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OHNISHI Hiroaki  大西 宏明

ORCIDConnect your ORCID iD *help
… Alternative Names

大西 宏明  オオニシ ヒロアキ

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Researcher Number 80291326
Other IDs
Affiliation (Current) 2022: 杏林大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2015 – 2020: 杏林大学, 医学部, 教授
2011 – 2014: 杏林大学, 医学部, 准教授
2005: 杏林大学, 医学部, 講師
2004: 杏林大, 医学部, 講師
2003: 杏林大学, 医学部, 講師
1998 – 1999: 東京大学, 医学部・附属病院, 助手
1997: 東京大学, 医学部附属病院, 助手
Review Section/Research Field
Principal Investigator
Pediatrics / Pediatrics / Laboratory medicine / Basic Section 52010:General internal medicine-related
Except Principal Investigator
Laboratory medicine / Respiratory surgery / Pediatrics / Applied health science / Basic Section 52010:General internal medicine-related / Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 56040:Obstetrics and gynecology-related
Keywords
Principal Investigator
乳児白血病 / メチル化 / p15 / p16 / MLL / 臍帯血 / Bisulfite法 / JAK2 / スプライシング異常 / 骨髄増殖性腫瘍 … More / GATA1 / スプライシング / 先天性骨髄増殖性腫瘍 / DGKK / JAK2 / 先天異常 / 11q23転座 / MLL遺伝子 / ABI-1遺伝子 / AF4q31遺伝子 / SEPTIN6遺伝子 / LF4遺伝子 / AF4遺伝子 / AF5q31遺伝子 / t(4 ; 11) / gene chip / LAF4遺伝子 / FMR2遺伝子 / t(4;11) / infant leukemia / 11q23 translocation / MLL gene / ABI-1 gene / AF4q31 gene / SEPTIN6 gene / AF4 gene / EGFR / チロシンキナーゼ阻害剤 / 肺癌 / 動的分子シミュレーション / 動的立体構造解析 / チロシンキナーゼ阻害薬 / 分子動力学モデル / 分子動態モデリング / 採血 / 検体保存 / 標準採血法 / 神経損傷 / 皮膚消毒 / プレアナリティカル … More
Except Principal Investigator
MLL遺伝子 / CBP遺伝子 / P300遺伝子 / 白血病 / 非結核性抗酸菌 / 全ゲノム解析 / バイオマーカー / microRNA / 次世代シーケンス / 発がんリスク / Germline変異 / 発がん実験 / in vivo発がん実験 / メダカ / ゲノム編集 / ディファレンシアルディスプレイ / サブトラクション / EWS遺伝子 / ABI・1遺伝子 / ディファランシアル・ディスプレイ / ユ-イング肉腫 / t(11;16) / t(11;22) / MLL-CBP / EWS-FLI1 / 遺伝子導入 / ABI-1遺伝子 / AF17q25 / AF5q31 / Nup98遺伝子 / 微生物 / 抗酸菌 / 遺伝子 / 感受性 / 新菌種 / mycobacterium kyorinense / mycobacterium celatum / 薬剤耐性 / rpoB / Mycobacterium kyorinense / 非定型抗酸菌 / 同定不能菌 / 生活習慣病 / 超音波 / 脂肪酸 / 脂肪 / 肝臓 / 脂肪組織 / 脂肪厚 / 脂肪酸組成 / 炎症 / サイトカイン / マイクロRNA / 肺がん / リアルタイムPCR / 非小細胞肺がん / 血中マイクロRNA / circulating microRNA / 血清 / 質量分析 / EGFR V843I germline変異 / 遺伝性肺癌症候群 / 全ゲノムシーケンス / 遺伝子改変マウス / 遺伝子変異導入細胞 / プロテオミクス / 分子シミュレーション / 先制医療 / 肺癌 / 遺伝性肺癌 / 多発癌 / 重複癌 / がん関連遺伝子 / NGSパネル / snRNA / miRNA / コピー数多型 / スプライソソーム / がんゲノム医療 / 生殖細胞系遺伝子変異(Germline変異) / 絨毛膜羊膜炎 / 早産 / バクテリオファージ / 破水 / 細菌性腟症 Less
  • Research Projects

    (16 results)
  • Research Products

    (23 results)
  • Co-Researchers

    (28 People)
  •  核内低分子RNA snRNAU2関連断片の機能解明と肺癌予後マーカーとしての評価

    • Principal Investigator
      相磯 聡子
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      Kyorin University
  •  Accumulation of comprehensive evidences to promote standardization of phlebotomyPrincipal Investigator

    • Principal Investigator
      大西 宏明
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      Kyorin University
  •  発がんリスクと考えられるGermline遺伝子変異によるin vivo発がん実験

    • Principal Investigator
      大塚 弘毅
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Kyorin University
  •  Development of a novel treatment strategy for chorioamnionitis

    • Principal Investigator
      谷垣 伸治
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Kyorin University
  •  肺癌の先制医療を可能にするGermline遺伝子変異診断開発の基盤研究

    • Principal Investigator
      大塚 弘毅
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory surgery
    • Research Institution
      Kyorin University
  •  Construction of dynamic prediction model of EGFR tyrosine kinase inhibitors efficacy for mutated EGFR based on protein three-dimensional structure analysisPrincipal Investigator

    • Principal Investigator
      Ohnishi Hiroaki
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Kyorin University
  •  Development of novel classification of mycobacteria by whole genome analysis and mass spectrometry

    • Principal Investigator
      Matsushima Satsuki
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Kyorin University
  •  Clinical and molecular biological study of hereditary lung cancer caused by EGFR germline mutation

    • Principal Investigator
      Ohtsuka Kouki
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory surgery
    • Research Institution
      Kyorin University
  •  Study of circulating microRNAs as biomarkers of lung cancer

    • Principal Investigator
      AISO TOSHIKO
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Kyorin University
  •  Evaluating the severity and the development of lifestyle-related diseases visually and quantitatively on sonography

    • Principal Investigator
      Kishino Tomonori
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied health science
    • Research Institution
      Kyorin University
  •  Identification of novel non-tuberculous mycobacterium and analysis of the mechanism underlying its resistance to antibiotics

    • Principal Investigator
      MATSUSHIMA Satsuki
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Kyorin University
  •  Genetic analysis of a new syndrome with aberrant JAK2 splicingPrincipal Investigator

    • Principal Investigator
      OHNISHI Hiroaki
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Kyorin University
  •  乳児白血病におけるゲノムのメチル化の異常についての検討Principal Investigator

    • Principal Investigator
      大西 宏明
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pediatrics
    • Research Institution
      Kyorin University
  •  白血病の染色体転座に関連する遺伝子の単離とその解析

    • Principal Investigator
      林 泰秀
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The University of Tokyo
  •  Molecular and epidemiologic analysis of the development of infant leukemiaPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Miyuki, 大西 宏明
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The University of Tokyo
  •  ディファレンシアル・ディスプレイ法による転座関連キメラmRNAの役割の解析

    • Principal Investigator
      HAYASHI Yasuhide
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pediatrics
    • Research Institution
      The University of Tokyo

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

  • [Journal Article] Predisposition to Lung Adenocarcinoma in a Family Harboring the Germline EGFR V843I Mutation2019

    • Author(s)
      Ohtsuka K, Ohnishi H, Fujiwara M, Morii T, Matsushima S, Ogura W, Yamasaki S, Kishino T, Tanaka R, Watanabe T
    • Journal Title

      JCO Precision Oncology

      Volume: - Pages: 1-4

    • DOI

      10.1200/po.19.00104

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K01439, KAKENHI-PROJECT-17K10799
  • [Journal Article] APC:T1556fs and STK11 mutations in duodenal adenomas and adenocarcinomas.2018

    • Author(s)
      Kojima Y, Ohtsuka K, Ohnishi H, Abe N, Furuse J, Watanabe T, Sugiyama M.
    • Journal Title

      Surg

      Volume: 48(8) Pages: 765-772

    • DOI

      10.1007/s00595-018-1649-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10799
  • [Journal Article] Degradation of serum microRNAs during transient storage of serum samples at 4°C2017

    • Author(s)
      Toshiko Aiso, Shu Takigami, Akiko Yamaki, Hiroaki Ohnishi
    • Journal Title

      Annals of Clinical Biochemistry

      Volume: 印刷中

    • DOI

      10.1177/0004563217704233

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25460698
  • [Journal Article] Relationship between epicardial adipose tissue thickness and early impairment of left ventricular systolic function in patients with preserved ejection fraction.2016

    • Author(s)
      Watanabe K,Kishino T,Sano J,Ariga T,Okuyama S,Mori H,Matsushima S,Ohtsuka K,Ohnishi H,Watanabe T
    • Journal Title

      Heart Vessels

      Volume: in press

    • DOI

      10.1007/s00380-015-0650-8

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24500866
  • [Journal Article] Spike-in controlを用いた血中マイクロRNAの測定における検体保存温度および時間についての検討2015

    • Author(s)
      相磯聡子、関根名里子、高城靖志、大西宏明
    • Journal Title

      臨床病理

      Volume: 63 Pages: 688-693

    • NAID

      40020533641

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25460698
  • [Journal Article] Whole-Genome Sequence of Mycobacterium kyorinense.2014

    • Author(s)
      Ohtsuka K, Ohnishi H, Nozaki E, Matsushima S, et al.
    • Journal Title

      Genome Announc.

      Volume: 2

    • DOI

      10.1128/genomea.01062-14

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23590688, KAKENHI-PROJECT-24390106, KAKENHI-PROJECT-26460686
  • [Journal Article] Proposal of reclassification of Mycobacterium celatum type 2 as Mycobacterium kyorinense2014

    • Author(s)
      Hiroaki Ohnishi, Enrico Tortoli, Jesus Pais Ramos, Yuko Kazumi, Shota Yonetani, Satsuki Matsushima, Kouki Ohtsuka and Takashi Watanabe
    • Journal Title

      Annals of Microbiology

      Volume: 未定

    • DOI

      10.1007/s13213-014-0860-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590688
  • [Journal Article] Proposal of reclassification of Mycobacterium celatum type 2 as Mycobacterium kyorinense2014

    • Author(s)
      Ohnishi H, Tortoli E, Ramos JP, Kazumi Y, Yonetani S, Matsushima S, Ohtsuka K, Watanabe T
    • Journal Title

      Annals of Microbiology

      Volume: 64 Pages: 1879-1882

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590688
  • [Journal Article] Mycobacterium kyorinense infection2013

    • Author(s)
      Ohnishi H, Yonetani S, Matsushima S, Wada H, Takeshita K, Kuramochi D, Caldas PC, Campos CE , Costa BP, Ramos JP, Watanabe T
    • Journal Title

      Emerging Infectious Diseases

      Volume: 19 Pages: 508-510

    • DOI

      10.3201/eid1903.120591

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590688
  • [Journal Article] First isolation of Mycobacterium kyorinense from clinical specimens in Brazil2012

    • Author(s)
      Campos CE , Caldas PC, Ohnishi H, Watanabe T, Ohtsuka K, Matsushima S, Ferreira NV, da Silva MV, Redner P, de Carvalho LD, Medeiros RF, Abbud Filho JA , Montes FC, Galvao TC, Ramos JP
    • Journal Title

      Jounal of Clinical Microbiology

      Volume: 50 Pages: 2477-2478

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590688
  • [Presentation] Whole genome sequencing of family members with the germline EGFR V843I mutation predisposed to lung adenocarcinoma.2017

    • Author(s)
      Kouki Ohtsuka, Satoko Yamasaki, Satsuki Matsushima, Tomonori Kishino, Hiroaki Ohnishi, Takashi Watanabe
    • Organizer
      The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08652
  • [Presentation] 非小細胞肺癌症例における全ゲノム増幅を用いたEGFR遺伝子変異検査の有用性の検討2017

    • Author(s)
      小倉航、大塚弘毅、藤原正親、田中良太、横山琢磨、高木靖志、大西宏明、渡邊卓
    • Organizer
      第64回日本臨床検査医学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K08652
  • [Presentation] Mycobacterium Kyorinense infection; Clinical, biological and genetic feature.2017

    • Author(s)
      Hiroaki Ohnishi, Kouki Ohtsuka, Yuko Kazumi, Takemasa Takii, Satoshi Mitarai, Satsuki Matsushima, Shota Yoneyama, Satoshi Otani, Takashi Yoshiyama, Yasuhiro Kato, Yata Hayashi, Junishi Machiya, Kaneyuki Kida, Jun Sugihara, Satoko Yamasaki, Tomonori Kishino, Hajime Goto, Takashi Watanabe
    • Organizer
      The 29th World congress of world association of societies of pathology and laboratory medicine
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460686
  • [Presentation] Genetic Mechanism underlying drug resistance in Mycobacterium kyorinense and Mycobacterium celatum2016

    • Author(s)
      Hiroaki Ohnishi, Kouki Ohtsuka, Satsuki Matsushima, Eriko Nozaki, Shota Yonetani, Satoko Yamasaki, Tomonori Kishino, Takashi Watanabe
    • Organizer
      The 32nd World Congress of Biomedical Laboratory Science
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2016-08-31
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460686
  • [Presentation] 血清マイクロRNAの多様な安定性2016

    • Author(s)
      相磯聡子、八巻明子、星野諒太、坂下恵吾、佐藤嘉見、西澤裕太、大西宏明
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-25460698
  • [Presentation] 喫煙が健常者血中miR-21レベルに及ぼす影響2015

    • Author(s)
      相磯聡子、関根名里子、高城靖志、大西宏明、渡邊卓
    • Organizer
      臨床検査医学会
    • Place of Presentation
      長良川国際会議場
    • Year and Date
      2015-11-19
    • Data Source
      KAKENHI-PROJECT-25460698
  • [Presentation] 心エコーで評価した心膜外脂肪厚と心機能障害の関連性について2015

    • Author(s)
      藤野あえか,岸野智則,大西宏明,渡邊 卓,ほか
    • Organizer
      第62回日本臨床検査医学会学術集会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-11-19
    • Data Source
      KAKENHI-PROJECT-24500866
  • [Presentation] Mycobacterium kyorinenseおよびその近縁種の遺伝子解析2013

    • Author(s)
      大西宏明、松島早月、大塚弘毅、米谷正太、荒木光二、岸野智則、渡邊卓
    • Organizer
      日本臨床検査医学会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23590688
  • [Presentation] 血中脂肪酸組成と主な代謝関連血液生化学検査値との相関性の検討2012

    • Author(s)
      岸野智則、大西宏明、渡邊 卓、ほか
    • Organizer
      第59回日本臨床検査医学会学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-24500866
  • [Presentation] JAK2 SPLICING MUTATION IN SIBLINGS PRESENTING WITH MYELOPROLIFERATIVE NEOPLASMS, CARDIOMYOPATHY AND HYPOGONADISM2011

    • Author(s)
      Hiroaki Ohnishi, Ken-ichirou Hosoi, Hiroshi Yoshino, Yuki Gemma, Kouki Ohtsuka, Satsuki Matsushima, Fumio Bessho, Takashi Watanabe, Fujino Takashi
    • Organizer
      43th Congress of the International Society of Paediatric Oncology
    • Place of Presentation
      Auckland, New Zealand
    • Data Source
      KAKENHI-PROJECT-23591550
  • [Presentation] 遺伝性骨髄増殖性腫瘍の家族例における網羅的遺伝子解析

    • Author(s)
      大西 宏明, 滝田 順子, 松島 早月, 大塚 弘毅, 岸野 智則, 細井 健一郎, 大倉 康夫, 小川 誠司, 渡邊 卓
    • Organizer
      日本臨床検査医学会
    • Place of Presentation
      福岡
    • Year and Date
      2014-11-22 – 2014-11-25
    • Data Source
      KAKENHI-PROJECT-23591550
  • [Presentation] Mycobacterium kyorinense 感染症の臨床像の解析

    • Author(s)
      大西宏明、松島早月、渡邊卓 他
    • Organizer
      第23回日本臨床微生物学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23590688
  • [Presentation] Mycobacterium kyorinense 感染症の臨床像のスペクトラム

    • Author(s)
      大西宏明、松島早月、渡邊卓 他
    • Organizer
      第58回日本臨床検査医学会総会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-23590688
  • 1.  WATANABE Takashi (00191768)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 19 results
  • 2.  OHTSUKA Kouki (70439165)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 13 results
  • 3.  MATSUSHIMA Satsuki (80231596)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 12 results
  • 4.  KOBAYASHI Miyuki (60205391)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  HAYASHI Yasuhide (30238133)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  別所 文雄 (40010285)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  AISO TOSHIKO (40195144)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 8.  TAKI Tomohiko (50322053)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  藤原 正親 (20407026)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 10.  Kishino Tomonori (20343478)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 11.  MORI Hideaki (10239618)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 12.  GAMOU SHINOBU (90122308)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  HIGASHI KATSUMI (50159109)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  KAWAGUCHI Hiroyuki (00313130)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  横山 琢磨 (50439197)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  広川 貴次 (20357867)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  中村 浩之 (30274434)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  田中 良太 (40415063)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 19.  苣田 慎一 (90639791)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  山崎 聡子 (90782863)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  谷垣 伸治 (80286533)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  花輪 智子 (80255405)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  松田 剛明 (80365204)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  小林 陽一 (90205493)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  URATA Tsuyoshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  WATANABE Keiko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 27.  FUJINO Aeka
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 28.  松本 壮吉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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