Monkawa Toshiaki 門川俊明

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MONKAWA Toshiaki 門川俊明

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Researcher Number	80286484
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 教授
Affiliation (based on the past Project Information) *help	2015 – 2017: 慶應義塾大学, 医学部(信濃町), 教授 2014 – 2015: 慶應義塾大学, 医学部, 教授 2009 – 2013: Keio University, 医学部, 講師 2007 – 2008: Keio University, School of Medicine, Instructor 2006: 慶應義塾大学, 医学部, 助手 2003 – 2004: 慶應義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Kidney internal medicine Except Principal Investigator Kidney internal medicine / Endocrinology
Keywords	Principal Investigator 腎臓 / iPS細胞 / ES細胞 / 尿細管 / 再生 / Gs15 / LIF / Cre-loxP / miRNA / 再生医学 … More / EMT / 尿細管細胞 / 腎線維化 / micro RNA / 転写因子 / 腎臓尿細管 / Snail1 / regeneration / kidney / STAT3 / Cre-LoxP / Gsl5 / Snail / 分化誘導 / ips細胞 / 高速in situ hybridization法 / 後腎 / 発生 … More Except Principal Investigator NF-κB / DNA microarray / ES細胞 / 転写調節因子 / 腎臓 / 転写因子 / 尿細管 / angiotensin converting enzyme type 2 / Thymosin β-10 / Thy 1.1 nephritis / progressive renal diseases / NFκB / NKκB / アンジオテンシン変換酵素2型 / Thymosin β10 / Thy1.1腎炎 / 進行性腎障害 / 動脈硬化性疾患 / 再生医療 / 血管老化 / 血管内皮細胞 / iPS細胞 Less

Master regulatory factors for regeneration and EMT of kidney tubular cellsPrincipal Investigator
- Principal Investigator
  
  Monkawa Toshiaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
The direct differentiation method of renal tubular cells by master transcription factors identified from TF-inducible human ES bank
- Principal Investigator
  
  Hiroshi Itoh
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
An investigation of mechanism of progression of kidney disease using renal tubular cells differentiated from ES/iPS cellsPrincipal Investigator
- Principal Investigator
  
  MONKAWA Toshiaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
Mechanism of regeneration of renal tubular cells and differentiation from ES and iPS cells to renal tubular cellsPrincipal Investigator
- Principal Investigator
  
  MONKAWA Toshiaki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
ES細胞を用いた幹細胞代謝と老化に対する心血管ホルモンの作用とメタボローム解析
- Principal Investigator
  
  Hiroshi Itoh
- Project Period (FY)
  2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Endocrinology
- Research Institution
  Keio University
LIF-STAT3 on renal tubular regeneration process examined by Cre/loxP systemPrincipal Investigator
- Principal Investigator
  
  MONKAWA Toshiaki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
高速in situハイブリダイゼーション法を用いた腎発生再生に関わる遺伝子の探索Principal Investigator
- Principal Investigator
  
  門川俊明
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
Identification of target molecule for the treatment of progressive renal diseases and its application for gene therapy.
- Principal Investigator
  
  HAYASHI Matsuhiko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University

All 2017 2016 2015 2014 2013 2012 2011 2009 2007 2004 2003

All Journal Article Presentation Patent

[Journal Article] miR-363 induces transdifferentiation of human kidney tubular cells to mesenchymal phenotype2016
- Author(s)
  Morizane R, Fujii S, Monkawa T, Hiratsuka K, Yamaguchi S, Homma K, Itoh H.
- Journal Title
  
  Clin Exp Nephrol
  
  Volume: 20 Issue: 3 Pages: 394-401
- DOI
  10.1007/s10157-015-1167-2
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09273
[Journal Article] miR-34c attenuates epithelial-mesenchymal transition and kidney fibrosis with ureteral obstruction2014
- Author(s)
  Ryuji Morizane, Shizuka Fujii, Toshiaki Monkawa, Ken Hiratsuka, Shintaro Yamaguchi1, Koichiro Homma, Hiroshi Itoh
- Journal Title
  
  Scientific Reports
  
  Volume: 4 Issue: 1
- DOI
  10.1038/srep04578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591211
[Journal Article] Selective depletion of mouse kidney proximal straight tubule cells causes acute kidney injury2012
- Author(s)
  Sekine M, Monkawa T, Morizane R, Matsuoka K, Taya C, Akita Y, Joh K, Itoh H, Hayashi M, Kikkawa Y, Kohno K, Suzuki A, Yonekawa H.
- Journal Title
  
  Transgenic Res
  
  Volume: 21 Pages: 51-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591038
[Journal Article] The role of microRNA-145 in human embryonic stem cell differentiation into vascular cells2011
- Author(s)
  Yamaguchi S, Yamahara K, Homma K, Suzuki S, Fujii S, Morizane R, Monkawa T, Matsuzaki Y, Kangawa K, Itoh H
- Journal Title
  
  Atherosclerosis
  
  Volume: 219 Pages: 468-474
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591038
[Journal Article] Differentiation of murine embryonic stem and induced pluripotent stem cells to renal lineage in vitro2009
- Author(s)
  Morizane R, Monkawa T, Itoh H.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 390 Pages: 1334-1339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591038
[Journal Article] 腎の再生因子の探索2007
- Author(s)
  門川俊明
- Journal Title
  
  医学のあゆみ 220
  
  Pages: 507-510
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590902
[Journal Article] Spironolactone in combination with cilazapril ameliorates proteinuria and renal interstitial fibrosis in rats with anti-Thy-1 irreversible nephritis.2004
- Author(s)
  Asai M, Monkawa T, Marumo T, Fukuda S, Tsuji M, Yoshino J, Kawachi H, Shimizu F, Hayashi M, Saruta T
- Journal Title
  
  Hypertension Research 27・12
  
  Pages: 971-978
- NAID
  10014466958
- Data Source
  KAKENHI-PROJECT-15659205
[Journal Article] Spironolactone in combination with cilazapril ameliorates proteinuria and renal interstitial fibrosis in rats with anti-Thy-i irreversible nephritis.2004
- Author(s)
  Asai M, Monkawa T, Marumo T, Fukuda S, Tsuji M, Yoshino J, Kawachi H, Shimizu F, Hayashi M, Saruta T
- Journal Title
  
  Hypertension Research 27(12)
  
  Pages: 971-978
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590859
[Journal Article] Spironolactone in combination with cilazapril ameliorates proteinuria and renal interstitial fibrosis in rats with anti-Thy-1 irreversible nephritis.2004
- Author(s)
  Asai M, Monkawa T, et al.
- Journal Title
  
  Hypertension Research 27巻12号
  
  Pages: 971-978
- NAID
  10014466958
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590859
[Journal Article] Leukemia inhibitory factor is involved in tubular regeneration after experimental acute renal failure.2003
- Author(s)
  Yoshino J, Monkawa T, et al.
- Journal Title
  
  Journal of American Society of Nephrology 14巻12号
  
  Pages: 3090-3101
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590859
[Journal Article] Leukemia inhibitory factor is involved in tubular regeneration after experimental acute renal failure.2003
- Author(s)
  Yoshino J, Monkawa T, Tsuji M, Hayashi M, Saruta T.
- Journal Title
  
  Journal of American Society of Nephrology 14(12)
  
  Pages: 3090-3101
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590859
[Patent] 抗KSPマウスモノクローナル抗体を用いた、胚性幹細胞からin vitroでの腎構成細胞の誘導方法の開発2011
- Inventor(s)
  森實隆司、門川俊明、伊藤裕
- Industrial Property Rights Holder
  慶應義塾大学
- Industrial Property Number
  2011-209792
- Filing Date
  2011-09-26
- Data Source
  KAKENHI-PROJECT-21591038
[Patent] 抗KSPマウスモノクローナル抗体を用いた、胚性幹細胞からin vitroでの腎構成細胞の誘導方法の開発2011
- Inventor(s)
  森實隆司、門川俊明、伊藤裕
- Industrial Property Rights Holder
  慶應義塾大学
- Filing Date
  2011-09-26
- Data Source
  KAKENHI-PROJECT-21591038
[Presentation] Multi-segmented kidney organoids derived from human ES cells by stepwise transcription factor administration2017
- Author(s)
  Ken Hiratsuka, Toshiaki Monkawa, Shintaro Yamaguchi, Ryuji Morizane, Shigeru B.H. Ko, Hiroshi Itoh, Minoru S.H. Ko
- Organizer
  Kidney Week 2017(ASN)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09273
[Presentation] A novel method to differentiate human ES cells into renal tubule-like cells by a combination of transcription factors administration2016
- Author(s)
  Ken Hiratsuka, Toshiaki Monkawa, Shintaro Yamaguchi, Ryuji Morizane, Shigeru B.H. Ko, Hiroshi Itoh, Minoru S.H. Ko
- Organizer
  Kidney Week2016(ASN)
- Place of Presentation
  シカゴ（米国）
- Year and Date
  2016-11-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09273
[Presentation] ヒト多能性幹細胞から腎尿細管様細胞への分化誘導法の開発2016
- Author(s)
  平塚　健, 門川俊明, 秋山智彦, 中武悠樹, Sravan Kumar Goparaju, 相馬淳美, 小林紗恵子, 納富奈々, 木村寛美, 山口慎太郎, 森實隆司, 鈴木さゆり, 松下美紗子, 平山雅敏, 洪　繁, 伊藤　裕、洪　実
- Organizer
  第15回日本再生医療学会総会
- Place of Presentation
  大阪国際会議場(大阪府大阪市)
- Year and Date
  2016-03-17
- Data Source
  KAKENHI-PROJECT-26670432
[Presentation] ヒト尿細管マスター制御因子の検索と、転写因子をコードする修飾合成mRNAを用いたヒト多能性幹細胞から尿細管様細胞への分化誘導方法の開発2016
- Author(s)
  平塚　健, 門川俊明, 秋山智彦, 中武悠樹, Sravan Kumar Goparaju, 小林紗恵子, 納富奈々, 木村寛美, 山口慎太郎, 森實隆司, 鈴木さゆり, 洪　繁, 洪　実, 伊藤　裕
- Organizer
  第7回分子腎臓フォーラム
- Place of Presentation
  ベルサール八重洲（東京都中央区）
- Data Source
  KAKENHI-PROJECT-15K09273
[Presentation] The Direct Differentiation Method of Renal Tubular Cells by Synthetic mRNAs of Transcription Factors Identi ed from TF-Inducible Human ES Bank2015
- Author(s)
  Ken Hiratsuka, Toshiaki Monkawa, Shintaro Yamaguchi, Ryuji Morizane, Shigeru B.h. Ko, Minoru S.h. Ko, Hiroshi Itoh
- Organizer
  Kidney Week 2015
- Place of Presentation
  San Diego, CA, USA
- Year and Date
  2015-11-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09273
[Presentation] The direct differentiation method of renal tubular cells by synthetic mRNAs of transcription factors identified from TF-inducible human ES bank2015
- Author(s)
  Ken Hiratsuka, Toshiaki Monkawa, Shintaro Yamaguchi, Ryuji Morizane, Shigeru B.h. Ko, Minoru S.h. Ko, Hiroshi Itoh
- Organizer
  the ASN Kidney Week 2015 Annual Meeting
- Place of Presentation
  San Diego, CA(USA)
- Year and Date
  2015-11-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670432
[Presentation] miR-363 Induces Transdifferentiation of Human Tubular Cells to Mesenchymal Phenotype.2014
- Author(s)
  Ryuji Morizane, Toshiaki Monkawa, Shizuka Fujii, Hiroshi Itoh
- Organizer
  Kidney Week
- Place of Presentation
  米国フィラデルフィア
- Year and Date
  2014-11-14
- Data Source
  KAKENHI-PROJECT-24591211
[Presentation] ヒトES細胞を用いた尿細管上皮細胞の分化誘導の試み.2013
- Author(s)
  5. 山口慎太郎, 本間康一郎, 門川俊明, 森實隆司, 鈴木さゆり, 藤井静花, 脇野修, 林晃一, 伊藤裕
- Organizer
  第56回日本腎臓学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591211
[Presentation] Differentiation of Human Embryonic Stem Cells into Kidney Specific Protein Positive Cells.2013
- Author(s)
  2. Shintaro Yamaguchi, Koichiro Homma, Toshiaki Monkawa, Ryuji Morizane, Sayuri Suzuki, Shizuka Fujii, Shu Wakino, Koichi Hayashi, Hiroshi Itoh
- Organizer
  Kideny Week
- Place of Presentation
  米国アトランタ
- Data Source
  KAKENHI-PROJECT-24591211
[Presentation] miR-34c Ameliorates Renal Fibrosis via Down-Regulation of Jagged1.2013
- Author(s)
  Ryuji Morizane, Toshiaki Monkawa, Shizuka Fujii, Hiroshi Itoh
- Organizer
  Kidney Week
- Place of Presentation
  米国アトランタ
- Data Source
  KAKENHI-PROJECT-24591211
[Presentation] マウスES細胞を用いた尿細管細胞の分化誘導2012
- Author(s)
  森實隆司, 門川俊明, 伊藤裕
- Organizer
  日本腎臓学会
- Place of Presentation
  パシフィコ横浜（神奈川）
- Data Source
  KAKENHI-PROJECT-24591211
[Presentation] KSP-Positive Cells Derived from Mouse Embryonic Stem Cells Serve as Progenitors of Renal Tubule Cells2012
- Author(s)
  Ryuji Morizane, Toshiaki Monkawa, Shizuka Fujii, Hiroshi Itoh
- Organizer
  American Society of Nephrology
- Place of Presentation
  米国San Diego
- Data Source
  KAKENHI-PROJECT-24591211
[Presentation] Purification of differentiated tubular cells from mouse embryonic stem cells using flow cytometry2011
- Author(s)
  Morizane R, Monkawa T, Itoh H
- Organizer
  第44回米国腎臓学会
- Place of Presentation
  米国フィラデルフィア
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-21591038
[Presentation] Differentiation from mouse ES cell to tubule cell2011
- Author(s)
  Ryuji Morizane, Toshiaki Monkawa, Hiroshi Itoh
- Organizer
  Kidney Week 2011
- Place of Presentation
  フィラデルフィア、米国
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-21591038
[Presentation] 尿細管細胞の上皮間葉移行に関与するmiRNAの検討(miRNA involved with epithelial-mesenchymal transition of renal tubular cell)2011
- Author(s)
  森實隆司、門川俊明、山口慎太郎、伊藤裕
- Organizer
  第54回日本腎臓学会学術総会
- Place of Presentation
  日本、横浜
- Year and Date
  2011-06-17
- Data Source
  KAKENHI-PROJECT-21591038
[Presentation] Activin enhances differentiation of mouse ES cell to tubule cell2009
- Author(s)
  Morizane R, Monkawa T, Itoh H
- Organizer
  第42回米国腎臓学会
- Place of Presentation
  米国サンディエゴ
- Year and Date
  2009-10-31
- Data Source
  KAKENHI-PROJECT-21591038
[Presentation] マウスES細胞を用いた腎構成細胞への分化誘導(Differentiation to renal cell lineage from mouse ES cell)2009
- Author(s)
  森實隆司、門川俊明、西崇彦、伊藤裕
- Organizer
  第52回日本腎臓学会学術総会
- Place of Presentation
  日本、横浜
- Year and Date
  2009-06-03
- Data Source
  KAKENHI-PROJECT-21591038
[Presentation] Selective ablation of tubular cells in proximal tubule S3 segment mediated by diphtheria toxin receptor2007
- Author(s)
  Toshiaki, Monkawa
- Organizer
  American Society of Nephrology
- Place of Presentation
  San Francisco, USA
- Year and Date
  2007-11-03
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590902
[Presentation] Selective ablation of tubular cells in proximal tubule S3 segment mediated by diphtheria toxin receptor2007
- Author(s)
  Toshiaki, Monkawa
- Organizer
  Japanese Society of Nephrology
- Place of Presentation
  Hamamatsu
- Year and Date
  2007-05-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590902
[Presentation] Selective ablation of tubular cells in proximal tubule S3 segment mediated by diphtheria toxin receptor2007
- Author(s)
  Toshiaki Monkawa
- Organizer
  米国腎臓学会
- Place of Presentation
  米国サンフランシスコ
- Year and Date
  2007-11-03
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590902
[Presentation] ジフテリア毒素受容体を介した近位尿細管S3セグメント特異的除去マウスの作製2007
- Author(s)
  門川俊明
- Organizer
  第50回日本腎臓学会総会
- Place of Presentation
  浜松
- Year and Date
  2007-05-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590902

1. Ko Minoru (50631199)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. Hiroshi Itoh (40252457)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. HAYASHI Matsuhiko (60129608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. ASAI Masaki (50317103)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. SHIMODA Kouji (00129470)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 曽根正勝 (40437207)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Hiratsuka Ken

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

Monkawa Toshiaki 門川 俊明

MONKAWA Toshiaki 門川 俊明

Research Projects

Research Products

Co-Researchers

Master regulatory factors for regeneration and EMT of kidney tubular cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The direct differentiation method of renal tubular cells by master transcription factors identified from TF-inducible human ES bank

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

An investigation of mechanism of progression of kidney disease using renal tubular cells differentiated from ES/iPS cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of regeneration of renal tubular cells and differentiation from ES and iPS cells to renal tubular cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ES細胞を用いた幹細胞代謝と老化に対する心血管ホルモンの作用とメタボローム解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

LIF-STAT3 on renal tubular regeneration process examined by Cre/loxP systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

高速in situハイブリダイゼーション法を用いた腎発生再生に関わる遺伝子の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of target molecule for the treatment of progressive renal diseases and its application for gene therapy.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] miR-363 induces transdifferentiation of human kidney tubular cells to mesenchymal phenotype2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] miR-34c attenuates epithelial-mesenchymal transition and kidney fibrosis with ureteral obstruction2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Selective depletion of mouse kidney proximal straight tubule cells causes acute kidney injury2012

Author(s)

Journal Title

Data Source

[Journal Article] The role of microRNA-145 in human embryonic stem cell differentiation into vascular cells2011

Author(s)

Journal Title

Data Source

[Journal Article] Differentiation of murine embryonic stem and induced pluripotent stem cells to renal lineage in vitro2009

Author(s)

Journal Title

Data Source

[Journal Article] 腎の再生因子の探索2007

Author(s)

Journal Title

Description

Data Source

Monkawa Toshiaki 門川俊明

MONKAWA Toshiaki 門川俊明