OHNISHI Hiroaki 大西宏明

… Alternative Names

Researcher Number	80291326
Other IDs
Affiliation (Current)	2022: 杏林大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2015 – 2020: 杏林大学, 医学部, 教授 2011 – 2014: 杏林大学, 医学部, 准教授 2005: 杏林大学, 医学部, 講師 2004: 杏林大, 医学部, 講師 2003: 杏林大学, 医学部, 講師 1998 – 1999: 東京大学, 医学部・附属病院, 助手 1997: 東京大学, 医学部附属病院, 助手
Review Section/Research Field	Principal Investigator Pediatrics / Pediatrics / Laboratory medicine / Basic Section 52010:General internal medicine-related Except Principal Investigator Laboratory medicine / Respiratory surgery / Pediatrics / Applied health science / Basic Section 52010:General internal medicine-related / Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 56040:Obstetrics and gynecology-related
Keywords	Principal Investigator 乳児白血病 / メチル化 / p15 / p16 / MLL / 臍帯血 / Bisulfite法 / JAK2 / スプライシング異常 / 骨髄増殖性腫瘍 … More Except Principal Investigator MLL遺伝子 / CBP遺伝子 / P300遺伝子 / 白血病 / 非結核性抗酸菌 / 全ゲノム解析 / バイオマーカー / microRNA / 次世代シーケンス / 発がんリスク / Germline変異 / 発がん実験 / in vivo発がん実験 / メダカ / ゲノム編集 / ディファレンシアルディスプレイ / サブトラクション / EWS遺伝子 / ABI・1遺伝子 / ディファランシアル・ディスプレイ / ユ-イング肉腫 / t(11;16) / t(11;22) / MLL-CBP / EWS-FLI1 / 遺伝子導入 / ABI-1遺伝子 / AF17q25 / AF5q31 / Nup98遺伝子 / 微生物 / 抗酸菌 / 遺伝子 / 感受性 / 新菌種 / mycobacterium kyorinense / mycobacterium celatum / 薬剤耐性 / rpoB / Mycobacterium kyorinense / 非定型抗酸菌 / 同定不能菌 / 生活習慣病 / 超音波 / 脂肪酸 / 脂肪 / 肝臓 / 脂肪組織 / 脂肪厚 / 脂肪酸組成 / 炎症 / サイトカイン / マイクロRNA / 肺がん / リアルタイムPCR / 非小細胞肺がん / 血中マイクロRNA / circulating microRNA / 血清 / 質量分析 / EGFR V843I germline変異 / 遺伝性肺癌症候群 / 全ゲノムシーケンス / 遺伝子改変マウス / 遺伝子変異導入細胞 / プロテオミクス / 分子シミュレーション / 先制医療 / 肺癌 / 遺伝性肺癌 / 多発癌 / 重複癌 / がん関連遺伝子 / NGSパネル / snRNA / miRNA / コピー数多型 / スプライソソーム / がんゲノム医療 / 生殖細胞系遺伝子変異（Germline変異） / 絨毛膜羊膜炎 / 早産 / バクテリオファージ / 破水 / 細菌性腟症 Less

核内低分子RNA snRNAU2関連断片の機能解明と肺癌予後マーカーとしての評価
- Principal Investigator
  
  相磯聡子
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Kyorin University
Accumulation of comprehensive evidences to promote standardization of phlebotomyPrincipal Investigator
- Principal Investigator
  
  大西宏明
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Kyorin University
発がんリスクと考えられるGermline遺伝子変異によるin vivo発がん実験
- Principal Investigator
  
  大塚弘毅
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Kyorin University
Development of a novel treatment strategy for chorioamnionitis
- Principal Investigator
  
  谷垣伸治
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kyorin University
肺癌の先制医療を可能にするGermline遺伝子変異診断開発の基盤研究
- Principal Investigator
  
  大塚弘毅
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Kyorin University
Construction of dynamic prediction model of EGFR tyrosine kinase inhibitors efficacy for mutated EGFR based on protein three-dimensional structure analysisPrincipal Investigator
- Principal Investigator
  
  Ohnishi Hiroaki
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kyorin University
Development of novel classification of mycobacteria by whole genome analysis and mass spectrometry
- Principal Investigator
  
  Matsushima Satsuki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kyorin University
Clinical and molecular biological study of hereditary lung cancer caused by EGFR germline mutation
- Principal Investigator
  
  Ohtsuka Kouki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Kyorin University
Study of circulating microRNAs as biomarkers of lung cancer
- Principal Investigator
  
  AISO TOSHIKO
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kyorin University
Evaluating the severity and the development of lifestyle-related diseases visually and quantitatively on sonography
- Principal Investigator
  
  Kishino Tomonori
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Kyorin University
Identification of novel non-tuberculous mycobacterium and analysis of the mechanism underlying its resistance to antibiotics
- Principal Investigator
  
  MATSUSHIMA Satsuki
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kyorin University
Genetic analysis of a new syndrome with aberrant JAK2 splicingPrincipal Investigator
- Principal Investigator
  
  OHNISHI Hiroaki
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kyorin University
乳児白血病におけるゲノムのメチル化の異常についての検討Principal Investigator
- Principal Investigator
  
  大西宏明
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kyorin University
白血病の染色体転座に関連する遺伝子の単離とその解析
- Principal Investigator
  
  林泰秀
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
Molecular and epidemiologic analysis of the development of infant leukemiaPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Miyuki, 大西宏明
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The University of Tokyo
ディファレンシアル・ディスプレイ法による転座関連キメラmRNAの役割の解析
- Principal Investigator
  
  HAYASHI Yasuhide
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  The University of Tokyo

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Predisposition to Lung Adenocarcinoma in a Family Harboring the Germline EGFR V843I Mutation2019
- Author(s)
  Ohtsuka K, Ohnishi H, Fujiwara M, Morii T, Matsushima S, Ogura W, Yamasaki S, Kishino T, Tanaka R, Watanabe T
- Journal Title
  
  JCO Precision Oncology
  
  Volume: - Pages: 1-4
- DOI
  10.1200/po.19.00104
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01439, KAKENHI-PROJECT-17K10799
[Journal Article] APC:T1556fs and STK11 mutations in duodenal adenomas and adenocarcinomas.2018
- Author(s)
  Kojima Y, Ohtsuka K, Ohnishi H, Abe N, Furuse J, Watanabe T, Sugiyama M.
- Journal Title
  
  Surg
  
  Volume: 48(8) Pages: 765-772
- DOI
  10.1007/s00595-018-1649-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10799
[Journal Article] Degradation of serum microRNAs during transient storage of serum samples at 4°C2017
- Author(s)
  Toshiko Aiso, Shu Takigami, Akiko Yamaki, Hiroaki Ohnishi
- Journal Title
  
  Annals of Clinical Biochemistry
  
  Volume: 印刷中
- DOI
  10.1177/0004563217704233
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460698
[Journal Article] Relationship between epicardial adipose tissue thickness and early impairment of left ventricular systolic function in patients with preserved ejection fraction．2016
- Author(s)
  Watanabe K，Kishino T，Sano J，Ariga T，Okuyama S，Mori H，Matsushima S，Ohtsuka K，Ohnishi H，Watanabe T
- Journal Title
  
  Heart Vessels
  
  Volume: in press
- DOI
  10.1007/s00380-015-0650-8
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24500866
[Journal Article] Spike-in controlを用いた血中マイクロRNAの測定における検体保存温度および時間についての検討2015
- Author(s)
  相磯聡子、関根名里子、高城靖志、大西宏明
- Journal Title
  
  臨床病理
  
  Volume: 63 Pages: 688-693
- NAID
  40020533641
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460698
[Journal Article] Whole-Genome Sequence of Mycobacterium kyorinense.2014
- Author(s)
  Ohtsuka K, Ohnishi H, Nozaki E, Matsushima S, et al.
- Journal Title
  
  Genome Announc.
  
  Volume: 2
- DOI
  10.1128/genomea.01062-14
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23590688, KAKENHI-PROJECT-24390106, KAKENHI-PROJECT-26460686
[Journal Article] Proposal of reclassification of Mycobacterium celatum type 2 as Mycobacterium kyorinense2014
- Author(s)
  Hiroaki Ohnishi, Enrico Tortoli, Jesus Pais Ramos, Yuko Kazumi, Shota Yonetani, Satsuki Matsushima, Kouki Ohtsuka and Takashi Watanabe
- Journal Title
  
  Ａｎｎａｌｓ　ｏｆ　Ｍｉｃｒｏｂｉｏｌｏｇｙ
  
  Volume: 未定
- DOI
  10.1007/s13213-014-0860-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590688
[Journal Article] Proposal of reclassification of Mycobacterium celatum type 2 as Mycobacterium kyorinense2014
- Author(s)
  Ohnishi H, Tortoli E, Ramos JP, Kazumi Y, Yonetani S, Matsushima S, Ohtsuka K, Watanabe T
- Journal Title
  
  Annals of Microbiology
  
  Volume: 64 Pages: 1879-1882
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590688
[Journal Article] Mycobacterium kyorinense infection2013
- Author(s)
  Ohnishi H, Yonetani S, Matsushima S, Wada H, Takeshita K, Kuramochi D, Caldas PC, Campos CE , Costa BP, Ramos JP, Watanabe T
- Journal Title
  
  Emerging Infectious Diseases
  
  Volume: 19 Pages: 508-510
- DOI
  10.3201/eid1903.120591
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590688
[Journal Article] First isolation of Mycobacterium kyorinense from clinical specimens in Brazil2012
- Author(s)
  Campos CE , Caldas PC, Ohnishi H, Watanabe T, Ohtsuka K, Matsushima S, Ferreira NV, da Silva MV, Redner P, de Carvalho LD, Medeiros RF, Abbud Filho JA , Montes FC, Galvao TC, Ramos JP
- Journal Title
  
  Jounal of Clinical Microbiology
  
  Volume: 50 Pages: 2477-2478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590688
[Presentation] Whole genome sequencing of family members with the germline EGFR V843I mutation predisposed to lung adenocarcinoma.2017
- Author(s)
  Kouki Ohtsuka, Satoko Yamasaki, Satsuki Matsushima, Tomonori Kishino, Hiroaki Ohnishi, Takashi Watanabe
- Organizer
  The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08652
[Presentation] 非小細胞肺癌症例における全ゲノム増幅を用いたEGFR遺伝子変異検査の有用性の検討2017
- Author(s)
  小倉航、大塚弘毅、藤原正親、田中良太、横山琢磨、高木靖志、大西宏明、渡邊卓
- Organizer
  第64回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-15K08652
[Presentation] Mycobacterium Kyorinense infection; Clinical, biological and genetic feature.2017
- Author(s)
  Hiroaki Ohnishi, Kouki Ohtsuka, Yuko Kazumi, Takemasa Takii, Satoshi Mitarai, Satsuki Matsushima, Shota Yoneyama, Satoshi Otani, Takashi Yoshiyama, Yasuhiro Kato, Yata Hayashi, Junishi Machiya, Kaneyuki Kida, Jun Sugihara, Satoko Yamasaki, Tomonori Kishino, Hajime Goto, Takashi Watanabe
- Organizer
  The 29th World congress of world association of societies of pathology and laboratory medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460686
[Presentation] Genetic Mechanism underlying drug resistance in Mycobacterium kyorinense and Mycobacterium celatum2016
- Author(s)
  Hiroaki Ohnishi, Kouki Ohtsuka, Satsuki Matsushima, Eriko Nozaki, Shota Yonetani, Satoko Yamasaki, Tomonori Kishino, Takashi Watanabe
- Organizer
  The 32nd World Congress of Biomedical Laboratory Science
- Place of Presentation
  Kobe, Japan
- Year and Date
  2016-08-31
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460686
[Presentation] 血清マイクロRNAの多様な安定性2016
- Author(s)
  相磯聡子、八巻明子、星野諒太、坂下恵吾、佐藤嘉見、西澤裕太、大西宏明
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-25460698
[Presentation] 喫煙が健常者血中miR-21レベルに及ぼす影響2015
- Author(s)
  相磯聡子、関根名里子、高城靖志、大西宏明、渡邊卓
- Organizer
  臨床検査医学会
- Place of Presentation
  長良川国際会議場
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-25460698
[Presentation] 心エコーで評価した心膜外脂肪厚と心機能障害の関連性について2015
- Author(s)
  藤野あえか，岸野智則，大西宏明，渡邊卓，ほか
- Organizer
  第62回日本臨床検査医学会学術集会
- Place of Presentation
  岐阜
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-24500866
[Presentation] Mycobacterium kyorinenseおよびその近縁種の遺伝子解析2013
- Author(s)
  大西宏明、松島早月、大塚弘毅、米谷正太、荒木光二、岸野智則、渡邊卓
- Organizer
  日本臨床検査医学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590688
[Presentation] 血中脂肪酸組成と主な代謝関連血液生化学検査値との相関性の検討2012
- Author(s)
  岸野智則、大西宏明、渡邊　卓、ほか
- Organizer
  第59回日本臨床検査医学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24500866
[Presentation] JAK2 SPLICING MUTATION IN SIBLINGS PRESENTING WITH MYELOPROLIFERATIVE NEOPLASMS, CARDIOMYOPATHY AND HYPOGONADISM2011
- Author(s)
  Hiroaki Ohnishi, Ken-ichirou Hosoi, Hiroshi Yoshino, Yuki Gemma, Kouki Ohtsuka, Satsuki Matsushima, Fumio Bessho, Takashi Watanabe,　Fujino Takashi
- Organizer
  43th Congress of the International Society of Paediatric Oncology
- Place of Presentation
  Auckland, New Zealand
- Data Source
  KAKENHI-PROJECT-23591550
[Presentation] 遺伝性骨髄増殖性腫瘍の家族例における網羅的遺伝子解析
- Author(s)
  大西宏明, 滝田順子, 松島早月, 大塚弘毅, 岸野智則, 細井健一郎, 大倉康夫, 小川誠司, 渡邊卓
- Organizer
  日本臨床検査医学会
- Place of Presentation
  福岡
- Year and Date
  2014-11-22 – 2014-11-25
- Data Source
  KAKENHI-PROJECT-23591550
[Presentation] Mycobacterium kyorinense 感染症の臨床像の解析
- Author(s)
  大西宏明、松島早月、渡邊卓　他
- Organizer
  第２３回日本臨床微生物学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590688
[Presentation] Mycobacterium kyorinense 感染症の臨床像のスペクトラム
- Author(s)
  大西宏明、松島早月、渡邊卓　他
- Organizer
  第58回日本臨床検査医学会総会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-23590688

1. WATANABE Takashi (00191768)

# of Collaborated Projects: 9 results

# of Collaborated Products: 19 results
2. OHTSUKA Kouki (70439165)

# of Collaborated Projects: 8 results

# of Collaborated Products: 13 results
3. MATSUSHIMA Satsuki (80231596)

# of Collaborated Projects: 7 results

# of Collaborated Products: 12 results
4. KOBAYASHI Miyuki (60205391)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. HAYASHI Yasuhide (30238133)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 別所文雄 (40010285)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. AISO TOSHIKO (40195144)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
8. TAKI Tomohiko (50322053)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 藤原正親 (20407026)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. Kishino Tomonori (20343478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. MORI Hideaki (10239618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. GAMOU SHINOBU (90122308)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. HIGASHI KATSUMI (50159109)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KAWAGUCHI Hiroyuki (00313130)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 横山琢磨 (50439197)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 広川貴次 (20357867)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 中村浩之 (30274434)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 田中良太 (40415063)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. 苣田慎一 (90639791)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 山崎聡子 (90782863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 谷垣伸治 (80286533)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 花輪智子 (80255405)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 松田剛明 (80365204)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 小林陽一 (90205493)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. URATA Tsuyoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. WATANABE Keiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
27. FUJINO Aeka

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
28. 松本壮吉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OHNISHI Hiroaki 大西 宏明

大西 宏明 オオニシ ヒロアキ

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Accumulation of comprehensive evidences to promote standardization of phlebotomyPrincipal Investigator

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Construction of dynamic prediction model of EGFR tyrosine kinase inhibitors efficacy for mutated EGFR based on protein three-dimensional structure analysisPrincipal Investigator

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Genetic analysis of a new syndrome with aberrant JAK2 splicingPrincipal Investigator

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乳児白血病におけるゲノムのメチル化の異常についての検討Principal Investigator

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Molecular and epidemiologic analysis of the development of infant leukemiaPrincipal Investigator

Principal Investigator

OHNISHI Hiroaki 大西宏明

大西宏明オオニシヒロアキ