Nakayama Shu-ichi 中山周一

… Alternative Names

中山周一ナカヤマシユウイチ

NAKAYAMA Shu-ichi 中山周一

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Researcher Number	80280767
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所細菌第一部, 主任研究員
Affiliation (based on the past Project Information) *help	2018 – 2023: 国立感染症研究所, 細菌第一部, 主任研究官 2007: National Institute of Infectious Diseases, Dep. of Bacteriology, Principle investigator 2006: 国立感染症研究所, 主任研究官 1999 – 2000: 国立感染症研究所, 細菌部, 主任研究官 1996: 国立予防衛生研究所, 細菌部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 56030:Urology-related / Bacteriology (including Mycology) Except Principal Investigator Basic Section 49050:Bacteriology-related / Basic Section 54030:Infectious disease medicine-related / Bacteriology (including Mycology)
Keywords	Principal Investigator ゲノム多様性 / 梅毒トレポネーマ / 細胞侵入 / 系統細分化 / 簡便系統分類法 / 全ゲノム解析 / 感染経路推定 / ゲノム解析とその代替法 / ゲノム補完SNPs / 系統 … More / 梅毒 / 感染ルート推定 / 系統分類 / 分子型別改良 / 流行型把握 / 患者性指向 / 全ゲノム情報 / 分子型別 / 疫学 / 国内株初のトレポネーマ全ゲノム解析 / 近縁系統株を細分可能なSNP / MSMとheterosexuals / 詳細な菌株系統解析 / 近縁株を細分化できる１塩基置換候補 / cpxA / cpxR / 発現制御 / サルモネラ / リン酸化 / DNA結合能 / CpxR-CpxA / 2コンポーネント regulatory system / virF / 赤痢 … More Except Principal Investigator 自然形質転換 / セフトリアキソン / 薬剤耐性 / 形質転換 / 淋菌 / PNA / マクロライド系薬耐性 / PNA-LAMP法 / 梅毒 / PNAプローブ / マクロライド耐性 / peptide nucleic acid / LAMP / 23S rRNA / マクロライド / 梅毒トレポネーマ / competitive growth inhibition / urinary tract infection / extra-intestinal pathogenic Escherichia coli / pathogenic bacteria / 大腸菌 / PFGE / 競争的排除 / 病原性大腸菌 / 競争阻害 / 尿路感染症 / 腸管外病原性大腸菌 / 病原細菌 Less

Evaluation and application of putative SNPs that can define the lineages of T.pallidumPrincipal Investigator
- Principal Investigator
  
  Nakayama Shu-ichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  National Institute of Infectious Diseases
Development of detection procedure for macrolide-resistant Treponema pallidum with peptide nucleic acid-mediated loop-mediated isothermal amplification assay
- Principal Investigator
  
  Tarumoto Norihito
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Saitama Medical University
Systematic re-estimation of polymorphism of T. pallidum genome from wider range of specimens including T. p DNA of lower copy numbersPrincipal Investigator
- Principal Investigator
  
  Nakayama Shu-ichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  National Institute of Infectious Diseases
Origin of drug resistant gene of Neisseria gonorrhoeae.
- Principal Investigator
  
  Ohnishi Makoto
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  National Institute of Infectious Diseases
Model for evaluation of pathogenicity of extra-intestinal pathogenic Escherichia coli
- Principal Investigator
  
  OHNISHI Makoto
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  National Institute of Infectious Diseases
サルモネラcpxR-A遺伝子の宿主細胞侵入能及び病原性への関与の検討Principal Investigator
- Principal Investigator
  
  中山周一
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  National Institute of Infectious Diseases
赤痢菌virF遺伝子のcpxA-R2コンポーネント制御系による発現制御の研究Principal Investigator
- Principal Investigator
  
  中山周一
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  国立予防衛生研究所

All 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] High-throughput nanopore sequencing of Treponema pallidum tandem repeat genes arp and tp0470 reveals clade-specific patterns and recapitulates global whole genome phylogeny.2022
- Author(s)
  Nicole AP Lieberman, et al. Shu-ichi Nakayama, Kenichi Lee, Makoto Ohnishi, et al.
- Journal Title
  
  Front. Microbiol.
  
  Volume: 13 Pages: 1007056-1007056
- DOI
  10.3389/fmicb.2022.1007056
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09388
[Journal Article] Phylogenetic and Genetic Characterization of Treponema pallidum Strains from Syphilis Patients in Japan by Whole-genome Sequence Analysis from Global Perspectives.2021
- Author(s)
  Nishiki, S., Lee, K., Kanai, M., Nakayama, S., and Ohnishi, M.
- Journal Title
  
  Sci. Rep.
  
  Volume: 11 Issue: 1 Pages: 3154-3154
- DOI
  10.1038/s41598-021-82337-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09184
[Journal Article] Genome Sequencing of 196 Treponema pallidum strains from six continents reveals additional variability in vaccine candidate genes and dominance of Nichols clade strains in Madagascar.2021
- Author(s)
  Nicole A.P. Lieberman, Michelle J. Lin, Hong Xie, Lasata Shrestha, Tien Nguyen, Meei-Li Huang, Austin M. Haynes, Emily Romeis, Qian-Qiu Wang, Rui-Li Zhang, Cai-Xia Kou, Giulia Ciccarese, Ivano Dal Conte, Marco Cusini, Francesco Drago, Shu-ichi Nakayama, et al.
- Journal Title
  
  PLos Negl. Trop. Dis.
  
  Volume: 15
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09388
[Journal Article] Emergence and evolution of antimicrobial resistance genes and mutations in Neisseria gonorrhoeae2021
- Author(s)
  Yahara Koji、Ma Kevin C.、Mortimer Tatum D.、Shimuta Ken、Nakayama Shu-ichi、Hirabayashi Aki、Suzuki Masato、Jinnai Michio、Ohya Hitomi、Kuroki Toshiro、Watanabe Yuko、Yasuda Mitsuru、Deguchi Takashi、Eldholm Vegard、Harrison Odile B.、Maiden Martin C. J.、Grad Yonatan H.、Ohnishi Makoto
- Journal Title
  
  Genome Medicine
  
  Volume: 13 Issue: 1 Pages: 1-12
- DOI
  10.1186/s13073-021-00860-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07509, KAKENHI-PROJECT-18K17406, KAKENHI-PROJECT-18H02659
[Journal Article] Epidemiology, Molecular Strain Types, and Macrolide Resistance of Treponema pallidum in Japan, 2017-2018.2020
- Author(s)
  Nishiki, S., Arima, Y., Kanai, M., Shimuta, K., Nakayama, S., and Ohnishi
- Journal Title
  
  J. Infect. Chemother.
  
  Volume: 26 Issue: 10 Pages: 1042-1047
- DOI
  10.1016/j.jiac.2020.05.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09184
[Journal Article] A novel peptide nucleic acid- and loop-mediated isothermal amplification assay for the detection of mutations in the 23S rRNA gene of Treponema pallidum2020
- Author(s)
  Tarumoto Norihito、Imai Kazuo、Nakayama Shu-ichi、Itoda Ichiro、Sakai Jun、Murakami Takashi、Maesaki Shigefumi、Hayakawa Satoshi、Ohnishi Makoto、Maeda Takuya
- Journal Title
  
  Journal of Medical Microbiology
  
  Volume: 69 Issue: 12 Pages: 1339-1345
- DOI
  10.1099/jmm.0.001275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08446, KAKENHI-PROJECT-18K09184
[Journal Article] Characterization of two Neisseria gonorrhoeae strains with high-level azithromycin resistance isolated in 2015 and 2018 in Japan2020
- Author(s)
  Shimuta Ken、Lee Kenichi、Yasuda Mitsuru、Furubayashi Keiichi、Uchida Chiaki、Nakayama Shu-ichi、Takahashi Hideyuki、Ohnishi Makoto
- Journal Title
  
  Sexually Transmitted Diseases
  
  Volume: Publish Ahead of Print Issue: 7 Pages: 1-5
- DOI
  10.1097/olq.0000000000001303
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09163, KAKENHI-PROJECT-19K07550, KAKENHI-PROJECT-18H02659
[Journal Article] Infective endocarditis due to Treponema pallidum: A case diagnosed by polymerase chain reaction analysis of aortic valve.2019
- Author(s)
  Hijikata, S., Hongo, I., Nakayama, S., Yamaguchi, T., Sekikawa, Y., and Nozato, T.
- Journal Title
  
  Canadian Journal of Cardiology.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09184
[Journal Article] A Real-Time PCR Assay for the Detection of a penA Mutation Associated with Ceftriaxone Resistance in Neisseria gonorrhoeae.2019
- Author(s)
  Shimuta K, Igawa G, Yasuda M, Deguchi T, Nakayama SI, Ohnishi M.
- Journal Title
  
  J Glob Antimicrob Resist
  
  Volume: in press Pages: 46-49
- DOI
  10.1016/j.jgar.2019.02.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11061, KAKENHI-PROJECT-18K09163, KAKENHI-PROJECT-18H02659
[Journal Article] A Loop-Mediated Isothermal Amplification Assay Targeting Neisseria Gonorrhoeae penA-60.0012019
- Author(s)
  Ken Shimuta, Shu-Ichi Nakayama, Hideyuki Takahashi, Makoto Ohnishi
- Journal Title
  
  Antimicrob Agents Chemother .
  
  Volume: 64 Issue: 1
- DOI
  10.1128/aac.01663-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07550, KAKENHI-PROJECT-18H02659, KAKENHI-PROJECT-16K11061
[Journal Article] Molecular typing and macrolide resistance analyses of Treponema pallidum in heterosexuals and men who have sex with men in Japan, 2017.2019
- Author(s)
  Kanai, M., Arima, Y., Nishiki, S., Shimuta, K., Itoda, I., Matsui, T., Oishi, K., Ohnishi, M, and Nakayama, S.
- Journal Title
  
  J. Clin. Microbiol.
  
  Volume: 57 Issue: 1
- DOI
  10.1128/jcm.01167-18
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09184
[Journal Article] Clonal expansion and spread of the ceftriaxone-resistant Neisseria gonorrhoeae strain FC428, identified in Japan in 2015, and closely related isolates2019
- Author(s)
  203)Lee K, Nakayama SI, Osawa K, Yoshida H, Arakawa S, Furubayashi KI, Kameoka H, Shimuta K, Kawahata T, Unemo M, Ohnishi M.
- Journal Title
  
  J Antimicrob Chemother
  
  Volume: 74 Issue: 7 Pages: 1812-1819
- DOI
  10.1093/jac/dkz129
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02659, KAKENHI-PROJECT-18H03046, KAKENHI-PROJECT-16K11061
[Journal Article] Cerebral Syphilitic Gumma can arise within months of reinfection: a case of histologically proven Treponema pallidum Strain Type 14b/f infection with Human Immunodeficiency Virus positivity.2018
- Author(s)
  Y. Koizumi, T. Watabe, Y. Ota, S. Nakayama, N. Asai, M. Hagihara, Y. Yamagishi, H. Suematsu, T. Tsuzuki, M. Takayasu, M. Ohnishi, and H. Mikamo.
- Journal Title
  
  Sex Transm. Dis.
  
  Volume: 45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09184
[Journal Article] Genomic surveillance of Neisseria gonorrhoeae to investigate the distribution and evolution of antimicrobial-resistance determinants and lineages2018
- Author(s)
  Yahara Koji、Nakayama Shu-ichi、Shimuta Ken、Lee Ken-ichi、Morita Masatomo、Kawahata Takuya、Kuroki Toshiro、Watanabe Yuko、Ohya Hitomi、Yasuda Mitsuru、Deguchi Takashi、Didelot Xavier、Ohnishi Makoto
- Journal Title
  
  Microbial Genomics
  
  Volume: 4 Issue: 8 Pages: 1-13
- DOI
  10.1099/mgen.0.000205
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11061, KAKENHI-PROJECT-18K09163, KAKENHI-PROJECT-18K09184, KAKENHI-PROJECT-18K17406, KAKENHI-PROJECT-18H02659, KAKENHI-PROJECT-18H03046
[Journal Article] Neisseria cinerea with high ceftriaxone MIC is a source of ceftriaxone and cefixime resistance-mediating penA sequences in Neisseria gonorrhoeae.2018
- Author(s)
  Igawa, G., Yamagishi, Y., Dorin, M., Shimuta, K., Suematsu, H., Nakayama, S., Mikamo, H., Unemo, M., and Ohnishi, M.
- Journal Title
  
  Antimicrob. Agents Chemother.
  
  Volume: 62
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09184
[Presentation] 梅毒：迅速診断の展望とゲノム解析結果から見える国内株の系統位置2022
- Author(s)
  中山周一
- Organizer
  第36回日本エイズ学会学術集会・総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K09388
[Presentation] 淋菌penA 60.001遺伝子のLAMP法による検出2019
- Author(s)
  志牟田　健、中山周一、高橋英之、大西真
- Organizer
  日本性感染症学会第32回学術大会
- Data Source
  KAKENHI-PROJECT-18H02659
[Presentation] PNA-LAMP法を用いたマクロライド耐性梅毒トレポネーマの検出に関する検討2019
- Author(s)
  樽本憲人、前崎繁文、前田拓哉、中山周一、大西　真、早川　智、井戸田一朗
- Organizer
  日本性感染症学会第31回学術大会
- Data Source
  KAKENHI-PROJECT-18K09184
[Presentation] PNA-LAMP法を用いたマクロライド耐性梅毒トレポネーマの検出に関する検討2019
- Author(s)
  樽本憲人、中山周一、井戸田一朗、前﨑繁文、早川智、大西真、前田卓哉
- Organizer
  日本性感染症学会第32回学術大会
- Data Source
  KAKENHI-PROJECT-18K08446
[Presentation] 比較的稀な分子型梅毒トレポネーマの短期間内での複数回検出例2019
- Author(s)
  中山周一、井戸田一朗、大西　真
- Organizer
  日本性感染症学会第31回学術大会
- Data Source
  KAKENHI-PROJECT-18K09184
[Presentation] A novel detection procedure for mutations in the 23S rRNA gene of Treponema pallidum with peptide nucleic acid-mediated loop-mediated isothermal amplification assay2019
- Author(s)
  Norihito Tarumoto, Kazuo Imai, Jun Sakai, Kazuhisa Misawa, Shuichi Nakayama, Shigefumi Maesaki, Makoto Ohnishi, Takuya Maeda
- Organizer
  the 29th European Congress of Clinical Microbiology & Infectious Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08446
[Presentation] 梅毒核酸検査における唾液やうがい液の有用性についての検討2019
- Author(s)
  花岡　希、中山周一、尾上泰彦、錦　信吾、萬田和志、大西　真
- Organizer
  日本性感染症学会第31回学術大会
- Data Source
  KAKENHI-PROJECT-18K09184
[Presentation] PNA-LAMP法を用いたマクロライド耐性梅毒トレポネーマの検出に関する検討2019
- Author(s)
  樽本憲人、前崎繁文、前田拓哉、中山周一、大西真、早川　智、井戸田一朗
- Organizer
  日本性感染症学会第32回学術大会
- Data Source
  KAKENHI-PROJECT-18H02659
[Presentation] Infective endocarditis due to Treponema pallidum: A case diagnosed by polymerase chain reaction analysis of aortic valve.2018
- Author(s)
  Hijikata, S., Hongo I., Nakayama, S., Sekikawa, Y., Iwai, T., Yamaguchi J., Sagawa, Y., Watanabe, K., Masuda, R., Miyazaki, R., Miwa, N., Hara, N., Yamaguchi, T., Nagata, Y., Nozato, T., and Hirano, K.
- Organizer
  The 82nd Annual Scientific Meeting of the Japanese Circulation Society.
- Data Source
  KAKENHI-PROJECT-18K09184
[Presentation] 2015～2017年にわが国で分離された淋菌の薬剤感受性報告。2018
- Author(s)
  安田　満、志牟田　健、中山周一、小林寅喆、大澤佳代、陳内理生、三宅啓文、濱砂良一、荒川創一、大西　真。
- Organizer
  日本性感染症学会第31回学術大会。
- Data Source
  KAKENHI-PROJECT-18K09184
[Presentation] 梅毒の迅速診断の方向性―検査手技時間の短縮化と感染成立後陽性判定可能までのタイムラグの短縮化を目指す。2018
- Author(s)
  中山周一
- Organizer
  日本性感染症学会第31回学術大会。シンポジウム 1。
- Data Source
  KAKENHI-PROJECT-18K09184

1. OHNISHI Makoto (10233214)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. SHIMUTA Ken (40370960)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. YAMAMOTO Shingo (80322741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Tarumoto Norihito (00746993)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 前田卓哉 (20383763)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 早川智 (30238084)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. SUZUKI Masato

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 高橋英之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 安田満

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakayama Shu-ichi 中山 周一

中山 周一 ナカヤマ シユウイチ

NAKAYAMA Shu-ichi 中山 周一

Research Projects

Research Products

Co-Researchers

Evaluation and application of putative SNPs that can define the lineages of T.pallidumPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of detection procedure for macrolide-resistant Treponema pallidum with peptide nucleic acid-mediated loop-mediated isothermal amplification assay

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Systematic re-estimation of polymorphism of T. pallidum genome from wider range of specimens including T. p DNA of lower copy numbersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Origin of drug resistant gene of Neisseria gonorrhoeae.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Model for evaluation of pathogenicity of extra-intestinal pathogenic Escherichia coli

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

サルモネラcpxR-A遺伝子の宿主細胞侵入能及び病原性への関与の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

赤痢菌virF遺伝子のcpxA-R2コンポーネント制御系による発現制御の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] High-throughput nanopore sequencing of Treponema pallidum tandem repeat genes arp and tp0470 reveals clade-specific patterns and recapitulates global whole genome phylogeny.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phylogenetic and Genetic Characterization of Treponema pallidum Strains from Syphilis Patients in Japan by Whole-genome Sequence Analysis from Global Perspectives.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome Sequencing of 196 Treponema pallidum strains from six continents reveals additional variability in vaccine candidate genes and dominance of Nichols clade strains in Madagascar.2021

Author(s)

Journal Title

Data Source

[Journal Article] Emergence and evolution of antimicrobial resistance genes and mutations in Neisseria gonorrhoeae2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epidemiology, Molecular Strain Types, and Macrolide Resistance of Treponema pallidum in Japan, 2017-2018.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel peptide nucleic acid- and loop-mediated isothermal amplification assay for the detection of mutations in the 23S rRNA gene of Treponema pallidum2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of two Neisseria gonorrhoeae strains with high-level azithromycin resistance isolated in 2015 and 2018 in Japan2020

Author(s)

Journal Title

Nakayama Shu-ichi 中山周一

中山周一ナカヤマシユウイチ

NAKAYAMA Shu-ichi 中山周一

[Presentation] 梅毒：迅速診断の展望とゲノム解析結果から見える国内株の系統位置2022

[Presentation] PNA-LAMP法を用いたマクロライド耐性梅毒トレポネーマの検出に関する検討2019