvenile arthriris(sJIA)
- Author(s)
  Nishimoto N, Kawata Y, Lee H, Aoki C, Sugino H, Imagawa T, Mori M, Tomiita M, Murata T, Miyoshi M, Takei S, Aihara Y, Ochi T, Yokota S
- Organizer
  ACR/ARHP2009
- Place of Presentation
  USA
- Data Source
  KAKENHI-PROJECT-21390299
[Presentation] RA患者に対するT 細胞共刺激シグナル抑制治療は抗環状シトルリン化ペプチド抗体価を下げない
- Author(s)
  村上美帆、伊藤眞里、福家有子、關口昌弘、松井聖、北野将康、井村嘉孝、大村浩一郎、藤井隆夫、黒岩孝則、前田恵治、川人豊、三森経世、佐野統、西本憲弘,
- Organizer
  第５７回日本リウマチ学会総会・学術集会
- Place of Presentation
  グランドプリンス新高輪、東京
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-25461481
[Presentation] T CELL CD80/CD86 CO-STIMULATORY BLOCKADE EFFECTIVELY SUPPRESSES CD25 (+) IN CD4 (+) T CELL SUBPOPULATION BUT NOT THE ACPA TITERS IN THE COURSE OF 48-WEEK TREATMENT OF PATIENTS WITH RHEUMATOID ARTHRITIS
- Author(s)
  Miho Murakami, Mari Ito, Masahiro Sekiguchi, Kiyoshi Matsui, Masayasu Kitano, Yoshitaka Imura, Koichiro Ohmura, 4Takao Fujii, Takanori Kuroiwa, Keiji Maeda, Satoshi Morita, Yutaka Kawahito, Tsuneyo Mimori, Hajime Sano, Norihiro Nishimoto
- Organizer
  EULAR2014
- Place of Presentation
  Paris, France
- Year and Date
  2014-06-11 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-25461481
[Presentation] RA 患者に対するT 細胞共刺激シグナル抑制治療はCD8 陽性サブセットには影響しない
- Author(s)
  伊藤眞里、村上美帆、福家有子、關口昌弘、松井聖、北野将康、井村嘉孝、大村浩一郎、藤井隆夫、黒岩孝則、前田恵治、川人豊、三森経世、佐野統、西本憲弘,
- Organizer
  第５７回日本リウマチ学会総会・学術集会
- Place of Presentation
  グランドプリンス新高輪、東京
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-25461481

1. YOSHIZAKI Kazuyuki (90144485)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
2. MURAKAMI Miho (30595591)

# of Collaborated Projects: 5 results

# of Collaborated Products: 52 results
3. MATSUMOTO Tomoshige (10311763)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. MATSUTANI Takaji (70372290)

# of Collaborated Projects: 4 results

# of Collaborated Products: 25 results
5. SUGINO Hidehiko (70270577)

# of Collaborated Projects: 3 results

# of Collaborated Products: 38 results
6. OCHI Takahiro (80112035)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. SUGIMURA Kazuhisa (80127240)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. MIMA Touru (30373517)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. NAKATA Ken (00283747)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 嶋良仁

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. OHIRA Yoshinobu (50185378)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
12. NAKAI Naoya (90324508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
13. KAWANO Fuminori (90346156)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
14. SAKODA Saburou (00178625)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. OHMI Shinobu (20160046)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. ADACHI Yasuo (10253882)

# of Collaborated Projects: 1 results

# of Collaborated Products: 24 results
17. MATSUMOTO Seiji (60412011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. HASEGAWA Seiki (10252438)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. KONDOU Nobuyuki (50402889)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. TAKUWA Teruhisa (00412049)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. KURODA Ayumi (90642570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. YOKOTA Syunnpei (10158363)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 横田章 (40222385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 桑島正道 (00205262)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 渡邊大 (10372624)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 古川福実 (40156964)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 名井陽 (10263261)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 前達雄 (10569734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 中村憲正 (50273719)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 北圭介 (30588869)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 大類隼人 (50594743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 斎藤潤 (90535486)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
33. 辻成佳 (30795761)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 橋本淳 (40237938)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 乾重樹 (30324750)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. KUBAGAWA Hiromi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. ANDERSON Ken

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. ANDERSON Kenneth C.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. KUBAGAWA HIi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 岡田随象

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

NISHIMOTO Norihiro 西本 憲弘

西本 憲弘 ニシモト ノリヒロ

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Elucidation of differentiation and function abnormalities of bone marrow mesenchymal cells using human induced pluripotent stem cell cells derived from patients with rheumatoid arthritis.Principal Investigator

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Study of pathogenic mechanism of autoimmune diseases using the evidence from anti-IL-6 therapyPrincipal Investigator

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Establishment of the anti-IL-6 receptor therapy for refractory autoimmune diseasesPrincipal Investigator

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免疫情報シグナル制御による免疫監視異常の修復Principal Investigator

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Research of molecular biology and gene therapy for Rheumatoid arthritis by regulation of IL-6 signal transductionPrincipal Investigator

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IL-6シグナル制御による慢性関節リウマチの分子・遺伝子治療の研究Principal Investigator

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NISHIMOTO Norihiro 西本憲弘

西本憲弘ニシモトノリヒロ