HAKUNO Daihiko 伯野大彦

… Alternative Names

Researcher Number	80286476
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2018: 京都大学, 医学研究科, 医員 2016: 京都大学, 医学研究科, 医員 2012: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 病院, 講師 2011 – 2012: 防衛医科大学校, 病院, 講師 2010: 防衛医科大学校, 病院, 助教 2007 – 2008: Keio University, 医学部, 助教 2000 – 2002: 慶應義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine / Biological Sciences / Circulatory organs internal medicine / Cardiovascular medicine
Keywords	Principal Investigator 血管新生 / 幹細胞 / 心筋細胞 / カテコラミン受容体 / アセチルコリン受容体 / シグナル伝達 / 骨髄間葉系幹細胞 / シゲナル伝達 / 心臓弁 / VEGF … More Except Principal Investigator 心筋細胞 / 心不全 / 幹細胞 / 再生医学 / 分化誘導 / 骨髄 / 細胞移植 / 骨髄間葉系幹細胞 / 再生 / 多能性幹細胞 / 発生分化 / 心筋細胞移植 / 転写因子 / 交感神経 / エンドセリン / 星状神経節 / 神経成長因子 / チロシンヒドロキシラーゼ / 再生医療 / 発生・分化 / Cardiomyocyte / stem cell / regerative medicine / bone marrow / 臍胎血 / 血管内皮細胞 / 臍帯血 / 心臓弁膜症 / 血管新生 / テノモジュリン / マトリックスメタロプロテアーゼ / 腱索 / 僧帽弁閉鎖不全症 / 細胞分化 / 骨髄細胞 / 発生 / STEM CELL / REGENERATION / BONE MARROW / CARDIOMYOCYTE / TRANSDIFFERENTIATION / HEART FAILURE / TRANSPLANTATION / CD抗原 / 表面抗原 / FACS / 多分化能 / 間葉系幹細胞 / 細胞増殖因子 / サイトカイン / cardiomyocytes / Stem cell / Bone Marrow mesenchymal stem cell / Cell transplantation therapy / Differentiation / CD antigen / Regenerative medicine / neoatherosclerosis / 大動脈弁狭窄症 / microRNA / nardilysin / ステント / Neoatherosclerosis / マイクロRNA / 退行性血管病変 / 大動脈弁狭窄 / NRDc / 動脈硬化 / 冠動脈疾患 / バイオマーカー / 病理 / ステント血栓症 / デバイス Less

Elucidation of the mechanisms of neoatherosclerosis and degenerative vascular disease and development of novel therapeutic strategy
- Principal Investigator
  
  Kimura Takeshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kyoto University
Elucidation for the role of stress-responsive secretory proteins on the progression of atherosclerotic aortic valves and vascular diseasesPrincipal Investigator
- Principal Investigator
  
  HAKUNO Daihiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Defense Medical College
心臟弁に発現する血管新生抑制因子テノモジュリンの機能解析
- Principal Investigator
  
  福田恵一
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Keio University
Functional analysis of antiangiogenic factor periostin in the cardiac valvePrincipal Investigator
- Principal Investigator
  
  HAKUNO Daihiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Keio University
臍帯血細胞を用いた心筋細胞の分化誘導
- Principal Investigator
  
  福田恵一
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Keio University
Establishment of a method to induce cardiomyocyte differetiation from bone marrow mesenchymal stem cell
- Principal Investigator
  
  FUKUDA Keiichi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Keio University
骨髄細胞を用いた心不全の細胞移植治療
- Principal Investigator
  
  FUKUDA Keiichi
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
骨髄間質細胞由来の心筋細胞におけるカテコラミン、アセチルコリン受容体の発現解析Principal Investigator
- Principal Investigator
  
  伯野大彦
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Keio University
ESTABLISHMENT OF THE HEART FAILURE THERAPY USING REGENERATED CARDIOMYOCYTE FROM BONE MARROW
- Principal Investigator
  
  OGAWA Satoshi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Keio University

All 2018 2017 2016 2013 2011 2010 2008 2007

All Journal Article Presentation Book

[Book] 循環器疾患のサイエンス2010
- Author(s)
  伯野大彦、福田恵一
- Total Pages
  7
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-22590833
[Book] 循環器疾患のサイエンス2010
- Author(s)
  伯野大彦
- Total Pages
  7
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-22590833
[Journal Article] MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart by Preserving Lipid Raft CholesterolNovelty and Significance2017
- Author(s)
  Nishiga M, Horie T, Kuwabara Y, Nagao K, Baba O, Nakao T, Nishino T, Hakuno D, Nakashima Y, Nishi H, Nakazeki F, Ide Y, Koyama S, Kimura M, Hanada R, Nakamura T, Inada T, Hasegawa K, Conway SJ, Kita T, Kimura T, Ono K.
- Journal Title
  
  Circ Res
  
  Volume: - Pages: 835-847
- DOI
  10.1161/circresaha.116.309528
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05297, KAKENHI-PROJECT-14J05148, KAKENHI-PROJECT-26293186, KAKENHI-PROJECT-26461144, KAKENHI-PROJECT-16K09497, KAKENHI-PROJECT-16K19400, KAKENHI-PROJECT-17K09860, KAKENHI-PROJECT-17K19534, KAKENHI-PROJECT-16H05145, KAKENHI-PROJECT-17H04177, KAKENHI-PROJECT-16H06900, KAKENHI-PROJECT-15K09108, KAKENHI-PROJECT-17K19590, KAKENHI-PUBLICLY-17H05599
[Journal Article] ぺリオスチンと心臓弁膜症特集「Matricellularタンパク」2013
- Author(s)
  伯野大彦
- Journal Title
  
  臨床化学
  
  Volume: 42巻 Pages: 44-49
- Data Source
  KAKENHI-PROJECT-22590833
[Journal Article] ぺリオスチンと心臓弁膜症　特集「Matricellularタンパク」2013
- Author(s)
  伯野　大彦
- Journal Title
  
  臨床化学
  
  Volume: 42 Pages: 44-49
- Data Source
  KAKENHI-PROJECT-22590833
[Journal Article] Role of Angiogenetic Factors in Cardiac Valve Homeostasis and Disease2011
- Author(s)
  伯野大彦、木村成卓、吉岡正豊、福田恵一
- Journal Title
  
  Journal of Cardiovascular Translational Research
  
  Volume: 4巻 Pages: 727-740
- DOI
  10.1007/s12265-011-9317-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590833
[Journal Article] Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents2010
- Author(s)
  伯野大彦、木村成卓、吉岡正豊、向井万起男、木村徳宏、岡田保典、四津良平、宿南知佐、開祐司、工藤明、小川聡、福田恵一
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 120巻 Pages: 2292-2306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590833
[Journal Article] 心臓弁膜症と血管新生抑制因子コンドロモデュリン-I2010
- Author(s)
  伯野大彦、福田恵一
- Journal Title
  
  Vascular Medicine
  
  Volume: 73巻 Pages: 168-176
- Data Source
  KAKENHI-PROJECT-22590833
[Journal Article] Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents.2010
- Author(s)
  伯野大彦
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 120巻 Pages: 2292-2306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590833
[Journal Article] Role of anti-angiogenic factor chondromodulin-I for maintaining cardiacvalvular function.2007
- Author(s)
  Daihiko Hakuno. Keiichi Fukuda.
- Journal Title
  
  Clin Calcium 17
  
  Pages: 361-372
- Data Source
  KAKENHI-PROJECT-19790540
[Presentation] MicroRNA-33b promotes atherosclerotic plaque formation in Apoe-/- mice2018
- Author(s)
  Nishino T, Horie T, Baba O, Kuwabara Y, Hakuno D, Nakashima Y, Nakao T, Nishiga M, Kimura T, Ono K
- Organizer
  第82回日本循環器学会
- Data Source
  KAKENHI-PROJECT-16H05297
[Presentation] MicroRNA-33 promotes cardiac fibrosis by maintaining cellular lipid homeostasis.2016
- Author(s)
  Masataka Nishiga, Takahiro Horie, Yasuhide Kuwabara, Osamu Baba, Tetsushi Nakao, Tomohiro Nishino, Daihiko Hakuno, Yasuhiro Nakashima, Koji Hasegawa, Toru Kita, Takeshi Kimura, Koh Ono.
- Organizer
  KEYSTONE SYMPOSIA, Heart failure: Genetics, Genomics and Epigenetics (Z1)
- Place of Presentation
  Snowbird, Utah（アメリカ合衆国）
- Year and Date
  2016-04-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05297
[Presentation] Eole of Angiogenetic Factors in Cardiac Valve Homeostasis and Disease2011
- Author(s)
  Hakuno D, Yoshioka M, Kimura N, Fukuda K
- Organizer
  Bit's 3rd Annual International Congress of Cardiology
- Place of Presentation
  中国北京
- Year and Date
  2011-12-04
- Data Source
  KAKENHI-PROJECT-22590833
[Presentation] Role of Angiogenetic Factors in Cardiac Valve Homeostasis and Disease2011
- Author(s)
  伯野大彦、吉岡正豊、木村成卓、福田恵一
- Organizer
  Bit's 3rd Annual International Congress of Cardiology
- Place of Presentation
  北京(中国)
- Year and Date
  2011-12-04
- Data Source
  KAKENHI-PROJECT-22590833
[Presentation] Periostin Advances Cardiac Valve Degeneration by Inducing Angiogenesis and Matrix Metalloproteinase Production.2010
- Author(s)
  伯野大彦
- Organizer
  American Heart Association Scientific Sessions
- Place of Presentation
  米国シカゴ
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-22590833
[Presentation] Periostin Advances Cardiac Valve Degeneration by Inducing Angiogenesis and Matrix Metalloproteinase Production2010
- Author(s)
  伯野大彦、木村成卓、吉岡正豊、木村徳宏、岡田保典、四津良平、開祐司、工藤明、小川聡、福田恵一
- Organizer
  American Heart Association Scientific Sessions
- Place of Presentation
  シカゴ(米国)
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-22590833
[Presentation] The Potent Angiogenic Factor Periostin Accelerates Degeneration and Sclerosis of the Cardiac Valve Complex2008
- Author(s)
  伯野大彦
- Organizer
  The 25^<th> Annual Meeting of the International Society of Heart Research Japanese Section
- Place of Presentation
  横浜
- Year and Date
  2008-12-08
- Data Source
  KAKENHI-PROJECT-19790540
[Presentation] The Potent Angiogenic Factor Periostin Accelerates Degeneration and Sclerosis of the Cardiac Valve Complex.2008
- Author(s)
  伯野大彦
- Organizer
  The 25th Annual Meeting of the International Society of Heart Research Japanese Section,Symposium 4(Myocardial disease and vascular remodeling)
- Place of Presentation
  横浜
- Year and Date
  2008-12-08
- Data Source
  KAKENHI-PROJECT-19790540
[Presentation] 血管新生因子ペリオスチンは心臓弁複合体の変性・硬化を促進する2008
- Author(s)
  伯野大彦
- Organizer
  第30回心筋生検研究会ミニシンポジウム
- Place of Presentation
  津
- Year and Date
  2008-11-28
- Data Source
  KAKENHI-PROJECT-19790540
[Presentation] Periostin is a potent angiogenic factor and involved in degeneration of the cardiac valves.2008
- Author(s)
  Daihiko Hakuno, Naritaka Kimura Keiichi Fukuda, et. al.
- Organizer
  第72回日本循環器学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2008-03-30
- Data Source
  KAKENHI-PROJECT-19790540
[Presentation] A potent angiogenic factor periostin accelerates degeneration of the cardiac valves2008
- Author(s)
  伯野大彦
- Organizer
  第12回日本心不全学会学術集会
- Place of Presentation
  東京
- Year and Date
  2008-10-17
- Data Source
  KAKENHI-PROJECT-19790540
[Presentation] Periostin is a potent angiogenic factor and involved in degeneration of the cardiac valves2008
- Author(s)
  伯野大彦
- Organizer
  第72回日本循環器学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2008-03-30
- Data Source
  KAKENHI-PROJECT-19790540
[Presentation] The Potent Angiogenic Factor Periostin Accelerates Degeneration and Sclerosis of the Cardiac Valve Complex2008
- Author(s)
  Hakuno D
- Organizer
  The 81st American Heart Association Scientific Sessions
- Place of Presentation
  New Orleans, USA
- Year and Date
  2008-11-11
- Data Source
  KAKENHI-PROJECT-19790540
[Presentation] The Potent Angiogenic Factor Periostin Accelerates Degeneration and Sclerosis of the Cardiac Valve Complex2008
- Author(s)
  伯野大彦
- Organizer
  The 81^<st>American Heart Association Scientific Sessions
- Place of Presentation
  New Orleans, USA
- Year and Date
  2008-11-11
- Data Source
  KAKENHI-PROJECT-19790540
[Presentation] 血管新生因子ペリオスチンは心臓弁複合体の変性・硬化を促進する2008
- Author(s)
  伯野大彦
- Organizer
  第30回心筋生検研究会ミニシンポジウム1:動物モデルからヒト疾患への展開
- Place of Presentation
  津
- Year and Date
  2008-11-28
- Data Source
  KAKENHI-PROJECT-19790540
[Presentation] The anti-angiogenetic factor, Tenomodulin, has a pivotal role in maintaining avascularity of chordae tendineae cordis2007
- Author(s)
  Naritaka Kimura, Daihiko Hakuno, Chisa Shukunami, Yuji Hiraki, Ryohei Yozu, Keiichi Fukuda
- Organizer
  merican Heart Association, 79th Scientific Meeting
- Place of Presentation
  米国フロリダ州オーランド
- Year and Date
  2007-11-05
- Data Source
  KAKENHI-PROJECT-19659206

1. FUKUDA Keiichi (20199227)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
2. TOMITA Yuichi (00296568)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. TAKAHASHI Eiichi (00276247)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. FUJITA Jun (10306706)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. ITABASHI Yuji (00317108)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. YAGI Takashi (40317136)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. 田原聡子 (80296566)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 佐藤敏彦 (40286464)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. MIYOSHI Shunichiro (10296577)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. OGAWA Satoshi (90124940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KATOH Takahiro (60276219)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Kimura Takeshi (80359786)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. 尾野亘 (00359275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. 芦田昇 (00538978)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 齋藤成達 (20467484)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 西英一郎 (30362528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
17. 森本剛 (30378640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 今井逸雄 (10625677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. HORIE Takahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. KUWABARA Yasuhide

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 中邨智之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 中島康弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 西賀雅隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 長谷川浩二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HAKUNO Daihiko 伯野 大彦

伯野 大彦 ハクノ ダイヒコ

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanisms of neoatherosclerosis and degenerative vascular disease and development of novel therapeutic strategy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation for the role of stress-responsive secretory proteins on the progression of atherosclerotic aortic valves and vascular diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

心臟弁に発現する血管新生抑制因子テノモジュリンの機能解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of antiangiogenic factor periostin in the cardiac valvePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

臍帯血細胞を用いた心筋細胞の分化誘導

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of a method to induce cardiomyocyte differetiation from bone marrow mesenchymal stem cell

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

骨髄細胞を用いた心不全の細胞移植治療

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

骨髄間質細胞由来の心筋細胞におけるカテコラミン、アセチルコリン受容体の発現解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ESTABLISHMENT OF THE HEART FAILURE THERAPY USING REGENERATED CARDIOMYOCYTE FROM BONE MARROW

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 循環器疾患のサイエンス2010

Author(s)

Total Pages

Publisher

Data Source

[Book] 循環器疾患のサイエンス2010

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart by Preserving Lipid Raft CholesterolNovelty and Significance2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ぺリオスチンと心臓弁膜症 特集「Matricellularタンパク」2013

Author(s)

Journal Title

Data Source

[Journal Article] ぺリオスチンと心臓弁膜症 特集「Matricellularタンパク」2013

Author(s)

HAKUNO Daihiko 伯野大彦

伯野大彦ハクノダイヒコ

[Journal Article] ぺリオスチンと心臓弁膜症特集「Matricellularタンパク」2013

[Journal Article] ぺリオスチンと心臓弁膜症　特集「Matricellularタンパク」2013