Takai Shinji 高井真司

… Alternative Names

TAKAI Shinji 高井真司

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Researcher Number	80288703
Other IDs	https://orcid.org/0000-0003-3963-3983
External Links
Affiliation (Current)	2024: 大阪医科薬科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 大阪医科薬科大学, 医学部, 教授 2021 – 2023: 大阪医科薬科大学, 医学研究科, 教授 2016 – 2020: 大阪医科大学, 医学研究科, 教授 2017: 大阪医科大学, 医学部, 教授 2014 – 2015: 大阪医科大学, 医学(系)研究科(研究院), 教授 … More 2014 – 2015: 大阪医科大学, 医学部, 教授 2008 – 2014: Osaka Medical College, 医学部, 准教授 2013: 大阪医科大学, 薬理学, 准教授 2001 – 2006: 大阪医科大学, 医学部, 助教授 1998 – 2000: Osaka Medical College Department of Pharmacology, Instructor, 医学部, 講師 1996 – 1997: 大阪医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator General pharmacology / Basic Section 47040:Pharmacology-related / General pharmacology Except Principal Investigator Ophthalmology / General pharmacology / Digestive surgery / General pharmacology / Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 47060:Clinical pharmacy-related / Basic Section 90110:Biomedical engineering-related … More / Basic Section 56050:Otorhinolaryngology-related / Basic Section 56060:Ophthalmology-related / Basic Section 55020:Digestive surgery-related / Basic Section 55060:Emergency medicine-related / Basic Section 53040:Nephrology-related / Gastroenterology / Biomedical engineering/Biomaterial science and engineering / General surgery / Pediatric surgery / Thoracic surgery Less
Keywords	Principal Investigator キマーゼ / 阻害薬 / 高血圧 / 合併症 / 糖尿病 / メタボリックシンドローム / アンジオテンシンII / 炎症 / NASH / 動脈硬化 … More / 線維化 / 脂肪肝 / 高脂血症 / 網膜症 / 腎障害 / 生存率 / 心機能 / ハムスター / 心不全 / 心筋梗塞 / 核酸製剤 / 非アルコール性脂肪性肝炎 / 脂質異常症 / 腎臓障害 / 心臓障害 / 腎機能障害 / 心機能障害 / 血管機能障害 / 肝臓線維化 / ＮＡＳＨ / 血管障害 / 脳卒中 / 臓器線維化 / 内皮機能障害 / 肝線維化 / 大動脈瘤 / 臓器障害 / 組織線維化 / 血管 / 心臓 / 肥満細胞 / 組織繊維化 / Transforming growth factor-β / バルーンカテーテル / PTCA / キマーゼ阻害薬 / グラフト / バイパス / アンジオテンシン / 血管肥厚 / 12-リポキシゲナーゼ / 心血管リモデリング / 血管収縮反応 / 12-リポキシナーゼ / 12-ヒドロキシエイコサテトラエン酸 … More Except Principal Investigator キマーゼ / キマーゼ阻害薬 / 肥満細胞 / アンジオテンシンII / chymase / 阻害薬 / 非アルコール性脂肪性肝炎 / TNF-α / 網膜神経節細胞 / NASH / chymase inhibitor / myocardial infarction / 心筋梗塞 / ハムスター / ＭＭＰ / 視神経挫滅モデル / 人工血管 / 尿細管 / Kupffer細胞 / 脂肪由来幹細胞 / 再生医療 / 癒着防止 / 生分解性高分子 / ゾルゲル転移 / インジェクタブルポリマー / MMP-9 / MMP-2 / VEGF / TGF-β1 / cardiac function / 心機能 / angiotensin II / アンジオテンシンII受容体拮抗薬 / 動脈硬化 / 肝細胞壊死 / 酸化ストレス / マトリックスメタロプロテアーゼ / 免疫染色 / 炎症細胞 / セリンプロテアーゼ / 黄斑上膜 / 黄斑円孔 / 線維芽細胞 / イヌ / 内膜肥厚 / 治療 / 一酸化窒素 / CD68 / アストロサイト / ラット / 視神経挫滅 / 緑内障 / エプレレノン / PTFE / キマーゼ阻害 / 内膜再生 / 狭窄予防 / ペプチド修飾 / 口腔癌 / 唾液腺癌 / CDK5 / タウ蛋白 / 視神経傷害 / タウオパチー / GSK3β / LiCl / tau / 表面改質 / オリゴプロリン / アンチバイオファウリング / 血液適合性 / 体外設置型補助人工心臓 / メタボローム解析 / 肝細胞癌 / 組織分布 / 病態モデル動物 / 急性腎障害 / 腎疾患 / パンテテイン類縁体 / リード化合物 / 阻害剤 / 有機合成 / 創薬 / ドラッグデリバリーシステム / インジェクタブルポリマーゲル / 血管塞栓 / ドラッグデリバリー / 生分解性ポリマー / インジェクタブルポリマーゲ / miRNA / 急性膵炎 / 重症急性膵炎 / 新しい人工血管 / バスキュラーアクセス / PTFE人工血管 / コーティング / 人工血管素材 / 薬物治療 / 人工血管狭窄 / 腎線維化 / 食塩 / 腎障害 / 基礎研究 / 高血圧 / 食塩過剰摂取 / バイオマーカー / 尿細管障害 / 慢性腎臓病（CKD） / 非侵襲性 / 臨床研究 / Dahl salt-sensitive rat / 慢性腎臓病 / 食塩感受性高血圧 / バイオマーカ－ / 免疫組織染色 / 抗2型コラーゲン抗体 / ニューロステロイド / ニューステロイド / 抗２型コラーゲン抗体 / トリプターゼ / ワーバーグ効果 / PKM2 / MIR122-5p / microRNA / Warburg効果 / レニン / 生薬 / 予防効果 / 線維化 / 大豆サポニン / サーチュイン / 軸索変性 / SIRT-1 / NAMPT / 小胞体ストレス / neuroinflammation / rapamycin / sirtuin / NAD / mTOR / P7C3 / 心虚血 / 止血材 / tumor / angiogenesis / mast cell / マトリックスメタロプロテイネース(MMP)-2 / Vascular Endothelial Growth Factor(VEGF) / 腫瘍 / 血管新生 / hepatic fibrosis / cardiac fibrosis / angiotensrn II / シャント / 心筋症 / 精製 / 心不全 / 肝臓線維化 / 心臓線維化 / angiotensin II receptor blocker / angiotensin converting enzyme / aortic aneurysm / アンジオテンシン変換酵素 / アンジオテンシン / 大動脈瘤 / dog / humster / arrhythmia / liverbility / ischemia-reperfusion / 不整脈 / 生存率 / 虚血再灌流 / vascular proliferation / balloon injury / bypass graft / 血管肥厚 / バルーン障害 / バイパスグラフト / Atherosclerosis / Angiotensin II / Chymase / マキ-ゼ / キマ-ゼ / D-ガラクトサミン / リポポリサッカライド / 劇症肝炎 / モノクロタリン / 予防 / 肝類洞閉塞症候 / RT-PCR / マウス / 急性肝不全 / 視神経 / aquaporin-9 / aquaporin-4 / グルタミン / TGN-020 / aquaporin 4 / グルタミン酸 / aquaporin / 遺伝子 / リアルタイムPCR / 黄斑部 / 遺伝子発現 / 網膜幹細胞 / マイトマイシン / ゼラチンハイドロゲル / 眼圧 / 安全 / 濾過胞 / 徐放 / マイトマイシンC / ハイドロゲル / 濾過手術 / 国際情報交換 / 遊走 / 内腔狭窄 / 心臓手術 / ミネラルコクチコイド受容体 / アルドステロン / 肺高血圧症 / ミネラロコルチコイド受容体拮抗剤 / ミネラロコルチコイド受容体 / 肺高血圧 / real time-PCR / endothelin-1 / 活性化グリア細胞 / GFAP / endothelin / iNOS / NF-κB / NFκB / neuro-inflammation / simvastatin / NFκ B / スタチン / ミクログリア / p38 / Ox-ATP / IL-1β / BBG / OxATP / 急性眼圧上昇モデル / P2X7受容体 / 眼圧上昇 / P2X7 受容体 / 低酸素負荷マウス / 糖尿病黄斑浮腫 / 抗GBM抗体 / 低酸素負 / 硝子体手術 / 抗IV型コラーゲン抗体 / 抗II型コラーゲン抗体 / 自己免疫 / 糖尿病網膜症 / 眼免疫学 / 大動脈狭窄解除 / 大動脈弁狭 / ミネラロコルチコイド受容体拮抗 / アルドステロン系 / リモデリング / 大動脈弁置換術 / 間質線維化 / 左心室肥大 / 大動脈弁狭窄 / グラフト / アンジオテンシン変換酵素(ACE) / 血管内膜肥厚 / PTEE / 狭窄 / グラシル Less

Mast cells and therapeutic strategies in salivary gland adenoid cystic carcinoma and oral cancer.
- Principal Investigator
  
  東野正明
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Development of extracorporeal VAD housing having excellent blood compatibility using anti-fouling peptide immobilization technology
- Principal Investigator
  
  柿木佐知朗
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Kansai University
Pathophysiological role of chymase in diabetic complicationsPrincipal Investigator
- Principal Investigator
  
  高井真司
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Osaka Medical and Pharmaceutical University
タウのリン酸化抑制による神経保護の可能性-視神経傷害での検討
- Principal Investigator
  
  奥英弘
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Investigation of stenosis-preventive effect of bifunctionalized artificial blood vessels using peptide modification technology
- Principal Investigator
  
  柿木佐知朗
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Kansai University
Molecular mechanisms of involvment of vanin-1 with kidney disease and its application to drug discovery
- Principal Investigator
  
  細畑圭子
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Osaka Medical and Pharmaceutical University
メタボローム解析によるKupffer細胞代謝を標的としたNASH肝細胞癌の治療
- Principal Investigator
  
  廣川文鋭
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka Medical and Pharmaceutical University
腎透析のバスキュラーアクセスに用いる新しい素材からなる人工血管の開発
- Principal Investigator
  
  金徳男
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Osaka Medical and Pharmaceutical University
急性膵炎に対するChymaseによる病態解明とChymase阻害剤の創薬化研究
- Principal Investigator
  
  米田浩二
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Medical application of biodegradable injectable polymer gels having controllable degradation periods
- Principal Investigator
  
  大矢裕一
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Kansai University
Application of a novel nucleic acid agent for chymase-specific inhibitionPrincipal Investigator
- Principal Investigator
  
  TAKAI Shinji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Osaka Medical College
Clinical and basic studies of biomarker for earlydetection of chronic kidney disease in salt-sensitive hypertension
- Principal Investigator
  
  Hosohata Keiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Osaka University of Pharmaceutical Sciences
Possibility of prevention and treatment of NASH by soybean saponin
- Principal Investigator
  
  Hayashi Michihiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka Medical College
Elucidation of NASH pathogenesis by the cancer specific energy metabolic machinery regulatory gene
- Principal Investigator
  
  Hirokawa Fumitoshi
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka Medical College
Medical application of biodegradable injectable polymers forming covalent hydrogel in response to temperature
- Principal Investigator
  
  Ohya Yuichi
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Kansai University
Neuroprotective effects of P7C3 through activation of sirtuin gene and its application for optic nerve diseases.
- Principal Investigator
  
  Oku Hidehiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Osaka Medical College
Role of chymase on development and progression of organ damage induced by metabolic syndromePrincipal Investigator
- Principal Investigator
  
  TAKAI Shinji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka Medical College
Basic research for the pathogenesis of idiopathic epiretinal membranes
- Principal Investigator
  
  Ikeda Tsunehiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Osaka Medical College
Role of mast cell serine protease (chymase) on acute liver failure
- Principal Investigator
  
  HIROKAWA Fumitoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Osaka Medical College
reventive and ameliorative effects of chymase inhibitor and MMP inhibitor on sinusoidal obstruction syndrome
- Principal Investigator
  
  KOMEDA Koji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka Medical College
Effect of chymase inhibitor on fulminant hepatitis
- Principal Investigator
  
  Hayashi Michihiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka Medical College
Involvement of aquaporin in the formation of optic nerve edema and protective effects of blocking the AQP channels.
- Principal Investigator
  
  Oku Hidehiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Osaka Medical College
Mechanistic and therapeutic investigation of the outside fibroblasts involving the inner neointima formation after implantation of PTFE grafts.
- Principal Investigator
  
  JIN DENAN
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka Medical College
Establishment of sustained drug delivery system to inhibit scaring and synechia after glaucoma surgery
- Principal Investigator
  
  KOJIMA Shota
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Osaka Medical College
Retinal stem cell in the pathogenesis of macular diseases
- Principal Investigator
  
  IKEDA TSUNEHIKO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Osaka Medical College
Significance of chymase inhibition to prevent the complication of metabolic syndromePrincipal Investigator
- Principal Investigator
  
  TAKAI Shinji
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka Medical College
The role of chymase in the disease preocess of non-alcoholic staetohepatitis (NASH)
- Principal Investigator
  
  HAYASHI Michihiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka Medical College
Involvement of activated P2X7 receptor in disorder of retinal ganglion cells in animal models of glaucoma
- Principal Investigator
  
  SUGIYAMA Tetsuya
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Osaka Medical College
Determination of neuro-protective effects of statin on the retinal injuries through activated glial cells.
- Principal Investigator
  
  OKU Hidehiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Osaka Medical College
Mineralocorticoid receptor blockade attenuates proliferative changes in the rat pulmonary artery in monocrotaline-induced pulmonary hypertension
- Principal Investigator
  
  NEMOTO SHINTAROU
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatric surgery
- Research Institution
  Osaka Medical College
Investigation of the mechanisms involving PTFE graft occlusion and searching its pharmacotherapeutics with chymase inhibitor
- Principal Investigator
  
  JIN Denan
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka Medical College
Effects of mineralocorticoid receptor blockade on reverse remodeling of the left ventricle after pressure load reduction
- Principal Investigator
  
  OZAWA Hideki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Osaka Medical College
Autoimmune reaction for vitreous collagen in the pathogenesis of diabetic retinopathy
- Principal Investigator
  
  IKEDA Tsunehiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Osaka Medical College
Pathophysiological role of chymase in complications of metabolic syndromePrincipal Investigator
- Principal Investigator
  
  TAKAI Shinji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka Medical College
New Aspects of Mast-Cell Derived Chymase -Roles of Chymase in Vascularization and Tumor Development-
- Principal Investigator
  
  MIYAZAKI Mizuo
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka Medical College
キマーゼの心血管組識線維化における病態生理学的役割Principal Investigator
- Principal Investigator
  
  高井真司
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Osaka Medical College
Roles of chymase in the development of cardiac remodeling during heart failure progression.
- Principal Investigator
  
  JIN Denan
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka Medical College
Pathophysiological roles of chymase on cardiovascular disease
- Principal Investigator
  
  MIYAZAKI Mizuo
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka Medical College
Pathophysiological roles of the cardic renin-angiotensin system after myocardial infarction-Chymase dependent angiotensin II-forming pathway and myocardial infarction-
- Principal Investigator
  
  JIN Denan
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka Medical College
血管肥厚におけるキマーゼの役割の解明Principal Investigator
- Principal Investigator
  
  高井真司
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka Medical College
Pathophysiological role of chymase-dependent angiotensin II derived from cardiovascular tissues and its inhibitor
- Principal Investigator
  
  MIYAZAKI Mizuo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  General pharmacology
- Research Institution
  Osaka Medical College
12-リポキシゲナーゼの血圧に対する病態生理学的役割の解明Principal Investigator
- Principal Investigator
  
  高井真司
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka Medical College
Local and Pathophysiology Angiotensin II Forming System in Cardiovascular Tissues
- Principal Investigator
  
  MIYAZAKI Mizuo
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka Medical College

[Book] 日本臨床高血圧(第4版) 上巻2009
- Author(s)
  高井真司
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-20590265
[Journal Article] Increased Chymase-Positive Mast Cells in High-Grade Mucoepidermoid Carcinoma of the Parotid Gland2023
- Author(s)
  Nishimura Hiromi、Jin Denan、Kinoshita Ichita、Taniuchi Masataka、Higashino Masaaki、Terada Tetsuya、Takai Shinji、Kawata Ryo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 9 Pages: 8267-8267
- DOI
  10.3390/ijms24098267
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08601
[Journal Article] Chymase Inhibition Resolves and Prevents Deep Vein Thrombosis Without Increasing Bleeding Time in the Mouse Model2023
- Author(s)
  Lapointe Catherine、Vincent Laurence、Giguere Hugo、Auger‐Messier Mannix、Schwertani Adel、Jin Denan、Takai Shinji、Pejler Gunnar、Sirois Martin G.、Tinel Hanna、Heitmeier Stefan、D'Orleans‐Juste Pedro
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 12 Issue: 4
- DOI
  10.1161/jaha.122.028056
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08601
[Journal Article] Plasma Chymase Activity Reflects the Change in Hemodynamics Observed after the Surgical Treatment of Patent Ductus Arteriosus in Dogs2022
- Author(s)
  Shimada Kazumi、Hamabe Lina、Hirose Miki、Watanabe Momoko、Yokoi Aimi、Takeuchi Aki、Ozai Yusuke、Yoshida Tomohiko、Takai Shinji、Jin Denan、Kocaturk Meric、Uehara Katsumi、Tanaka Ryou
- Journal Title
  
  Veterinary Sciences
  
  Volume: 9 Issue: 12 Pages: 682-682
- DOI
  10.3390/vetsci9120682
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08601
[Journal Article] Pathophysiological Role of Chymase-Activated Matrix Metalloproteinase-92022
- Author(s)
  Takai Shinji、Jin Denan
- Journal Title
  
  Biomedicines
  
  Volume: 10 Issue: 10 Pages: 2499-2499
- DOI
  10.3390/biomedicines10102499
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08601
[Journal Article] Design, synthesis, and evaluation of new vanin-1 inhibitors based on RR62022
- Author(s)
  Yoneyama Hiroki、Hosohata Keiko、Jin Denan、Yoshida Iroha、Toyoda Miyui、Kitamura Ikuko、Takai Shinji、Usami Yoshihide
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 65 Pages: 116791-116791
- DOI
  10.1016/j.bmc.2022.116791
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08601
[Journal Article] Activation of Mast-Cell-Derived Chymase in the Lacrimal Glands of Patients with IgG4-Related Ophthalmic Disease2022
- Author(s)
  Fujita Yasushi、Jin Denan、Mimura Masashi、Sato Yohei、Takai Shinji、Kida Teruyo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 5 Pages: 2556-2556
- DOI
  10.3390/ijms23052556
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09428, KAKENHI-PROJECT-20K08601
[Journal Article] Downregulation of miR-122-5p Activates Glycolysis via PKM2 in Kupffer Cells of Rat and Mouse Models of Non-Alcoholic Steatohepatitis2022
- Author(s)
  Inomata Yosuke、Oh Jae-Won、Taniguchi Kohei、Sugito Nobuhiko、Kawaguchi Nao、Hirokawa Fumitoshi、Lee Sang-Woong、Akao Yukihiro、Takai Shinji、Kim Kwang-Pyo、Uchiyama Kazuhisa
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 9 Pages: 5230-5230
- DOI
  10.3390/ijms23095230
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08720
[Journal Article] In Vivo and In Vitro Evaluation of Urinary Biomarkers in Ischemia/Reperfusion-Induced Kidney Injury2021
- Author(s)
  Hosohata Keiko、Jin Denan、Takai Shinji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 21 Pages: 11448-11448
- DOI
  10.3390/ijms222111448
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08601, KAKENHI-PROJECT-21K06722
[Journal Article] Expression of Lymphatic Markers in the Berger’s Space and Bursa Premacularis2021
- Author(s)
  Morishita Seita、Sato Takaki、Oosuka Shou、Horie Taeko、Kida Teruyo、Oku Hidehiro、Nakamura Kimitoshi、Takai Shinji、Jin Denan、Ikeda Tsunehiko
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 4 Pages: 2086-2086
- DOI
  10.3390/ijms22042086
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09428, KAKENHI-PROJECT-20K08601
[Journal Article] Cellular therapy for myocardial ischemia using a temperature-responsive biodegradable injectable polymer system with adipose-derived stem cells2021
- Author(s)
  Yoshizaki Yuta、Ii Masaaki、Takai Hiroki、Mayumi Nozomi、Fujiwara Soichiro、Kuzuya Akinori、Ohya Yuichi
- Journal Title
  
  Science and Technology of Advanced Materials
  
  Volume: 22 Issue: 1 Pages: 627-642
- DOI
  10.1080/14686996.2021.1938212
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K18389, KAKENHI-PROJECT-20H00670
[Journal Article] Effectiveness of monitoring free carnitine levels for L-carnitine supplementation in hemodialysis patients to maintain carnitine sufficiency and nutritional factors2021
- Author(s)
  Kumagai E, Hosohata K, Furumachi K, Takai S.
- Journal Title
  
  Ther Apher Dial.
  
  Volume: 25 Issue: 5 Pages: 595-606
- DOI
  10.1111/1744-9987.13621
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06722
[Journal Article] Chymase as a Novel Therapeutic Target in Acute Pancreatitis2021
- Author(s)
  Kuramoto Toru、Jin Denan、Komeda Koji、Taniguchi Kohei、Hirokawa Fumitoshi、Takai Shinji、Uchiyama Kazuhisa
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 22 Pages: 12313-12313
- DOI
  10.3390/ijms222212313
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08601
[Journal Article] Decreased Presence of Mast Cells in the Bursa Premacularis of Proliferative Diabetic Retinopathy.2021
- Author(s)
  Ikeda T, Nakamura K, Morishita S, Sato T, Horie T, Kida T, Oku H, Takai S, Jin D.
- Journal Title
  
  Ophthalmic Res.
  
  Volume: 64. Issue: 6 Pages: 1002-1012
- DOI
  10.1159/000518438
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10002, KAKENHI-PROJECT-18K09428, KAKENHI-PROJECT-20K08601
[Journal Article] Postoperative Adhesion Prevention Using a Biodegradable Temperature-Responsive Injectable Polymer System and Concomitant Effects of the Chymase Inhibitor2021
- Author(s)
  Yoshizaki Yuta、Nagata Takuya、Fujiwara Soichiro、Takai Shinji、Jin Denan、Kuzuya Akinori、Ohya Yuichi
- Journal Title
  
  ACS Applied Bio Materials
  
  Volume: 4 Issue: 4 Pages: 3079-3088
- DOI
  10.1021/acsabm.0c01467
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K18389, KAKENHI-PROJECT-20H00670, KAKENHI-PROJECT-20K08601
[Journal Article] Increase in Chymase-Positive Mast Cells in Recurrent Pleomorphic Adenoma and Carcinoma Ex Pleomorphic Adenoma of the Parotid Gland2021
- Author(s)
  Kinoshita Ichita、Jin Denan、Higashino Masaaki、Terada Tetsuya、Kurisu Yoshitaka、Takai Shinji、Kawata Ryo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 23 Pages: 12613-12613
- DOI
  10.3390/ijms222312613
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08601, KAKENHI-PROJECT-21K09641
[Journal Article] Glaucocalyxin A Ameliorates Hypoxia/Reoxygenation-Induced Injury in Human Renal Proximal Tubular Epithelial Cell Line HK-2 Cells2021
- Author(s)
  Hosohata Keiko、Jin Denan、Takai Shinji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 1 Pages: 446-446
- DOI
  10.3390/ijms23010446
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08601, KAKENHI-PROJECT-21K06722
[Journal Article] Range of plasma brain natriuretic peptide (BNP) levels in hemodialysis patients at high risk of 1-year mortality and their relationship with the nutritional status: A retrospective cohort study in one institute.2020
- Author(s)
  Kumagai E, Hosohata K, Furumachi K, Takai S.
- Journal Title
  
  Renal Replacement Therapy
  
  Volume: 6 Pages: 32-32
- Open Access
- Data Source
  KAKENHI-PROJECT-18K06768
[Journal Article] A Chymase Inhibitory RNA Aptamer Improves Cardiac Function and Survival after Myocardial Infarction2019
- Author(s)
  Jin Denan、Takai Shinji、Nonaka Yosuke、Yamazaki Satoko、Fujiwara Masatoshi、Nakamura Yoshikazu
- Journal Title
  
  Molecular Therapy - Nucleic Acids
  
  Volume: 14 Pages: 41-51
- DOI
  10.1016/j.omtn.2018.11.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06709, KAKENHI-PROJECT-17K09741
[Journal Article] Immunohistological Study of Monkey Foveal Retina2019
- Author(s)
  Ikeda Tsunehiko、Nakamura Kimitoshi、Oku Hidehiro、Horie Taeko、Kida Teruyo、Takai Shinji
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 5258-5258
- DOI
  10.1038/s41598-019-41793-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09465, KAKENHI-PROJECT-16K11336, KAKENHI-PROJECT-18K09428
[Journal Article] Involvement of vanin-1 in ameliorating of oxidative renal injury in Dahl-salt sensitive rats.2019
- Author(s)
  Hosohata K, Jin D, Takai S, Iwanaga K.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 20 Issue: 18 Pages: 4481-4481
- DOI
  10.3390/ijms20184481
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06768
[Journal Article] Chymase inhibition retards albuminuria in type 2 diabetes2019
- Author(s)
  Bivona Benjamin J.、Takai Shinji、Seth Dale M.、Satou Ryousuke、Harrison‐Bernard Lisa M.
- Journal Title
  
  Physiological Reports
  
  Volume: 7 Issue: 24
- DOI
  10.14814/phy2.14302
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06709
[Journal Article] Early urinary biomarkers of renal tubular damage by a high-salt intake independent of blood pressure in normotensive rats.2018
- Author(s)
  Washino S, Hosohata K, Jin D, Takai S, Miyagawa T.
- Journal Title
  
  Clin Exp Pharmacol Physiol
  
  Volume: 45 Issue: 3 Pages: 261-268
- DOI
  10.1111/1440-1681.12871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06768
[Journal Article] Chymase Inhibitor as a Novel Therapeutic Agent for Non-alcoholic Steatohepatitis.2018
- Author(s)
  Takai S, Jin D.
- Journal Title
  
  Front Pharmacol
  
  Volume: 9 Pages: 144-144
- DOI
  10.3389/fphar.2018.00144
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08251
[Journal Article] Vanin-1 in Renal Pelvic Urine Reflects Kidney Injury in a Rat Model of Hydronephrosis.2018
- Author(s)
  Hosohata K, Jin D, Takai S, Iwanaga K.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 19 Issue: 10 Pages: 3186-3186
- DOI
  10.3390/ijms19103186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09741, KAKENHI-PROJECT-18K06768
[Journal Article] A novel hamster nonalcoholic steatohepatitis model induced by a high-fat and high-cholesterol diet2018
- Author(s)
  Miyaoka Y, Jin D, Tashiro K, Masubuchi S, Ozeki M, Hirokawa F, Hayashi M, Takai S, Uchiyama K.
- Journal Title
  
  Exp. Anim.
  
  Volume: 67 Issue: 2 Pages: 239-247
- DOI
  10.1538/expanim.17-0126
- NAID
  130006733605
- ISSN
  0007-5124, 1341-1357, 1881-7122
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08251, KAKENHI-PROJECT-26860176, KAKENHI-PROJECT-17K09443, KAKENHI-PROJECT-17K09741
[Journal Article] Biodegradable injectable polymer systems exhibiting a longer and controllable duration time of the gel state2017
- Author(s)
  Yoshida Yasuyuki、Takai Hiroki、Kawahara Keisuke、Mitsumune Shintaro、Takata Kazuyuki、Kuzuya Akinori、Ohya Yuichi
- Journal Title
  
  Biomaterials Science
  
  Volume: 5 Issue: 7 Pages: 1304-1314
- DOI
  10.1039/c7bm00357a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H01854
[Journal Article] Synthesis and temperature-responsiveness of poly(ethylene glycol)-like biodegradable poly(ether-ester)s2017
- Author(s)
  Yuichi Ohya, Akihiro Tahahashi, Hiroki Takaishi, Akinori Kuzuya
- Journal Title
  
  The ACS Symposium Series
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H01854
[Journal Article] Extemporaneously preparative biodegradable injectable polymer systems exhibiting temperature-responsive irreversible gelation2017
- Author(s)
  Yoshida Yasuyuki、Takata Kazuyuki、Takai Hiroki、Kawahara Keisuke、Kuzuya Akinori、Ohya Yuichi
- Journal Title
  
  Journal of Biomaterials Science, Polymer Edition
  
  Volume: 28 Issue: 14 Pages: 1427-1443
- DOI
  10.1080/09205063.2017.1330114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H01854
[Journal Article] Peptide Drug Release Behavior from Biodegradable Temperature-Responsive Injectable Hydrogels Exhibiting Irreversible Gelation2017
- Author(s)
  Takata Kazuyuki、Takai Hiroki、Yoshizaki Yuta、Nagata Takuya、Kawahara Keisuke、Yoshida Yasuyuki、Kuzuya Akinori、Ohya Yuichi
- Journal Title
  
  Gels
  
  Volume: 3 Issue: 4 Pages: 38-38
- DOI
  10.3390/gels3040038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H01854
[Journal Article] Chymase inhibitor prevents the development and progression of?non-alcoholic steatohepatitis in rats fed a high-fat and high-cholesterol diet2017
- Author(s)
  Miyaoka Yuta、Jin Denan、Tashiro Keitaro、Komeda Koji、Masubuchi Shinsuke、Hirokawa Fumitoshi、Hayashi Michihiro、Takai Shinji、Uchiyama Kazuhisa
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 134 Issue: 3 Pages: 139-146
- DOI
  10.1016/j.jphs.2017.04.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09741, KAKENHI-PROJECT-15K08251, KAKENHI-PROJECT-26860176
[Journal Article] Improvement of cardiovascular remodelling by chymase inhibitor2016
- Author(s)
  Takai S, Jin D.
- Journal Title
  
  Clin Exp Pharmacol Physiol
  
  Volume: 43 Issue: 4 Pages: 387-393
- DOI
  10.1111/1440-1681.12549
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08251
[Journal Article] Recombinant human soluble thrombomodulin improved lipopolysaccharide/d-galactosamine-induced acute liver failure in mice2015
- Author(s)
  Osumi W, Jin D, Imai Y, Tashiro K, Li ZL, Otsuki Y, Maemura K, Komeda K, Hirokawa F, Hayashi M, Takai S, Uchiyama K.
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 129 Issue: 4 Pages: 233-239
- DOI
  10.1016/j.jphs.2015.11.007
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08251
[Journal Article] The role of tryptase and anti-type Ⅱ collagen antibodies in the pathogenesis of idiopathic epiretinal membranes.2015
- Author(s)
  Ikeda T, Nakamura K, Oku H, Morishita S, Fukumoto M, Suzuki H, Kida T, Horie T, Sugiyama T, Takai S
- Journal Title
  
  Clin Ophthalmol
  
  Volume: 9 Pages: 1181-1186
- DOI
  10.2147/opth.s82015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10910
[Journal Article] Effects of Gelatin Hydrogel Loading Mitomycin C on Conjunctival Scarring in a Canine Filtration Surgery Model2015
- Author(s)
  Shota Kojima, Tetsuya Sugiyama, Shinji Takai, Denan Jin, Mari Ueki, Hidehiro Oku, Yasuhiko Tabata, Tsunehiko Ikeda
- Journal Title
  
  Investigative Ophthalmology and Visual Science
  
  Volume: 56 Issue: 4 Pages: 2601-2601
- DOI
  10.1167/iovs.15-16486
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592684
[Journal Article] The role of tryptase and anti-type II collagen antibodies in the pathogenesis of idiopathic epiretinal membranes2015
- Author(s)
  Tsunehiko Ikeda, Kimitoshi Nakamura, Hidehiro Oku, Seita Morishita, Masanori Fukumoto, Hiroyuki Suzuki, Teruyo Kida, Taeko Horie, Tetsuya Sugiyama, Shinji Takai
- Journal Title
  
  Clinical Ophthalmol
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592685
[Journal Article] Changes in Expression of Aquaporin-4 and Aquaporin-9 in Optic Nerve after Crushing in Rats2014
- Author(s)
  Hiroyuki Suzuki, Hidehiro Oku, Taeko Horie, Seita Morishita, Masahiro Tonari, Kazuma Oku, Akiko Okubo, Teruyo Kida, Masashi Mimura, Masanori Fukumoto, Shota Kojima, Shinji Takai, Tsunehiko Ikeda
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 12 Pages: 1-17
- DOI
  10.1371/journal.pone.0114694
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25462763
[Journal Article] Systemic simvastatin rescues retinal ganglion cells from optic nerve injury possibly through suppression of astroglial NF-kappaB activation.2014
- Author(s)
  Morishita S, Oku H, Horie T, Tonari M, Kida T, Okubo A, Sugiyama T, Takai S, Hara H, Ikeda T.
- Journal Title
  
  PLoS One.
  
  Volume: ９ Issue: 1 Pages: e84387-e84387
- DOI
  10.1371/journal.pone.0084387
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462763
[Journal Article] P2X2 receptor activation may be involved in neuronal loss in the retinal ganglion cell layer after acute elevation of intraocular pressure in rats.2014
- Author(s)
  Sugiyama T, Lee SY, Horie T, Oku H, Takai S, Tanioka H, Kuriki Y, Kojima S, Ikeda T.
- Journal Title
  
  Mol Vis.
  
  Volume: 19 Pages: 2080-2091
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592684
[Journal Article] Chymase inhibition improves vascular dysfunction and survival in stroke-prone spontaneously hypertensive rats2014
- Author(s)
  Takai S, Jin D, Chen H, Li W, Yamamotoc H, Yamanishi K, Miyazaki M, Higashino H, Yamanishi H, Okamura H.
- Journal Title
  
  Journal of Hypertension
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590313
[Journal Article] Significance of vascular dipeptidyl peptidase-4 inhibition on vascular protection in Zucker diabetic fatty rats.2014
- Author(s)
  Takai S, Sakonjo H, Jin D.
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 125 Pages: 386-393
- NAID
  130004677797
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590336
[Journal Article] Chymase inhibition improves vascular dysfunction and survival in stroke-prone spontaneously hypertensive rats.2014
- Author(s)
  Takai S, Jin D, Chen H, Li W, Yamamoto H, Yamanishi K, Miyazaki M, Higashino H, Yamanishi H, Okamura H.
- Journal Title
  
  J Hypertens
  
  Volume: 32 Issue: 8 Pages: 1637-1648
- DOI
  10.1097/hjh.0000000000000231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590336
[Journal Article] Pivotal role of mouse mast cell protease 4 in the conversion and pressor properties of big-endothelin-1.2013
- Author(s)
  Houde M, Jamain MD, Labonte J, Desbiens L, Pejler G, Gurish M, Takai S, D'Orleans-Juste P.
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590313
[Journal Article] Significance of matrix metalloproteinase-9 inhibition by imidapril for prevention of abdominal aortic aneurysms in angiotensin II type 1 receptor-knockout mice.2013
- Author(s)
  Takai S, Jin D, Yamamoto D, Li ZL, Otsuki Y, Miyazaki M.
- Journal Title
  
  J Pharmacol Sci.
  
  Volume: 123 Pages: 185-194
- NAID
  130003382588
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590336
[Journal Article] Angiotensin II promotes aortic valve thickening independent of elevated blood pressure I apolipoprotein-E deficientmice2013
- Author(s)
  Tomohiro Fujisaka,Toshiaki Hanafusa,Nobukazu Ishizaka
- Journal Title
  
  Atherosclerosis
  
  Volume: 226(1) Issue: 1 Pages: 82-7
- DOI
  10.1016/j.atherosclerosis.2012.10.055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590770, KAKENHI-PROJECT-24590336
[Journal Article] Chymase inhibition attenuates lipopolysaccharide/ d-galactosamine-induced acute liver failure in hamsters2013
- Author(s)
  Imai Y, Takai S, Jin D, Komeda K, Tashiro K, Li ZL, Otsuki Y, Okamura H, Hayashi M, Uchiyama K.
- Journal Title
  
  Pharmacology
  
  Volume: 40 Issue: 1-2 Pages: 832-840
- DOI
  10.1159/000357684
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590313, KAKENHI-PROJECT-24590336
[Journal Article] Chymase inhibition attenuates monocrotaline-induced sinusoidal obstruction syndrome in hamsters.2013
- Author(s)
  Masubuchi S, Komeda K, Takai S, Jin D, Tashiro K, Li ZL, Otsuki Y, Okamura H, Hayashi M, Uchiyama K
- Journal Title
  
  Curr Med Chem
  
  Volume: 20 Pages: 2723-2729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590336
[Journal Article] P2X(7) receptor activation may be involved in neuronal loss in the retinal ganglion cell layer after acute elevation of intraocular pressure in rats.2013
- Author(s)
  Sugiyama T, Lee SY, Horie T, Oku H, Takai S, Tanioka H, Kuriki Y, Kojima S, Ikeda T.
- Journal Title
  
  Mol Vis.
  
  Volume: １９ Pages: 2080-2091
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462763
[Journal Article] Powerful vascular protection by combining cilnidipine with valsartan in stroke-prone, spontaneously hypertensive rats.2013
- Author(s)
  Takai S, Jin D, Aritomi S, Niinuma K, Miyazaki M.
- Journal Title
  
  Hypertens Res
  
  Volume: 36 Issue: 4 Pages: 342-348
- DOI
  10.1038/hr.2012.187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590336
[Journal Article] Significance of the vascular concentration of angiotensin II-receptor blockers on the mechanism of lowering blood pressure in spontaneously hypertensive rats.2013
- Author(s)
  Takai S, Jin D, Sakonjo H, Takubo T, Nakanishi T.
- Journal Title
  
  J Pharmacol Sci.
  
  Volume: 123 Pages: 371-379
- NAID
  130003382617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590336
[Journal Article] Chymase inhibitor ameliorates hepatic steatosis and fibrosis on established non-alcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet2013
- Author(s)
  Masubuchi S, Takai S, Jin D, Tashiro K, Komeda K, Li ZL, Otsuki Y, Okamura H, Hayashi M, Uchiyama K
- Journal Title
  
  Hepatol Res
  
  Volume: Vol.43、No.9 Pages: 970-978
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590313
[Journal Article] Chymase Inhibition Attenuates Monocrotaline-Induced Sinusoidal Obstruction Syndrome in Hamsters.2013
- Author(s)
  Masubuchi S, Komeda K, Takai S, Jin D, Tashiro K, Li ZL, Otsuki Y, Otsuki Y, Okamura H, Hayashi M, Uchiyama K.
- Journal Title
  
  Curr Med Chem
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590313
[Journal Article] Chymase inhibitor ameliorates hepatic steatosis and fibrosis on established non-alcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet.2013
- Author(s)
  Masubuchi S, Takai S, Jin D, Tashiro K, Komeda K, Li ZL, Otsuki Y, Okamura H, Hayashi M, Uchiyama K.
- Journal Title
  
  Hepatol Res
  
  Volume: 印刷中 Issue: 9 Pages: 970-978
- DOI
  10.1111/hepr.12042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590313, KAKENHI-PROJECT-23591999, KAKENHI-PROJECT-24590336
[Journal Article] Multiple mechanisms for the action of chymase inhibitors.2012
- Author(s)
  Takai S, Jin D, Miyazaki M.
- Journal Title
  
  J Pharmacol Sci.
  
  Volume: 118 Pages: 311-316
- NAID
  10030455328
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590336
[Journal Article] Outside fibroblasts play a key role in the development of inner neointima after the implantation of polytetrafluoroethylene grafts.2012
- Author(s)
  Jin D, Takai S, Li Z, Sakonjo H, Otsuki Y, Shibayama Y, Miyazaki M.
- Journal Title
  
  J Pharmacol Sci.
  
  Volume: 119 Pages: 139-149
- NAID
  10030828453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590336
[Journal Article] Chymase inhibitor ameliorates hepatic steatosis and fibrosis on established non-alcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet2012
- Author(s)
  Masubuchi S, Takai S, Jin D, Tashiro K, Komeda K, Li ZL, Otsuki Y, Okamura H, Hayashi M, Uchiyama K.
- Journal Title
  
  Hepatol Res.
- Data Source
  KAKENHI-PROJECT-23591999
[Journal Article] Cisplati-induced acute renal failure in mice is mediated by chymase-activated angiotensin-aldosterone system and interleukin-182012
- Author(s)
  Shin　Okui
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 685 Issue: 1-3 Pages: 149-155
- DOI
  10.1016/j.ejphar.2012.04.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590251, KAKENHI-PROJECT-23590313, KAKENHI-PROJECT-24390306
[Journal Article] NOX1/NADPH oxidase is involved in endotoxin-induced cardiomyocyte spoptosis.2012
- Author(s)
  Matsuno K, Iwata K, Matsumoto M, Katsuyama M, Cui W, Murata A, Nakamura H, Ibi M, Ikami K, Zhang J, Matoba S, Jin D, Takai S, Matsubara H, Matsuda N, Yabe-Nishimura C
- Journal Title
  
  Free Radic Biol Med
  
  Volume: 53 Issue: 9 Pages: 1718-1728
- DOI
  10.1016/j.freeradbiomed.2012.08.590
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500445, KAKENHI-PROJECT-24590336
[Journal Article] Candesartan and amlodipine combination therapy provides powerful vascular protection in stroke-prone spontaneously hypertensive rats2011
- Author(s)
  Takai, et al
- Journal Title
  
  Hypertens Res
  
  Volume: 34 Pages: 245-252
- NAID
  10031163160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590295
[Journal Article] Candesartan and amlodipine combination therapy provides powerful vascular protection in stroke-prone spontaneously hypertensive rats2011
- Author(s)
  Shinji Takai
- Journal Title
  
  Hypertension Research
  
  Volume: 34 Pages: 245-252
- NAID
  10031163160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590265
[Journal Article] Targets of chymase inhibitors2011
- Author(s)
  Takai S, Jin D, Miyazaki M.
- Journal Title
  
  Expert Opin Ther Targets
  
  Volume: 15 Pages: 519-527
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590295
[Journal Article] Irbesartan prevents metabolic syndrome in rats via activation of peroxisome proliferator-activated receptor γ2011
- Author(s)
  Takai, et al
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 116 Pages: 309-315
- NAID
  10029895295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590295
[Journal Article] Effects of gelatin hydrogel containing chymase inhibitor on scarring in a canine filtration surgery model2011
- Author(s)
  Kojima S, Sugiyama T, Takai S, Jin D, et al.
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 52 Pages: 7672-7680
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590295
[Journal Article] Effects of gelatin hydrogel containing chymase inhibitor on scarring in a canine filtration surgery model2011
- Author(s)
  Kojima S, Sugiyama T, Takai S, et al
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 52 Issue: 10 Pages: 7672-7680
- DOI
  10.1167/iovs.11-7573
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591972
[Journal Article] Targets of chymase inhibitors2011
- Author(s)
  Shinji Takai
- Journal Title
  
  Expert Opinion on Therapeutic Targets
  
  Volume: 15 Pages: 519-527
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590265
[Journal Article] New approaches to blockade of the renin-angiotensin-aldosterone system : chymase as an important target to prevent organ damage.2010
- Author(s)
  Takai, et al
- Journal Title
  
  J Pharmacol Sci.
  
  Volume: 113 Pages: 301-319
- NAID
  10027745795
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590295
[Journal Article] Chymase as an important target for preventing complications of metabolic syndrome.2010
- Author(s)
  Takai, et al
- Journal Title
  
  Curr Med Chem
  
  Volume: 17 Pages: 3223-3229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590295
[Journal Article] Combination therapy with irbesartan and efonidipine for attenuation of proteinuria in Dahl salt-sensitive rats2010
- Author(s)
  Shinji Takai
- Journal Title
  
  Hypertension Research
  
  Volume: 33 Pages: 953-959
- NAID
  10026711303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590265
[Journal Article] Chymase as an important target for preventing complications of metabolic syndrome.2010
- Author(s)
  Takai S, Jin D, Miyazaki M
- Journal Title
  
  Curr Med Chem 17
  
  Pages: 3223-3229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590265
[Journal Article] Chymase as an important target for preventing complications of metabolic syndrome2010
- Author(s)
  Shinji Takai
- Journal Title
  
  Current Medicinal Chemistry
  
  Volume: 17 Pages: 3223-3229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590265
[Journal Article] New approaches to blockade of the renin-angiotensin-aldosterone system : chymase as an important target to prevent organ damage2010
- Author(s)
  Shinji Takai
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 113 Pages: 301-309
- NAID
  10027745795
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590265
[Journal Article] Chymase as an important target for preventing complications of metabolic syndrome2010
- Author(s)
  Takai S, Jin D, Miyazaki M.
- Journal Title
  
  Curr Med Chem
  
  Volume: 17 Pages: 3223-3229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590295
[Journal Article] Combination therapy with irbesartan and efonidipine for attenuation of proteinuria in Dahl salt-sensitive rats.2010
- Author(s)
  Takai, et al
- Journal Title
  
  Hypertens Res
  
  Volume: 33 Pages: 953-959
- NAID
  10026711303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590295
[Journal Article] Anti-atherosclerotic effects of dihomo-gamma-linolenic acid in ApoE-deficient mice2009
- Author(s)
  Takai, et al
- Journal Title
  
  J Atheroscler Thromb 16
  
  Pages: 480-489
- NAID
  130004444309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590295
[Journal Article] Chymase inhibition provides pancreatic islet protection in hamsters with streptozotocin-induced diabetes2009
- Author(s)
  Shinji Takai
- Journal Title
  
  J.Pharmacol.Sci. 110
  
  Pages: 459-465
- NAID
  10025738252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590265
[Journal Article] Long-term angiotensin II blockade may improve not only hyperglycemia but also age-associated cardiac fibrosis.2009
- Author(s)
  Jin D, Takai S, et al
- Journal Title
  
  J Pharmacol Sci 109(2)
  
  Pages: 275-284
- NAID
  10025734617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590265
[Journal Article] Effects of chymase inhibitor on angiotensin II-induced abdominal aortic aneurysm development in apolipoprotein E-deficient mice2009
- Author(s)
  Inoue N, Jin D, Takai S, et al.
- Journal Title
  
  Atherosclerosis
  
  Volume: 204(2) Pages: 359-364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590295
[Journal Article] Chymase-dependent conversion of exogenously administered big endothelin-1 in the mouse in vivo.2009
- Author(s)
  Simard E, Jin D, Takai S, et al
- Journal Title
  
  J Pharmacol Exp Ther 328(2)
  
  Pages: 540-548
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590265
[Journal Article] Significance of angiotensin II receptor blockers with high affinity to angiotensin II type 1 receptors for vascular protection in rats2009
- Author(s)
  Takai, et al
- Journal Title
  
  Hypertens Res 32
  
  Pages: 853-860
- NAID
  10026123657
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590295
[Journal Article] Chymase-dependent conversion of exogenously administered big endothelin-1 in the mouse in vivo2009
- Author(s)
  Simard E, Jin D, Takai S, et al
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 328(2) Pages: 540-548
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590295
[Journal Article] Effects of chymase inhibitor on angiotensin II-induced abdominal aortic aneurysm development in apolipoprotein E-deficient mice.2009
- Author(s)
  Inoue N, Jin D, Takai S, et al
- Journal Title
  
  Atherosclerosis 204(2)
  
  Pages: 359-364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590265
[Journal Article] Anti-atherosclerotic effects of dihomo-γ-linolenic acid in apoE-deficient mice2009
- Author(s)
  Shinji Takai
- Journal Title
  
  J.Atheroscler.Thromb. 16
  
  Pages: 480-488
- NAID
  10025766711
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590265
[Journal Article] Chymase plays an important role in left ventricular remodeling induced by intermittent hypoxia in mice.2009
- Author(s)
  Matsumoto C, Jin D, Takai S, et al
- Journal Title
  
  Hypertension 54(1)
  
  Pages: 164-171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590265
[Journal Article] Chymase inhibition provides pancreatic islet protection in hamsters with streptozotocin-induced diabetes2009
- Author(s)
  Takai, et al
- Journal Title
  
  J Pharmacol Sci 110
  
  Pages: 459-465
- NAID
  10025738252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590295
[Journal Article] Long-term angiotensin II blockade may improve not only hyperglycemia but also age-associated cardiac fibrosis2009
- Author(s)
  Jin D, Takai S, et al.
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 109(2) Pages: 275-284
- NAID
  10025734617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590295
[Journal Article] Chymase inhibitor as a novel therapeutic strategy for anti-vascular remodeling2006
- Author(s)
  Takai S
- Journal Title
  
  Vascular Disease Prevention 3
  
  Pages: 33-39
- Data Source
  KAKENHI-PROJECT-17390070
[Journal Article] Effect of olmesartan medoxomil on atherosclerosis olmesartan medoxomil and atherosclerosis -Clinical implications of the emerging evidence2006
- Author(s)
  Takai S
- Journal Title
  
  American Journal of Cardiovascular Drugs 6
  
  Pages: 363-366
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390070
[Journal Article] Chymase inhibitor as a novel therapeutic strategy for anti-vascular2006
- Author(s)
  Takai S
- Journal Title
  
  Vascular Disease Prevention 3
  
  Pages: 33-39
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390070
[Journal Article] Effect of olmesartan medoxomil on atherosclerosis olmesartan medoxomil and atherosclerosis-Climical implications of the emerging evidence2006
- Author(s)
  Takai S
- Journal Title
  
  American Journal of Cardiovascular Drugs 6
  
  Pages: 363-366
- Data Source
  KAKENHI-PROJECT-17390070
[Journal Article] Effect of olmesartan medoxomil on atherosclerosis olmesartan medoxomil and atherosclerosis-Clinical implications of the emerging evidence2006
- Author(s)
  Takai S
- Journal Title
  
  American Journal of Cardiovascular Drugs 6
  
  Pages: 363-366
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390070
[Journal Article] Chymase inhibitor as a novel therapeutic strategy for antivascular2006
- Author(s)
  Takai S
- Journal Title
  
  Vascular Disease Prevention 3
  
  Pages: 33-39
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390070
[Journal Article] The role of chymase in vascular remodeling and tissue fibrosis2005
- Author(s)
  Takai S
- Journal Title
  
  Curr Hypertens Rev (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370038
[Journal Article] The role of chymase in vascular remodeling and tissue fibrosis2005
- Author(s)
  Takai S
- Journal Title
  
  Curr Hypertens Rev (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590240
[Journal Article] The regressive effect of an angiotensin II receptor blocker on formed fatty streaks in monkeys fed a high-cholesterol diet2005
- Author(s)
  Takai S
- Journal Title
  
  Journal of Hypertension 23(10)
  
  Pages: 1879-1886
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390070
[Journal Article] The regressive effect of an angiotensin II receptor blocker on formed fatty streaks in monkeys fed a high-cholesterol diet2005
- Author(s)
  Takai S
- Journal Title
  
  Journal of Hypertension 23・10
  
  Pages: 1879-1886
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390070
[Journal Article] Eplerenone inhibits atherosclerosis in non-human primates2005
- Author(s)
  Takai S
- Journal Title
  
  Hypertension 46・5
  
  Pages: 1135-1139
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390070
[Journal Article] Inhibition of transforming growth factor-β activation is a novel effect of chymase inactivation2005
- Author(s)
  Takai S
- Journal Title
  
  Letters in Drug Design & Discovery 2
  
  Pages: 19-22
- Data Source
  KAKENHI-PROJECT-17390070
[Journal Article] The regressive effect of an angiotensin II receptor blocker on formed fatty streaks in monkeys fed a high-cholesterol diet2005
- Author(s)
  Takai S
- Journal Title
  
  Journal of Hypertension 23・10
  
  Pages: 1879-1886
- Data Source
  KAKENHI-PROJECT-16659068
[Journal Article] Inhibition of transforming growth factor-β activation is a novel effect of chymase inactivation2005
- Author(s)
  Takai S
- Journal Title
  
  Letters in Drug Design ＆ Discovery 2
  
  Pages: 19-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390070
[Journal Article] Eplerenone inhibits atherosclerosis in non-human primates2005
- Author(s)
  Takai S
- Journal Title
  
  Hypertension 46・5
  
  Pages: 1135-1139
- Data Source
  KAKENHI-PROJECT-16659068
[Journal Article] Significant of angiotensin II receptor blocker lipophilicities and their protective effect against vascular remodeling2005
- Author(s)
  Takai S
- Journal Title
  
  Hypertension Research 28・7
  
  Pages: 593-600
- NAID
  10016904325
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390070
[Journal Article] Development of chymase inhibitor as a potent agent for preventing vascular disease2005
- Author(s)
  Takai S
- Journal Title
  
  International Journal of Pharmacology 1(3)
  
  Pages: 281-286
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390070
[Journal Article] Significant of angiotensin II receptor blocker lipophilicities and their protective effect against vascular remodeling2005
- Author(s)
  Takai S
- Journal Title
  
  Hypertension Research 28(7)
  
  Pages: 593-600
- NAID
  10016904325
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390070
[Journal Article] Eplerenone inhibits atherosclerosis in non-human primates2005
- Author(s)
  Takai S
- Journal Title
  
  Hypertension 46(5)
  
  Pages: 1135-1139
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390070
[Journal Article] Development of chymase inhibitor as a potent agent for preventing vascular disease2005
- Author(s)
  Takai S
- Journal Title
  
  International Journal of Pharmacology 1・3
  
  Pages: 281-286
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390070
[Journal Article] Therapeutic applications of chymase inhibitors in cardiovascular diseases and fibrosis2004
- Author(s)
  Takai S
- Journal Title
  
  European Journal of Pharmacology 501
  
  Pages: 501-508
- Data Source
  KAKENHI-PROJECT-16659068
[Journal Article] Therapeutic applications of chymase inhibitors in cardiovascular disease and fibrosis2004
- Author(s)
  Takai S
- Journal Title
  
  Eur J Pharmacol 501
  
  Pages: 1-8
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590240
[Journal Article] Significant target organs for hypertension and cardiac hypertrophy by angiotensin-converting enzyme inhibitors2004
- Author(s)
  Takai S
- Journal Title
  
  Hypertens Res 27
  
  Pages: 213-219
- NAID
  10012844010
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370038
[Journal Article] Chymase as a novel target for prevention of vascular diseases2004
- Author(s)
  Takai S
- Journal Title
  
  Trends Pharmacol Sci 25
  
  Pages: 518-522
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370038
[Journal Article] A single treatment with a specific chymase inhibitor, TY-51184,prevrnts vascular proliferation in canin grafted veins2004
- Author(s)
  Takai S
- Journal Title
  
  J Pharmacol Sci 94
  
  Pages: 443-448
- Data Source
  KAKENHI-PROJECT-14370038
[Journal Article] Therapeutic applications of chymase inhibitors in cardiovascular disease and fibrosis2004
- Author(s)
  Takai S
- Journal Title
  
  Eur J Pharmacol 501
  
  Pages: 1-8
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370038
[Journal Article] A single treatment with a specific chymase inhibitor, TY-51184, prevents vascular proliferation in canine grafted veins2004
- Author(s)
  Takai S
- Journal Title
  
  J Pharmacol Sci 94
  
  Pages: 443-448
- NAID
  10012892021
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370038
[Journal Article] Significant target organs for hypertension and cardiac hypertrophy by angiotensin-converting enzyme inhibitors.2004
- Author(s)
  Takai S
- Journal Title
  
  Hypertens Res. 27
  
  Pages: 213-219
- NAID
  10012844010
- Data Source
  KAKENHI-PROJECT-15590240
[Journal Article] Therapeutic applications of chymase inhibitors in cardiovascular disease and fibrosis2004
- Author(s)
  Takai S
- Journal Title
  
  Fur J Phamacol 501
  
  Pages: 1-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590240
[Journal Article] Chymase as a novel target for the prevention of vascular diseases.2004
- Author(s)
  Takai S
- Journal Title
  
  Trends Pharmacol Sci. 25
  
  Pages: 518-522
- Data Source
  KAKENHI-PROJECT-15590240
[Journal Article] Comparative effects of candesartan and amlodipine in a monkey atherosclerotic model2004
- Author(s)
  Takai S
- Journal Title
  
  Hypertens Res 27
  
  Pages: 517-522
- NAID
  10013515786
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370038
[Journal Article] Comparative effects of candesartan and amlodipine in a monkey atherosclerotic model2004
- Author(s)
  Takai S
- Journal Title
  
  Hypertension Research 27・7
  
  Pages: 517-522
- NAID
  10013515786
- Data Source
  KAKENHI-PROJECT-16659068
[Journal Article] Therapeutic applications of chymase inhibitors in cardiovascular disease and fibrosis2004
- Author(s)
  Takai S
- Journal Title
  
  Eur J Pharmacol 201
  
  Pages: 1-8
- Data Source
  KAKENHI-PROJECT-14370038
[Journal Article] Comparative effects of candesartan and amlodipine in a monkey atherosclerotic model2004
- Author(s)
  Takai S
- Journal Title
  
  Hypertens Res 27
  
  Pages: 517-522
- NAID
  10013515786
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590240
[Journal Article] Significant target organs for hypertension and cardiac hypertrophy by angiotensin-converting enzyme inhibitors2004
- Author(s)
  Takai S
- Journal Title
  
  Hypertens Res 27
  
  Pages: 213-219
- NAID
  10012844010
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590240
[Journal Article] Chymase as a novel target for prevention of vascular diseases2004
- Author(s)
  Takai S
- Journal Title
  
  Trends in Pharmacological Sciences 25・10
  
  Pages: 518-522
- Data Source
  KAKENHI-PROJECT-16659068
[Journal Article] Therapeutic applications of chymase inhibitors in cardiovascular diseases and fibrosis.2004
- Author(s)
  Takai S
- Journal Title
  
  Eur J Pharmacol. 501
  
  Pages: 1-8
- Data Source
  KAKENHI-PROJECT-15590240
[Journal Article] Chymase as a novel target for prevention of vascular diseases2004
- Author(s)
  Takai S
- Journal Title
  
  Trends Pharmacol Sci 25
  
  Pages: 518-522
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590240
[Journal Article] A single treatment with a specific chymase inhibitor, TY-51184, prevents vascular proliferation in canine grafted veins2004
- Author(s)
  Takai S
- Journal Title
  
  J Pharmacol Sci 94
  
  Pages: 443-448
- NAID
  10012892021
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590240
[Journal Article] Mechanisms of angiotensin II type 1 receptor blocker for antiatherosclerotic effect in monkeys fed a high-cholesterol diet2003
- Author(s)
  Takai S
- Journal Title
  
  J Hypertens 21
  
  Pages: 417-420
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370038
[Journal Article] A novel chymase inhibitor 4-[1-{[bis-(4-methyl-phenyl)-methyl]-carbamoyl}-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy]-benzoic acid (BCEAB) suppressed cardiac fibrosis in cardiomyopathic hamsters2003
- Author(s)
  Takai S
- Journal Title
  
  J Pharmacol Exp Ther 305
  
  Pages: 17-23
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370038
[Journal Article] A single treatment with a specific chymase inhibitor, TY-51184, prevents vascular proliferation in canin grafted veins2003
- Author(s)
  Takai S
- Journal Title
  
  J Pharmacol Sci 94
  
  Pages: 443-448
- NAID
  10012892021
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590240
[Journal Article] A novel chymase inhibitor, 4-[1-{[bis-(4-methyl-phenyl)-methyl]-carbamoyl}-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy]-benzoic acid (BCEAB) suppressed cardiac fibrosis in cardiomyopathic hamsters2003
- Author(s)
  Takai S
- Journal Title
  
  J Pharmacol Exp Ther 305
  
  Pages: 17-23
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370038
[Journal Article] A novel chymase inhibitor, 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[{3,4-dioxo-1-phenyl-7-(2-pyridyloxy)}-2-heptyl] acetamide (NK3201), suppressed intimal hyperplasia after balloon injury2003
- Author(s)
  Takai S
- Journal Title
  
  J Pharmacol Exp Ther 304
  
  Pages: 841-844
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370038
[Journal Article] A novel chymase inhibitor 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N[{3,4-dioxo-1-phenyl-7-(2-pyridyloxy)}-2-heptyl] acetamide (NK3201), suppressed intimal hyperplasia after balloon injury2003
- Author(s)
  Takai S
- Journal Title
  
  J Pharmacol Exp Ther 304
  
  Pages: 841-844
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370038
[Journal Article] Application of a chymase inhibitor, NK3201, for prevention of vascular proliferation2003
- Author(s)
  Takai S
- Journal Title
  
  Cardiovasc Drug Rev 25
  
  Pages: 185-198
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370038
[Journal Article] A novel therapeutic strategy against vascular disorders with chymase inhibitor2003
- Author(s)
  Takai S
- Journal Title
  
  Curr Vasc Pharmacol 1
  
  Pages: 217-224
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370038
[Journal Article] Application of a chymase inhibitor, NK3201, for prevention of vascular proliferation2003
- Author(s)
  Takai S
- Journal Title
  
  Cardiovasc Drug Rev 21
  
  Pages: 185-198
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370038
[Journal Article] The role of chymase in vascular proliferation2002
- Author(s)
  Takai S
- Journal Title
  
  Drug News Perspect 15
  
  Pages: 278-282
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370038
[Journal Article] Chymase inhibition improves vascular dysfunction and survival in stroke-prone spontaneously hypertensive rats
- Author(s)
  Takai S, Jin D, Chen H, Li W, Yamamoto H, Yamanishi K, MiyazakiM, Higashino H, Yamanishi H, Okamura H
- Journal Title
  
  J Hypetens
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590313
[Journal Article] Outside fibroblasts play a key role in the development of Inner neointima after the implantation of polytetrafluoroethylene grafts
- Author(s)
  Jin D, Takai S, Li Z, et al.
- Journal Title
  
  J Pharmacol Sci
  
  Volume: (in press)
- NAID
  10030828453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590295
[Presentation] 腎虚血再灌流モデルラットを用いた急性腎障害回復過程におけるバイオマーカー評価2021
- Author(s)
  細畑圭子、金徳男、髙井真司、岩永一範
- Organizer
  第26回日本病態プロテアーゼ学会
- Data Source
  KAKENHI-PROJECT-21K06722
[Presentation] 腎虚血再灌流モデルにおける腎障害バイオマーカーの挙動評価2021
- Author(s)
  細畑圭子、金徳男、髙井真司、岩永一範
- Organizer
  第99階日本生理学会大会
- Data Source
  KAKENHI-PROJECT-21K06722
[Presentation] 腎虚血再灌流モデルラットを用いた腎障害バイオマーカーの挙動評価2021
- Author(s)
  細畑圭子、金徳男、髙井真司、岩永一範
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K06722
[Presentation] Dahl salt-sensitive ratを用いた近位尿細管障害におけるvanin-1の関与2020
- Author(s)
  細畑圭子、金徳男、高井真司、岩永一範
- Organizer
  日本薬理学会
- Data Source
  KAKENHI-PROJECT-18K06768
[Presentation] 生分解性インジェクタブルポリマーゲル内での脂肪由来幹細胞の未分化能保持2019
- Author(s)
  眞弓のぞみ, 能﨑優太, 髙井宏樹, 伊井正明, 大矢裕一
- Organizer
  第68回高分子学会年次大会
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] Urinary vanin-1 reflects an ameliorating effect for oxidative renal tubular injury in Dahl-salt sensitive rats2019
- Author(s)
  Hosohata K, Jin D, Takai S, Iwanaga K.
- Organizer
  Complex Cardiovascular Therapeutics 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06768
[Presentation] Biodegradable Injectable Polymer Systems Exhibiting Irreversible Gelation for Biomedical Applications2019
- Author(s)
  Yuichi Ohya, Yuta Yoshizaki, Yasuyuki Yoshida, Kazuyuki Takata, Takuya Nagata, Hiroki Takai, Denan Jin, Akinori Kuzuya
- Organizer
  KUMP International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] Adipose-derived stem cell delivery system using temperature-responsive biodegradable injectable hydrogel2019
- Author(s)
  Y. Yoshizaki, H. Takai, S. Fujiwara, M. Ii, H. Uchida, S. Nemoto, A. Kuzuya, Y. Ohya
- Organizer
  ACS National Meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] 温度応答型生分解性インジェクタブルゲルを用いた内視鏡下で使用可能な癒着防止剤の開発2019
- Author(s)
  永田拓也, 藤原壮一郎, 能﨑優太, 髙井真司, 金徳男, 葛谷明紀, 大矢裕一
- Organizer
  第23回関西大学先端科学技術シンポジウム
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] Temperature-responsive Biodegradable Injectable Hydrogel for Adhesion Prevention Materials2019
- Author(s)
  Y. Ohya, T. Nagata, Y. Yoshizaki, S. Fujiwara, S. Takai, D. Jin, A. Kuzuya
- Organizer
  30th Annual Conference of the European Society for Biomaterial
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] Dahl salt-sensitive ratにおける酸化ストレスを介した腎尿細管障害進展とvanin-1の関与2019
- Author(s)
  細畑圭子、金　徳男、高井真司、岩永一範.
- Organizer
  第29回日本循環薬理学会
- Data Source
  KAKENHI-PROJECT-18K06768
[Presentation] Biodegradable Injectable Polymer Systems Exhibiting Temperature-Responsive Irreversible Sol-Gel Transition for Medical Application2019
- Author(s)
  Y. Ohya, Y. Yoshizaki, S. Fujiwara, T. Nagata, H. Takai, Y. Yoshida, K. Takata, A. Kuzuya
- Organizer
  OKINAWA COLLOIDS 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] Adipose Derived Stem Cell Delivery System Using Temperature-responsive Biodegradable Injectable Hydrogels2019
- Author(s)
  Yuta Yoshizaki, Hiroki Takai, Soichiro Fujiwara, Masaaki Ii, Hiroaki Uchida, Shintaro Nemoto, Akinori Kuzuya, Yuichi Ohya
- Organizer
  ACS National Meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] 虚血性心疾患に対する温度応答型生分解性インジェクタブルゲルを用いた脂肪由来幹細胞デリバリー2019
- Author(s)
  能﨑優太, 髙井宏樹, 藤原壮一郎, 伊井正明, 打田裕明, 根本慎太郎, 葛谷明紀, 大矢裕一
- Organizer
  第18回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] 生分解性インジェクタブルポリマーゲル内で培養した脂肪由来幹細胞の未分化能保持2019
- Author(s)
  眞弓のぞみ, 能﨑優太, 髙井宏樹, 藤原壮一郎, 伊井正明, 葛谷明紀, 大矢裕一
- Organizer
  第65回高分子研究発表会(神戸)
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] Biodegradable Irreversible Thermo-gelling Polymer Systems for Drug Delivery and Other Medical Applications2019
- Author(s)
  Yuichi Ohya, Yuta Yoshizaki, Takuya Nagata, Hiroki Takai, Yasuyuki Yoshida, Kazuyuki Takata, Akinori Kuzuya
- Organizer
  ACS National Meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] 温度応答型生分解性インジェクタブルヒドロゲル内での脂肪由来幹細胞の未分化性保持2019
- Author(s)
  眞弓のぞみ, 能﨑優太, 髙井宏樹, 藤原壮一郎, 伊井正明, 大矢裕一
- Organizer
  第48回医用高分子シンポジウム
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] 温度応答型生分解性インジェクタブルゲル内での脂肪由来幹細胞の多能性保持と細胞デリバリーシステムへの応用2019
- Author(s)
  眞弓のぞみ, 能﨑優太, 高井宏樹, 藤原壮一郎, 大矢裕一
- Organizer
  第68回高分子討論会
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] Adipose-derived Stem Cell Therapy with Temperature-sensitive Biodegradable Injectable Gel for Myocardial Infarction2019
- Author(s)
  Masaaki Ii, Yuta Yoshizaki, Hiroki Takai, Akinori Kuzuya, Yuichi Ohya, Hiroaki Uchida, Shintaro Nemoto
- Organizer
  第83回日本循環器学会学術集会（JCS2019）
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] Degradable Injectable Themo-gelling Polymers for Adhesion Prevention2019
- Author(s)
  Y. Ohya, T. Nagata, Y. Yoshizaki, S. Fujiwara, S. Takai, D. Jin, A. Kuzuya
- Organizer
  TERMIS-AP + ABMC7 2019 Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] The alterations of a tubular epithelial marker in a rat model of hydronephrosis2019
- Author(s)
  Hosohata K, Jin D, Takai S, Iwanaga K.
- Organizer
  TEMTIX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06768
[Presentation] Dahl食塩感受性高血圧ラットにおける腎尿細管障害の治療効果を反映するバイオマーカーの検討2019
- Author(s)
  細畑　圭子、金　徳男、高井　真司、岩永　一範
- Organizer
  第40回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-18K06768
[Presentation] 温度応答型生分解性インジェクタブルポリマーの癒着防止材への応用2019
- Author(s)
  能﨑優太, 永田拓也, 藤原壮一郎, 髙井真司, 金徳男, 葛谷明紀, 大矢裕一
- Organizer
  第48回医用高分子シンポジウム
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] Cellular Delivery System Using Temperature-responsive Biodegradable Injectable Hydrogels for Ischemic Heart Diseases2019
- Author(s)
  Yuta Yoshizaki, Hiroki Takai, Soichiro Fujiwara, Masaaki Ii, Hiroaki Uchida, Shintaro Nemoto, Akinori Kuzuya, Yuichi Ohya
- Organizer
  KUMP International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] Biodegradable Injectable Thermo-gelling Polymer Systems with Longer and Controllable Duration Time of Gel State2018
- Author(s)
  Yuichi Ohya, Yasuyuki Yoshida, Keisuke Kawahara, Kazuyuki Takada, Takuya Nagata, Hiroki Takai, Yuta Yoshizaki, Akinori Kuzuya
- Organizer
  Society for Biomaterials 2018 Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] Bursa premacularisにおけるセリンプロテアーゼの発現2018
- Author(s)
  佐藤孝樹，福本雅格，喜田照代，堀江妙子，奥　英弘，池田恒彦，高井真司，金　徳男，中村公俊
- Organizer
  第122回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-15K10910
[Presentation] 生分解性インジェクタブルポリマーを用いた脂肪由来幹細胞の局所投与による虚血性心疾患治療2018
- Author(s)
  能﨑優太, 髙井宏樹, 藤原壮一郎, 伊井正明, 打田裕明, 根本慎太郎, 葛谷明紀, 大矢裕一
- Organizer
  第40回日本バイオマテリアル学会大会
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] Evaluation of Temperature-responsive Biodegradable Injectable Hydrogel as Adhesion Prevention Materials2018
- Author(s)
  Takuya Nagata, Soichiro Fujiwara, Yuta Yoshizaki, Shinji Takai, Denan Jin, Akinori Kuzuya, Yuichi Ohya
- Organizer
  The 12th International Polymer Conference (IPC2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] 温度応答型生分解性インジェクタブルポリマーによる幹細胞デリバリーシステム2018
- Author(s)
  能崎優太, 髙井宏樹, 吉田泰之, 伊井正明, 葛谷明紀, 大矢裕一
- Organizer
  第47回医用高分子シンポジウム
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] Biodegradable Injectable Polymer Systems Exhibiting Temperature-responsive Covalent Gelation for Medical Application2018
- Author(s)
  Yuichi Ohya, Yuta Yoshizaki, Takuya Nagata, Hiroki Takai,Yasuyuki Yoshida, Kazuyuki Takata, Akinori Kuzuya
- Organizer
  The 12th International Polymer Conference (IPC2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] An antichymase RNA aptamer improved cardiac function in experimental heart failure.2018
- Author(s)
  Jin D, Takai S, Nonaka Y, Yamazaki S, Fujiwara M, Nakamura Y.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06709
[Presentation] 新規RNAアプタマーによるキマーゼ阻害と心筋梗塞後の心機能および生存率の改善効果2018
- Author(s)
  金徳男、髙井真司、野中洋介、山﨑聡子、藤原将寿、中村義一
- Organizer
  第23回日本病態プロテアーゼ学会
- Data Source
  KAKENHI-PROJECT-18K06709
[Presentation] Muller cell coneの免疫組織学的検討2018
- Author(s)
  池田恒彦，中村公俊，奥　英弘，堀江妙子，喜田照代，高井真司
- Organizer
  第122回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-15K10910
[Presentation] 共有結合ゲルを形成する温度応答型生分解性インジェクタブルポリマーの癒着防止材としての評価2018
- Author(s)
  永田拓也, 藤原壮一郎, 能﨑優太, 髙井真司, 金徳男, 葛谷明紀, 大矢裕一
- Organizer
  第47回医用高分子シンポジウム
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] Biodegradable Injectable Polymer Systems Exhibiting Temperature-responsive Injectable Gelation for Medical Application2018
- Author(s)
  Yuichi Ohya, Yasuyuki Yoshida, Kazuyuki Takada, Takuya Nagata, Hiroki Takai, Hiroki Yamamoto, Yuta Yoshizaki, Akinori Kuzuya
- Organizer
  14th Japan -Belgium Symposium on Polymer Science
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] 虚血組織再生を意図した温度応答型生分解性インジェクタブルポリマーを用いた脂肪由来幹細胞デリバリーシステムの開発2018
- Author(s)
  能﨑優太, 髙井宏樹, 藤原壮一郎, 伊井正明, 打田裕明, 根本慎太郎, 葛谷明紀, 大矢裕一
- Organizer
  日本バイオマテリアル学会関西ブロック第13回若手研究発表会
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] 腹腔鏡手術で使用可能な生分解性癒着防止材の開発2018
- Author(s)
  永田拓也, 藤原壮一郎, 吉田泰之, 能﨑優太, 髙井真司, 金徳男, 葛谷明紀, 大矢裕一
- Organizer
  日本バイオマテリアル学会関西ブロック第13回若手研究発表会
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] 虚血性心疾患の治療を意図した温度応答型生分解性インジェクタブルヒドロゲルの脂肪由来幹細胞デリバリー2018
- Author(s)
  能﨑優太, 髙井宏樹, 藤原壮一郎, 伊井正明, 打田裕明, 根本慎太郎, 葛谷明紀, 大矢裕一
- Organizer
  第67回高分子討論会
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] 心疾患治療への応用を意図した温度応答型生分解性インジェクタブルポリマーによる脂肪由来幹細胞デリバリー2018
- Author(s)
  能崎優太, 髙井宏樹, 吉田泰之, 伊井正明, 葛谷明紀, 大矢裕一
- Organizer
  第34回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] Temperature-responsive Biodegradable Injectable Polymer Hydrogels for Adipose Derived Stem Cell Delivery to Ischemic Heart Tissues2018
- Author(s)
  Yuta Yoshizaki, Hiroki Takai, Soichiro Fujiwara, Masaaki Ii, Hiroaki Uchida, Shintaro Nemoto, Akinori Kuzuya, Yuichi Ohya
- Organizer
  The 12th International Polymer Conference (IPC2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] 脂肪由来肝細胞デリバリーを意図した生分解性インジェクタブルゲルの作成2017
- Author(s)
  髙井宏樹
- Organizer
  第21回関西大学先端科学技術シンポジウム
- Place of Presentation
  関西大学（大阪府）
- Year and Date
  2017-01-19
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] 幹細胞デリバリーを意図した温度応答型生分解性インジェクタブルヒドロゲルの細胞適合性2017
- Author(s)
  髙井宏樹
- Organizer
  第66回高分子討論会
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] 温度応答型生分解性インジェクタブルポリマーを用いた幹細胞デリバリー2017
- Author(s)
  髙井宏樹
- Organizer
  第39回日本バイオマテリアル学会大会
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] 細胞デリバリーを目指した温度応答型生分解性インジェクタブルヒドロゲル内での脂肪由来幹細胞培養2017
- Author(s)
  髙井宏樹
- Organizer
  第66回高分子学会年次大会
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] 温度応答型生分解性インジェクタブルポリマーを用いた幹細胞デリバリーシステムの開発2017
- Author(s)
  髙井宏樹
- Organizer
  日本バイオマテリアル学会関西ブロック　第12回若手研究発表会
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] 網膜硝子体疾患における硝子体と血清中トリプターゼ活性の比較2017
- Author(s)
  佐藤孝樹，福本雅格，河本良輔，小林崇俊，喜田照代，堀江孝子，奥英弘，池田恒彦，高井真司，金徳男，中村公俊
- Organizer
  第121回日本眼科学会総会
- Place of Presentation
  国際フォーラム（東京都千代田区)
- Year and Date
  2017-04-06
- Data Source
  KAKENHI-PROJECT-15K10910
[Presentation] 細胞デリバリーシステムへの応用を意図した温度応答型生分解性インジェクタブルヒドロゲル内での脂肪由来幹細胞培養2017
- Author(s)
  髙井宏樹
- Organizer
  日本バイオマテリアル学会北陸信越ブロック第6回若手研究発表会
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] サル眼の黄斑部網膜におけるニューロン分化機構2017
- Author(s)
  池田恒彦，奥英弘，堀江妙子，喜田照代，高井真司，中村公俊
- Organizer
  第121回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-15K10910
[Presentation] 温度応答型生分解性インジェクタブルヒドロゲルを利用した脂肪由来幹細胞デリバリー2017
- Author(s)
  髙井宏樹
- Organizer
  第63回高分子研究発表会(神戸)
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] Chymase inhibitor prevents the development and progression of non-alcoholic steatohepatitis in rats fed a high-fat and high-cholesterol diet.2017
- Author(s)
  Miyaoka Y, Jin D, Tashiro K, Komeda K, Masubuchi S, Hirokawa F, Hayashi M, Takai S, Uchiyama K.
- Organizer
  Digestive Disease Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08251
[Presentation] 温度応答型生分解性インジェクタブルヒドロゲル内での細胞挙動2016
- Author(s)
  髙井宏樹
- Organizer
  日本バイオマテリアル学会第11 回関西若手研究発表会
- Place of Presentation
  神戸大学（兵庫県）
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] ブロック共重合体型温度応答性生分解性インジェクタブルポリマーの構造物性相関に関する体系的考察2016
- Author(s)
  髙井宏樹
- Organizer
  第65回高分子学会年次大会
- Place of Presentation
  神戸国際会議場（兵庫県）
- Year and Date
  2016-05-25
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] サル眼の黄斑部網膜におけるニューロン分化機構2016
- Author(s)
  池田恒彦, 奥英弘, 堀江妙子, 喜田照代,　高井真司,中村公俊
- Organizer
  第9回RRM
- Place of Presentation
  JPタワーホール＆カンファレンス（東京都千代田区）
- Year and Date
  2016-12-10
- Data Source
  KAKENHI-PROJECT-15K10910
[Presentation] 非アルコール性脂肪性肝炎に対するキマーゼ阻害薬の有用性2016
- Author(s)
  宮岡雄太、金徳男、田代圭太郎、米田浩二、廣川文鋭、林道廣、髙井真司、内山和久
- Organizer
  第130回日本薬理学会近畿部会
- Place of Presentation
  京都大学百周年時計台記念館（京都府京都市）
- Year and Date
  2016-11-19
- Data Source
  KAKENHI-PROJECT-15K08251
[Presentation] 2.Effect of recombinant human soluble thrombomodulin in lipopolysaccharide/D-galactosamine-induced acute liver failure in mice2016
- Author(s)
  Osumi W, Jin D, Imai Y, Miyaoka Y, Tashiro K, Komeda K ,Hirokawa F, Hayashi M, Takai S, Nishiguchi K, Uchiyama K.
- Organizer
  Digestive Disease Week 2016
- Place of Presentation
  サンディエゴ（米国）
- Year and Date
  2016-05-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08251
[Presentation] Cellular Behavior in Biodegradable Injectable Hydrogel for Tissue Engineering2016
- Author(s)
  Hiroki Takai
- Organizer
  The 11th International Symposium in Science and Technology at Kansai University
- Place of Presentation
  Kansai University, Osaka, Japan
- Year and Date
  2016-07-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01854
[Presentation] 非アルコール性脂肪性肝炎におけるキマーゼ阻害薬の重要性2016
- Author(s)
  宮岡雄太、金徳男、田代圭太郎、米田浩二、廣川文鋭、林道廣、髙井真司、内山和久
- Organizer
  第21回日本病態プロテアーゼ学会　2016年8月5-6日
- Place of Presentation
  千里ライフサイエンスセンター（大阪府吹田市）
- Year and Date
  2016-08-05
- Data Source
  KAKENHI-PROJECT-15K08251
[Presentation] 特発性黄斑上膜の病態におけるトリプターゼと2型コラーゲン抗体の関与．2015
- Author(s)
  池田恒彦, 森下清太, 福本雅格, 鈴木浩之, 喜田照代, 奥　英弘,中村公俊, 高井真司
- Organizer
  第119回日本眼科学会総会
- Place of Presentation
  ロイトン札幌(北海道札幌市中央区)
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-15K10910
[Presentation] 特発性黄斑上膜の病態におけるトリプターゼと2型コラーゲンの関与2015
- Author(s)
  池田恒彦, 森下清太, 福本雅格, 鈴木浩之, 喜田照代, 奥英弘, 中村公俊,高井真司
- Organizer
  第８回レチナ・リサーチミーティング
- Place of Presentation
  JPタワーホール＆カンファレンス(東京都千代田区)
- Year and Date
  2015-10-31
- Data Source
  KAKENHI-PROJECT-15K10910
[Presentation] マイトマイシンC(MMC)包含 Gelatin Hydrogelの緑内障濾過手術への応用:MMC単独との比較2014
- Author(s)
  小嶌祥太、杉山哲也、金徳男、高井真司、植木麻理、池田恒彦、田畑靖彦
- Organizer
  第118回日本眼科学会総会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-24592684
[Presentation] 脳卒中易発性高血圧自然発症ラットの血管障害および生存期間に対するキマーゼ阻害薬の効果2013
- Author(s)
  高井真司、金徳男、陳紅、李文、山本英幸、山西恭輔、宮崎瑞夫、岡村春樹
- Organizer
  第36回日本高血圧学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23590313
[Presentation] ＰＴＦＥ人工血管移植後の血管周囲線維芽細胞の遊走とその管腔内内膜肥厚の形成2013
- Author(s)
  金　徳男、高井　真司、宮崎　瑞夫
- Organizer
  第４２回日本心脈管作動物質学会
- Place of Presentation
  奈良県新公会堂（奈良県）
- Data Source
  KAKENHI-PROJECT-24590336
[Presentation] ＰＴＦＥ人工血管移植後の血管内膜肥厚における外膜側線維芽細胞の役割2013
- Author(s)
  金　徳男、高井　真司、宮崎　瑞夫
- Organizer
  第８６回　日本薬理学会年会
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-24590336
[Presentation] 脳卒中易発性高血圧自然発症ラットの血管障害におけるキマーゼの役割2013
- Author(s)
  髙井真司, 金徳男, 陳紅, 李文, 山本英幸, 山西恭輔, 宮崎瑞夫, 山西博道, 岡村春樹
- Organizer
  第36回日本高血圧学会総会
- Place of Presentation
  大阪
- Year and Date
  2013-10-25
- Data Source
  KAKENHI-PROJECT-23590313
[Presentation] 脳卒中易発性高血圧自然発症ラットの血管障害におけるキマーゼの役割2013
- Author(s)
  高井真司、金徳男、陳紅、李文、山本英幸、山西恭輔、宮崎瑞夫、岡村春樹
- Organizer
  第124回日本薬理学会近畿部会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23590313
[Presentation] 脳卒中易発性高血圧自然発症ラットの血管障害に対するキマーゼ阻害薬の効果2013
- Author(s)
  髙井真司, 金徳男, 陳紅, 李文, 山本英幸, 山西恭輔, 宮崎瑞夫, 山西博道, 岡村春樹
- Organizer
  第124回日本薬理学会近畿部会
- Place of Presentation
  京都
- Year and Date
  2013-11-01
- Data Source
  KAKENHI-PROJECT-23590313
[Presentation] 1. A chymase inhibitor, ty-51469, ameliorates already formed hepatic steatosis and fibrosis in a hamster nonalcoholic steatohepatitis (nash) model.2012
- Author(s)
  Masubuchi S, Takai S, Jin D, Tashiro K, Komeda K, Hayashi M, Uchiyama K.
- Organizer
  63th Annual meeting of American Association for the Study of Liver Diseases
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23590313
[Presentation] ハムスターNASHモデルに対するキマーゼ阻害薬の治療効果の検討2012
- Author(s)
  鱒渕真介、高井真司、金徳男、米田浩二、林道廣、内山和久
- Organizer
  第17回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  浜松市
- Year and Date
  2012-08-10
- Data Source
  KAKENHI-PROJECT-23591999
[Presentation] A chymase inhibitor, ty-51469, ameliorates already formed hepatic steatosis and fibrosis in a hamster nonalcoholic steatohepatitis (nash) model2012
- Author(s)
  Masubuchi S, Takai S, Jin D, Tashiro K, Komeda K, Hayashi M, Uchiyama K
- Organizer
  63th Annual meeting of American Association for the Study of Liver Diseases
- Place of Presentation
  ボストン(米国)
- Year and Date
  2012-11-09
- Data Source
  KAKENHI-PROJECT-23590313
[Presentation] A chymase inhibitor,TY-51469,ameliorates already formed hepatic steatosis and fibrosis in a hamster nonalcoholic steatohepatitis(NASH)model2012
- Author(s)
  Shinsuke Masubuchi, Shinji Takai, Denan Jin, Keitaro Tashiro, Koji Komeda, Michihiro Hayashi, Kazuhisa Uchiyama
- Organizer
  63rd Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Boston(U.S.A.)
- Year and Date
  2012-11-12
- Data Source
  KAKENHI-PROJECT-23591999
[Presentation] ハムスターNASHモデルに対するキマーゼ阻害薬の治療効果の検討2012
- Author(s)
  鱒渕真介、髙井真司、金徳男、田代圭太郎、米田浩二、林道廣、内山和久
- Organizer
  第17回日本病態プロテアーゼ学会
- Place of Presentation
  浜松、静岡県
- Data Source
  KAKENHI-PROJECT-23590313
[Presentation] Chymase as a useful target to prevent abdominal aortic aneurysm2011
- Author(s)
  Shinji Takai
- Organizer
  Keystone Symposia
- Place of Presentation
  Granlibakken Ressort (California, USA)
- Year and Date
  2011-01-26
- Data Source
  KAKENHI-PROJECT-20590265
[Presentation] Chymase as a useful target to prevent abdominal aortic aneurysm.2011
- Author(s)
  Takai S, Jin D, Miyazaki M
- Organizer
  Keystone Symposia
- Place of Presentation
  リノ、米国
- Year and Date
  2011-01-26
- Data Source
  KAKENHI-PROJECT-20590265
[Presentation] Chymase as a useful target to prevent abdominal aortic aneurysm2011
- Author(s)
  Takai S, Jin D, Miyazaki M.
- Organizer
  Keystone Symposia
- Place of Presentation
  リノ、米国
- Year and Date
  2011-01-26
- Data Source
  KAKENHI-PROJECT-21590295
[Presentation] キマーゼ阻害薬による腹部大動脈瘤進展予防の可能性(シンポジウム)2010
- Author(s)
  高井真司、金徳男、宮崎瑞夫
- Organizer
  第38回薬物活性シンポジウム
- Place of Presentation
  札幌
- Year and Date
  2010-11-11
- Data Source
  KAKENHI-PROJECT-21590295
[Presentation] Combination therapy with angiotensin receptor blocker and T- and L-type calcium channel blocker for attenuation of proteinuria in Dahl-salt sentitive rats.2010
- Author(s)
  高井真司, 金徳男, et al
- Organizer
  23rd Scientific Meeting of the International Society of Hypertension
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PROJECT-20590265
[Presentation] キマーゼ阻害薬のターゲット疾患について(シンポジウム)2010
- Author(s)
  高井真司、金徳男、宮崎瑞夫
- Organizer
  第15回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2010-08-20
- Data Source
  KAKENHI-PROJECT-20590265
[Presentation] キマーゼ阻害薬のターゲット疾患について(シンポジウム)2010
- Author(s)
  高井真司、金徳男、宮崎瑞夫
- Organizer
  第15回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2010-08-20
- Data Source
  KAKENHI-PROJECT-21590295
[Presentation] カンデサルタンとアムロジピンの併用投与による血管保護相乗効果の機序2010
- Author(s)
  高井真司
- Organizer
  日本高血圧学会
- Place of Presentation
  福岡国際会議場(福岡)
- Year and Date
  2010-10-15
- Data Source
  KAKENHI-PROJECT-20590265
[Presentation] Combination therapy with angiotensin receptor blocker and T-and L-type calcium channel blocker for attenuation of proteinuria in Dahl-salt sentitive rats2010
- Author(s)
  Takai S, Jin D, et al.
- Organizer
  23rd Scientific Meeting of the International Society of Hypertension
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PROJECT-21590295
[Presentation] キマーゼ阻害薬による腹部大動脈瘤予防の可能性2010
- Author(s)
  高井真司
- Organizer
  第38回薬物活性シンポジウム
- Place of Presentation
  札幌市教育文化会館(北海道)
- Year and Date
  2010-11-12
- Data Source
  KAKENHI-PROJECT-20590265
[Presentation] キマーゼ阻害薬による腹部大動脈瘤の進展抑制2010
- Author(s)
  高井真司
- Organizer
  生体機能と創薬シンポジウム2010京都
- Place of Presentation
  ホテルグランビア京都(京都)(招待講演)
- Year and Date
  2010-09-09
- Data Source
  KAKENHI-PROJECT-20590265
[Presentation] Combination therapy with angiotensin receptor blocker and T- and L-type calcium channel blocker for attenuation of proteinuria in Dahlsalt-sensitive rats2010
- Author(s)
  Shinji Takai
- Organizer
  23rd Scientific Meeting of the International Society of Hypertension
- Place of Presentation
  Vancouver Convention Centre (Vancouver, Canada)
- Year and Date
  2010-09-27
- Data Source
  KAKENHI-PROJECT-20590265
[Presentation] キマーゼ阻害薬による腹部大動脈瘤進展予防の可能性(シンポジウム)2010
- Author(s)
  高井真司、金徳男、宮崎瑞夫
- Organizer
  第38回薬物活性シンポジウム
- Place of Presentation
  札幌
- Year and Date
  2010-11-11
- Data Source
  KAKENHI-PROJECT-20590265
[Presentation] キマーゼ阻害薬のターゲット疾患について2010
- Author(s)
  高井真司
- Organizer
  第15回日本病態プロテアーゼ学会
- Place of Presentation
  千里ライフサイエンスセンター(大阪)(招待講演)
- Year and Date
  2010-08-20
- Data Source
  KAKENHI-PROJECT-20590265
[Presentation] キマーゼ阻害薬の開発と臓器保護効果(シンポジウム)2009
- Author(s)
  高井真司、金徳男、宮崎瑞夫
- Organizer
  日本薬理学会
- Place of Presentation
  横浜
- Year and Date
  2009-03-16
- Data Source
  KAKENHI-PROJECT-20590265
[Presentation] キマーゼ阻害薬の開発と臓器保護効果2009
- Author(s)
  高井真司
- Organizer
  第82回日本薬理学会年会(シンポジウム)
- Place of Presentation
  横浜
- Year and Date
  2009-03-16
- Data Source
  KAKENHI-PROJECT-20590265
[Presentation] The role of tryptase and anti-type II collagen antibodies in the pathogenesis of idiopathic epiretinal membranes
- Author(s)
  Tsunehiko Ikeda, Kimitoshi Nakamura, Hidehiro Oku, Seita Morishita, Masanori Fukumoto, Hiroyuki Suzuki, Teruyo Kida, Taeko Horie, Tetsuya Sugiyama, Shinji Takai
- Organizer
  2015　ARVO　Annual Meeting
- Place of Presentation
  Colorado Cnvention Center(Colorado,USA)
- Year and Date
  2015-05-03 – 2015-05-07
- Data Source
  KAKENHI-PROJECT-24592685
[Presentation] 特発性黄斑上膜の病態におけるトリプターゼと2型コラーゲン抗体の関与
- Author(s)
  池田恒彦, 森下清太, 福本雅格, 鈴木浩之, 喜田照代, 奥英弘,中村公俊, 高井真司
- Organizer
  第119回日本眼科学会総会
- Place of Presentation
  ロイトン札幌(北海道札幌市）
- Year and Date
  2015-04-16 – 2015-04-19
- Data Source
  KAKENHI-PROJECT-24592685
[Presentation] マイトマイシン(MMC)包含Gelatin Hydrogelの緑内障濾過手術への応用: MMC単独との比較
- Author(s)
  小嶌祥太、杉山哲也、金　徳男、高井真司、植木麻理、池田恒彦
- Organizer
  第118回日本眼科学会総会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2014-04-02 – 2014-04-06
- Data Source
  KAKENHI-PROJECT-24592684

1. JIN Denan (90319533)

# of Collaborated Projects: 13 results

# of Collaborated Products: 52 results
2. OKU Hidehiro (90177163)

# of Collaborated Projects: 8 results

# of Collaborated Products: 17 results
3. IKEDA Tsunehiko (70222891)

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12. HAYASHI Michihiro (90314179)

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14. HIROKAWA Fumitoshi (20322373)

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17. NEMOTO Shintarou (20237811)

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18. HAMORI Kan (90581207)

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19. FUKUHARA Masayuki (00238510)

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20. OKUNO Takashi (20411366)

# of Collaborated Projects: 2 results

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21. KOMEDA Koji (70531896)

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22. Ohya Yuichi (10213886)

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# of Collaborated Products: 32 results
23. Hosohata Keiko (10547962)

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24. 谷口高平 (70779686)

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25. 柿木佐知朗 (70421419)

# of Collaborated Projects: 2 results

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26. OZAWA Hideki (20277156)

# of Collaborated Projects: 1 results

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27. HOSHIGA Masaaki (90309154)

# of Collaborated Projects: 1 results

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28. SASAKI Tomoyasu (10411365)

# of Collaborated Projects: 1 results

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29. HAYASHI Tetsuya (30257852)

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30. SHIMAZAWA Masamitsu (80381721)

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33. MORI Yasuhiko (20287345)

# of Collaborated Projects: 1 results

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34. OKUMURA Kenichi (10349699)

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35. TATABA Yasuhiko (50211371)

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36. SHIOTA Naotaka (60206050)

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37. 内山和久 (80232867)

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38. 岡本由記子 (10268188)

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39. 葛谷明紀 (00456154)

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40. 宇佐美吉英 (70278589)

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41. 辻川和丈 (10207376)

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42. 岩崎泰彦 (90280990)

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43. 奥野陽太 (60964814)

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44. 上田正人 (40362660)

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45. 橋本朋子 (10589930)

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46. 東野正明 (30397278)

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47. NAKAIZUMI Atsuko

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48. TONARI Masahiro

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49. Kakurai Keigo

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50. 石坂信和

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51. 能崎優太

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52. 衣斐督和

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53. 松本みさき

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# of Collaborated Products: 1 results

Takai Shinji 高井 真司

TAKAI Shinji 高井 真司

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Pathophysiological role of chymase in diabetic complicationsPrincipal Investigator

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Application of a novel nucleic acid agent for chymase-specific inhibitionPrincipal Investigator

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Takai Shinji 高井真司

TAKAI Shinji 高井真司